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1. Kravarusic D, Feigin E, Dlugy E, Steinberg R, Baazov A, Erez I, Lazar L, Kapuller V, Grunspan M, Ash S, Freud E: Colorectal carcinoma in childhood: a retrospective multicenter study. J Pediatr Gastroenterol Nutr; 2007 Feb;44(2):209-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this multicenter study was to document the clinical profile, treatment and prognosis of colorectal carcinoma in children in Israel.
  • PATIENTS AND METHODS: The clinical, laboratory, therapeutic, and prognostic parameters of all 7 children from 4 medical centers in Israel who were diagnosed with colorectal carcinoma over a 25-y period were reviewed.
  • RESULTS: Patients presented with rectal bleeding (4 of 7), abdominal pain (2 of 7), and abdominal distension (2 of 7).
  • Average time to diagnosis was 6 months.
  • Six patients underwent surgery (1 refused), and 5 received chemotherapy.
  • Histopathological studies showed poorly differentiated mucinous adenocarcinoma, signet-ring type, in 4 cases, moderately differentiated adenocarcinoma in 2, and well-differentiated carcinoma in 1.
  • Heightened physician awareness of the possibility of this disease in children, with special attention to adolescents with predisposing factors and rectal bleeding, could help to improve outcome.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Child, Preschool. Colectomy. Female. Humans. Israel. Male. Prognosis. Retrospective Studies

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  • (PMID = 17255833.001).
  • [ISSN] 1536-4801
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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2. Nishimura R, Teramoto N, Tanada M, Kurita A, Mogami H: Inflammatory pseudotumor of the liver associated with malignant disease: report of two cases and a review of the literature. Virchows Arch; 2005 Sep;447(3):660-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The first patient was a 63-year-old woman who underwent distal gastrectomy and partial hepatectomy under a diagnosis of stomach cancer with liver metastasis.
  • The second patient was a 66-year-old man who had undergone surgery for rectal cancer 6 years previously and underwent partial hepatectomy under a diagnosis of metastasis of rectal cancer to the liver.
  • The gastric cancer was a papillary adenocarcinoma limited to the mucosa, and the rectal cancer was a moderately differentiated adenocarcinoma limited to the subserosa.
  • The cut surface showed that both masses were well circumscribed and divided into lobules by fibrous tissue.
  • Obliterating phlebitis suggesting infection via the portal vein was seen in the adjacent liver tissue in both cases.
  • According to previous cases reported in the literature, there are three types of cancers associated with hepatic IPT: gastrointestinal tract cancer, biliary tract cancer, and cancers that need strong systemic chemotherapy.
  • The underlying cancer types of IPT of the liver are almost similar to those associated with pyogenic liver abscesses suggesting the etiological correlation between IPT and abscesses of the liver.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / pathology. Granuloma, Plasma Cell / complications. Granuloma, Plasma Cell / pathology. Liver Diseases / pathology
  • [MeSH-minor] Aged. Female. Humans. Immunohistochemistry. Liver Abscess / complications. Liver Abscess / pathology. Male. Middle Aged. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 15968548.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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3. Neagoe A, Chira O, Zaharia T, Cruciat C: Education and management of patients with familial adenomatous polyposis. Are we making progress? A case report. Rom J Gastroenterol; 2004 Dec;13(4):333-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 25-year-old male patient was admitted to our clinic for abdominal pain, diarrhea, intermittent rectal bleeding and weight loss.
  • Histopathological diagnosis revealed moderately differentiated adenocarcinoma.
  • Adjuvant chemotherapy was carried out.
  • Two of them were diagnosed with adenomatous polyposis - the first with classic FAP and the other one with the attenuated type (AFAP).
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyposis Coli. Colorectal Neoplasms / pathology. Patient Education as Topic


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4. Osawa T, Shirasaki S, Tamamura H, Hinoshita T: [A case successfully treated with multidisciplinary treatment against recurrence of lateral lymph node and liver for rectal cancer]. Gan To Kagaku Ryoho; 2010 Jul;37(7):1393-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case successfully treated with multidisciplinary treatment against recurrence of lateral lymph node and liver for rectal cancer].
  • We report a case successfully treated with multidisciplinary treatment against recurrence of lateral lymph node and liver for rectal cancer.
  • The patient was a 61-year-old man with lower rectal cancer (moderately-differentiated tubular adenocarcinoma).
  • Final findings were pA, pN1, sH0, sP0, cM0, fStage IIIa, and S-1 was given as postoperative adjuvant chemotherapy.
  • Chemotherapy with FOLFOX4 was performed.
  • However, because of elevated CEA, concurrent chemoradiotherapy with FOLFOX4 and radiation (60 Gy) was performed.
  • Though CEA decreased once after chemoradiotherapy, it rose again in chemotherapy with FOLFOX4.
  • The chemotherapy regimen was changed to FOLFIRI.
  • Thereafter, chemotherapy with CPT-11 was continuously performed.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Liver Neoplasms / drug therapy. Rectal Neoplasms / drug therapy
  • [MeSH-minor] Humans. Lymphatic Metastasis / radiography. Lymphatic Metastasis / radionuclide imaging. Male. Middle Aged. Positron-Emission Tomography. Recurrence. Tomography, X-Ray Computed


5. Kömürcü S, Ozet A, Oztürk B, Arpaci F, Altundağ MK, Tezcan Y: Colon cancer during pregnancy. A case report. J Reprod Med; 2001 Jan;46(1):75-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CASE: A 33-year-old woman, gravida 2, para 1, was admitted at 30 weeks' gestational age with a history of rectal bleeding and right upper quadrant pain.
  • Histologic examination confirmed serosal and lymph node invasion of moderately differentiated mucous-secreting adenocarcinoma of the cecum and adenocarcinoma metastatic to the liver.
  • The patient received systemic chemotherapy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colonic Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Cesarean Section. Embolization, Therapeutic. Fatal Outcome. Female. Gestational Age. Hepatic Artery. Humans. Liver Neoplasms / secondary. Pregnancy. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 11209639.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Añibarro Laca E, Pérez-Irezabal Pindado JC, Ibáñez Calle T, Llarena Ibarguren R: [Metastases from a rectal adenocarcinoma to the prepuce]. Arch Esp Urol; 2006 Sep;59(7):737-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastases from a rectal adenocarcinoma to the prepuce].
  • [Transliterated title] Metastasis subcutáneas en prepucio secundarias a adenocarcinoma de recto.
  • OBJECTIVE: We report one case of metastatic dissemination of a rectal adenocarcinoma to the prepuce.
  • METHODS: 61-year-old patient with the diagnosis of rectal adenocarcinoma treated 18 months before by surgery and chemotherapy.
  • RESULTS: The pathologic study reported a moderately differentiated intestinal type adenocarcinoma with high mitotic index infiltrating the squamous cell flat epithelium of the prepuce.
  • Surgical excision confirms the origin and may avoid bleeding and discomfort, and also may help with catheterization, which is many times necessary in the final stages.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Rectal Neoplasms / pathology

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  • [CommentIn] Arch Esp Urol. 2006 Nov;59(9):926; author reply 927 [17190224.001]
  • (PMID = 17078400.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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7. Takeda Y, Hasuike Y, Mishima H, Nishisho I, Kikkawa N: [Case report--efficacy of short-term intraarterial 5-fluorouracil for liver metastasis from colorectal cancer]. Gan To Kagaku Ryoho; 2000 Oct;27(12):1838-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 57-year-old woman with a solitary liver metastasis from rectal cancer was treated by continuous HAI of 5-FU (1,000 mg/day) for 6 days.
  • Computed tomography revealed a decrease of 55.6% in the size of the liver tumor.
  • Histological examination of the resected tumor showed marked degeneration, necrosis, fibrosis, and calcification with viable moderately differentiated adenocarcinoma cells.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antimetabolites, Antineoplastic / administration & dosage. Colorectal Neoplasms / pathology. Fluorouracil / administration & dosage. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary
  • [MeSH-minor] Combined Modality Therapy. Drug Administration Schedule. Female. Humans. Infusions, Intra-Arterial. Middle Aged

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  • (PMID = 11086425.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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8. Sugimoto S, Noura S, Seki Y, Ohue M, Motoori M, Goto K, Kishi K, Eguchi H, Yamada T, Miyashiro I, Ohigashi H, Yano M, Ishikawa O, Tanaka E, Nishiyama K: [A case of metastatic liver cancer from rectal cancer demonstrating a clinical CR with 3D-CRT]. Gan To Kagaku Ryoho; 2008 Nov;35(12):2171-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of metastatic liver cancer from rectal cancer demonstrating a clinical CR with 3D-CRT].
  • The patient was a 62-year-old man who underwent a low anterior resection for rectal cancer.
  • The tumor was a moderately differentiated adenocarcinoma, type 2 in the Japanese classification of colorectal carcinoma.
  • He did not receive any adjuvant chemotherapy.
  • We diagnosed liver metastasis of the rectal cancer.
  • The patient refused a surgery and chemotherapy.
  • He was given a total dose of 60 Gy/10 fractions/10 days with 3D-CRT.
  • At 19 months from the radio therapy, the disease was diagnosed as CR because no tumors were detected.
  • 3D-CRT appears to be effective for liver metastasis from the rectal cancer.
  • [MeSH-major] Liver Neoplasms / radiotherapy. Liver Neoplasms / secondary. Rectal Neoplasms / pathology. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Carcinoembryonic Antigen / blood. Humans. Imaging, Three-Dimensional. Male. Middle Aged. Remission Induction. Tomography, X-Ray Computed


9. Matsushita D, Kitazono M, Baba K, Ishigami S, Shinchi H, Ueno S, Ogawa H, Natsugoe S: [A case of advanced rectal cancer with liver and lung metastasis showing a complete response by neo-adjuvant FOLFOX4 chemotherapy]. Gan To Kagaku Ryoho; 2010 Jan;37(1):173-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of advanced rectal cancer with liver and lung metastasis showing a complete response by neo-adjuvant FOLFOX4 chemotherapy].
  • Colonoscopy detected rectal cancer and sigmoid al polyps.
  • The biopsy results suggested that the rectal lesion was well- to moderately-differentiated adenocarcinoma and the sigmoidal polyp contained well -differentiated adenocarcinoma.
  • We judged the case to be inoperable and decided to start systemic chemotherapy (FOLFOX4).
  • After treatment with chemotherapy, the tumor shrank and metastatic lesions disappeared.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Rectal Neoplasms / drug therapy
  • [MeSH-minor] Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Male. Middle Aged. Neoadjuvant Therapy

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  • (PMID = 20087057.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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10. Kumazawa S, Murata Y, Ishita T, Nakamura S, Tamura N, Oikawa Y, Kubo Y, Kurata N, Yagi K, Hattori S, Bando M, Mori M, Matsumoto K, Sato Y, Machinami R: [A case of advanced rectal cancer with multiple liver metastases successfully treated by perioperative administration of UFT and oral leucovorin]. Gan To Kagaku Ryoho; 2010 Sep;37(9):1817-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of advanced rectal cancer with multiple liver metastases successfully treated by perioperative administration of UFT and oral leucovorin].
  • The patient was a sixty-five-year-old man who had an advanced rectal cancer (Ra, type 2) with liver metastases.
  • The pathological finding was moderately-differentiated adenocarcinoma.
  • He was treated with 5-FU via the hepatic artery, but the therapy failed due to catheter infection after 3 postoperative months.
  • Then, he received general 5-FU/l-LV therapy intravenously from 3 to 8 months after the operation, and oral UFT/LV (Uzel®) from 9 to 22 months.
  • Next, we switched to single UFT therapy at 23 months because CT findings showed remarkable calcification in the liver metastases.
  • We switched the chemotherapy again to UFT/Uzel and mFOLFOX6, but decided to perform hepatectomy of S6/7 at 39 months since it proved ineffective.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Leucovorin / therapeutic use. Liver Neoplasms / drug therapy. Rectal Neoplasms / drug therapy
  • [MeSH-minor] Administration, Oral. Aged. Combined Modality Therapy. Hepatectomy. Humans. Male. Neoplasm Staging. Tegafur / administration & dosage. Tegafur / therapeutic use. Tomography, X-Ray Computed. Uracil / administration & dosage. Uracil / therapeutic use

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  • (PMID = 20841955.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q573I9DVLP / Leucovorin; 1-UFT protocol
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11. Takahashi T, Itoh Y: [Effect on neoadjuvant chemotherapy using s-1 for unresectable liver metastasis from rectal cancer-a case report]. Gan To Kagaku Ryoho; 2009 Dec;36(13):2669-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effect on neoadjuvant chemotherapy using s-1 for unresectable liver metastasis from rectal cancer-a case report].
  • The patient was a 42-year-old female who had advanced rectal cancer(Ra, type 2)with liver metastasis.
  • She underwent low anterior resection for primary rectal cancer at first after she was given S-1 80 mg/day(14 days)for a histological effect judgment.
  • The pathological diagnosis was moderately-differentiated adenocarcinoma, ss, n1, and the histological effect was Grade 1a.
  • Because CT showed reduction of liver metastasis after the operation, she was treated with 2 courses of chemotherapy using S-1.
  • In January, 2005, she underwent hepatectomy and the pathological diagnosis was moderately-differentiated adenocarcinoma, metastasis and the histological effect was Grade 1a.
  • We experienced this case in which preoperative S-1 proved effective for liver metastasis from rectal cancer.
  • [MeSH-major] Adenocarcinoma / pathology. Antimetabolites, Antineoplastic / therapeutic use. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Oxonic Acid / therapeutic use. Rectal Neoplasms / pathology. Tegafur / therapeutic use
  • [MeSH-minor] Adult. Drug Combinations. Female. Hepatectomy. Humans. Neoadjuvant Therapy

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  • (PMID = 20009478.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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12. Colonias A, Farinash L, Miller L, Jones S, Medich DS, Greenberg L, Miller R, Parda DS: Multidisciplinary treatment of synchronous primary rectal and prostate cancers. Nat Clin Pract Oncol; 2005 May;2(5):271-4; quiz 1 p following 274
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multidisciplinary treatment of synchronous primary rectal and prostate cancers.
  • BACKGROUND: A 58-year-old Caucasian man with a history of irritable bowel syndrome and occasional rectal bleeding presented with a 4-week history of progressive, bright red blood per rectum.
  • A digital rectal examination revealed a 3 cm distal, midrectal mass.
  • INVESTIGATIONS: Digital rectal examination, colonoscopy, rectal mass biopsy, endorectal ultrasound, transrectal ultrasound-guided prostate biopsy, CT scan and MRI.
  • DIAGNOSIS: Clinical stage III (T3N1M0), moderately differentiated adenocarcinoma of the rectum and clinical stage II (T1cN0M0) adenocarcinoma of the prostate.
  • MANAGEMENT: Intensity-modulated radiation therapy, chemoradiation, chemotherapy, hormone therapy and surgery.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasms, Multiple Primary / pathology. Prostatic Neoplasms / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents, Hormonal / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Gastrointestinal Hemorrhage / etiology. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 16264963.001).
  • [ISSN] 1743-4254
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal
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13. Katsumata K, Ichimiya H, Wakana Y, Okada K, Kato K, Aoki T: [Case report of two colorectal cancer patients with liver metastasis showing favorable response to fluorouracil and l-leucovorin therapy]. Gan To Kagaku Ryoho; 2004 Apr;31(4):623-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case report of two colorectal cancer patients with liver metastasis showing favorable response to fluorouracil and l-leucovorin therapy].
  • We treated 2 patients with colorectal cancer accompanied by liver metastasis who showed favorable response to combined treatment with fluorouracil and l-Leucovorin.
  • Case 1 was a 40-year-old man with rectal carcinoma (moderately differentiated adenocarcinoma; se, n1, p1, H0, stage IV).
  • As of 30 months post-treatment the patient was alive.
  • Case 2 was a 60-year-old man with rectal carcinoma (well differentiated adenocarcinoma; ss, n1, p0, H1, stage IV).
  • Adverse drug reactions in both patients were controlled on an outpatient basis.
  • While in the past liver metastasis has been treated by hepatic arterial infusion chemotherapy, a combination therapy with fluorouracil and l-Leucovorin can be used on an outpatient basis and results in a favorable response.
  • This suggests that this combination therapy has clinical significance.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Rectal Neoplasms / drug therapy
  • [MeSH-minor] Adult. Drug Administration Schedule. Fluorouracil / administration & dosage. Hepatic Artery. Humans. Infusions, Intra-Arterial. Leucovorin / administration & dosage. Male. Middle Aged. Peritoneal Neoplasms / secondary

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  • (PMID = 15114713.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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14. Kanoh T, Ohnishi T, Danno K, Watanabe A, Nakamura H, Tsukao Y, Inatome J, Kim C, Kagara N, Taniguchi H, Kimura Y, Tono T, Nakano Y, Monden T, Imaoka S: [A case of successfully treated lower rectal cancer with both inguinal lymph nodes by chemoradiotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2611-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of successfully treated lower rectal cancer with both inguinal lymph nodes by chemoradiotherapy].
  • We report a case of successfully treated lower rectal cancer with both inguinal lymph nodes by chemoradiotherapy.
  • A colonoscopy revealed primary rectal cancer.
  • The histological diagnosis was well to moderately differentiated adenocarcinoma.
  • A computed tomography showed metastases to pararectal, both inguinal lymph nodes and right external iliac.
  • After a ileostomy construction was done, he was treated with intensity modulated radiotherapy (a total 50.4 Gy) and chemotherapy with FOLFOX.
  • Nine months after radiation therapy, however, multiple lung and liver metastases were observed by a computed tomography, which were treated by systemic chemotherapy with FOLFOX and bevacizumab.
  • [MeSH-major] Adenocarcinoma / therapy. Lymphatic Metastasis. Rectal Neoplasms / therapy
  • [MeSH-minor] Angiogenesis Inhibitors / administration & dosage. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bevacizumab. Combined Modality Therapy. Fluorouracil / therapeutic use. Humans. Ileostomy. Inguinal Canal. Leucovorin / therapeutic use. Male. Middle Aged. Organoplatinum Compounds / therapeutic use. Radiotherapy, Intensity-Modulated

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  • (PMID = 21224655.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 2S9ZZM9Q9V / Bevacizumab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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15. Blair S, Ellenhorn JD: Transanal excision for low rectal cancers is curative in early-stage disease with favorable histology. Am Surg; 2000 Sep;66(9):817-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transanal excision for low rectal cancers is curative in early-stage disease with favorable histology.
  • Controversy still exists as to the optimal treatment of early-stage low rectal cancers.
  • We identified 20 patients from our prospective tumor registry database that underwent transanal resection of early rectal cancers between 1988 and 1998.
  • All T1 lesions were well or moderately well differentiated, and none had lymphovascular invasion.
  • Four patients had postoperative adjuvant therapy (radiation alone, two; radiation and chemotherapy, two) for close margins after they refused an abdominal perineal resection.
  • This series suggests that transanal excision is a safe and effective treatment for selected early low rectal cancers with favorable histology.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Aged. Anastomosis, Surgical. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Chemotherapy, Adjuvant. Colon / surgery. Colostomy. Databases as Topic. Female. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local. Neoplasm Staging. Perineum / surgery. Postoperative Complications / surgery. Prospective Studies. Radiotherapy, Adjuvant. Registries. Safety. Survival Rate

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  • (PMID = 10993607.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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16. Fujita T, Kawasaki K, Ohno M, Kanaji S, Kobayashi I, Ueno K, Tsuchida S, Osawa M, Fujino Y, Kanbara Y, Nakamura T: [A successfully resected case of rectal cancer with liver metastases treated with mFOLFOX6 and bevacizumab]. Gan To Kagaku Ryoho; 2009 Apr;36(4):663-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A successfully resected case of rectal cancer with liver metastases treated with mFOLFOX6 and bevacizumab].
  • Colonoscopy revealed type 2 tumor at rectum.
  • Computed tomography (CT)demonstrated lymph node metastasis in front of sacrum and two low density areas which were suspected metastases in the liver.
  • The patient was diagnosed stageIV rectal cancer and resected primary focus and lymph node metastasis.
  • [ Ra-RS, ant, type 2, moderately differentiated adenocarcinoma, ly1, v3, pSE, pN2, sH1(Grade C), sP0, pM1(No. 270)]without liver resection.
  • The level of CEA decreased to normal level and CT revealed a partial response after 4 cycles of systemic chemotherapy.
  • Histological response was Grade 2 at liver metastases.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Rectal Neoplasms / drug therapy. Rectal Neoplasms / pathology
  • [MeSH-minor] Antibodies, Monoclonal, Humanized. Bevacizumab. Carcinoembryonic Antigen / blood. Fluorouracil / therapeutic use. Humans. Immunotherapy. Leucovorin / therapeutic use. Male. Organoplatinum Compounds / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 19381044.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Carcinoembryonic Antigen; 0 / Organoplatinum Compounds; 2S9ZZM9Q9V / Bevacizumab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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17. Mendenhall WM, Zlotecki RA, Snead FE, George TJ Jr, Marsh RD, Mendenhall CM, Rout WR: Radiotherapy in the treatment of resectable rectal adenocarcinoma. Am J Clin Oncol; 2009 Dec;32(6):629-38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiotherapy in the treatment of resectable rectal adenocarcinoma.
  • The goal of treatment is to cure whereas maintaining sphincter function and minimizing toxicity.
  • Although the mainstay of the treatment is surgery, radiotherapy (RT) is used in a substantial proportion of patients depending on the location and extent of the tumor.
  • The aim of this article is to discuss the role of RT in patients with resectable rectal adenocarcinoma.
  • Results show that patients with T1N0 exophytic, well to moderately differentiated, mobile tumors < or = 3 cm in diameter may be treated with either transanal excision or endocavitary RT.
  • The advantages of endocavitary RT are that it is an outpatient procedure requiring, at most, local anesthesia and is suitable for elderly, infirm patients.
  • The disadvantage is that few of these treatment units are available.
  • The addition of concomitant chemotherapy probably enhances downstaging and may improve the likelihood of sphincter preservation.
  • Patients with T3 and/or N1 rectal cancers have a relatively high probability of local-regional recurrence after surgery alone.
  • Preoperative RT and postoperative RT combined with adjuvant chemotherapy have been shown to significantly reduce the risk of local-regional recurrence and improve survival.
  • Whether preoperative RT alone or combined with chemotherapy is more efficacious than postoperative chemoradiation remains unclear.
  • Depending on tumor location and extent, adjuvant RT may improve the probability of local-regional control and survival for patients with locally advanced rectal adenocarcinomas.
  • [MeSH-major] Rectal Neoplasms / radiotherapy

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  • (PMID = 19593081.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 90
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