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Items 1 to 21 of about 21
1. Kobayashi S, Nakajima T, Iizasa T, Tsujimura H, Itami M, Kimura H: Pulmonary metastasis with endobronchial spread from sinonasal melanoma during a 9-year follow-up. Intern Med; 2010;49(8):777-9
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  • [Title] Pulmonary metastasis with endobronchial spread from sinonasal melanoma during a 9-year follow-up.
  • A 60-year-old woman was diagnosed with pulmonary metastasis with endobronchial spread of sinonasal melanoma 9 years after the initial treatment.
  • She had originally been diagnosed with sinonasal malignant melanoma and received chemotherapy combined with carbon ion radiotherapy.
  • During routine follow-up, chest CT showed a nodular lesion on the left upper lung lobe.
  • Bronchoscopic examination showed diffuse melanosis without intrinsic masses from the left main bronchus to the peripheral bronchial mucosa.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / secondary. Lung Neoplasms / diagnosis. Melanoma / diagnosis. Melanoma / secondary. Nose Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Female. Follow-Up Studies. Humans. Middle Aged

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  • (PMID = 20424370.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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2. Shen Q, Yao Y, Teng X, Zhou J: Endobronchial metastasis from prostate cancer mimicking primary lung cancer. Intern Med; 2010;49(15):1613-5
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  • [Title] Endobronchial metastasis from prostate cancer mimicking primary lung cancer.
  • Endobronchial metastasis from prostate cancer is a rare neoplasm which metastasizes to the proximal central or subsegmental bronchus, in a bronchoscopically visible range.
  • We present a 72-year-old man with a left superior lobar bronchus mass, intrapulmonary metastases, and bone metastases, mimicking primary lung bronchogenic carcinoma.
  • Pathomorphology and immunohistochemistry of the mucosa specimen with P504S, PSA revealed the diagnosis of pulmonary metastases from prostate cancer.
  • The patient was treated by hormonal treatment and chemotherapy.
  • He was in remission thirteen months after diagnosis.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / secondary. Prostatic Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Follow-Up Studies. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male


3. Mroz RM, Korniluk M, Swidzinska E, Dzieciol J, Czaban J, Panek B, Chyczewska E: Lung mass in a 28-year-old male: a case report of a rare tumor. Eur J Med Res; 2010 Nov 4;15 Suppl 2:95-7
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  • [Title] Lung mass in a 28-year-old male: a case report of a rare tumor.
  • He was referred with suspicion of lung tumor to our institution.
  • Chest X-ray showed almost total atelectasis of the right lung with compensatory overinflation of the contralateral lung.
  • Using computed tomography (CT), a lesion of diameter of 19.3 x 14.1 x 19.1 cm in the right lung, pleuritis, Th3 osteolysis, and compensatory overinflation of the left lung was seen.
  • Bronchoscopy revealed a total obstruction of the right main bronchus due to submucosal infiltration and compression of the right main bronchus with negative histology of bronchial biopsy specimens.
  • Transthoracic fine needle aspiration revealed celullae suspectae probabiliter neoplasmaticae suggesting tumor fusocellularis.
  • Subsequent fine needle aspirations of the thorax and liver revealed fibrolamellar hepatocarcinoma and carcinoma adenoides of the lung.
  • Patient underwent chemotherapy with 5-FU/DDP/VCR with no response.
  • This report presents a case of a rare lung metastasis from FL-HCC.
  • [MeSH-major] Liver Neoplasms / pathology. Lung Neoplasms / secondary

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  • (PMID = 21147631.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] Fibrolamellar hepatocellular carcinoma
  • [Other-IDs] NLM/ PMC4360372
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4. Celikoglu SI, Celikoglu F, Goldberg EP: Endobronchial intratumoral chemotherapy (EITC) followed by surgery in early non-small cell lung cancer with polypoid growth causing erroneous impression of advanced disease. Lung Cancer; 2006 Dec;54(3):339-46
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  • [Title] Endobronchial intratumoral chemotherapy (EITC) followed by surgery in early non-small cell lung cancer with polypoid growth causing erroneous impression of advanced disease.
  • BACKGROUND: Seventeen patients with (M0) non-small cell lung cancer (NSCLC) without distant metastasis were treated by preoperative endobronchial intratumoral chemotherapy (EITC) followed by surgery.
  • Preoperative intratumoral chemotherapy was performed for the purpose of either reducing the extent of resection or increasing operability.
  • Clinically, in the preliminary diagnostic bronchoscopic examination, the tumor was located in the main stem bronchus closer than 2 cm to the carina [T3] in 12 patients, or at the level of carina or bulging towards the trachea [T4] in 5 patients.
  • THERAPEUTIC METHODS: EITC consisted of direct injection of a maximum dose of 40 mg cisplatin in aqueous solution (4 mg/ml) into the tumor through a flexible bronchoscope; administered four times: once a week during a 3-week period (on days 1, 8, 15 and 22).
  • Necrotic tumor debris was removed by piecemeal resection with forceps and suction at each session.
  • RESULTS: In all patients, the bulk of tumor in the main bronchus was eliminated by the end of 3 weeks of EITC treatment.
  • Post-EITC treatment bronchoscopy revealed that primary tumors originated in a lobe or segment without invasion of the mucous membrane of the major bronchus.
  • EITC treatment reduced the extent of tumor such that inoperable tumors became operable.
  • CONCLUSIONS: In this selected group of 17 patients, EITC was shown to be a safe, effective and easy to perform method for debulking of obstructed airways before surgery; without any important side effects or systemic drug toxicity.
  • Because this type of obstructive lung cancer may lead to inappropriate initial diagnosis, we suggest that obstructive lung cancer patients such as described here, with a potentially a very favorable prognosis, should be considered a distinct clinical entity perhaps best described as "Early NSC Lung Cancer with polypoid growth in a major airway causing the erroneous impression of advanced disease".
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy. Polyps / drug therapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / administration & dosage. Bronchoscopy. Cisplatin / administration & dosage. Combined Modality Therapy. Disease Progression. Female. Humans. Injections, Intralesional. Male. Middle Aged. Radiography, Thoracic. Survival Analysis. Treatment Outcome

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  • (PMID = 17045361.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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5. Kitai T, Nomura A, Miki A, Ukikusa M, Kojima N, Nishikawa S, Ishigaki T, Todo G: [Clinical benefit of bronchial arterial infusion chemotherapy to pulmonary metastasis from colorectal cancer--report of two cases]. Gan To Kagaku Ryoho; 2003 Dec;30(13):2125-8
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  • [Title] [Clinical benefit of bronchial arterial infusion chemotherapy to pulmonary metastasis from colorectal cancer--report of two cases].
  • Case 1: A 60-year-old woman with sigmoid colon cancer and multiple lung metastases developed dyspnea 34 months after sigmoidectomy and following systemic chemotherapy.
  • Chest X-ray revealed left atelectasis and obstruction of the left main bronchus by lung metastasis, and stenosis of the right main bronchus was also suspected.
  • The left bronchus remained patent for 12 months.
  • Case 2: A 70-year-old man who had a pulmonary recurrence of rectal cancer suffered from hemoptysis and dyspnea, which had improved with systemic chemotherapy but then become exacerbated again.
  • Bronchoscopic examination revealed intraluminal bleeding from a metastatic tumor.
  • The diameter of the treated tumor was reduced by 15%.
  • Bronchial arterial infusion chemotherapy for pulmonary metastasis from colorectal cancer is clinically beneficial, especially for patients with life-threatening respiratory symptoms like airway obstruction or intraluminal bleeding.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colorectal Neoplasms / pathology. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary
  • [MeSH-minor] Bronchial Arteries. Cisplatin / administration & dosage. Drug Administration Schedule. Dyspnea / etiology. Female. Fluorouracil / administration & dosage. Hemoptysis / etiology. Humans. Infusions, Intra-Arterial. Male. Middle Aged. Mitomycin / administration & dosage. Pulmonary Atelectasis / etiology. Sigmoid Neoplasms / pathology. Sigmoid Neoplasms / surgery

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  • (PMID = 14712776.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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6. Gika M, Takeuchi K, Takanami I: Successful management of a patient with stage IIIA non-small cell lung cancer using sensitivity-based induction chemotherapy--report of a case. Gan To Kagaku Ryoho; 2004 Nov;31(12):2055-8
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  • [Title] Successful management of a patient with stage IIIA non-small cell lung cancer using sensitivity-based induction chemotherapy--report of a case.
  • To select the most appropriate drug treatment for different patients with lung cancer, we have been measuring the chemosensitivity of lung cancer tissues to various drugs using the collagen gel droplet embedded culture drug sensitivity test (CD-DST).
  • A 57-year-old Japanese male with stage IIA squamous cell carcinoma of the lung received sensitivity-based induction chemotherapy consisting of docetaxel (70 mg/m2) given on days 1, 22, and 43.
  • After the chemotherapy, the left upper bronchus was reopened by the reduction of the tumor, and a left pneumonectomy with simultaneous partial resection of the pericardium was performed.
  • After discharge, the patient received 2 cycles of adjuvant chemotherapy, consisting of weekly docetaxel doses (35 mg/m2) for 3 consecutive weeks, followed by one week without treatment.
  • Although the 3-year survival rate of stage IIIA NSCLC patients is under 30%, three years after administration of the chemotherapy no other recurrence site has been detected, and the patient is in good health.
  • Using CD-DST, sensitivity-based induction chemotherapy with docetaxel was successful in the patient reported here.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy. Taxoids / therapeutic use
  • [MeSH-minor] Chemotherapy, Adjuvant. Drug Screening Assays, Antitumor. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 15570940.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel
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7. Hirasaki S, Suzuki S, Umemura S, Kamei H, Okuda M, Kudo K: Asymptomatic colonic metastases from primary squamous cell carcinoma of the lung with a positive fecal occult blood test. World J Gastroenterol; 2008 Sep 21;14(35):5481-3
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  • [Title] Asymptomatic colonic metastases from primary squamous cell carcinoma of the lung with a positive fecal occult blood test.
  • We describe a 74-year-old man with a colonic metastatic squamous cell carcinoma (SCC) from the lung.
  • Computed tomography (CT) of the chest demonstrated a large lung tumor in the right upper lobe obstructing the right upper bronchus.
  • Bronchoscopy revealed an easy-bleeding tumor in the right upper bronchus that was diagnosed as poorly differentiated squamous cell lung carcinoma.
  • The lesion was diagnosed as metastatic colonic SCC.
  • He underwent chemotherapy with an infusion of cisplatin 130 mg i.v. day 1, and docetaxel hydrate 100 mg i.v. day 1, repeated every 4 wk, followed by 4 courses of chemotherapy.
  • The primary lesion shrank by less than 10% and was judged to be "Partial Response" (PR) after 3 courses of treatment.
  • The patient still lived 23 wk after the diagnosis of metastatic colonic SCC.
  • Colonic metastasis of primary SCC of the lung is rare.
  • [MeSH-major] Carcinoma, Small Cell / secondary. Colonic Neoplasms / secondary. Lung Neoplasms

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  • (PMID = 18803365.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2744902
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8. Kojima T, Matsui T, Uemura T, Fujimitsu Y, Kure N, Mochizuki Y, Kojima H: [A case of recurrent gastroesophageal junction adenocarcinoma successfully treated with radiation plus chemotherapy (5-FU+CDDP, S-1, Paclitaxel, CPT-11) for long-term survival with good QOL]. Gan To Kagaku Ryoho; 2008 Nov;35(11):1923-6
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  • [Title] [A case of recurrent gastroesophageal junction adenocarcinoma successfully treated with radiation plus chemotherapy (5-FU+CDDP, S-1, Paclitaxel, CPT-11) for long-term survival with good QOL].
  • Chemoradiotherapy with S-1 followed by chemotherapy (S-1) was performed from January 2005 to April 2006.
  • Lymphnode metastasis to the left side of the main bronchus appeared in May 2006, and paclitaxel was used until December 2007 when PR was indicated by CT scan and GIF.
  • [MeSH-major] Camptothecin / analogs & derivatives. Cisplatin / therapeutic use. Neoplasms / drug therapy. Neoplasms / radiotherapy. Oxonic Acid / therapeutic use. Paclitaxel / therapeutic use. Quality of Life. Tegafur / therapeutic use
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Drug Combinations. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / pathology. Esophageal Neoplasms / radiotherapy. Esophageal Neoplasms / surgery. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology. Stomach Neoplasms / radiotherapy. Stomach Neoplasms / surgery. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 19011344.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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9. Lee TP, Tzao C, Liu JH, Yu CP, Hsu HH, Chien HN: Isolated endobronchial metastasis of Wilms' tumor. J Pediatr Surg; 2005 Sep;40(9):e33-5
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  • [Title] Isolated endobronchial metastasis of Wilms' tumor.
  • Isolated endobronchial metastasis from extrapulmonary solid organ was rarely reported in previous literature.
  • We report an isolated endobronchial metastasis of Wilms' tumor in a 4-year-old boy.
  • He underwent right nephrectomy on account of Wilms' tumor at the age of 3 years.
  • We performed a wedge resection of a metastasis to the right lower lobe of the lung a year later, followed by chemotherapy and irradiation of the involved lung over a period of 30 weeks.
  • One and a half years later, he developed obstructive pneumonitis of the left lung.
  • Fiberoptic bronchoscopy identified a tumor at the left main bronchus with near total bronchial obstruction, compatible with findings on a computed tomographic scan.
  • Rigid bronchoscopy was performed to core out the obstructing tumor.
  • It was reported as a metastatic Wilms' tumor.
  • Successful reexpansion of the left upper lobe was achieved and he was discharged uneventfully, followed by adjuvant chemotherapy.
  • [MeSH-major] Kidney Neoplasms / pathology. Lung Neoplasms / secondary. Wilms Tumor / secondary
  • [MeSH-minor] Bronchoscopy. Child, Preschool. Combined Modality Therapy. Humans. Male. Pneumonia / etiology

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  • (PMID = 16150331.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Fujisaki S, Takashina M, Tomita R, Takayama T, Ohmori K, Tomiyama J, Oyama K: [A case of resection of esophageal cancer infiltrating the left main bronchus following preoperative chemo-radiotherapy and resection of metachronous lung metastasis]. Gan To Kagaku Ryoho; 2007 Nov;34(12):1964-6
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  • [Title] [A case of resection of esophageal cancer infiltrating the left main bronchus following preoperative chemo-radiotherapy and resection of metachronous lung metastasis].
  • We herein report a case of T4 esophageal carcinoma, which was resected after chemo-radiation therapy.
  • In addition, the metachronous lung metastasis was also resected.
  • A 59-year-old female with esophageal carcinoma, which invaded the left main bronchus, underwent chemo-radiation therapy (the combination of systemic chemotherapy of 5-FU/CDDP and external radiation therapy) from January 2004.
  • After the therapy, although the imaging showed a downstaging of esophageal carcinoma, a severe esophageal stricture appeared with ingestion defective.
  • Nine months after esophagectomy, chest CT scan revealed that a solitary pulmonary tumor appeared in S6 of the right.
  • The solitary tumor enlarged gradually.
  • On August 2005, a surgical resection for the solitary pulmonary tumor was performed.
  • Histopathologically, the lesion was compatible for metastasis from esophageal carcinoma.
  • [MeSH-major] Bronchi / surgery. Esophageal Neoplasms / surgery. Lung Neoplasms / secondary. Lung Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 18219866.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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11. Fujisawa T, Aoshima M, Uchiyama N, Satoh T, Ohmagari N, Chonabayashi N, Saiki S, Suzuki K: [A case of mediastinal metastasis of renal small cell carcinoma, performing CHOP therapy for an acute respiratory failure by the air way obstruction under the mechanical ventilation]. Nihon Kokyuki Gakkai Zasshi; 2003 Jul;41(7):440-6
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  • [Title] [A case of mediastinal metastasis of renal small cell carcinoma, performing CHOP therapy for an acute respiratory failure by the air way obstruction under the mechanical ventilation].
  • A case of mediastinal metastasis of renal small cell carcinoma was reported.
  • Prior to pathological diagnosis, CHOP therapy with cyclophosphamide, adriamycin, vincristine and prednisolone was performed under mechanical ventilation for the purpose of resuscitation.
  • The therapy was effective; and the was weaned from the mechanical ventilator, resulting in complete remission.
  • Transbronchial samples from the left main bronchus confirmed that the mediastinal mass was identical pathologically to the renal small cell carcinoma (RSCC) resected 5 years before.
  • As a result, the mediastinal mass was diagnosed as a metastatic focus of RSCC.
  • Despite efforts with chemotherapy, almost all cases that appear in the literature died within 1 year after diagnosis.
  • No standard treatment modality has yet been established.
  • Thus, the present case is rare because an RSCC relapse after a long free period went into remission as a result of CHOP therapy.
  • It is suggested that CHOP therapy may well be an effective tool against RSCC, and could be a valuable choice for a treatment regimen.
  • [MeSH-major] Airway Obstruction / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Renal Cell / drug therapy. Kidney Neoplasms / drug therapy. Mediastinal Neoplasms / drug therapy. Respiration, Artificial. Respiratory Insufficiency / therapy

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  • (PMID = 12931670.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
  • [Number-of-references] 17
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12. Brunetti G, Delmastro M, Poggi G, Avanza F, Bertoli G: Sudden improvement of respiratory failure in a woman with carcinoma of the colon. Monaldi Arch Chest Dis; 2002 Feb;57(1):35-8
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  • We present a case of bronchial and endotracheal metastases completely blocking the left main bronchus and partially occluding the middle lobe bronchus contributing to severe respiratory failure.
  • The patient's lack of consent to laser resection of the mass led to the use of chemotherapy; after the first cycle of treatment a neoplastic mass about 3 cm long was spontaneously expelled with a cough.
  • The expulsion of the metastasis caused rapid improvement of the dyspnea and gas exchange; however, the continuation of the chemotherapy did not bring any further benefit to the patient, who died 115 days after diagnosis.

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  • (PMID = 12174701.001).
  • [ISSN] 1122-0643
  • [Journal-full-title] Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
  • [ISO-abbreviation] Monaldi Arch Chest Dis
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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13. Schmidbauer S, Ladurner R, Jückstock H, Trupka AW, Mussack T, Hallfeldt KK: [Surgical and adjuvant therapy of neuroendocrine tumors of the gastrointestinal tract and their metastases. A retrospective analysis of personal patient group]. Chirurg; 2001 Aug;72(8):945-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical and adjuvant therapy of neuroendocrine tumors of the gastrointestinal tract and their metastases. A retrospective analysis of personal patient group].
  • [Transliterated title] Die operative und adjuvante Therapie neuroendokriner Tumoren des Gastrointestinaltrakts und ihrer Metastasen. Eine retrospektive Analyse des eigenen Patientenguts.
  • Surgical treatment and prognosis depend on the location of the tumor.
  • RESULTS AND CONCLUSIONS: The most frequent primary sites were the ileum and jejunum (36%), appendix (36%), stomach (12%), pancreas (8%), colon (4%) and bronchus with hepatic metastasis (4%).
  • A malignant carcinoid syndrome was present in 8 patients.
  • In patients with neuroendocrine tumors, curative, radical tumor removal should be attempted.
  • Some patients with advanced disease needed some surgery for tumor debulking and resection of metastases.
  • In non-resectable liver metastases hepatic arterial chemotherapy and chemoembolization after implantation of port catheters seem to be very beneficial therapeutic options.
  • A fixed part of the therapeutic regime in progressive disease is adjuvant chemotherapy with 5-fluorouracil and streptozotocin and symptomatic therapy with octreotide.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Gastrointestinal Neoplasms / surgery. Liver Neoplasms / secondary. Neuroendocrine Tumors / secondary
  • [MeSH-minor] Adult. Aged. Chemoembolization, Therapeutic. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Follow-Up Studies. Humans. Male. Malignant Carcinoid Syndrome / drug therapy. Malignant Carcinoid Syndrome / surgery. Middle Aged. Octreotide / administration & dosage. Octreotide / adverse effects. Retrospective Studies. Streptozocin / administration & dosage. Streptozocin / adverse effects. Treatment Outcome

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  • (PMID = 11554141.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5W494URQ81 / Streptozocin; RWM8CCW8GP / Octreotide; U3P01618RT / Fluorouracil
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14. Suzuki M, Kadoyama C, Otsuji M, Sugiura T, Kimura F, Suwa T, Fujisawa T: Long-term survival achieved by resection of metastases in the liver and lung in a patient with recurrent colonic cancer: report of a case. Surg Today; 2000;30(11):1037-40
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  • [Title] Long-term survival achieved by resection of metastases in the liver and lung in a patient with recurrent colonic cancer: report of a case.
  • A lateral segmentectomy was performed for a solitary hepatic metastasis, and partial resection of right S1 was later carried out for a pulmonary metastasis.
  • Another pulmonary metastasis was found 6 years after his third operation and to minimize the area to be resected, bronchial arterial infusion chemotherapy was performed twice.
  • A 51% reduction in the size of the tumor was achieved, so a right upper lobectomy and wedge resection of the bronchus were performed.
  • This case is considered noteworthy because it demonstrates the potential effectiveness of local adjuvant chemotherapy and the possibility of extended survival in a patient who has undergone resection of both hepatic and pulmonary metastases from colonic cancer.
  • [MeSH-major] Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Humans. Male. Middle Aged

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  • (PMID = 11110404.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
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15. Scott WJ, Howington J, Movsas B, American College of Chest Physicians: Treatment of stage II non-small cell lung cancer. Chest; 2003 Jan;123(1 Suppl):188S-201S
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  • [Title] Treatment of stage II non-small cell lung cancer.
  • Based on clinical assessment alone, patients with stage II non-small cell lung cancer (NSCLC) comprise only 5% of all patients with NSCLC.
  • By definition, patients with tumor invading the chest wall apex, mediastinum, diaphragm, or even the mainstem bronchus may all have T3 tumors.
  • The extent of the data available regarding treatment of each of these different groups is therefore limited.
  • Studies of adjuvant therapy after complete resection of stage II NSCLC are an important exception to this generalization, since data from large, randomized studies of adjuvant radiation therapy, chemotherapy, or a combination of the two are available for analysis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery. Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy / methods. Humans. Lymphatic Metastasis. Neoplasm Staging. Pneumonectomy / methods. Radiotherapy, Adjuvant. Survival Analysis


16. Bernard A, Ferrand L, Hagry O, Benoit L, Cheynel N, Favre JP: Identification of prognostic factors determining risk groups for lung resection. Ann Thorac Surg; 2000 Oct;70(4):1161-7
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  • [Title] Identification of prognostic factors determining risk groups for lung resection.
  • METHODS: In a prospective study 500 patients undergoing lung resection (wedge resection, n = 141; lobectomies, n = 245; bilobectomies, n = 12; and pneumonectomies, n = 102) were included.
  • Sleeve resection of the bronchus to preserve lung parenchyma was performed in 22 patients.
  • Factors adversely affecting postoperative complications by multivariate analysis included pulmonary pathology, bronchoplastic technique, forced expiratory volume in 1 second (FEV1), extended resection, type of lung resection, comorbidity indices, and preoperative chemotherapy.
  • Risk group I (n = 60) with the best prognosis included patients with FEV1 greater than or equal to 80% undergoing wedge resection for a benign lesion or metastasis.
  • Risk group II (n = 161) included patients with FEV1 greater than or equal to 80% undergoing major pulmonary resection for a benign lesion or metastasis or lung cancer, or patients with FEV1 less than 80% undergoing wedge resection for benign lesion or metastasis.
  • Risk group III (n = 233) with a fair prognosis included patients with comorbidity indices less than 4 and FEV1 greater than or equal to 80% undergoing extended pulmonary resection for a benign lesion or metastasis or lung cancer, or patients with FEV1 less than 80% and emphysema.
  • Risk group IV (n = 46) with the worst prognosis included patients with FEV1 less than 80% undergoing an extended lung resection or bronchoplastic procedures for a benign lesion or metastasis or lung cancer, or patients with comorbidity indices greater than or equal to 4 undergoing extended lung resection for lung cancer.
  • CONCLUSIONS: In a prospective study, based on these prognostic factors, a practical, easy-to-use risk group system of lung resection is proposed as a tool to aid the decision to perform lung resection.
  • [MeSH-major] Lung Diseases / surgery. Lung Neoplasms / surgery. Pneumonectomy. Postoperative Complications / mortality

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  • (PMID = 11081862.001).
  • [ISSN] 0003-4975
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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17. Mehta JS, Abou-Rayyah Y, Rose GE: Orbital carcinoid metastases. Ophthalmology; 2006 Mar;113(3):466-72
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  • OBJECTIVE: To describe a series of patients with metastatic orbital carcinoid tumors.
  • Records were evaluated for age at presentation, race, gender, laterality, visual function and clinical features, site of orbital metastasis, treatment, and outcome.
  • The site of the primary tumor, presence of systemic symptoms, diagnosis and treatment of the primary tumor, and current survival status were also noted.
  • MAIN OUTCOME MEASURES: Time from tumor to death.
  • RESULTS: Thirteen patients (9 male) had an average age at biopsy-proven diagnosis of 65.3 years.
  • The primary tumor was ileal in 7, colonic in 4, and from bronchus and breast (1 each); in 9 patients, the primary tumor was already known.
  • Six patients underwent a meta-iodobenzyl guanidine/octreotide scan and metastatic disease was found in 4.
  • Four patients underwent exenteration, 5 had radiotherapy after tumor debulking, 2 had radiotherapy alone, and 2 patients had local radiotherapy with receptor-targeted chemotherapy.
  • Seven patients died from metastatic tumor.
  • [MeSH-major] Carcinoid Tumor / secondary. Carcinoid Tumor / therapy. Orbital Neoplasms / secondary. Orbital Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / pathology. Bronchial Neoplasms / pathology. Chemotherapy, Adjuvant. Colonic Neoplasms / pathology. Female. Humans. Ileal Neoplasms / pathology. Male. Retrospective Studies. Survival Analysis

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  • (PMID = 16458966.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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18. Saito M, Furukawa K, Miura T, Kato H: Evaluation of T factor, surgical method, and prognostic factors in central type lung cancer. Jpn J Thorac Cardiovasc Surg; 2002 Oct;50(10):413-7
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  • [Title] Evaluation of T factor, surgical method, and prognostic factors in central type lung cancer.
  • OBJECTIVE: We report our experience in the diagnosis and surgical treatment of central type lung cancer (CTLC) and discuss the prognostic significance of clinicopathological factors including the T factor.
  • Data on CTLC was compared to that on peripheral lung cancer during the same period.
  • RESULTS: Compared to peripheral tumors, central lung tumors showed a higher ratio in male gender, pN1 in pN factors, squamous cell carcinoma in histology, and pneumonectomy and bronchoplasty in surgery.
  • No significant difference was seen in 5-year survival based on 8 factors--period, cT factors, tumor histology, bronchoplasty, extended surgery, cellular atypia, additional chemotherapy, and radiotherapy.
  • Five-year survival differed significantly for 12 other factors--pT, cN, and pN factors; surgical method; number of resected organs in extended surgery; curability (complete/incomplete); tumor size; N1 and N2 station metastasis; p factor, and blood vessel and lymphatic invasion.
  • CONCLUSIONS: CTLC appears to belong to a subgroup other than peripheral tumors, requiring a more accurate diagnosis of cT factors, particularly in the proximal bronchus, because cT and cN factors are the only 2 used preoperatively.
  • [MeSH-major] Lung Neoplasms / surgery

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  • (PMID = 12428380.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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19. Stoelben E, Digel W, Henke M, Passlick B: [Multimodal treatment of non small cell lung cancer]. Zentralbl Chir; 2006 Apr;131(2):110-4
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  • [Title] [Multimodal treatment of non small cell lung cancer].
  • [Transliterated title] Multimodale Therapie des nichtkleinzelligen Bronchialkarzinoms.
  • The primary treatment of lung cancer depends on tumor stage.
  • In case of lung cancer without mediastinal lymph node enlargement or direct mediastinal involvement (clinical stage I-IIb + T3N1) surgical treatment is recommended.
  • The use of adjuvant chemotherapy has to be defined, but will be indicated in stage II and IIIa.
  • Expected 5-year survival achieves 40 to 80 % depending on tumor stage.
  • In case of N2-disease and after tumor response to preoperative chemotherapy (about 60 %) secondary resection of the tumor leads to higher 5-year survival rates (20-40 %) compared to patients without induction therapy (5-20 %).
  • In these patients and after unexpected detection of solitary lymph node metastasis by primary resection adjuvant mediastinal radiotherapy should be added.
  • If the tumor has infiltrated the mediastinum or the upper sulcus (T3/4) and/or mediastinal lymph nodes are obviously tumor burden (e. g. > 3 cm, N2 bulky, N3) radical primary resection may not be possible.
  • In these patients combined radio- and chemotherapy induces a high percentage of tumor regression and can be used before secondary resection (5-year survival 5-20 %).
  • Locally advanced tumors infiltrating the main bronchus close to the carina or the carina itself and tumors with metastases in the same lobe, both without mediastinal lymph node metastases (T3/4N0-1), can be resected by sleeve pneumonectomy and lobectomy with satisfactory results respectively.
  • In patients with resectable lung cancer and no clinical sign of tumor disease (f. e. anemia, weight loss, pain) limited staging procedure with chest CT scan including upper abdomen and bronchoscopy is reasonable.
  • We recommend an interdisciplinary approach to patients with lung cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Bronchogenic / surgery. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery. Neoadjuvant Therapy. Pneumonectomy
  • [MeSH-minor] Bronchoscopy. Chemotherapy, Adjuvant. Combined Modality Therapy. Humans. Lymph Node Excision. Mediastinoscopy. Neoplasm Staging. Palliative Care. Radiotherapy, Adjuvant. Software Design. Tomography, X-Ray Computed

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  • (PMID = 16612776.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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20. Bagan P, Berna P, Pereira JC, Le Pimpec Barthes F, Foucault C, Dujon A, Riquet M: Sleeve lobectomy versus pneumonectomy: tumor characteristics and comparative analysis of feasibility and results. Ann Thorac Surg; 2005 Dec;80(6):2046-50
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  • [Title] Sleeve lobectomy versus pneumonectomy: tumor characteristics and comparative analysis of feasibility and results.
  • METHODS: From 1984 to 2002, 973 lung resections were performed for T1, T2, and bronchial T3 right upper lobe non-small cell lung cancer.
  • Pneumonectomy 1 (RP1) was a group of N0, intralobar N1, and skip metastasis involvement (N0-N2).
  • Pneumonectomy 2 (RP2) was a group of extralobar N1 and nonskip metastasis involvement (N1-N2).
  • Significant factors limiting SL were tumor size, extralobar N1, and main bronchus involvement (p = 0.000026, 0.0002, and 0.005, respectively).
  • For frequency to increase by systematic attempt at SL, limited by large tumors and extralobar N1 involvement, the only way should be after favorable response to induction chemotherapy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery. Pneumonectomy / methods

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  • (PMID = 16305842.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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21. Teschner M, Durisin M, Mangold A, Lenarz T, Stöver T: [Peripheral facial palsy as the first symptom of a metastatic bronchogenic carcinoma]. Laryngorhinootologie; 2006 Jul;85(7):512-6
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  • [Title] [Peripheral facial palsy as the first symptom of a metastatic bronchogenic carcinoma].
  • A 10-day rheologic therapy as well as anti-viral medication were not successful.
  • Five days after rheological therapy had been completed, the patient presented a swelling of the neck.
  • In the computer tomography we found a bilateral thrombosis of the internal jugular vein.
  • The following thorax CT as well as the diagnostic extirpation of an enlarged cervical lymph node lead to the diagnosis of a metastasized smallcell neuro-endocrine bronchogenic carcinoma with a compression of the right primary bronchus and the vena cava superior as well as an upper inflow congestion.
  • In the cMRT we furthermore found a metastasis in the area of the foramen stylomastoideum.
  • The patient underwent emergency radiation and chemotherapy.
  • RESULTS: According to the present findings, this metastasis lead to the facial palsy as the initial symptom of the bronchogenic carcinoma.
  • CONCLUSION: Therefore, therapy resistant facial palsy should be further diagnosed in detail, especially examined by imaging procedures.
  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma, Bronchogenic. Facial Paralysis / etiology. Lung Neoplasms. Skull Neoplasms / secondary. Temporal Bone
  • [MeSH-minor] Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / mortality. Cerebellar Neoplasms / secondary. Cerebellar Neoplasms / therapy. Combined Modality Therapy. Glossopharyngeal Nerve Diseases / diagnosis. Glossopharyngeal Nerve Diseases / etiology. Humans. Jugular Veins. Magnetic Resonance Imaging. Male. Middle Aged. Paralysis / diagnosis. Paralysis / etiology. Prognosis. Radiography, Thoracic. Time Factors. Tomography, X-Ray Computed. Venous Thrombosis / radiography

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  • (PMID = 16791767.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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