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Items 1 to 31 of about 31
1. Chang YL, Wu CT, Lee YC: Mediastinal and retroperitoneal teratoma with focal gastrointestinal adenocarcinoma. J Thorac Oncol; 2006 Sep;1(7):729-31
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  • [Title] Mediastinal and retroperitoneal teratoma with focal gastrointestinal adenocarcinoma.
  • We report an unusual case of gastrointestinal adenocarcinoma arising in a giant posterior mediastinal mature cystic teratoma extending into the retroperitoneum, which was treated by complete excision with a good outcome for more than 2 years.
  • Teratomas with malignant transformation are rare non-germ cell malignant tumors arising from a preexisting mature teratoma.
  • Histological examination revealed that the cyst wall was composed of mature ectodermal, mesodermal, and endodermal elements.
  • In this report, we describe the potential aggressiveness of a giant mature cystic teratoma with adenocarcinoma and suggest that complete surgical resection without adjuvant chemotherapy be considered as a therapy in the treatment of teratoma with focal malignant transformation.
  • [MeSH-major] Adenocarcinoma / pathology. Gastrointestinal Neoplasms / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 17409945.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Kumano M, Miyake H, Hara I, Furukawa J, Takenaka A, Fujisawa M: First-line high-dose chemotherapy combined with peripheral blood stem cell transplantation for patients with advanced extragonadal germ cell tumors. Int J Urol; 2007 Apr;14(4):336-8
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  • [Title] First-line high-dose chemotherapy combined with peripheral blood stem cell transplantation for patients with advanced extragonadal germ cell tumors.
  • BACKGROUND: The objective of this study was to evaluate the efficacy and safety of first-line high-dose chemotherapy (HDCT) combined with peripheral blood stem cell transplantation (PBSCT) for patients with advanced extragonadal germ cell tumors (EGGCT).
  • METHODS: Six male patients with advanced non-seminomatous EGGCT were treated with HDCT combined with PBSCT following 2-3 cycles of conventional-dose induction chemotherapy.
  • The regimens used for HDCT were carboplatin, etoposide and ifosfamide (ICE) in five patients and ICE plus paclitaxel (T-ICE) in one patient, and that for induction therapy was cisplatin, etoposide and bleomycin (PEB) in all patients.
  • Five patients underwent surgical resection of residual tumors after HDCT, yielding necrotic tissue in two, mature teratoma in two, and viable cancer tissue in one, and the surgical margin was negative in all patients.
  • Although all patients had grade 3 hematological toxicity, there was no treatment-related death by combining PBSCT.
  • CONCLUSIONS: First-line HDCT with PBSCT could be safely administered to patients with advanced EGGCT, and the antitumor effect of this treatment was comparatively favorable.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Mediastinal Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy. Peripheral Blood Stem Cell Transplantation. Peritoneal Neoplasms / therapy. Retroperitoneal Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Dose-Response Relationship, Drug. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17470166.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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3. Saito J, Takayama H, Kakuta Y, Miyagawa Y, Tsujihata M, Nishimura K, Nonomura N, Okuyama A: [The growing teratoma syndrome report of a case]. Nihon Hinyokika Gakkai Zasshi; 2006 Sep;97(6):796-800
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  • [Title] [The growing teratoma syndrome report of a case].
  • Histopathological examination of the specimen revealed yolk sac tumor and mature teratoma.
  • Further evaluation revealed mediastinal and retroperitoneal lymph node metastases (stage IIIA).
  • A single course of BEP (bleomysin, etoposide and cisplatin), two courses of chemotherapy consisting of nedaplatin and irinotecan, and three courses of TIP (paclitaxel, ifosfamide and cisplatin) were delivered.
  • The previous abnormally elevated serum biomarkers (AFP, beta-hCG and LDH) returned to normal levels, but the mediastinal and retroperitoneal masses continued to enlarge slowly.
  • The CT-guided biopsy of the mediastinal mass was performed, and histologic study revealed no evidence of malignancy.
  • He underwent excision of the mediastinal masses and retroperitoneal lymph node dissection.
  • Histologic examination of the resected specimens revealed mature teratoma without malignant components.
  • These results were compatible with growing teratoma syndrome.
  • 30 months after the first excision of mediastinal mass, he underwent the second excision of recurrent mediastinal mass in the absence of biomarker elevation.
  • The resected specimens revealed mature teratoma without malignant components.
  • [MeSH-major] Endodermal Sinus Tumor. Neoplasms, Multiple Primary. Teratoma. Testicular Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Etoposide / administration & dosage. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Orchiectomy. Remission Induction

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  • (PMID = 17025213.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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4. Popp G, Dragnev K: Secondary malignant transformation of a primary mediastinal germ cell tumor with diffuse lymphangitic spread to the lungs. South Med J; 2003 Jul;96(7):696-8
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  • [Title] Secondary malignant transformation of a primary mediastinal germ cell tumor with diffuse lymphangitic spread to the lungs.
  • Evaluation of the chest with computed tomography revealed a large anterior mediastinal mass and interstitial thickening consistent with lymphangitic spread.
  • Chemotherapy for the germ cell tumor, consisting of etoposide, ifosfamide, and cisplatin, resulted in dramatic clinical improvement and normalization of the beta-human chorionic gonadotropin level.
  • The lymphangitic changes resolved, although the mediastinal mass persisted.
  • A large, anterior mediastinal, mature teratoma, as well as pleural nodules with adenocarcinoma, was excised after completion of chemotherapy.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Lymphatic Metastasis / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Second Primary / pathology. Pleural Neoplasms / secondary. Teratoma / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Chorionic Gonadotropin, beta Subunit, Human / blood. Combined Modality Therapy. Humans. Male. Neoadjuvant Therapy. Pleura / pathology. Pleural Effusion, Malignant / drug therapy. Pleural Effusion, Malignant / pathology. Pleural Effusion, Malignant / surgery. Thoracotomy. Tomography, X-Ray Computed

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  • (PMID = 12940324.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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5. Ondrus D, Hornák M, Breza J, Mat'oska J, Schnorrer M, Belan V, Kausitz J: Delayed orchiectomy after chemotherapy in patients with advanced testicular cancer. Int Urol Nephrol; 2001;32(4):665-7
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  • [Title] Delayed orchiectomy after chemotherapy in patients with advanced testicular cancer.
  • INTRODUCTION: The therapeutic procedures in the management of testicular cancer are determined by histological findings in the removed testis and by the extent of the disease at the time of diagnosis.
  • However, all advanced tumors could be treated by primary chemotherapy regardless of the histological findings.
  • When the diagnosis of advanced tumor is evident, it is possible to start the treatment without orchiectomy.
  • The aim of this study was to evaluate the advantages of neo-adjuvant chemotherapy with delayed orchiectomy in the management of advanced testicular cancer.
  • MATERIAL AND METHODS: A total of 36 patients with advanced germ cell testicular cancer underwent primary PVB or BEP chemotherapy without previous orchiectomy.
  • Eleven patients had a bulky disease in the retroperitoneum (Stage IIC), two had enlarged retroperitoneal lymph nodes (Stage IIB), two had enlarged mediastinal lymph nodes (Stage III) and other 16 patients had also pulmonary metastases, and 5 pts had pulmonary metastases only.
  • The patients were treated with cisplatin-containing combination chemotherapy.
  • Following completion of chemotherapy, orchiectomy was performed alone or simultaneously with retroperitoneal lymph node dissection (RPLND) and/or lung metastasectomy in cases with persistent residual mass.
  • Following orchiectomy the patients were regularly checked and in cases with viable malignant tumor found in the testis sequential chemotherapy was administered.
  • Similarly when the relapse of the disease was detected, the patients were treated with sequential chemotherapy.
  • RESULTS: Complete disappearance of metastases was observed in 12 patients following chemotherapy alone.
  • The viable tumor in the removed tissue was found in one patient.
  • Delayed orchiectomy was performed simultaneously with surgical removal of residual mass in the retroperitoneum in 24 patients and as a separate procedure in 12 patients who have been considered to be complete responders following chemotherapy alone.
  • Residual viable tumor in testicular specimen was found in three patients, necrotic or fibrotic tissue in 18, and mature teratoma in 15 patients.
  • Overall survival of the patients was 26/36 (72.7%) at mean of 56.9 months (range 7-145 months, median 50 months) since the start of the treatment.
  • CONCLUSIONS: In patients with advanced germ cell testicular cancer preference must be given to the early beginning of intensive chemotherapy without the need of tissue diagnosis of primary tumor that should be obtained by orchiectomy.
  • Benefit of this therapeutic approach is the timely management of acute abdominal and/or pulmonary symptoms of life-threatening distant metastases.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / therapeutic use. Cisplatin / therapeutic use. Germinoma / drug therapy. Orchiectomy. Testicular Neoplasms / drug therapy. Vinblastine / therapeutic use
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm, Residual. Survival Rate. Teratoma / secondary. Time Factors. Treatment Outcome

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  • [Cites] J Clin Oncol. 1984 Sep;2(9):1025-7 [6088708.001]
  • [Cites] J Urol. 1983 Mar;129(3):522-3 [6834536.001]
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  • (PMID = 11989561.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; PVB protocol
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6. Miwa K, Taniguchi Y, Adachi Y, Haruki T, Nakamura H: [Huge mediastinal mature teratoma with combined resection of adjacent structures; report of a case]. Kyobu Geka; 2006 Nov;59(12):1115-8
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  • [Title] [Huge mediastinal mature teratoma with combined resection of adjacent structures; report of a case].
  • We report a case of a 64-year-old woman with an anterior mediastinal tumor on a chest computed tomography (CT) before operation of uterine cancer.
  • After the radical surgery and a chemotherapy for uterine cancer, surgical resection of mediastinal tumor was performed in July 2005 because of gradually progression in tumor size.
  • Histologically, the tumor was diagnosed as a mature teratoma with the tissue of bone, digestive tract epithelium, bronchial epithelium and so on.
  • In benign teratoma, it is not rare to perforate to the adjacent structures.
  • So, we concluded if the mediastinal teratoma was suspected, long-term observation had the risk for adhesion and perforation to adjacent tissue, and in case of operation, we should keep in mind the possibility of combined resection of involved organs.
  • [MeSH-major] Brachiocephalic Veins / surgery. Lung Diseases / surgery. Mediastinal Neoplasms / surgery. Teratoma / surgery
  • [MeSH-minor] Female. Humans. Middle Aged. Thoracotomy / methods. Tissue Adhesions

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  • (PMID = 17094553.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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7. Hsiao HH, Liu YC, Tsai HJ, Tsai KB, Cheng YJ, Chou SH, Chong IW, Yang WC, Liu TC, Lin SF: Poor outcomes in patients with primary malignant mediastinal germ-cell tumors. Kaohsiung J Med Sci; 2005 Dec;21(12):561-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Poor outcomes in patients with primary malignant mediastinal germ-cell tumors.
  • Primary mediastinal germ-cell tumors (GCTs) without gonadal involvement are rare and can be divided into benign mature teratoma and malignant seminoma or nonseminoma.
  • We describe our experience of malignant mediastinal GCTs and compare the presentations and outcome with those of benign teratomas.
  • The patient with seminoma was treated with surgery and radiation, while those with nonseminoma tumors were treated with chemotherapy and/or surgery.
  • These cases highlight the important role of disease staging and tumor-marker levels in malignant GCTs, and suggest that new treatment strategies for malignant GCTs await further investigation.
  • [MeSH-major] Mediastinal Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Infant. Male. Retrospective Studies. Survival Rate. Treatment Outcome. alpha-Fetoproteins / analysis

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  • (PMID = 16670048.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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8. Funahashi M, Tuchiya F, Makiyama K, Sugiura S, Miyoshi Y, Kishida T, Ogawa T, Uemura H, Yao M, Kubota Y: [Two cases of testicular tumors with high alpha-fetoprotein levels: a case report]. Hinyokika Kiyo; 2005 Feb;51(2):133-7
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  • In 2002, chemotherapy was performed for a metastatic seminoma revealed as a solitary mass in the mediastinum by radiographic studies, and histologically confirmed to be a metastatic seminoma.
  • Case 2: In 2002, a 30-year-old male underwent left high orchiectomy for a left testicular tumor, and histological examination revealed seminoma, immature and mature teratoma, embryonal carcinoma.
  • After 2 courses of chemotherapy, the serum AFP remained at an abnormally high concentration.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Embryonal / diagnosis. Neoplasms, Multiple Primary / diagnosis. Seminoma / diagnosis. Teratoma / diagnosis. Testicular Neoplasms / diagnosis. alpha-Fetoproteins / analysis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Disease-Free Survival. Follow-Up Studies. Humans. Male. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / secondary. Orchiectomy

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  • (PMID = 15773370.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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9. Yoshioka M, Mori T, Okuma T, Kitamura N, Ito N, Nishi K: Mediastinal growing teratoma syndrome. Jpn J Thorac Cardiovasc Surg; 2000 Jan;48(1):66-8
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  • [Title] Mediastinal growing teratoma syndrome.
  • A 27-year-old man had undergone orchiectomy and chemotherapy for testicular cancer.
  • Despite normalization of raised tumor marker levels after postoperative chemotherapy, computed tomographic scanning demonstrated multiple swellings of the para-aortic lymph nodes with extension from beneath the aortic arch to the bifurcation of the descending aorta.
  • Open biopsies of the para-aortic lymph nodes disclosed mature teraroma without malignant cells.
  • The patient presented the typical features of mediastinal and retroperitoneal growing teratoma syndrome.
  • Histological examination of the resected specimens revealed a mature teratoma component without malignant cells.
  • [MeSH-major] Mediastinal Neoplasms / surgery. Neoplasms, Second Primary. Teratoma / surgery
  • [MeSH-minor] Adult. Follow-Up Studies. Germinoma / drug therapy. Germinoma / surgery. Humans. Male. Orchiectomy. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery. Syndrome. Testicular Neoplasms / drug therapy. Testicular Neoplasms / surgery. Treatment Outcome

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  • (PMID = 10714023.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
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10. Yatsuyanagi E, Kusajima K, Suzuki M, Hirano T, Sakurada T, Kikuchi Y, Sugawara Y: [Induction chemotherapy and radical resection for primary nonseminomatous mediastinal germ cell tumor (NSGCT); report of a case]. Kyobu Geka; 2004 Feb;57(2):168-71
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  • [Title] [Induction chemotherapy and radical resection for primary nonseminomatous mediastinal germ cell tumor (NSGCT); report of a case].
  • A 15-year-old male was admitted to our hospital for treatment of an anterior mediastinal tumor.
  • Computed tomography (CT) revealed a heterogeneous solid tumor located in the anterior mediastinum.
  • We believed this tumor to be nonseminomatous mediastinal germ cell tumor (NSGCT) and started intensive chemotherapy with cisplatin (CDDP) without histologic diagnosis because his serum AFP level was rapidly increasing.
  • After 2 courses of chemotherapy, his serum AFP level returned to the normal range and surgical resection of the tumor with part of right lung was performed.
  • Histopathological examination revealed that the tumor consisted of mature teratoma and yolk sac tumor.
  • He underwent 1 course of chemotherapy post-operatively because a small number of viable cells were histopathologically recognized in the yolk sac component.
  • At the time of writing, the patient is alive without any evidence of recurrence.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / surgery. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / surgery. Neoplasms, Multiple Primary. Teratoma / drug therapy. Teratoma / surgery
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Humans. Male. Perioperative Care. Treatment Outcome

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  • (PMID = 14978917.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin
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11. Iyoda A, Hiroshima K, Yusa T, Toyozaki T, Fujisawa T, Ohwada H: The primary mediastinal growing teratoma syndrome. Anticancer Res; 2000 Sep-Oct;20(5C):3723-6
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  • [Title] The primary mediastinal growing teratoma syndrome.
  • We encountered a case of mediastinal immature teratoma which revealed the feature of the so-called growing teratoma syndrome.
  • A 20-year-old male with a cough was discovered to have an abnormal shadow in the mediastinum.
  • The specimen with percutaneous needle biopsy revealed mature teratoma.
  • The tumor was suspected to be mature teratoma with a malignant component because of the high level of serum AFP and he underwent chemotherapy.
  • The resected tumor was diagnosed as immature teratoma, although most of the tumor tissue was mature component.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Carboplatin / administration & dosage. Cisplatin / administration & dosage. Cough. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Humans. Magnetic Resonance Imaging. Male. Radiography, Thoracic. Syndrome. Treatment Outcome. alpha-Fetoproteins / analysis

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  • (PMID = 11268445.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / alpha-Fetoproteins; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 5
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12. Rick O, Bokemeyer C, Weinknecht S, Schirren J, Pottek T, Hartmann JT, Braun T, Rachud B, Weissbach L, Hartmann M, Siegert W, Beyer J: Residual tumor resection after high-dose chemotherapy in patients with relapsed or refractory germ cell cancer. J Clin Oncol; 2004 Sep 15;22(18):3713-9
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  • [Title] Residual tumor resection after high-dose chemotherapy in patients with relapsed or refractory germ cell cancer.
  • PURPOSE: To assess the role of residual tumor resection performed after high-dose chemotherapy (HDCT) in patients with relapsed or refractory germ cell tumors (GCT).
  • PATIENTS AND METHODS: Between July 1987 and October 1999, postchemotherapy resections of residual tumors were performed in 57 patients who had been treated with HDCT for relapsed or refractory GCT and who had achieved a partial remission to this treatment.
  • Necrosis was found in 22 (38%) of 57 patients, mature teratoma with or without necrosis was found in nine (16%) of 57 patients, and viable cancer with or without additional necrosis or mature teratoma was found in 26 (46%) of 57 patients.
  • Patients with viable cancer had a significantly inferior outcome after surgery compared with patients with necrosis and/or mature teratoma even if all cancer was completely resected.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / surgery. Neoplasm, Residual / surgery. Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Germ Cell and Embryonal / surgery. Retroperitoneal Neoplasms / drug therapy. Retroperitoneal Neoplasms / surgery. Testicular Neoplasms / drug therapy. Testicular Neoplasms / surgery

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  • (PMID = 15365067.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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13. Ohtsuka M, Satoh H, Inoue M, Yazawa T, Yamashita YT, Sekizawa K, Hasegawa S: Disseminated metastasis of neuroblastomatous component in immature mediastinal teratoma: a case report. Anticancer Res; 2000 Jan-Feb;20(1B):527-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disseminated metastasis of neuroblastomatous component in immature mediastinal teratoma: a case report.
  • A 17-year-old man with high levels of serum AFP and hCG was diagnosed as having primary mediastinal GCT.
  • Cisplatin-based chemotherapy decreased the biomarkers, but the mass showed further growth.
  • Pathological examination of the resected mass revealed a mixture of immature and mature teratomas.
  • A disseminated metastasis of neuroblastoma in immature mediastinal teratoma is a rare complication.
  • [MeSH-major] Brain Neoplasms / secondary. Lung Neoplasms / secondary. Mediastinal Neoplasms / pathology. Neuroblastoma / secondary. Teratoma / pathology. Thymus Neoplasms / pathology
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Bleomycin / administration & dosage. Cell Lineage. Cisplatin / administration & dosage. Combined Modality Therapy. Disease Progression. Fatal Outcome. Humans. Male. Phosphopyruvate Hydratase / analysis. Skull Neoplasms / pathology. Skull Neoplasms / secondary. Vinblastine / administration & dosage


14. Rygl M, Snajdauf J, Zeman L, Kodet R, Drahokoupilová E, Cumlivská E: [Mediastinal teratomas in children]. Rozhl Chir; 2001 Dec;80(12):624-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mediastinal teratomas in children].
  • The objective of the work is a clinical and histopathological retrospective study of rare mediastinal teratomas in children.
  • The authors present their experience with the treatment of eight children within the range from neonates to the age of 15 years with a histologically confirmed diagnosis of mediastinal teratoma.
  • Four tumors were histologically classified as mature teratomas, three as differentiated teratomas with an immature component and one as a malignant teratoma.
  • The malignant teratoma contained mature tissues as well as tissues of embryonic carcinoma and a yolk sac tumor.
  • Seven children with a mature or differentiated teratoma are without signs of disease 5-15 years after surgery.
  • During the follow-up of the 15-year-old boy with the malignant teratoma the elevated alpha-fetoprotein serum level was evidence of a relapse of the disease after termination of comprehensive treatment.
  • From the results ensues that radical extirpation is sufficient treatment for mature and differentiated teratomas.
  • Malignant teratomas are indicated for primary resection and postoperative chemotherapy.
  • [MeSH-major] Mediastinal Neoplasms. Teratoma

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  • (PMID = 11828658.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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15. Omezzine N, Khouatra C, Larivé S, Freyer G, Isaac-Pinet S, Gérinière L, Droz JP, Souquet PJ: Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report. Ann Oncol; 2002 Feb;13(2):323-6
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  • [Title] Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report.
  • We report a case of rhabdomyosarcoma which occurred in a mediastinal teratoma in a 44-year-old man.
  • Diagnosis was fortuitous, performed by the histological and immunohistochemical study of a mediastinal tumour biopsy specimen that showed embryonal carcinoma and yolk sac tumour components associated with the rhabdomyosarcoma.
  • After cisplatin-based chemotherapy (bleomycin-etoposide-cisplatin), surgical resection of the residual mediastinal tumour was performed.
  • Histological and immunohistochemical study of this tumour confirmed the presence of mature teratoma and embryonal rhabdomyosarcoma.
  • Evolution was marked by a local extension of the mediastinal tumour, occurrence of multiple metastases and bone marrow involvement.
  • The patient died 8 months after diagnosis despite chemotherapy and radiotherapy.
  • A review of the literature reveals that the development of rhabdomyosarcoma in primary mediastinal teratomas is unusual in adults.
  • The diagnostic, therapeutic and prognostic implications of such an association are reviewed.

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  • (PMID = 11886012.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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16. Chen CK, Chang YL, Jou ST, Tseng YT, Lee YC: Treatment of mediastinal immature teratoma in a child with precocious puberty and Klinefelter's syndrome. Ann Thorac Surg; 2006 Nov;82(5):1906-8
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  • [Title] Treatment of mediastinal immature teratoma in a child with precocious puberty and Klinefelter's syndrome.
  • Teratoma is the most common germ cell tumor, which can be divided into the mature and the immature histologically.
  • In reviewing the literature on the subject, the role of neoadjuvant and adjuvant chemotherapy remains ill-defined for the immature teratoma.
  • We share the experience of treating a child with immature teratoma with surgical excision alone, and it ended in a local recurrence.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Klinefelter Syndrome / complications. Mediastinal Neoplasms / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Bleomycin / therapeutic use. Child, Preschool. Cisplatin / therapeutic use. Combined Modality Therapy. Etoposide / therapeutic use. Humans. Male. Neoplasm Recurrence, Local. Puberty, Precocious / etiology. Reoperation


17. Aoyama A, Bando T, Okubo K, Wada H: [Current strategy for primary mediastinal germ cell tumors]. Nihon Geka Gakkai Zasshi; 2006 Nov;107(6):284-7
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  • [Title] [Current strategy for primary mediastinal germ cell tumors].
  • Mediastinal germ cell tumor (MGCT) is histologically similar to, but is different from that in gonad glands.
  • As to therapy, mature teratoma can be cured by resection alone.
  • But cisplatin-based chemotherapy, often together with resection and radiation, has been playing a primary role in managing malignant MGCT consisting of seminoma and non-seminomatous MGCT.
  • Treatment decisions should be based on the available evidence mainly obtained by retrospective studies because of the rarity of the entity.
  • Seventeen of 18 patients with malignant MGCT survived after surgery with cisplatin-based chemotherapy, while only 3 of 12 survived before cisplatin was introduced.
  • In non-seminomatous MGCT, we now adopt cisplatin-based chemotherapy followed by surgery, including high-dose chemotherapy with peripheral blood stem cell transplantation to obtain the normalization of tumor markers.
  • Additional chemotherapy is considered, if viable cells are found in resected specimen.
  • [MeSH-major] Mediastinal Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy. Thoracic Surgical Procedures
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Humans. Male. Peripheral Blood Stem Cell Transplantation. Retrospective Studies

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  • (PMID = 17147288.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
  • [Number-of-references] 17
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18. Völkl TM, Langer T, Aigner T, Greess H, Beck JD, Rauch AM, Dörr HG: Klinefelter syndrome and mediastinal germ cell tumors. Am J Med Genet A; 2006 Mar 1;140(5):471-81
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  • [Title] Klinefelter syndrome and mediastinal germ cell tumors.
  • However, there is an increased incidence of mediastinal germ cell tumors (M-GCT) in KS, whereas the discussion of a generally higher tumor risk in this condition is still controversial.
  • Laboratory analyses (suppressed gonadotropins, elevated testosterone) and thoracic CT demonstrated a beta-human chorionic gonadotropin (beta-hCG) and alpha(1)-feto protein (alpha-FP) secreting mediastinal tumor.
  • Histological analysis showed a mixed germ cell tumor comprising choriocarcinoma (CH), embryonal carcinoma (EC), mature teratoma (MT), and yolk sac tumor (YS).
  • He was successfully treated by surgery and adjuvant chemotherapy.
  • There is still no convincing explanation for the association of M-GCTs and KS.
  • [MeSH-major] Klinefelter Syndrome / complications. Mediastinal Neoplasms / complications. Neoplasms, Germ Cell and Embryonal / complications. Puberty, Precocious / complications

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  • (PMID = 16470792.001).
  • [ISSN] 1552-4825
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Kobayashi N, Koizumi T, Eguchi T, Hyogotani A, Saito G, Hamanaka K, Shiina T, Kurai M, Kondo R, Yoshida K, Amano J: A mediastinal somatic-type germ cell tumor with hepatic metastasis successfully treated by multiple modalities. Anticancer Res; 2010 Dec;30(12):5117-20
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  • [Title] A mediastinal somatic-type germ cell tumor with hepatic metastasis successfully treated by multiple modalities.
  • Rhabdomyosarcoma in the mediastinum coexisting with metastatic non-seminomatous germ cell tumor, so-called somatic-type malignancy, is a rare carcinoma and has poor survival.
  • This study reports a case of diffuse and huge hepatic metastasis of non-seminomatous germ cell tumor associated with coexisting embryonal rhabdomyosarcoma in the mediastinum.
  • A 31-year-old man presented with abdominal pain and was found to have multiple abnormal hepatic masses on abdominal computed tomography (CT).
  • Concomitantly, an anterior mediastinal mass was found on chest CT.
  • Chemotherapy was initiated because the hepatic lesion was diagnosed as choriocarcinoma, based on histological findings and the elevation of chorionic gonadotropin β-subunit and α-fetoprotein.
  • After six cycles of bleomycin, etoposide and cisplatin chemotherapy the metastatic liver tumors showed complete response.
  • The remaining mediastinal tumor was completely and successfully resected.
  • The histological findings revealed mature teratoma with embryonal rhabdomyosarcoma.
  • The patient has remained well for over six years after the treatment without any signs of disease recurrence.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / drug therapy. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Mediastinal Neoplasms / drug therapy. Rhabdomyosarcoma, Embryonal / drug therapy. Teratoma / drug therapy

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  • (PMID = 21187499.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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20. Chetaille B, Massard G, Falcoz PE: [Mediastinal germ cell tumors: anatomopathology, classification, teratomas and malignant tumors]. Rev Pneumol Clin; 2010 Feb;66(1):63-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mediastinal germ cell tumors: anatomopathology, classification, teratomas and malignant tumors].
  • Mediastinal germ cell tumors are rare tumors.
  • It is classic to divide those tumors into two categories, seminomas and nonseminomatous germ cell tumors: teratomas (mature or immature), embryonal carcinomas, yolk sac tumors, and choriocarcinomas.
  • Each histological sub-type can be associated to another sub-type that realise a so-called mixed germ cell tumor.
  • Diagnosis strategy is currently well codified for malignant mediastinal germ cell tumors.
  • For instance, the treatment strategy still raises some specific problems to each histological type.
  • The treatment of seminomatous tumors is standardised--chemotherapy/surgery on residual tumor greater than 3 cm/radiotherapy on viable persistent residual tumors--and provides very satisfying results.
  • The treatment strategy is less standardised--association of chemotherapy and surgery--and the prognosis is very severe.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Combined Modality Therapy. Humans. Mediastinum / pathology. Neoplasm Invasiveness. Prognosis. Seminoma / classification. Seminoma / pathology. Seminoma / therapy. Teratoma / classification. Teratoma / pathology. Teratoma / therapy. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20207298.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 18
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21. Koga H, Yamataka A, Kobayashi H, Miyamoto H, Lane GJ, Miyano T: Median sternotomy provides excellent exposure for excising anterior mediastinal tumors in children. Pediatr Surg Int; 2005 Nov;21(11):864-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Median sternotomy provides excellent exposure for excising anterior mediastinal tumors in children.
  • Median sternotomy (M-S) provides excellent exposure and allows dissection of the medial side of an anterior mediastinal tumor (AMT) with minimal risk.
  • AMT were resected completely in all cases through M-S with the patient in the supine position.
  • There were dense adhesions between AMT and important mediastinal structures such as the anterior part of the pericardium (cases 1 and 2), left phrenic nerve (case 3), and pulmonary vessels (case 4, 5), but all were dissected safely under direct vision.
  • There was no respiratory or cardiovascular compromise during M-S due to compression of the healthy lung and mediastinum.
  • Histopathologic findings were mature teratoma in cases 1, 3, and 5, immature teratoma in case 2, and pleuropulmonary blastoma in case 4.
  • After mean follow-up of 3.4 years, cases 1, 2, 3, and 5 are currently well with no signs of recurrence, but case 4 died from disseminated intravascular coagulation during postoperative chemotherapy for massive local tumor recurrence 6 months after surgery.
  • [MeSH-major] Mediastinal Neoplasms / surgery. Sternum / surgery
  • [MeSH-minor] Child. Child, Preschool. Female. Humans. Infant. Male. Osteotomy. Teratoma / surgery. Tomography, X-Ray Computed

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  • [Cites] Pediatr Surg Int. 1998 Oct;13(8):560-3 [9799375.001]
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  • (PMID = 16133516.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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22. Hiroshima K, Toyozaki T, Iyoda A, Yusa T, Fujisawa T, Ohwada H: Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum. Cancer; 2001 Oct 1;92(7):1798-806
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  • [Title] Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum.
  • BACKGROUND: Mediastinal teratomas are the most frequent mediastinal germ cell tumor.
  • Whereas mature teratomas are benign tumors, immature teratomas are malignant.
  • The purpose of this study was to find characteristics that could be used to distinguish between the growth and prognosis of the two teratoma types.
  • METHODS: Twenty-four mediastinal teratomas (18 mature and 6 immature) were examined for apoptosis by 3'-end labeling of DNA and stained immunohistochemically for proliferating cell nuclear antigen, Bcl-2, Bax, p53 protein, and alpha-fetoprotein (AFP) expression in formalin fixed, paraffin embedded specimens.
  • RESULTS: AFP was expressed in both immature teratomas and mature teratomas.
  • Whereas p53 protein was expressed by most teratomas, p53 gene mutation was observed in only one patient with an immature teratoma in which the same mutation occurred in all tumor tissue components tested.
  • Bax protein expression was relatively diffuse in mature teratomas but was focally expressed in immature teratomas.
  • Bcl-2 protein was expressed focally in both mature and immature teratomas.
  • Although the proliferative index was significantly higher in immature teratomas compared with mature teratomas (P < 0.001), the apoptotic index (AI) was significantly higher in mature teratomas compared with immature teratomas (P < 0.05).
  • CONCLUSIONS: The relatively high AI in mature teratomas may be due to the overexpression of the p53 protein.
  • However, patients with immature mediastinal teratomas have a good prognosis if the tumor is resected completely after chemotherapy.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Teratoma / pathology

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  • [Copyright] Copyright 2001 American Cancer Society.
  • (PMID = 11745252.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / DNA, Neoplasm; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / alpha-Fetoproteins; 0 / bcl-2-Associated X Protein
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23. Murakawa T, Nakajima J, Kohno T, Tanaka M, Takeuchi E, Oka T, Takamoto S: [Primary mediastinal germ cell tumor: report of a case]. Kyobu Geka; 2000 Apr;53(4):345-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary mediastinal germ cell tumor: report of a case].
  • An anterior mediastinal tumor, 13 cm in diameter, was pointed out on chest X-ray.
  • The tumor was diagnosed as primary mediastinal germ cell tumor with mixed seminomatous and non-seminomatous elements due to elevated serum AFP and beta HCG, and the pathological finding of needle biopsy specimen.
  • He underwent 3 courses of chemotherapy with BEP regimen, and following surgical resection of the tumor, left upper lobectomy and partial resection of pericardium via median sternotomy.
  • Pathological diagnosis of the resected tumor was mature cystic teratoma.
  • [MeSH-major] Germinoma / therapy. Mediastinal Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Humans. Male. Middle Aged

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  • (PMID = 10770066.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] JAPAN
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24. De Backer A, Madern GC, Hakvoort-Cammel FG, Oosterhuis JW, Hazebroek FW: Mediastinal germ cell tumors: clinical aspects and outcomes in 7 children. Eur J Pediatr Surg; 2006 Oct;16(5):318-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal germ cell tumors: clinical aspects and outcomes in 7 children.
  • BACKGROUND: Mediastinal germ cell tumors presenting during childhood are extremely rare.
  • This paper reports on the clinical presentations, method(s) of treatment, complications, results and outcomes in a series of children with mediastinal germ cell tumors.
  • METHODS: A retrospective chart review of 7 children treated between 1971 and 2001 for mediastinal germ cell tumor was carried out.
  • Each patient's surgical treatment, peri- and postoperative complications, histological staging and final outcome were analysed.
  • Four patients had histologically benign tumors (mature teratoma).
  • Their sole treatment consisted of complete surgical excision of the tumor and (part of) the thymus using either median sternotomy or left-sided thoracotomy.
  • All four are alive with no evidence of disease, between 2.5 and 29 years after treatment.
  • Malignant tumors were observed in three patients (1 yolk sac tumor, 1 choriocarcinoma and 1 malignant teratoma).
  • Treatment consisted of either biopsy or debulking followed by chemotherapy (and radiotherapy in 1 case).
  • CONCLUSIONS: Both this study and the literature review testify to the extreme rarity of mediastinal germ cell tumors in childhood.
  • Children with this type of tumor usually are severely symptomatic.
  • However, the use of platinum-based combination chemotherapy has considerably increased the survival rates.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Male. Prognosis. Retrospective Studies. Teratoma / diagnosis. Teratoma / surgery. Treatment Outcome

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  • (PMID = 17160775.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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25. Ishibashi H, Shimoyama T, Akamatsu H, Sunamori M, Ohtani T, Imai K: [A successfully resected case of giant malignant mediastinal germ cell tumor]. Kyobu Geka; 2002 Aug;55(9):815-8
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  • [Title] [A successfully resected case of giant malignant mediastinal germ cell tumor].
  • Histological findings of the specimens obtained by needle biopsy revealed a mature teratoma with non-seminoma.
  • After 2 courses of chemotherapy [cisplatin (CDDP) and etoposide (VP-16)], serum AFP level decreased to 25 ng/ml, and the tumor was resected with pericardium (the tumor size was 14 x 10 x 20 cm).
  • Two courses of chemotherapy were administered again postoperatively with normalization of serum AFP level.
  • [MeSH-major] Germinoma / surgery. Mediastinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Humans. Male. Treatment Outcome. alpha-Fetoproteins / analysis

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  • (PMID = 12174631.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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26. Takeda S, Miyoshi S, Ohta M, Minami M, Masaoka A, Matsuda H: Primary germ cell tumors in the mediastinum: a 50-year experience at a single Japanese institution. Cancer; 2003 Jan 15;97(2):367-76

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary germ cell tumors in the mediastinum: a 50-year experience at a single Japanese institution.
  • BACKGROUND: Primary germ cell tumors (GCT) of the mediastinum share similar clinical and biologic characteristics, which are different from their testicular counterpart.
  • The purpose of the current study was to review the authors' institutional experience of mediastinal GCT, emphasizing the clinical spectrum, time trends of treatment, and recent advances in therapeutic modalities for malignant GCT.
  • METHODS: Between 1951 and 2000, 129 patients (70 males and 59 females) underwent surgical treatment for GCT, which accounted for 16.0% of the mediastinal tumors during the same period.
  • There were 95 patients with mature teratomas, 13 patients with seminomas, and 21 patients with nonseminomatous germ cell tumors (NSGCT) with median ages of 26.4 years, 27.6 years, and 28.5 years, respectively.
  • RESULTS: Adult patients with mature teratomas were less symptomatic (33.3%) than pediatric patients (52.4%).
  • All patients with mature teratoma were cured by resection alone.
  • Eight of the 13 patients (61.5%) with seminoma were symptomatic and 10 of 13 patients (83.3%) survived after surgery and radiation with/without chemotherapy.
  • After 1986, six of eight patients received cisplatin-based chemotherapy, including three who received additional high-dose chemotherapy with a supporting peripheral blood stem cell transplantation until tumor markers normalized.
  • CONCLUSIONS: The institutional experience indicates the benign nature of mediastinal mature teratomas and the excellent prognosis for patients with seminomas after resection.
  • An improved survival advantage was ensured with cisplatin-based preoperative chemotherapy in patients with NSGCT.
  • [MeSH-major] Mediastinal Neoplasms. Neoplasms, Germ Cell and Embryonal
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Infant. Japan. Male. Middle Aged. Seminoma / diagnosis. Seminoma / epidemiology. Seminoma / therapy. Survival Analysis. Teratoma / diagnosis. Teratoma / epidemiology. Teratoma / therapy

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  • [Copyright] Copyright 2003 American Cancer Society
  • (PMID = 12518361.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Jeung MY, Gasser B, Gangi A, Bogorin A, Charneau D, Wihlm JM, Dietemann JL, Roy C: Imaging of cystic masses of the mediastinum. Radiographics; 2002 Oct;22 Spec No:S79-93
MedlinePlus Health Information. consumer health - Abscess.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of cystic masses of the mediastinum.
  • Cystic masses of the mediastinum are well-marginated round lesions that contain fluid and are lined with epithelium.
  • Major cystic masses include congenital benign cysts (ie, bronchogenic, esophageal duplication, neurenteric, pericardial, and thymic cysts), meningocele, mature cystic teratoma, and lymphangioma.
  • Many tumors (eg, thymomas, Hodgkin disease, germ cell tumors, mediastinal carcinomas, metastases to lymph nodes, nerve root tumors) can undergo cystic degeneration-especially after radiation therapy or chemotherapy-and demonstrate mixed solid and cystic elements at computed tomography (CT) or magnetic resonance (MR) imaging.
  • A mediastinal abscess or pancreatic pseudocyst also appears as a fluid-containing mediastinal cystic mass.
  • Familiarity with the radiologic features of mediastinal cystic masses facilitates accurate diagnosis, differentiation from other cystlike lesions, and, thus, optimal patient treatment.
  • [MeSH-major] Abscess / diagnosis. Cysts / diagnosis. Mediastinal Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Lymphangioma / diagnosis. Magnetic Resonance Imaging. Male. Meningocele / diagnosis. Meningocele / radiography. Neurilemmoma / diagnosis. Neurilemmoma / radiography. Teratoma / diagnosis. Tomography, X-Ray Computed

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  • [Copyright] Copyright RSNA, 2002
  • (PMID = 12376602.001).
  • [ISSN] 0271-5333
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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28. Pectasides D, Pectasides E, Papaxoinis G, Xiros N, Kamposioras K, Tountas N, Economopoulos T: Methotrexate, paclitaxel, ifosfamide, and cisplatin in poor-risk nonseminomatous germ cell tumors. Urol Oncol; 2010 Nov-Dec;28(6):617-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The efficacy and tolerability of M-TIP was evaluated as first-line treatment for patients with poor-risk germ cell tumors (GCT), according to International Germ Cell Cancer Collaborative Group (IGCCCG) criteria.
  • PATIENTS AND METHODS: Thirty patients with poor-risk GCT were treated with M-TIP (methotrexate 250 mg/m(2) given as a 4-hour infusion with folinic acid rescue on day 1, paclitaxel 175 mg/m(2) given as a 3-hour infusion on day 1, followed by ifosfamide 1.2 g/m(2) given as a 2-hour infusion and cisplatin 20 mg/m(2) given as a 2-hour infusion on days 2 to 6) regimen for four cycles.
  • RESULTS: Five (16.6%, 95% confidence interval [CI]: 2%-31%) patients achieved clinical complete response (cCR) with chemotherapy only, 15 (50%, 95% CI: 31-69%) patients pathologic complete response (pCR) (11 had necrosis/fibrosis and 4 had mature teratoma) and 3 (10%) patients surgical complete response (sCR) for an overall favorable response of 76.6%.
  • Neurotoxicity and nephrotoxicity were not a problem, since only 6.6% and 3.3% of patients developed sensory neuropathy and renal toxicity, respectively.
  • CONCLUSION: M-TIP is a highly effective (high proportion of patients achieved long-term disease-free status, lack of relapses) and well tolerated regimen for first-line treatment of poor-risk GCT patients.
  • These results have to be compared with the standard BEP chemotherapy or more intensive regimens in multicentre randomized trials.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Mediastinal Neoplasms / drug therapy. Neoplasms, Germ Cell and Embryonal / drug therapy. Testicular Neoplasms / drug therapy

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19110454.001).
  • [ISSN] 1873-2496
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate
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29. Yano M, Fujii Y: [Results of surgical treatment for pimary germcell tumors of the mediastinum]. Nihon Geka Gakkai Zasshi; 2006 Nov;107(6):278-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Results of surgical treatment for pimary germcell tumors of the mediastinum].
  • Primary germ cell tumors of the mediastinum are relatively rare with complicated backgrounds including various pathology with mixed types and characteristics.
  • The primary treatment for mature teratoma is surgical resection.
  • In elderly patients, mature teratomas possibly involve epithelial malignant transformation.
  • Cisplatin-based chemotherapy plays an important role in the treatment of both seminoma and nonseminoma.
  • Cases with pleural dissemination or metastasis also have a worse prognosis, with a median survival time of 5 months.
  • The reasons for the poor prognosis in nonseminoma are the inclusion of patients in whom chemotherapy is not effective and those with advanced disease with metastasis.
  • It would be possible to improve the prognosis with the establishment of a standard treatment regimen, development of new agents for the treatment of tumors resistant to current chemotherapy regimens, and detection of more tumors in the early stage.
  • [MeSH-major] Mediastinal Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Child. Child, Preschool. Cisplatin / therapeutic use. Female. Humans. Infant. Japan. Male. Middle Aged. Prognosis. Survival Rate. Time Factors

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  • (PMID = 17147287.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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30. Nishida T, Nishiyama N, Inoue K, Kawata Y, Ichikawa T, Tsukioka T, Wakasa T, Wakasa K, Suehiro S: Successful resection of massively enlarged residual pulmonary metastases from a nonseminomatous germ cell testicular tumor. Osaka City Med J; 2006 Dec;52(2):87-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 25-year-old man was referred to our hospital in June 2000 for treatment of massive enlargement of residual pulmonary metastases from a nonseminomatous germ cell testicular tumor.
  • He had undergone right orchiectomy followed by cisplatin-based combination chemotherapy 7 years ago.
  • Chest radiography and computed tomography showed complete opacification of the left hemithorax with mediastinal shift to the right, and two smaller nodules in the right lung.
  • After salvage chemotherapy, elevated serum alpha-fetoprotein concentrations decreased to the normal range.
  • Postoperative pathologic examination disclosed metastatic germ cell tumors composed of mature teratoma.
  • When technically possible, resection of even massive pulmonary metastases after a favorable response to chemotherapy for a nonseminomatous germ cell tumor, can provide pathologic assessment of the response and offer patients a chance of long-term survival.

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  • (PMID = 17330397.001).
  • [ISSN] 0030-6096
  • [Journal-full-title] Osaka city medical journal
  • [ISO-abbreviation] Osaka City Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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31. Malagón HD, Valdez AM, Moran CA, Suster S: Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol; 2007 Sep;31(9):1356-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Twenty-three tumors arose in the mediastinum, 2 in the retroperitoneum, and 21 in the gonads.
  • The germ cell component consisted of pure mature or immature teratoma (23 cases), teratoma mixed with other seminomatous or nonseminomatous components (17), pure seminoma (2), intratubular germ cell neoplasia (1), and yolk sac tumor (1).
  • All patients were treated by cisplatinum-based chemotherapy plus other agents followed by surgery.
  • [MeSH-major] Immunohistochemistry. Mediastinal Neoplasms / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Ovarian Neoplasms / diagnosis. Retroperitoneal Neoplasms / diagnosis. Sarcoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Orchiectomy. Ovariectomy. Time Factors. Treatment Outcome

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  • (PMID = 17721191.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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