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Items 1 to 29 of about 29
1. Mizutani K, Seike K, Sugawara T, Masue T, Yokoi S, Ehara H, Takahashi Y, Ishihara S, Deguchi T: [Multiple metastases of the penile cancer: an experience of combination chemotherapy]. Hinyokika Kiyo; 2004 Mar;50(3):223-6
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  • [Title] [Multiple metastases of the penile cancer: an experience of combination chemotherapy].
  • A 49-year-old man with penile cancer (cT3N1M0) was referred to our hospital.
  • The pathologic diagnosis was squamous cell carcinoma.
  • The patient underwent penectomy and bilateral inguinal lymphadenectomy without postoperative adjuvant therapy.
  • Six months later, we found multiple metastases of the penile cancer in the lungs.
  • The patient was then treated with combination chemotherapy of cisplatin, methotrexate, bleomycin.
  • However, the tumors were aggressive and did not respond to the therapy.
  • We discuss the use of combination chemotherapy in the case of advanced penile cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / secondary. Lymph Nodes / pathology. Neoplastic Cells, Circulating / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Bleomycin / administration & dosage. Bone Neoplasms / secondary. Cisplatin / administration & dosage. Drug Administration Schedule. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Male. Methotrexate / administration & dosage. Middle Aged. Penis / surgery

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  • (PMID = 15148780.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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2. Küronya Z, Bodrogi I, Lövey J, Plótár V, Manninger S, Pápai Z: [Metachronous metastasis from rectal adenocarcinoma to the penis--case report]. Magy Onkol; 2009 Sep;53(3):263-6
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  • [Title] [Metachronous metastasis from rectal adenocarcinoma to the penis--case report].
  • Despite of its rich vascularization and extensive circulatory communication with neighboring organs, penile metastases are rare.
  • Even more infrequent is a penile metastasis of rectum tumors.
  • Since the first report of rectal carcinoma with metastasis to the penis (Ehbert 1870), approximately 50 cases have been reported, most of them from the USA, the remaining from Western Europe, the Middle East and Japan.
  • The first Hungarian case is reported now of penile metastasis of a rectal carcinoma.
  • The case of a 65-year-old man is presented: isolated penile metastasis discovered 4.5 years after the primary rectal cancer resection.
  • IHC tissue diagnosis and detailed clinical investigations confirmed metastatic rectal adenocarcinoma.
  • As our patient refused penectomy and KRAS mutation was proven, FOLFIRI chemotherapy was initiated without cetuximab.
  • The size and the number of penile metastases have not shown significant changes.
  • According to the literature the average survival of patients with penile metastases treated with radiochemotherapy is 8 months.
  • [MeSH-major] Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasms, Second Primary / diagnosis. Palliative Care / methods. Penile Neoplasms / secondary. Rectal Neoplasms / pathology
  • [MeSH-minor] Aged. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cetuximab. Chemotherapy, Adjuvant. Diagnosis, Differential. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / drug therapy. Organoplatinum Compounds / administration & dosage. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 19793691.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; PQX0D8J21J / Cetuximab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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3. Tsukamoto T, Yonese J, Kin T, Samejima T, Hasegawa Y, Fukui I, Ishikawa Y: [Carcinoma in situ of the penis rapidly progressing after carbon dioxide laser treatment]. Nihon Hinyokika Gakkai Zasshi; 2002 Mar;93(3):483-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Carcinoma in situ of the penis rapidly progressing after carbon dioxide laser treatment].
  • Laser treatment is considered to be effective in treating carcinoma in situ of the penis.
  • We, however, report a case with carcinoma in situ of the penis which developed invasive carcinoma and inguinal lymphnode metastases only 6 months after the laser treatment.
  • A 74-year-old man with pseudophimosis presented with redness of the glans penis.
  • No metastasis was suspected by physical examination and imaging studies.
  • Six months after the treatment, however, local recurrence was confirmed by the touch smear cytology, resulting in the partial amputation of the penis.
  • The histopathological examination revealed subepithelial and marked lymphatic invasion of the tumor and positive margin in the urethral stump (squamous cell carcinoma in situ).
  • Further, since bilateral superficial inguinal lymphnode swelling appeared, total amputation of the penis with perineal urethrotomy and pelvic/inguinal lymphnode dissection was performed subsequently.
  • The metastases to bilateral inguinal lymphnodes were confirmed histologically.
  • The patient received adjuvant chemotherapy and has been alive and well without evidence of disease 40 months after the initial treatment.
  • [MeSH-major] Carcinoma in Situ / pathology. Lasers / adverse effects. Penile Neoplasms / pathology
  • [MeSH-minor] Aged. Disease Progression. Humans. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local

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  • (PMID = 11968805.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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4. Sheen MC, Sheu HM, Jang MY, Chai CY, Wang YW, Wu CF: Advanced penile verrucous carcinoma treated with intra-aortic infusion chemotherapy. J Urol; 2010 May;183(5):1830-5
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  • [Title] Advanced penile verrucous carcinoma treated with intra-aortic infusion chemotherapy.
  • PURPOSE: Traditional treatment for advanced penile verrucous carcinoma is penectomy.
  • To preserve the penis we used intra-aortic infusion chemotherapy for advanced verrucous carcinoma.
  • MATERIALS AND METHODS: From 1991 to 2009 we treated 6 men with penile verrucous carcinoma with continuous intra-aortic infusion of 50 mg methotrexate every 24 hours (average 550 mg, range 400 to 800).
  • After continuous methotrexate infusion no further anticancer drug was given to complete responders.
  • RESULTS: After treatment 4 patients achieved a complete response and were disease-free 3 years 9 months to 17 years 10 months (median 11 years 3 months) after therapy.
  • The patient with a shaft tumor subsequently underwent total penectomy due to unbearable penile pain 4 years after infusion with various drugs without an appreciable response.
  • He has survived 12 years 5 months after initial treatment.
  • The other patient with glans and prepuce tumors had progression with bilateral inguinal metastases despite 1 1/2 years of infusion therapy.
  • CONCLUSIONS: Intra-aortic infusion chemotherapy is a simple, effective method to treat penile verrucous carcinoma with the uniqueness of preserving the anatomical structure and sexual function in complete responders.
  • For penile verrucous carcinoma, especially in younger patients, intra-aortic infusion chemotherapy may be considered organ sparing treatment before penectomy.
  • [MeSH-major] Antimetabolites, Antineoplastic / administration & dosage. Aorta, Abdominal. Carcinoma, Verrucous / drug therapy. Infusions, Intra-Arterial / methods. Methotrexate / administration & dosage
  • [MeSH-minor] Adult. Aged. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Male. Middle Aged. Mitomycin / administration & dosage. Penile Neoplasms / drug therapy. Treatment Outcome. Vitamin B Complex / administration & dosage

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  • [Copyright] 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] J Urol. 2010 May;183(5):1835 [20303106.001]
  • (PMID = 20303107.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 12001-76-2 / Vitamin B Complex; 50SG953SK6 / Mitomycin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; YL5FZ2Y5U1 / Methotrexate
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5. Sawada A, Segawa T, Nakanishi S, Kinoshita H, Yamamoto S, Kamoto T, Ogawa O: [Prostate cancer with penile metastasis: a case report]. Hinyokika Kiyo; 2005 Nov;51(11):771-3
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  • [Title] [Prostate cancer with penile metastasis: a case report].
  • A 77-year-old man presented with complaints of dysuria, nocturia and painless nodule on his penis.
  • Pathological examinations on prostate and penile biopsy specimens revealed prostate adenocarcinoma with penile metastasis.
  • The patient was diagnosed as having prostate cancer stage D2 (T4N1M1) with bone, lymph node and penile metastases.
  • There was no response to initial hormonal therapy with the surgical castration and diethylstilbestrol.
  • However, decrease of the tumor size, as well as PSA and CA19-9 values were achieved after the combined chemotherapy with Estramustine, Paclitaxel and Carboplatin.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Carboplatin / administration & dosage. Combined Modality Therapy. Estramustine / administration & dosage. Humans. Male. Orchiectomy. Paclitaxel / administration & dosage. Prostate-Specific Antigen / blood

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  • (PMID = 16363713.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 35LT29625A / Estramustine; BG3F62OND5 / Carboplatin; EC 3.4.21.77 / Prostate-Specific Antigen; P88XT4IS4D / Paclitaxel
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6. Hori J, Kato Y, Iwata T, Taniguchi N, Hashimoto H, Yachiku S: [A case of penile malignant melanoma]. Hinyokika Kiyo; 2003 Aug;49(8):493-6
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  • [Title] [A case of penile malignant melanoma].
  • In January, 2001, with complaints of black nodules and bleeding from the glans of the penis to the foreskin.
  • Clinical diagnosis was penile malignant melanoma.
  • Cystoscopy and urethrography revealed urethral invasion of malignant melanoma, and magnetic resonance imaging (MRI) of the penis revealed invasion to prostate, and pelvic lymph node metastases in abdominal compuled tomography (CT) but no organ metastases.
  • The pathological findings were nodular malignant melanoma, pT4bN2bM1a, and the surgical margin was positive.
  • After these therapies, chemotherapy was performed.
  • Five months later, CT revealed multiple lung and brain metastases, and radiation therapy and chemotherapy were performed.
  • Review of the literature revealed that our patient is the thirtieth reported case of penile malignant melanoma in Japan since 1924.
  • [MeSH-major] Melanoma / secondary. Penile Neoplasms / pathology. Urethral Neoplasms / pathology
  • [MeSH-minor] Aged. Combined Modality Therapy. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Prostatic Neoplasms / pathology

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  • (PMID = 14518390.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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7. Kim B, Garcia F, Touma N, Moussa M, Izawa JI: A rare case of penile cancer in situ metastasizing to lymph nodes. Can Urol Assoc J; 2007 Nov;1(4):404-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of penile cancer in situ metastasizing to lymph nodes.
  • Penile carcinoma in situ, or Queyrat's erythroplasia, is a rare condition of the glans penis.
  • This lesion has been associated with invasive squamous cell carcinoma; however, metastasis without an invasive component is extremely rare.
  • There have only been 2 documented cases with metachronous metastases.
  • We report a third case in which metastases were diagnosed at presentation.
  • The patient was a 51-year-old man who presented with a glans penile lesion and bilateral inguinal masses later determined to be carcinoma in situ with metastases to the inguinal and pelvic lymph nodes.
  • He subsequently underwent a partial penectomy and lymphadenectomy followed by adjuvant chemotherapy and radiation.
  • This case is discussed, along with a brief review of the literature.

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  • [Cites] Nat Rev Cancer. 2003 Jun;3(6):453-8 [12778135.001]
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  • (PMID = 18542829.001).
  • [ISSN] 1911-6470
  • [Journal-full-title] Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • [ISO-abbreviation] Can Urol Assoc J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2422981
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8. Uphoff J, Woziwodzki J, Schattka SO, Kollias A: [Loss of differentiation of a prostate adenocarcinoma after hormone therapy: the example of a metastasis in the spongy body of the penis]. Aktuelle Urol; 2008 Sep;39(5):373-7
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  • [Title] [Loss of differentiation of a prostate adenocarcinoma after hormone therapy: the example of a metastasis in the spongy body of the penis].
  • [Transliterated title] Differenzierungsverlust eines Adenokarzinoms der Prostata nach Hormontherapie: am Beispiel einer Schwellkörpermetastase des Penis.
  • Penile metastases are very uncommon.
  • Metastases in the penis only occur at an advanced state of the tumour and with a high dedifferentiation, e. g., ductal adenocarcinoma.
  • Often prior to the transformation an anti-androgen therapy has been undertaken.
  • At this state of the disease, there is only the possibility of a palliative therapy with a poor prognosis.
  • The increasing histological dedifferentiation of the tumour tissue can make it difficult or even impossible to identify the primary lesion.
  • [MeSH-major] Adenocarcinoma / secondary. Androgen Antagonists / therapeutic use. Antineoplastic Agents, Hormonal / therapeutic use. Carcinoma, Basal Cell / secondary. Carcinoma, Transitional Cell / secondary. Cell Transformation, Neoplastic / pathology. Diphosphonates / therapeutic use. Gonadotropin-Releasing Hormone / antagonists & inhibitors. Neoplasms, Multiple Primary / drug therapy. Penile Neoplasms / secondary. Prostatic Neoplasms / drug therapy
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Bone Neoplasms / drug therapy. Bone Neoplasms / pathology. Bone Neoplasms / secondary. Bone Neoplasms / surgery. Combined Modality Therapy. Cystectomy. Diagnosis, Differential. Disease Progression. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Penis / pathology. Penis / surgery. Prostate / pathology. Prostate / surgery. Prostatectomy

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  • (PMID = 18798127.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Androgen Antagonists; 0 / Antineoplastic Agents, Hormonal; 0 / Biomarkers, Tumor; 0 / Diphosphonates; 33515-09-2 / Gonadotropin-Releasing Hormone
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9. Ketata S, Boulaire JL, Soulimane B, Bargain A: Metachronous metastasis to the penis from a rectal adenocarcinoma. Clin Colorectal Cancer; 2007 Sep;6(9):657-9
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  • [Title] Metachronous metastasis to the penis from a rectal adenocarcinoma.
  • Penile metastases arise most frequently from genitourinary cancers, but can also arise from tumors of the large bowel; other primary sites are extremely uncommon.
  • We report the case of a 59-year-old patient with 2 penile metastases from a rectal adenocarcinoma, which was discovered 26 years after abdominoperineal resection.
  • Penile biopsy was carried out and established the metastatic nature.
  • The patient underwent palliative chemotherapy treatment with cetuximab/irinotecan.
  • All previously reported cases of penile metastasis from the rectum are reviewed.
  • Regardless of the treatment options, the prognosis of such metastasis remains poor.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Rectal Neoplasms / pathology
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cetuximab. Humans. Immunohistochemistry. Male. Middle Aged. Palliative Care. Prognosis

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  • (PMID = 17945039.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 7673326042 / irinotecan; PQX0D8J21J / Cetuximab; XT3Z54Z28A / Camptothecin
  • [Number-of-references] 18
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10. Feng T, Yohannan J, Allaf ME: Nonseminomatous germ cell tumor of the testes metastatic to the corpus cavernosum of the penis. Urology; 2010 Feb;75(2):255-6
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  • [Title] Nonseminomatous germ cell tumor of the testes metastatic to the corpus cavernosum of the penis.
  • Metastases to the penis are rare, with less than 200 cases reported.
  • These cases typically represent widely disseminated disease and are associated with a poor prognosis.
  • We present images of a case of a testicular nonseminomatous mixed germ cell tumor, which metastasized to the corpus cavernosum of the penis 8 months after a negative bilateral retroperitoneal lymph node dissection.
  • The patient received chemotherapy and experienced a complete response.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / secondary. Penile Neoplasms / secondary. Testicular Neoplasms / pathology

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  • [Copyright] 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19931126.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Thyavihally YB, Tongaonkar HB, Gupta S, Gujral S: Primary seminal vesicle adenocarcinoma presenting as isolated metastasis to penis responding to chemotherapy and hormonal therapy. Urology; 2007 Apr;69(4):778.e1-3
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  • [Title] Primary seminal vesicle adenocarcinoma presenting as isolated metastasis to penis responding to chemotherapy and hormonal therapy.
  • We report a rare case of isolated penile metastasis from seminal vesicle adenocarcinoma associated with ipsilateral renal agenesis in a 62-year-old man.
  • The sigmoidoscopy and metastatic workup findings were normal.
  • The patient received six cycles of 5-fluorouracil, leucovorin, and oxaliplatin chemotherapy and underwent bilateral orchiectomy.
  • The patient was symptomatically better, and the penile swelling and seminal vesicle mass had regressed considerably.
  • He later developed multiple lung metastases and died of the disease.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Antineoplastic Agents / therapeutic use. Orchiectomy. Penile Neoplasms / secondary. Penile Neoplasms / therapy. Seminal Vesicles
  • [MeSH-minor] Combined Modality Therapy. Genital Neoplasms, Male / pathology. Humans. Male. Middle Aged

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  • (PMID = 17445672.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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12. Zheng FF, Zhang ZY, Dai YP, Liang YY, Deng CH, Tao Y: Metastasis to the penis in a patient with adenocarcinoma of lung, case report and literature review. Med Oncol; 2009;26(2):228-32
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  • [Title] Metastasis to the penis in a patient with adenocarcinoma of lung, case report and literature review.
  • Metastasis of lung cancer to the penis is very rare; it causes various clinical symptoms seriously affecting the quality of life.
  • Here, we report a case of penile metastasis secondary to pulmonary carcinoma along with a review of the literature.
  • One case of penile metastasis secondary to pulmonary carcinoma was detected in a 51-year-old patient who was admitted to the First Affiliated Hospital of Sun Yat-Sen University with persistent cough along with swelling of the perineum and penis.
  • The clinical features, diagnosis, and treatment of this disease along with a relevant literature are reviewed and discussed.
  • CT scan revealed lung mass, and a glans penis ulcer and enlargement of inguinal lymph nodes was discovered upon physical examination.
  • CT-guided percutaneous puncture of the lung mass revealed adenocarcinoma of lung, and biopsies of the glans penis ulcer and inguinal lymph nodes confirmed metastatic adenocarcinoma.
  • The patients received chemotherapy and died of acute pulmonary embolism in less than 2 months.
  • Metastasis of lung cancer to the penis is extremely rare.
  • Although treatment of penile metastasis is almost always palliative, early recognition may enhance survival for these patients.
  • [MeSH-major] Adenocarcinoma / pathology. Lung Neoplasms / pathology. Penile Neoplasms / secondary

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  • (PMID = 18975150.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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13. Hakenberg OW, Franke HJ, Froehner M, Wirth MP: The treatment of primary urethral carcinoma--the dilemmas of a rare condition: experience with partial urethrectomy and adjuvant chemotherapy. Onkologie; 2001 Feb;24(1):48-52
Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The treatment of primary urethral carcinoma--the dilemmas of a rare condition: experience with partial urethrectomy and adjuvant chemotherapy.
  • Treatment will therefore have to follow rules established for the treatment of similar conditions.
  • In 3 male cases, a primary urothelial carcinoma of the distal urethra was treated by distal urethrectomy only.
  • In 3 other cases with locally advanced tumors and/or lymph node metastases surgical treatment was followed by adjuvant cisplatinum-containing chemotherapy.
  • RESULTS: In the 3 cases with distal urethral carcinoma, partial urethrectomy with preservation of the penis resulted in cure, with a follow-up of 12-71 months.
  • In the cases with advanced disease, adjuvant chemotherapy after surgery has resulted in complete remissions in all 3 cases, with a follow-up of 4-47 months at present.
  • CONCLUSIONS: In localized, noninvasive carcinoma of the distal male urethra, partial urethrectomy seems adequate and the avoidance of penile amputation justified.
  • In advanced cases, after local excision and lymphadenectomy adjuvant chemotherapy which by necessity must follow the guidelines established for the treatment of other urothelial or squamous cell malignancies seems to be beneficial.
  • [MeSH-minor] Adult. Biopsy. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Urethra / pathology. Urethra / surgery

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  • [Copyright] Copyright 2001 S. Karger GmbH, Freiburg
  • (PMID = 11441281.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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14. van der Merwe A, Zarrabi A, Basson J, Stander J, Heyns CF: Distant cutaneous metastases secondary to squamous carcinoma of the penis. Can J Urol; 2009 Feb;16(1):4498-501; discussion 4501
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  • [Title] Distant cutaneous metastases secondary to squamous carcinoma of the penis.
  • Penile cancer normally spreads in a predictable manner to the regional lymph nodes: first inguinal and then the pelvic nodes.
  • We report a case where the patient presented synchronously with secondary skin metastases and primary high grade penile squamous carcinoma.
  • In addition the patient also had pulmonary metastases, loco regional spread to the groin nodes, liver metastases and tumour erosion of a right sided rib.
  • The skin metastases appeared nodular, were firm in consistency and appeared intradermal.
  • Skin metastases have been described for a number of solid malignancies - the clinician must have an index of suspicion to relate a less obvious primary lesion with secondary skin lesions.
  • The patient died before chemotherapy could be administered.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Penile Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 19222890.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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15. Matuszewska K, Matuszewski M, Kowalczyk A, Jassem J: Penile metastases from urogenital primaries. Neoplasma; 2002;49(5):346-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile metastases from urogenital primaries.
  • Metastatic tumors of the penis are rare.
  • They are usually secondary to primaries of the genitourinary and gastrointestinal tracts.
  • This entity is usually accompanied by distressing symptoms like dysuria, pain, induration, swelling of the penis and priapism, making immediate intervention necessary.
  • Different methods of treatment are used to achieve the palliative effect: local surgical excision, penis amputation, radiotherapy or chemotherapy.
  • Nevertheless, the prognosis is poor, because the disease is already disseminated and in most cases other metastases will occur soon.
  • [MeSH-major] Penile Neoplasms / secondary. Penile Neoplasms / therapy. Urogenital Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma / diagnosis. Carcinoma / secondary. Carcinoma / therapy. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis

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  • (PMID = 12458336.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovakia
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16. Pizzocaro G, Nicolai N, Milani A: Taxanes in combination with cisplatin and fluorouracil for advanced penile cancer: preliminary results. Eur Urol; 2009 Mar;55(3):546-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Taxanes in combination with cisplatin and fluorouracil for advanced penile cancer: preliminary results.
  • BACKGROUND: Chemotherapy is emerging in the management of advanced penile cancer.
  • OBJECTIVE: To evaluate the therapeutic activity of taxanes (T) in combination with cisplatin-fluorouracil (PF) for salvage of primarily unresectable or relapsed nodal metastases from squamous cell carcinoma (SCC) of the penis.
  • DESIGN, SETTING, AND PARTICIPANTS: Six consecutive patients were treated at Istituto Nazionale Tumori (INT), Milano, with neoadjuvant paclitaxel, cisplatin, and 5-fluorouracil (TPF) for unresectable (two cases) or recurrent nodal metastases (four cases) from SCC of the penis from 2004 to 2006.
  • MEASUREMENTS: Patients underwent computed tomography (CT) scans before starting chemotherapy, after two courses, and at the end of chemotherapy.
  • RESULTS AND LIMITATIONS: Two patients received more than four courses: Both had pathologically documented complete remission, and they are alive and disease free >2 yr after chemotherapy.
  • The first patient had subjective intolerance to TPF: He underwent early postchemotherapy radical lymph node dissection, which documented >90% tumour necrosis: He is alive and disease free 46 mo after starting chemotherapy.
  • Of the other three patients, one was not responsive, changed therapy, and died within 4 mo.
  • Both refused to complete chemotherapy, and they relapsed after 10 and 4 mo.
  • CONCLUSIONS: TPF chemotherapy for unresectable or recurrent nodal metastases from SCC of the penis is promising, and the standard four courses of therapy are to be completed in responding patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Penile Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Taxoids / therapeutic use

  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • Hazardous Substances Data Bank. TAXOL .
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  • [CommentIn] Eur Urol. 2009 Mar;55(3):552-3; discussion 554-5 [19062154.001]
  • (PMID = 18649992.001).
  • [ISSN] 1873-7560
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Taxoids; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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17. Preis E, Jakse G: [The significance of inguinal lymphadenectomy in carcinoma of the penis]. Urologe A; 2006 Sep;45 Suppl 4:176-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The significance of inguinal lymphadenectomy in carcinoma of the penis].
  • The occurrence of inguinal lymph node metastases from squamous cell carcinoma of the penis depends on local tumor extension, tumor grade, and vascular invasion.
  • Whilst imaging techniques and fine needle biopsy can detect metastases to the inguinal nodes, resection of the superficial inguinal nodes remains the procedure of choice for diagnosis.
  • Resection of the sentinel lymph node marked by (99)Tc and dye has not yet been adequately evaluated as an alternative to be accepted as the standard method.When the superficial inguinal lymph nodes are found to harbor metastases the next step is a radical bilateral inguinal lymphadenectomy.
  • When metastases are found in two lymph nodes or extranodal tumor growth is observed, or imaging techniques reveal enlarged nodes in the pelvis the lymphadenectomy is extended to the pelvic nodes.
  • Chemotherapy and radiotherapy and the two combined have not been tested for efficacy, but are used individually before and after surgery, depending on the local tumor extent.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lymph Node Excision / methods. Penile Neoplasms / surgery
  • [MeSH-minor] Germany. Humans. Inguinal Canal. Lymphatic Metastasis / pathology. Male. Neoplasm Invasiveness. Neoplasm Staging. Penis / pathology. Postoperative Complications / etiology. Practice Guidelines as Topic. Prognosis. Sentinel Lymph Node Biopsy

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  • (PMID = 16933120.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 46
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18. Meineke V, Köhn FM, Pickl U, Ring J, Vogt HJ: [Malignant priapism as a sign of a recurrent prostate cancer. Differential diagnosis of induratio penis plastica]. Hautarzt; 2003 Jun;54(6):541-3
Hazardous Substances Data Bank. EPIRUBICIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant priapism as a sign of a recurrent prostate cancer. Differential diagnosis of induratio penis plastica].
  • [Transliterated title] Maligner Priapismus bei rezidivierendem Prostatakarzinom. Eine Differenzialdiagnose zur Induratio penis plastica.
  • A 62-year-old patient was referred with the suspected diagnosis of Peyronie disease.
  • The patient showed the clinical picture of a beginning malignant priapism with hematogenous metastases from an recurrent prostatic carcinoma.
  • The penile metastases were misdiagnosed as Peyronie disease.
  • [MeSH-major] Penile Induration / diagnosis. Penile Neoplasms / diagnosis. Penile Neoplasms / secondary. Priapism / etiology. Prostatic Neoplasms
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Agents, Hormonal / therapeutic use. Diagnosis, Differential. Drug Therapy, Combination. Epirubicin / administration & dosage. Epirubicin / therapeutic use. Estramustine / administration & dosage. Estramustine / therapeutic use. Flutamide / therapeutic use. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Orchiectomy. Palliative Care. Time Factors

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  • (PMID = 12759740.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Hormonal; 35LT29625A / Estramustine; 3Z8479ZZ5X / Epirubicin; 76W6J0943E / Flutamide
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19. Añibarro Laca E, Pérez-Irezabal Pindado JC, Ibáñez Calle T, Llarena Ibarguren R: [Metastases from a rectal adenocarcinoma to the prepuce]. Arch Esp Urol; 2006 Sep;59(7):737-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastases from a rectal adenocarcinoma to the prepuce].
  • [Transliterated title] Metastasis subcutáneas en prepucio secundarias a adenocarcinoma de recto.
  • OBJECTIVE: We report one case of metastatic dissemination of a rectal adenocarcinoma to the prepuce.
  • METHODS: 61-year-old patient with the diagnosis of rectal adenocarcinoma treated 18 months before by surgery and chemotherapy.
  • He presents with a painful enlargement of the penis associated with outgrowing erythematous lesions in the skin of the prepuce that bled on touch and did not allow the vision of the meatus and the glans penis.
  • Physical examination showed the presence of hypogostric, penile and scrotal lymphedema.
  • RESULTS: The pathologic study reported a moderately differentiated intestinal type adenocarcinoma with high mitotic index infiltrating the squamous cell flat epithelium of the prepuce.
  • CONCLUSIONS: Although extremely rare, tumor implants in the prepuce secondary to extra urologic tumors are exceptional.
  • Surgical excision confirms the origin and may avoid bleeding and discomfort, and also may help with catheterization, which is many times necessary in the final stages.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Rectal Neoplasms / pathology

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  • [CommentIn] Arch Esp Urol. 2006 Nov;59(9):926; author reply 927 [17190224.001]
  • (PMID = 17078400.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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20. Sánchez-Ortiz R, Huang SF, Tamboli P, Prieto VG, Hester G, Pettaway CA: Melanoma of the penis, scrotum and male urethra: a 40-year single institution experience. J Urol; 2005 Jun;173(6):1958-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanoma of the penis, scrotum and male urethra: a 40-year single institution experience.
  • PURPOSE: Genitourinary melanoma is rare and classically associated with a poor prognosis.
  • We describe our experience with 10 patients with penile or urethral involvement.
  • RESULTS: Of 10 patients with penile or urethral melanoma 1997 American Joint Committee on Cancer melanoma pathological stage was T1 (depth less than 0.75 mm) in 4, T2 (0.75 to 1.5 mm) in 3 and T3 (1.51 to 4 mm) in 3.
  • Only 1 of 4 patients with clinically palpable inguinal nodes had inguinal metastases at lymphadenectomy (BILND) and 3 who underwent prophylactic superficial BILND had negative findings.
  • One patient died of melanoma that developed at a second primary site.
  • In all patients with penile melanoma the 5-year actuarial disease specific and recurrence-free survival rates were 80% and 60%, respectively, at a median followup of 39 months (range 20 to 210).
  • Three of the 6 patients had palpable inguinal nodes, of whom 2 died after chemotherapy for unresectable disease and 1 died of other causes 51 months after negative BILND.
  • The 3 men with clinically negative groins who did not undergo prophylactic BILND had distant (1) or regional (2) metastases and died of disease.
  • CONCLUSIONS: Partial penectomy or WLE provided effective local control for low stage penile or urethral melanomas and all scrotal lesions.
  • Patients showing clinically positive, proven metastasis died despite appropriate surgical procedures and multi-agent chemotherapy.
  • Prophylactic modified inguinal lymphadenectomy should be considered in select patients with penile, scrotal and anterior urethral melanoma.
  • [MeSH-major] Genital Neoplasms, Male / surgery. Melanoma / surgery. Penile Neoplasms / surgery. Scrotum / surgery. Urethral Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Disease-Free Survival. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Retrospective Studies. Survival Rate

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  • [CommentIn] J Urol. 2006 Apr;175(4):1574-5; author reply 1575-6 [16516049.001]
  • (PMID = 15879790.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. García Rodríguez J, Fernández Gómez JM, Rodríguez Martínez JJ, Rodríguez Faba O, Jalón Monzón A, San Martín Blanco A, Martínez Gómez FJ, Sánchez Trilla A, Martín Benito JL, Escaf Barmadah S, Regadera Sejas J: [Clinical course of epidermoid carcinoma of the penis in our series]. Arch Esp Urol; 2003 Jan-Feb;56(1):30-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical course of epidermoid carcinoma of the penis in our series].
  • [Transliterated title] Análisis de la evolución del carcinoma epidermoide de pene en nuestra serie.
  • OBJECTIVES: To study the evolution of 49 patients with squamous cell carcinoma of the penis.
  • METHODS: 49 patients who underwent surgery for squamous cell carcinoma of the penis (30 partial penile amputations, 11 total amputations and 7 circumcisions).
  • 27 inguinal lymphadenectomies, superficial, profound and ilio-obturator (2 cases), were performed due to persistent lymph nodes after penile amputation despite of antibiotic treatment for 4 weeks, or to high grade primary tumour.
  • 13 patients were found to have lymph node metastases after treatment, receiving posterior adjuvant treatment with radiotherapy, chemotherapy or a combination of them.
  • Patients were followed in relation to stage, cell differentiation degree, and presence or absence of positive lymph nodes and distant metastases.
  • Lymph node metastasis were detected in 13 patients (26.53%) after lymph node dissection.
  • 6 patients died from tumour dissemination, 2 of them were T2G2, one T2G1, and three T1G2; two additional patients died from causes different from the tumour, all of them being N+ at the time of diagnosis.
  • CONCLUSIONS: Penile squamous cell carcinoma is an aggressive tumour the evolution of which mainly depends on the local-regional stage at the time of diagnosis and cell differentiation; these factors will condition lymphadenectomy versus observation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Penile Neoplasms / pathology. Penile Neoplasms / surgery

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  • (PMID = 12701478.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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22. Bouchot O, Rigaud J: [Diagnosis and treatment of penis cancer]. Presse Med; 2010 Sep;39(9):871-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and treatment of penis cancer].
  • [Transliterated title] Diagnostic et traitement du cancer du pénis.
  • Penile cancer is a rare tumor in Europe and is therefore associated with risks of diagnostic delay for stage Ta-T1 tumors or pre-epitheliomatous lesions and of an inadequate treatment strategy.
  • Clinical examination by palpation is essential in primary tumors to look for infiltration in the corpus spongiosum and the tunica albuginea of the corpus cavernosa of the penis, and in the lymphatic drainage areas, in particular in the upper inner quadrant of the inguinal lymph nodes.
  • The work-up must include: a biopsy in the case of diagnostic doubt, lymph node aspiration in the case of palpable adenopathies, and whole-body computed tomography (CT).
  • Treatment of the primary tumor can include partial amputation for tumors infiltrating the corpus cavernosa, or conservative treatment for tumors limited to the glands if the diameter is less than 30 mm, after an initial circumcision.
  • Groups at risk of lymph node metastases have been defined as a function of the pathology results of their primary tumors.
  • In these groups at risk, or in the case of clinical lymph node metastasis, dissection of the lymph node has an important role, permitting 5-year survival rates greater than 80 % when the number of metastatic lymph nodes is ≤ 1-2.
  • In the case of more extensive lymph node spread, a combination of chemotherapy and surgery must be discussed in multidisciplinary meetings, especially for younger patients.
  • [MeSH-major] Penile Neoplasms / diagnosis. Penile Neoplasms / therapy
  • [MeSH-minor] Algorithms. Humans. Male. Neoplasm Staging

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20494544.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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23. de los Rios Osorio J, Castro Alvarez EA: [Analysis of 5000 vasectomies at a family planning clinic in Medellin-Colombia]. Arch Esp Urol; 2003 Jan-Feb;56(1):53-60
MedlinePlus Health Information. consumer health - Vasectomy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To study the evolution of 49 patients with squamous cell carcinoma of the penis.
  • METHODS: 49 patients who underwent surgery for squamous cell carcinoma of the penis (30 partial penile amputations, 11 total amputations and 7 circumcisions).
  • 27 inguinal lymphadenectomies, superficial, profound and ilio-obturator (2 cases), were performed due to persistent lymph nodes after penile amputation despite of antibiotic treatment for 4 weeks, or to high grade primary tumour.
  • 13 patients were found to have lymph node metastases after treatment, receiving posterior adjuvant treatment with radiotherapy, chemotherapy or a combination of them.
  • Patients were followed in relation to stage, cell differentiation degree, and presence or absence of positive lymph nodes and distant metastases.
  • Lymph node metastasis were detected in 13 patients (26.53%) after lymph node dissection.
  • 6 patients died from tumour dissemination, 2 of them were T2G2, one T2G1, and three T1G2; two additional patients died from causes different from the tumour, all of them being N+ at the time of diagnosis.
  • CONCLUSIONS: Penile squamous cell carcinoma is an aggressive tumour the evolution of which mainly depends on the local-regional stage at the time of diagnosis and cell differentiation; these factors will condition lymphadenectomy versus observation.

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  • (PMID = 12701481.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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24. Ferreira AJ, Jaggy A, Varejão AP, Ferreira ML, Correia JM, Mulas JM, Almeida O, Oliveira P, Prada J: Brain and ocular metastases from a transmissible venereal tumour in a dog. J Small Anim Pract; 2000 Apr;41(4):165-8
MedlinePlus Health Information. consumer health - Eye Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brain and ocular metastases from a transmissible venereal tumour in a dog.
  • A five-year-old crossbred dog was referred with rapidly growing masses over its penis and right popliteal lymph node.
  • A presumptive diagnosis of transmissible venereal tumour (TVT) and iridocyclitis was made based on the results of fine needle aspiration.
  • Chemotherapy with vincristine and prednisolone was initiated and after four months the dog made a complete recovery.
  • In addition, the dog exhibited generalised 'grand mal' type seizures.
  • On histopathology, metastases of TVT in the left eye and left cerebral hemisphere were found, showing no specific staining for CD3, immunoglobulin (Ig) G, IgM and lambda light chains.
  • It was therefore concluded that the tumour growth was progressive, and that there was an absence of local humoral immune response against TVT in this case.
  • [MeSH-minor] Animals. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dogs. Male. Seizures / veterinary

  • MedlinePlus Health Information. consumer health - Brain Tumors.
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  • (PMID = 10812546.001).
  • [ISSN] 0022-4510
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] ENGLAND
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25. Cathomas R, Geldart TR, Iveson T, Singh N, Rowen D: An unusual differential diagnosis of penile warts: metastases from rectal carcinoma. Int J STD AIDS; 2006 Jul;17(7):491-2
MedlinePlus Health Information. consumer health - Warts.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual differential diagnosis of penile warts: metastases from rectal carcinoma.
  • Patients with penile lesions, such as virally induced papillomata, frequently present to genitourinary medicine clinics and general practitioners.
  • Their diagnosis is usually based on clinical observation and biopsy is not generally undertaken.
  • Penile lesions may rarely have a more sinister aetiology and represent metastatic spread from solid tumours arising at distant sites.
  • Penile metastases arise most frequently from genitourinary cancers (prostate, bladder and kidney), but may also arise from tumours of the large bowel; other primary sites are extremely uncommon.
  • We report the case of a patient presenting with penile metastases from rectal carcinoma arising during third-line chemotherapy for metastatic disease.
  • [MeSH-major] Adenocarcinoma / secondary. Penile Neoplasms / secondary. Penis / pathology. Rectal Neoplasms / pathology. Warts / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Penile Diseases / diagnosis. Penile Diseases / pathology

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  • (PMID = 16820084.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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26. Zheng FF, Liang YY, Guo YS, Dai YP, Zheng KL: [Diagnosis and therapy for penile cancer: a report of 46 cases with literature review]. Ai Zheng; 2008 Sep;27(9):962-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and therapy for penile cancer: a report of 46 cases with literature review].
  • BACKGROUND & OBJECTIVE: Penile cancer is an uncommon malignancy, which is mainly treated by surgery, radiation and chemotherapy.
  • This study was to investigate reasonable curative methods for penile cancer.
  • METHODS: Medical records of 46 patients with penile cancer in the Department of Urology, The First Affiliated Hospital of Sun Yat-sen University between Jan.
  • Prognosis of patients with pelvic lymph node metastasis was poor.
  • Two patients who had pelvic lymph node metastasis died of lung metastasis within two years after surgery.
  • CONCLUSIONS: Partial penectomy is an appropriate and effective management for penile cancer.
  • Lymph node metastasis is an important prognostic factor for penile cancer.
  • Patients with ilioinguinal lymph node metastasis should receive lymphadenectomy as early as possible to improve the therapeutic effect.
  • The prognosis is poor for patients with pelvic lymph node metastases.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Penile Neoplasms / surgery. Penis / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Verrucous / pathology. Carcinoma, Verrucous / surgery. Carcinoma, Verrucous / therapy. Chemotherapy, Adjuvant. Follow-Up Studies. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Paget's Disease, Mammary / pathology. Paget's Disease, Mammary / surgery. Paget's Disease, Mammary / therapy. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 18799036.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 12
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27. Mosconi AM, Roila F, Gatta G, Theodore C: Cancer of the penis. Crit Rev Oncol Hematol; 2005 Feb;53(2):165-77

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer of the penis.
  • Cancer of the penis is rare in Europe, accounting for less than 0.5% of all cancers.
  • More than 95% of penile carcinomas are squamous cell carcinomas.
  • Early disease (stage I-II) is curable in most patients, who can be treated by conventional penile amputation or, in selected cases, by organ preserving techniques, including Moh's micrographic surgery, laser ablation or radiation therapy (external-beam, brachytherapy).
  • For more advanced primary tumours, penile amputation is required.
  • Survival of patients with penile cancer is strongly related to the presence and extent of nodal metastases.
  • Bilateral inguinal lymphadenectomy is recommended for palpable lymph nodes that persist 3 or more weeks after removal of the primary tumour and a course of antibiotic therapy.
  • In patients with proven inguinal lymph node metastases, bilateral ileoinguinal dissection should be performed.
  • The role of chemotherapy, as adjuvant and neoadjuvant or primary treatment in metastatic disease, needs to be further explored in prospective clinical trials.
  • [MeSH-major] Carcinoma, Squamous Cell. Penile Neoplasms

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  • (PMID = 15661566.001).
  • [ISSN] 1040-8428
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 98
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28. Chakŭrov S: [Current progress and problems in oncourology]. Khirurgiia (Sofiia); 2007;(3):54-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A large part of the scientific research is dedicated to their basic research, diagnostics and treatment as the results are then presented at the big international forums each year.
  • The overview is a panorama of the newest and at the same time most significant achievements of the science of urology in this field in 2006 presented at the biggest international congresses - the Congress of the European Association of Urology, the Annual Meeting of the American urologists and the Congress of the American Society of Clinical Oncology - ASCO.
  • What is especially impressive in bladder cancer research is the discovery of a protein element called "survivin", which is of the family of the inhibitors of apoptosis and its level is connected with qualities of the tumors like aggressiveness, recurrence and progression of the disease and mortality rate.
  • After quite a few years of standstill in the area of chemotherapy new drugs like Sunitinib, Sorafenib and Temserolimus are being introduced, some of which even have independent antitumor effect.
  • The increased possibilities of conservative treatment of the lymph node metastases are stressed though radiation therapy and chemotherapy, especially in the cases of seminoma tumors.
  • In the case of penis cancer the weight is placed on the timely diagnostics and treatment allowing organ-preserving operations.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • (PMID = 18437112.001).
  • [ISSN] 0450-2167
  • [Journal-full-title] Khirurgii︠a︡
  • [ISO-abbreviation] Khirurgiia (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Bulgaria
  • [Chemical-registry-number] 0 / Biomarkers
  • [Number-of-references] 38
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29. Mentzel T, Kuhnen C: Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch; 2006 Nov;449(5):554-60
MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Four neoplasms arose on the lower extremities and one case each on the forearm, the lateral aspect of the neck and the penis.
  • Five neoplasms were completely excised, in one incompletely excised neoplasm additional chemotherapy was given, and in one patient a biopsy was done only so far.
  • All neoplasms arose in subcutaneous and deep soft tissues with dermal involvement in one case, and the size of the neoplasms ranged from 4 to 19 cm in largest diameter.
  • Histologically, a plump or diffuse infiltration was seen, and all neoplasms were mainly composed of cellular bands and fascicles of atypical spindle-shaped tumour cells containing enlarged and atypical nuclei associated with a variable number of rhabdomyoblasts.
  • In addition, focal areas reminiscent of sclerosing, pseudovascular RMS were noted in three cases, and in two cases each small solid areas with pleomorphic tumour cells as well as scattered round tumour cells were present.
  • Proliferative activity ranged from 1 to 60 mitoses in 10 high-power fields and tumour necrosis was evident in four cases.
  • Follow-up information was available in five patients (range from 10 to 48 months) and revealed lung metastases in two patients who died of disease within a short period.
  • In summary, spindle cell rhabdomyosarcoma represents a rare neoplasm in adulthood characterized clinically by a rather poor prognosis, and shows a broad morphological spectrum including most likely the sclerosing, pseudovascular variant.
  • Immunohistochemically, tumour cells in RMS stain positively for CD 99 and WT1 as well, which is of importance in the differential diagnosis to other mesenchymal neoplasms, whereas fast myosin does not represent a reliable marker for RMS in adults.
  • [MeSH-major] Rhabdomyosarcoma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17013628.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD99; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules
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