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Items 1 to 38 of about 38
1. Mizutani K, Seike K, Sugawara T, Masue T, Yokoi S, Ehara H, Takahashi Y, Ishihara S, Deguchi T: [Multiple metastases of the penile cancer: an experience of combination chemotherapy]. Hinyokika Kiyo; 2004 Mar;50(3):223-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiple metastases of the penile cancer: an experience of combination chemotherapy].
  • A 49-year-old man with penile cancer (cT3N1M0) was referred to our hospital.
  • The pathologic diagnosis was squamous cell carcinoma.
  • The patient underwent penectomy and bilateral inguinal lymphadenectomy without postoperative adjuvant therapy.
  • Six months later, we found multiple metastases of the penile cancer in the lungs.
  • The patient was then treated with combination chemotherapy of cisplatin, methotrexate, bleomycin.
  • However, the tumors were aggressive and did not respond to the therapy.
  • We discuss the use of combination chemotherapy in the case of advanced penile cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / secondary. Lymph Nodes / pathology. Neoplastic Cells, Circulating / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Bleomycin / administration & dosage. Bone Neoplasms / secondary. Cisplatin / administration & dosage. Drug Administration Schedule. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Male. Methotrexate / administration & dosage. Middle Aged. Penis / surgery

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  • (PMID = 15148780.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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2. Küronya Z, Bodrogi I, Lövey J, Plótár V, Manninger S, Pápai Z: [Metachronous metastasis from rectal adenocarcinoma to the penis--case report]. Magy Onkol; 2009 Sep;53(3):263-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metachronous metastasis from rectal adenocarcinoma to the penis--case report].
  • Despite of its rich vascularization and extensive circulatory communication with neighboring organs, penile metastases are rare.
  • Even more infrequent is a penile metastasis of rectum tumors.
  • Since the first report of rectal carcinoma with metastasis to the penis (Ehbert 1870), approximately 50 cases have been reported, most of them from the USA, the remaining from Western Europe, the Middle East and Japan.
  • The first Hungarian case is reported now of penile metastasis of a rectal carcinoma.
  • The case of a 65-year-old man is presented: isolated penile metastasis discovered 4.5 years after the primary rectal cancer resection.
  • IHC tissue diagnosis and detailed clinical investigations confirmed metastatic rectal adenocarcinoma.
  • As our patient refused penectomy and KRAS mutation was proven, FOLFIRI chemotherapy was initiated without cetuximab.
  • The size and the number of penile metastases have not shown significant changes.
  • According to the literature the average survival of patients with penile metastases treated with radiochemotherapy is 8 months.
  • [MeSH-major] Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasms, Second Primary / diagnosis. Palliative Care / methods. Penile Neoplasms / secondary. Rectal Neoplasms / pathology
  • [MeSH-minor] Aged. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cetuximab. Chemotherapy, Adjuvant. Diagnosis, Differential. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / drug therapy. Organoplatinum Compounds / administration & dosage. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 19793691.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; PQX0D8J21J / Cetuximab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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3. Yumura Y, Takase K, Suwa H, Ohta J, Ueki T, Kawai M, Fujikawa A, Yokomizo Y, Moriyama M: [Neoadjuvant and adjuvant chemotherapy with methotrexate, cisplatin and bleomycin for advanced penile cancer: a case report]. Hinyokika Kiyo; 2007 Nov;53(11):825-7
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  • [Title] [Neoadjuvant and adjuvant chemotherapy with methotrexate, cisplatin and bleomycin for advanced penile cancer: a case report].
  • A 58-year-old male consulted our hospital because of penile swelling and pain with bilateral inguinal lymphadenopathy.
  • Pathological examination of the penile tumor and right superficial inguinal lymph node biopsy demonstrated moderately differentiated squamous cell carcinoma with lymph node metastasis.
  • We diagnosed the tumor inoperable radically and adjuvant chemotherapy with methotrexate, cisplatin and bleomycin was administered, followed by partial penectomy and left superficial lymphadenectomy.
  • The surgical specimens showed few viable tumor cells.
  • This combination chemotherapy is suggested to be effective for the treatment of advanced penile cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / therapy. Neoadjuvant Therapy. Penile Neoplasms / therapy. Penis / surgery
  • [MeSH-minor] Bleomycin / administration & dosage. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Disease-Free Survival. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Methotrexate / administration & dosage. Middle Aged. Neoplasm Staging. Treatment Outcome. Urologic Surgical Procedures, Male

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  • (PMID = 18051811.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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4. Heidenreich A, Jakse G: [Neoadjuvant and adjuvant chemotherapy in patients with advanced penile cancer]. Urologe A; 2007 Oct;46(10):1395-6, 1398-9
Hazardous Substances Data Bank. METHOTREXATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neoadjuvant and adjuvant chemotherapy in patients with advanced penile cancer].
  • [Transliterated title] Neoadjuvante und adjuvante Chemotherapie bei Patienten mit fortgeschrittenem Peniskarzinom.
  • With an incidence of 0.1-0.9/100,000 men per year penile cancer is a rare cancer of the urogenital tract in Western Europe.
  • At the time of initial diagnosis up to 45% of the patients already demonstrate metastatic disease and need some type of systemic treatment.
  • It is the aim of this paper to review the current concepts of adjuvant and neoadjuvant chemotherapy for locally advanced penile cancer.
  • Although there are prospective randomized trials available indicating the optimal cytotoxic regime, cisplatin-based protocols or combination therapies with bleomycin, vincristine, and methotrexate appear to be the most effective options.
  • Finally, there are no data available with regard to the effect of adjuvant chemotherapy on progression-free survival.
  • In patients with locoregional bulky disease or with fixed inguinal lymph nodes, neoadjuvant chemotherapy will result in a partial response in 20-60% of patients and enables complete resection of the mass.
  • For the future, the use of taxane-based chemotherapy as described for squamous cell cancer of other origin might improve outcome.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoadjuvant Therapy. Penile Neoplasms / drug therapy
  • [MeSH-minor] Bleomycin / administration & dosage. Bleomycin / adverse effects. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Ifosfamide / administration & dosage. Ifosfamide / adverse effects. Lymph Node Excision. Lymphatic Metastasis / pathology. Male. Methotrexate / administration & dosage. Methotrexate / adverse effects. Neoplasm Staging. Penis / pathology. Penis / surgery. Survival Rate. Taxoids / administration & dosage. Taxoids / adverse effects. Treatment Outcome

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  • (PMID = 17846739.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Taxoids; 11056-06-7 / Bleomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate; TIP regimen
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5. Tsukamoto T, Yonese J, Kin T, Samejima T, Hasegawa Y, Fukui I, Ishikawa Y: [Carcinoma in situ of the penis rapidly progressing after carbon dioxide laser treatment]. Nihon Hinyokika Gakkai Zasshi; 2002 Mar;93(3):483-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Carcinoma in situ of the penis rapidly progressing after carbon dioxide laser treatment].
  • Laser treatment is considered to be effective in treating carcinoma in situ of the penis.
  • We, however, report a case with carcinoma in situ of the penis which developed invasive carcinoma and inguinal lymphnode metastases only 6 months after the laser treatment.
  • A 74-year-old man with pseudophimosis presented with redness of the glans penis.
  • No metastasis was suspected by physical examination and imaging studies.
  • Six months after the treatment, however, local recurrence was confirmed by the touch smear cytology, resulting in the partial amputation of the penis.
  • The histopathological examination revealed subepithelial and marked lymphatic invasion of the tumor and positive margin in the urethral stump (squamous cell carcinoma in situ).
  • Further, since bilateral superficial inguinal lymphnode swelling appeared, total amputation of the penis with perineal urethrotomy and pelvic/inguinal lymphnode dissection was performed subsequently.
  • The metastases to bilateral inguinal lymphnodes were confirmed histologically.
  • The patient received adjuvant chemotherapy and has been alive and well without evidence of disease 40 months after the initial treatment.
  • [MeSH-major] Carcinoma in Situ / pathology. Lasers / adverse effects. Penile Neoplasms / pathology
  • [MeSH-minor] Aged. Disease Progression. Humans. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local

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  • (PMID = 11968805.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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6. Thyavihally YB, Tongaonkar HB, Gupta S, Gujral S: Primary seminal vesicle adenocarcinoma presenting as isolated metastasis to penis responding to chemotherapy and hormonal therapy. Urology; 2007 Apr;69(4):778.e1-3
MedlinePlus Health Information. consumer health - Cancer Chemotherapy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary seminal vesicle adenocarcinoma presenting as isolated metastasis to penis responding to chemotherapy and hormonal therapy.
  • We report a rare case of isolated penile metastasis from seminal vesicle adenocarcinoma associated with ipsilateral renal agenesis in a 62-year-old man.
  • The sigmoidoscopy and metastatic workup findings were normal.
  • The patient received six cycles of 5-fluorouracil, leucovorin, and oxaliplatin chemotherapy and underwent bilateral orchiectomy.
  • The patient was symptomatically better, and the penile swelling and seminal vesicle mass had regressed considerably.
  • He later developed multiple lung metastases and died of the disease.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Antineoplastic Agents / therapeutic use. Orchiectomy. Penile Neoplasms / secondary. Penile Neoplasms / therapy. Seminal Vesicles
  • [MeSH-minor] Combined Modality Therapy. Genital Neoplasms, Male / pathology. Humans. Male. Middle Aged

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  • (PMID = 17445672.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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7. Uemura M, Mukai M, Fukuhara S, Kanno N, Nishimura K, Miyoshi S, Tanigaki T, Yoshida K, Kawano K: [A case of extramammary Paget's disease presenting with anuria]. Hinyokika Kiyo; 2002 May;48(5):311-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Physical examinations revealed a large nodular tumor extending from his penis to the lower abdomen.
  • He was diagnosed with penile tumor that had invaded into the retroperitoneal space.
  • Radiation therapy, low dose chemotherapy, and hormone therapy were performed, but he died of invasion and multiple metastasis of the tumor 5 months later.
  • [MeSH-major] Adenocarcinoma / complications. Anuria / etiology. Paget Disease, Extramammary / complications. Penile Neoplasms / complications

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  • (PMID = 12094717.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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8. Uphoff J, Woziwodzki J, Schattka SO, Kollias A: [Loss of differentiation of a prostate adenocarcinoma after hormone therapy: the example of a metastasis in the spongy body of the penis]. Aktuelle Urol; 2008 Sep;39(5):373-7
MedlinePlus Health Information. consumer health - Prostate Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Loss of differentiation of a prostate adenocarcinoma after hormone therapy: the example of a metastasis in the spongy body of the penis].
  • [Transliterated title] Differenzierungsverlust eines Adenokarzinoms der Prostata nach Hormontherapie: am Beispiel einer Schwellkörpermetastase des Penis.
  • Penile metastases are very uncommon.
  • Metastases in the penis only occur at an advanced state of the tumour and with a high dedifferentiation, e. g., ductal adenocarcinoma.
  • Often prior to the transformation an anti-androgen therapy has been undertaken.
  • At this state of the disease, there is only the possibility of a palliative therapy with a poor prognosis.
  • The increasing histological dedifferentiation of the tumour tissue can make it difficult or even impossible to identify the primary lesion.
  • [MeSH-major] Adenocarcinoma / secondary. Androgen Antagonists / therapeutic use. Antineoplastic Agents, Hormonal / therapeutic use. Carcinoma, Basal Cell / secondary. Carcinoma, Transitional Cell / secondary. Cell Transformation, Neoplastic / pathology. Diphosphonates / therapeutic use. Gonadotropin-Releasing Hormone / antagonists & inhibitors. Neoplasms, Multiple Primary / drug therapy. Penile Neoplasms / secondary. Prostatic Neoplasms / drug therapy
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Bone Neoplasms / drug therapy. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Bone Neoplasms / surgery. Combined Modality Therapy. Cystectomy. Diagnosis, Differential. Disease Progression. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Penis / pathology. Penis / surgery. Prostate / pathology. Prostate / surgery. Prostatectomy

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  • (PMID = 18798127.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Androgen Antagonists; 0 / Antineoplastic Agents, Hormonal; 0 / Biomarkers, Tumor; 0 / Diphosphonates; 33515-09-2 / Gonadotropin-Releasing Hormone
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9. Ketata S, Boulaire JL, Soulimane B, Bargain A: Metachronous metastasis to the penis from a rectal adenocarcinoma. Clin Colorectal Cancer; 2007 Sep;6(9):657-9
Hazardous Substances Data Bank. CETUXIMAB .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metachronous metastasis to the penis from a rectal adenocarcinoma.
  • Penile metastases arise most frequently from genitourinary cancers, but can also arise from tumors of the large bowel; other primary sites are extremely uncommon.
  • We report the case of a 59-year-old patient with 2 penile metastases from a rectal adenocarcinoma, which was discovered 26 years after abdominoperineal resection.
  • Penile biopsy was carried out and established the metastatic nature.
  • The patient underwent palliative chemotherapy treatment with cetuximab/irinotecan.
  • All previously reported cases of penile metastasis from the rectum are reviewed.
  • Regardless of the treatment options, the prognosis of such metastasis remains poor.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Rectal Neoplasms / pathology
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cetuximab. Humans. Immunohistochemistry. Male. Middle Aged. Palliative Care. Prognosis

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  • (PMID = 17945039.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 7673326042 / irinotecan; PQX0D8J21J / Cetuximab; XT3Z54Z28A / Camptothecin
  • [Number-of-references] 18
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10. Zheng FF, Zhang ZY, Dai YP, Liang YY, Deng CH, Tao Y: Metastasis to the penis in a patient with adenocarcinoma of lung, case report and literature review. Med Oncol; 2009;26(2):228-32
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis to the penis in a patient with adenocarcinoma of lung, case report and literature review.
  • Metastasis of lung cancer to the penis is very rare; it causes various clinical symptoms seriously affecting the quality of life.
  • Here, we report a case of penile metastasis secondary to pulmonary carcinoma along with a review of the literature.
  • One case of penile metastasis secondary to pulmonary carcinoma was detected in a 51-year-old patient who was admitted to the First Affiliated Hospital of Sun Yat-Sen University with persistent cough along with swelling of the perineum and penis.
  • The clinical features, diagnosis, and treatment of this disease along with a relevant literature are reviewed and discussed.
  • CT scan revealed lung mass, and a glans penis ulcer and enlargement of inguinal lymph nodes was discovered upon physical examination.
  • CT-guided percutaneous puncture of the lung mass revealed adenocarcinoma of lung, and biopsies of the glans penis ulcer and inguinal lymph nodes confirmed metastatic adenocarcinoma.
  • The patients received chemotherapy and died of acute pulmonary embolism in less than 2 months.
  • Metastasis of lung cancer to the penis is extremely rare.
  • Although treatment of penile metastasis is almost always palliative, early recognition may enhance survival for these patients.
  • [MeSH-major] Adenocarcinoma / pathology. Lung Neoplasms / pathology. Penile Neoplasms / secondary

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  • (PMID = 18975150.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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11. Feng T, Yohannan J, Allaf ME: Nonseminomatous germ cell tumor of the testes metastatic to the corpus cavernosum of the penis. Urology; 2010 Feb;75(2):255-6
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonseminomatous germ cell tumor of the testes metastatic to the corpus cavernosum of the penis.
  • Metastases to the penis are rare, with less than 200 cases reported.
  • These cases typically represent widely disseminated disease and are associated with a poor prognosis.
  • We present images of a case of a testicular nonseminomatous mixed germ cell tumor, which metastasized to the corpus cavernosum of the penis 8 months after a negative bilateral retroperitoneal lymph node dissection.
  • The patient received chemotherapy and experienced a complete response.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / secondary. Penile Neoplasms / secondary. Testicular Neoplasms / pathology

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19931126.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Sánchez-Ortiz R, Huang SF, Tamboli P, Prieto VG, Hester G, Pettaway CA: Melanoma of the penis, scrotum and male urethra: a 40-year single institution experience. J Urol; 2005 Jun;173(6):1958-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanoma of the penis, scrotum and male urethra: a 40-year single institution experience.
  • PURPOSE: Genitourinary melanoma is rare and classically associated with a poor prognosis.
  • We describe our experience with 10 patients with penile or urethral involvement.
  • RESULTS: Of 10 patients with penile or urethral melanoma 1997 American Joint Committee on Cancer melanoma pathological stage was T1 (depth less than 0.75 mm) in 4, T2 (0.75 to 1.5 mm) in 3 and T3 (1.51 to 4 mm) in 3.
  • Only 1 of 4 patients with clinically palpable inguinal nodes had inguinal metastases at lymphadenectomy (BILND) and 3 who underwent prophylactic superficial BILND had negative findings.
  • One patient died of melanoma that developed at a second primary site.
  • In all patients with penile melanoma the 5-year actuarial disease specific and recurrence-free survival rates were 80% and 60%, respectively, at a median followup of 39 months (range 20 to 210).
  • Three of the 6 patients had palpable inguinal nodes, of whom 2 died after chemotherapy for unresectable disease and 1 died of other causes 51 months after negative BILND.
  • The 3 men with clinically negative groins who did not undergo prophylactic BILND had distant (1) or regional (2) metastases and died of disease.
  • CONCLUSIONS: Partial penectomy or WLE provided effective local control for low stage penile or urethral melanomas and all scrotal lesions.
  • Patients showing clinically positive, proven metastasis died despite appropriate surgical procedures and multi-agent chemotherapy.
  • Prophylactic modified inguinal lymphadenectomy should be considered in select patients with penile, scrotal and anterior urethral melanoma.
  • [MeSH-major] Genital Neoplasms, Male / surgery. Melanoma / surgery. Penile Neoplasms / surgery. Scrotum / surgery. Urethral Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Disease-Free Survival. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Retrospective Studies. Survival Rate

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  • [CommentIn] J Urol. 2006 Apr;175(4):1574-5; author reply 1575-6 [16516049.001]
  • (PMID = 15879790.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Otto T, Suhr J, Krege S, Rübben H: [Therapy of advanced penis carcinoma]. Urologe A; 2003 Nov;42(11):1466-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Therapy of advanced penis carcinoma].
  • [Transliterated title] Die Therapie des fortgeschrittenen Peniskarzinoms.
  • Skin infiltration and locoregional lymph node extension in metastatic penile cancer leads to destruction in the inguinal and perineal region.
  • The obligatorily superinfected defects require tension-free and extended coverage with immediate myocutaneous flaps after surgical resection.
  • Data concerning a prospective study for neoadjuvant chemotherapy with CMB followed by surgical tumor resection with immediate myocutaneous flap reconstruction are presented.
  • In 15 patients (median age: 69.7 years) suffering from squamous cell carcinoma of the penis (Tx, N3, M1 cutis), a surgical excision of the tumor was performed after neoadjuvant chemotherapy (median:2.4 cycles) and antibiotic pretreatment.
  • All patients received coverage of the femoral vessels with a musculus sartorius transfer on both sides.
  • An extended (up to 45x30 cm) tension-free coverage of groin defects was performed in two patients with a unilateral M. tensor fasciae latae flap (TFL) and in eight patients with a bilateral TFL.
  • One patient received a M. gluteus maximus flap (GMFL) on both sides, three patients were treated with a combination of M. rectus abdominis flap (RFL) and TFL, and one patient received a combination of two TFL, one GMFL as well as one RFL.
  • Of 31 myocutaneous pedicle flaps, 2 developed distant necrosis of the flap, in which one GMFL and one TFL were affected.
  • The covering of groin defects by the use of myocutaneous flaps, such as the M. tensor fasciae latae, M. rectus abdominis, and M. gluteus maximus flap, is a method of first choice in the primary treatment of even bacterially contaminated wounds or after radiation therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Neoadjuvant Therapy. Penile Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antibiotic Prophylaxis. Bleomycin / administration & dosage. Bleomycin / adverse effects. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Graft Survival / drug effects. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Methotrexate / administration & dosage. Methotrexate / adverse effects. Microsurgery. Neoplasm Invasiveness. Neoplasm Staging. Skin / pathology. Superinfection / prevention & control. Surgical Flaps / blood supply. Surgical Wound Infection / prevention & control. Suture Techniques. Treatment Outcome. Wound Healing / drug effects

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  • (PMID = 14624345.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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14. Khan MA, Tao W, Mathews P, Potluri BS: Penile metastasis arising from transitional cell carcinoma of the urinary bladder. Urol Int; 2001;66(3):162-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile metastasis arising from transitional cell carcinoma of the urinary bladder.
  • Metastatic spread of transitional cell carcinoma of the bladder to the penis is very rare.
  • We present 1 such case in a 63-year-old man that was treated by total penectomy and adjuvant systemic chemotherapy.
  • [MeSH-major] Carcinoma, Transitional Cell / secondary. Penile Neoplasms / secondary. Urinary Bladder Neoplasms / pathology

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  • [Copyright] Copyright 2001 S. Karger AG, Basel
  • (PMID = 11316981.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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15. Bouchot O, Rigaud J: [Diagnosis and treatment of penis cancer]. Presse Med; 2010 Sep;39(9):871-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and treatment of penis cancer].
  • [Transliterated title] Diagnostic et traitement du cancer du pénis.
  • Penile cancer is a rare tumor in Europe and is therefore associated with risks of diagnostic delay for stage Ta-T1 tumors or pre-epitheliomatous lesions and of an inadequate treatment strategy.
  • Clinical examination by palpation is essential in primary tumors to look for infiltration in the corpus spongiosum and the tunica albuginea of the corpus cavernosa of the penis, and in the lymphatic drainage areas, in particular in the upper inner quadrant of the inguinal lymph nodes.
  • The work-up must include: a biopsy in the case of diagnostic doubt, lymph node aspiration in the case of palpable adenopathies, and whole-body computed tomography (CT).
  • Treatment of the primary tumor can include partial amputation for tumors infiltrating the corpus cavernosa, or conservative treatment for tumors limited to the glands if the diameter is less than 30 mm, after an initial circumcision.
  • Groups at risk of lymph node metastases have been defined as a function of the pathology results of their primary tumors.
  • In these groups at risk, or in the case of clinical lymph node metastasis, dissection of the lymph node has an important role, permitting 5-year survival rates greater than 80 % when the number of metastatic lymph nodes is ≤ 1-2.
  • In the case of more extensive lymph node spread, a combination of chemotherapy and surgery must be discussed in multidisciplinary meetings, especially for younger patients.
  • [MeSH-major] Penile Neoplasms / diagnosis. Penile Neoplasms / therapy
  • [MeSH-minor] Algorithms. Humans. Male. Neoplasm Staging

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20494544.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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16. Preis E, Jakse G: [The significance of inguinal lymphadenectomy in carcinoma of the penis]. Urologe A; 2006 Sep;45 Suppl 4:176-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The significance of inguinal lymphadenectomy in carcinoma of the penis].
  • The occurrence of inguinal lymph node metastases from squamous cell carcinoma of the penis depends on local tumor extension, tumor grade, and vascular invasion.
  • Whilst imaging techniques and fine needle biopsy can detect metastases to the inguinal nodes, resection of the superficial inguinal nodes remains the procedure of choice for diagnosis.
  • Resection of the sentinel lymph node marked by (99)Tc and dye has not yet been adequately evaluated as an alternative to be accepted as the standard method.When the superficial inguinal lymph nodes are found to harbor metastases the next step is a radical bilateral inguinal lymphadenectomy.
  • When metastases are found in two lymph nodes or extranodal tumor growth is observed, or imaging techniques reveal enlarged nodes in the pelvis the lymphadenectomy is extended to the pelvic nodes.
  • Chemotherapy and radiotherapy and the two combined have not been tested for efficacy, but are used individually before and after surgery, depending on the local tumor extent.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lymph Node Excision / methods. Penile Neoplasms / surgery
  • [MeSH-minor] Germany. Humans. Inguinal Canal. Lymphatic Metastasis / pathology. Male. Neoplasm Invasiveness. Neoplasm Staging. Penis / pathology. Postoperative Complications / etiology. Practice Guidelines as Topic. Prognosis. Sentinel Lymph Node Biopsy

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  • (PMID = 16933120.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 46
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17. Pow-Sang MR, Benavente V, Pow-Sang JE, Morante C, Meza L, Baker M, Pow-Sang JM: Cancer of the penis. Cancer Control; 2002 Jul-Aug;9(4):305-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer of the penis.
  • BACKGROUND: Cancer of the penis is an uncommon malignancy in developed countries, but the incidence is as high as 17% of all male cancers in some undeveloped countries.
  • The surgical management of this disease has improved due to better knowledge of risk for metastasis and newer imaging technologies to assess the regional lymph nodes.
  • METHODS: We review the literature on incidence, etiology, pathology, clinical presentation, staging, and management of penile cancer.
  • The recent use of a modified lymph node dissection has minimized morbidity.
  • Current chemotherapy agents are ineffective in this disease.
  • The use of a modified lymph node dissection in selected patients has decreased morbidity.
  • Effective chemotherapy agents are needed in the management of advanced penile cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Penile Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Lymph Nodes / radionuclide imaging. Male. Middle Aged. Neoplasm Staging. Sentinel Lymph Node Biopsy. Urologic Surgical Procedures, Male / methods

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  • (PMID = 12228756.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 82
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18. Donate Moreno MJ, Ruiz Mondejar R, Giménez Bachs JM, Pastor Navarro H, Salinas Sánchez AS, Virseda Rodríguez JA: [Malignant melanoma of the penis. Report on one case]. Arch Esp Urol; 2005 Sep;58(7):672-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant melanoma of the penis. Report on one case].
  • [Transliterated title] Melanoma mauligno de pene. Aportación de un caso clínico.
  • OBJECTIVES: Due to the fact that melanoma of the penis is rare, we perform a bibliographic review about the subject and analyze the diagnostic criteria, clinical stages and therapeutic options.
  • RESULTS: 85-year-old male who presented with hematuria and a red brownish irregular elevated lesion in the glans penis.
  • CONCLUSIONS: Melanoma of the penis is a rare tumoral entity.
  • It accounts for about 1% of all penile malignant pathologies.
  • It has bad prognosis due to fast metastosic dissemination (regional lymph nodes and other organs) and delayed diagnosis.
  • First choice treatment is partial penectomy with or without bilateral inguinal lymphadenectomy (depending upon degree of tumor invasiveness).
  • In cases with metastasis treatment is palliative with chemotherapy and immunotherapy
  • [MeSH-major] Melanoma. Penile Neoplasms

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  • (PMID = 16294791.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 7
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19. Añibarro Laca E, Pérez-Irezabal Pindado JC, Ibáñez Calle T, Llarena Ibarguren R: [Metastases from a rectal adenocarcinoma to the prepuce]. Arch Esp Urol; 2006 Sep;59(7):737-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastases from a rectal adenocarcinoma to the prepuce].
  • [Transliterated title] Metastasis subcutáneas en prepucio secundarias a adenocarcinoma de recto.
  • OBJECTIVE: We report one case of metastatic dissemination of a rectal adenocarcinoma to the prepuce.
  • METHODS: 61-year-old patient with the diagnosis of rectal adenocarcinoma treated 18 months before by surgery and chemotherapy.
  • He presents with a painful enlargement of the penis associated with outgrowing erythematous lesions in the skin of the prepuce that bled on touch and did not allow the vision of the meatus and the glans penis.
  • Physical examination showed the presence of hypogostric, penile and scrotal lymphedema.
  • RESULTS: The pathologic study reported a moderately differentiated intestinal type adenocarcinoma with high mitotic index infiltrating the squamous cell flat epithelium of the prepuce.
  • CONCLUSIONS: Although extremely rare, tumor implants in the prepuce secondary to extra urologic tumors are exceptional.
  • Surgical excision confirms the origin and may avoid bleeding and discomfort, and also may help with catheterization, which is many times necessary in the final stages.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Rectal Neoplasms / pathology

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  • [CommentIn] Arch Esp Urol. 2006 Nov;59(9):926; author reply 927 [17190224.001]
  • (PMID = 17078400.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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20. García Rodríguez J, Fernández Gómez JM, Rodríguez Martínez JJ, Rodríguez Faba O, Jalón Monzón A, San Martín Blanco A, Martínez Gómez FJ, Sánchez Trilla A, Martín Benito JL, Escaf Barmadah S, Regadera Sejas J: [Clinical course of epidermoid carcinoma of the penis in our series]. Arch Esp Urol; 2003 Jan-Feb;56(1):30-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical course of epidermoid carcinoma of the penis in our series].
  • [Transliterated title] Análisis de la evolución del carcinoma epidermoide de pene en nuestra serie.
  • OBJECTIVES: To study the evolution of 49 patients with squamous cell carcinoma of the penis.
  • METHODS: 49 patients who underwent surgery for squamous cell carcinoma of the penis (30 partial penile amputations, 11 total amputations and 7 circumcisions).
  • 27 inguinal lymphadenectomies, superficial, profound and ilio-obturator (2 cases), were performed due to persistent lymph nodes after penile amputation despite of antibiotic treatment for 4 weeks, or to high grade primary tumour.
  • 13 patients were found to have lymph node metastases after treatment, receiving posterior adjuvant treatment with radiotherapy, chemotherapy or a combination of them.
  • Patients were followed in relation to stage, cell differentiation degree, and presence or absence of positive lymph nodes and distant metastases.
  • Lymph node metastasis were detected in 13 patients (26.53%) after lymph node dissection.
  • 6 patients died from tumour dissemination, 2 of them were T2G2, one T2G1, and three T1G2; two additional patients died from causes different from the tumour, all of them being N+ at the time of diagnosis.
  • CONCLUSIONS: Penile squamous cell carcinoma is an aggressive tumour the evolution of which mainly depends on the local-regional stage at the time of diagnosis and cell differentiation; these factors will condition lymphadenectomy versus observation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Penile Neoplasms / pathology. Penile Neoplasms / surgery

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  • (PMID = 12701478.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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21. Antonescu CR, Rosenblum MK, Pereira P, Nascimento AG, Woodruff JM: Sclerosing epithelioid fibrosarcoma: a study of 16 cases and confirmation of a clinicopathologically distinct tumor. Am J Surg Pathol; 2001 Jun;25(6):699-709
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing epithelioid fibrosarcoma: a study of 16 cases and confirmation of a clinicopathologically distinct tumor.
  • Sclerosing epithelioid fibrosarcoma (SEF) is an uncommon tumor of deep soft tissues, originally described in 1995 by Meis-Kindblom et al.
  • The group consisted of six male and 10 female patients (age range, 14-55 years; mean age, 40 years), and the tumors were located in a limb or limb girdle (n = 7), base of the penis (n = 1), back or chest wall (n = 3), and head and neck (n = 5).
  • Tumor size ranged from 3.7 to 22 cm (mean, 8.9 cm).
  • The only consistent immunohistochemical finding was a strong, diffuse reactivity of tumor cells for vimentin.
  • Bone invasion and tumor necrosis, features not reported before, were found in six cases each.
  • Treatment consisted of intralesional excision (n = 2), attempted wide local excision (n = 11), and amputation (n = 3), with either adjuvant radiation therapy (n = 9) or chemotherapy (n = 3).
  • Follow-up of at least 1 year in 14 cases revealed persistent disease or local recurrence in seven patients (50%), and distant metastasis in 12 patients (86%).
  • Eight patients (57%) died of disease 16 to 86 months after diagnosis.
  • SEF shares some pathologic features with two other fibrosing fibrosarcomas, low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes, but in the authors' experience behaves clinically as a fully malignant sarcoma.
  • [MeSH-major] Fibrosarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 11395547.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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22. Matuszewska K, Matuszewski M, Kowalczyk A, Jassem J: Penile metastases from urogenital primaries. Neoplasma; 2002;49(5):346-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile metastases from urogenital primaries.
  • Metastatic tumors of the penis are rare.
  • They are usually secondary to primaries of the genitourinary and gastrointestinal tracts.
  • This entity is usually accompanied by distressing symptoms like dysuria, pain, induration, swelling of the penis and priapism, making immediate intervention necessary.
  • Different methods of treatment are used to achieve the palliative effect: local surgical excision, penis amputation, radiotherapy or chemotherapy.
  • Nevertheless, the prognosis is poor, because the disease is already disseminated and in most cases other metastases will occur soon.
  • [MeSH-major] Penile Neoplasms / secondary. Penile Neoplasms / therapy. Urogenital Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma / diagnosis. Carcinoma / secondary. Carcinoma / therapy. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis

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  • (PMID = 12458336.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovakia
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23. Sofikerim M, Gülmez I, Tokat F, Er O, Gülmez I: Epidermoid carcinoma of the lung with isolated penile metastasis. Can J Urol; 2007 Aug;14(4):3643-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermoid carcinoma of the lung with isolated penile metastasis.
  • We report a case of epidermoid-cell carcinoma of the lung that developed a metastatic lesion in the penis.
  • He was started on an adjuvant chemotherapy protocol consisting of cisplatin and paclitaxel.
  • He was admitted to our urology clinic with obstructive symptoms during urination and pain during penile erection.
  • Physical examination revealed a firm, 3 cm x 2 cm palpable mass on the radix of his penis.
  • A fine-needle aspiration biopsy of the penile mass revealed epidermoid carcinoma that was consistent with lung cancer.
  • The patient was considered to have penile metastasis from epidermoid carcinoma of the lung.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Lung Neoplasms / pathology. Penile Neoplasms / secondary
  • [MeSH-minor] Biopsy, Needle. Disease Progression. Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Staging. Urination Disorders / etiology

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  • (PMID = 17784986.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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24. de los Rios Osorio J, Castro Alvarez EA: [Analysis of 5000 vasectomies at a family planning clinic in Medellin-Colombia]. Arch Esp Urol; 2003 Jan-Feb;56(1):53-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To study the evolution of 49 patients with squamous cell carcinoma of the penis.
  • METHODS: 49 patients who underwent surgery for squamous cell carcinoma of the penis (30 partial penile amputations, 11 total amputations and 7 circumcisions).
  • 27 inguinal lymphadenectomies, superficial, profound and ilio-obturator (2 cases), were performed due to persistent lymph nodes after penile amputation despite of antibiotic treatment for 4 weeks, or to high grade primary tumour.
  • 13 patients were found to have lymph node metastases after treatment, receiving posterior adjuvant treatment with radiotherapy, chemotherapy or a combination of them.
  • Patients were followed in relation to stage, cell differentiation degree, and presence or absence of positive lymph nodes and distant metastases.
  • Lymph node metastasis were detected in 13 patients (26.53%) after lymph node dissection.
  • 6 patients died from tumour dissemination, 2 of them were T2G2, one T2G1, and three T1G2; two additional patients died from causes different from the tumour, all of them being N+ at the time of diagnosis.
  • CONCLUSIONS: Penile squamous cell carcinoma is an aggressive tumour the evolution of which mainly depends on the local-regional stage at the time of diagnosis and cell differentiation; these factors will condition lymphadenectomy versus observation.

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  • (PMID = 12701481.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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25. Mobilio G, Ficarra V: Genital treatment of penile carcinoma. Curr Opin Urol; 2001 May;11(3):299-304

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genital treatment of penile carcinoma.
  • Squamous penile carcinoma is an uncommon neoplastic disease with an incidence of one in 100 000 men per year in Western countries.
  • The role of penile-sparing treatment represents one of the three main issues in management of squamous carcinoma of the penis.
  • Most authors consider conservative therapy as an indicated alternative treatment to partial or total penectomy in small size, low stage and grade tumours.
  • At present, external or interstitial beam radiotherapy and lasertherapy represent the best available conservative therapeutic approaches.
  • An early inguinal lymphadenectomy is indicated especially in patients with a high occult nodal micrometastases risk (G3 and pT2-4).
  • The third point of discussion is represented by the use of chemotherapy in patients with metastatic disease.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Penile Neoplasms / therapy
  • [MeSH-minor] Humans. Lymph Node Excision. Lymphatic Metastasis. Male

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  • (PMID = 11371784.001).
  • [ISSN] 0963-0643
  • [Journal-full-title] Current opinion in urology
  • [ISO-abbreviation] Curr Opin Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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26. Miwa K: [Sentinel node concept and its application for cancer surgery]. Nihon Geka Gakkai Zasshi; 2000 Mar;101(3):307-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The sentinel node is the first lymph node that drains a primary tumor.
  • A negative sentinel lymph node accurately predicts the absence of metastasis to any other regional lymph nodes.
  • A higher rate of feasibility, sensitivity, specificity, and diagnostic accuracy in sentinel lymph node mapping has been demonstrated of cancer of the breast, penis, and vulva and in malignant melanoma.
  • Intraoperative endoscopic lymphatic mapping, which we developed for gastric cancer in 1994, was also useful in accurately predicting nodal status in 163 early-stage gastric cancer patients: the rate of sensitivity, specificity, and accuracy was 91%, 100%, and 98%, respectively.
  • Therefore if the sentinel lymph node biopsy is free of metastasis, limited surgery such as wedge resection, segmental resection, pylorus-preserving gastrectomy, or proximal gastrectomy is indicated.
  • The tumor-free sentinel lymph node allows dissection of regional lymph nodes to be avoided and results in an improved quality of life in postoperative patients.
  • Further progress may change the mode of nodal dissection and the indications for adjuvant chemotherapy for cancer.
  • [MeSH-major] Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Neoplasms / therapy

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  • (PMID = 10773998.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] JAPAN
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27. Marconnet L, Bouchot O, Culine S, Avances C, Rigaud J, membres du CCAFU-OGE: [Treatment of lymph nodes in epidermoid carcinoma of the penis: review of literature by the Committee of Cancerology of the French Association of Urology-External Genital Organs Group (CCAFU-OGE)]. Prog Urol; 2010 May;20(5):332-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of lymph nodes in epidermoid carcinoma of the penis: review of literature by the Committee of Cancerology of the French Association of Urology-External Genital Organs Group (CCAFU-OGE)].
  • [Transliterated title] Prise en charge ganglionnaire dans le carcinome épidermoïde du pénis: revue de la littérature par le comité de cancérologie de l'Association française d'urologie-groupe organes génitaux externes (CCAFU-OGE).
  • INTRODUCTION: Invasive lymph nodes are an independent factor of prognosis and essential for the survival of patients with cancer of the penis.
  • The aim of this article is to analyse published research results on the diagnosis and treatment of lymph nodes in cancer of the penis.
  • MATERIAL AND METHOD: Bibliographic research on Medline was carried out using the terms penile carcinoma, lymph node dissection, lymphadenectomy, survival, chemotherapy and radiotherapy.
  • RESULTS: The risk of lymph node metastasis depends on the stage of the primitive tumour, its histological grade, the presence of venous and lymphatic embolus and the presence of palpable lymph nodes (classification into risk groups by the European Association of Urology [EAU]).
  • A diagnosis of suspected adenopathy based on clinical examination associated with FNA biopsy is essential.
  • The search for the sentinel lymph node although interesting remains to be defined, especially in patients who have no palpated adenopathy but are at risk of metastasis.
  • Not only is surgery on inguinal lymph nodes the only reliable way of confirming an invasive metastatic lymph node, it also plays a therapeutic and prognostic role for patients who have a tumour of the penis which risks spreading to lymph nodes (intermediate or high risk according to EAU).
  • The type of dissection is in function with the clinical examination: a radical inguinal dissection is recommended in the case of palpated adenopathy and a modified inguinal dissection is recommended if there is no palpated adenopathy, this should be radicalised in the case of metastatic adenopathy on histological examination.
  • Neo-adjuvant or adjuvant chemotherapy would appear to play a interesting role when combined with surgery for certain patients without there being currently being precise consensus because of the lack of documented cases.
  • CONCLUSION: Lymph node dissection alone has a therapeutic role in patients who have reached metastasis of lymph nodes (stage pN1).
  • However, it remains insufficient for patients who have metastatic infiltration of more than 2 lymph nodes (stage > or =pN2).
  • Consequently, it would seem important to develop multimodal approaches in the treatment of these patients in order to increase the rate of response to treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lymph Node Excision. Penile Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. France. Humans. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Societies, Medical. Urology

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20471577.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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28. Peppler C, Weissert D, Kappe E, Klump S, Kramer M, Reinacher M, Neiger R: Osteosarcoma of the penile bone (os penis) in a dog. Aust Vet J; 2009 Jan-Feb;87(1):52-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteosarcoma of the penile bone (os penis) in a dog.
  • Osteosarcoma of the penile bone was diagnosed in a 5-year-old neutered male Rottweiler with recurrent dysuria.
  • Imaging and cytological findings raised the suspicion for an osteosarcoma and ablation of the entire penis and scrotal urethrostomy was performed.
  • The diagnosis was confirmed histologically.
  • The dog survived without adjuvant chemotherapy for 12 months when multiple tumours in the thorax and abdomen led to it being euthanased.
  • Penile osteosarcoma is a rare disease, but must be considered as a differential diagnosis in dogs presenting with dysuria.
  • This is the second recorded case of a penile osteosarcoma in a dog, but the first with a detailed description of the diagnosis, treatment and outcome.
  • [MeSH-major] Bone Neoplasms / veterinary. Dog Diseases / diagnosis. Osteosarcoma / veterinary. Penile Neoplasms / veterinary
  • [MeSH-minor] Animals. Dogs. Fatal Outcome. Male. Neoplasm Metastasis

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  • (PMID = 19178479.001).
  • [ISSN] 0005-0423
  • [Journal-full-title] Australian veterinary journal
  • [ISO-abbreviation] Aust. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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29. Kim B, Garcia F, Touma N, Moussa M, Izawa JI: A rare case of penile cancer in situ metastasizing to lymph nodes. Can Urol Assoc J; 2007 Nov;1(4):404-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of penile cancer in situ metastasizing to lymph nodes.
  • Penile carcinoma in situ, or Queyrat's erythroplasia, is a rare condition of the glans penis.
  • This lesion has been associated with invasive squamous cell carcinoma; however, metastasis without an invasive component is extremely rare.
  • There have only been 2 documented cases with metachronous metastases.
  • We report a third case in which metastases were diagnosed at presentation.
  • The patient was a 51-year-old man who presented with a glans penile lesion and bilateral inguinal masses later determined to be carcinoma in situ with metastases to the inguinal and pelvic lymph nodes.
  • He subsequently underwent a partial penectomy and lymphadenectomy followed by adjuvant chemotherapy and radiation.
  • This case is discussed, along with a brief review of the literature.

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  • (PMID = 18542829.001).
  • [ISSN] 1911-6470
  • [Journal-full-title] Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • [ISO-abbreviation] Can Urol Assoc J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2422981
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30. Sawada A, Segawa T, Nakanishi S, Kinoshita H, Yamamoto S, Kamoto T, Ogawa O: [Prostate cancer with penile metastasis: a case report]. Hinyokika Kiyo; 2005 Nov;51(11):771-3
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  • [Title] [Prostate cancer with penile metastasis: a case report].
  • A 77-year-old man presented with complaints of dysuria, nocturia and painless nodule on his penis.
  • Pathological examinations on prostate and penile biopsy specimens revealed prostate adenocarcinoma with penile metastasis.
  • The patient was diagnosed as having prostate cancer stage D2 (T4N1M1) with bone, lymph node and penile metastases.
  • There was no response to initial hormonal therapy with the surgical castration and diethylstilbestrol.
  • However, decrease of the tumor size, as well as PSA and CA19-9 values were achieved after the combined chemotherapy with Estramustine, Paclitaxel and Carboplatin.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Carboplatin / administration & dosage. Combined Modality Therapy. Estramustine / administration & dosage. Humans. Male. Orchiectomy. Paclitaxel / administration & dosage. Prostate-Specific Antigen / blood

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  • (PMID = 16363713.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 35LT29625A / Estramustine; BG3F62OND5 / Carboplatin; EC 3.4.21.77 / Prostate-Specific Antigen; P88XT4IS4D / Paclitaxel
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31. Smith Y, Hadway P, Ahmed S, Perry MJ, Corbishley CM, Watkin NA: Penile-preserving surgery for male distal urethral carcinoma. BJU Int; 2007 Jul;100(1):82-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile-preserving surgery for male distal urethral carcinoma.
  • OBJECTIVE: To evaluate medium-term outcome data from patients with distal urethral cancers treated with penile-preserving surgery.
  • Tumours were staged according to the Tumour-Node-Metastasis classification and the patients offered penile-preserving surgery when tumours were limited to the glanular or penile urethra.
  • RESULTS: All 18 patients were suitable for penile-preserving surgery; the procedures were: three hypospadias formation with or without topical chemotherapy; four buccal mucosa urethroplasty; three glansectomy and reconstruction; six glansectomy, distal corporectomy, reconstruction and hypospadias formation; two urethrectomy with or with no excision of adjacent tunica albuginea.
  • There were no local recurrences; four patients with regional nodal disease progressed and of these, two died from metastatic disease, and one died from an unrelated condition.
  • CONCLUSION: Medium-term data show that penile-preserving surgery is a feasible treatment for men with distal urethral carcinoma, providing excellent local control without prejudicing survival; a longer follow-up is needed.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Penis / surgery. Urethral Neoplasms / surgery. Urologic Surgical Procedures, Male / standards
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Feasibility Studies. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies. Treatment Outcome

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  • (PMID = 17488307.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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32. Matveev VB, Khalaf'ian EA, Volkova MI, Gurariĭ LL, Romanov VA: [Organ-saving treatment of penile cancer]. Urologiia; 2004 Mar-Apr;(2):26-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Organ-saving treatment of penile cancer].
  • Conservative penis-salvage treatment provides a complete local effect in 55% cases, preservation of the penis in 51.4% patients without a fall in long-term specific and recurrence-free survival compared to penectomy and can be recommended as an alternative to penis amputation in patients with stages Tis-T2.
  • Removal of a penile tumor raises efficacy of salvage treatment and insignificantly increases survival.
  • Application of surgical treatment only is associated with a high rate of local recurrences.
  • Chemoradiotherapy in penile cancer is significantly more effective vs each method alone.
  • Radiation in a total focal dose more than 60 Gy improves local control over the tumor.
  • Most effective are schemes of chemotherapy based on bleomycin.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / surgery. Neoplasm Recurrence, Local. Penile Neoplasms / surgery. Urologic Surgical Procedures, Male / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 15114748.001).
  • [ISSN] 1728-2985
  • [Journal-full-title] Urologii︠a︡ (Moscow, Russia : 1999)
  • [ISO-abbreviation] Urologiia
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia
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33. Zheng FF, Liang YY, Guo YS, Dai YP, Zheng KL: [Diagnosis and therapy for penile cancer: a report of 46 cases with literature review]. Ai Zheng; 2008 Sep;27(9):962-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and therapy for penile cancer: a report of 46 cases with literature review].
  • BACKGROUND & OBJECTIVE: Penile cancer is an uncommon malignancy, which is mainly treated by surgery, radiation and chemotherapy.
  • This study was to investigate reasonable curative methods for penile cancer.
  • METHODS: Medical records of 46 patients with penile cancer in the Department of Urology, The First Affiliated Hospital of Sun Yat-sen University between Jan.
  • Prognosis of patients with pelvic lymph node metastasis was poor.
  • Two patients who had pelvic lymph node metastasis died of lung metastasis within two years after surgery.
  • CONCLUSIONS: Partial penectomy is an appropriate and effective management for penile cancer.
  • Lymph node metastasis is an important prognostic factor for penile cancer.
  • Patients with ilioinguinal lymph node metastasis should receive lymphadenectomy as early as possible to improve the therapeutic effect.
  • The prognosis is poor for patients with pelvic lymph node metastases.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Penile Neoplasms / surgery. Penis / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Verrucous / pathology. Carcinoma, Verrucous / surgery. Carcinoma, Verrucous / therapy. Chemotherapy, Adjuvant. Follow-Up Studies. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Paget's Disease, Mammary / pathology. Paget's Disease, Mammary / surgery. Paget's Disease, Mammary / therapy. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 18799036.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 12
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34. Ferreira U, Reis LO, Ikari LY, da Silva W Jr, Matheus WE, Denardi F, Stopiglia RM, Menezes FH: Extra-anatomical transobturator bypass graft for femoral artery involvement by metastatic carcinoma of the penis: report of five patients. World J Urol; 2008 Oct;26(5):487-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-anatomical transobturator bypass graft for femoral artery involvement by metastatic carcinoma of the penis: report of five patients.
  • OBJECTIVES: Squamous cell carcinoma (SCC) of the penis with inguinal lymph node involvement aggravates prognosis and can cause femoral artery bleeding, hemorrhagic shock and even death.
  • The objective of this study is to describe the use of extra-anatomical transobturator bypass graft for femoral artery involvement by metastatic carcinoma of the penis.
  • CASUISTIC AND METHOD: Five patients with SCC and inguinal lymphatic metastasis involving the femoral vessels, who underwent extra-anatomical arterial bypass through obturator foramen between 1999 and 2007, were reviewed.
  • RESULTS: After extra-anatomical transobturator bypass, all patients presented distal pulses.
  • The mean time of surgery was 6 h.
  • Two patients chose not to undergo inguinal resection, opting for palliative chemotherapy after the vascular procedure.
  • The average follow-up period was 12 months and four patients have died-three due to pulmonary metastasis, and one due to acute myocardial infarct.
  • CONCLUSIONS: The use of the transobturator bypass can benefit patients presenting with penile SCC and inguinal lymph nodes metastasis involving the femoral vessels, allowing resection of extensive tumor lesions, as well as avoidance of local complications.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Femoral Artery / surgery. Penile Neoplasms / pathology. Vascular Neoplasms / secondary. Vascular Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Blood Vessel Prosthesis. Humans. Lymphatic Metastasis. Male. Middle Aged. Saphenous Vein / transplantation. Vascular Surgical Procedures / methods

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  • (PMID = 18581120.001).
  • [ISSN] 0724-4983
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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35. Yoshinaga A, Hayashi T, Ishii N, Ohno R, Terao T, Kamata S, Watanabe T, Yamada T: [Vesicorectal fistula caused by pelvic metastasis of penile cancer: a case report]. Hinyokika Kiyo; 2005 Jan;51(1):53-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Vesicorectal fistula caused by pelvic metastasis of penile cancer: a case report].
  • Tumor biopsy revealed squamous cell carcinoma.
  • Although he was given radiation therapy and subcutaneous injection therapy of bleomycin, viable cancer cells remained.
  • Then he was given combination chemotherapy of bleomycin and cisplatin, and paint therapy of bleomycin ointment.
  • Local recurrence with a cauliflower-like tumor occurred five years after the chemotherapy.
  • Then we performed total penectomy and reconstructive surgery of penis.
  • Computerized tomography of pelvis demonstrated a mass 3 cm in diameter in the anterior portion of anal and cystogram demonstrated a vesicorectal fistula.
  • Pathological examination of tissue around the fistula revealed squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Pelvic Neoplasms / secondary. Penile Neoplasms / pathology. Rectal Fistula / etiology. Urinary Bladder Fistula / etiology

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  • (PMID = 15732344.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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36. Borchers H, Jakse G: [Lymphadenectomy for penile cancer. Diagnostic and prognostic significance as well as therapeutic benefit]. Urologe A; 2005 Jun;44(6):657-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lymphadenectomy for penile cancer. Diagnostic and prognostic significance as well as therapeutic benefit].
  • Lymphadenectomy is an essential part of diagnosis and treatment of the squamous cell carcinoma of the penis.
  • Lymphadenectomy is performed depending on various characteristics of penile cancer such as depth of invasion, tumor grade, invasion into the corpora cavernosa, invasion into vascular and lymphatic vessels.
  • The limits of lymphadenectomy are extended to the radical type of dissection when the frozen section indicates cancer.
  • Neoadjuvant chemotherapy is reasonable for patients with bulky nodes fixed to the skin or fascia because this improves respectability, freedom from local recurrence and increases survival.
  • Adjuvant chemo- and/or radio-therapy are reserved for extended disease or palliative situations.
  • [MeSH-major] Lymph Node Excision / methods. Lymph Nodes / pathology. Lymph Nodes / surgery. Penile Neoplasms / pathology. Penile Neoplasms / surgery. Prostatectomy / methods. Risk Assessment / methods
  • [MeSH-minor] Clinical Trials as Topic. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Practice Guidelines as Topic. Practice Patterns, Physicians'. Preoperative Care / methods. Prognosis. Risk Factors

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  • (PMID = 15891865.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 21
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37. Hori J, Kato Y, Iwata T, Taniguchi N, Hashimoto H, Yachiku S: [A case of penile malignant melanoma]. Hinyokika Kiyo; 2003 Aug;49(8):493-6
MedlinePlus Health Information. consumer health - Melanoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of penile malignant melanoma].
  • In January, 2001, with complaints of black nodules and bleeding from the glans of the penis to the foreskin.
  • Clinical diagnosis was penile malignant melanoma.
  • Cystoscopy and urethrography revealed urethral invasion of malignant melanoma, and magnetic resonance imaging (MRI) of the penis revealed invasion to prostate, and pelvic lymph node metastases in abdominal compuled tomography (CT) but no organ metastases.
  • The pathological findings were nodular malignant melanoma, pT4bN2bM1a, and the surgical margin was positive.
  • After these therapies, chemotherapy was performed.
  • Five months later, CT revealed multiple lung and brain metastases, and radiation therapy and chemotherapy were performed.
  • Review of the literature revealed that our patient is the thirtieth reported case of penile malignant melanoma in Japan since 1924.
  • [MeSH-major] Melanoma / secondary. Penile Neoplasms / pathology. Urethral Neoplasms / pathology
  • [MeSH-minor] Aged. Combined Modality Therapy. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Prostatic Neoplasms / pathology

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  • (PMID = 14518390.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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38. Chabannes E, Wallerand H, Bernardini S, Debière F, Allouc H, Bittard H: [Malignant penile melanoma]. Prog Urol; 2000 Feb;10(1):101-5; discussion 105-6
MedlinePlus Health Information. consumer health - Melanoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant penile melanoma].
  • The authors report the case of a very large, obstructive malignant melanoma (MM.) of the prepuce, encasing all of the distal extremity of the penis, and discovered at a late metastatic stage (regional lymph node metastasis).
  • Palliative treatment, consisting of partial penectomy associated with a complementary induction and maintenance chemotherapy did not achieve any objective response at one year. MM. of the penis are rare urological tumours, including MM of the penis and MM of the male urethra (exclusively mucosal involvement).
  • The diagnosis of MM of the penis must be considered in any case of black or brown lesion of the glans, which is the most frequent site.
  • The prognosis is determined by the clinical stage (BRACKEN and DIOKNO classification) and by the depth and level of tumour invasion (BRESLOW index and CLARK's degree of dermal invasion).
  • The 5-year survival is inversely proportional to the tumour thickness.
  • The treatment of MM of the penis is surgical; the extent of resection and the indication for lymph node dissection depend on the patient's age, sexuality, and the stage of the disease and depth of tumour invasion.
  • [MeSH-major] Melanoma / pathology. Penile Neoplasms / pathology

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  • (PMID = 10785929.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] FRANCE
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