[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 25 of about 25
1. Koshida K, Kato H, Mizokami A, Morishita H, Seto C, Komatsu K, Kou E, Uchibayashi T, Shiobara S, Namiki M: High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer. Int J Urol; 2002 Mar;9(3):146-53
Hazardous Substances Data Bank. CYCLOPHOSPHAMIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer.
  • BACKGROUND: The aim of this study was to investigate the efficacy and safety of high-dose chemotherapy (HDCT) for the treatment of patients with advanced testicular cancer.
  • The treatment was used for two refractory cases, a second relapse, and for consolidation after the first relapse in one case each.
  • It was also used for nine cases as part of the first-line treatment following primary conventional-dose chemotherapy, and for one case as the first salvage for a late recurrent tumor of teratoma with malignant transformation.
  • RESULTS: The first two patients who received intensive pretreatment with cisplatin-based chemotherapy did not respond to HDCT.
  • The two patients who were treated with HDCT as the first or second salvage therapy achieved successful outcomes.
  • Finally, a case of teratoma with malignant transformation did not respond well to two cycles of HDCT.
  • CONCLUSIONS: The results demonstrated the limited efficacy of HDCT even in cases with a good to intermediate risk rating according to classification by the International Germ Cell Cancer Collaborative Group.
  • Because treatment for relapse after HDCT is extremely difficult, new HDCT regimens consisting of drugs that are not used in induction chemotherapy need to be established.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hematopoietic Stem Cell Transplantation. Testicular Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Bleomycin / administration & dosage. Carboplatin / administration & dosage. Cisplatin / administration & dosage. Cyclophosphamide / administration & dosage. Dose-Response Relationship, Drug. Doxorubicin / administration & dosage. Doxorubicin / analogs & derivatives. Etoposide / administration & dosage. Humans. Male. Middle Aged. Teratoma / drug therapy. Teratoma / therapy

  • Genetic Alliance. consumer health - Testicular cancer.
  • Genetic Alliance. consumer health - Transplantation.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • Hazardous Substances Data Bank. BLEOMYCIN .
  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • Hazardous Substances Data Bank. ETOPOSIDE .
  • Hazardous Substances Data Bank. CARBOPLATIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12010324.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; D58G680W0G / pirarubicin; Q20Q21Q62J / Cisplatin; BEP protocol; CEC protocol
  •  go-up   go-down


2. Kasai T, Moriyama K, Tsuji M, Uema K, Sakurai N, Fujii Y: Adenocarcinoma arising from a mature cystic teratoma of the testis. Int J Urol; 2003 Sep;10(9):505-9
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma arising from a mature cystic teratoma of the testis.
  • Histopathological examination revealed a well-differentiated, mucinous adenocarcinoma originating from the gastrointestinal epithelium in a mature cystic teratoma (dermoid cyst) of the testis and metastatic mucinous adenocarcinoma of the skin.
  • We made a diagnosis of teratoma with malignant transformation (TMT) of the testis.
  • Combination chemotherapy with low-dose cisplatin/5'-deoxy-5-fluorouridine (CDDP/5'-DFUR) was initiated, but the patient died 8 months after orchiectomy.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / secondary. Dermoid Cyst / diagnosis. Skin Neoplasms / secondary. Teratoma / diagnosis. Testicular Neoplasms / diagnosis

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12941133.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  •  go-up   go-down


3. Hurwitz JL, Fenton A, McCluggage WG, McKenna S: Squamous cell carcinoma arising in a dermoid cyst of the ovary: a case series. BJOG; 2007 Oct;114(10):1283-7
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell carcinoma arising in a dermoid cyst of the ovary: a case series.
  • OBJECTIVE: Malignant transformation in a dermoid cyst of the ovary is a rare complication, occurring in only 1-2% of cases, with squamous cell carcinoma being the most common type.
  • Preoperative diagnosis is difficult because of the lack of specific symptoms and signs to suggest malignancy.
  • Because of the small numbers of women involved, our knowledge of this rare tumour type is limited.
  • DESIGN: We identified 14 women with this diagnosis between 1989 and 2006.
  • This is a descriptive study, looking at the patient characteristics, mode of presentation and the role of tumour markers and radiological imaging in diagnosis.
  • We also examined the stage and pathological features of the tumour at presentation and the subsequent course of the disease.
  • We have also described our experiences using surgery, chemotherapy and radiotherapy in the management of these women.
  • The behaviour of these tumours is unpredictable, and the role of chemotherapy and radiotherapy remains unclear.
  • We suggest that repeated surgical resection of disease at the time of relapse could give a very durable response in selected women.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Dermoid Cyst / pathology. Ovarian Neoplasms / pathology

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17877681.001).
  • [ISSN] 1471-0528
  • [Journal-full-title] BJOG : an international journal of obstetrics and gynaecology
  • [ISO-abbreviation] BJOG
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


Advertisement
4. Spiess PE, Pisters LL, Liu P, Pettaway CA, Kamat AM, Gomez JA, Tannir NM: Malignant transformation of testicular teratoma: a chemoresistant phenotype. Urol Oncol; 2008 Nov-Dec;26(6):595-9
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of testicular teratoma: a chemoresistant phenotype.
  • PURPOSE: To review our experience in the management of malignant transformation of teratoma (MTT).
  • RESULTS: Two patients presented with clinical stage I disease in which malignant transformation occurred within the primary testis tumor (rhabdomyosarcoma in 1 and adenocarcinoma in 1).
  • No viable tumor was identified in the specimen, and both patients were alive without disease at 16 months follow-up.
  • Of the remaining 7 patients, the clinical stages were IIA (N = 1), IIB (N = 3), and III (N = 3), and all were treated with chemotherapy followed by RPLND.
  • Following preoperative chemotherapy, a significant radiologic response (defined as more than a 25% reduction in maximum tumor circumferential diameter) was demonstrated in 1 patient, and normalization of serum tumor markers was demonstrated in 6.
  • CONCLUSIONS: In our experience, MTT is significantly resistant to current chemotherapeutic regimens, as demonstrated by its poor radiologic response to treatment.
  • Alternative therapeutic strategies targeted to MTT are thus needed.
  • [MeSH-major] Teratoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Drug Resistance, Neoplasm. Humans. Lymph Node Excision. Male. Neoplasm Staging. Retroperitoneal Space

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Oncol. 2005 Apr 20;23(12):2781-8 [15837993.001]
  • [Cites] Nihon Hinyokika Gakkai Zasshi. 1998 Jun;89(6):622-6 [9666691.001]
  • [Cites] Semin Urol Oncol. 1998 May;16(2):65-71 [9649229.001]
  • [Cites] J Urol. 1998 Mar;159(3):859-63 [9474169.001]
  • [Cites] Scand J Urol Nephrol. 2003;37(2):177-8 [12745729.001]
  • [Cites] Cancer. 1985 Aug 15;56(4):860-3 [2990657.001]
  • [Cites] J Clin Oncol. 2003 Dec 1;21(23):4285-91 [14645417.001]
  • [Cites] J Urol. 1998 Jan;159(1):133-8 [9400455.001]
  • [CommentIn] Urol Oncol. 2009 Mar-Apr;27(2):218; author reply 218-9 [19285238.001]
  • (PMID = 18367105.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS610854; NLM/ PMC4121060
  •  go-up   go-down


5. Miyake M, Fujimoto K, Matsushita C, Chihara Y, Tanaka M, Hirayama A, Hirao Y, Uemura H: [Tumor thrombus arising from the superior vena cava and extending into the right atrium in a patient with advanced testicular germ cell tumor]. Hinyokika Kiyo; 2009 Jun;55(6):371-5
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumor thrombus arising from the superior vena cava and extending into the right atrium in a patient with advanced testicular germ cell tumor].
  • A 24-year-old man was referred to our hospital with a painless mass on the left side of his neck.
  • Ultrasonography detected right testicular tumor and computerized tomography scanning revealed a left supraclavicular lymph node mass and bulky retroperitoneal lymph node mass.
  • He initially underwent right high orchiectomy, combination chemotherapy and retroperitoneal lymph node dissection for advanced testicular non-seminomatous germ cell tumor.
  • After complete remission of the lung metastasis with chemotherapy, the serum alpha-fetoprotein began to increase because of superior vena caval thrombus extending into the right atrium.
  • Emergency surgical excision was performed successfully using extracorporeal circulation to prevent pulmonary embolism and the resected specimen pathologically revealed adenocarcinoma interpreted as teratoma malignant transformation.
  • Adjuvant chemotherapy consisting of paclitaxel, ifosfamide and nedaplatin were administered for subsequent slight elevation of serum F-human chorionic gonadotropin beta, resulting in successful normalization again.
  • We report herein an extremely uncommon case of advanced testicular germ cell tumor with development of superior vena caval thrombus extending into the right atrium.
  • [MeSH-minor] Chorionic Gonadotropin, beta Subunit, Human / blood. Humans. Lung Neoplasms / secondary. Male. Young Adult

  • MedlinePlus Health Information. consumer health - Blood Clots.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19588874.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
  • [Number-of-references] 22
  •  go-up   go-down


6. Amjad AI, Pal I: De novo primary squamous cell carcinoma of the ovary: a case of a rare malignancy with an aggressive clinical course. J Pak Med Assoc; 2008 May;58(5):272-4
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ovarian squamous cell carcinoma is a rare malignancy and the occurrence is attributable to malignant transformation of an existing ovarian dermoid cyst.
  • The de novo occurrence of squamous cell carcinoma of the ovary, in the absence of an antecedent ovarian dermoid, is extremely rare.
  • Abdominal CT was suggestive of a malignant neoplastic process.
  • Laparotomy confirmed a malignant tumour with involvement of the right adnexa and extension into the omentum and bowel.
  • Histopathology demonstrated squamous cell carcinoma arising from the right ovary with no co-existing ovarian dermoid.
  • The postoperative period was significant for disease progression despite adjuvant chemotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Ovarian Neoplasms / diagnosis. Ovariectomy / methods
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Colectomy / methods. Diagnosis, Differential. Disease Progression. Elective Surgical Procedures / methods. Female. Follow-Up Studies. Humans. Ileostomy / methods. Laparotomy. Neoplasm Staging. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18655408.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  •  go-up   go-down


7. Donadio AC, Motzer RJ, Bajorin DF, Kantoff PW, Sheinfeld J, Houldsworth J, Chaganti RS, Bosl GJ: Chemotherapy for teratoma with malignant transformation. J Clin Oncol; 2003 Dec 1;21(23):4285-91
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy for teratoma with malignant transformation.
  • PURPOSE: Teratoma with malignant transformation (MT) is a well-described entity that refers to the MT of a somatic teratomatous component in a germ cell tumor (GCT) to a histology that is identical to a somatic malignancy (eg, rhabdomyosarcoma [RMS]).
  • Surgical resection has been the mainstay of therapy for localized transformed disease because these tumors are thought to be resistant to standard treatment.
  • We report that chemotherapy has a role in selected patients with MT, determined by cell type.
  • PATIENTS AND METHODS: Chemotherapy was administered to 12 patients with MT of GCT limited to a single cell type (two patients with primitive neuroectodermal tumors, five with undifferentiated RMS, one with anaplastic small-cell tumor, two with adenocarcinoma, and two with leukemia); 10 patients had measurable disease.
  • Each patient received chemotherapy regimens based on the specific malignant cell observed in the transformed histology.
  • Three patients did not respond to treatment, and all of those patients died as a result of their disease.
  • CONCLUSION: Chemotherapy for MT limited to a single cell type may result in major responses and long-term survival in selected patients.
  • Local therapy after chemotherapy is an important component of treatment to achieve maximum response.
  • [MeSH-major] Cell Transformation, Neoplastic / drug effects. Mediastinal Neoplasms / drug therapy. Teratoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adult. Carcinoma / drug therapy. Carcinoma / pathology. Carcinoma, Small Cell / drug therapy. Carcinoma, Small Cell / pathology. Chemotherapy, Adjuvant. Cytogenetics. Humans. Leukemia, Mast-Cell / drug therapy. Leukemia, Mast-Cell / pathology. Male. Middle Aged. Neoplasm Staging. Neuroectodermal Tumors, Primitive / drug therapy. Neuroectodermal Tumors, Primitive / pathology. Rhabdomyosarcoma / drug therapy. Rhabdomyosarcoma / pathology. Treatment Outcome

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 14645417.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


8. El Mesbahi O, Terrier-Lacombe MJ, Rebischung C, Theodore C, Vanel D, Fizazi K: Chemotherapy in patients with teratoma with malignant transformation. Eur Urol; 2007 May;51(5):1306-11; discussion 1311-2
Genetic Alliance. consumer health - Teratoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy in patients with teratoma with malignant transformation.
  • OBJECTIVE: Germ-cell tumours (GCTs) with a non-GCT malignant component are a unique and rare phenomenon called teratoma with malignant transformation (TMT).
  • The only published series of patients with TMT treated with chemotherapy comprised 10 patients.
  • Other histological types included adenocarcinoma (n=3) and bronchoalveolar carcinoma (n=1).
  • Immunohistochemistry was performed to help in identifying the malignant non-GCT component.
  • RESULTS: Primary treatment consisted of surgery alone in 4 patients.
  • The remaining 10 patients received first-line cisplatin-based chemotherapy with resection of residual masses (n=5): 4 patients had a complete response and 5 had a partial response.
  • Overall, 9 patients developed a relapse with a median time of 84 mo (range: 6-168).
  • At relapse, 8 patients received a chemotherapy regimen directed to the non-GCT component.
  • With a median follow-up of 59 mo (range: 3-180), 4 of 14 patients are alive, including 3 who are disease-free.
  • CONCLUSION: To our knowledge, this is by far the largest reported European series of chemotherapy in TMT.
  • Although TMT has a poor prognosis compared to GCT, its management may be improved by adapted chemotherapy associated with surgical resection of residual masses.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / drug therapy. Teratoma / drug therapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adult. Humans. Male. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / pathology. Middle Aged. Retroperitoneal Neoplasms / drug therapy. Retroperitoneal Neoplasms / pathology. Sarcoma / drug therapy. Sarcoma / pathology. Testicular Neoplasms / drug therapy. Testicular Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17081678.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


9. Athanasiou A, Vanel D, El Mesbahi O, Theodore C, Fizazi K: Non-germ cell tumours arising in germ cell tumours (teratoma with malignant transformation) in men: CT and MR findings. Eur J Radiol; 2009 Feb;69(2):230-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-germ cell tumours arising in germ cell tumours (teratoma with malignant transformation) in men: CT and MR findings.
  • PURPOSE: To describe the imaging findings of germ cell tumours (GCT) containing non-germ cell malignant components (also designated teratoma with malignant transformation or TMT).
  • All patients had computed tomography (CT) and/or magnetic resonance (MR) studies before and after initial surgery and chemotherapy, as well as during follow-up.
  • Imaging findings were correlated with the response to treatment and with overall survival.
  • Other histological types of malignant transformation included adenocarcinoma (n=3) and bronchoalveolar carcinoma (n=1).
  • Overall, 9 patients relapsed at a median time of 84 months (range 60-168).
  • RESULTS: Non-GCT malignant transformation was identified in the retroperitoneum (5), testis (3), mediastinum (3), peritoneum (2) and lungs (1).
  • The CT and MR imaging findings before treatment and after relapse were evaluated with emphasis on imaging features that could possibly imply the presence of malignant transformation (heterogeneously enhancing soft-tissue masses, ossified masses with calcified lymph nodes, diffuse epiploic thickening associated with ascites and peritoneal nodules, pulmonary alveolar infiltration with septal thickening).
  • Imaging can be useful as CT and MR findings may suggest this entity and lead to an early biopsy and appropriate treatment.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Magnetic Resonance Imaging. Teratoma / diagnosis. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - CT Scans.
  • MedlinePlus Health Information. consumer health - MRI Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19056194.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  •  go-up   go-down


10. Yamagami W, Banno K, Kawaguchi M, Yanokura M, Kuwabara Y, Hirao N, Susumu N, Tsukazaki K, Aoki D: Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma: a case report. Chemotherapy; 2007;53(2):137-41
Hazardous Substances Data Bank. CARBOPLATIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma: a case report.
  • BACKGROUND: The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells.
  • We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ovarian mature cystic teratoma.
  • CASE REPORT: The patient was a 70-year-old female with an ovarian tumor, pleural effusion, carcinomatous ascites and a chest wall tumor.
  • The histopathological diagnosis was adenocarcinoma, mature cystic teratoma with malignant transformation, stage IV.
  • Paclitaxel/carboplatin therapy was selected as adjuvant chemotherapy based on CD-DST results.
  • Upon completion of 6 courses, no increases in carcinomatous ascites or recurrent lesions were evident, and the chest wall tumor had disappeared completely.
  • CONCLUSION: The CD-DST may be particularly useful for selecting preoperative chemotherapeutic drugs for patients with ovarian cancer in which the histological type of the primary tumor is unknown.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols. Collagen Type I. Drug Screening Assays, Antitumor. Ovarian Neoplasms / drug therapy. Teratoma / drug therapy
  • [MeSH-minor] Aged. Antineoplastic Agents / administration & dosage. Carboplatin / administration & dosage. Female. Gels. Humans. Neoplasm Staging. Paclitaxel / administration & dosage. Pleural Effusion, Malignant

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • Hazardous Substances Data Bank. TAXOL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17308380.001).
  • [ISSN] 1421-9794
  • [Journal-full-title] Chemotherapy
  • [ISO-abbreviation] Chemotherapy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Collagen Type I; 0 / Gels; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
  •  go-up   go-down


11. Okada S, Ohaki Y, Inoue K, Nakajo H, Kawamata H, Kumazaki T: A case of dermoid cyst of the ovary with malignant transformation complicated with small intestinal fistula formation. Radiat Med; 2005 Sep;23(6):443-6
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of dermoid cyst of the ovary with malignant transformation complicated with small intestinal fistula formation.
  • Microscopic examination revealed a squamous cell carcinoma in the dermoid cyst wall.
  • The carcinoma had directly invaded the small intestine and a fistula between the cyst and the intestine was noted.
  • Thickened omentum showed granulomatous inflammation in the fatty tissue, but no metastases were detected.
  • The histopathological diagnosis was dermoid cyst with malignant transformation and invasion of the small intestine.
  • Chemotherapy was performed, but the patient died of progression of peritoneal metastases 10 months after the operation.
  • [MeSH-major] Carcinoma, Squamous Cell / radiography. Cell Transformation, Neoplastic. Dermoid Cyst / radiography. Intestinal Fistula / radiography. Ovarian Neoplasms / radiography

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16389989.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


12. Carver BS, Shayegan B, Serio A, Motzer RJ, Bosl GJ, Sheinfeld J: Long-term clinical outcome after postchemotherapy retroperitoneal lymph node dissection in men with residual teratoma. J Clin Oncol; 2007 Mar 20;25(9):1033-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term clinical outcome after postchemotherapy retroperitoneal lymph node dissection in men with residual teratoma.
  • PURPOSE: The histologic finding of teratoma occurs in approximately 40% of all postchemotherapy retroperitoneal lymph node dissections (PC-RPLND).
  • We evaluated patients at our institution undergoing initial PC-RPLND for teratoma to determine their clinical outcome.
  • PATIENTS AND METHODS: We identified 210 patients from 1989 to 2003 with nonseminomatous germ cell tumors (NSGCT) who underwent initial PC-RPLND and were found to have only teratoma in the retroperitoneum.
  • RESULTS: Of the 210 patients in our series, 192 (92%) received only induction chemotherapy, and 18 (9%) required additional chemotherapy regimens.
  • PC-RPLND pathology revealed mature teratoma in 178 patients (85%), immature teratoma in 15 patients (7%), and teratoma with malignant transformation in 17 patients (8%).
  • With a median follow-up time for survivors of 37 months, disease recurred in 30 patients.
  • Of the 30 patients with disease recurrence, 10 (33%) had recurrence with teratoma, five (17%) had recurrence with teratoma with malignant transformation, and 15 (50%) had recurrence with viable germ cell tumor.
  • Patients found to have teratoma at PC-RPLND have a 10-year probability of freedom from recurrence of 80%.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Lymph Node Excision. Retroperitoneal Neoplasms / secondary. Teratoma / secondary. Teratoma / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Combined Modality Therapy. Disease-Free Survival. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Lymph Nodes / pathology. Lymph Nodes / surgery. Male. Neoplasm Staging. Neoplasm, Residual. New York City / epidemiology. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Registries. Retroperitoneal Space. Risk Assessment. Time Factors. Treatment Outcome

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Clin Oncol. 2007 Mar 20;25(9):1024-5 [17261852.001]
  • (PMID = 17261854.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  •  go-up   go-down


13. Vuky J, Bains M, Bacik J, Higgins G, Bajorin DF, Mazumdar M, Bosl GJ, Motzer RJ: Role of postchemotherapy adjunctive surgery in the management of patients with nonseminoma arising from the mediastinum. J Clin Oncol; 2001 Feb 01;19(3):682-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The results of postchemotherapy surgical resection, frequency of viable tumor found during postchemotherapy surgery, and prognostic factors for survival were assessed.
  • Histologic analysis of resected residua postchemotherapy revealed viable tumor in 66%, teratoma in 22%, and necrosis in 12% of the specimens.
  • Viable tumor included embryonal carcinoma, choriocarcinoma, yolk sac carcinoma, seminoma, and teratoma with malignant transformation to nongerm cell histology (eg, sarcoma).
  • Clinical characteristics associated with a shorter survival after surgery included the presence of viable tumor in a resected specimen (P =.003) and more than one site resected during surgery (P =.06).
  • There were no statistically significant differences in survival for patients who underwent surgical resection with normal markers compared with patients with elevated serum tumor markers (P =.33).
  • A trend toward shorter survival was found in patients with increasing tumor markers before surgery compared with patients with normal and declining serum tumor markers (P =.09).
  • CONCLUSION: Surgical resection of residual mass after chemotherapy plays an integral role in the management of patients with primary mediastinal nonseminoma.
  • Teratoma and viable tumor were found in the majority of resected residua after chemotherapy.
  • Because patients who undergo conventional salvage chemotherapy programs rarely achieve long-term disease-free status, selected patients with elevated markers after chemotherapy are considered candidates for surgical resection.
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Chorionic Gonadotropin, beta Subunit, Human / blood. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Neoadjuvant Therapy. Prognosis. Prospective Studies. Randomized Controlled Trials as Topic. Survival Rate. alpha-Fetoproteins / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11157018.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-09207-23
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
  •  go-up   go-down


14. Oldenburg J, Wahlqvist R, Fosså SD: Late relapse of germ cell tumors. World J Urol; 2009 Aug;27(4):493-500
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To assess the main characteristics of late relapsing malignant germ cell tumors (MGCTs).
  • These tumors are rare and occur by definition 2 years or later after successful treatment.
  • METHODS: We present relevant literature on relapsing MGCT in order to highlight the following issues: incidence, impact of initial treatment on the subsequent risk of late relapse, treatment, and survival.
  • The retroperitoneal space is the predominant site of relapse in both histological types.
  • The initial treatment is important for the risk and localization of late relapses.
  • Patients with single site teratoma are usually cured by surgery alone, whereas viable MGCT or teratoma with malignant transformation may require multimodal treatment with chemo- and/or radiotherapy as well as surgery.
  • Surgery is the most important part in the treatment of late relapses.
  • Salvage chemotherapy should, if feasible, be based on a representative biopsy.
  • Five-year cancer-specific survival is above 50% in the recent large series and reaches 100% in case of single site teratoma.
  • CONCLUSIONS: Treatment of late relapsing MGCT patients is challenging and should be performed in experienced centers only.
  • Referral of late relapsing patients to high-volume institutions ensures the best chances of cure and enables multimodal treatment, and contributes to increased knowledge of tumor biology as well experience with the clinical course of these patients.
  • [MeSH-minor] Combined Modality Therapy. Humans. Male. Teratoma / drug therapy. Teratoma / secondary. Teratoma / surgery. Testicular Neoplasms / drug therapy. Testicular Neoplasms / pathology. Testicular Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Oncol. 2006 Dec 10;24(35):5503-11 [17158535.001]
  • [Cites] Eur Urol. 2008 Mar;53(3):478-96 [18191324.001]
  • [Cites] J Clin Oncol. 1997 Feb;15(2):594-603 [9053482.001]
  • [Cites] Lancet. 2005 Jul 23-29;366(9482):293-300 [16039331.001]
  • [Cites] J Clin Oncol. 2008 Dec 1;26(34):5647-8 [18981457.001]
  • [Cites] BJU Int. 2003 Apr;91(6):469-73 [12656895.001]
  • [Cites] Lancet. 2005 Jul 23-29;366(9482):267-8 [16039313.001]
  • [Cites] Cancer. 2007 Sep 15;110(6):1235-40 [17665498.001]
  • [Cites] Eur Urol. 2008 Mar;53(3):497-513 [18191015.001]
  • [Cites] Eur Urol. 2005 Jan;47(1):64-71 [15582251.001]
  • [Cites] J Clin Oncol. 1995 May;13(5):1170-6 [7537800.001]
  • [Cites] J Urol. 1997 Mar;157(3):860-2 [9072586.001]
  • [Cites] J Clin Oncol. 2000 Jan;18(2):358-62 [10637250.001]
  • [Cites] Ann Oncol. 1997 Jan;8(1):41-7 [9093706.001]
  • [Cites] J Clin Oncol. 2005 Apr 20;23(12):2781-8 [15837993.001]
  • [Cites] J Clin Oncol. 2007 Oct 1;25(28):4365-9 [17906201.001]
  • [Cites] Eur Urol. 2004 Jun;45(6):754-59; discussion 759-60 [15149748.001]
  • [Cites] J Urol. 2005 Mar;173(3):824-9 [15711278.001]
  • [Cites] J Clin Oncol. 2007 Dec 10;25(35):5603-8 [17998544.001]
  • [Cites] J Clin Oncol. 2004 Mar 15;22(6):1034-9 [15020605.001]
  • [Cites] Eur J Cancer. 1993;29A(14):1931-4 [8280484.001]
  • [Cites] Urology. 2009 Feb;73(2):328-31; discussion 331-2 [19022490.001]
  • [Cites] J Clin Oncol. 2006 Dec 10;24(35):5482-92 [17158533.001]
  • [Cites] Ann Oncol. 2008 Mar;19(3):443-7 [18048383.001]
  • [Cites] J Urol. 2002 Nov;168(5):1975-9 [12394688.001]
  • [Cites] Br J Cancer. 2006 Mar 27;94(6):820-7 [16508636.001]
  • [Cites] Cancer. 2002 Aug 1;95(3):520-30 [12209744.001]
  • [Cites] J Clin Oncol. 2008 Dec 1;26(34):5524-9 [18936477.001]
  • [Cites] Am J Surg Pathol. 2000 Feb;24(2):257-73 [10680894.001]
  • [Cites] Br J Urol. 1990 Jan;65(1):61-7 [1690070.001]
  • [Cites] J Clin Oncol. 2005 Sep 20;23(27):6549-55 [16170162.001]
  • [Cites] J Urol. 2009 Feb;181(2):627-32; discussion 632-3 [19091344.001]
  • [Cites] Can J Urol. 2005 Apr;12(2):2575-80 [15877938.001]
  • [Cites] J Clin Oncol. 2003 Jan 1;21(1):113-22 [12506179.001]
  • [Cites] Eur Urol. 2009 Jan;55(1):217-24 [18926622.001]
  • [Cites] Eur J Cancer. 1995 Sep;31A(10):1599-604 [7488408.001]
  • [Cites] J Clin Oncol. 2007 Mar 20;25(9):1033-7 [17261854.001]
  • [Cites] Urology. 2004 Mar;63(3):550-5 [15028456.001]
  • [Cites] Cancer. 2007 Jun 1;109(11):2248-56 [17437287.001]
  • [Cites] J Clin Oncol. 1999 Apr;17(4):1146 [10561173.001]
  • [Cites] Br J Urol. 1993 Mar;71(3):326-35 [8386580.001]
  • [Cites] Urology. 2000 Jan;55(1):102-6 [10654903.001]
  • [Cites] J Natl Cancer Inst. 1999 May 19;91(10):839-46 [10340903.001]
  • [Cites] J Urol. 2007 Mar;177(3):937-42; discussion 942-3 [17296380.001]
  • [Cites] J Urol. 1995 Oct;154(4):1370-2 [7658541.001]
  • [Cites] Br J Cancer. 2000 Oct;83(7):863-9 [10970686.001]
  • [Cites] Expert Rev Anticancer Ther. 2005 Oct;5(5):869-74 [16221056.001]
  • [Cites] J Clin Oncol. 2002 Nov 15;20(22):4448-52 [12431967.001]
  • [Cites] J Clin Oncol. 1993 Feb;11(2):324-9 [8381163.001]
  • [Cites] J Clin Oncol. 2007 Dec 10;25(35):5597-602 [18065732.001]
  • [Cites] J Clin Oncol. 2003 Mar 15;21(6):1101-6 [12637477.001]
  • [Cites] J Clin Oncol. 1998 Jan;16(1):290-4 [9440755.001]
  • [Cites] J Clin Oncol. 2008 Nov 20;26(33):5416-21 [18936476.001]
  • [Cites] J Clin Oncol. 2003 Sep 1;21(17 ):3310-7 [12947067.001]
  • [Cites] Cancer. 2002 Mar 15;94(6):1668-76 [11920527.001]
  • [Cites] Crit Rev Oncol Hematol. 2007 Dec;64(3):182-97 [17644403.001]
  • [Cites] Can J Urol. 2002 Oct;9(5):1637-40 [12431325.001]
  • (PMID = 19373473.001).
  • [ISSN] 1433-8726
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 58
  •  go-up   go-down


15. Necchi A, Colecchia M, Nicolai N, Mego M, De Giorgi U, Mikuz G, Sava T, Di Nicola M, Pastorino U, Salvioni R: Somatic malignant differentiation in adult male germ-cell tumors (GCTs): Preliminary evidences from the INTera database (International Project for Teratoma with Malignant Transformation). J Clin Oncol; 2009 May 20;27(15_suppl):e16013

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Somatic malignant differentiation in adult male germ-cell tumors (GCTs): Preliminary evidences from the INTera database (International Project for Teratoma with Malignant Transformation).
  • : e16013 Background: Malignant transformation (MT) is a rare phenomenon characterized by a neoplastic somatic differentiation within a GCT.
  • METHODS: Patients (pts) with a MT within GCT have been retrospectively identified from registries of contributing Institutions.
  • 25 pts had MT in primary tumor: 14 of them had no metastases (11 underwent primary retroperitoneal lymph-node dissection - RPLND), and 11 underwent chemotherapy (CT) ± surgery due to metastatic disease.
  • 6 of 11 pts undergoing chemotherapy remain disease-free following a median f-up of 155 months (8-297+).

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27962924.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


16. Brames M, Ehrlich Y, Einhorn L: Malignant transformation of teratoma to primitive neuroectodermal tumor (PNET): Outcome analysis with PNET based chemotherapy. J Clin Oncol; 2009 May 20;27(15_suppl):e16121

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of teratoma to primitive neuroectodermal tumor (PNET): Outcome analysis with PNET based chemotherapy.
  • Residual teratoma can be surgically resected.
  • However, testicular teratoma can differentiate along endodermal, ectodermal, or mesodermal elements (malignant transformation of teratoma), with capacity to metastasize and not be amenable to surgical resection.
  • We report results of malignant transformation of teratoma to metastatic PNET treated with PNET based chemotherapy.
  • RESULTS: 9 of 10 patients had at least 1 prior platinum based combination chemotherapy regimen for their germ cell tumor.
  • Tumor markers (human chorionic gonadotropin and alphafetoprotein) were normal at start of chemotherapy for biopsy proven PNET.
  • Two of 10 are currently disease-free for 16 and 33 months from initiation of PNET specific chemotherapy and 3 other patients are alive with disease at 73, 34, and 30 months.
  • CONCLUSIONS: PNET specific chemotherapy has a high objective response rate for malignant transformation of teratoma to PNET, with some patients capable of long-term survival with chemotherapy followed by surgical resection.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27963389.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


17. Foster R, Ehrlich Y, Ulbright TM, Cheng L, Bihrle R, Beck SD, Andreoiu M, Brames MJ, Einhorn LH: Malignant transformation of teratoma to primitive neuroectodermal tumor (PNET): Outcome analysis with retroperitoneal lymph node dissection and PNET specific chemotherapy. J Clin Oncol; 2009 May 20;27(15_suppl):5081

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of teratoma to primitive neuroectodermal tumor (PNET): Outcome analysis with retroperitoneal lymph node dissection and PNET specific chemotherapy.
  • : 5081 Background: Malignant transformation of teratoma to PNET is a rare entity.
  • Surgical resection has been the mainstay of therapy because these tumors are not curable with cisplatin based chemotherapy.
  • We report long-term survival and potential cure with retroperitoneal lymph node dissection (RPLND) and PNET specific chemotherapy.
  • 74 had RPLND as part of initial treatment or at relapse.
  • PNET specific chemotherapy consisted of cyclophosphamide, doxorubicin, vincristine alternating with ifosfamide and etoposide.
  • 9 elected surveillance or adjuvant chemotherapy.
  • 10 of these were treated with PNET specific chemotherapy for unresectable disease.
  • 2 additional pts were treated with PNET specific chemotherapy as adjuvant to RPLND.
  • CONCLUSIONS: Malignant transformation of teratoma to PNET carries an adverse prognosis.
  • RPLND is an integral part of the therapeutic strategy.
  • PNET specific chemotherapy, adjuvant to RPLND or for treatment of unresectable disease followed by surgery, may result in long-term survival and potential cure.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27964284.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


18. Takami M, Maruyama A, Fukai H, Matsumoto H, Togo Y, Takimoto T, Sakamoto H, Yamamoto T: [A case of synchronous double cancer responding to UFT--dermoid cyst with secondary malignant transformation and uterine endometrial adenocarcinoma]. Gan To Kagaku Ryoho; 2005 Jan;32(1):103-6
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of synchronous double cancer responding to UFT--dermoid cyst with secondary malignant transformation and uterine endometrial adenocarcinoma].
  • We report here a case of synchronous dermoid cyst with secondary malignant tumor and uterine endometrial adenocarcinoma that responded to UFT.
  • The pathological findings were dermoid cyst with secondary malignant transformation.
  • After the operation she had underwent cyclic chemotherapy with CDDP, CPA, THP and 5-FU.
  • After three cycles of chemotherapy, a uterine recurrence was suspected from her uterine endocervical smear test.
  • The pathological findings were primary uterine endometrial adenocarcinoma, not metastasis from dermoid cyst with secondary malignant tumor.
  • After the second operation, she was treated with oral UFT (400 mg/day), as she refused chemotherapy and radiotherapy.
  • Two months after the start of UFT, the tumor markers were reduced remarkably, and the patient maintained good QOL throughout the treatment without serious adverse events.
  • We conclude that UFT might be benefical in the treatment of advanced gynecologic cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Agents / therapeutic use. Dermoid Cyst / drug therapy. Endometrial Neoplasms / drug therapy. Neoplasms, Multiple Primary. Ovarian Neoplasms / drug therapy. Tegafur / therapeutic use. Uracil / therapeutic use
  • [MeSH-minor] Adult. Carcinoma, Adenosquamous / pathology. Combined Modality Therapy. Drug Combinations. Female. Humans. Hysterotomy. Ovariectomy. Quality of Life. Salpingostomy

  • Genetic Alliance. consumer health - Endometrial cancer.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15675593.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Combinations; 0 / UFT(R) drug; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil
  •  go-up   go-down


19. Gainford MC, Tinker A, Carter J, Petru E, Nicklin J, Quinn M, Hammond I, Elit L, Lenhard M, Friedlander M: Malignant transformation within ovarian dermoid cysts: an audit of treatment received and patient outcomes. an Australia New Zealand gynaecological oncology group (ANZGOG) and gynaecologic cancer intergroup (GCIG) study. Int J Gynecol Cancer; 2010 Jan;20(1):75-81
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation within ovarian dermoid cysts: an audit of treatment received and patient outcomes. an Australia New Zealand gynaecological oncology group (ANZGOG) and gynaecologic cancer intergroup (GCIG) study.
  • INTRODUCTION: Malignant transformation in an ovarian dermoid cyst occurs in 1% to 2% of cases.
  • Our knowledge about this tumor type is limited and largely based on case reports.
  • We aimed to collate and analyze the cumulative experience of how these patients have been managed in an effort to identify the most appropriate treatment strategies.
  • Data collected included age, symptoms, stage, extent of surgery, chemotherapy and radiotherapy details, response to treatment, progression, survival, and salvage therapy.
  • Chemotherapy was not routinely given after surgery and did not seem to be effective.
  • At relapse, 2 patients had a sustained remission after secondary surgery for relapsed disease.
  • Second-line chemotherapy and radiotherapy were infrequently prescribed.
  • There is no standard adjuvant treatment, but platinum-based regimens are most commonly used.
  • However, regardless of treatment received, patients with advanced disease do poorly.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Dermoid Cyst / pathology. Dermoid Cyst / therapy. Ovarian Neoplasms / pathology. Ovarian Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Australia. Clinical Audit. Female. Gynecology / methods. Humans. International Cooperation. Middle Aged. New Zealand. Prognosis. Societies, Medical. Treatment Outcome. Young Adult

  • Genetic Alliance. consumer health - Ovarian cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20130506.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] United States
  •  go-up   go-down


20. Tangjitgamol S, Manusirivithaya S, Sheanakul C, Leelahakorn S, Thawaramara T, Jesadapatarakul S: Squamous cell carcinoma arising from dermoid cyst: Case reports and review of literature. Int J Gynecol Cancer; 2003 Jul-Aug;13(4):558-63
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell carcinoma arising from dermoid cyst: Case reports and review of literature.
  • Malignant transformation of a dermoid cyst is rare, with squamous cell carcinoma (SCC) being the most common type.
  • During a 10-year period in our institution, we encountered only four cases of SCC out of 425 cases of dermoid cyst, an incidence of 0.94%.
  • Three were in early stage and have survived to date without evidence of disease at 8, 12, and 116 months after diagnosis.
  • The other case, in stage III, had suboptimal surgery and responded partially to chemotherapy, subsequently progressed after cessation of the drug, and finally died within a year after diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic / pathology. Dermoid Cyst / pathology. Ovarian Cysts / pathology. Ovarian Neoplasms / pathology. Pelvic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Fatal Outcome. Female. Follow-Up Studies. Humans. Hysterectomy. Middle Aged. Ovariectomy. Precancerous Conditions / pathology. Risk Assessment

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • MedlinePlus Health Information. consumer health - Ovarian Cysts.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12911740.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
  •  go-up   go-down


21. Porcaro AB, Antoniolli SZ, Martignoni G, Brunelli M, Curti P: Adult primary teratoma of the testis--report on 5 cases in clinical stage I disease. Int Urol Nephrol; 2001;33(4):657-9
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult primary teratoma of the testis--report on 5 cases in clinical stage I disease.
  • OBJECTIVES: Testis pure teratoma accounts for 2.7% to 3% of all germ cell tumors in adult where it behaves as a malignant neoplasm.
  • Pure teratoma of the testis presents in clinical stage I disease in 44% of the patients whose risk of having pathological stage II disease is 16.7% to 19.2%.
  • Herein we report on 5 cases of adult pure teratoma of the testis presenting itself in clinical stage I disease.
  • Testis pure teratoma was detected in 5 patients (7%).
  • Testis tumor markers were evaluated in all cases.
  • Treatment options after orchidectomy included retroperitoneal lymph node dissection (RPLND) in 4 patients and surveillance in 1.
  • The tumor was on the left sided in 3 cases (60%) and right in 2 (40%).
  • Tumor average size was 3.2 cm (rang 1-6).
  • Histopathology detected the following subtypes: mature teratoma in 3 cases (60%), immature teratoma in 1 (20%) and teratoma with malignant transformation in (20%).
  • CONCLUSIONS: Primary pure teratoma of the testis does not respond to chemotherapy nor does it to radiation therapy.
  • The disease treatment options after orchidectomy for patients with clinical stage I disease include RPLND or surveillance with their relative risks and benefits.
  • RPLND is the chosen treatment because it is both staging and treating.
  • A close a long term follow up is required since pure teratoma metastatic disease may clinically develop after more than 10 years.
  • [MeSH-major] Orchiectomy. Teratoma / surgery. Testicular Neoplasms / surgery

  • Genetic Alliance. consumer health - Teratoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Urol Clin North Am. 1999 Aug;26(3):595-609 [10494291.001]
  • [Cites] J Urol. 1975 Oct;114(4):636-9 [1235398.001]
  • [Cites] Prog Clin Biol Res. 1990;357:267-76 [2217471.001]
  • [Cites] J Urol. 1996 Mar;155(3):939-42 [8583612.001]
  • [Cites] Acta Radiol Oncol. 1984;23(4):239-47 [6093440.001]
  • [Cites] Lancet. 1987 Aug 8;2(8554):294-8 [2886764.001]
  • [Cites] J Urol. 1986 May;135(5):1020-2 [3959229.001]
  • [Cites] Virchows Arch. 2000 Jun;436(6):608-16 [10917177.001]
  • [Cites] J Clin Oncol. 1992 Apr;10(4):564-8 [1312585.001]
  • [Cites] Am J Surg Pathol. 1997 Aug;21(8):896-904 [9255252.001]
  • [Cites] Am J Surg Pathol. 1993 Nov;17(11):1075-91 [8214253.001]
  • [Cites] J Urol. 1997 Jan;157(1):160-3 [8976241.001]
  • [Cites] J Urol. 1998 Mar;159(3):859-63 [9474169.001]
  • [Cites] J Urol. 1998 Jan;159(1):133-8 [9400455.001]
  • [Cites] Cancer. 1995 May 1;75(9):2244-50 [7712432.001]
  • [Cites] Br J Urol. 1991 Feb;67(2):195-202 [2004236.001]
  • [Cites] Cancer. 1985 Aug 15;56(4):860-3 [2990657.001]
  • [Cites] Urol Clin North Am. 1993 Feb;20(1):145-52 [8434433.001]
  • [Cites] Cancer. 1988 Sep 15;62(6):1202-6 [2842034.001]
  • [Cites] Br J Urol. 1994 Jun;73(6):701-6 [8032840.001]
  • (PMID = 12452623.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  •  go-up   go-down


22. Schneider BP, Kesler KA, Brooks JA, Yiannoutsos C, Einhorn LH: Outcome of patients with residual germ cell or non-germ cell malignancy after resection of primary mediastinal nonseminomatous germ cell cancer. J Clin Oncol; 2004 Apr 1;22(7):1195-200
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To identify prognostic variables and outcomes in patients with primary mediastinal nonseminomatous germ cell tumor (PMNSGCT) with postchemotherapy resection of persistent cancer.
  • RESULTS: At diagnosis, 43 patients had elevated serum tumor markers (STMs), and 20 had extramediastinal disease.
  • After resection, 26 patients had germ cell tumors (GCT), 12 had malignant transformation of teratoma with elements of non-GCT, and nine had both GCT and non-GCT.
  • Seven of 21 patients with elevated STMs at time of resection have continuously NED.
  • Sixteen patients received adjuvant chemotherapy, and seven have continuously NED.
  • Overall, 16 of 47 patients have continuously NED, an additional four patients have NED with further therapy (currently NED), two patients are alive with disease, 23 patients died of disease, and two patients died postoperatively.
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chorionic Gonadotropin, beta Subunit, Human / blood. Humans. Middle Aged. Neoplasm, Residual. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome. alpha-Fetoproteins / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15051766.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
  •  go-up   go-down


23. Biskup W, Calaminus G, Schneider DT, Leuschner I, Göbel U: Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96. Klin Padiatr; 2006 Nov-Dec;218(6):303-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96.
  • BACKGROUND: The designation of a teratoma with malignant transformation (TMT) refers to the occurrence of somatic non-germ cell malignancies within a teratoma.
  • PATIENTS AND METHODS: Between 1982 and 2003, 641 patients with extracranial nontesticular pure teratoma (256 coccygeal, 246 ovarian, 139 other sites) were reported to the MAKEI protocols 83/86/89/96 by various, mainly German centres.
  • Patients with teratoma and somatic malignancy were identified by database queries.
  • Patients with malignant germ cell tumor components were excluded from this analysis.
  • Resection was performed in seven patients (including both coccygeal tumors) and adjuvant chemotherapy was administered in one of them.
  • Two patients relapsed after resection, but both were cured with chemotherapy.
  • Two patients suffered from advanced tumors and both were treated with primary chemotherapy.
  • One patient was cured from the malignant component (astrocytoma), but the teratomatous components persisted.
  • The other patient died as a result of progression of her malignant medulloepithelioma.
  • CONCLUSIONS: Malignant transformation of pure teratomas constitutes a very rare entity in children and adolescents that is most commonly observed in postpubertal girls with ovarian teratoma.
  • Compared to adult patients, similar malignant entities can be observed in association with teratoma.
  • In localised tumors, complete resection appears to be adequate, whereas chemotherapy should be considered in patients with R1- or R2-resection.
  • Cisplatinum-based chemotherapy was effective as two of four relapsed patients survived tumor free.
  • However, the ideal regimen has not yet been established and the known sensitivity of the histologic components to cytostatic drugs has to be considered in the choice of treatment.
  • [MeSH-major] Ovarian Neoplasms. Teratoma
  • [MeSH-minor] Adolescent. Adult. Age Factors. Antineoplastic Combined Chemotherapy Protocols. Chemotherapy, Adjuvant. Child. Child, Preschool. Cytogenetic Analysis. Female. Humans. Infant. Infant, Newborn. Middle Aged. Neoplasm Staging. Neoplasms, Germ Cell and Embryonal / pathology. Ovary / pathology. Sacrococcygeal Region / pathology. Treatment Outcome

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17080331.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  •  go-up   go-down


24. Mikuz G: [WHO classification of testicular tumors]. Verh Dtsch Ges Pathol; 2002;86:67-75
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most important is obviously the precursor lesion of germ cell tumors, which has been called "intratubular malignant germ cells".
  • Such atypical cells appear in the tubules adjacent to the germ cell tumors, in some few cases (6%) also in the contra lateral healthy gonad and rarely in infertile men (1%).
  • The precursor lesion can progress to franc germ cell tumor starting probably with seminoma, which still maintain the capability of differentiation (pluripotente cells) in all other types of non-seminomatous germ cell tumors.
  • In the group of mature teratomas the "dermoid cyst" appears as a benign subtype mostly observed in children.
  • Unfortunately, however, the old term "teratoma with malignant transformation" was changed to "teratoma with malignant areas" in the 1998 classification.
  • This is a harmless name for an extremely dangerous tumor in which one tissue overgrows the other and gives rise to somatic type sarcomas or carcinomas.
  • Such tumors do not respond like germ cell tumors to the usual chemotherapy.
  • Treatment should be tailored according to that used in standard management of the respective sarcoma or carcinoma.
  • In the comments it is mentioned that the testis carcinoid could be a part of teratoma, but the diagnosis is listed in the group of "miscellaneous" tumors together with tumors of ovarian epithelial type.
  • This is a very questionable decision because the normal testis does not contain neuroendocrine cells from which carcinoids would have to be able to develop.
  • "Large cell calcifying Sertoli cell tumour" has been recently described and can be sporadic or inherited.
  • This morphologically peculiar tumor can be part of the Swiss syndrome also called Carney's complex.
  • The patients have cardiac myxomas, spotty skin pigmentation, hormone active nodular hyperplasia of the adrenals and soft tissue myxomas.
  • For the therapy of germ cell tumor an assessment of risk factors found by the pathologists is extremely important.
  • The most important independent predictors of relapse are tumor invasion of blood or lymph-vessels, absence of yolk sac elements and the presence of an embryonal carcinoma component.
  • In the absence of such predictors a surveillance policy allows some patients to forgo chemotherapy.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12647353.001).
  • [ISSN] 0070-4113
  • [Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie
  • [ISO-abbreviation] Verh Dtsch Ges Pathol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 48
  •  go-up   go-down


25. Sanghera P, El Modir A, Simon J: Malignant transformation within a dermoid cyst: a case report and literature review. Arch Gynecol Obstet; 2006 Jun;274(3):178-80
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation within a dermoid cyst: a case report and literature review.
  • Malignant transformation within a dermoid cyst is a rare event.
  • The most common transformation is to squamous cell carcinoma.
  • We present a case of locally invasive squamous cell carcinoma arising from a dermoid cyst in a 48-year-old lady.
  • Within 2 months of the surgery she had recurrent disease and this was resistant to single agent carboplatin chemotherapy.
  • We discuss the difficulties in diagnosing such tumours, the poor prognosis and review the various adjuvant treatment strategies that have been used in attempt to improve the outcome.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Dermoid Cyst / pathology. Ovarian Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16525791.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 14
  •  go-up   go-down






Advertisement