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1. Gomes Mda M, Lucca I, Bezerra SA, Llerena J Jr, Moreira DM: Epilepsy and ring chromosome 20: case report. Arq Neuropsiquiatr; 2002 Sep;60(3-A):631-5
MedlinePlus Health Information. consumer health - Epilepsy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present the clinical, electroencephalographic, neuroimaging (brain magnetic resonance image - MRI and spectroscopy by MRI) and cytogenetic findings of a young male patient with a rare cytogenetic anomaly characterised by a de novo 46,XY,r(20)(p13q13.3) karyotype.
  • There are brain anomalies characterised by corpus callosum, uvula, nodule and cerebellum pyramid hypoplasias, besides arachnoid cysts in the occipital region.
  • He had seizures refractory to pharmacotherapy and long period of confusional status with or without a motor component.
  • The authors recognised that the EEG pattern was not fixed but changed over time, specially for bursts of slow waves with great amplitude accompanied or not by sharp components, and bursts of theta waves sharply contoured.

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  • (PMID = 12244405.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Brazil
  • [Number-of-references] 15
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2. Rocha I, Gonçalves V, Bettencourt MJ, Silva-Carvalho L: Effect of stimulation of sublobule IX-b of the cerebellar vermis on cardiac function. Physiol Res; 2008;57(5):701-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cardiac performance during the isovolumic phases of systole and relaxation can be evaluated by dP/dtmax, Vpm, dP/dt/DP40 and tau, respectively.
  • A posterior craniotomy was made to reveal and stimulate the cerebellar uvula (4 s train; 50 Hz; 1 ms; 20 microA).

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  • (PMID = 17949257.001).
  • [ISSN] 0862-8408
  • [Journal-full-title] Physiological research
  • [ISO-abbreviation] Physiol Res
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
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3. Daghistani KJ: Conditions of the uvula: a 14 years experience. Auris Nasus Larynx; 2000 Jul;27(3):261-4
MedlinePlus Health Information. consumer health - Wounds and Injuries.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conditions of the uvula: a 14 years experience.
  • OBJECTIVE: A retrospective study to find out the aetiology, symptomatology and management of elongated and enlarged uvulae.
  • CONCLUSION: Enlarged or elongated uvulae are rare but solitary involvement of uvula because of variety of causes occur.
  • [MeSH-major] Mouth Diseases / therapy. Uvula / injuries. Wounds and Injuries / therapy
  • [MeSH-minor] Carcinoma, Squamous Cell / surgery. Humans. Mouth Neoplasms / surgery. Postoperative Complications / drug therapy. Postoperative Complications / surgery. Retrospective Studies

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  • (PMID = 10808116.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
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4. Wu MD, Kimura M, Kusumi T, Taguchi A, Nakayama M, Inafuku S: ["Restricted ablation" of elongated uvula mucosa by the injection of the ethanol/steroid mixture: a new treatment for snoring and OSAS]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Jan;108(1):15-9
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  • [Title] ["Restricted ablation" of elongated uvula mucosa by the injection of the ethanol/steroid mixture: a new treatment for snoring and OSAS].
  • We developed a "Submucosal Ethanol/Steroid (E/S) Injection Method (SEIM)" using an injection prepared by dissolving steroid with powerful antiinflammatory effect, which has the excellent effect of contractile reduction in oral tissues.
  • In this clinical trial, the ablation effect of SEIM on the abnormally elongated uvula and the soft palate was examined in each one clinical case of obstructive sleep apnea syndrome (OSAS) and simple snoring.
  • In the OSAS, we found that the uvula was reduced from 15 to 10mm, the visual analog scale (VAS) of snoring was reduced from 10 to 4 points, and the respiration disturbance index of the apnea-hypopnea index (AHI) improved from 35.3 to 26.1 after treatment.
  • In simple snoring, the uvula was reduced from 11 to 8.5mm and VAS was relieved from 7 to 2 points after treatment.
  • Our approach will produce a great clinical significance for not only OSAS or simple snoring but also treatment of the allergic rhinitis, etc, because the contractile tissue reduction can be attained safely in these diseases without open surgical wounds and unnecessary deformation or destruction of the mucosal structure.
  • [MeSH-major] Dexamethasone / administration & dosage. Dexamethasone / analogs & derivatives. Ethanol / administration & dosage. Sleep Apnea, Obstructive / drug therapy. Snoring / drug therapy
  • [MeSH-minor] Adult. Drug Combinations. Humans. Injections. Male. Middle Aged. Mouth Mucosa. Treatment Outcome. Uvula

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  • Hazardous Substances Data Bank. DEXAMETHASONE .
  • Hazardous Substances Data Bank. ETHANOL .
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  • (PMID = 15712492.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] Case Reports; Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 312-93-6 / dexamethasone 21-phosphate; 3K9958V90M / Ethanol; 7S5I7G3JQL / Dexamethasone
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5. Godlevskii LS, Stepanenko KI, Lobasyuk BA, Sarakhan EV, Bobkova LM: The effects of electrical stimulation of the paleocerebellar cortex on penicillin-induced convulsive activity in rats. Neurosci Behav Physiol; 2004 Oct;34(8):797-802
MedlinePlus Health Information. consumer health - Seizures.

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  • Studies in Wistar rats in conditions of free behavior showed that low-frequency stimulation of the paleocerebellar cortex (nodulus, uvula) (10-12 Hz, 0.5 msec) was accompanied by activation of spike discharges induced by systematic application of benzylpenicillin sodium (3,000,000 IU/kg).
  • [MeSH-major] Cerebellar Cortex / radiation effects. Electric Stimulation. Seizures / therapy
  • [MeSH-minor] Action Potentials / drug effects. Action Potentials / radiation effects. Animals. Disease Models, Animal. Male. Penicillins. Rats. Rats, Wistar. Time Factors

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  • [Cites] Patol Fiziol Eksp Ter. 1989 May-Jun;(3):24-8 [2508043.001]
  • [Cites] Brain Res Bull. 1994;35(4):285-7 [7850475.001]
  • (PMID = 15587808.001).
  • [ISSN] 0097-0549
  • [Journal-full-title] Neuroscience and behavioral physiology
  • [ISO-abbreviation] Neurosci. Behav. Physiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Penicillins
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6. Boyce SH, Quigley MA: Uvulitis and partial upper airway obstruction following cannabis inhalation. Emerg Med (Fremantle); 2002 Mar;14(1):106-8
MedlinePlus Health Information. consumer health - Choking.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present a case in which a 17-year-old male regular cannabis user developed a large swollen uvula (uvulitis) and partial upper airway obstruction after smoking cannabis.
  • [MeSH-major] Airway Obstruction / chemically induced. Cannabis / poisoning. Laryngeal Edema / chemically induced. Uvula / physiopathology
  • [MeSH-minor] Administration, Inhalation. Adolescent. Drug Therapy, Combination. Emergency Service, Hospital. Humans. Male. Prognosis. Risk Assessment

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  • (PMID = 11993827.001).
  • [ISSN] 1035-6851
  • [Journal-full-title] Emergency medicine (Fremantle, W.A.)
  • [ISO-abbreviation] Emerg Med (Fremantle)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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7. Kolokotronis A, Avramidou E, Zaraboukas T, Mandraveli K, Alexiou S, Antoniades D: Oral tuberculosis associated with a treatment with anti-rheumatic drugs. J Oral Pathol Med; 2006 Feb;35(2):123-5
Hazardous Substances Data Bank. METHOTREXATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral tuberculosis associated with a treatment with anti-rheumatic drugs.
  • BACKGROUND: The use of immunosuppressive medication is a dominant risk factor for infection in patients with rheumatoid arthritis (RA).
  • Methotrexate (MTX) is one of the traditional disease-modifying antirheumatic drugs.
  • Adalimumab [a human anti-tumor necrosis factor-alpha (anti-TNF-alpha) monoclonal antibody] represent an important advance in the treatment of RA and has been recently come in use.
  • Infections occur at a high rate among those who use one or the combination of the two medications.
  • METHOD: We examined a female patient that was referred to our department for evaluation and treatment of a granular lesion on the soft palate and uvula, complaining of mild dysphagia.
  • CONCLUSIONS: The therapeutic use of MTX or/and adalimumab for the treatment of RA or few others diseases, can cause oral tuberculosis.
  • [MeSH-major] Antirheumatic Agents / therapeutic use. Arthritis, Rheumatoid / drug therapy. Immunosuppressive Agents / therapeutic use. Tuberculosis, Oral / diagnosis
  • [MeSH-minor] Adalimumab. Adult. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Humanized. Female. Humans. Methotrexate / therapeutic use. Mycobacterium tuberculosis / isolation & purification. Opportunistic Infections / diagnosis. Tuberculoma / diagnosis. Tumor Necrosis Factor-alpha / immunology

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  • (PMID = 16430744.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antirheumatic Agents; 0 / Immunosuppressive Agents; 0 / Tumor Necrosis Factor-alpha; FYS6T7F842 / Adalimumab; YL5FZ2Y5U1 / Methotrexate
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8. Hultcrantz E, Harder L, Harder H, Zetterlund EL, Roberg K: To treat snoring with nasal steroids - effects on more than one level? Acta Otolaryngol; 2010;130(1):124-31
MedlinePlus Health Information. consumer health - Snoring.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSION: An inflammatory swelling in the uvula and nose due to vibration might be a contributing factor in snoring.
  • The presence of corticosteroid receptors in the uvula indicates the possibility for treatment with local steroids.
  • SUBJECTS AND METHODS: In the first part of the study, uvular and nasal biopsies from six patients with social snoring were examined using immunohistochemistry to evaluate whether corticosteroid receptors were present.
  • Thereafter the procedure was repeated.
  • RESULTS: Corticosteroid receptors were present in the mucous membranes and around the blood vessels in all uvulas examined.
  • [MeSH-major] Anti-Inflammatory Agents / administration & dosage. Pregnadienediols / administration & dosage. Snoring / drug therapy
  • [MeSH-minor] Administration, Intranasal. Adolescent. Adult. Aged. Biopsy. Female. Humans. Male. Middle Aged. Mometasone Furoate. Nasal Mucosa / drug effects. Nasal Mucosa / pathology. Receptors, Steroid / analysis. Receptors, Steroid / drug effects. Uvula / drug effects. Uvula / pathology. Young Adult

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  • (PMID = 19449224.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Pregnadienediols; 0 / Receptors, Steroid; 04201GDN4R / Mometasone Furoate
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9. Nowaczewska K, Wójtowicz P, Kukwa A, Ratajczak J, Tulibacki M: [Respiratory papillomatosis--new methods of treatment]. Otolaryngol Pol; 2010 Jan-Feb;64(1):31-6
Hazardous Substances Data Bank. CIDOFOVIR .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Respiratory papillomatosis--new methods of treatment].
  • The most common location in head and neck is larynx, palatine tonsils and arches of palate, uvula and mucosa oral and nasal cavity.
  • The aim of this study was to estimate new methods of treatment respiratory papillomatosis based on intralesional injection of cidofovir into sites where papillomas had just been excised.
  • The treatment was based on surgical excision of papilloma and after it intralesional injection of cidofovir in after 4-5 weeks.
  • 41 patients had 4 times intralesional injection of cidofovir.
  • We observed that this treatment caused long lasting remission of papilloma recurrence.
  • [MeSH-major] Antiviral Agents / administration & dosage. Cytosine / analogs & derivatives. Laryngeal Neoplasms / drug therapy. Organophosphonates / administration & dosage. Papilloma / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Drug Administration Schedule. Female. Humans. Injections, Intralesional. Male. Middle Aged. Neoplasm Staging. Poland. Remission Induction. Treatment Outcome. Young Adult

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  • (PMID = 20476590.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Organophosphonates; 8J337D1HZY / Cytosine; JIL713Q00N / cidofovir
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10. Kayrak M, Ulgen MS, Yazici M, Kiliç D, Gok H: Uvula haematoma: a rare complication after thrombolysis and intensive anti-platelet treatment. Ann Card Anaesth; 2007 Jul;10(2):140-1
Hazardous Substances Data Bank. CLOPIDOGREL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uvula haematoma: a rare complication after thrombolysis and intensive anti-platelet treatment.
  • [MeSH-major] Anticoagulants / adverse effects. Hematoma / chemically induced. Oral Hemorrhage / chemically induced. Uvula
  • [MeSH-minor] Chest Pain / drug therapy. Drug Therapy, Combination. Enoxaparin / adverse effects. Fibrinolytic Agents / adverse effects. Humans. Male. Middle Aged. Streptokinase / adverse effects. Ticlopidine / adverse effects. Ticlopidine / analogs & derivatives

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  • (PMID = 17644888.001).
  • [ISSN] 0971-9784
  • [Journal-full-title] Annals of cardiac anaesthesia
  • [ISO-abbreviation] Ann Card Anaesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Enoxaparin; 0 / Fibrinolytic Agents; A74586SNO7 / clopidogrel; EC 3.4.- / Streptokinase; OM90ZUW7M1 / Ticlopidine
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