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1. Takahashi T, Tsukuda H, Kimura H, Yoshimoto M, Tsujisaki M: Extramedullary relapse of AML with t(9;11)(p22;q23) associated with clonal evolution from trisomy 8 into tetrasomy 8. Intern Med; 2010;49(5):447-51
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  • [Title] Extramedullary relapse of AML with t(9;11)(p22;q23) associated with clonal evolution from trisomy 8 into tetrasomy 8.
  • A 57-year-old man was diagnosed as having acute monoblastic leukemia with t(9;11)(p22;q23) and trisomy 8.
  • Ten months after achieving complete response (CR) with chemotherapy, masses developed in his left forearm and in the back of his thigh, preceded by enigmatic peripheral neurological symptoms.
  • Bone marrow or meningeal relapse was not observed.
  • To our knowledge, this is the first case report of clonal evolution associated with the development of myeloid sarcoma as a relapse in AML.
  • [MeSH-major] Chromosomes, Human, Pair 11 / genetics. Chromosomes, Human, Pair 8 / genetics. Chromosomes, Human, Pair 9 / genetics. Leukemia, Myeloid, Acute / genetics. Sarcoma, Myeloid / diagnosis. Sarcoma, Myeloid / genetics. Trisomy / genetics
  • [MeSH-minor] Chromosome Aberrations. Drug Therapy. Forearm. Humans. Male. Middle Aged. Recurrence. Thigh

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  • (PMID = 20190481.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Furuno Y, Nishimura S, Kamiyama H, Numagami Y, Saito A, Kaimori M, Nishijima M: Intracranial peripheral-type primitive neuroectodermal tumor. Neurol Med Chir (Tokyo); 2008 Feb;48(2):72-6
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  • [Title] Intracranial peripheral-type primitive neuroectodermal tumor.
  • Digital subtraction angiography of the external carotid artery revealed sunburst appearance corresponding to the tumor, which was fed by the right middle meningeal artery.
  • His headache worsened and computed tomography revealed enlargement of the tumor and intracystic hemorrhage, so emergent operation was performed.
  • The histological diagnosis was peripheral-type primitive neuroectodermal tumor (pPNET).
  • Following surgery, radiation therapy and chemotherapy were given.
  • Ewing's sarcoma and pPNET form a family of small round cell tumors arising in the bone or soft tissue.
  • MIC-2 is a useful marker in the differential diagnosis.
  • [MeSH-minor] Adolescent. Antigens, CD / metabolism. Biomarkers, Tumor / metabolism. Cell Adhesion Molecules / metabolism. Diagnosis, Differential. Frontal Lobe / pathology. Headache / etiology. Headache / pathology. Humans. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging. Male. Temporal Lobe / pathology. Tomography, X-Ray Computed

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  • (PMID = 18296876.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Ki-67 Antigen
  • [Number-of-references] 20
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3. Sáez D, Bahamondes L, Lam G, Arellano L, Lillo P: [Inflammatory reconstitution immune syndrome associated to antiretroviral therapy and meningeal cryptococcosis]. Rev Med Chil; 2006 Oct;134(10):1310-4
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  • [Title] [Inflammatory reconstitution immune syndrome associated to antiretroviral therapy and meningeal cryptococcosis].
  • [Transliterated title] Síndrome de restauración inmune asociado a tratamiento antirretroviral y criptococosis meníngea. Caso clínico.
  • The objective of high activity antiretroviral therapy (HAART) in patients with AIDS, is to obtain immune restoration.
  • Nevertheless, this treatment sometimes results in the reappearance of previous symptoms from treated conditions due to opportunistic infections (ie: tuberculosis, criptococcosis, hepatitis, Pneumocystis jirovesi, toxoplasmosis, etc) or non infectious condition such as sarcoidosis, Graves disease or Kaposi sarcoma.
  • She was treated, achieving a marked improvement with treatment and subsequent suppressive therapy with fluconazole 200 mg/day.
  • IRIS appeared after 8 months of ongoing antiretroviral therapy with immune restoration with the development of aseptic meningitis and intracranial hypertension.
  • The patient condition improved with general measures, such as a repeated lumbar punctures and non steroidal anti-inflammatory drugs.
  • [MeSH-major] AIDS-Related Opportunistic Infections / chemically induced. Acquired Immunodeficiency Syndrome / drug therapy. Antiretroviral Therapy, Highly Active / adverse effects. Immune Reconstitution Inflammatory Syndrome / complications. Meningitis, Cryptococcal / chemically induced


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4. Raney RB, Meza J, Anderson JR, Fryer CJ, Donaldson SS, Breneman JC, Fitzgerald TJ, Gehan EA, Michalski JM, Ortega JA, Qualman SJ, Sandler E, Wharam MD, Wiener ES, Maurer HM, Crist WM: Treatment of children and adolescents with localized parameningeal sarcoma: experience of the Intergroup Rhabdomyosarcoma Study Group protocols IRS-II through -IV, 1978-1997. Med Pediatr Oncol; 2002 Jan;38(1):22-32
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  • [Title] Treatment of children and adolescents with localized parameningeal sarcoma: experience of the Intergroup Rhabdomyosarcoma Study Group protocols IRS-II through -IV, 1978-1997.
  • BACKGROUND: We reviewed 611 patients with parameningeal sarcoma entered on Intergroup Rhabdomyosarcoma Study Group (IRSG) Protocols-II through IV (1978-1997), to delineate treatment results and evaluate prognostic factors.
  • PROCEDURE: Primary sites were the middle ear/mastoid (N = 138), nasopharynx/nasal cavity (N = 235), paranasal sinuses (N = 132), parapharyngeal region (N = 29), and the pterygopalatine/infratemporal fossa (N = 77).
  • Treatment was initial biopsy or surgery followed by multiagent chemotherapy and radiation therapy (XRT).
  • Beginning in 1977, patients with cranial nerve palsy, cranial base bony erosion, and/or intracranial extension at diagnosis were considered as having meningeal involvement.
  • They received triple intrathecal medications, whole brain XRT, and then spinal XRT.
  • These treatments were successively eliminated from 1980 to 1991.
  • Favorable prognostic factors were: age 1-9 years at diagnosis; primary tumor in the nasopharynx/nasal cavity, middle ear/mastoid, or parapharyngeal areas; no meningeal involvement; and non-invasive tumors (T1).
  • Thirty-five of 526 patients (6.7%) with information about presence/absence of meningeal involvement at diagnosis developed central nervous system (CNS) extension at 5-164 weeks (median, 46 weeks) after starting therapy.
  • CONCLUSIONS: Biopsy, XRT to the target volume, and systemic chemotherapy are successful treatments for the large majority of patients with localized parameningeal sarcoma.
  • [MeSH-major] Head and Neck Neoplasms / therapy. Meningeal Neoplasms / therapy. Outcome Assessment (Health Care). Rhabdomyosarcoma / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Clinical Protocols. Combined Modality Therapy. Cytarabine / administration & dosage. Female. Humans. Hydrocortisone / administration & dosage. Infant. Infant, Newborn. Injections, Spinal. Male. Methotrexate / administration & dosage. Neoplasm Invasiveness. Prognosis. Radiation Dosage. Randomized Controlled Trials as Topic. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright 2002 Wiley‐Liss, Inc.
  • (PMID = 11835233.001).
  • [ISSN] 0098-1532
  • [Journal-full-title] Medical and pediatric oncology
  • [ISO-abbreviation] Med. Pediatr. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-24507; United States / NCI NIH HHS / CA / CA-29511; United States / NCI NIH HHS / CA / CA-72989
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; WI4X0X7BPJ / Hydrocortisone; YL5FZ2Y5U1 / Methotrexate
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5. Balleari E, Panarello S, Capello E, Grosso M, Passalia C, Pitto P, Raggi F, Roccatagliata L, Cabiddu F, Ghio R: Granulocytic sarcoma: an unusual cause of spinal cord compression. Int J Clin Oncol; 2007 Jun;12(3):234-7
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  • [Title] Granulocytic sarcoma: an unusual cause of spinal cord compression.
  • At subsequent clinical workup, a diagnosis of granulocytic sarcoma with meningeal involvement was made.
  • Unfortunately, despite receiving intensive care, shortly after induction chemotherapy, the patient died of acute pneumonia followed by acute respiratory distress syndrome.
  • [MeSH-major] Sarcoma, Myeloid / pathology. Spinal Cord Compression / etiology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Magnetic Resonance Imaging

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  • (PMID = 17566850.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 10
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6. Bisogno G, De Rossi C, Gamboa Y, Sotti G, Ferrari A, Dallorso S, Donfrancesco A, Cecchetto G, Calderone M, Gandola L, Rosolen A, Carli M: Improved survival for children with parameningeal rhabdomyosarcoma: results from the AIEOP soft tissue sarcoma committee. Pediatr Blood Cancer; 2008 Jun;50(6):1154-8
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  • [Title] Improved survival for children with parameningeal rhabdomyosarcoma: results from the AIEOP soft tissue sarcoma committee.
  • BACKGROUND: Parameningeal rhabdomyosarcoma (PM-RMS) is a rare, highly malignant pediatric tumor arising from locations adjacent to the meninges, from where it can spread intracranially.
  • PROCEDURE: We reviewed 109 children with non-metastatic PM-RMS enrolled in the Italian RMS79, RMS88 and RMS96 protocols over a 24-year period.
  • All patients received intensive chemotherapy and standard or hyperfractionated and accelerated radiotherapy.
  • RESULTS: Five-year overall survival rose from 40% in the RMS79 to 72% in the RMS88 and RMS96 protocols (P = 0.01), where more intensive chemotherapy and hyperfractionated accelerated radiotherapy (HART) was used.
  • Delayed surgery after initial treatment was statistically associated with a better prognosis.
  • CONCLUSION: Outcome in PM-RMS patients enrolled in three consecutive Italian protocols has progressively improved, as a result of intensive chemotherapy, delayed surgery and, possibly, HART, though improved imaging and radiotherapeutic tools may have had a role as well.
  • [MeSH-major] Meningeal Neoplasms / mortality. Rhabdomyosarcoma / mortality
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Female. Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / therapy. Humans. Infant. Male. Prognosis. Survival Rate

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18300319.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Stepensky P, Revel-Vilk S, Yehuda-Gafni O, Mali B, Resnick IB, Weintraub M: Isolated central nervous system granulocytic sarcoma and meningeal myeloid leukemia: successful treatment without radiotherapy. Isr Med Assoc J; 2009 Sep;11(9):569-70
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  • [Title] Isolated central nervous system granulocytic sarcoma and meningeal myeloid leukemia: successful treatment without radiotherapy.
  • [MeSH-major] Leukemia, Myeloid / drug therapy. Leukemia, Myeloid / pathology. Leukemic Infiltration. Meninges / pathology
  • [MeSH-minor] Acute Disease. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child, Preschool. Cytogenetic Analysis. Female. Humans. Immunohistochemistry. Injections, Spinal. Remission Induction. Time Factors

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  • (PMID = 19960855.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Israel
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8. Timmermann B, Schuck A, Niggli F, Weiss M, Lomax AJ, Pedroni E, Coray A, Jermann M, Rutz HP, Goitein G: Spot-scanning proton therapy for malignant soft tissue tumors in childhood: First experiences at the Paul Scherrer Institute. Int J Radiat Oncol Biol Phys; 2007 Feb 1;67(2):497-504
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  • [Title] Spot-scanning proton therapy for malignant soft tissue tumors in childhood: First experiences at the Paul Scherrer Institute.
  • PURPOSE: Radiotherapy plays a major role in the treatment strategy of childhood sarcomas.
  • Consequences of treatment are likely to affect the survivor's quality of life significantly.
  • We investigated the feasibility of spot-scanning proton therapy (PT) for soft tissue tumors in childhood.
  • METHODS AND MATERIALS: Sixteen children with soft tissue sarcomas were included.
  • Fourteen children had chemotherapy before and during PT.
  • All 16 children were treated with spot-scanning proton therapy at the Paul Scherrer Institute, and in 3 children the PT was intensity-modulated (IMPT).
  • Acute toxicity was low, with Grade 3 or 4 side effects according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC) criteria occurring in the bone marrow only.
  • CONCLUSIONS: Proton therapy was feasible and well tolerated.
  • [MeSH-major] Protons / therapeutic use. Sarcoma / radiotherapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Feasibility Studies. Female. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / radiotherapy. Humans. Infant. Male. Meningeal Neoplasms / drug therapy. Meningeal Neoplasms / mortality. Meningeal Neoplasms / radiotherapy. Quality of Life. Radiation Injuries / pathology. Rhabdomyosarcoma, Embryonal / drug therapy. Rhabdomyosarcoma, Embryonal / mortality. Rhabdomyosarcoma, Embryonal / radiotherapy. Spinal Neoplasms / drug therapy. Spinal Neoplasms / mortality. Spinal Neoplasms / radiotherapy. Survivors

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  • (PMID = 17084557.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons
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9. Alvarez M: Intracerebral granulocytic sarcoma. J Neurosci Nurs; 2007 Oct;39(5):297-304
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  • [Title] Intracerebral granulocytic sarcoma.
  • Leukemia involvement of the central nervous system most commonly presents as meningeal leukemia; intracerebral granulocytic sarcoma (IGS) is rare.
  • Magnetic resonance imaging with and without gadolinium is the imaging of choice to evaluate the tumor; however, tissue biopsy is essential for definitive diagnosis.
  • Treatment usually involves radiation followed by chemotherapy, depending on the previous systemic treatment.
  • Because medical literature about IGS is scarce, optimal treatment is unclear.
  • Nurses play a vital role in helping patients and families understand the disease process, the treatments involved, and the necessary adjustments, such as performing mundane activities of daily living, especially when neurocognitive impairments are present.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications. Sarcoma, Myeloid / diagnosis. Sarcoma, Myeloid / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biopsy. Blood-Brain Barrier. Cerebral Hemorrhage / etiology. Cognition Disorders / etiology. Headache / etiology. Humans. Incidence. Infection / etiology. Leukemic Infiltration. Magnetic Resonance Imaging. Male. Middle Aged. Nurse's Role / psychology. Patient Education as Topic. Prognosis. Radiotherapy, Adjuvant. Rare Diseases. Tomography, X-Ray Computed. Tumor Lysis Syndrome / etiology

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  • (PMID = 17966297.001).
  • [ISSN] 0888-0395
  • [Journal-full-title] The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • [ISO-abbreviation] J Neurosci Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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10. El Khorassani M, Benbrahim F, Hessissen L, Khattab M, Msefer F: [Intracerebral granulocytic sarcoma. A case report]. Neurochirurgie; 2003 May;49(2-3 Pt 1):119-23
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  • [Title] [Intracerebral granulocytic sarcoma. A case report].
  • Granulocytic sarcoma is a tumor composed of proliferating myeloblastic cells, generally found in the orbit.
  • After 21 months of complete remission, he developed headache and facial palsy.
  • A new medullar and cerebro-meningeal remission was obtained with chemotherapy and radiotherapy.
  • CSF and the bone marrow studies can help avoid stereotaxic biopsy can be avoided in this type of tumor
  • [MeSH-major] Brain Stem Neoplasms / radiography. Leukemia, Myeloid, Acute / complications. Sarcoma, Myeloid / radiography
  • [MeSH-minor] Bone Marrow / pathology. Child. Combined Modality Therapy. Contrast Media. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 12746729.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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11. Sekiguchi N, Watanabe T, Kobayashi Y, Inokuchi C, Kim SW, Yokota Y, Tanimoto K, Matsuno Y, Tobinai K: The application of molecular analyses for primary granulocytic sarcoma with a specific chromosomal translocation. Int J Hematol; 2005 Oct;82(3):210-4
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  • [Title] The application of molecular analyses for primary granulocytic sarcoma with a specific chromosomal translocation.
  • Primary granulocytic sarcoma (GS) is a rare disease defined by the absence of antecedent or concomitant leukemic cells in the bone marrow and the peripheral blood.
  • Immunohistochemical staining for myeloperoxidase is necessary for a definite diagnosis.
  • Otherwise, primary GS is often misdiagnosed as a malignant lymphoma or other malignancies.
  • Here we describe a 28-year-old woman with primary GS manifesting as an epidural tumor in the sacral region accompanied by meningeal dissemination.
  • Systemic chemotherapy with high-dose cytarabine followed by local radiotherapy was performed, and the patient clinically achieved a complete response.
  • These molecular analyses provide a precise method of diagnosis, especially with respect to the French-American-British AML classification, according to the characteristic karyotypic alterations, and a patient consequently can quickly be given appropriate systemic chemotherapy as induction therapy.
  • [MeSH-major] Chromosomes, Human, Pair 21 / genetics. Chromosomes, Human, Pair 8 / genetics. Core Binding Factor Alpha 2 Subunit / genetics. Oncogene Proteins, Fusion / genetics. Sarcoma, Myeloid / genetics. Spinal Neoplasms / genetics. Translocation, Genetic
  • [MeSH-minor] Adult. Antimetabolites, Antineoplastic / administration & dosage. Combined Modality Therapy. Cytarabine / administration & dosage. DNA Mutational Analysis. Female. Hemibody Irradiation. Humans

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  • (PMID = 16207593.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / AML1-ETO fusion protein, human; 0 / Antimetabolites, Antineoplastic; 0 / Core Binding Factor Alpha 2 Subunit; 0 / Oncogene Proteins, Fusion; 04079A1RDZ / Cytarabine
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12. Navarro R, Laguna A, de Torres C, Cigudosa JC, Suñol M, Cruz O, Mora J: Primary Ewing sarcoma of the tentorium presenting with intracranial hemorrhage in a child. J Neurosurg; 2007 Nov;107(5 Suppl):411-5
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  • [Title] Primary Ewing sarcoma of the tentorium presenting with intracranial hemorrhage in a child.
  • The occurrence of primitive central nervous system lesions in the Ewing sarcoma family of tumors (ESFT) not related to bone or metastatic disease is a rare condition.
  • The authors report on a child who presented with intracranial bleeding secondary to a nonmetastatic tentorial ESFT confirmed by detection of the fusion gene EWS-ERG.
  • A detailed review of the literature reveals that most primary intracranial ESFT had a meningeal attachment, and that almost half of them presented at diagnosis with hemorrhage.
  • Distinguishing between ESFT and other intracranial neoplasms is essential because the treatment and prognosis differ remarkably from that of other tumors, namely central primitive neuroectodermal tumors (PNETs).
  • Whereas adjuvant treatment for ESFT consists of local or regional radiotherapy and chemotherapy containing alkylating agents, central PNETs are generally treated with whole neuraxis radiation and platinum-based chemotherapy.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / surgery. Intracranial Hemorrhages / etiology. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / surgery

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  • (PMID = 18459906.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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13. Ahn JY, Choi EW, Kang SH, Kim YR: Isolated meningeal chloroma (granulocytic sarcoma) in a child with acute lymphoblastic leukemia mimicking a falx meningioma. Childs Nerv Syst; 2002 Apr;18(3-4):153-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated meningeal chloroma (granulocytic sarcoma) in a child with acute lymphoblastic leukemia mimicking a falx meningioma.
  • Granulocytic sarcoma occurs primarily in patients with acute myelogenous leukemia, but can also arise in patients with other myeloproliferative disorders, though rarely in patients with acute lymphoblastic leukemia (ALL).
  • When dural-based, granulocytic sarcoma may be indistinguishable from meningioma radiologically.
  • CASE HISTORY: We now describe one patient affected by ALL with isolated granulocytic sarcoma mimicking meningioma as initial CNS relapses.
  • A 12-year-old girl who had been diagnosed with ALL and undergone chemotherapy presented with generalized tonic-clonic seizure while in complete remission.
  • The patient was developed speech disturbance 6 days later.
  • The pathological diagnosis was acute lymphoblastic leukemia.
  • Early detection and antileukemic treatment of granulocytic sarcoma are necessary and important for a favorable prognosis.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Neoplasms, Second Primary / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Sarcoma, Myeloid / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 11981624.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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14. Binder C, Tiemann M, Haase D, Humpe A, Kneba M: Isolated meningeal chloroma (granulocytic sarcoma)--a case report and review of the literature. Ann Hematol; 2000 Aug;79(8):459-62

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated meningeal chloroma (granulocytic sarcoma)--a case report and review of the literature.
  • There are still no conclusive treatment strategies for this entity; however, early antileukemic chemotherapy seems to lower the probability of developing systemic disease and prolong survival.
  • We report on a patient with isolated meningeal chloroma, primarily misdiagnosed as a high-grade Non-Hodgkin's lymphoma.
  • Two cycles of antileukemic induction chemotherapy were administered, followed by local irradiation and intensified consolidation therapy with autologous stem cell transplantation.
  • [MeSH-major] Leukemia, Myeloid / therapy. Meningeal Neoplasms / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Drug Therapy. Hematopoietic Stem Cell Transplantation. Humans. Male

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  • (PMID = 10985368.001).
  • [ISSN] 0939-5555
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] GERMANY
  • [Number-of-references] 40
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15. Sasayama T, Nishihara M, Tanaka K, Mizukawa K, Ehara K, Kanomata N, Kohmura E: Two metachronous tumors induced by radiation therapy: case report and review of the literature. J Neurooncol; 2008 Jul;88(3):315-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two metachronous tumors induced by radiation therapy: case report and review of the literature.
  • Various radiation-induced tumors, including meningioma, glioma, and sarcoma, have been reported; however, metachronous intracranial double tumors induced by radiation therapy are extremely rare.
  • A 1-year-old boy had undergone tumor removal and craniospinal radiation therapy (30 Gy) for cerebellar medulloblastoma.
  • At 24 years old, parasagittal meningioma developed in the left parietal region and was totally removed.
  • As the patient had previously had craniospinal irradiation, no additional radiation therapy was delivered.
  • He underwent chemotherapy with temozolomide and the disease is now stable.
  • Since both secondary tumors were located within the area of previous radiation and the patient did not have any genetic disease predisposing him to tumors, radiation therapy was considered to be responsible for their tumorigenesis.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 18373066.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Utsunomiya A, Uenohara H, Suzuki S, Shimosaka S, Numagami Y, Nishimura S, Nishino A, Suzuki H, Sakurai Y: [A case of peripheral-type primitive neuroectodermal tumor arising in the dura mater at the frontal base]. No To Shinkei; 2004 Mar;56(3):237-41
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of peripheral-type primitive neuroectodermal tumor arising in the dura mater at the frontal base].
  • Angiography showed the tumor was fed by anterior meningeal arteries.
  • The tumor was histologically confirmed to be peripheral-type primitive neuroectodermal tumor(pPNET).
  • Following surgery, he underwent whole brain, whole spine and local radiation therapy(30 Gy in total respectively) and received two 5-day cycles of chemotherapy, consisting of intravenous administration of cisplatin 20 mg/m2/day, etoposide 60 mg/m2/day and IFOS 900 mg/m2/day.
  • After these therapies, follow-up radiological examination showed there was no recurrence of the tumor for 24 months.
  • Ewing sarcoma and pPNET(ES/pPNET) is the designation given to a family of small round cell tumor arising in bone or soft tissues.
  • It is necessary that intracranial PNETs are divided into two types of PNETs because of different prognosis between these tumors.
  • MIC-2 is a specific marker for pPNET/ES family and is useful in the differential diagnosis of these two types of tumors.
  • [MeSH-major] Dura Mater. Meningeal Neoplasms / diagnosis. Neuroectodermal Tumors, Primitive, Peripheral / diagnosis
  • [MeSH-minor] Antigens, CD / analysis. Biomarkers, Tumor / analysis. Cell Adhesion Molecules / analysis. Chemotherapy, Adjuvant. Child. Diagnosis, Differential. Humans. Magnetic Resonance Angiography. Male. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 15112448.001).
  • [ISSN] 0006-8969
  • [Journal-full-title] Nō to shinkei = Brain and nerve
  • [ISO-abbreviation] No To Shinkei
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules
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17. Tamiya T, Ono Y, Daido S, Tokunaga K, Hamazaki S, Kawai A, Ohmoto T: Primary Ewing's sarcoma/peripheral primitive neuroectodermal tumor at the vertex of the skull with elevated serum carcinoembryonic antigen: case report. J Neurooncol; 2001 Apr;52(2):173-80
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  • [Title] Primary Ewing's sarcoma/peripheral primitive neuroectodermal tumor at the vertex of the skull with elevated serum carcinoembryonic antigen: case report.
  • A primary Ewing's sarcoma arising in the skull is relatively rare.
  • Although a small number of case reports noted elevated carcinoembryonic antigen (CEA) in patients with primary central nervous system (CNS) neoplasms, there is no report of Ewing's sarcoma/peripheral primitive neuroectodermal tumor (PNET) with elevated serum levels of CEA.
  • The patient initially underwent an embolization of the bilateral middle meningeal arteries with Gelfoam particles.
  • On histopathological and molecular genetic examination, the tumor was diagnosed as a Ewing's sarcoma/peripheral PNET.
  • The serum level of CEA was normalized at 0.83 ng/ml after the tumor was removed and the boy underwent radiotherapy and 3 courses of chemotherapy.
  • This is the first reported case of a primary Ewing's sarcoma/peripheral PNET at the vertex of the skull with elevated serum CEA.
  • [MeSH-major] Carcinoembryonic Antigen / blood. Neuroectodermal Tumors, Primitive / pathology. Sarcoma, Ewing / pathology. Skull Neoplasms / pathology

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  • (PMID = 11508817.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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18. Lopez-Gonzalez MA, Sotelo J: Brain tumors in Mexico: characteristics and prognosis of glioblastoma. Surg Neurol; 2000 Feb;53(2):157-62
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mean survival for glioblastoma was 16 months and the longest mean survival was obtained in patients with radical neurosurgical resection plus radiotherapy and chemotherapy.
  • Factors that showed prognostic significance were age, therapeutic approach, tumor size, and pre- and postoperative clinical status (p < 0.05).
  • Mean survival for glioblastoma was similar to other reports; in these patients, the overall therapeutic response is still far from satisfactory.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Glioma / diagnosis. Glioma / therapy
  • [MeSH-minor] Adenoma / diagnosis. Female. Glioblastoma / diagnosis. Humans. Karnofsky Performance Status. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Mexico / epidemiology. Middle Aged. Pituitary Neoplasms / diagnosis. Predictive Value of Tests. Prognosis. Retrospective Studies. Risk Factors. Sarcoma / diagnosis. Survival Analysis. Treatment Outcome

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  • (PMID = 10713194.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
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19. Case CC, Vassilopoulou-Sellin R: Reproduction of features of the glucagonoma syndrome with continuous intravenous glucagon infusion as therapy for tumor-induced hypoglycemia. Endocr Pract; 2003 Jan-Feb;9(1):22-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reproduction of features of the glucagonoma syndrome with continuous intravenous glucagon infusion as therapy for tumor-induced hypoglycemia.
  • OBJECTIVE: To describe the adverse effects of continuous intravenous infusion of glucagon as therapy for tumor-induced hypoglycemia and to correlate these treatment-related effects with symptoms of endogenous hyper-glucagonemia.
  • METHODS: We reviewed three cases in which patients received continuous glucagon therapy for tumor-induced hypoglycemia and experienced adverse side effects to the treatment.
  • RESULTS: Continuous intravenous glucagon infusion has evolved as a reliable and efficacious modality for the treatment of tumor-induced hypoglycemia.
  • We report the adverse events of venous thromboembolism, necrolytic migratory erythema, and angular cheilitis in conjunction with continuous intravenous glucagon treatment.
  • [MeSH-major] Glucagon / therapeutic use. Glucagonoma / metabolism. Hypoglycemia / drug therapy. Hypoglycemia / etiology. Insulinoma / metabolism. Pancreatic Neoplasms / metabolism
  • [MeSH-minor] Drug Eruptions / pathology. Female. Hemangioma / complications. Humans. Infusions, Intravenous. Lung Neoplasms / complications. Male. Meningeal Neoplasms / complications. Middle Aged. Pleural Neoplasms / complications. Sarcoma / complications


20. Jellinger KA, Setinek U, Drlicek M, Böhm G, Steurer A, Lintner F: Neuropathology and general autopsy findings in AIDS during the last 15 years. Acta Neuropathol; 2000 Aug;100(2):213-20
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  • A retrospective study of 450 consecutive AIDS autopsy cases (397 males, 53 females; mean age at death 38.4 years) in Vienna, Austria, between 1984 and 1999 compares the central nervous system (CNS) findings in three cohorts: 1984-1992 (190 cases), 1993-1995 (162 cases) and 1996-1999 (98 cases, after introduction of triple antiretroviral therapy) and the relationship of CNS findings to systemic AIDS pathology in the latter two cohorts.
  • Extracerebral protozoal (Pneumocystis carinii, toxoplasmosis), Mycobacterium avium complex, viral [e.g., cytomegalovirus (CMV)], multiple opportunistic organ and CNS infections, and Kaposi sarcoma significantly decreased over time.
  • Nonspecific CNS changes (e.g., meningeal fibrosis) increased.
  • In a cohort of drug abusers, HIV encephalitis, progressive multifocal leukoencephalopathy, bacterial infections, hepatic encephalopathy, and negative CNS findings were more frequent than in non-users who showed increased incidence of CMV, toxoplasmosis, or other opportunistic CNS infections, and nonspecific CNS findings; the frequency of lymphomas was similar in both drug abusers and non-users.
  • Similar to a recent autopsy study from San Diego, these data suggest that despite the beneficial effects of modern antiretroviral combination therapy, involvement of the brain in AIDS subjects continues to be a frequent autopsy finding, while the increased incidence of HIV encephalitis in our small cohort of drug users was less than observed in other recent autopsy studies.

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  • (PMID = 10963370.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY
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21. Drabko K, Choma M, Zaucha-Prazmo A, Wójcik B, Gorczyńska E, Kałwak K, Turkiewicz D, Słociak M, Ussowicz M, Dyla A, Chybicka A, Styczyński J, Debski R, Wysocki M, Goździk J, Ratajczak M, Kowalczyk JR: [Megachemotherapy and autologous hematopoietic stem cell transplantation in children with solid tumours excluding neuroblastoma--experience of Polish paediatric centres]. Med Wieku Rozwoj; 2006 Jul-Sep;10(3 Pt 1):785-92
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  • 25 children were treated for Ewing Sarcoma, 13 for rhabdomyosarcoma embryonale (RMS), 7 for germinal tumours, 6 for medulloblastoma, 4 for PNET, 4 for Wilm's tumours, 2 for glioblastoma and single patients with mesenchymoma, astrocytoma, ependymoma, angioblastoma, carcinoma ovarian and carcinoma embryonale glutei.
  • In 29 children MCH was introduced in first complete remission, in 14 the procedure was performed in second or subsequent remission and 24 patients did not achieve remission before megachemotherapy was started.
  • 23 out of 29 (79%) patients were transplanted in first complete remission and median observation time in that group is 29 months (range 2-74 months).
  • 39 patients relapsed at a median time 11 months after MCT and 37 of them subsequently died of disease at a median time of 16 months.
  • It is a safe procedure especially when performed in remission.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hematopoietic Stem Cell Transplantation. Neoplasms / drug therapy. Neoplasms / surgery
  • [MeSH-minor] Academic Medical Centers. Adolescent. Antineoplastic Agents, Alkylating / administration & dosage. Bone Neoplasms / drug therapy. Bone Neoplasms / surgery. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Dose-Response Relationship, Drug. Ependymoma / drug therapy. Ependymoma / surgery. Female. Glioblastoma / drug therapy. Glioblastoma / surgery. Glioma / drug therapy. Glioma / surgery. Humans. Infant. Male. Meningeal Neoplasms / drug therapy. Meningeal Neoplasms / surgery. Meningioma / drug therapy. Meningioma / surgery. Neoplasm Staging. Oncology Service, Hospital. Poland. Remission Induction. Retrospective Studies. Sarcoma, Ewing / drug therapy. Sarcoma, Ewing / surgery. Transplantation, Autologous. Treatment Outcome

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  • (PMID = 17317909.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating
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22. Kurtkaya-Yapícíer O, Scheithauer BW, Dedrick DJ, Wascher TM: Primary epithelioid sarcoma of the dura: case report. Neurosurgery; 2002 Jan;50(1):198-202; discussion 202-3
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  • [Title] Primary epithelioid sarcoma of the dura: case report.
  • CLINICAL PRESENTATION: We present the case of an 18-year-old woman with a unique dural sarcoma that arose in the right frontotemporal region.
  • As visualized on magnetic resonance imaging studies, the 4.5-cm tumor focally traversed the cranium to penetrate the galea, the temporal muscle, and subcutaneous tissue.
  • INTERVENTION: Despite gross total removal and postoperative radiotherapy (59 Gy), a large recurrence was noted 5 months after surgery.
  • CONCLUSION: With the inclusion of epithelioid sarcoma, the spectrum of central nervous system sarcomas continues to expand.
  • [MeSH-major] Dura Mater / surgery. Meningeal Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Microscopy, Electron. Neoplasm Recurrence, Local / drug therapy. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 11852861.001).
  • [ISSN] 0148-396X
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Passarin MG, Vattemi E, Musso AM, Romito S, Moretto G, Ghimenton C, Iuzzolino P, Doglioni C, Pedersini R: Intracranial granulocytic sarcoma after chemotherapy for pineal germinoma and testicular cancer. J Clin Oncol; 2008 Sep 20;26(27):4507-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial granulocytic sarcoma after chemotherapy for pineal germinoma and testicular cancer.
  • [MeSH-major] Brain Neoplasms / diagnosis. Meningeal Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / therapy. Pinealoma / therapy. Sarcoma, Myeloid / diagnosis. Spinal Cord Neoplasms / secondary. Testicular Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Fatal Outcome. Germinoma / diagnosis. Germinoma / therapy. Humans. Male. Neoplasm Staging. Orchiectomy. Remission Induction

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  • (PMID = 18802163.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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24. Vaporciyan AA, Putnam JB Jr, Smythe WR: The potential role of aprotinin in the perioperative management of malignant tumors. J Am Coll Surg; 2004 Feb;198(2):266-78
Hazardous Substances Data Bank. APROTININ .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The potential role of aprotinin in the perioperative management of malignant tumors.
  • [MeSH-major] Aprotinin / therapeutic use. Neoplasms / drug therapy. Serine Proteinase Inhibitors / therapeutic use
  • [MeSH-minor] Animals. Blood Loss, Surgical / prevention & control. Disease Progression. Female. Hemostasis. Humans. Kallikreins / physiology. Kidney / drug effects. Meningeal Neoplasms / surgery. Meningioma / surgery. Mesothelioma / surgery. Neoplasm Invasiveness. Neoplasm Metastasis / prevention & control. Neovascularization, Pathologic / physiopathology. Ovarian Neoplasms / physiopathology. Pneumonectomy. Sarcoma / surgery. Urinary Bladder Neoplasms / surgery. Urokinase-Type Plasminogen Activator / antagonists & inhibitors

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  • (PMID = 14759785.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Serine Proteinase Inhibitors; 9087-70-1 / Aprotinin; EC 3.4.21.- / Kallikreins; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
  • [Number-of-references] 75
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