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1. Pagliaro LC, Williams DL, Daliani D, Williams MB, Osai W, Kincaid M, Wen S, Thall PF, Pettaway CA: Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol; 2010 Aug 20;28(24):3851-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study.
  • PURPOSE: Men with penile squamous cell carcinoma and regional lymph node involvement have a low probability of survival with lymphadenectomy alone.
  • A multimodal approach to treatment is desirable for such patients.
  • We performed a phase II study of neoadjuvant chemotherapy with the objective of determining the response rate, time to progression (TTP), and overall survival (OS) among patients with bulky adenopathy.
  • PATIENTS AND METHODS: Eligible patients had stage N2 or N3 (stage III or stage IV) penile cancer without distant metastases.
  • Neoadjuvant treatment (four courses every 3-4 weeks) consisted of paclitaxel 175 mg/m(2) administered over 3 hours on day 1; ifosfamide 1,200 mg/m(2) on days 1 to 3; and cisplatin 25 mg/m(2) on days 1 to 3.
  • RESULTS: Thirty men received chemotherapy of whom 15 (50.0%) had an objective response and 22 (73.3%) subsequently underwent surgery.
  • Improved TTP and OS were significantly associated with a response to chemotherapy (P < .001 and P = .001, respectively), absence of bilateral residual tumor (P = .002 and P = .017, respectively), and absence of extranodal extension (P = .001 and P = .004, respectively) or skin involvement (P = .009 and P = .012, respectively).
  • CONCLUSION: The neoadjuvant regimen of paclitaxel, ifosfamide, and cisplatin induced clinically meaningful responses in patients with bulky regional lymph node metastases from penile cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / secondary. Lymph Node Excision. Neoadjuvant Therapy / methods. Penile Neoplasms / drug therapy. Penile Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Disease-Free Survival. Drug Administration Schedule. Humans. Ifosfamide / administration & dosage. Kaplan-Meier Estimate. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Predictive Value of Tests. Prospective Studies. Radiotherapy, Adjuvant. Risk Factors. Treatment Outcome

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  • (PMID = 20625118.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / P50 CA140388; United States / NCI NIH HHS / CA / CA016672
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
  • [Other-IDs] NLM/ PMC2940402
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2. Küronya Z, Bodrogi I, Lövey J, Plótár V, Manninger S, Pápai Z: [Metachronous metastasis from rectal adenocarcinoma to the penis--case report]. Magy Onkol; 2009 Sep;53(3):263-6
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  • [Title] [Metachronous metastasis from rectal adenocarcinoma to the penis--case report].
  • Despite of its rich vascularization and extensive circulatory communication with neighboring organs, penile metastases are rare.
  • Even more infrequent is a penile metastasis of rectum tumors.
  • Since the first report of rectal carcinoma with metastasis to the penis (Ehbert 1870), approximately 50 cases have been reported, most of them from the USA, the remaining from Western Europe, the Middle East and Japan.
  • The first Hungarian case is reported now of penile metastasis of a rectal carcinoma.
  • The case of a 65-year-old man is presented: isolated penile metastasis discovered 4.5 years after the primary rectal cancer resection.
  • IHC tissue diagnosis and detailed clinical investigations confirmed metastatic rectal adenocarcinoma.
  • As our patient refused penectomy and KRAS mutation was proven, FOLFIRI chemotherapy was initiated without cetuximab.
  • The size and the number of penile metastases have not shown significant changes.
  • According to the literature the average survival of patients with penile metastases treated with radiochemotherapy is 8 months.
  • [MeSH-major] Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasms, Second Primary / diagnosis. Palliative Care / methods. Penile Neoplasms / secondary. Rectal Neoplasms / pathology
  • [MeSH-minor] Aged. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cetuximab. Chemotherapy, Adjuvant. Diagnosis, Differential. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / drug therapy. Organoplatinum Compounds / administration & dosage. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 19793691.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; PQX0D8J21J / Cetuximab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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3. Hakenberg OW, Nippgen JB, Froehner M, Zastrow S, Wirth MP: Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma. BJU Int; 2006 Dec;98(6):1225-7
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  • [Title] Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma.
  • OBJECTIVE: To retrospectively evaluate the efficacy and toxicity of chemotherapy with cisplatinum, methotrexate and bleomycin (CMB) in the adjuvant and palliative setting, and its effect on survival in patients with locally advanced or metastatic penile carcinoma, which carries a very poor prognosis.
  • PATIENTS AND METHODS: Thirteen patients (mean age 54 years) with radically resected local and nodal disease (eight), metastatic disease (two) or metastatic recurrence (three) had chemotherapy with CMB between February 1996 and July 2003.
  • In all, 45 treatment courses were given, with a mean (range) of 3.5 (2-6) courses per patient.
  • RESULTS: Three of the eight patients with adjuvant treatment showed no evidence of disease after a mean (range) of 54 (41-76) months, while four in this group died from disease progression after a mean of 11 (5-20) months, and one died from treatment-related toxicity.
  • All five patients with metastatic disease died from disease progression after three had shown temporary signs of regression.
  • CONCLUSIONS: Chemotherapy with CMB had little effect on metastatic penile cancer and responses were transient.
  • However, patients with minimal disease after radical local and lymphatic resection seemed to benefit from adjuvant therapy, but the toxicity was high and carried a risk of death.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Penile Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Disease Progression. Humans. Male. Methotrexate / administration & dosage. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Treatment Outcome

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  • (PMID = 17125480.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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4. Pettaway CA, Pagliaro L, Theodore C, Haas G: Treatment of visceral, unresectable, or bulky/unresectable regional metastases of penile cancer. Urology; 2010 Aug;76(2 Suppl 1):S58-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of visceral, unresectable, or bulky/unresectable regional metastases of penile cancer.
  • OBJECTIVES: To review the treatment strategies among patients with Stage IV penile cancer to describe potentially curative or palliative therapy.
  • METHODS: The International Consultation on Urologic Disease for Penile Cancer subcommittee on the treatment of Stage IV penile cancer reviewed reports related to the topics of advanced penile cancer and metastatic penile cancer alone and combined with chemotherapy, radiotherapy, and inguinal lymphadenectomy.
  • Treatment recommendations were made by consensus, with the appropriate grades determined from the level of evidence.
  • RESULTS: The incidence of Stage IV disease using the current or modified TNM or Jackson descriptions was 0%-14%.
  • The role of radiotherapy for advanced penile cancer has been largely palliative.
  • Data have suggested that surgical consolidation among patients exhibiting an objective response to chemotherapy could be associated with durable survival.
  • CONCLUSIONS: Treatment with a cisplatin-containing regimen in Stage IV penile cancer should be considered and might facilitate curative resection.
  • The use of bleomycin was associated with a high level of toxicity and should be discouraged as first-line therapy.
  • Surgical consolidation to achieve disease-free status or palliation should be considered in fit patients with an objective response to systemic chemotherapy.
  • [MeSH-major] Pelvic Neoplasms / secondary. Pelvic Neoplasms / therapy. Penile Neoplasms / pathology. Penile Neoplasms / therapy
  • [MeSH-minor] Algorithms. Combined Modality Therapy. Humans. Male. Neoplasm Staging

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20691886.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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5. Trabulsi EJ, Hoffman-Censits J: Chemotherapy for penile and urethral carcinoma. Urol Clin North Am; 2010 Aug;37(3):467-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy for penile and urethral carcinoma.
  • Although surgery is the mainstay of curative treatment of carcinomas of the penis and urethra, there is a role for systemic cytotoxic chemotherapy for locally advanced, unresectable, or metastatic tumors.
  • Although this field is limited by a paucity of clinical trials or prospective data, the available single institutional retrospective reviews indicate that multi-agent cisplatin-based combination chemotherapy regimens have significant activity and may allow curative surgery for patients with otherwise unresectable tumors.
  • This article reviews the available literature on chemotherapy for carcinoma of the penis and urethra in the neoadjuvant, adjuvant, and metastatic setting.
  • [MeSH-major] Penile Neoplasms / drug therapy. Urethral Neoplasms / drug therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Chemotherapy, Adjuvant. Humans. Male. Neoadjuvant Therapy. Taxoids / therapeutic use

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20674701.001).
  • [ISSN] 1558-318X
  • [Journal-full-title] The Urologic clinics of North America
  • [ISO-abbreviation] Urol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Taxoids
  • [Number-of-references] 34
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6. Pagliaro LC, Crook J: Multimodality therapy in penile cancer: when and which treatments? World J Urol; 2009 Apr;27(2):221-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multimodality therapy in penile cancer: when and which treatments?
  • OBJECTIVES: Metastatic penile cancer typically comes to attention while the clinical extent of disease is limited to the inguinal or pelvic lymph nodes.
  • To determine the optimal use of multimodality treatment in locally advanced penile cancer, we conducted a literature review.
  • RESULTS: There is an emerging strategy of preoperative (neoadjuvant) combination chemotherapy to improve the progression-free survival of penile cancer patients with bulky regional lymph node metastases.
  • CONCLUSIONS: In patients with lymph node metastases, the benefit of ilioinguinal lymphadenectomy may be extended by the addition of neoadjuvant chemotherapy.
  • Postoperative radiotherapy can be offered depending on the amount of residual disease after chemotherapy.
  • Chemo-radiotherapy has been successful in squamous cell cancers from other sites (vulva and anal canal) and may be considered for unresectable penile cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Penile Neoplasms / therapy
  • [MeSH-minor] Algorithms. Combined Modality Therapy. Humans. Male

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  • (PMID = 18682961.001).
  • [ISSN] 1433-8726
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
  • [Other-IDs] NLM/ NIHMS624802; NLM/ PMC4164341
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7. Smith Y, Hadway P, Ahmed S, Perry MJ, Corbishley CM, Watkin NA: Penile-preserving surgery for male distal urethral carcinoma. BJU Int; 2007 Jul;100(1):82-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile-preserving surgery for male distal urethral carcinoma.
  • OBJECTIVE: To evaluate medium-term outcome data from patients with distal urethral cancers treated with penile-preserving surgery.
  • PATIENTS AND METHODS: We analysed prospectively 18 consecutive men referred for the management of urethral carcinoma.
  • Tumours were staged according to the Tumour-Node-Metastasis classification and the patients offered penile-preserving surgery when tumours were limited to the glanular or penile urethra.
  • RESULTS: All 18 patients were suitable for penile-preserving surgery; the procedures were: three hypospadias formation with or without topical chemotherapy; four buccal mucosa urethroplasty; three glansectomy and reconstruction; six glansectomy, distal corporectomy, reconstruction and hypospadias formation; two urethrectomy with or with no excision of adjacent tunica albuginea.
  • There were no local recurrences; four patients with regional nodal disease progressed and of these, two died from metastatic disease, and one died from an unrelated condition.
  • CONCLUSION: Medium-term data show that penile-preserving surgery is a feasible treatment for men with distal urethral carcinoma, providing excellent local control without prejudicing survival; a longer follow-up is needed.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Penis / surgery. Urethral Neoplasms / surgery. Urologic Surgical Procedures, Male / standards
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Feasibility Studies. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies. Treatment Outcome

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  • (PMID = 17488307.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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8. Kawahara T, Manabe Y, Asazuma A, Aoyama T, Hashimura T: [Hormone refractory prostate carcinoma metastasizes to the penis: a case report]. Hinyokika Kiyo; 2009 Oct;55(10):627-9
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  • [Title] [Hormone refractory prostate carcinoma metastasizes to the penis: a case report].
  • A 76-year-old man presented with urinary retention and penile discomfort.
  • At 67-years-old, he was diagnosed with stage D2 prostate cancer and then, was treated with hormone therapy.
  • Several nodules were observed on the glans, and histological examination of the penile tumor biopsy showed metastatic adenocarcinoma of the prostate.
  • [MeSH-major] Adenocarcinoma / pathology. Penile Neoplasms / secondary. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Androgen Antagonists / therapeutic use. Drug Resistance, Neoplasm. Humans. Male

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  • (PMID = 19938335.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Androgen Antagonists
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9. Bermejo C, Busby JE, Spiess PE, Heller L, Pagliaro LC, Pettaway CA: Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma. J Urol; 2007 Apr;177(4):1335-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma.
  • PURPOSE: Combination chemotherapy for advanced penile cancer can produce partial response rates of up to 64%.
  • Complete responses are rare, suggesting a need for adjunct therapies to facilitate cure.
  • We evaluated patients with metastases who underwent surgical consolidation after responding to chemotherapy.
  • MATERIALS AND METHODS: We reviewed the records of 59 patients with advanced penile carcinoma treated from 1985 to 2000 and identified 10 treated with surgical consolidation after demonstrating a stable, partial or complete response to chemotherapy.
  • RESULTS: After chemotherapy 4 patients had a complete response, 1 had a partial response and 5 had stable disease.
  • All 3 patients received ifosfamide, paclitaxel and cisplatin chemotherapy.
  • Seven patients had 3 or fewer metastatic lymph nodes following surgery, of whom 4 showed no disease and 3 died.
  • All 3 patients with greater than 3 metastatic lymph nodes died.
  • CONCLUSIONS: Select patients with metastatic penile cancer that shows disease stabilization or a response to chemotherapy should be considered for surgical consolidation to extend survival.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / surgery. Penile Neoplasms / drug therapy. Penile Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Humans. Male. Middle Aged. Neoadjuvant Therapy

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  • (PMID = 17382727.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Ferreira U, Reis LO, Ikari LY, da Silva W Jr, Matheus WE, Denardi F, Stopiglia RM, Menezes FH: Extra-anatomical transobturator bypass graft for femoral artery involvement by metastatic carcinoma of the penis: report of five patients. World J Urol; 2008 Oct;26(5):487-91
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  • [Title] Extra-anatomical transobturator bypass graft for femoral artery involvement by metastatic carcinoma of the penis: report of five patients.
  • OBJECTIVES: Squamous cell carcinoma (SCC) of the penis with inguinal lymph node involvement aggravates prognosis and can cause femoral artery bleeding, hemorrhagic shock and even death.
  • The objective of this study is to describe the use of extra-anatomical transobturator bypass graft for femoral artery involvement by metastatic carcinoma of the penis.
  • RESULTS: After extra-anatomical transobturator bypass, all patients presented distal pulses.
  • The mean time of surgery was 6 h.
  • Two patients chose not to undergo inguinal resection, opting for palliative chemotherapy after the vascular procedure.
  • CONCLUSIONS: The use of the transobturator bypass can benefit patients presenting with penile SCC and inguinal lymph nodes metastasis involving the femoral vessels, allowing resection of extensive tumor lesions, as well as avoidance of local complications.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Femoral Artery / surgery. Penile Neoplasms / pathology. Vascular Neoplasms / secondary. Vascular Neoplasms / surgery

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  • (PMID = 18581120.001).
  • [ISSN] 0724-4983
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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11. Protzel C, Klebingat HJ, Hakenberg OW: [Treatment of advanced penile cancer. Do we need new methods for chemotherapy?]. Urologe A; 2008 Sep;47(9):1229-32
Hazardous Substances Data Bank. METHOTREXATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of advanced penile cancer. Do we need new methods for chemotherapy?].
  • [Transliterated title] Zur Therapie des fortgeschrittenen Peniskarzinoms. Brauchen wir neue Wege in der Chemotherapie?
  • Penile cancer is a squamous epithelial neoplasia with a very high mortality in advanced stages.
  • Only few series with small patient numbers have addressed the systemic treatment of advanced penile carcinoma.
  • Due to the relative paucity of data, recommendations and guidelines on the treatment of metastatic penile carcinoma are vague.
  • New approaches and large-scale studies that will allow better definition of adequate and more effective treatment options are needed.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Penile Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Bleomycin / administration & dosage. Bleomycin / adverse effects. Carboplatin / administration & dosage. Carboplatin / adverse effects. Cyclophosphamide / administration & dosage. Cyclophosphamide / adverse effects. Disease Progression. Humans. Male. Methotrexate / administration & dosage. Methotrexate / adverse effects. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Paclitaxel / administration & dosage. Paclitaxel / adverse effects. Palliative Care

  • Hazardous Substances Data Bank. BLEOMYCIN .
  • Hazardous Substances Data Bank. TAXOL .
  • Hazardous Substances Data Bank. CARBOPLATIN .
  • Hazardous Substances Data Bank. CYCLOPHOSPHAMIDE .
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  • (PMID = 18688593.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel; YL5FZ2Y5U1 / Methotrexate; CMB protocol
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12. Otto T, Suhr J, Krege S, Rübben H: [Therapy of advanced penis carcinoma]. Urologe A; 2003 Nov;42(11):1466-9
Hazardous Substances Data Bank. METHOTREXATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Therapy of advanced penis carcinoma].
  • [Transliterated title] Die Therapie des fortgeschrittenen Peniskarzinoms.
  • Skin infiltration and locoregional lymph node extension in metastatic penile cancer leads to destruction in the inguinal and perineal region.
  • The obligatorily superinfected defects require tension-free and extended coverage with immediate myocutaneous flaps after surgical resection.
  • Data concerning a prospective study for neoadjuvant chemotherapy with CMB followed by surgical tumor resection with immediate myocutaneous flap reconstruction are presented.
  • In 15 patients (median age: 69.7 years) suffering from squamous cell carcinoma of the penis (Tx, N3, M1 cutis), a surgical excision of the tumor was performed after neoadjuvant chemotherapy (median:2.4 cycles) and antibiotic pretreatment.
  • An extended (up to 45x30 cm) tension-free coverage of groin defects was performed in two patients with a unilateral M. tensor fasciae latae flap (TFL) and in eight patients with a bilateral TFL.
  • One patient received a M. gluteus maximus flap (GMFL) on both sides, three patients were treated with a combination of M. rectus abdominis flap (RFL) and TFL, and one patient received a combination of two TFL, one GMFL as well as one RFL.
  • Of 31 myocutaneous pedicle flaps, 2 developed distant necrosis of the flap, in which one GMFL and one TFL were affected.
  • The covering of groin defects by the use of myocutaneous flaps, such as the M. tensor fasciae latae, M. rectus abdominis, and M. gluteus maximus flap, is a method of first choice in the primary treatment of even bacterially contaminated wounds or after radiation therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Neoadjuvant Therapy. Penile Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antibiotic Prophylaxis. Bleomycin / administration & dosage. Bleomycin / adverse effects. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Graft Survival / drug effects. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Methotrexate / administration & dosage. Methotrexate / adverse effects. Microsurgery. Neoplasm Invasiveness. Neoplasm Staging. Skin / pathology. Superinfection / prevention & control. Surgical Flaps / blood supply. Surgical Wound Infection / prevention & control. Suture Techniques. Treatment Outcome. Wound Healing / drug effects

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  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
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  • [Cites] J Urol. 1982 Sep;128(3):599-601 [7120574.001]
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  • (PMID = 14624345.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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13. Power DG, Galvin DJ, Cuffe S, McVey GP, Mulholland PJ, Farrelly C, Delaney DW, O'Byrne KJ: Cisplatin and gemcitabine in the management of metastatic penile cancer. Urol Oncol; 2009 Mar-Apr;27(2):187-90
Hazardous Substances Data Bank. METHOTREXATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cisplatin and gemcitabine in the management of metastatic penile cancer.
  • Penile cancer is rare and receives little public attention.
  • There are few treatment options for advanced disease.
  • However the treatment-related mortality is 11% and hence this combination has not been adapted as a standard of care.
  • We report two cases of advanced penile cancer where a sustained palliative response was observed with combination chemotherapy using cisplatin and gemcitabine.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Deoxycytidine / analogs & derivatives. Penile Neoplasms / drug therapy
  • [MeSH-minor] Aged. Biopsy. Bleomycin / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Humans. Male. Methotrexate / administration & dosage. Middle Aged. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • Hazardous Substances Data Bank. BLEOMYCIN .
  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
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  • (PMID = 18367122.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 11056-06-7 / Bleomycin; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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14. Khan MA, Tao W, Mathews P, Potluri BS: Penile metastasis arising from transitional cell carcinoma of the urinary bladder. Urol Int; 2001;66(3):162-3
MedlinePlus Health Information. consumer health - Bladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile metastasis arising from transitional cell carcinoma of the urinary bladder.
  • Metastatic spread of transitional cell carcinoma of the bladder to the penis is very rare.
  • We present 1 such case in a 63-year-old man that was treated by total penectomy and adjuvant systemic chemotherapy.
  • [MeSH-major] Carcinoma, Transitional Cell / secondary. Penile Neoplasms / secondary. Urinary Bladder Neoplasms / pathology

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  • [Copyright] Copyright 2001 S. Karger AG, Basel
  • (PMID = 11316981.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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15. Sheen MC, Sheu HM, Huang CH, Wang YW, Chai CY, Wu CF: Penile verrucous carcinoma successfully treated by intra-aortic infusion with methotrexate. Urology; 2003 Jun;61(6):1216-20
Hazardous Substances Data Bank. METHOTREXATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile verrucous carcinoma successfully treated by intra-aortic infusion with methotrexate.
  • OBJECTIVES: Penile verrucous carcinoma is characterized by aggressive local growth and a low metastatic potential.
  • Lower abdominal aortic infusion chemotherapy has the main advantage of delivering a very high concentration of an anticancer drug to the whole pelvic area, including the penis, and is especially suitable to treat penile verrucous carcinoma.
  • METHODS: From 1991 to 2000, 4 cases of penile verrucous carcinoma were treated by continuous intra-aortic infusion with methotrexate (50 mg) every 24 hours, for an average of 10 days.
  • RESULTS: After treatment, 3 patients achieved complete remission.
  • They were living disease free 10 years, 10 months, 6 years, 9 months, and 1 year, 8 months after therapy.
  • CONCLUSIONS: Intra-aortic infusion chemotherapy is a simple and effective method for penile verrucous carcinoma with the unique advantage of preserving cosmetic and functional integrity.
  • It may be considered an effective alternative treatment for penile verrucous carcinoma.
  • [MeSH-major] Aorta, Abdominal / metabolism. Carcinoma, Verrucous / drug therapy. Infusions, Intra-Arterial / methods. Methotrexate / administration & dosage. Methotrexate / therapeutic use. Penile Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Antimetabolites, Antineoplastic / administration & dosage. Antimetabolites, Antineoplastic / therapeutic use. Disease-Free Survival. Exanthema / etiology. Humans. Male. Middle Aged. Pruritus / etiology. Remission Induction / methods. Taiwan

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  • (PMID = 12809900.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; YL5FZ2Y5U1 / Methotrexate
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16. Mosconi AM, Roila F, Gatta G, Theodore C: Cancer of the penis. Crit Rev Oncol Hematol; 2005 Feb;53(2):165-77

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer of the penis.
  • Cancer of the penis is rare in Europe, accounting for less than 0.5% of all cancers.
  • More than 95% of penile carcinomas are squamous cell carcinomas.
  • Early disease (stage I-II) is curable in most patients, who can be treated by conventional penile amputation or, in selected cases, by organ preserving techniques, including Moh's micrographic surgery, laser ablation or radiation therapy (external-beam, brachytherapy).
  • For more advanced primary tumours, penile amputation is required.
  • Survival of patients with penile cancer is strongly related to the presence and extent of nodal metastases.
  • Bilateral inguinal lymphadenectomy is recommended for palpable lymph nodes that persist 3 or more weeks after removal of the primary tumour and a course of antibiotic therapy.
  • The role of chemotherapy, as adjuvant and neoadjuvant or primary treatment in metastatic disease, needs to be further explored in prospective clinical trials.
  • [MeSH-major] Carcinoma, Squamous Cell. Penile Neoplasms

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  • (PMID = 15661566.001).
  • [ISSN] 1040-8428
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 98
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17. Syed S, Eng TY, Thomas CR, Thompson IM, Weiss GR: Current issues in the management of advanced squamous cell carcinoma of the penis. Urol Oncol; 2003 Nov-Dec;21(6):431-8
Genetic Alliance. consumer health - Carcinoma, Squamous Cell.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current issues in the management of advanced squamous cell carcinoma of the penis.
  • Effective treatment of penile carcinoma incorporates three modalities: surgery, radiation and chemotherapy.
  • In certain patients radiation therapy may be utilized to eradicate the tumor and allow organ preservation.
  • For patients with locally advanced disease, multi-modality approaches incorporating adjuvant or neoadjuvant chemotherapy and radiation therapy need to be studied.
  • Finally, in the setting of metastatic disease, less toxic and more effective combination chemotherapy are sought.
  • Novel targeted therapies that have been successful in squamous cell carcinoma at other sites must also be studied in this disease.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Penile Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Combined Modality Therapy. Humans. Male. Prognosis

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  • (PMID = 14693269.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 86
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18. Misra S, Chaturvedi A, Misra NC: Penile carcinoma: a challenge for the developing world. Lancet Oncol; 2004 Apr;5(4):240-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile carcinoma: a challenge for the developing world.
  • Although rare in developed countries, carcinoma of the penis is an important problem in the developing world.
  • Poor penile hygiene and phimosis are strong risk factors for development of penile carcinoma.
  • Early disease can be treated by conventional resection of the penis, or in selected patients by organ preserving techniques including Mohs micrographic surgery, and laser and radiation therapy.
  • Elective or therapeutic lymph-node dissection is recommended for inguinal metastatic disease, and depending on the disease status, unilateral or bilateral inguinal or ilioinguinal lymphadenectomy might be needed.
  • The role of chemotherapy, as adjuvant or primary treatment in metastatic disease, needs to be defined in prospective clinical trials, which can be done in developing countries.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Developing Countries. Penile Neoplasms / radiotherapy. Penile Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. Combined Modality Therapy. Humans. Hygiene. Incidence. Lymph Node Excision. Male. Neoplasm Staging. Phimosis / complications. Risk Factors

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  • (PMID = 15050955.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 76
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19. Di Lorenzo G, Cartenì G, Autorino R, Gonnella A, Perdonà S, Ferro M, Longo N, Rescigno P, Doria F, Faiella A, Altieri V, Palmieri G, Imbimbo C, Mirone V, De Placido S: Activity and toxicity of paclitaxel in pretreated metastatic penile cancer patients. Anticancer Drugs; 2009 Apr;20(4):277-80
Hazardous Substances Data Bank. TAXOL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity and toxicity of paclitaxel in pretreated metastatic penile cancer patients.
  • The objective of this study was to evaluate the use of paclitaxel in patients with advanced squamous cell penile cancer previously treated with neoadjuvant cisplatin-based chemotherapy.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Paclitaxel / therapeutic use. Penile Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Cisplatin / therapeutic use. Disease-Free Survival. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neutropenia / chemically induced. Stomatitis / chemically induced. Survival Rate. Treatment Outcome

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  • (PMID = 19262371.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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20. Matuszewska K, Matuszewski M, Kowalczyk A, Jassem J: Penile metastases from urogenital primaries. Neoplasma; 2002;49(5):346-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile metastases from urogenital primaries.
  • Metastatic tumors of the penis are rare.
  • This entity is usually accompanied by distressing symptoms like dysuria, pain, induration, swelling of the penis and priapism, making immediate intervention necessary.
  • Different methods of treatment are used to achieve the palliative effect: local surgical excision, penis amputation, radiotherapy or chemotherapy.
  • [MeSH-major] Penile Neoplasms / secondary. Penile Neoplasms / therapy. Urogenital Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma / diagnosis. Carcinoma / secondary. Carcinoma / therapy. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis

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  • (PMID = 12458336.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovakia
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21. Zheng FF, Zhang ZY, Dai YP, Liang YY, Deng CH, Tao Y: Metastasis to the penis in a patient with adenocarcinoma of lung, case report and literature review. Med Oncol; 2009;26(2):228-32
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis to the penis in a patient with adenocarcinoma of lung, case report and literature review.
  • Metastasis of lung cancer to the penis is very rare; it causes various clinical symptoms seriously affecting the quality of life.
  • Here, we report a case of penile metastasis secondary to pulmonary carcinoma along with a review of the literature.
  • One case of penile metastasis secondary to pulmonary carcinoma was detected in a 51-year-old patient who was admitted to the First Affiliated Hospital of Sun Yat-Sen University with persistent cough along with swelling of the perineum and penis.
  • The clinical features, diagnosis, and treatment of this disease along with a relevant literature are reviewed and discussed.
  • CT scan revealed lung mass, and a glans penis ulcer and enlargement of inguinal lymph nodes was discovered upon physical examination.
  • CT-guided percutaneous puncture of the lung mass revealed adenocarcinoma of lung, and biopsies of the glans penis ulcer and inguinal lymph nodes confirmed metastatic adenocarcinoma.
  • The patients received chemotherapy and died of acute pulmonary embolism in less than 2 months.
  • Metastasis of lung cancer to the penis is extremely rare.
  • It presents an advanced form of lung cancer, and thus survival is extremely short.
  • Although treatment of penile metastasis is almost always palliative, early recognition may enhance survival for these patients.
  • [MeSH-major] Adenocarcinoma / pathology. Lung Neoplasms / pathology. Penile Neoplasms / secondary

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  • (PMID = 18975150.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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22. Sofikerim M, Gülmez I, Tokat F, Er O, Gülmez I: Epidermoid carcinoma of the lung with isolated penile metastasis. Can J Urol; 2007 Aug;14(4):3643-5
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermoid carcinoma of the lung with isolated penile metastasis.
  • We report a case of epidermoid-cell carcinoma of the lung that developed a metastatic lesion in the penis.
  • He had a left pneumectomy and was diagnosed with epidermoid carcinoma of the lung at stage IIB (T2N1M0).
  • He was started on an adjuvant chemotherapy protocol consisting of cisplatin and paclitaxel.
  • He was admitted to our urology clinic with obstructive symptoms during urination and pain during penile erection.
  • Physical examination revealed a firm, 3 cm x 2 cm palpable mass on the radix of his penis.
  • A fine-needle aspiration biopsy of the penile mass revealed epidermoid carcinoma that was consistent with lung cancer.
  • The patient was considered to have penile metastasis from epidermoid carcinoma of the lung.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Lung Neoplasms / pathology. Penile Neoplasms / secondary

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  • (PMID = 17784986.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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23. Mobilio G, Ficarra V: Genital treatment of penile carcinoma. Curr Opin Urol; 2001 May;11(3):299-304

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genital treatment of penile carcinoma.
  • Squamous penile carcinoma is an uncommon neoplastic disease with an incidence of one in 100 000 men per year in Western countries.
  • The role of penile-sparing treatment represents one of the three main issues in management of squamous carcinoma of the penis.
  • Most authors consider conservative therapy as an indicated alternative treatment to partial or total penectomy in small size, low stage and grade tumours.
  • At present, external or interstitial beam radiotherapy and lasertherapy represent the best available conservative therapeutic approaches.
  • The third point of discussion is represented by the use of chemotherapy in patients with metastatic disease.
  • In this stage of disease, polychemotherapy with cisplatin, methotrexate and bleomycin seems to be more effective.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Penile Neoplasms / therapy

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  • (PMID = 11371784.001).
  • [ISSN] 0963-0643
  • [Journal-full-title] Current opinion in urology
  • [ISO-abbreviation] Curr Opin Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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24. Skeel RT, Huang J, Manola J, Wilding G, Dreicer R, Walker P, Muggia F, Crawford ED, Dutcher JP, Loehrer PJ: A phase II study of 13-cis retinoic acid plus interferon alpha-2a in advanced stage penile carcinoma: an Eastern Cooperative Oncology Group study (E3893). Cancer Invest; 2003;21(1):41-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A phase II study of 13-cis retinoic acid plus interferon alpha-2a in advanced stage penile carcinoma: an Eastern Cooperative Oncology Group study (E3893).
  • PURPOSE: Combined biological therapy with 13-cis-retinoic acid (13-cRA) and interferon alpha-2a (IFN alpha-2a) was reported to be highly effective in squamous cell carcinoma of the cervix and skin.
  • Squamous cell carcinoma of the penis is rare in the United States, accounting for less than 1/2% of all male malignancies.
  • Because of the association of infection with human papillomavirus with both carcinomas of the cervix and penis and their shared squamous cell histology, we carried out a phase II study of 13-cRA and IFN alpha-2a in carcinoma of the penis.
  • MATERIALS AND METHODS: Eighteen ambulatory patients with surgically unresectable, recurrent, and/or metastatic squamous cell carcinoma of the penis were treated with IFN alpha-2a, 3MU/day administered subcutaneously and 13-cRA, 1 mg/kg orally daily for at least eight weeks, unless intolerable toxicity occurred.
  • RESULTS: One patient was ineligible; one patient withdrew prior to treatment.
  • Fourteen patients had progressive disease as their only treatment effect.
  • No unexpected treatment-related toxicities were found on study.
  • CONCLUSION: In contrast to its benefit in squamous cell carcinomas of the cervix and skin, the combination of 13-cRA and IFN alpha-2a has low efficacy in advanced carcinoma of the penis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Penile Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Anemia / chemically induced. Disease Progression. Fatigue / chemically induced. Fever / chemically induced. Humans. Hypertriglyceridemia / chemically induced. Interferon-alpha / administration & dosage. Interferon-alpha / adverse effects. Isotretinoin / administration & dosage. Isotretinoin / adverse effects. Life Tables. Male. Middle Aged. Recombinant Proteins. Survival Analysis. Treatment Failure

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  • (PMID = 12643008.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA14958; United States / NCI NIH HHS / CA / CA21115; United States / NCI NIH HHS / CA / CA23318; United States / NCI NIH HHS / CA / CA32102; United States / NCI NIH HHS / CA / CA42777; United States / NCI NIH HHS / CA / CA49883; United States / NCI NIH HHS / CA / CA58882; United States / NCI NIH HHS / CA / CA66636; United States / NCI NIH HHS / CA / CACA21076
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon-alpha; 0 / Recombinant Proteins; 76543-88-9 / interferon alfa-2a; EH28UP18IF / Isotretinoin
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25. Marconnet L, Bouchot O, Culine S, Avances C, Rigaud J, membres du CCAFU-OGE: [Treatment of lymph nodes in epidermoid carcinoma of the penis: review of literature by the Committee of Cancerology of the French Association of Urology-External Genital Organs Group (CCAFU-OGE)]. Prog Urol; 2010 May;20(5):332-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of lymph nodes in epidermoid carcinoma of the penis: review of literature by the Committee of Cancerology of the French Association of Urology-External Genital Organs Group (CCAFU-OGE)].
  • [Transliterated title] Prise en charge ganglionnaire dans le carcinome épidermoïde du pénis: revue de la littérature par le comité de cancérologie de l'Association française d'urologie-groupe organes génitaux externes (CCAFU-OGE).
  • INTRODUCTION: Invasive lymph nodes are an independent factor of prognosis and essential for the survival of patients with cancer of the penis.
  • The aim of this article is to analyse published research results on the diagnosis and treatment of lymph nodes in cancer of the penis.
  • MATERIAL AND METHOD: Bibliographic research on Medline was carried out using the terms penile carcinoma, lymph node dissection, lymphadenectomy, survival, chemotherapy and radiotherapy.
  • RESULTS: The risk of lymph node metastasis depends on the stage of the primitive tumour, its histological grade, the presence of venous and lymphatic embolus and the presence of palpable lymph nodes (classification into risk groups by the European Association of Urology [EAU]).
  • Not only is surgery on inguinal lymph nodes the only reliable way of confirming an invasive metastatic lymph node, it also plays a therapeutic and prognostic role for patients who have a tumour of the penis which risks spreading to lymph nodes (intermediate or high risk according to EAU).
  • The type of dissection is in function with the clinical examination: a radical inguinal dissection is recommended in the case of palpated adenopathy and a modified inguinal dissection is recommended if there is no palpated adenopathy, this should be radicalised in the case of metastatic adenopathy on histological examination.
  • Neo-adjuvant or adjuvant chemotherapy would appear to play a interesting role when combined with surgery for certain patients without there being currently being precise consensus because of the lack of documented cases.
  • CONCLUSION: Lymph node dissection alone has a therapeutic role in patients who have reached metastasis of lymph nodes (stage pN1).
  • However, it remains insufficient for patients who have metastatic infiltration of more than 2 lymph nodes (stage > or =pN2).
  • Consequently, it would seem important to develop multimodal approaches in the treatment of these patients in order to increase the rate of response to treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lymph Node Excision. Penile Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. France. Humans. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Societies, Medical. Urology

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20471577.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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26. Cathomas R, Geldart TR, Iveson T, Singh N, Rowen D: An unusual differential diagnosis of penile warts: metastases from rectal carcinoma. Int J STD AIDS; 2006 Jul;17(7):491-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual differential diagnosis of penile warts: metastases from rectal carcinoma.
  • Patients with penile lesions, such as virally induced papillomata, frequently present to genitourinary medicine clinics and general practitioners.
  • Penile lesions may rarely have a more sinister aetiology and represent metastatic spread from solid tumours arising at distant sites.
  • Penile metastases arise most frequently from genitourinary cancers (prostate, bladder and kidney), but may also arise from tumours of the large bowel; other primary sites are extremely uncommon.
  • We report the case of a patient presenting with penile metastases from rectal carcinoma arising during third-line chemotherapy for metastatic disease.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Penis / pathology. Rectal Neoplasms / pathology. Warts / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Penile Diseases / diagnosis. Penile Diseases / pathology

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  • (PMID = 16820084.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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27. Siow WY, Cheng C: Penile cancer: current challenges. Can J Urol; 2005 Feb;12 Suppl 1:18-23; discussion 97-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile cancer: current challenges.
  • Penile cancer remains a formidable challenge in many developing countries because of its high incidence and the advanced disease stage at diagnosis.
  • For early penile cancer, surgery alone offers a high cure rate.
  • Penile sparing therapies are proposed as alternative treatment options for select patients with the added advantages of preservation of body image and improved quality of life.
  • For advanced, metastatic penile cancer, more effective and less toxic chemotherapy is needed.
  • [MeSH-major] Lymph Nodes / pathology. Neoplasm Invasiveness / pathology. Penile Neoplasms / pathology. Penile Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Developing Countries. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant. Risk Assessment. Singapore / epidemiology. Survival Analysis. Treatment Outcome. Urologic Surgical Procedures, Male / methods

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  • (PMID = 15780160.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 83
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