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1. De Potter P, Disneur D, Levecq L, Snyers B: [Ocular manifestations of cancer]. J Fr Ophtalmol; 2002 Feb;25(2):194-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ocular manifestations of cancer].
  • [Transliterated title] Manifestations oculaires des cancers.
  • Cancer may affect the eye and orbit as a direct result of metastatic neoplastic infiltration, compression, or circulating antibodies involving paraneoplastic retinal degeneration.
  • A metastatic tumor to the uvea is the most common form of an intraocular metastatic process.
  • The choroid is the most common site for uveal metastasis; metastases to the ciliary body, iris, retina, optic disk, and vitreous are rare.
  • Approximately one-third of patients have no history of primary cancer at the time of ocular diagnosis.
  • Breast and lung carcinomas for women and lung and gastrointestinal carcinomas for men most commonly metastasize to the eye and orbit.
  • The short-term prognosis for vision is usually good after an individualized therapeutic approach (chemotherapy, hormonal therapy, external beam radiotherapy, or plaque radiotherapy), but the systemic prognosis is poor.
  • Anecdotal therapeutic responses are described after systemic steroids, immunoglobulin injection, and plasmapheresis.
  • Recognition of their visual symptoms and ocular findings should alert the ophthalmologist to the possibility of cancer and systemic evaluation should be pursued.
  • [MeSH-major] Eye Neoplasms / secondary. Lymphoma / diagnosis. Paraneoplastic Syndromes
  • [MeSH-minor] Adult. Child. Choroid Neoplasms / diagnosis. Choroid Neoplasms / secondary. Diagnosis, Differential. Eyelid Neoplasms / diagnosis. Eyelid Neoplasms / secondary. Female. Humans. Iris Neoplasms / diagnosis. Iris Neoplasms / secondary. Lymphoma, Non-Hodgkin / diagnosis. Male. Melanoma / complications. Melanoma / diagnosis. Melanoma / secondary. Orbital Neoplasms / diagnosis. Orbital Neoplasms / secondary. Prognosis. Retinal Diseases / etiology. Retinal Neoplasms / diagnosis. Retinal Neoplasms / secondary. Visual Acuity. Vitreous Body

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  • (PMID = 11941243.001).
  • [ISSN] 0181-5512
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 103
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2. Rocha Filho FD, Lima GG, Ferreira FV, Lima MG, Hissa MN: Orbital metastasis as primary clinical manifestation of thyroid carcinoma--case report and literature review. Arq Bras Endocrinol Metabol; 2008 Dec;52(9):1497-500
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  • [Title] Orbital metastasis as primary clinical manifestation of thyroid carcinoma--case report and literature review.
  • Capillary thyroid carcinoma (PTC) is the most common neoplasm of thyroid.
  • Metastatic thyroid carcinoma rarely involves the orbit.
  • We reported an uncommon case of orbital metastasis of PTC.
  • The biopsy of the tumor in orbit revealed metastatic thyroid carcinoma.
  • Currently, the patient has been receiving palliative chemotherapy with Clodronate Disodium.
  • Although rare, thyroid carcinoma should be suspected in orbit metastasis.
  • [MeSH-major] Carcinoma, Papillary / secondary. Orbital Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 19197459.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 19
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3. Papadimitrakopoulou VA, Ginsberg LE, Garden AS, Kies MS, Glisson BS, Diaz EM Jr, Clayman G, Morrison WH, Liu DD, Blumenschein G Jr, Lippman SM, Schommer D, Gillenwater A, Goepfert H, Hong WK: Intraarterial cisplatin with intravenous paclitaxel and ifosfamide as an organ-preservation approach in patients with paranasal sinus carcinoma. Cancer; 2003 Nov 15;98(10):2214-23
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  • BACKGROUND: The objectives of this study were to determine the efficacy, organ-preservation rate, and safety of intraarterial (IA) cisplatin in combination with intravenous paclitaxel and ifosfamide in patients with locally advanced carcinoma of the paranasal sinuses who required orbital exenteration or major craniofacial resection for complete tumor resection.
  • Five of those 19 patients (26%) achieved a complete response (CR), 6 patients (32%) achieved a partial response, and 8 patients (42%) had stable disease or developed progressive disease.
  • Eye-sparing surgery followed by radiotherapy (RT) was feasible in 7 of 24 patients, RT was offered to only 7 patients, whereas 3 patients received chemotherapy and RT, 2 patients refused further therapy, 3 patients underwent craniofacial resection with orbitectomy, and 1 patient was treated systemically for metastatic disease.
  • At the completion of treatment, 14 of 23 patients (61%) with locally advanced disease were disease free, and the orbit was preserved in 21 of 24 patients (88%).
  • CONCLUSIONS: Despite the encouraging organ-preservation rate, the approach studied resulted in substantial toxicity, and more effective adjunctive therapy is needed.
  • Alternative approaches, including the integration of targeted therapy agents in induction chemotherapy regimens followed by concomitant chemotherapy and RT or eye-sparing surgery, need further exploration.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma / drug therapy. Paranasal Sinus Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Disease-Free Survival. Eye Enucleation. Female. Humans. Ifosfamide / administration & dosage. Infusions, Intra-Arterial. Infusions, Intravenous. Male. Middle Aged. Orbit / surgery. Paclitaxel / administration & dosage. Radiotherapy, Adjuvant. Treatment Outcome

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  • [Copyright] Copyright 2003 American Cancer Society.
  • (PMID = 14601092.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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4. Lee DS, Woo KI, Chang HR: T-cell lymphoma presenting as painful ophthalmoplegia. Korean J Ophthalmol; 2006 Sep;20(3):192-4
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  • Under the impression of nonspecific orbital inflammation, she was treated with oral prednisone with initial response.
  • A metastatic workup was performed without any evidence of extraorbital tumor.
  • The patient was recommended to be treated with chemotherapy, however, refused to take the treatment.
  • CONCLUSIONS: T-cell lymphoma in the orbit can present as painful ophthalmoplegia and take a rapid clinical course.
  • The disease should be regarded as one of the differential diagnosis for painful ophthalmoplegia refractory to corticosteroid therapy.
  • [MeSH-major] Lymphoma, T-Cell / complications. Ophthalmoplegia / etiology. Orbital Neoplasms / complications. Pain / etiology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17004636.001).
  • [ISSN] 1011-8942
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2908846
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5. Johnson TE, Toledano SR: Ganglioneuroblastoma metastatic to the orbit. Ophthal Plast Reconstr Surg; 2003 Jul;19(4):330-3
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  • [Title] Ganglioneuroblastoma metastatic to the orbit.
  • A 10-month-old girl presented with an extensive orbital and cranial metastatic lesion from an adrenal ganglioneuroblastoma.
  • Treatment with chemotherapy alone resulted in complete regression of the tumors with over 7 years of follow-up.
  • Good prognostic indicators included her young age at diagnosis, DNA index of tumor cells of 1.4, and the histologic subtype of neuroblastic tumor.
  • This is the first reported case of ganglioneuroblastoma metastatic to the orbit.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Ganglioneuroblastoma / secondary. Orbital Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Female. Humans. Infant. Nerve Tissue Proteins / analysis. Skull Neoplasms / diagnosis. Skull Neoplasms / drug therapy. Skull Neoplasms / secondary

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  • (PMID = 12878887.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Nerve Tissue Proteins
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6. Gerencer RZ, Patel U, Hunter C, Heffernan JT: The role of endoscopic sinus surgery in the diagnosis and treatment of metastatic orbital carcinoid tumors. Ear Nose Throat J; 2007 Mar;86(3):157-61
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  • [Title] The role of endoscopic sinus surgery in the diagnosis and treatment of metastatic orbital carcinoid tumors.
  • Carcinoid tumor metastatic to the orbit is a rare occurrence.
  • We report such a case in a patient with a carcinoid metastasis that was found in the medial rectus muscle.
  • The diagnosis was established via a transnasal endoscopic approach.
  • We also discuss the treatment of metastatic orbital carcinoid in the hope that we will increase awareness of the utility of transnasal endoscopy in facilitating both the diagnosis and treatment of posteromedial orbital pathology.
  • [MeSH-major] Carcinoid Tumor / secondary. Carcinoid Tumor / surgery. Endoscopy / methods. Orbital Neoplasms / secondary. Orbital Neoplasms / surgery
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Liver Neoplasms / drug therapy. Liver Neoplasms / pathology. Middle Aged

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  • (PMID = 17427777.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Bartley GB, Campbell RJ, Salomão DR, Bradley EA, Marsh WR, Bite U: Adrenocortical carcinoma metastatic to the orbit. Ophthal Plast Reconstr Surg; 2001 May;17(3):215-20
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  • [Title] Adrenocortical carcinoma metastatic to the orbit.
  • PURPOSE: To describe the clinical course and histopathologic features of a patient with adrenocortical carcinoma metastatic to the orbit.
  • Several metastases ensued, including a large tumor to the right superior lateral bony orbit with extension to the brain, temporalis fossa, and orbit proper.
  • The tumor was resected with the use of a combined neurosurgical, ophthalmic, and craniofacial approach.
  • The patient died of widespread metastatic disease 15 months after the orbital operation.
  • CONCLUSIONS: Metastasis to the orbit from adrenocortical carcinoma is rare.
  • Surgical resection is the treatment of choice, with adjunctive radiation therapy and chemotherapy in some cases.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Carcinoma / secondary. Orbital Neoplasms / secondary
  • [MeSH-minor] Adrenalectomy. Adult. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 11388389.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Lim K, Ilsen PF: Optic disk edema in a patient with non-Hodgkin's lymphoma: is there a metastasis to the brain? Optometry; 2001 Jan;72(1):25-35
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  • [Title] Optic disk edema in a patient with non-Hodgkin's lymphoma: is there a metastasis to the brain?
  • This case report will present the manifestations and treatment of non-Hodgkin's lymphoma and review the differential diagnoses of bilateral disk edema.
  • The patient had pulmonary nodules noted on a recent chest x-ray that were thought to be cancerous; this raised the suspicion of a metastasis to the brain or orbit.
  • The patient did not return until about 10 weeks later, at which time he presented with a history significant for newly-diagnosed intermediate-grade non-Hodgkin's lymphoma.
  • He had begun chemotherapy one month before the second examination at our clinic; methotrexate therapy for CNS metastasis had been provided at the time of the spinal taps.
  • The patient's disk swelling resolved completely by the end of his six months of chemotherapy.
  • CONCLUSION: This is a unique presentation of a patient at high risk for brain metastasis, in which laboratory and radiologic studies failed to provide adequate supportive evidence for the conclusions drawn from clinic observations.
  • Bilateral disk edema in a patient with a history of non-Hodgkin's lymphoma is strongly suggestive of a metastatic tumor to the brain causing increased intracranial pressure.
  • [MeSH-major] Brain Neoplasms / secondary. Lymphoma, Non-Hodgkin / complications. Papilledema / etiology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 11217003.001).
  • [ISSN] 1529-1839
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Brush M, Zhang J, Schuetze S, Sires B: Angiosarcoma metastatic to the orbit. Ophthal Plast Reconstr Surg; 2006 Jan-Feb;22(1):62-4
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  • [Title] Angiosarcoma metastatic to the orbit.
  • A 61-year-old woman developed metastatic angiosarcoma in her left orbit.
  • Diagnosis was confirmed with an incisional orbital biopsy and special markers.
  • Treatment and palliation involved the use of multiple cycles of paclitaxcel, doxorubicin, and ifosfamide along with adjuvant radiotherapy.
  • The measured outcome was tumor mass reduction and mortality.
  • The patient responded to the chemotherapy with reduction of the tumor mass.
  • However, the disease progressed off the medications.
  • Chemotherapy may be a useful palliative adjunct in the control of metastatic orbital angiosarcoma.
  • Chemotherapy is unlikely to be curative but useful and an adjunct to surgery and radiation therapy.
  • [MeSH-major] Breast Neoplasms / pathology. Hemangiosarcoma / secondary. Orbital Neoplasms / secondary
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16418673.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Buono LM, Silberschmidt A, Foroozan R, Savino PJ: Metastatic synovial sarcoma to the skull base and orbit. Am J Ophthalmol; 2002 Nov;134(5):785-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic synovial sarcoma to the skull base and orbit.
  • PURPOSE: To report a case of metastatic synovial sarcoma to the parasellar area and orbit.
  • METHODS: A 43-year-old woman with a history of a right forearm synovial sarcoma treated with excision, radiation, and chemotherapy 16 months previously presented with blurred vision of the right eye, pain with eye movement, epistaxis, and a right superior division cranial nerve III palsy.
  • Magnetic resonance imaging showed a right parasellar and right orbital apex mass.
  • RESULTS: Pathologic examination of the parasellar biopsy revealed metastatic synovial sarcoma.
  • At 6-month follow-up, the neuro-ophthalmic examination was unchanged, and repeat magnetic resonance imaging showed no recurrence of the tumor.
  • CONCLUSIONS: Metastatic synovial sarcoma should be added to the differential diagnosis of parasellar and orbital tumors.
  • [MeSH-major] Orbital Neoplasms / secondary. Sarcoma, Synovial / secondary. Skull Base Neoplasms / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Forearm. Humans. Magnetic Resonance Imaging

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  • (PMID = 12429268.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Tehrani AH, Heegaard S, Prause JU, Fledelius HC, Daugaard S: Liposarcoma metastatic to the orbit. Eur J Ophthalmol; 2003 Jan-Feb;13(1):108-12
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  • [Title] Liposarcoma metastatic to the orbit.
  • PURPOSE: To describe a patient with liposarcoma metastatic to the left orbit.
  • Trans-septal orbital biopsies showed liposarcoma.
  • The patient was initially treated with prednisolone and later received radio- and chemotherapy.
  • Despite treatment he lost vision of the left eye and died a few months later.
  • RESULTS: Histological examination of the orbital tumor revealed a spindle-cell liposarcoma similar to the primary tumor of the retroperitoneum.
  • CONCLUSIONS: Liposarcoma metastatic to the orbit is rare, but should be suspected in a patient with proptosis caused by a space-occupying lesion and a history of liposarcoma.
  • [MeSH-major] Liposarcoma / secondary. Orbital Neoplasms / secondary. Retroperitoneal Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Agents, Alkylating / therapeutic use. Combined Modality Therapy. Diplopia / etiology. Fatal Outcome. Humans. Ifosfamide / therapeutic use. Male. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Visual Acuity

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  • (PMID = 12635688.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; UM20QQM95Y / Ifosfamide
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12. Dutton JJ, Rose JG Jr, DeBacker CM, Gayre G: Orbital Ewing's sarcoma of the orbit. Ophthal Plast Reconstr Surg; 2000 Jul;16(4):292-300
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  • [Title] Orbital Ewing's sarcoma of the orbit.
  • PURPOSE: Ewing's tumor is a primary tumor of bone in childhood that only rarely involves the orbit.
  • Most such cases are metastatic from distant sites.
  • This tumor may be confused with other small round cell malignancies of childhood, and immunohistochemical studies are essential in making the diagnosis.
  • METHODS: We present two cases of Ewing's tumor of the orbit.
  • One was in a 22-year-old boy with an occult primary tumor in the frontal bone that became symptomatic after forehead trauma.
  • RESULTS: In most cases with orbital involvement, ophthalmic symptoms consist of proptosis, pain, and occasionally visual loss and motility restriction.
  • The diagnosis is typically unsuspected before histologic evaluation.
  • Electron microscopic and immunohistochemical analyses are essential in making the diagnosis and are necessary for all such small round cell tumors.
  • CONCLUSIONS: Ewing's sarcoma is a rare orbital tumor of bone mainly affecting children.
  • Local treatment relying on surgical extirpation and radiotherapy alone has proven inadequate, with 5-year survival rates of <10%.
  • The addition of chemotherapy has improved survival rates significantly to approximately 50%.
  • [MeSH-major] Orbital Neoplasms / diagnosis. Sarcoma, Ewing / diagnosis
  • [MeSH-minor] Biopsy. Child. Child, Preschool. Diagnosis, Differential. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 10923978.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
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13. Tehrani AY, Heegaard S, Prause JU, Fledelius HC, Daugaard S: Liposarcoma metastatic to the orbit. Eur J Ophthalmol; 2003 Jan - Feb 2003;13(1):108-112

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liposarcoma metastatic to the orbit.
  • PURPOSE: To describe a patient with liposarcoma metastatic to the left orbit.
  • Trans-septal orbital biopsies showed liposarcoma.
  • The patient was initially treated with prednisolone and later received radio- and chemotherapy.
  • Despite treatment he lost vision of the left eye and died a few months later.
  • RESULTS: Histological examination of the orbital tumor revealed a spindle-cell liposarcoma similar to the primary tumor of the retroperitoneum.
  • CONCLUSIONS: Liposarcoma metastatic to the orbit is rare, but should be suspected in a patient with proptosis caused by a space-occupying lesion and a history of liposarcoma. (Eur J Ophthalmol 2003; 13: 108-12).

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  • (PMID = 28252682.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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14. McCulley TJ, Yip CC, Bullock JD, Warwar RE, Hood DL: Cervical carcinoma metastatic to the orbit. Ophthal Plast Reconstr Surg; 2002 Sep;18(5):385-7
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  • [Title] Cervical carcinoma metastatic to the orbit.
  • PURPOSE: To describe a case of orbital metastasis from an undifferentiated pelvic tumor with probable cervical origination.
  • Detailed ophthalmologic examination, orbital CT and MRI, and orbital biopsy with histologic and immunohistochemical analysis.
  • Diplopia in downgaze developed shortly after hospitalization.
  • Orbital MRI and CT revealed a 1.2 x 1.6-cm mass immediately inferior and posterior to the right globe without bone involvement.
  • On biopsy, the mass had histology similar to that of the pelvic tumor.
  • On metastatic workup, lesions were found involving the left femoral head, liver, and spinal column, with adjacent lymphadenopathy.
  • Despite treatment with radiation and chemotherapy, the patient died several months later of causes related to the systemic disease.
  • CONCLUSIONS: Orbital metastasis of cancer originating in the cervix, despite its rarity, should be considered when an orbital mass of unknown cause is present.
  • [MeSH-major] Carcinoma / secondary. Orbital Neoplasms / secondary. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Diplopia / etiology. Female. Humans. Tomography, X-Ray Computed


15. Amato MM, Esmaeli B, Shore JW: Orbital rhabdomyosarcoma metastatic to the contralateral orbit: a case report. Ophthalmology; 2002 Apr;109(4):753-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital rhabdomyosarcoma metastatic to the contralateral orbit: a case report.
  • OBJECTIVE: To report a rare presentation of metastatic orbital rhabdomyosarcoma and the corresponding findings on magnetic resonance imaging (MRI).
  • RESULTS: A 29-year-old white man was diagnosed with rhabdomyosarcoma of the left sinus and orbit for which he was treated with chemotherapy and radiation.
  • Eighteen months after diagnosis, he returned with subacute right eye pain and dysmotility of his extraocular muscles.
  • Over the next 2 months, symptoms progressed, and proptosis developed.
  • A biopsy of right orbital tissues and the right medial rectus muscle was performed.
  • Special tissue typing confirmed metastatic alveolar rhabdomyosarcoma.
  • The patient underwent palliative radiation therapy and chemotherapy, but he ultimately died of disseminated disease.
  • Earlier recognition of orbital metastasis through radiographic and biopsy findings, along with prompt and aggressive treatment, may prevent fulminant spread of rhabdomyosarcoma.
  • [MeSH-major] Orbital Neoplasms / pathology. Orbital Neoplasms / secondary. Rhabdomyosarcoma / secondary
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 11927435.001).
  • [ISSN] 0161-6420
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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16. Odashiro AN, Leite LV, Oliveira RS, Tamashiro C, Pereira PR, Miiji LN, Odashiro DN, Burnier MN Jr: Primary orbital mesenchymal chondrosarcoma: a case report and literature review. Int Ophthalmol; 2009 Jun;29(3):173-7
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  • [Title] Primary orbital mesenchymal chondrosarcoma: a case report and literature review.
  • It is an aggressive neoplasm with a high tendency for late recurrence and occasional delayed distant metastasis.
  • Orbital MC is very rare, and only approximately 30 cases have been described in the literature.
  • We describe here one case of primary orbital MC.
  • Computed tomography (CT) scans of the orbit revealed a right intraconic lesion, with areas of calcification.
  • Histopathological analysis revealed that the tumor had a biphasic pattern, showing a combination of small cell malignancy and well-differentiated cartilage.
  • The patient received chemotherapy, and no metastatic disease was found at the 2-month follow-up.
  • CONCLUSION: Although rare, MC should be considered in the differential diagnosis of a well-circumscribed orbital lesion in young adults, especially when CT scans reveal areas of calcification within the tumor.
  • [MeSH-major] Chondrosarcoma, Mesenchymal / diagnosis. Orbital Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Antigens, CD / analysis. Antigens, CD / biosynthesis. Antigens, CD99. Calcinosis / diagnosis. Cartilage / metabolism. Cartilage / pathology. Cell Adhesion Molecules / analysis. Cell Adhesion Molecules / biosynthesis. Diagnosis, Differential. Drug Therapy. Humans. Immunohistochemistry. Male. Mesenchymal Stromal Cells / metabolism. Mesenchymal Stromal Cells / pathology. S100 Proteins / analysis. S100 Proteins / biosynthesis. Tomography, X-Ray Computed. Treatment Outcome

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  • [Cites] Surg Neurol. 1999 Jul;52(1):50-3 [10390173.001]
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  • (PMID = 18188507.001).
  • [ISSN] 1573-2630
  • [Journal-full-title] International ophthalmology
  • [ISO-abbreviation] Int Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD99; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / S100 Proteins
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17. Shields JA, Shields CL, Brotman HK, Carvalho C, Perez N, Eagle RC Jr: Cancer metastatic to the orbit: the 2000 Robert M. Curts Lecture. Ophthal Plast Reconstr Surg; 2001 Sep;17(5):346-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer metastatic to the orbit: the 2000 Robert M. Curts Lecture.
  • PURPOSE: To report the demographics and clinical features of a large series of patients with orbital metastasis.
  • METHODS: Retrospective chart review on 100 consecutive patients and a literature review on orbital metastasis.
  • RESULTS: Of 100 patients, the primary tumor site was breast in 53 (53%), prostate gland in 12 (12%), lung in 8 (8%), skin (melanoma) in 6 (6%), kidney in 5 (5%), gastrointestinal tract in 5 (5%), choroid (melanoma) in 2 (2%), parotid gland in 1 (1%), and adrenal gland (neuroblastoma) in 1 (1%).
  • Of patients in whom a detailed history was available, there was no history of cancer at the time of presentation in 19%.
  • In 10%, the primary tumor remained undetected despite systemic evaluation.
  • There were 36 male patients and 64 female patients whose mean age at diagnosis was 62 years (median 60 years, range 5 to 91 years).
  • The most frequent clinical findings were limited ocular motility (54%), proptosis (50%), and palpable mass (43%).
  • Treatment included chemotherapy, hormone therapy, irradiation, surgical excision, or observation, depending on clinical circumstances.
  • Among patients with sufficient follow-up, 95% died of metastasis, with overall mean survival of 15 months (median 15 months; range 3 to 96 months) after orbital diagnosis.
  • CONCLUSIONS: The most common primary cancers that metastasize to the orbit are breast, prostate gland, and lung cancer.
  • [MeSH-major] Carcinoma / secondary. Melanoma / secondary. Neoplasms / pathology. Neuroblastoma / secondary. Orbital Neoplasms / secondary. Sarcoma / secondary
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Tomography, X-Ray Computed


18. Font RL, Ray R, Mazow ML, Del Valle M: Mesenchymal chondrosarcoma of the orbit: a unique radiologic-pathologic correlation. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):219-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenchymal chondrosarcoma of the orbit: a unique radiologic-pathologic correlation.
  • PURPOSE: To report a unique radiologic-histopathologic correlation of mesenchymal chondrosarcoma of the orbit in a 24-year-old Asian woman.
  • CT showed a left orbital mass depicting a central radiolucent, nonenhancing component, and a denser peripheral enhancing portion.
  • Histopathologic examination of the orbital mass showed a biphasic pattern of a mesenchymal chondrosarcoma exhibiting features of a high-grade sarcoma with hemangiopericytoma pattern that corresponds to the radiopaque portion of the mass and areas of chondrosarcoma that correlated with the radiolucent component of the tumor.
  • The patient underwent exenteration of the left orbit followed by radiotherapy and chemotherapy.
  • The last follow-up (8 years, 1 month) disclosed no evidence of recurrence or metastatic disease.
  • The authors believe that recognizing the different radiologic features of the orbital tumor can help clinicians in establishing the correct preoperative diagnosis of this potentially lethal neoplasm.
  • [MeSH-major] Chondrosarcoma, Mesenchymal / pathology. Chondrosarcoma, Mesenchymal / radiography. Orbital Neoplasms / pathology. Orbital Neoplasms / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Asian Continental Ancestry Group. Chemotherapy, Adjuvant. Exophthalmos / etiology. Exophthalmos / radiography. Female. Follow-Up Studies. Humans. Orbit Evisceration. Radiotherapy, Adjuvant. Treatment Outcome. Young Adult

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  • (PMID = 19454935.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Kiratli H, Yilmaz PT, Yildiz ZI: Metastatic atypical carcinoid tumor of the inferior rectus muscle. Ophthal Plast Reconstr Surg; 2008 Nov-Dec;24(6):482-4
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  • [Title] Metastatic atypical carcinoid tumor of the inferior rectus muscle.
  • A 74-year-old man who had been treated for pulmonary atypical carcinoid tumor 3 years earlier developed diplopia.
  • Incisional biopsy of the affected muscle revealed metastatic atypical carcinoid tumor infiltration that immunostained positively for epithelial membrane antigen, synaptophysin, and chromogranin.
  • Systemic chemotherapy consisting of cisplatin and etoposide was prescribed to address the orbital tumor and a contemporaneously discovered hepatic locus.
  • This treatment provided a 2-year disease-free period with complete resolution of his ocular symptoms.
  • Although metastatic bronchogenic carcinoid tumor in the orbit, and in the inferior rectus muscle in particular, is highly unusual, this condition must be considered in the differential diagnosis of an isolated extraocular muscle enlargement in a patient with a history of systemic carcinoid tumor.
  • [MeSH-major] Carcinoid Tumor / secondary. Eye Neoplasms / secondary. Lung Neoplasms / pathology. Muscle Neoplasms / secondary. Oculomotor Muscles
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19033849.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Shields JA, Perez N, Shields CL, Singh AD, Eagle RC Jr: Orbital melanoma metastatic from contralateral choroid: management by complete surgical resection. Ophthalmic Surg Lasers; 2002 Sep-Oct;33(5):416-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital melanoma metastatic from contralateral choroid: management by complete surgical resection.
  • We discuss a clinicopathologic correlation of orbital metastasis from a contralateral choroidal melanoma wherein the orbital tumor was removed completely by surgical resection.
  • The tumor responded well but recurred after 9 years, necessitating enucleation.
  • In August 1999, 17 years after initial presentation, metastatic melanoma to liver, lung, and brain were found and the patient had a favorable response to chemotherapy and brain irradiation.
  • Five months later, in November 2000, an enlarging orbital mass was documented to be compressing the left optic nerve.
  • Complete surgical removal of the tumor was achieved by a superotemporal orbitotomy.
  • Histopathologically, the tumor was a malignant melanoma with features similar to the choroidal tumor.
  • The contralateral orbit can be the site of late metastasis from choroidal melanoma.
  • In rare instances, an orbital metastasis can be completely removed surgically without subjecting the patient to orbital irradiation.
  • [MeSH-major] Choroid Neoplasms / pathology. Melanoma / secondary. Orbital Neoplasms / secondary

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  • (PMID = 12358296.001).
  • [ISSN] 1082-3069
  • [Journal-full-title] Ophthalmic surgery and lasers
  • [ISO-abbreviation] Ophthalmic Surg Lasers
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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21. Chastagner P: [Malignant extraconal tumors of the orbit in childhood]. Neurochirurgie; 2010 Apr-Jun;56(2-3):281-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant extraconal tumors of the orbit in childhood].
  • [Transliterated title] Les tumeurs malignes extraconiques de l'orbite chez l'enfant.
  • Malignant extraconal orbital tumors are very rare during childhood and must be referred as soon as possible to a highly specialized center to be managed by a multidisciplinary team.
  • Both diagnosis and treatment must be undertaken as soon as possible.
  • The course of these malignant tumors can be acute and can jeopardize the function of the eye or be life-threatening, especially in the event of metastatic locations.
  • Sometimes diagnosis should be clear with the association of an orbital tumor and deterioration of the general health status favoring metastatic disease.
  • Most metastatic neuroblastomas present such clinical symptoms in young children.
  • Today both CT and MRI are highly valuable in assessing the diagnosis and starting the management of these tumors.
  • Biopsy is mandatory to confirm the diagnosis.
  • Among the primitive tumors, soft tissue sarcomas, especially rhabdomyosarcomas, are the most frequent.
  • The diagnosis is suggested when the onset of the disease is acute and the course is rapid.
  • Most respond to neoadjuvant chemotherapy.
  • In the event of a residual tumor, local treatment is indicated so that surgery and/or radiotherapy are used as second-line treatment.
  • It can be satisfactory (Langerhans' cell histiocytosis, lymphoma, meningioma, infantile fibrosarcoma) or poor (metastatic tumor, rhabdoid tumor).
  • [MeSH-major] Orbital Neoplasms / pathology. Orbital Neoplasms / surgery
  • [MeSH-minor] Child. Child, Preschool. Combined Modality Therapy. Exophthalmos / etiology. France. Humans. Incidence. Infant. Male. Neoplasm Metastasis. Prognosis. Rhabdomyosarcoma / epidemiology. Rhabdomyosarcoma / surgery. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20303550.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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22. Chew R: Destruction of the orbit and globe by recurrence of basal cell carcinoma. Optometry; 2007 Jul;78(7):344-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Destruction of the orbit and globe by recurrence of basal cell carcinoma.
  • Several treatment options exist, including surgical excision, cryotherapy, radiotherapy, laser surgery, chemotherapy, and photodynamic therapy.
  • The average rate of recurrence is 5%, depending on the type of BCC, the size, the location, and therapeutic approach.
  • At that time the patient was treated with surgical excision and radiotherapy.
  • They found that the BCC had infiltrated the right globe and the retro-orbital region and probably invaded the adjacent bony margins.
  • He had extensive surgery to remove the tumor and subsequent skin grafting.
  • However, there is no procedure that has a zero recurrence rate.
  • BCC, although rarely metastatic, can be invasive.
  • This case underscores the importance of proper follow-up protocol for all surgical patients as well as patient education that reinforces the importance of follow-up care and self-monitoring on the part of the patient.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Orbit / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Ophthalmologic Surgical Procedures / methods. Tomography, X-Ray Computed

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  • (PMID = 17601572.001).
  • [ISSN] 1529-1839
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Holland D, Maune S, Kovács G, Behrendt S: Metastatic tumors of the orbit: a retrospective study. Orbit; 2003 Mar;22(1):15-24

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic tumors of the orbit: a retrospective study.
  • PURPOSE: To present the clinical features and facts on prognosis, therapy and diagnostics of orbital metastases treated in the Orbital Center Kiel.
  • METHODS: We reviewed the records of 20 patients with orbital metastases (ca.
  • 2% of all orbital patients seen in a 10-year period).
  • RESULTS: The mean age at first manifestation of orbital symptoms was 64 years.
  • On average, 64 months was the period of time between the onset of the primary disease and orbital manifestation.
  • The sites of the primary tumors were breast (8), choroid (2), prostate (2), gastrointestinal tract (3), lung (2), urinary bladder (1), Schmincke tumor of the throat (1) and unknown origin (1).
  • Although the majority (16/20) were treated by chemotherapy, radiotherapy or surgery, 19 patients died after a mean survival time of 14.7 months.
  • CONCLUSION: Orbital metastases remain an unfavorable prognostic factor, but the diagnosis and treatment are still important in order to prevent loss of vision and improve the patient's quality of life.
  • [MeSH-major] Orbital Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Prognosis. Quality of Life. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 12759863.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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24. Kuo SC, Hsiao SC, Chiou CC, Chen FF, Huang KC: Metastatic carcinoma of the breast: a case with the unusual presentation of unilateral periorbital edema. Jpn J Ophthalmol; 2008 Jul-Aug;52(4):305-7
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  • [Title] Metastatic carcinoma of the breast: a case with the unusual presentation of unilateral periorbital edema.
  • BACKGROUND: Metastasis of mammary cancer involving the orbit is common, and it typically presents with enophthalmos and restrictions of ocular motility.
  • CASE: Metastasis of breast cancer involving unilateral eyelid edema was diagnosed in a 66-year-old woman.
  • The diagnosis was based on the histopathologic features of carcinomatous cells in the excised specimen.
  • OBSERVATIONS: Insidious, progressive unilateral upper and lower eyelid swelling of the right eye disappeared after one cycle of palliative chemotherapy.
  • Neither restriction nor proptosis developed in the whole course.
  • CONCLUSIONS: Possible metastasis should be considered as a possible etiology of unilateral eyelid edema, even without a palpable mass or limitation of ocular motility.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / secondary. Edema / diagnosis. Eyelid Diseases / diagnosis. Orbital Neoplasms / secondary
  • [MeSH-minor] Aged. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Cyclophosphamide / administration & dosage. Female. Humans. Keratins / analysis. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Taxoids / administration & dosage. Tegafur / administration & dosage. Trastuzumab

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  • (PMID = 18773269.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Taxoids; 1548R74NSZ / Tegafur; 15H5577CQD / docetaxel; 68238-35-7 / Keratins; 8N3DW7272P / Cyclophosphamide; P188ANX8CK / Trastuzumab
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25. Schick U, Lermen O, Hassler W: Management of orbital metastases. Zentralbl Neurochir; 2006 Feb;67(1):1-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of orbital metastases.
  • True metastatic disease to the orbit is rare.
  • We present an overview of the treatment and clinical outcome of 11 orbital metastases, carried out in our center from 1995 to 2002.
  • The surgical approach was determined by the location and type of the lesion.
  • The most common primary cancers that metastasized to the orbit were lung cancer, and breast cancer.
  • Three patients showed recurrent tumor growth despite chemo- and/or radiotherapy.
  • The mean survival time was 15 months after diagnosis of orbital metastases.
  • A multidisciplinary treatment is required.
  • Therapeutic options include surgical biopsy, debulking or excision, hormonal therapy, chemotherapy, and radiation therapy.
  • [MeSH-major] Neurosurgical Procedures. Orbital Neoplasms / secondary. Orbital Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 16518744.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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26. Shukla RC, Singh PK, Senthil S, Pathak R: Esthesioneuroblastoma: a case report. Nepal Med Coll J; 2010 Jun;12(2):128-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Esthesioneuroblastoma (olfactory neuroblastoma) is an uncommon neuroectodermal tumor.
  • Its biological activity ranges from indolent growth to local recurrence and rapid widespread metastasis.
  • Treatment options consist of surgical resection followed by radiation therapy for primary lesions and the addition of chemotherapy for advanced, recurrent, or metastatic lesions.
  • X-ray PNS showed soft tissue mass in the nasal cavity with destruction of nasal septum, intense periosteal reaction with destruction of right maxillary wall and extension to right orbit.
  • CT scan of paranasal sinuses showed 8.5 x 4.9 x 7.8 cms irregularly marginated heterogeneous iso- to hyper dense soft tissue mass lesion with extensive adjacent bony destruction and spiculated periosteal reaction involving bilateral nasal cavity and anterior cranial fossa.
  • The patient received radiotherapy and chemotherapy.
  • The modified Kadish staging system, lymph node status, treatment modality, and age are useful predictors of survival in patients who present with esthesioneuroblastoma.
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Male. Nasal Obstruction / etiology. Tomography, X-Ray Computed

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  • (PMID = 21222414.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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27. Kurli M, Finger PT, Schneider S, Tena LB: Eyelid-sparing adjuvant radiation therapy for renal cell carcinoma. Ophthalmologica; 2006;220(3):198-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid-sparing adjuvant radiation therapy for renal cell carcinoma.
  • PURPOSE: To describe the use of debulking surgery with adjuvant external beam irradiation as an eyelid-sparing treatment for renal cell carcinoma.
  • METHODS: A 63-year-old male presented with a right upper lid tumor.
  • He had a history of renal cell carcinoma and pulmonary metastasis treated with surgery and systemic chemotherapy.
  • The eyelid tumor was biopsied, followed by debulking surgery and external beam radiation therapy to treat this metastatic tumor.
  • RESULTS: Histopathological evaluation of the excised tumor revealed a metastatic renal cell carcinoma, clear cell type.
  • CONCLUSIONS: Meta static renal cell carcinoma presenting in the eye and orbit can be the initial manifestation of the primary tumor.
  • It is important to include this tumor in the differential diagnosis of recurrent eyelid lesions.
  • Debulking surgery followed by external beam radiation therapy can be used to control the tumor with an eyelid-sparing cosmetic result.
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Radiotherapy, Adjuvant

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  • (PMID = 16679797.001).
  • [ISSN] 0030-3755
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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28. Castro Alonso FJ, Carbonell Ruiz P, Palomar Gómez A: [Acute proptosis as first symptom of a lung carcinoma]. Arch Soc Esp Oftalmol; 2000 Mar;75(3):195-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Proptosis aguda como primera manifestación de un carcinoma de pulmón.
  • PURPOSE/METHOD: We present the case of a 57-year-old patient who was visited in our ophthalmology department complaining of acute right ocular proptosis, fever and malaise.
  • The clinical, ophthalmic and radiologic examination showed the presence of an extraconal orbital tumor as the cause of this exophthalmos.
  • RESULTS/CONCLUSION: Further complementary studies revealed a small cell carcinoma of the lung metastatic to the right orbit.
  • We report the excellent response to chemotherapy both of the primary lung neoplasm and the orbital metastasis.
  • [MeSH-major] Exophthalmos / etiology. Lung Neoplasms / pathology. Orbital Neoplasms / secondary
  • [MeSH-minor] Acute Disease. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Male. Middle Aged

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  • (PMID = 11151149.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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29. Shields CL, Honavar S, Shields JA, Demirci H, Meadows AT: Vitrectomy in eyes with unsuspected retinoblastoma. Ophthalmology; 2000 Dec;107(12):2250-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MAIN OUTCOME MEASURES: The two main outcome measures were ultimate patient management and the development of retinoblastoma metastasis.
  • RESULTS: Of more than 900 consecutive patients with retinoblastoma managed on the Ocular Oncology Service at Wills Eye Hospital in Philadelphia, 11 (1%) had prior vitrectomy in an eye with viable tumor before referral to us for suspected retinoblastoma.
  • Anterior chamber tumor cells were clinically visible in four eyes (36%), hyphema in two eyes (18%), and iris neovascularization in two eyes (18%).
  • Adjuvant treatment was delivered in 10 patients (91%), using orbital radiotherapy in nine patients (82%) and chemotherapy in nine patients (82%).
  • The vitrectomy ports, Tenon's fascia, cut end of the optic nerve, and orbit were free of tumor.
  • Of the 10 patients who received prophylactic chemotherapy, radiotherapy, or both in addition to enucleation for prevention of retinoblastoma metastasis, none (0%) experienced metastasis or orbital recurrence during the mean follow-up of 7 years (range, 0.2-24 years) from the time of retinoblastoma diagnosis.
  • However, one patient was referred to us after the development of metastatic retinoblastoma, and despite aggressive chemotherapy and radiotherapy after enucleation, died 24 months later.
  • If vitrectomy is performed in an eye with unsuspected retinoblastoma, enucleation combined with adjuvant chemotherapy, radiotherapy, or both without delay is advised to prevent systemic tumor dissemination.
  • [MeSH-major] Retinal Neoplasms / diagnosis. Retinoblastoma / diagnosis. Vitrectomy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Combined Modality Therapy. Endophthalmitis / surgery. Eye Enucleation. Eye Infections, Parasitic / surgery. Female. Humans. Male. Neoplasm Invasiveness. Prognosis. Retrospective Studies. Vitreous Hemorrhage / surgery

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  • (PMID = 11097606.001).
  • [ISSN] 0161-6420
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
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30. Mozet C, Stumpp P, Mekonnen B, Dietz A: [Therapeutic options in sinunasal adenoid cystic carcinomas--a case report and review]. Laryngorhinootologie; 2009 Oct;88(10):631-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Therapeutic options in sinunasal adenoid cystic carcinomas--a case report and review].
  • [Transliterated title] Behandlungsstrategie bei sinunasalen adenoidzystischen Karzinomen--Ein Fall mit Literaturübersicht.
  • We discuss both, surgical margins and functional results preoperatively and postoperative options for adjuvant therapy.
  • The former opinion of a resistance of ACC towards chemotherapy or irradiation seems to be outdated, even though consensus about therapeutic strategies is still missing.
  • MATERIAL AND METHODS: We discuss therapeutic options and compare data from literature regarding the best adjuvant therapy with the case of a 25-year-old patient with an advanced ACC of the left fossa pterygopalatina.
  • Further we discuss alternative therapeutic options like neutron irradiation, chemotherapy or targeted therapy.
  • Following the advice from literature, we performed an eye saving tumor resection by a left transmaxilloethmoidale sphenoidectomy via combined trans- und extranasal approach.
  • RESULTS: With the described therapeutic strategy we reached an optimal local tumor control with unlimited visus and without functional and cosmetic restrictions up to now.
  • Periodic staging did not show any local tumor progress or metastatic spread hitherto.
  • CONCLUSION: Organ preserving surgery and adjuvant radiochemotherapy even in combination with taxol and carboplatin seems to be a sufficient therapeutic option in treating advanced sinunasal ACC, and might not have any prognostic disadvantages to radical surgery.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Neoplasm, Residual / surgery. Paranasal Sinus Neoplasms / surgery. Pterygopalatine Fossa / surgery. Skull Neoplasms / surgery. Sphenoid Sinus / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Chemotherapy, Adjuvant. Combined Modality Therapy. Endoscopy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neoplasm Staging. Orbit / pathology. Orbit / surgery. Paclitaxel / administration & dosage. Radiotherapy, Adjuvant. Sphenoid Bone / pathology. Sphenoid Bone / surgery. Surgery, Computer-Assisted. Tomography, X-Ray Computed

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 19813159.001).
  • [ISSN] 1438-8685
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
  • [Number-of-references] 51
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31. Cecchetto G, Carretto E, Bisogno G, Dall'Igna P, Ferrari A, Scarzello G, Donfrancesco A, Alaggio R, Indolfi P, Carli M: Complete second look operation and radiotherapy in locally advanced non-alveolar rhabdomyosarcoma in children: A report from the AIEOP soft tissue sarcoma committee. Pediatr Blood Cancer; 2008 Nov;51(5):593-7
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  • [Title] Complete second look operation and radiotherapy in locally advanced non-alveolar rhabdomyosarcoma in children: A report from the AIEOP soft tissue sarcoma committee.
  • PROCEDURE: We analyzed data from 39 patients (age: 0.5-194 months, median 52) who were enrolled between 1988 and 2005 in 2 consecutive Italian Studies, RMS 88 and RMS 96.
  • All achieved a complete resection of the residual tumor after neoadjuvant chemotherapy; 27 did not receive any other local treatment: pelvic 8, extremities 6, head-neck-non-parameningeal 5, orbit 1, genito-urinary-bladder-prostate 3, trunk 2, abdomen 1, vagina 1; 12 were given RT (32-45 Gy), 5 before and 7 after the operation: genito-urinary-bladder-prostate 3, pelvic 3, abdominal 1, extremities 1, head-neck-parameningeal 1, head-neck-non-parameningeal 1, vagina 1, orbit 1.
  • All received postoperative chemotherapy.
  • With RT: 10/12 patients are in first complete remission; 2/12 had a metastatic relapse (1 also local relapse), and both of them died of disease.
  • Without RT: 16/27 maintained the first complete remission, however 1/16 died due to a second tumor; 8 suffered from local relapse (4 pelvic, 1 orbit, 1 vagina, 1 head-neck-non-parameningeal, 1 abdomen) and 3 of them died, 3 showed a metastatic recurrence (2 extremities, 1 pelvic) and 1 died.
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Child. Child, Preschool. Clinical Trials as Topic. Combined Modality Therapy. Female. Humans. Infant. Kaplan-Meier Estimate. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / therapy. Radiotherapy, Adjuvant. Sarcoma

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18668515.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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32. Hallacq P, Labrousse F, Roullet B, Orsel S, Bessede JP, Moreau JJ: [Adenoid cystic carcinomas invading the skull base. Apropos of 4 cases and review of the literature]. Neurochirurgie; 2001 Dec;47(6):542-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Carcinomes adénoïdes kystiques envahissant la base du crâne. A propos de 4 observations et revue de la littérature.
  • Neurosurgical decision making is not well defined regarding the extent of intracranial tumor component removal, as neurosurgical expertise is limited for this peculiar type of tumors.
  • One patient with advanced metastatic disease was submitted to chemotherapy.
  • Three patients died from local tumor progression and distant metastases within three years after the intracranial tumor extension has been diagnosed.
  • The patient with an ethmoid tumor is still alive seven years after surgery without any evidence of local tumor progression nor distant metastases.
  • Surgery remains the gold standard treatment for adenoid cystic carcinomas invading the skull base.
  • However, in our opinion a large tumor removal, without or with bone osteotomies, but without sacrifice of cranial nerves, cavernous sinus, internal carotid artery, and of the orbit allows patient survival with an acceptable comfort and absence of psychological distress due to disfigurating surgery nor surgically induced neurological functional deficit.
  • The place of chemotherapy has, yet, to be determined.
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Radiotherapy, Adjuvant

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  • (PMID = 11915613.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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33. Sella A, Konichezky M, Flex D, Sulkes A, Baniel J: Low PSA metastatic androgen- independent prostate cancer. Eur Urol; 2000 Sep;38(3):250-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low PSA metastatic androgen- independent prostate cancer.
  • OBJECTIVES: To describe the clinical parameters of low PSA, progressive metastatic androgen-independent prostate cancer.
  • Patients received cisplatin-based therapy.
  • Specimens from the primary tumor were reviewed and neuroendocrine differentiation was determined with chromogranin-A and neuron-specific enolase immunocytochemical staining.
  • Metastases involved bone in 11 patients (61.1%) - 5 (27.7%) blastic, 2 (11.1%) lytic, and 4 (22.2%) combined - liver in 10 patients (55.5%), lymph nodes in 8 (44.4%), and lung in 6 (33.3%); solitary sites as orbit, skin and spleen were noted as well.
  • Of the 12 patients who consented to chemotherapy, 8 (66.6%) achieved an objective response (95% CI, 34.
  • CONCLUSIONS: Progressive androgen-independent prostate cancer with low serum PSA is characterized by visceral metastases, high proportion of lytic bone disease, sensitivity to cisplatin-based chemotherapy, and histological features of small cell or poorly differentiated prostate cancer.
  • In this subgroup of patients, selection of the therapeutic approach can be based on clinical parameters.
  • The rise of the serum markers may aid in the diagnosis and follow-up of these patients.
  • [MeSH-minor] Androgens. Humans. Male. Neoplasm Metastasis. Neoplasm Staging. Prospective Studies






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