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Items 1 to 18 of about 18
1. Hasegawa Y, Tomita K, Hashimoto K, Shigeoka Y, Watanabe M, Yamasaki A, Shimizu E: Des-gamma-carboxy prothrombin (PIVKA-II)-producing mediastinal embryonal carcinoma with features of hepatoid differentiation. Anticancer Res; 2005 Nov-Dec;25(6C):4569-71
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  • [Title] Des-gamma-carboxy prothrombin (PIVKA-II)-producing mediastinal embryonal carcinoma with features of hepatoid differentiation.
  • The case of a 48-year-old man with primary nonseminomatous embryonal carcinoma at the posterior mediastinum is described.
  • The patient displayed extremely high plasma levels of Des-gamma-carboxy prothrombin (PIVKA-II) (4040 mAU/ml).
  • Ultrasonography and dynamic computed tomography ruled out hepatocellular carcinoma (HCC) or liver metastasis.
  • After preoperative systemic chemotherapy, total tumor resection was performed.
  • An immnohistochemical study using anti-PIVKA-II monoclonal antibody revealed the cytoplasmic expression of PIVK4-II in the carcinoma cells.
  • This case seems to be the first case reported in which PIVKA-II was produced by nonseminomatous mediastinal embryonal carcinoma without HCC or liver metastasis.
  • [MeSH-major] Biomarkers / blood. Carcinoma, Embryonal / blood. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Mediastinal Neoplasms / blood. Protein Precursors / blood
  • [MeSH-minor] Cell Differentiation / physiology. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged. Prothrombin

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  • (PMID = 16334143.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Protein Precursors; 53230-14-1 / acarboxyprothrombin; 9001-26-7 / Prothrombin
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2. Murakawa Y, Satake N, Kato S, Yosioka T, Kanamaru R: Alpha-FP normalization as a prognostic factor for mediastinal origin embryonal carcinoma: report of five cases. Intern Med; 2002 Oct;41(10):883-8
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  • [Title] Alpha-FP normalization as a prognostic factor for mediastinal origin embryonal carcinoma: report of five cases.
  • It is well known that a subgroup of germ cell tumors, embryonal carcinoma of extra-gonadal origin have a poor prognosis.
  • We have encountered five cases of mediastinal embryonal carcinoma treated with high-dose chemotherapy (HD-CT) supported by auto-PBSCT in four, and resection in three.
  • Our cases indicated that normalization of the alpha-FP tumor marker level during standard chemotherapy is a very important factor for cure, and the resection of the residual mass after chemotherapy is indicated due to the great risk of remnant malignant cells despite HD-CT.
  • [MeSH-major] Carcinoma, Embryonal / metabolism. Mediastinal Neoplasms / metabolism. alpha-Fetoproteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Humans. Male. Mediastinum / pathology. Mediastinum / radiography. Peripheral Blood Stem Cell Transplantation. Prognosis. Radiography, Thoracic. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 12413016.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / alpha-Fetoproteins
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3. Matsumoto S, Matsuda H, Uejima S, Kurita T: [Secondary leukemia following ultra high-dose chemotherapy with peripheral blood stem cell autotransplantation for refractory testicular cancer]. Nihon Hinyokika Gakkai Zasshi; 2000 Oct-Nov;91(10-11):687-91
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  • [Title] [Secondary leukemia following ultra high-dose chemotherapy with peripheral blood stem cell autotransplantation for refractory testicular cancer].
  • Secondary leukemia following chemotherapy or radiotherapy for mediastinal germ cell tumors in a well-described entity.
  • We report a case of secondary leukemia occurring in a 31-year-old man who received ultra high-dose chemotherapy with peripheral blood stem cell autotransplantation (PBSCT) for a refractory testicular cancer (pathology; Seminoma, Embryonal carcinoma, Yolk sac tumor, Choriocarcinoma) with IIIB2 under Japanese classification, poor-risk group under Indiana classification.
  • He received total 11 cycles of systemic chemotherapy (2 cycles of PVB regimen, 4 cycles of PEB regimen, 3 cycles of VIP regimen and 2 cycles of ultra high-dose chemotherapy with PBSCT for pulmonary and para-aortic lymph node metastasis following his initial orchiectomy.
  • Severe and persistent pancytopenia developed 25 months after his initial orchiectomy.
  • Therefore, he was diagnosed as secondary leukemia following high-dose chemotherapy.
  • He received total 6 cycles of systematic chemotherapy for the secondary leukemia in the internal department.
  • To our knowledge, this is the first reported case in the literature relevant to secondary leukemia following ultra high-dose chemotherapy with PBSCT in testicular tumor in Japan.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Carcinoma, Embryonal / drug therapy. Choriocarcinoma / drug therapy. Hematopoietic Stem Cell Transplantation. Leukemia / etiology. Neoplasms, Second Primary / etiology. Seminoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Bleomycin / adverse effects. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Etoposide / administration & dosage. Etoposide / adverse effects. Humans. Male. Transplantation, Autologous

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  • (PMID = 11109821.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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4. El Mesbahi O, Terrier-Lacombe MJ, Rebischung C, Theodore C, Vanel D, Fizazi K: Chemotherapy in patients with teratoma with malignant transformation. Eur Urol; 2007 May;51(5):1306-11; discussion 1311-2
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  • [Title] Chemotherapy in patients with teratoma with malignant transformation.
  • The only published series of patients with TMT treated with chemotherapy comprised 10 patients.
  • Other histological types included adenocarcinoma (n=3) and bronchoalveolar carcinoma (n=1).
  • RESULTS: Primary treatment consisted of surgery alone in 4 patients.
  • The remaining 10 patients received first-line cisplatin-based chemotherapy with resection of residual masses (n=5): 4 patients had a complete response and 5 had a partial response.
  • Overall, 9 patients developed a relapse with a median time of 84 mo (range: 6-168).
  • At relapse, 8 patients received a chemotherapy regimen directed to the non-GCT component.
  • CONCLUSION: To our knowledge, this is by far the largest reported European series of chemotherapy in TMT.
  • Although TMT has a poor prognosis compared to GCT, its management may be improved by adapted chemotherapy associated with surgical resection of residual masses.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / drug therapy. Teratoma / drug therapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adult. Humans. Male. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / pathology. Middle Aged. Retroperitoneal Neoplasms / drug therapy. Retroperitoneal Neoplasms / pathology. Sarcoma / drug therapy. Sarcoma / pathology. Testicular Neoplasms / drug therapy. Testicular Neoplasms / pathology

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  • (PMID = 17081678.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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5. Völkl TM, Langer T, Aigner T, Greess H, Beck JD, Rauch AM, Dörr HG: Klinefelter syndrome and mediastinal germ cell tumors. Am J Med Genet A; 2006 Mar 1;140(5):471-81
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  • [Title] Klinefelter syndrome and mediastinal germ cell tumors.
  • However, there is an increased incidence of mediastinal germ cell tumors (M-GCT) in KS, whereas the discussion of a generally higher tumor risk in this condition is still controversial.
  • Laboratory analyses (suppressed gonadotropins, elevated testosterone) and thoracic CT demonstrated a beta-human chorionic gonadotropin (beta-hCG) and alpha(1)-feto protein (alpha-FP) secreting mediastinal tumor.
  • Histological analysis showed a mixed germ cell tumor comprising choriocarcinoma (CH), embryonal carcinoma (EC), mature teratoma (MT), and yolk sac tumor (YS).
  • He was successfully treated by surgery and adjuvant chemotherapy.
  • There is still no convincing explanation for the association of M-GCTs and KS.
  • [MeSH-major] Klinefelter Syndrome / complications. Mediastinal Neoplasms / complications. Neoplasms, Germ Cell and Embryonal / complications. Puberty, Precocious / complications

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  • (PMID = 16470792.001).
  • [ISSN] 1552-4825
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Habuchi T, Kamoto T, Hara I, Kawai K, Nakao M, Nonomura N, Kobayashi T, Ogawa O, Kamidono S, Akaza H, Okuyama A, Kato T, Miki T: Factors that influence the results of salvage surgery in patients with chemorefractory germ cell carcinomas with elevated tumor markers. Cancer; 2003 Oct 15;98(8):1635-42
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  • BACKGROUND: A standard concept for the integration of surgery into the chemotherapy-based treatment of patients with advanced germ cell carcinoma has been that surgery should be avoided in patients with serum tumor markers (alpha-fetoprotein [AFP] and human chorionic gonadotropin [HCG]) that remain elevated.
  • The objective of this retrospective study was to clarify the outcome and clinical prognostic variables of salvage surgery in patients with disseminated (AJCC Stage II or III) testicular germ cell carcinoma or extragonadal germ cell carcinoma who had elevated serum markers.
  • METHODS: The authors reviewed the clinical records of 24 patients who underwent salvage surgery with elevated serum AFP and/or HCG levels after at least 3 courses of cisplatin-based, systemic chemotherapy between January, 1985 and December, 2000.
  • RESULTS: Ten of 24 patients (41.7%) were rendered free of disease and alive without disease after the surgery with or without adjuvant therapy at a median follow-up of 74 months (range, 24-207 months).
  • In addition, patients who had visceral lesions at resection had a significantly poorer prognosis compared with patients who had retroperitoneal and/or mediastinal lymph node lesions (P = 0.038; log-rank test).
  • CONCLUSIONS: Salvage surgery in patients with high serum tumors markers resulted in long-term disease free status in approximately 40% of patients in a small subset with advanced germ cell carcinoma.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Chorionic Gonadotropin / blood. Humans. Lymph Nodes / pathology. Male. Middle Aged. Prognosis. Retrospective Studies. Salvage Therapy. Survival Rate. alpha-Fetoproteins / analysis

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  • [Copyright] Copyright 2003 American Cancer Society.
  • (PMID = 14534879.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin; 0 / alpha-Fetoproteins
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7. Funahashi M, Tuchiya F, Makiyama K, Sugiura S, Miyoshi Y, Kishida T, Ogawa T, Uemura H, Yao M, Kubota Y: [Two cases of testicular tumors with high alpha-fetoprotein levels: a case report]. Hinyokika Kiyo; 2005 Feb;51(2):133-7
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  • Diagnosis was an authentic stage I seminoma.
  • In 2002, chemotherapy was performed for a metastatic seminoma revealed as a solitary mass in the mediastinum by radiographic studies, and histologically confirmed to be a metastatic seminoma.
  • Case 2: In 2002, a 30-year-old male underwent left high orchiectomy for a left testicular tumor, and histological examination revealed seminoma, immature and mature teratoma, embryonal carcinoma.
  • Diagnosis was authentic stage I.
  • After 2 courses of chemotherapy, the serum AFP remained at an abnormally high concentration.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Embryonal / diagnosis. Neoplasms, Multiple Primary / diagnosis. Seminoma / diagnosis. Teratoma / diagnosis. Testicular Neoplasms / diagnosis. alpha-Fetoproteins / analysis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Disease-Free Survival. Follow-Up Studies. Humans. Male. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / secondary. Orchiectomy

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  • (PMID = 15773370.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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8. Archie PH, Beasley MB, Ross HJ: Biphasic pulmonary blastoma with germ cell differentiation in a 36-year-old man. J Thorac Oncol; 2008 Oct;3(10):1185-7
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  • We describe the clinical and pathologic findings of a young man with a heterogeneous mediastinal tumor metastatic to both lungs, and containing a predominant pattern of classic biphasic pulmonary blastoma with elements of immature teratoma, seminoma, and embryonal carcinoma.
  • Surgery is the primary treatment, but prognosis is poor and chemotherapy and radiation have been used for unresectable disease.
  • [MeSH-major] Lung Neoplasms / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Multiple Primary / pathology. Pulmonary Blastoma / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow Transplantation. Cell Differentiation. Chorionic Gonadotropin, beta Subunit, Human / analysis. Combined Modality Therapy. Humans. Male. alpha-Fetoproteins / analysis

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  • (PMID = 18827617.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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9. Kobayashi N, Koizumi T, Eguchi T, Hyogotani A, Saito G, Hamanaka K, Shiina T, Kurai M, Kondo R, Yoshida K, Amano J: A mediastinal somatic-type germ cell tumor with hepatic metastasis successfully treated by multiple modalities. Anticancer Res; 2010 Dec;30(12):5117-20
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  • [Title] A mediastinal somatic-type germ cell tumor with hepatic metastasis successfully treated by multiple modalities.
  • Rhabdomyosarcoma in the mediastinum coexisting with metastatic non-seminomatous germ cell tumor, so-called somatic-type malignancy, is a rare carcinoma and has poor survival.
  • This study reports a case of diffuse and huge hepatic metastasis of non-seminomatous germ cell tumor associated with coexisting embryonal rhabdomyosarcoma in the mediastinum.
  • A 31-year-old man presented with abdominal pain and was found to have multiple abnormal hepatic masses on abdominal computed tomography (CT).
  • Concomitantly, an anterior mediastinal mass was found on chest CT.
  • Chemotherapy was initiated because the hepatic lesion was diagnosed as choriocarcinoma, based on histological findings and the elevation of chorionic gonadotropin β-subunit and α-fetoprotein.
  • After six cycles of bleomycin, etoposide and cisplatin chemotherapy the metastatic liver tumors showed complete response.
  • The remaining mediastinal tumor was completely and successfully resected.
  • The histological findings revealed mature teratoma with embryonal rhabdomyosarcoma.
  • The patient has remained well for over six years after the treatment without any signs of disease recurrence.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / drug therapy. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Mediastinal Neoplasms / drug therapy. Rhabdomyosarcoma, Embryonal / drug therapy. Teratoma / drug therapy

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  • (PMID = 21187499.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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10. Chen KN, Xu SF, Gu ZD, Zhang WM, Pan H, Su WZ, Li JY, Xu GW: Surgical treatment of complex malignant anterior mediastinal tumors invading the superior vena cava. World J Surg; 2006 Feb;30(2):162-70

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  • [Title] Surgical treatment of complex malignant anterior mediastinal tumors invading the superior vena cava.
  • Determining the appropriate surgery-based treatment for complicated anterior mediastinal malignancies (CAMM), especially those invading the superior vena cava (SVC) and its branches, remains a challenge for general thoracic surgeons.
  • In this report, we summarize our experience and lessons regarding this issue in order to discuss a reasonable strategy for diagnosis and treatment of CAMM.
  • Thymic carcinoma, teratoma, embryonal carcinoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, and mixed teratoma with thymoma were diagnosed in 1 patient each.
  • Four of the patients underwent perioperative chemotherapy.
  • CAMM can be safely and completely resected via a median sternotomy, even if it has invaded other mediastinal structures.
  • CAMM should be pathologically identified before initial treatment.
  • A good outcome for patients with CAMM is possible if a suitable strategy combining accurate diagnosis and appropriate treatment, especially surgical resection, is established.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / surgery. Neoplasm Invasiveness / pathology. Thoracotomy / methods. Vena Cava, Superior / pathology
  • [MeSH-minor] Adult. Aged. Anastomosis, Surgical. Angiography. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Humans. Lymphoma, Non-Hodgkin / mortality. Lymphoma, Non-Hodgkin / pathology. Lymphoma, Non-Hodgkin / therapy. Male. Middle Aged. Neoplasm Staging. Postoperative Complications / mortality. Preoperative Care. Prognosis. Retrospective Studies. Risk Assessment. Survival Analysis. Thymectomy / methods. Thymoma / drug therapy. Thymoma / mortality. Thymoma / pathology. Thymoma / surgery. Thymus Neoplasms / drug therapy. Thymus Neoplasms / mortality. Thymus Neoplasms / pathology. Thymus Neoplasms / surgery. Treatment Outcome

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  • (PMID = 16425072.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Omezzine N, Khouatra C, Larivé S, Freyer G, Isaac-Pinet S, Gérinière L, Droz JP, Souquet PJ: Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report. Ann Oncol; 2002 Feb;13(2):323-6
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  • [Title] Rhabdomyosarcoma arising in mediastinal teratoma in an adult man: a case report.
  • We report a case of rhabdomyosarcoma which occurred in a mediastinal teratoma in a 44-year-old man.
  • Diagnosis was fortuitous, performed by the histological and immunohistochemical study of a mediastinal tumour biopsy specimen that showed embryonal carcinoma and yolk sac tumour components associated with the rhabdomyosarcoma.
  • After cisplatin-based chemotherapy (bleomycin-etoposide-cisplatin), surgical resection of the residual mediastinal tumour was performed.
  • Histological and immunohistochemical study of this tumour confirmed the presence of mature teratoma and embryonal rhabdomyosarcoma.
  • Evolution was marked by a local extension of the mediastinal tumour, occurrence of multiple metastases and bone marrow involvement.
  • The patient died 8 months after diagnosis despite chemotherapy and radiotherapy.
  • A review of the literature reveals that the development of rhabdomyosarcoma in primary mediastinal teratomas is unusual in adults.
  • The diagnostic, therapeutic and prognostic implications of such an association are reviewed.

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  • (PMID = 11886012.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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12. Song SY, Ko YH, Ahn G: Mediastinal germ cell tumor associated with histiocytic sarcoma of spleen: case report of an unusual association. Int J Surg Pathol; 2005 Jul;13(3):299-303
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  • [Title] Mediastinal germ cell tumor associated with histiocytic sarcoma of spleen: case report of an unusual association.
  • We present an unusual association of mediastinal germ cell tumor containing seminoma and angiosarcoma components and splenic histiocytic sarcoma.
  • Histopathologically, an anterior mediastinal mass contained typical seminoma, immature teratoma, embryonal carcinoma, angiosarcoma, yolk sac tumor, and polyembryoma.
  • An abdominal ultrasonogram revealed a huge splenomegaly with multiple ill-defined low echogenic nodules, 1 month after the second cycle of chemotherapy.
  • [MeSH-major] Hemangiosarcoma / pathology. Histiocytic Sarcoma / pathology. Mediastinal Neoplasms / pathology. Seminoma / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Male. Neoplasms, Multiple Primary. Splenomegaly. Treatment Outcome

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  • (PMID = 16086090.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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13. Okur E, Halezeroglu S, Somay A, Atasalihi A: Unusual intrathoracic location of a primary germ cell tumour. Eur J Cardiothorac Surg; 2002 Oct;22(4):651-3
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  • The primary location of non-metastatic germ cell tumours of the chest is the anterior mediastinal compartment.
  • Here we report a case of intrapulmonary mixed type germ cell tumour, containing embryonal carcinoma, choriocarcinoma and yolk sac tumour elements.
  • Diagnosis of the lesion was achieved by open thoracotomy and bulk of the tumour was resected by right upper lobectomy.
  • [MeSH-major] Lung Neoplasms / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Carcinoma, Embryonal / diagnosis. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / surgery. Chemotherapy, Adjuvant. Choriocarcinoma / drug therapy. Choriocarcinoma / pathology. Choriocarcinoma / surgery. Cisplatin / administration & dosage. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / surgery. Etoposide / administration & dosage. Humans. Lung / radiography. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 12297196.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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14. Vuky J, Bains M, Bacik J, Higgins G, Bajorin DF, Mazumdar M, Bosl GJ, Motzer RJ: Role of postchemotherapy adjunctive surgery in the management of patients with nonseminoma arising from the mediastinum. J Clin Oncol; 2001 Feb 01;19(3):682-8
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  • [Title] Role of postchemotherapy adjunctive surgery in the management of patients with nonseminoma arising from the mediastinum.
  • PURPOSE: To evaluate the role of postchemotherapy surgery in patients with nonseminomatous germ cell tumors arising from the anterior mediastinum.
  • PATIENTS AND METHODS: Thirty-two patients with nonseminoma arising from a mediastinal primary site were treated on a clinical trial at our center, and they underwent postchemotherapy surgery.
  • Viable tumor included embryonal carcinoma, choriocarcinoma, yolk sac carcinoma, seminoma, and teratoma with malignant transformation to nongerm cell histology (eg, sarcoma).
  • CONCLUSION: Surgical resection of residual mass after chemotherapy plays an integral role in the management of patients with primary mediastinal nonseminoma.
  • Teratoma and viable tumor were found in the majority of resected residua after chemotherapy.
  • Because patients who undergo conventional salvage chemotherapy programs rarely achieve long-term disease-free status, selected patients with elevated markers after chemotherapy are considered candidates for surgical resection.
  • [MeSH-major] Germinoma / surgery. Mediastinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Chorionic Gonadotropin, beta Subunit, Human / blood. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Neoadjuvant Therapy. Prognosis. Prospective Studies. Randomized Controlled Trials as Topic. Survival Rate. alpha-Fetoproteins / metabolism

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  • (PMID = 11157018.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-09207-23
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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15. Cheng MF, Peng YJ, Huang GS, Lee CH, Chiang PC, Lee HS: Unusual scapular metastasis as initial manifestation of advanced nonseminomatous germ cell tumor of the mediastinum. Heart Lung; 2007 Jan-Feb;36(1):79-84
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  • [Title] Unusual scapular metastasis as initial manifestation of advanced nonseminomatous germ cell tumor of the mediastinum.
  • Primary malignant germ cell tumors of the mediastinum are relatively rare, occurring predominantly in young male adults, and have a poor prognosis.
  • Excisional biopsy of the scapula revealed a metastatic carcinoma, suggestive of nonseminomatous germ cell tumor origin.
  • Chest computed tomography and magnetic resonance imaging showed a primary tumor mass in the anterior mediastinum.
  • Chemotherapy with cisplatin, bleomycin, and etoposide was administered for six courses.
  • The mediastinal tumor mass was markedly reduced in size and remission without evidence of tracer uptake by [(18)F]fluorodeoxyglucose positron emission tomography examination.
  • Six months after chemotherapy, the patient received advanced surgical intervention to remove the mediastinal tumor, the pathologic features of which were similar to the previous scapular lesion.
  • [MeSH-major] Bone Neoplasms / secondary. Mediastinal Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / secondary. Scapula
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 17234481.001).
  • [ISSN] 0147-9563
  • [Journal-full-title] Heart & lung : the journal of critical care
  • [ISO-abbreviation] Heart Lung
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Landolsi A, Tarmiz H, Ben Fatma L, Kallel L, Gharbi O, Kraïem C, Korbi S, Ben Ahmed S: [Diagnosis and treatment of primary germ cell tumors of the mediastinum. Report of six cases]. Tunis Med; 2003 Jun;81(6):419-24

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  • [Title] [Diagnosis and treatment of primary germ cell tumors of the mediastinum. Report of six cases].
  • [Transliterated title] Diagnostic et traitement des tumeurs germinales malignes primitives du mediastin. A propos de six cas.
  • Primary germ cell tumours of the mediastinum are rare.
  • The tumor site was the posterior mediastinum in two patients and anterior in the remaining cases.
  • At histologic exam we found two cases of seminoma, one embryonal carcinoma, one case of yolk sac tumor and two cases of composite tumor.
  • All patients had non metastatic but locally advanced disease at diagnosis.
  • Three patients were treated with cisplatin based chemotherapy followed by radiotherapy or surgical resection of residual masses.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / therapy. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / therapy

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  • (PMID = 14534949.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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17. Mardiak J, Sálek T, Sycová-Milá Z, Obertová J, Recková M, Mego M, Hlavatá Z, Brozmanová K, Risnyovzská Z, Svetlovská D, Koza I: Paclitaxel, bleomycin, etoposide, and cisplatin (T-BEP) as initial treatment in patients with poor-prognosis germ cell tumors (GCT): a phase II study. Neoplasma; 2007;54(3):240-5
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  • [Title] Paclitaxel, bleomycin, etoposide, and cisplatin (T-BEP) as initial treatment in patients with poor-prognosis germ cell tumors (GCT): a phase II study.
  • First line treatment of patients pts with poor-prognosis GCT, using BEP, is unsatisfactory.
  • Twenty-four pts received T-BEP as initial therapy.
  • Three pts (12.5%) had primary mediastinal GCT.
  • Four cycles of T-BEP were given 21 days apart.
  • Median survival was not achieved and median time-to-progression is 9.5 months.
  • There were two treatment-related deaths due to sepsis.
  • Patients treated with 1st line T-BEP didn't achieve higher response rate or time to progression.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasms, Germ Cell and Embryonal / drug therapy
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / secondary. Choriocarcinoma / drug therapy. Choriocarcinoma / secondary. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Prognosis. Prospective Studies. Teratocarcinoma / drug therapy. Teratocarcinoma / secondary. Testicular Neoplasms / drug therapy. Testicular Neoplasms / secondary

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  • (PMID = 17447857.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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18. Ahmed SM, Cramer H, Ulbright TM, Vance GH, Hanna N: Large cell carcinoma of the lung mimicking a germ cell tumor: the potential value of chromosome analysis. Lung Cancer; 2005 Aug;49(2):271-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell carcinoma of the lung mimicking a germ cell tumor: the potential value of chromosome analysis.
  • [MeSH-major] Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / genetics. Chromosomes, Human / genetics. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / genetics
  • [MeSH-minor] Adult. Choriocarcinoma / diagnosis. Choriocarcinoma / drug therapy. Choriocarcinoma / genetics. Humans. In Situ Hybridization, Fluorescence. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lung Neoplasms / genetics. Male. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / genetics

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  • (PMID = 16022922.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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