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Items 1 to 35 of about 35
1. Butte JM, Torres J, Duarte I, Zúñiga A: [Composite tumor of the colon with liver metastases]. Cir Esp; 2007 Aug;82(2):128-30
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  • [Title] [Composite tumor of the colon with liver metastases].
  • [Transliterated title] Tumor mixto del colon con metástasis hepáticas.
  • Treatment is similar to that of adenocarcinomas.
  • A computed tomography (CT) scan showed a tumor at the splenic flexure bowel and 2 hepatic nodules, suggesting metastases.
  • Preoperative biopsies confirmed an adenocarcinoma.
  • Histological analysis showed moderately differentiated tubular adenocarcinoma combined with a poorly differentiated neuroendocrine carcinoma and metastases in 25 of 28 lymph nodes.
  • The 2 hepatic metastases showed areas of poorly differentiated neuroendocrine carcinoma.
  • The patient is currently asymptomatic and is undergoing chemotherapy.
  • [MeSH-minor] Adult. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 17785149.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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2. Sheng LM, Zhang LZ, Xu HM, Zhu Y: Ascending colon adenocarcinoma with tonsillar metastasis: a case report and review of the literature. World J Gastroenterol; 2008 Dec 14;14(46):7138-40
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  • [Title] Ascending colon adenocarcinoma with tonsillar metastasis: a case report and review of the literature.
  • A 53-year-old man presented with painless left palatine tonsillar swelling and a cervical mass following right hemicolectomy for an ascending colon adenocarcinoma.
  • A punch biopsy was taken for histological examination which showed a moderately-differentiated adenocarcinoma.
  • The patient was treated with palliative radiotherapy and chemotherapy.
  • [MeSH-major] Adenocarcinoma / pathology. Colon, Ascending / pathology. Colonic Neoplasms / pathology. Tonsillar Neoplasms / diagnosis. Tonsillar Neoplasms / secondary
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Drug Therapy. Humans. Male. Middle Aged. Prognosis. Radiotherapy

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  • (PMID = 19084924.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 23
  • [Other-IDs] NLM/ PMC2776847
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3. Shin EK, Takizawa BT, Masters L, Shahabi S: The role of chemotherapy and prophylactic bilateral oophorectomy in a case of colorectal adenocarcinoma with ovarian metastases. Yale J Biol Med; 2001 Mar-Apr;74(2):101-5
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  • [Title] The role of chemotherapy and prophylactic bilateral oophorectomy in a case of colorectal adenocarcinoma with ovarian metastases.
  • On exploratory laparotomy, the mass was found to be a moderately differentiated adenocarcinoma of the sigmoid colon with metastasis to the left ovary.
  • If the nature of the primary tumor is uncertain and the initial response to chemotherapy is poor, the patient's prognosis will also he poor.
  • Though controversy exists regarding the role of prophylactic bilateral oophorectomy during resection for primary colorectal cancer, later confusion can be avoided by performing this procedure when the colorectal carcinoma is first diagnosed.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Ovarian Neoplasms / secondary. Ovariectomy. Sigmoid Neoplasms / drug therapy. Sigmoid Neoplasms / surgery

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  • (PMID = 11393261.001).
  • [ISSN] 0044-0086
  • [Journal-full-title] The Yale journal of biology and medicine
  • [ISO-abbreviation] Yale J Biol Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2588692
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4. Nakamura Y, Fujiwara H, Sonoyama T, Ochiai T, Shimizu T, Ichikawa D, Okamoto K, Sakakura C, Ueda Y, Itoi H, Otsuji E, Hagiwara A, Yamagishi H, Mitsuishi Y, Kishida T: [A case of unresectable multiple liver metastases from colon cancer successfully treated by hepatic arterial infusion chemotherapy and systemic immunotherapy (IFNANK) followed by hepatic resection]. Gan To Kagaku Ryoho; 2004 Oct;31(11):1812-4
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  • [Title] [A case of unresectable multiple liver metastases from colon cancer successfully treated by hepatic arterial infusion chemotherapy and systemic immunotherapy (IFNANK) followed by hepatic resection].
  • The patient was a 76-year-old man, diagnosed with sigmoid colon cancer with unresectable multible liver metastases.
  • After sigmoidectomy with D2 regional lymphnode dissection on June 21, 2002 (moderately differentiated adenocarcinoma, ss, n(-), H3, P0, M(-), Stage IV), intermittent hepatic arterial infusion chemotherapy using 5-FU (1,250 mg/body/3 hr) and CDDP (10 mg/body/30 min) was performed weekly for 23 times, and then biweekly for 15 times.
  • During the regional chemotherapy, IFNANK therapy was performed biweekly as systemic immunotherapy.
  • Thereafter, IFNANK therapy was continued without the chemotherapy.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Colonic Neoplasms / pathology. Immunotherapy / methods. Liver Neoplasms / secondary. Liver Neoplasms / therapy
  • [MeSH-minor] Aged. Cisplatin / administration & dosage. Drug Administration Schedule. Fluorouracil / administration & dosage. Humans. Infusions, Intra-Arterial. Interferon-alpha / pharmacology. Leukapheresis. Lymph Node Excision. Male

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  • (PMID = 15553724.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Interferon-alpha; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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5. Peng YF, Gu J: Synchronous colorectal and lung cancer: report of three cases. World J Gastroenterol; 2008 Feb 14;14(6):969-73
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  • We report three cases of patients with tumors located in the rectum, ascending colon, the lower lobe of the left lung, and the upper lobe of the right lung.
  • Pathological examination showed the colorectal cancer was a moderately differentiated adenocarcinoma and the lung cancer was a squamous cell carcinoma.
  • Surgical treatment and postoperative adjuvant chemotherapy for the lung cancer were different from those for colorectal cancer with pulmonary metastasis.

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  • (PMID = 18240362.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2687071
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6. Pilati P, Mocellin S, Rossi CR, Foletto M, Campana L, Nitti D, Lise M: Cytoreductive surgery combined with hyperthermic intraperitoneal intraoperative chemotherapy for peritoneal carcinomatosis arising from colon adenocarcinoma. Ann Surg Oncol; 2003 Jun;10(5):508-13
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  • [Title] Cytoreductive surgery combined with hyperthermic intraperitoneal intraoperative chemotherapy for peritoneal carcinomatosis arising from colon adenocarcinoma.
  • BACKGROUND: Hyperthermic intraoperative intraperitoneal chemotherapy (HIIC) has been recently proposed to treat peritoneal carcinomatosis arising from colon adenocarcinoma, which is usually regarded as a lethal clinical entity.
  • The purpose of this study was to evaluate the clinical outcome of this combined treatment.
  • METHODS: A retrospective study of 46 patients treated for peritoneal carcinomatosis from colon adenocarcinoma was performed.
  • The 2-year overall survival was 31%, and the median survival time and the median time to local disease progression were 18 and 13 months, respectively.
  • Survival and local disease control in patients with well- and moderately differentiated colon adenocarcinoma were significantly better than in those with poorly differentiated tumors.
  • CONCLUSIONS: Considering the dismal prognosis of this condition, HIIC seems to achieve encouraging results in a selected group of patients affected with resectable peritoneal carcinomatosis arising from colon adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma / secondary. Colonic Neoplasms / pathology. Hyperthermia, Induced. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Cell Differentiation. Cisplatin / administration & dosage. Combined Modality Therapy. Disease Progression. Female. Humans. Infusions, Parenteral. Male. Middle Aged. Mitomycin / administration & dosage. Prognosis. Survival Analysis. Treatment Outcome

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  • [CommentIn] Ann Surg Oncol. 2003 Jun;10(5):484-5 [12794010.001]
  • (PMID = 12794016.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin
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7. Hamilton K, Chiappori A, Olson S, Sawyers J, Johnson D, Washington K: Prevalence and prognostic significance of neuroendocrine cells in esophageal adenocarcinoma. Mod Pathol; 2000 May;13(5):475-81
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  • [Title] Prevalence and prognostic significance of neuroendocrine cells in esophageal adenocarcinoma.
  • Neuroendocrine differentiation is common in adenocarcinomas of the stomach and colon and may be associated with a slightly better prognosis in gastric adenocarcinoma.
  • Fifty-eight cases of esophageal adenocarcinoma (15 biopsies, 43 resections) from 52 patients were stained with a monoclonal antibody to chromogranin (CG).
  • Medical records were reviewed for tumor stage, response to therapy, and patient survival.
  • Thirty-two patients received radiation and chemotherapy, and four received radiation.
  • Tumors with CG-positive cells were moderately to poorly differentiated, and many consisted of large cribriform glands, similar to intestinal-type adenocarcinomas.
  • There was no difference in tumor stage at surgery or survival time between CG-positive and CG-negative tumors.
  • Low-grade dysplasia contained CG-positive cells in 11 of 14 cases (78.6%) and high-grade dysplasia in 3 of 6 cases.
  • In summary, neuroendocrine differentiation is common in BE and is retained in low- and high-grade dysplasia but is usually lost in esophageal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Neuroendocrine / pathology. Esophageal Neoplasms / pathology

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  • (PMID = 10824917.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 68485
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Chromogranins
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8. Kamoshita N, Makita F, Aiba M, Tokiniwa H, Nagashima T, Takeyoshi I, Ohwada S, Morishita Y: [Four cases of advanced colorectal cancer successfully treated with irinotecan plus 5-fluorouracil and l-leucovorin combination chemotherapy]. Gan To Kagaku Ryoho; 2005 Aug;32(8):1187-90
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  • [Title] [Four cases of advanced colorectal cancer successfully treated with irinotecan plus 5-fluorouracil and l-leucovorin combination chemotherapy].
  • We successfully treated four advanced colorectal cancers with irinotecan (CPT-11) plus 5-fluorouracil (5-FU) and l-leucovorin (l-LV) combination chemotherapy.
  • We diagnosed moderately-differentiated adenocarcinoma of the colon in two patients and of the rectum in two patients.
  • We recognized lymph node metastases in one patient and liver metastases in three patients at the time of operation.
  • After excision for a lesion of the colon or the rectum, all patients underwent a 2-week chemotherapy regimen (CPT-11 100 mg/m2/week + 5-FU 500 mg/m2/week + l-LV 10 mg/m2/week).
  • The progressive free survival time was 9.5 months and survival time ranged 5-18 months.
  • Grade 3 diarrhea and leukopenia were seen in one patient.
  • All other adverse reactions were mild (grade 1 or 2).
  • CPT-11/5-FU/l-LV combination chemotherapy appears to be effective for advanced and metastatic colorectal cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colorectal Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Agents, Phytogenic / adverse effects. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Leucovorin / administration & dosage. Leucovorin / adverse effects. Male. Middle Aged

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  • (PMID = 16121927.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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9. Ho L, Wassef H, Henderson R, Seto J: Renal metastasis from primary colon cancer on FDG PET-CT. Clin Nucl Med; 2009 Sep;34(9):596-7
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  • [Title] Renal metastasis from primary colon cancer on FDG PET-CT.
  • We report the PET-CT appearance of a metastasis from a primary colon cancer to the right kidney in an 84-year-old woman with a history of moderately differentiated adenocarcinoma of the cecum.
  • The patient underwent right hemicolectomy and chemotherapy.
  • Restaging PET-CT study, 4 months after her last chemotherapy, demonstrates a hypermetabolic soft-tissue mass in the inferior pole of the right kidney.
  • The pathology was consistent with metastatic colonic adenocarcinoma.
  • Renal metastasis from primary colon cancer is very rare.
  • [MeSH-minor] Aged, 80 and over. Female. Humans. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19692821.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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10. Mukai M, Oida Y, Mukoyama S, Okamoto Y, Ito I, Nakasaki H, Kawai K, Sato S, Makuuchi H: Efficacy of combination chemotherapy for stage IV colon cancer with extensive peritoneal dissemination and multiple liver metastases: a case report. Oncol Rep; 2002 Nov-Dec;9(6):1339-43
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  • [Title] Efficacy of combination chemotherapy for stage IV colon cancer with extensive peritoneal dissemination and multiple liver metastases: a case report.
  • A patient was diagnosed as having subacute ileus due to advanced cancer of the descending colon with multiple liver metastases and was treated by palliative left hemicolectomy.
  • Histopathological examination showed that the tumor was moderately differentiated adenocarcinoma.
  • Postoperative palliative chemotherapy was given with 5-FU and LV twice a month as 1 course, and he received a total of 3 courses.
  • When bilateral pleural effusions developed about 1 year postoperatively, CPT-11 was changed to CDGP.
  • Jaundice and massive ascites eventually developed, and he died about 1 year and 5 months postoperatively.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Liver Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy

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  • (PMID = 12375045.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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11. Yamamoto A, Ishibashi K, Tajima Y, Hatano S, Ishiguro T, Osawa T, Okada N, Kumamoto K, Yokoyama M, Haga N, Ishida H: [Successfully resected an isolated extraperitoneal metastasis of sigmoid colon cancer--a case report]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2644-6
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  • [Title] [Successfully resected an isolated extraperitoneal metastasis of sigmoid colon cancer--a case report].
  • We herein report an extremely rare operative case of an isolated extraperitoneal metastasis of colon cancer.
  • A female patient had undergone a sigmoidectomy for ileus due to sigmoid colon cancer when she was 40 years old.
  • Peritoneal metastasis, 5 mm in diameter, was on the sigmoid colon mesentery and she was histologically diagnosed as Stage IV.
  • She received fluorouracil-based adjuvant chemotherapy for 24 months.
  • Serum CEA increased in spite of giving UFT/LV, so we changed to mFOLFOX6 therapy.
  • Serum CEA decreased until it reached to a normal range after 9 courses, and stopped mFOLFOX6 therapy.
  • A histological examination of the tumor revealed a moderately differentiated adenocarcinoma similar to colon cancer.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Ovarian Neoplasms / secondary. Pelvic Neoplasms / secondary. Sigmoid Neoplasms / pathology. Sigmoid Neoplasms / surgery

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  • (PMID = 21224666.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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12. Melliou A, Theocharidis G, Helis L, Makridis J, Patakiouta F, Kouroussis C: Carcinoma of sigmoid colon after ureterosigmoidostomy. J BUON; 2005 Oct-Dec;10(4):551-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of sigmoid colon after ureterosigmoidostomy.
  • An unusual case of adenocarcinoma of the colon in a 49-year-old man is described.
  • A chest x-ray and thoracic computed tomography (CT) showed some nodules in both pulmonary fields, while an abdominal CT was normal.
  • The histology revealed a metastatic, moderately differentiated mucinous adenocarcinoma, probably of the bowel.
  • A sunsequent colonoscopy was non-disclosing and the patient was thought to suffer from a carcinoma of unknown origin and received 6 cycles of chemotherapy with carboplatin and 5-fluorouracil.
  • Five months after the end of chemotherapy he presented with an uncerated mass in the lower abdominal wall.

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  • (PMID = 17357215.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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13. mukai M, Moriya H, Himeno S, Oida Y, mukohyama S, Nishi T, Nakasaki H, Satoh S, Makuuchi H: Efficacy of oral UFT plus leucovorin therapy for colon cancer with ovarian and multiple liver metastases: report of two cases. Oncol Rep; 2001 Sep-Oct;8(5):1079-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of oral UFT plus leucovorin therapy for colon cancer with ovarian and multiple liver metastases: report of two cases.
  • Case 1: a patient was diagnosed as having ascending colon cancer with right ovarian metastasis, and underwent palliative right hemicolectomy plus oophorectomy.
  • The tumor was a well-differentiated adenocarcinoma with right ovarian metastasis, and the disease was classified as stage IV.
  • Oral chemotherapy with UFT plus LV was performed for about 3 years, and the patient is still being followed up with no recurrence at 5 years postoperatively.
  • Case 2: a patient was diagnosed as having incomplete large bowel obstruction caused by ascending colon cancer, and underwent curative right hemicolectomy.
  • The tumor was a moderately differentiated adenocarcinoma, and the disease was classified as stage II.
  • Since multiple liver metastases developed at 3 months postoperatively, oral chemotherapy with UFT plus LV was started.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Leucovorin / therapeutic use. Liver Neoplasms / drug therapy. Ovarian Neoplasms / drug therapy. Tegafur / therapeutic use. Uracil / therapeutic use
  • [MeSH-minor] Administration, Oral. Adult. Aged. Aged, 80 and over. Colectomy. Female. Humans. Neoplasm Staging. Ovariectomy. Postoperative Period. Remission Induction. Tomography, X-Ray Computed


14. Shibahara K, Endo K, Ikeda T, Sakata H, Sadanaga N, Morita M, Kakeji Y, Maehara Y: Colon metastasis 20 years after the removal of ovarian cancer: Report of a case. Surg Today; 2009;39(2):153-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colon metastasis 20 years after the removal of ovarian cancer: Report of a case.
  • This report describes the case of a patient who had undergone surgery to resect bilateral ovarian tumors and then presented with colon metastasis 20 years later.
  • She had been operated on for bilateral ovarian cancer in 1987 and was treated by postoperative adjuvant chemotherapy.
  • A biopsy of the lesion showed a group V, moderately differentiated adenocarcinoma.
  • Immunohistochemical staining during the pathological diagnosis showed the lesion to be colon metastasis from a serous papillary adenocarcinoma of the ovary.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / secondary. Ovarian Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Colonoscopy. Female. Humans. Tomography, X-Ray Computed

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  • [Cites] Am J Surg Pathol. 1998 Jul;22(7):805-15 [9669343.001]
  • [Cites] Surg Today. 2002;32(8):750-2 [12181732.001]
  • [Cites] Mod Pathol. 1996 Nov;9(11):1040-4 [8933513.001]
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  • (PMID = 19198996.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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15. Tanaka A, Honma K, Kondo H: [A case of cerebellum metastasis from colon cancer]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2242-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of cerebellum metastasis from colon cancer].
  • We report a case of cerebellum metastasis from transverse colon cancer, which had no evidence of recurrence in the thoracoabdominal region by chemotherapy and resection of liver and lung metastases after initial operation.
  • We performed a radical resection of transverse colon cancer (D2) in 2001.
  • The finding was moderately-differentiated adenocarcinoma, se, n1, ly1, v2, H0, P0, M0, stage IIIa.
  • Following the partial resection of the left lung, he received a treatment with 12 times of mFOLFOX6 and S-1+PSK.
  • However, drift and dizziness developed in April 2008, and cerebellum metastasis was diagnosed by MRI.
  • He underwent a partial resection of cerebellum tumor, radiation therapy and FOLFIRI.
  • He has been alive for 1 year after the treatment of the cerebellum metastasis, and there has been no evidence of recurrence in the thoracoabdominal region in 8 years after initial operation.
  • [MeSH-minor] Adenocarcinoma / pathology. Aged. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male

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  • (PMID = 20037383.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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16. Nakazaki T, Shibata K, Haseba M, Taniguchi H, Nakao S, Takahara O: [A case of liver metastasis of colon cancer responding remarkably to 5'-DFUR]. Gan To Kagaku Ryoho; 2004 Aug;31(8):1253-5
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  • [Title] [A case of liver metastasis of colon cancer responding remarkably to 5'-DFUR].
  • A 65-year-old man was referred to our hospital because of diarrhea due to sigmoid colon cancer.
  • Pathological findings showed moderately differentiated adenocarcinoma, s, n1.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antimetabolites, Antineoplastic / therapeutic use. Floxuridine / therapeutic use. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Aged. Colon, Sigmoid / surgery. Combined Modality Therapy. Drug Administration Schedule. Humans. Male. Remission Induction

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  • (PMID = 15332554.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 039LU44I5M / Floxuridine; V1JK16Y2JP / doxifluridine
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17. Kömürcü S, Ozet A, Oztürk B, Arpaci F, Altundağ MK, Tezcan Y: Colon cancer during pregnancy. A case report. J Reprod Med; 2001 Jan;46(1):75-8
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  • [Title] Colon cancer during pregnancy. A case report.
  • Histologic examination confirmed serosal and lymph node invasion of moderately differentiated mucous-secreting adenocarcinoma of the cecum and adenocarcinoma metastatic to the liver.
  • The patient received systemic chemotherapy.
  • CONCLUSION: Only 1 of 41 cases of colon cancer during pregnancy above the peritoneal reflection has been reported to be localized to the cecum.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colonic Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Cesarean Section. Embolization, Therapeutic. Fatal Outcome. Female. Gestational Age. Hepatic Artery. Humans. Liver Neoplasms / secondary. Pregnancy. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 11209639.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Yoshida N, Kochi M, Niide O, Watanabe Y, Mamiya T, Mochizuki S, Ohkubo T, Takayama T: [A case of advanced sigmoid colon cancer with peritoneal dissemination responding to FOLFOX4 therapy]. Gan To Kagaku Ryoho; 2008 Dec;35(13):2429-32
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  • [Title] [A case of advanced sigmoid colon cancer with peritoneal dissemination responding to FOLFOX4 therapy].
  • A 62-year-old woman complained of thin feces, lower blood and abdominal pain, and she was diagnosed as having bowel obstruction due to sigmoid colon cancer.
  • We established a diagnosis of unresectable sigmoid colon cancer accompanied by severe peritoneal dissemination and therefore performed only transverse colostomy in April, 2006.
  • Pathological examination of omental dissemination demonstrated moderately-differentiated adenocarcinoma.
  • FOLFOX4 therapy was started on April, 2006.
  • The partial response continued, and the serum CEA decreased 18.5 ng/mL after completion of 16 cycles, but grade 3 neuropathy occurred.
  • We started S-1 as second-line chemotherapy in May, 2007.
  • There was primary lesion re-growth after 4 cycles, so we changed to S-1+CPT-11 therapy.
  • The adverse events were grade 3 neuropathy and leucopenia throughout the course.
  • Chemotherapy is now continued on an outpatient basis, 24 months after the medical treatment started.
  • FOLFOX4 therapy is useful for patients with advanced colon cancer accompanied by peritoneal dissemination.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary. Sigmoid Neoplasms / drug therapy. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Carcinoembryonic Antigen / blood. Female. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Magnetic Resonance Imaging. Middle Aged. Neoplasm Staging. Organoplatinum Compounds / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 19098417.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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19. Sasaki Y, Natsuizaka M, Takano M, Suzuki M, Tsuyuguchi M, Nagasako T, Kawamura N, Kudo M, Tsuda I, Meguro J: [A case of primary adenocarcinoma of small intestine with multiple liver metastases successfully treated with mFOLFOX6]. Gan To Kagaku Ryoho; 2009 Nov;36(11):1927-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of primary adenocarcinoma of small intestine with multiple liver metastases successfully treated with mFOLFOX6].
  • Biopsy of the tumor was performed and pathological examination revealed adenocarcinoma.
  • Histopathological examination revealed moderately-differentiated adenocarcinoma of Bauhin's valve and the terminal ileum, and no adenocarcinoma was found in the cecum and ascending colon.
  • He was diagnosed with primary adenocarcinoma of the ileum with multiple liver metastases.
  • Chemotherapy with mFOLFOX6 was performed after surgical resection.
  • After 5 courses of chemotherapy, abdominal CT showed marked regression of the liver metastases, and tumor marker (CA19-9) was normalized from 1,100 U/mL to 36 U/mL.
  • Effectiveness of mFOLFOX6 for primary adenocarcinoma of small intestine is suggested.
  • [MeSH-major] Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ileal Neoplasms / pathology. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary

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  • (PMID = 19920403.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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20. Ishida H, Tatsuta M, Furukawa H, Ohta H, Hashimoto K, Hayashi N, Morimoto O, Ikeda M, Miya A, Masutani S, Kawasaki T, Satomi T, Yoshioka H, Hanai J: Multiple inflammatory pseudotumors mimicking liver metastasis from colon cancer: report of a case. Surg Today; 2000;30(6):530-3
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  • [Title] Multiple inflammatory pseudotumors mimicking liver metastasis from colon cancer: report of a case.
  • A 54-year-old man underwent an operation for colon cancer histologically diagnosed as moderately differentiated adenocarcinoma with clinical staging of Dukes C.
  • He was prescribed carmofur for adjuvant chemotherapy.
  • A follow-up computed tomography scan done 6 months later revealed two new low-density areas in the liver.
  • A diagnosis of metastatic adenocarcinoma from the previous colon cancer was presumed, based on the patient's history and radiological findings, and resection of the affected area of liver was performed.
  • IPT of the liver is a rare disease, for which no methods of diagnosis and treatment have been established, since it is difficult to distinguish IPT from hepatocellular carcinoma or metastatic carcinoma.
  • We describe this case with a review of the 101 cases of IPT documented in the Japanese literature, in the hope that it will contribute to the diagnosis and treatment of this unusual disease entity.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Granuloma, Plasma Cell / diagnosis. Liver Diseases / diagnosis. Liver Neoplasms / secondary

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  • [Cites] Acta Cytol. 1989 Mar-Apr;33(2):259-62 [2929226.001]
  • [Cites] Am J Clin Pathol. 1978 Feb;69(2):176-81 [629225.001]
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  • (PMID = 10883465.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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21. Handa R, Kato T, Miyake Y, Oshima K, Oshima S, Iijima S, Yamamoto H, Kurokawa E, Kikkawa N: [A long term survival case of advanced colon cancer with adjacent organ involvement and multiple liver metastases]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1795-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A long term survival case of advanced colon cancer with adjacent organ involvement and multiple liver metastases].
  • We report a long-term survival case of advanced colon cancer with adjacent organ involvement and multiple liver metastases.
  • An advanced colon cancer of the cecum was found with a colonoscopy.
  • Histopathologically, it was a moderately differentiated adenocarcinoma with a biopsy examination.
  • Abdominal CT showed advanced colon cancer with adjacent organ involvement and multiple liver metastases.
  • He received right hemi-colon resection and right hepatic lobectomy.
  • The patient was followed by 8 courses of adjuvant chemotherapy with 5-FU.
  • [MeSH-major] Adenocarcinoma / secondary. Cecal Neoplasms / pathology. Liver Neoplasms / secondary
  • [MeSH-minor] Chemotherapy, Adjuvant. Colectomy. Fluorouracil / therapeutic use. Hepatectomy. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Survivors

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  • (PMID = 17212110.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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22. Pizzirusso F, Gillet JP, Fobe D: Isolated spleen metastatic involvement from a colorectal adenocarcinoma complicated with a gastrosplenic fistula. A case report and literature review. Acta Chir Belg; 2004 Apr;104(2):214-6
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  • [Title] Isolated spleen metastatic involvement from a colorectal adenocarcinoma complicated with a gastrosplenic fistula. A case report and literature review.
  • We present the case of a 66-year-old man with a moderately differentiated adenocarcinoma of the left colon and isolated spleen metastases, complicated with a gastrosplenic fistula.
  • The patient underwent a palliative segmental resection of the primitive colic tumour, as no curative treatment could be offered in view of the spleen involvement.
  • Adjuvant chemotherapy was started.
  • After a few chemotherapy treatments, he developed a gastrosplenic fistula which required the resection of the spleen and the greater gastric curvature together.
  • At the end of the chemotherapy course, all carcinologic features had also disappeared.
  • [MeSH-major] Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Gastric Fistula / etiology. Splenic Diseases / etiology. Splenic Neoplasms / secondary. Stomach Neoplasms / secondary

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  • (PMID = 15154583.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 9
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23. Mercier I, Vuolo M, Jasmin JF, Medina CM, Williams M, Mariadason JM, Qian H, Xue X, Pestell RG, Lisanti MP, Kitsis RN: ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer. Cell Cycle; 2008 Jun 1;7(11):1640-7
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  • [Title] ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer.
  • The ability of cells to escape apoptosis is critical for carcinogenesis as well as resistance to radiation and chemotherapy.
  • ARC is expressed predominantly in terminally differentiated cells such as cardiac and skeletal myocytes and neurons.
  • Recently, however, the abundance of ARC was noted to be markedly increased in the epithelium of primary human breast cancers compared with benign breast tissue and to confer chemo- and radiation-resistance.
  • In this study, we assessed the abundance and subcellular localization of ARC in 21 human colon cancer cell lines and in 44 primary human colon adenocarcinomas and adjacent benign colonic tissue.
  • ARC was present at high levels in most colon cancer cell lines and in almost all primary colon cancers compared with corresponding controls.
  • Levels of ARC in the cytoplasm were increased in well, moderately, and poorly differentiated cancers compared with benign tissue, while levels of nuclear ARC were increased only in moderately differentiated tumors.
  • These results demonstrate that ARC is a novel marker of human colon cancer and suggest that it may be a general feature of epithelial cancers.
  • [MeSH-major] Adenocarcinoma / metabolism. Apoptosis Regulatory Proteins / genetics. Biomarkers, Tumor / genetics. Colonic Neoplasms / metabolism. Muscle Proteins / genetics

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  • (PMID = 18469522.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA-098779; United States / NCI NIH HHS / CA / R01-CA-120876; United States / NCI NIH HHS / CA / R01-CA-80250; United States / NHLBI NIH HHS / HL / R01HL60665; United States / NHLBI NIH HHS / HL / R01HL61550; United States / NHLBI NIH HHS / HL / R01HL80607
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Biomarkers, Tumor; 0 / Muscle Proteins; 0 / NOL3 protein, human
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24. Takahashi S, Iiai T, Shimada Y, Kobayashi Y, Suda K, Iwaya A, Maruyama S, Tani T, Hatakeyama K: [A long-term survival case of far-advanced colon cancer with Virchow's lymph node and lung metastasis that responded to multidisciplinary therapy]. Gan To Kagaku Ryoho; 2009 Jan;36(1):127-9
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  • [Title] [A long-term survival case of far-advanced colon cancer with Virchow's lymph node and lung metastasis that responded to multidisciplinary therapy].
  • Under a diagnosis of advanced cecal colon cancer with metastasis to Virchow's and paraaortic lymph nodes and lungs, a laparoscopic-assisted ileocecal resection with D2 lymph node dissection was performed.
  • Histological examination of the resected specimens revealed moderately-differentiated adenocarcinoma which had invaded the terminal ileum.
  • After the operation, he received chemotherapy with 5-FU/l-LV(RPMI method), LV/UFT, FOLFOX, FOLFIRI in succession, and cancer aggravation was generally controlled.
  • He has survived for 3 years since operation, and shows good QOL under the treatment.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cecal Neoplasms / drug therapy. Cecal Neoplasms / pathology. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary
  • [MeSH-minor] Aged. Biopsy. Carcinoembryonic Antigen / blood. Combined Modality Therapy. Humans. Lymphatic Metastasis / pathology. Male. Neoplasm Staging. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19151578.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Carcinoembryonic Antigen
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25. Ogino T, Ohue M, Noura S, Seki Y, Goto K, Motoori M, Kishi K, Eguchi H, Yamada T, Miyashiro I, Tomita H, Ohigashi H, Yano M, Ishikawa O, Imaoka S: [A long-term survival case of advanced sigmoid colon cancer with massive metastases to the para-aortic lymph nodes]. Gan To Kagaku Ryoho; 2007 Nov;34(12):2056-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A long-term survival case of advanced sigmoid colon cancer with massive metastases to the para-aortic lymph nodes].
  • We report a long-term survival case of advanced sigmoid colon cancer with massive metastases to the para-aortic lymph nodes.
  • He underwent sigmoidectomy with D3 + para-aortic lymphadenectomy for advanced sigmoid colon cancer.
  • Histological examination showed a moderately differentiated adenocarcinoma, ss, ly2, v2, n4 (total 30/64, para-aortic lymph nodes 18/39).
  • From 6 months to 4 years after the operation, tegafur/uracil (UFT) was performed as chemotherapy.
  • Histological examination revealed metastases from colon cancer.
  • [MeSH-major] Aorta / drug effects. Aorta / pathology. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Tegafur / therapeutic use. Tomography, X-Ray Computed. Uracil / therapeutic use

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  • (PMID = 18219897.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 1-UFT protocol
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26. Matsutani T, Sasajima K, Suzuki S, Matsushita A, Maruyama H, Matsuda A, Miyamoto M, Yokoyama T, Sugiura A, Yanagi K, Nishi Y, Arai H, Wakabayashi H, Tajiri T: [A case of ascending colon cancer with local recurrence responding completely to alternating modified-FOLFOX6 and FOLFIRI regimens(modified-FIREFOX regimen)]. Gan To Kagaku Ryoho; 2009 Mar;36(3):505-7
Hazardous Substances Data Bank. LEUCOVORIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of ascending colon cancer with local recurrence responding completely to alternating modified-FOLFOX6 and FOLFIRI regimens(modified-FIREFOX regimen)].
  • A 58-year-old woman underwent right hemicolectomy with lymph node dissection(D2)for advanced ascending colon cancer which pathological examinations revealed to be moderately-differentiated adenocarcinoma.
  • She started adjuvant chemotherapy with oral administration of UFT-E(400 mg/day), but CEA and CA19-9 levels continued to elevate.
  • However, a recurrent tumor was not detected by computed tomography(CT)and endoscopic examinations.
  • After this therapy, repeated PET-CT showed that the abnormal FDG-uptake concentration had disappeared, leading to a complete response(CR).
  • The adverse event was grade 3 in leucopenia and grade 2 in gastrointestinal toxicity.
  • She had maintained CR for the 12 months since undergoing chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy
  • [MeSH-minor] Biomarkers, Tumor / blood. Camptothecin / analogs & derivatives. Camptothecin / therapeutic use. Female. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Middle Aged. Organoplatinum Compounds / therapeutic use. Positron-Emission Tomography. Recurrence. Remission Induction. Tomography, X-Ray Computed

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  • (PMID = 19295282.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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27. Fukuda Y, Fujio N, Mayumi K, Ihara T, Terakura M, Takatori H, Tsukazaki T, Koyama I, Tsukazaki Y, Osugi H: [A case of advanced descending colon cancer with peritoneal dissemination responding to weekly high-dose l-leucovorin/5-fluorouracil combination therapy]. Gan To Kagaku Ryoho; 2004 Jul;31(7):1105-8
Hazardous Substances Data Bank. LEUCOVORIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of advanced descending colon cancer with peritoneal dissemination responding to weekly high-dose l-leucovorin/5-fluorouracil combination therapy].
  • We report a case in which l-leucovorin/5-fluorouracil (l-LV/5-FU) combination therapy was remarkably effective for non-resectable advanced descending colon cancer with carcinomatous peritonitis.
  • A 65-year-old man complained of severe abdominal distension, abdominal pain and pulmonary failure, and was diagnosed as having ileus due to descending colon cancer.
  • During the laparotomy, we established a diagnosis of nonresectable descending colon cancer accompanied by severe peritoneal dissemination and therefore performed only double-barreled transverse colostomy.
  • Pathological examination of omental dissemination demonstrated moderately differentiated adenocarcinoma and cytology of ascites was class II.
  • The levels of serum CEA and CA19-9 were within the normal ranges. l-LV/5-FU therapy was initiated postoperatively.
  • Seven cycles of this chemotherapy regimen was performed with no apparent side effect during the treatment.
  • On abdominal computed tomography (CT), the primary lesion of the colon decreased 98% and there was no ascites found.
  • To date, there has not been any sign of recurrence during the 19 months of follow-up after this therapy, and we are currently discussing closure of the transverse colostomy.
  • This therapy may be useful for patients with advanced colon cancer accompanied by peritoneal dissemination.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Peritoneal Neoplasms / drug therapy
  • [MeSH-minor] Aged. Dose-Response Relationship, Drug. Drug Administration Schedule. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Male. Quality of Life

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  • (PMID = 15272595.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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28. Ishizaki M, Akiyama N, Tanaka S, Motegi M, Sasamoto H, Osawa H, Wada W, Nakajima M: [Long-term survival of a patient with postoperative liver metastasis of stage IVa gallbladder cancer responding to hepatic arterial infusion chemotherapy]. Gan To Kagaku Ryoho; 2001 Mar;28(3):395-8
Hazardous Substances Data Bank. EPIRUBICIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Long-term survival of a patient with postoperative liver metastasis of stage IVa gallbladder cancer responding to hepatic arterial infusion chemotherapy].
  • A 58-year-old man was diagnosed as having advanced gallbladder cancer (T4, P0, H0, N0, stage IVa) with direct invasion to the liver, transverse colon and duodenum.
  • Therefore, extended cholecystectomy and bile duct resection with a partial resection of the transverse colon and the duodenum were performed in March 1992.
  • Histopathological examination revealed moderately differentiated tubular adenocarcinoma of si, ly1, v1, hinf3, binf3, n0.
  • Repeated hepatic arterial infusion chemotherapy with 5-FU 500 mg/body/w, MMC 4 mg/body/2w and EPI 40 mg/body/4w was performed starting in January 1996.
  • Four months later, the lesions in the liver were reduced in size, and abdominal CT 10 months after the chemotherapy showed a partial response.
  • Repeated hepatic arterial infusion chemotherapy with the same regimen was performed again starting in March 1998.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Gallbladder Neoplasms / drug therapy. Liver Neoplasms / secondary

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  • Hazardous Substances Data Bank. MITOMYCIN C .
  • Hazardous Substances Data Bank. FLUOROURACIL .
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  • (PMID = 11265412.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 3Z8479ZZ5X / Epirubicin; 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
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29. Mizushima T, Ito T, Mizuno H, Souma Y, Kainuma S, Yamanaka H, Ozawa H, Kanou T, Nakamori Y, Iwase K: [A case of recurrent colon cancer responding completely to uracil/tegafur (UFT) plus oral leucovorin (LV) therapy]. Gan To Kagaku Ryoho; 2005 Dec;32(13):2129-31
Hazardous Substances Data Bank. LEUCOVORIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of recurrent colon cancer responding completely to uracil/tegafur (UFT) plus oral leucovorin (LV) therapy].
  • The patient was a 78-year-old woman who underwent right hemicolectomy with lymph node dissection (D 2) for cecal cancer in June 2003.
  • Histological diagnosis was moderately differentiated adenocarcinoma, ss, n(-), P 0, H 0, M (-), stage II.
  • Adjuvant chemotherapy was not conducted, and the patient was periodically observed after operation.
  • Systemic chemotherapy with UFT + Leucovorin was initiated under the diagnosis of local recurrence.
  • Only grade 1 body weight loss,pigmentation, pruritus, and anorexia were recognized during chemotherapy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Colonic Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols. Colectomy. Combined Modality Therapy. Drug Administration Schedule. Drug Combinations. Female. Humans. Leucovorin / administration & dosage. Lymph Node Excision. Remission Induction. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 16352943.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / UFT(R) drug; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q573I9DVLP / Leucovorin
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30. Tamura T, Mizuyama Y, Shinto O, Nishihara T, Nakagawa H, Ono Y: [A long-term survival case of unresectable intrahepatic cholangiocarcinoma treated with chemotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2732-4
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A long-term survival case of unresectable intrahepatic cholangiocarcinoma treated with chemotherapy].
  • An 83-year-old man commuting to our hospital with postoperative ascending colon cancer was pointed out an increase of CA19-9.
  • Pathologically, it was moderately differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Bile Duct Neoplasms / drug therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / drug therapy. Deoxycytidine / analogs & derivatives. Oxonic Acid / therapeutic use. Tegafur / therapeutic use
  • [MeSH-minor] Aged, 80 and over. Drug Combinations. Humans. Male. Treatment Outcome

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  • (PMID = 21224695.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0W860991D6 / Deoxycytidine; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; B76N6SBZ8R / gemcitabine
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31. Hobdy EM, Ciesielski TE, Kummar S: Unusual sites of colorectal cancer metastasis. Clin Colorectal Cancer; 2003 May;3(1):54-7
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present 2 separate cases of adenocarcinoma of the colon with metastasis to the chin and the bladder, both of which are unusual sites of colorectal cancer metastasis.
  • Patient 1 is a 77-year-old man who was diagnosed with adenocarcinoma of the colon, American Joint Committee on Cancer (AJCC) T4 N0 M0 (stage II), and underwent a right hemicolectomy.
  • Fourteen months later he developed a firm 2.5-cm mass involving the chin.
  • Excisional biopsy revealed moderately differentiated adenocarcinoma, consistent with the known colon primary tumor.
  • Patient 2 is a 75-year-old man who was diagnosed with AJCC T3 N1 M0 (stage III) adenocarcinoma of the colon and underwent sigmoid colectomy.
  • Ten years later, he was found to have transitional cell carcinoma involving retroperitoneal nodes with no identifiable bladder or ureteral primary, for which he received chemotherapy.
  • Eighteen months following this diagnosis, he developed hematuria and was found to have metastatic colon adenocarcinoma involving the bladder.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / pathology. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / secondary

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  • (PMID = 12777193.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Neagoe A, Chira O, Zaharia T, Cruciat C: Education and management of patients with familial adenomatous polyposis. Are we making progress? A case report. Rom J Gastroenterol; 2004 Dec;13(4):333-6
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The colonoscopy showed hundreds of polyps throughout the colon, and an ulcerative rectosigmoidian tumor.
  • Histopathological diagnosis revealed moderately differentiated adenocarcinoma.
  • Adjuvant chemotherapy was carried out.
  • Two of them were diagnosed with adenomatous polyposis - the first with classic FAP and the other one with the attenuated type (AFAP).
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyposis Coli. Colorectal Neoplasms / pathology. Patient Education as Topic

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  • (PMID = 15624032.001).
  • [ISSN] 1221-4167
  • [Journal-full-title] Romanian journal of gastroenterology
  • [ISO-abbreviation] Rom J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Romania
  • [Number-of-references] 18
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33. Blair S, Ellenhorn JD: Transanal excision for low rectal cancers is curative in early-stage disease with favorable histology. Am Surg; 2000 Sep;66(9):817-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Controversy still exists as to the optimal treatment of early-stage low rectal cancers.
  • All T1 lesions were well or moderately well differentiated, and none had lymphovascular invasion.
  • Four patients had postoperative adjuvant therapy (radiation alone, two; radiation and chemotherapy, two) for close margins after they refused an abdominal perineal resection.
  • This series suggests that transanal excision is a safe and effective treatment for selected early low rectal cancers with favorable histology.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Aged. Anastomosis, Surgical. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Chemotherapy, Adjuvant. Colon / surgery. Colostomy. Databases as Topic. Female. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local. Neoplasm Staging. Perineum / surgery. Postoperative Complications / surgery. Prospective Studies. Radiotherapy, Adjuvant. Registries. Safety. Survival Rate

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  • (PMID = 10993607.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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34. Yamaguchi Y, Ohshita A, Hironaka K, Emi M, Kawabuchi Y, Sakatani A, Arihiro K: Neoadjuvant therapy of rectal cancer using oral tegaful-uracil (UFT) plus concomitant radiotherapy--a case report. Hiroshima J Med Sci; 2005 Sep;54(3):87-91
Genetic Alliance. consumer health - Rectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoadjuvant therapy of rectal cancer using oral tegaful-uracil (UFT) plus concomitant radiotherapy--a case report.
  • A 59-year-old male patient with rectal cancer 2 cm in diameter (T2) at the peritoneal reflection with suspicious left lateral node metastasis was treated with 400 mg of preoperative oral uracil and tegaful (UFT) for 5 weeks, 5 days a week in combination with concomitant radiotherapy of 45 Gy per 25 fractions for 5 weeks.
  • After resting for another 5 weeks, colon fiberscopy, barium enema, and computed tomography revealed a trace of the primary tumor and a 40% shrinkage of the lateral metastasis.
  • The serum CEA level decreased to the normal range during treatment.
  • The adverse effects were nausea, bloody stool and elevation of transaminase, all at grade 1.
  • The preoperative treatment did not affect any operative procedures, and no postoperative complications occurred.
  • The surgical specimen showed that the rectal tumor had been remarkably shrunk by the preoperative treatment, to the level of a superficial type tumor.
  • Histological analysis indicated moderately differentiated adenocarcinoma cells that were present at only 2 mm in diameter in the mucosal layer, 6 mm in the submucosal layer, and 1 mm or less in the muscular layer with scar formation.
  • These results suggest that preoperative oral UFT plus concomitant radiotherapy may be a feasible, tolerable and effective treatment for patients with rectal cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy
  • [MeSH-minor] Administration, Oral. Humans. Male. Middle Aged. Neoadjuvant Therapy. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 16180702.001).
  • [ISSN] 0018-2052
  • [Journal-full-title] Hiroshima journal of medical sciences
  • [ISO-abbreviation] Hiroshima J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil
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35. Kojima K, Nakashima F, Boku A, Muroishi Y, Nakanishi I, Oda Y: Clinicopathological study of involvement of granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor in non-lymphohematopoietic malignant tumors accompanied by leukocytosis. Histol Histopathol; 2002 10;17(4):1005-16

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • GM-CSF mRNA was confirmed by using non-fixed cryopreserved tumor tissues in one case positive for GM-CSF.
  • G-CSF-positive cases were large cell carcinoma of the lung, adenocarcinoma of the colon, and adenocarcinoma of the stomach, and GM-CSF-positive cases were spindle cell carcinoma of the lung and malignant thymoma.
  • In the case with stomach carcinoma, the primary lesion showing moderately differentiated adenocarcinoma was negative, but the lung metastatic lesion showing less differentiated adenocarcinoma was G-CSF-positive.
  • In four cases, excluding one case which may have been markedly affected by chemotherapy, the bone marrow showed hyperplasia, and the number of the granulocyte series cells significantly increased.

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  • (PMID = 12371127.001).
  • [ISSN] 0213-3911
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / DNA Primers; 0 / RNA, Messenger; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
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