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Items 1 to 25 of about 25
1. Manduch M, Dexter DF, Ellis PM, Reid K, Isotalo PA: Extraskeletal Ewing's sarcoma/primitive neuroectodermal tumor of the posterior mediastinum with t(11;22)(q24;q12). Tumori; 2008 Nov-Dec;94(6):888-91
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  • [Title] Extraskeletal Ewing's sarcoma/primitive neuroectodermal tumor of the posterior mediastinum with t(11;22)(q24;q12).
  • Ewing's sarcoma/primitive neuroectodermal tumor family of tumors is part of a rare group of malignant neoplasms with small round-cell morphology.
  • A chest radiograph and magnetic resonance imaging demonstrated an extraosseous, dumbbell-shaped mass of the posterior mediastinum with extension into the spinal canal.
  • The patient underwent a left posterolateral thoracotomy and a T3-5 laminectomy with subsequent multi-agent chemotherapy.
  • Histopathologic examination of the tumor demonstrated sheets of primitive small round malignant cells that showed no visible differentiation.
  • The neoplasm was diagnosed as a Ewing's sarcoma/primitive neuroectodermal tumor, and cytogenetic studies confirmed a t(11;22)(q24;q12) chromosomal translocation and an associated trisomy of chromosome 2, supporting the histologic diagnosis.
  • Although rare, they need to be considered in the differential diagnosis of primary mediastinal tumors.
  • [MeSH-major] Chromosomes, Human, Pair 11 / genetics. Chromosomes, Human, Pair 22 / genetics. Mediastinum / pathology. Neuroectodermal Tumors, Primitive / genetics. Sarcoma, Ewing / genetics. Translocation, Genetic / genetics
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Immunoenzyme Techniques. Karyotyping. Magnetic Resonance Imaging. Spinal Neoplasms / genetics. Spinal Neoplasms / pathology. Young Adult

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  • (PMID = 19267114.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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2. Feng C, Tang SQ, Wang JW, Liu Y, Yang G: [Curative effects of the protocol of CDV combined with CiE as pre-operative chemotherapy in high-risk childhood neuroblastoma]. Zhongguo Dang Dai Er Ke Za Zhi; 2009 Nov;11(11):885-7
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  • [Title] [Curative effects of the protocol of CDV combined with CiE as pre-operative chemotherapy in high-risk childhood neuroblastoma].
  • OBJECTIVE: To evaluate the effects and the toxicity of the protocol of CDV combined with CiE as pre-operative chemotherapy in childhood stage IV neuroblastoma.
  • The primary sites of the diseases were abdomen (n = 21), posterior mediastinum (n = 4) and pelvic cavity (n = 2).
  • Neuroblastoma therapeutic response evaluation criterion and common terminology criteria for adverse events of National Cancer Institute were used to evaluate effects and chemotherapy related toxicity.
  • RESULTS: All patients received the pre-operative chemotherapy.
  • After chemotherapy, 24 patients received operations.
  • Total resection of primary tumor was found in 14 patients (58%) and part resection in 10 patients (42%).
  • The most common chemotherapy related toxicity was bone marrow suppression: grade IV suppression of neutrophils (n = 27), reduction in hemoglobin (III grade, n = 7; IV grade, n = 20) and reduction in platelet (III grade, n = 2; IV grade, n = 25).
  • I or II grade lesions of digestive, liver and kidney were found and could be recovered after therapy.
  • CONCLUSIONS: The protocol of CDV combined with CiE as pre-operative chemotherapy might be effective in children with stage IV neuroblastoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neuroblastoma / drug therapy

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  • (PMID = 20113653.001).
  • [ISSN] 1008-8830
  • [Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
  • [ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 7GR28W0FJI / Dacarbazine; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin; CVD protocol
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3. Ko SF, Tsai YH, Huang HY, Ng SH, Fang FM, Tang Y, Sung MT, Hsieh MJ: Retrotracheal thymoma masquerading as esophageal submucosal tumor. World J Gastroenterol; 2005 May 28;11(20):3165-6
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  • [Title] Retrotracheal thymoma masquerading as esophageal submucosal tumor.
  • Computed tomography and magnetic resonance imaging revealed an elongated mass in the retrotracheal region of the lower neck with extension to the posterior mediastinum.
  • Partial tumor resection and histopathological evaluation revealed a WHO type B2 thymoma.
  • Adjuvant radiation and chemotherapy were subsequently administered resulting in complete tumor regression.
  • To our knowledge, this is the first report of ectopic retrotracheal thymoma with clinical and imaging manifestations mimicking those for esophageal submucosal tumor.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Thymoma / diagnosis. Thymus Neoplasms / diagnosis
  • [MeSH-minor] Adult. Deglutition Disorders / etiology. Diagnosis, Differential. Hoarseness / etiology. Humans. Male

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  • (PMID = 15918212.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4305862
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4. Hasegawa Y, Tomita K, Hashimoto K, Shigeoka Y, Watanabe M, Yamasaki A, Shimizu E: Des-gamma-carboxy prothrombin (PIVKA-II)-producing mediastinal embryonal carcinoma with features of hepatoid differentiation. Anticancer Res; 2005 Nov-Dec;25(6C):4569-71
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  • [Title] Des-gamma-carboxy prothrombin (PIVKA-II)-producing mediastinal embryonal carcinoma with features of hepatoid differentiation.
  • The case of a 48-year-old man with primary nonseminomatous embryonal carcinoma at the posterior mediastinum is described.
  • The patient displayed extremely high plasma levels of Des-gamma-carboxy prothrombin (PIVKA-II) (4040 mAU/ml).
  • Ultrasonography and dynamic computed tomography ruled out hepatocellular carcinoma (HCC) or liver metastasis.
  • After preoperative systemic chemotherapy, total tumor resection was performed.
  • These results indicate that tumor cells, which are manifested as hepatoid differentiation, may produce PIVKA-II.
  • [MeSH-minor] Cell Differentiation / physiology. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged. Prothrombin

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  • (PMID = 16334143.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Protein Precursors; 53230-14-1 / acarboxyprothrombin; 9001-26-7 / Prothrombin
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5. Leshnower BG, Morris RJ, Pechet TT: Management of an anterior mediastinal pheochromocytoma causing tracheomalacia. Ann Thorac Surg; 2007 Dec;84(6):2088-90
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  • Surgical excision is the optimal treatment of these tumors as they are resistant to chemotherapy and radiation therapy.
  • Although these tumors are most commonly found in the abdomen, 10% of paraganagliomas are located in the thorax, usually in the posterior mediastinum.
  • Occasionally these tumors present in the anterior mediastinum, which can pose a significant surgical challenge due to the proximity of the great vessels and airway.
  • In this report we describe the treatment of an anterior mediastinal pheochromocytoma that presented with tracheal obstruction and required pulmonary artery reconstruction and airway stenting.

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  • (PMID = 18036944.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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6. Hsu CH, Lee CM, Wang FC, Fang CL: Neurofibroma with increased uptake of [F-18]-fluoro-2 deoxy-D-glucose interpreted as a metastatic lesion. Ann Nucl Med; 2003 Oct;17(7):609-11
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  • We report a patient with a solitary spinal neurofibroma in the posterior mediastinum interpreted as a metastatic tumor.
  • A 46-year-old female with rectal cancer who had undergone operation and subsequent adjuvant chemotherapy two years previously was referred to our department for a follow-up whole body FDG-PET study.
  • PET scan revealed a mass with increased uptake of FDG (SUV = 4.6) in the posterior mediastinum.
  • MRI examination showed a dumbbell neurogenic tumor originating from the intercostal nerve at T6 level.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Intercostal Nerves / pathology. Intercostal Nerves / radionuclide imaging. Middle Aged. Radiopharmaceuticals. Rectal Neoplasms / radionuclide imaging. Rectal Neoplasms / surgery

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  • (PMID = 14651363.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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7. Heffernan E, Fennelly D, Collins CD: Multiple metastases to skeletal muscle from carcinoma of the esophagus detected by FDG PET-CT imaging. Clin Nucl Med; 2006 Dec;31(12):810-1
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  • A 67-year-old woman was treated with neoadjuvant chemotherapy, esophagectomy, and subsequent radiotherapy for T3N1 poorly differentiated adenocarcinoma of the esophagus.
  • Five months after surgery, a routine follow-up CT demonstrated a 1.2-cm soft tissue mass in the posterior mediastinum suspicious for local recurrence.
  • An FDG-PET/CT study confirmed tumor in the posterior mediastinum and also showed focal areas of increased tracer uptake within several muscles.
  • Skeletal muscle is one of the most unusual sites of metastatic disease, although it is probable that the more frequent use of FDG-PET imaging will lead to an increase in the detection of such lesions.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Esophageal Neoplasms / diagnosis. Fluorodeoxyglucose F18. Muscle Neoplasms / diagnosis. Muscle Neoplasms / secondary. Tomography, X-Ray Computed / methods

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  • (PMID = 17117081.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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8. Nagashima O, Takahashi K, Sato K, Suzuki T, Fukuchi Y, Isobe Y, Oshimi K: [Case of malignant lymphoma arising from the posterior mediastinum, with pleural effusion]. Nihon Kokyuki Gakkai Zasshi; 2004 Aug;42(8):772-6
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  • [Title] [Case of malignant lymphoma arising from the posterior mediastinum, with pleural effusion].
  • We report a rare case of malignant lymphoma arising from the posterior mediastinum with bilateral pleural effusion.
  • A 71-year-old man was admitted to our hospital for evaluation of a posterior mediastinal tumor and bilateral pleural effusion revealed on a chest CT scan.
  • Because no tumor tissue could be obtained by fiberbronchoscopy, video-assisted thoracoscopic surgery was performed.
  • The tumor sample was composed of large, atypical lymphocytes positive for CD20 on immunohistochemical analysis.
  • A diagnosis of diffuse large B cell lymphoma was made from the typical histological features.
  • The patient was treated with combination chemotherapy (CHOP) and rituximab and improved dramatically.
  • [MeSH-major] Lymphoma, B-Cell / complications. Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / diagnosis. Mediastinal Neoplasms / complications. Mediastinal Neoplasms / diagnosis. Pleural Effusion, Malignant / complications
  • [MeSH-minor] Aged. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antigens, CD20 / analysis. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Biopsy / methods. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Humans. Male. Prednisolone / administration & dosage. Rituximab. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 15455953.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD20; 0 / Biomarkers, Tumor; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
  • [Number-of-references] 20
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9. Trainer S, Bergmann T, Bölükbas S, Weissbach L, Figge M, Schirren J: [The approach to tumors of the retrocrural mediastinum]. Chirurg; 2008 Jan;79(1):26-9

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  • [Title] [The approach to tumors of the retrocrural mediastinum].
  • [Transliterated title] Zugang zu retrokruralen Tumoren des Mediastinums.
  • Retrocrural tumors of the lower posterior mediastinum are rare.
  • From November 1999 to December 2005, using this approach we operated on 12 patients with residual germ cell tumors after chemotherapy.
  • [MeSH-major] Diaphragm / surgery. Mediastinal Neoplasms / surgery. Neoplasm, Residual / surgery. Neoplasms, Germ Cell and Embryonal / surgery
  • [MeSH-minor] Disease-Free Survival. Humans. Lymph Node Excision. Lymphatic Metastasis. Magnetic Resonance Imaging. Prognosis. Ribs / surgery. Teratoma / diagnosis. Teratoma / diagnostic imaging. Teratoma / secondary. Teratoma / surgery. Thoracotomy. Tomography, X-Ray Computed. Treatment Outcome

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  • [Cites] Semin Thorac Cardiovasc Surg. 1992 Oct;4(4):314-9 [1457572.001]
  • [Cites] Chest Surg Clin N Am. 2002 Nov;12(4):739-48 [12471875.001]
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  • [Cites] Chest Surg Clin N Am. 2002 Nov;12(4):695-706 [12471872.001]
  • [Cites] J Clin Oncol. 2004 Sep 15;22(18):3713-9 [15365067.001]
  • (PMID = 18209978.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 8
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10. Togashi K, Hosaka Y, Sato K: [Sarcomatoid pleural mesothelioma presenting as posterior mediastinal tumor with dysphagia]. Kyobu Geka; 2007 Jan;60(1):49-52
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  • [Title] [Sarcomatoid pleural mesothelioma presenting as posterior mediastinal tumor with dysphagia].
  • Radiological studies demonstrated a solid mass with a maximal diameter of 5cm at the posterior mediastinum.
  • The tumor was resected, then postoperative radiotherapy (60Gy) and chemotherapy were performed.
  • Results of histological and immunohistochemical study showed that the tumor consisted of sarcomatoid mesothelioma.
  • Case 2: A 76-year-old man with dysphagia, chest pain and cough admitted to our department Radiological studies demonstrated a solid mass with a maximal diameter of 12cm in the posterior mediastinum. accompanied by abundant effusion in the bilateral pleural cavities.
  • The patient underwent open biopsy and histological and immunohistochemical study showed that the tumor consisted of sarcomatoid mesothelioma.
  • We report extremely rare cases of sarcomatoid mesothelioma that appeared to be posterior mediastinal tumor before surgery, and discuss the difficulty of diagnosing sarcomatoid mesothelioma with atypical clinical manifestations.
  • [MeSH-major] Deglutition Disorders / complications. Mediastinal Neoplasms / diagnosis. Mesothelioma / diagnosis. Pleural Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 17249539.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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11. Larena-Avellaneda A, Debus ES, Klein I, Grasshoff S, Höcht B: [Epidural pneumatosis and spontaneous pneumomediastinum: differential diagnosis with respect to the Boerhaave syndrome]. Zentralbl Chir; 2008 Feb;133(1):79-81
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  • [Title] [Epidural pneumatosis and spontaneous pneumomediastinum: differential diagnosis with respect to the Boerhaave syndrome].
  • We report on the case of a 15-year-old female who developed a pneumomediastinum after heavy vomiting.
  • In the CT of the chest, air was detected in the mediastinum and in the epidural space (epidural pneumatosis).
  • The patient recovered uneventfully with conservative treatment.
  • The air in the spinal canal arrives by migration through the intervertebral foramina from the posterior mediastinum and neck, where the fascial barrier is missing.
  • Therapy consists of symptomatic, conservative treatment.
  • [MeSH-major] Emphysema / etiology. Epidural Space. Esophageal Perforation / radiography. Mediastinal Emphysema / radiography. Tomography, X-Ray Computed. Vomiting / complications
  • [MeSH-minor] Adolescent. Anti-Bacterial Agents / therapeutic use. Diagnosis, Differential. Drug Therapy, Combination. Female. Humans

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  • (PMID = 18278708.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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12. Landolsi A, Tarmiz H, Ben Fatma L, Kallel L, Gharbi O, Kraïem C, Korbi S, Ben Ahmed S: [Diagnosis and treatment of primary germ cell tumors of the mediastinum. Report of six cases]. Tunis Med; 2003 Jun;81(6):419-24

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  • [Title] [Diagnosis and treatment of primary germ cell tumors of the mediastinum. Report of six cases].
  • [Transliterated title] Diagnostic et traitement des tumeurs germinales malignes primitives du mediastin. A propos de six cas.
  • Primary germ cell tumours of the mediastinum are rare.
  • The tumor site was the posterior mediastinum in two patients and anterior in the remaining cases.
  • At histologic exam we found two cases of seminoma, one embryonal carcinoma, one case of yolk sac tumor and two cases of composite tumor.
  • All patients had non metastatic but locally advanced disease at diagnosis.
  • Three patients were treated with cisplatin based chemotherapy followed by radiotherapy or surgical resection of residual masses.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / therapy. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / therapy

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  • (PMID = 14534949.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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13. Petersdorf SH, Wood DE: Lymphoproliferative disorders presenting as mediastinal neoplasms. Semin Thorac Cardiovasc Surg; 2000 Oct;12(4):290-300
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  • The mediastinum is an uncommon location for presentation of these heterogeneous disorders, but involvement of the mediastinum may be the sole site of disease for several aggressive lymphomas.
  • Both Hodgkin's disease and non-Hodgkin's lymphoma may present in the mediastinum.
  • The most common types of non-Hodgkin's lymphoma involving the mediastinum include lymphoblastic lymphoma and mediastinal large cell lymphoma.
  • These lymphomas most commonly develop in the anterior mediastinum but may be seen in the middle and posterior mediastinum.
  • Symptoms associated with a mediastinal presentation of a lymphoproliferative disorder are often attributable to compression of mediastinal structures (eg, superior vena cava syndrome) or invasion of thoracic structures such as the pericardium or pleura.
  • Although staging can be performed with routine imaging studies, surgical intervention is often required to ensure accurate histologic diagnosis of these lymphomas.
  • Once a diagnosis has been established, therapeutic modalities usually include chemotherapy and/or radiotherapy.
  • [MeSH-minor] Humans. Neoplasm Staging

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  • [Copyright] Copyright 2000 by W.B. Saunders Company
  • (PMID = 11154724.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] UNITED STATES
  • [Number-of-references] 41
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14. Stremmel C, Passlick B: [Surgery of mediastinal tumors]. Chirurg; 2008 Jan;79(1):9-10, 12-7
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  • Thymomas, lymphomas, and germ cell tumors are the most frequent lesions of the anterior mediastinum, whereas endodermal (bronchogenic) cysts and lymphomas are the most frequent lesions of the middle mediastinum.
  • In the posterior mediastinum, neurogenic tumors and soft-tissue sarcomas are the most frequent.
  • Depending on tumor location, mediastinoscopy, mediastinotomy, and thoracoscopy are the preferred diagnostic methods.
  • Surgical treatment of thymoma is the gold standard, and median sternotomy is the most frequently applied approach.
  • The decisive prognostic and therapeutic criteria are Masaoka staging, WHO classification, and R0 status.
  • Surgical treatment is highly recommended in patients with locally recurrent tumors.
  • The importance of surgical treatment of germ cell tumors is determined by a negative concentration of beta-HCG and alpha-fetoprotein and in cases of residual tumor after chemotherapy.
  • Bronchogenic cysts always require resection because of their high complication rate (66%) after conservative treatment.
  • [MeSH-minor] Adult. Age Factors. Child. Female. Humans. Incidence. Male. Mediastinoscopy. Mediastinum / pathology. Neoplasm Staging. Prognosis. Radiography. Thoracoscopy. Thoracotomy

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  • (PMID = 18058077.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
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15. Koizumi K, Haraguchi S, Mikami I, Kubokura H, Okada D, Yamagishi S, Kinoshita H, Enomoto Y, Shimizu K, Maeda M: Video-assisted thoracic surgery for Ewing's sarcoma of the mediastinum in a 3-year-old girl. Ann Thorac Cardiovasc Surg; 2005 Apr;11(2):117-20
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  • [Title] Video-assisted thoracic surgery for Ewing's sarcoma of the mediastinum in a 3-year-old girl.
  • We report of the experience of video-assisted thoracic surgery (VATS) for a Ewing's sarcoma at the posterior mediastinum in a 3 year old girl.
  • The patient developed common cold like symptoms and developed rapid lower limb paraplegia.
  • A chest computed tomography (CT) showed a solid mass adjacent to the vertebrae.
  • As the tumor reduced after induction chemotherapy, with improvement of paraplegia, the patient underwent thoracoscopic examination followed by complete removal of the tumor by VATS.
  • Five years has passed after operation without tumor recurrence.
  • VATS could be an option as combined therapy for Ewing's sarcoma when well controlled and localized under induction therapy.
  • [MeSH-minor] Child, Preschool. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Spinal Cord Compression / etiology. Tomography, X-Ray Computed

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  • (PMID = 15900244.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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16. Hayakawa H, Obama K, Tara M: [Intradural recurrence of multiple myeloma during the hematological complete remission]. Rinsho Ketsueki; 2002 Nov;43(11):1009-13
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  • Pretreatment examination revealed IgG-lambda type M-protein, Bence-Jones protein and the posterior mediastinum tumor.
  • As a result of VAD, MP, interferon and radiation therapy, he had a hematological complete remission.
  • After 21 months, he developed intradural relapse at cauda equina and cerebrum.
  • Many plasma cells and IgG-lambda type M-protein were detected in the cerebrospinal fluid.
  • The myeloma cells might have infiltrated the intradural space at diagnosis and expanded in the central nervous system despite chemotherapy.
  • Because reported cases with cerebral and meningeal myeloma are increasing according to the recent advance of treatment, we must pay attention to the meningeal myeloma.

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  • (PMID = 12508488.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 14
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17. Brook I: Microbiology and management of peritonsillar, retropharyngeal, and parapharyngeal abscesses. J Oral Maxillofac Surg; 2004 Dec;62(12):1545-50
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  • This review describes the microbiology, diagnosis, and management of peritonsillar, retropharyngeal, and parapharyngeal abscesses in children.
  • Systemic antimicrobial therapy should be given in large doses whenever the diagnosis is made.
  • However, when pus is formed, antimicrobial therapy is effective only in conjunction with adequate surgical drainage.
  • Other complications are extension of infection laterally to the side of the neck or dissection into the posterior mediastinum through facial planes and the prevertebral space.
  • Death can occur from aspiration, airway obstruction, erosion into major blood vessels, or extension to the mediastinum.
  • [MeSH-major] Abscess / microbiology. Abscess / prevention & control. Pharyngeal Diseases / drug therapy. Pharyngeal Diseases / microbiology. Pharynx / physiopathology
  • [MeSH-minor] Adolescent. Adult. Airway Obstruction / etiology. Airway Obstruction / therapy. Anti-Bacterial Agents / therapeutic use. Child. Child, Preschool. Humans. Peritonsillar Abscess / diagnosis. Peritonsillar Abscess / drug therapy. Peritonsillar Abscess / microbiology. Recurrence. Retropharyngeal Abscess / diagnosis. Retropharyngeal Abscess / drug therapy. Retropharyngeal Abscess / microbiology

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  • (PMID = 15573356.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Number-of-references] 38
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18. Sawicz-Birkowska K, Czernik J, Chrzan R, Kołodziej J: [Mediastinal tumors in children]. Pol Merkur Lekarski; 2002 Oct;13(76):305-7

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  • There were 39 lesions in the anterior, 21 in the medial and 49 in the posterior mediastinum.
  • Combined treatment (radio-, chemotherapy and surgical treatment) was introduced to deal with neurogenic tumours in children.
  • Comparing two periods of time (1970-85 v 1986-2000) no significant differences were found in the prevalence of any kind of mediastinal tumours.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Mediastinoscopy. Poland / epidemiology. Prevalence. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 12557437.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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19. La Quaglia MP, Kushner BH, Su W, Heller G, Kramer K, Abramson S, Rosen N, Wolden S, Cheung NK: The impact of gross total resection on local control and survival in high-risk neuroblastoma. J Pediatr Surg; 2004 Mar;39(3):412-7; discussion 412-7
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  • BACKGROUND/PURPOSE: Gross total resection of the primary tumor in treatment of high-risk neuroblastoma remains controversial.
  • Furthermore, there are few reports of the effect of primary tumor resection on local control as opposed to overall survival.
  • The authors reviewed their institutional experience to assess the effect of primary tumor resection on local control and overall survival.
  • The primary site was the adrenal gland in 74%, the central abdominal compartment in 13%, the posterior mediastinum in 7%, and other sites in 6%.
  • CONCLUSIONS: Our data indicate that local control and overall survival rate are correlated with gross total resection of the primary tumor in high-risk neuroblastoma.
  • [MeSH-major] Abdominal Neoplasms / drug therapy. Abdominal Neoplasms / surgery. Adrenal Gland Neoplasms / drug therapy. Adrenal Gland Neoplasms / surgery. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / surgery. Neuroblastoma / drug therapy. Neuroblastoma / surgery
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Disease Progression. Humans. Infant. Iodine Radioisotopes. Neoplasm Staging. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate

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  • (PMID = 15017562.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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20. Stein HJ, Feith M, Siewert JR: Cancer of the esophagogastric junction. Surg Oncol; 2000 Jul;9(1):35-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer of the esophagogastric junction.
  • Epidemiological, clinical and pathological data support a sub-classification of adenocarcinomas arising in the vicinity of the esophagogastric junction (AEG) into adenocarcinoma of the distal esophagus (Type I), true carcinoma of the cardia (Type II) and subcardial carcinoma (Type III).
  • While most, if not all, adenocarcinomas of the distal esophagus arise from areas with specialized intestinal metaplasia, which develop as a consequence of chronic gastroesophageal reflux, the etiology and pathogenesis of true carcinoma of the gastric cardia and subcardial gastric cancer is not clear at present.
  • Irrespective of the etiology, a complete removal of the primary tumor and its lymphatic drainage has to be the primary goal of any surgical approach to adenocarcinoma of the esophagogastric junction.
  • Our experience in the management of more than 1000 such patients during the past 18 years suggests that an individualized therapeutic strategy oriented by tumor type and stage results in survival rates superior to those reported with a more indiscriminate approach.
  • This individualized strategy prescribes a transmediastinal esophagectomy with lymphadenectomy in the lower posterior mediastinum and along the celiac axis for Type I tumors, extended total gastrectomy with transhiatal resection of the distal esophagus and D2 lymphadenectomy for Type II and Type III tumors, a limited resection of the esophagogastric junction and distal esophagus with interposition of a pedicled jejunal segment for uT1N0 tumors, and neoadjuvant chemotherapy followed by resection for uT3/T4 tumors.
  • Extensive preoperative staging is essential to allow correct selection of the appropriate therapeutic strategy using this tailored approach.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / therapy. Esophagogastric Junction. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy
  • [MeSH-minor] Algorithms. Combined Modality Therapy. Decision Trees. Esophagectomy. Gastrectomy. Gastroesophageal Reflux / complications. Humans. Incidence. Lymph Node Excision. Neoplasm Staging. Preoperative Care. Prevalence. Splenectomy. Survival Analysis. Treatment Outcome

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  • (PMID = 11525305.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 36
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21. Kato K, Nagaoka Y, Kobayashi T, Takata K, Miura Y, Amagasa S: [Tension pneumothorax manifested after extubation in a patient who underwent total gastrectomy]. Masui; 2003 Jul;52(7):777-9
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  • [Title] [Tension pneumothorax manifested after extubation in a patient who underwent total gastrectomy].
  • A patient developed tension pneumothorax immediately after extubation.
  • The posterior mediastinum drainage tube was placed near the site of esophago-jejunum anastomosis.
  • Surgeons reported that they might have injured left diaphragmatic pleura during the procedure.
  • Diagnosis of tension pneumothorax was made from emergency chest X-ray.
  • Air leakage decreased significantly when the mediastinum drainage tube was tentatively occluded.

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  • (PMID = 12910984.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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22. Boutros J, Bond M, Beaudry P, Blair GK, Skarsgard ED: Case selection in minimally invasive surgical treatment of neuroblastoma. Pediatr Surg Int; 2008 Oct;24(10):1177-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case selection in minimally invasive surgical treatment of neuroblastoma.
  • PURPOSE: The experience with minimally invasive surgery (MIS) in the treatment of neuroblastoma (NB) is anecdotal.
  • Six of the eight (75%) tumors were adrenal in origin and the remainder were located in the posterior mediastinum.
  • One stage 4 tumor was N-myc amplified.
  • All stage 4 patients experienced a >50% tumor volume cytoreduction in response to preoperative chemotherapy.
  • All MIS resections were performed without need for blood transfusion, or conversion to open procedure, and there were no perioperative complications.
  • CONCLUSIONS: With appropriate preoperative case selection based on anatomic features, MIS tumor resection in patients with NB can be performed safely and effectively.
  • [MeSH-minor] Adolescent. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / surgery. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Male. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / surgery. Neoadjuvant Therapy. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery. Retrospective Studies

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  • (PMID = 18716783.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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23. Aujesky R, Neoral C, Kral V, Bohanes T, Vrba R, Vomackova K: Video-assisted laparoscopic resection of the esophagus for carcinoma after neoadjuvant therapy. Hepatogastroenterology; 2009 Jul-Aug;56(93):1035-8
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  • [Title] Video-assisted laparoscopic resection of the esophagus for carcinoma after neoadjuvant therapy.
  • METHODOLOGY: Between 2000-2006 forty-three patients with esophageal cancer underwent video-laparoscopic transhiatal esophagectomy.
  • In all patients passage was renewed by esophagogastroplasty, constructed by placing the neoesophagus in the posterior mediastinum, anastomosis with the cervical esophagus from a laparotomy.
  • Prior to the operation, 27 patients underwent neoadjuvant radio-chemotherapy.
  • Chemotherapy consisted of 5 fluorouracil and cisplatinum, and radiotherapy with a total dose of 50 Gy.
  • Right-sided pneumothorax was seen in 27 patients, in six cases postoperative manifestation of left vocal chord paresis due to damage to the recurrent laryngeal nerve was observed, in 2 patients a fistula developed in the cervical anastomosis, which in all cases healed spontaneously.
  • The operation time ranged between 225-370 minutes, the average time being 256 minutes.
  • In tumors localized in the lower portion of the esophagus, it completely replaces the transhiatal "blind" approach according to Orringer and, in comparison, eliminates operative hemorrhagic complications, which are more frequent in "blind" extirpations, especially in patients after neoadjuvant therapy.
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Female. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoadjuvant Therapy. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 19760936.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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24. Lonergan GJ, Schwab CM, Suarez ES, Carlson CL: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics; 2002 Jul-Aug;22(4):911-34
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  • They arise wherever sympathetic tissue exists and may be seen in the neck, posterior mediastinum, adrenal gland, retroperitoneum, and pelvis.
  • The most benign tumor is the ganglioneuroma, which is composed of gangliocytes and mature stroma.
  • Ganglioneuroblastoma is composed of both mature gangliocytes and immature neuroblasts and has intermediate malignant potential.
  • Neuroblastoma is the most immature, undifferentiated, and malignant tumor of the three.
  • Features such as DNA content, tumor proto-oncogenes, and catecholamine synthesis influence prognosis, and their presence or absence aids in categorizing patients as high, intermediate, or low risk.
  • Treatment consists of surgery and, usually, chemotherapy.
  • Despite recent advances in treatment, including bone marrow transplantation, neuroblastoma remains a relatively lethal tumor, accounting for 10% of pediatric cancers but 15% of cancer deaths in children.
  • [MeSH-minor] Ganglioneuroblastoma / pathology. Ganglioneuroblastoma / radiography. Humans. Magnetic Resonance Imaging. Neoplasm Staging. Prognosis. Risk Factors. Tomography, X-Ray Computed

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  • [Copyright] Copyright RSNA, 2002
  • (PMID = 12110723.001).
  • [ISSN] 0271-5333
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 123
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25. Caudry M, Ratoanina JL, Escarmant P, Maire JP: [Target volume in radiotherapy of gastric adenocarcinoma]. Cancer Radiother; 2001 Oct;5(5):523-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Les volumes-cibles de la radiothérapie des adénocarcinomes gastriques.
  • A GTV should be considered in preoperative or exclusive radiation therapy.
  • a) A "tumor bed" volume.
  • Parietal infiltration may extend beyond macroscopic limits of the tumor, especially in "linitis plastica".
  • Therefore this volume will include: the tumor and the remaining stomach or their "bed of resection", a part of the transverse colon, the duodenum, the pancreas and the truncus of the portal vein.
  • (1) contiguous microscopic extension from deeply invasive T3 and T4 tumors, that remain amenable to local sterilization with doses of 45-50 Gy, delivered in a CTV including the peritoneal cavity at the level of the gastric bed, and under the parietal incision;.
  • (2) true "peritoneal carcinomatosis", with widespread seeds, where chemotherapy (systemic or intraperitoneal) is more appropriate.
  • In distal and proximal tumors, involvement of resection margins is of poor prognosis--a radiation boost must be delivered at this level.
  • The CTV in tumors of the cardia should encompass the lower part of the thoracic esophagus and the corresponding posterior mediastinum.
  • In tumors invading the distal esophagus, a more complete coverage of mediastinal lymph nodes should be considered, especially in patients in good general condition.
  • In contrast, for distal tumors, the hepatic pedicle and the hepatoduodenal ligament should be included whereas the splenic area could be spared.
  • CONCLUSION: Planning the treatment of gastric cancer remains difficult; target volumes must be customized by experienced radiation oncologists according to tumoral and clinical situation.
  • [MeSH-minor] Dose Fractionation. Humans. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm, Residual

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  • (PMID = 11715304.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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