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Items 1 to 25 of about 25
1. Lee CC, Chen WM, Yen CC, Wu HD, Chen TH: Malignant lymphoma in an atomic-bomb survivor. J Chin Med Assoc; 2009 Jul;72(7):388-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant lymphoma in an atomic-bomb survivor.
  • Spinal malignant lymphoma among these survivors is rare in established studies from Japan or the United States.
  • Both follicular lymphoma over the right elbow region and vertebral malignant lymphoma were found when she turned 81 years old.
  • However, thoracolumbar spine magnetic resonance imaging showed multiple infiltrative soft tissue masses involving vertebral bodies at the T10-11 level.
  • Computed tomography-guided biopsy further showed lymphocyte infiltration.
  • Fortunately, the neurological deficit was improved after chemotherapy.
  • The diagnosis of malignant lymphoma in atomic bomb survivors should be more careful and aggressive, even when their bone scan results show negative findings.
  • [MeSH-major] Epidural Neoplasms / etiology. Lymphoma, Follicular / etiology. Neoplasms, Radiation-Induced / etiology. Nuclear Warfare. Survivors

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  • (PMID = 19581148.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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2. Fujisawa H, Takagane H, Shimosegawa K, Sakuma T: [Primary malignant lymphoma of the ureter: a case report]. Hinyokika Kiyo; 2004 Oct;50(10):721-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary malignant lymphoma of the ureter: a case report].
  • Computed tomography and retrograde pyelography revealed a soft tissue mass in the middle portion of the right ureter.
  • Under the diagnosis of right ureteral cancer, we performed right total nephro-ureterectomy, partial cystectomy.
  • The histopathological examination showed non-Hodgkin lymphoma (large B-cell type) of the ureter.
  • Our diagnosis was Clinical Stage IE of the Ann Arbor Classification.
  • The patient received only the first course of systemic chemotherapy (THP-cop), because he suffered severe thrombocytopenia in the course of the chemotherapy.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Ureteral Neoplasms / diagnosis

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  • (PMID = 15575226.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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3. Yamauchi K, Yasuda M: Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature. Cancer; 2002 Mar 15;94(6):1739-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature.
  • BACKGROUND: The purpose of this study was to reveal the clinical characteristics of nonleukemic granulocytic sarcoma (GS) and an association between the therapeutic regimens and the nonleukemic period.
  • These patients were divided into 3 groups by therapeutic regimens; Group I included 12 patients who received only biopsy or surgical resection of the tumor, Group II was 20 patients who received local irradiation for the tumor, and Group III consisted of 42 patients who received systemic chemotherapy.
  • In Group III, the period in the patients who were treated with chemotherapy given to ANLL was compared with that in the patients who received chemotherapy used for malignant lymphoproliferative disorders (MLPDs).
  • RESULTS: Thirty-five patients (47%) initially were misdiagnosed, and the disease was most often malignant lymphoma.
  • Preferential sites of GS were the small intestine, mediastinum, epidural site, uterus, and ovary, which often are difficult for the detection and diagnosis in addition to the skin and lymph nodes known commonly.
  • The nonleukemic period after the diagnosis of GS was significantly longer in Group III than in the other groups (median, 12 months in Group III vs. 3 and 6 months in Groups I and II, respectively).
  • The aggressive chemotherapy given to ANLL led to a longer nonleukemic period than the chemotherapy used for MLPDs.
  • CONCLUSIONS: To reduce the risk of subsequent ANLL in patients with nonleukemic GS, it is important that accurate histologic diagnosis is established initially for GS and that all isolated cases of GS, even those that appear to be cured by resection or irradiation of the tumor, are treated with intensive chemotherapy similar to that used to treat ANLL during the nonleukemic period as soon as possible.
  • [MeSH-major] Leukemia, Myeloid, Acute / etiology. Sarcoma, Myeloid / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Humans. Lymphoma / diagnosis. Male. Middle Aged. Survival Analysis

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  • [Copyright] Copyright 2002 American Cancer Society.
  • (PMID = 11920536.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 59
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4. Hirai S, Hamanaka Y, Mitsui N, Morifuji K, Sutoh M: Primary malignant lymphoma arising in the pleura without preceding long-standing pyothorax. Ann Thorac Cardiovasc Surg; 2004 Oct;10(5):297-300
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  • [Title] Primary malignant lymphoma arising in the pleura without preceding long-standing pyothorax.
  • We report a very rare case of primary malignant lymphoma arising in the pleura with no history of persistent pyothorax.
  • Immunohistochemical examination of the pleural tumor showed that the histology was marginal zone B-cell malignant lymphoma.
  • We considered that this tumor had originated from the soft tissue in the chest wall based on radiographical and surgical findings.
  • As diagnosis and treatment of pleural malignant lymphoma seems to have been difficult in most cases reported in the literature, it is thought that early active and accurate biopsy with large-bore needles, or, if possible, surgical incision for early diagnosis and aggressive surgery to achieve complete resection combined with radiation therapy and/or chemotherapy would be very important for a good prognosis.
  • [MeSH-major] Lymphoma, B-Cell / complications. Lymphoma, B-Cell / diagnosis. Pleural Neoplasms / complications. Pleural Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Needle. Carcinoembryonic Antigen / blood. Combined Modality Therapy. Diagnosis, Differential. Dyspnea / etiology. Empyema, Pleural / etiology. Humans. Immunohistochemistry. Japan / epidemiology. Male. Prognosis. Rare Diseases. Thoracotomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15563266.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
  • [Number-of-references] 12
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5. Strunk T, Bastian PJ, Ellinger J, Biermann K, Müller SC: [Aggressive course of a malignant alveolar soft tissue sarcoma]. Urologe A; 2007 Oct;46(10):1422-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Aggressive course of a malignant alveolar soft tissue sarcoma].
  • Alveolar soft part sarcoma is a rare soft tissue tumor.
  • Publications concerning this sarcoma subform are rare and the best therapeutic procedure is not yet clear.
  • Surgical excision, radiation and chemotherapy are performed, whereas complete surgical excision achieves the best results in long-term follow-up.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Sarcoma, Alveolar Soft Part / diagnosis
  • [MeSH-minor] Aged. Capillaries / pathology. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Lymphoma, Non-Hodgkin / pathology. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Radiotherapy, Adjuvant. Retreatment. Testicular Neoplasms / pathology. Tomography, X-Ray Computed

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  • [Cites] J Natl Cancer Inst. 2000 Feb 2;92 (3):205-16 [10655437.001]
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  • (PMID = 17641862.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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6. Mealey BL, Tunder GS, Pemble CW 3rd: Primary extranodal malignant lymphoma affecting the periodontium. J Periodontol; 2002 Aug;73(8):937-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary extranodal malignant lymphoma affecting the periodontium.
  • BACKGROUND: Non-Hodgkin's lymphoma may arise in extranodal tissues within the head and neck region.
  • Due to their malignant nature, rapid identification, diagnosis, and treatment of non-Hodgkin's lymphomas are essential to patient survival.
  • METHODS: An unusual case of primary extranodal non-Hodgkin's lymphoma is described.
  • Upon excision, the tissue was submitted for microscopic examination, with the expectation that the lesion would be benign and excision would constitute the entirety of treatment.
  • However, a diagnosis of primary extranodal large B-cell lymphoma was returned.
  • Chemotherapy and radiation therapy were performed.
  • The patient has remained healthy, without recurrence of lymphoma for 3 years.
  • CONCLUSIONS: This case reinforces the importance of submitting excised tissues for microscopic examination even when the lesion appears totally benign.
  • In addition, it highlights the need for complete excision of suspected lesions, with generous borders of normal tissue.
  • With current periodontal plastic surgical techniques, most defects remaining after soft tissue biopsy can be managed with good esthetic results.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Diagnosis, Differential. Disease-Free Survival. Follow-Up Studies. Humans. Male. Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Radiotherapy, Adjuvant

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  • (PMID = 12211504.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Dürr HR, Müller PE, Hiller E, Maier M, Baur A, Jansson V, Refior HJ: Malignant lymphoma of bone. Arch Orthop Trauma Surg; 2002 Feb;122(1):10-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant lymphoma of bone.
  • Malignant lymphoma of bone is rare.
  • In many cases, its diagnosis is delayed because of unspecific clinical signs and equivocal radiographs.
  • Therapy in general is multimodal, including surgery and radio- and chemotherapy.
  • Our objective was to demonstrate the clinical and radiological aspects of the lesion to optimize diagnostic approaches and to evaluate treatment and prognostic factors.
  • Thirty-six patients with malignant lymphoma of bone who were surgically treated over a 15-year-period were retrospectively reviewed.
  • Seventeen of them showed a singular bone non-Hodgkin's lymphoma (NHL) which was classified as primary lymphoma of the bone (PLB).
  • Surgical treatment was indicated for diagnostic reasons or complications due to the disease.
  • Radiation and chemotherapy were part of the oncological treatment.
  • The main symptom in malignant bone lymphoma in 33 patients was pain, with an average duration of 8 months.
  • In the secondary cases, bone involvement appeared on average 57 months after the initial diagnosis.
  • Soft-tissue involvement was seen in 71% of cases (PLB 80%, dNHL 73%, HD 40%) and was the primary diagnostic sign associated with this disease.
  • The clinical appearance is nonspecific, and the delay between the onset of symptoms and diagnosis is often long.
  • One of the major radiologic signs is the existence of a soft-tissue tumor surrounding the bone with little or no bone involvement on plain films.
  • Treatment generally is conservative, based on the stage of the disease.
  • Local radiation with or without systemic chemotherapy should be used.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / therapy. Hodgkin Disease / pathology. Lymphoma, Non-Hodgkin / pathology. Lymphoma, Non-Hodgkin / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Orthopedic Procedures / methods. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 11995873.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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8. Yasumoto M, Taura S, Shibuya H, Honda M: Primary malignant lymphoma of the maxillary sinus: CT and MRI. Neuroradiology; 2000 Apr;42(4):285-9
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  • [Title] Primary malignant lymphoma of the maxillary sinus: CT and MRI.
  • We reviewed the CT and MRI of seven patients with primary malignant lymphoma of the maxillary sinus to find if there are characteristic imaging findings suggestive of the disease.
  • In the remaining five, the tumours were an expansile mass 4-6 cm in diameter at the time of detection.
  • Periantral soft-tissue infiltration was always present, even when tumour appeared as slight mucosal thickening.
  • Permeative and lytic bone destruction accompanied most cases of periantral soft-tissue infiltration; mixed destruction and sclerosis was also observed.
  • Mucosal thickening with periantral soft-tissue infiltration may suggest malignant lymphoma of the maxillary sinus in its early form.
  • Various types of bone change may accompany the periantral soft-tissue infiltration.
  • [MeSH-major] Lymphoma / diagnosis. Maxillary Sinus Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 10872174.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] GERMANY
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9. Orzechowska-Wylegała B, Kajor M, Mazur M, Wodołazski A, Malara P, Drugacz J: [Malignant lymphoma or inflammation? Diagnostic and treatment difficulties--2 cases report]. Pol Merkur Lekarski; 2006 Apr;20(118):433-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant lymphoma or inflammation? Diagnostic and treatment difficulties--2 cases report].
  • Soft and hard tissue in the oral cavity can be the first coexisting place of systemic diseases manifestation.
  • The aim of this study was to report the diagnostic and treatment difficulties in two patients with malignant lymphomas.
  • The first case was a 66-year-old woman who had undergone surgery procedures connected with radiotherapy and chemotherapy because of malignant lymphoma in nasal cavity in 2001 year.
  • In 2002 she was treated in our department after finding tumor in oral cavity, also diagnosed as malignant lymphoma.
  • On the next year he underwent an operation of removal cervical lymp nodes because of malignant lymphoma.
  • In 2004 year he underwent surgery on account of maxillary tumor suspected by malignant lymphoma, which was diagnosed as inflammation.
  • Conclusions. In differentiation tumors of head and neck one should take an account of lymphoma malignant.
  • The similar clinic and radiological symptoms and laboratory results of malignant lymphomas and inflammations of head and neck can cause the late diagnosis and aggravate the prognosis of this severe disease.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Inflammation / diagnosis. Lymphoma / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 16886569.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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10. Adamson DC, Cummings TJ, Friedman AH: Malignant peripheral nerve sheath tumor of the spine after radiation therapy for Hodgkin's lymphoma. Clin Neuropathol; 2004 Sep-Oct;23(5):245-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant peripheral nerve sheath tumor of the spine after radiation therapy for Hodgkin's lymphoma.
  • We report the development of a malignant peripheral nerve sheath tumor (MPNST) in 2 patients after irradiation for Hodgkin's lymphoma.
  • Clinicians should be aware of this uncommon, but important fatal complication of radiation therapy.
  • The first case is a 37-year-old man who was diagnosed with nodular sclerosing (NS) Hodgkin's lymphoma and underwent successful mantle radiation.
  • The second case is a 30-year-old female diagnosed with NS Hodgkin's lymphoma.
  • She did well with extensive radiotherapy until 5 years later when she developed severe right arm and chest pain secondary to recurrent lymphoma.
  • After aggressive radio- and chemotherapy, she presented to the neurosurgery service with a right Horner's syndrome, right C6 radiculopathy, and weakness of her right triceps and wrist extensors.
  • Two years after radiation therapy for his Hodgkin's lymphoma, the first patient underwent a C6 laminectomy at an outside institution for resection of a benign neurofibroma.
  • We present 2 case reports of patients who developed neurofibrosarcomatous tumors with malignant transformation after undergoing radiation therapy for Hodgkin's lymphoma.
  • Numerous cases of soft tissue tumors have been described to arise in areas of prior radiation therapy; however, there have been rare reports of de novo MPNST after radiation therapy, especially in the setting of Hodgkin's lymphoma.
  • Postirradiation MPNST should be considered in the differential diagnosis of a painful, enlarging mass in a previously irradiated area.
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male


11. Belaabidia B, Sellami S, Hamdaoui R, Essadki B: [Primary malignant non-Hodgkin skeletal muscle lymphoma: a case report]. Rev Chir Orthop Reparatrice Appar Mot; 2002 Sep;88(5):518-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary malignant non-Hodgkin skeletal muscle lymphoma: a case report].
  • BACKGROUND: Malignant non-Hodgkin lymphoma (NHL) is rarely encountered in soft tissue.
  • The differential diagnosis with other soft tissue tumors, particularly sarcoma, is difficult.
  • At computed tomography, the mass measured 17x14x7 cm and was situated in the biceps femoris.
  • Tumor biopsy demonstrated diffuse malignant small B-cell lymphomatous-plasma cell proliferation.
  • The diagnosis was primary NHL of the biceps femoris.
  • Wide resection was followed by chemotherapy.
  • Magnetic resonance imaging and computed tomography visualize characteristic features.
  • Diagnosis is formally established by pathology.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Muscle Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Thigh. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 12399719.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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12. Kowalczyk J, Nurzyńska-Flak J, Armata J, Bogusławska-Jaworska J, Rokicka-Milewska R, Sońta-Jakimczyk D, Balwierz W, Chybicka A, Kaczmarek-Kanold M, Wachowiak J, Matysiak M, Pawelec K: Incidence and clinical characteristics of second malignant neoplasms in children: a multicenter study of a polish pediatric leukemia/lymphoma group. Med Sci Monit; 2004 Mar;10(3):CR117-22
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  • [Title] Incidence and clinical characteristics of second malignant neoplasms in children: a multicenter study of a polish pediatric leukemia/lymphoma group.
  • BACKGROUND: The development of second malignant neoplasms (SMNs) in patients receiving chemotherapy and radiation therapy for primary cancers is one of the limitations to the quality and length of survival.
  • The present study was undertaken to examine various characteristics of children who developed SMNs following successful therapy for primary leukemia or Hodgkin's disease (HD).
  • RESULTS: Of the 3252 patients diagnosed as having acute leukemia during this period, 16 developed SMNs (estimated frequency 0.49%).
  • SMNs developed in 20 of the 849 children treated for HD (2.36%).
  • The most frequent SMNs were soft tissue sarcoma and thyroid carcinomas, mainly following Hodgkin's disease.
  • The interval from the end of initial treatment to diagnosis of an SMN ranged from 2 years 7 months to 17 years 6 months, with a median of 7 yrs 4 mo. for acute lymphoblastic leukemia (ALL) patients and 10 years for children with HD.
  • [MeSH-major] Hodgkin Disease / pathology. Hodgkin Disease / therapy. Leukemia / pathology. Leukemia / therapy. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / epidemiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Incidence. Infant. Male. Sarcoma / secondary. Soft Tissue Neoplasms / secondary. Thyroid Neoplasms / secondary. Time Factors

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  • (PMID = 14976453.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
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13. Beden U, Sonmez B, Kandemir B, Erkan D: Bilateral simultaneous primary orbital lymphoma presenting with unilateral enophthalmos. Ophthal Plast Reconstr Surg; 2008 Mar-Apr;24(2):145-7
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  • [Title] Bilateral simultaneous primary orbital lymphoma presenting with unilateral enophthalmos.
  • MRI revealed bilateral hypointense orbital soft-tissue masses.
  • Pathologic evaluation of incisional biopsy specimens revealed malignant tissue composed of diffuse, mitotically active, atypical large lymphoid cells positive for CD-20 with immunohistochemical staining, confirming the diagnosis of malignant diffuse large B-cell lymphoma.
  • After R-CHOP chemotherapy (Rituximab 375 mg/m2 intravenously, Cyclophosphamide 750 mg/m2 intravenously, Doxorubicin 50 mg/m2 intravenously, Vincristine 1.4 mg/m2 intravenously, Prednisolone 100 mg orally), Hertel measurements were 9.0 mm in the right eye and 11.0 mm in the left eye.
  • Although rare, non-Hodgkin lymphoma may present bilaterally as primary orbital lesions and can unexpectedly cause enophthalmos instead of proptosis.
  • [MeSH-major] Enophthalmos / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Orbital Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Entropion / etiology. Female. Functional Laterality. Humans. Magnetic Resonance Imaging. Prednisone / therapeutic use. Rituximab. Vincristine / therapeutic use

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  • (PMID = 18356723.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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14. Kurosawa H, Matsunaga T, Shimaoka H, Sato Y, Kuwashima S, Sugita K, Hagane K, Eguchi M: Burkitt lymphoma associated with large gastric folds, pancreatic involvement, and biliary tract obstruction. J Pediatr Hematol Oncol; 2002 May;24(4):310-2
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  • [Title] Burkitt lymphoma associated with large gastric folds, pancreatic involvement, and biliary tract obstruction.
  • Large gastric folds in adults are seen in many benign and malignant conditions, but they are rare in children with malignant diseases such as non-Hodgkin lymphoma.
  • The authors report a patient with non-Hodgkin lymphoma who had large gastric folds and jaundice as the initial symptoms.
  • Magnetic resonance imaging showed a typical diffuse infiltrating type of pancreatic lymphoma.
  • Because complete bilateral lower limb paralysis developed as a result of the epidural soft tissue mass, laminectomy and tumor resection were performed and a diagnosis of disseminated Burkitt lymphoma was established.
  • After completing 6 months of chemotherapy, the patient has been disease-free without neurologic complications for 2.5 years.
  • [MeSH-major] Burkitt Lymphoma / diagnosis. Cholestasis / diagnosis. Gastric Mucosa / pathology. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 11972102.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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15. Castellucci P, Zinzani P, Nanni C, Farsad M, Moretti A, Alinari L, Battista G, Pettinato C, Marengo M, Boschi S, Canini R, Baccarani M, Monetti N, Fanti S: 18F-FDG PET early after radiotherapy in lymphoma patients. Cancer Biother Radiopharm; 2004 Oct;19(5):606-12
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  • [Title] 18F-FDG PET early after radiotherapy in lymphoma patients.
  • OBJECTIVE: The aim of this study was to evaluate the rate of postactinic inflammatory alterations that could lead to false-positive results in FDG-PET images, in a group of lymphoma patients studied with positron emission tomography (PET) early after the end of radiation therapy.
  • MATERIALS AND METHODS: Sixteen (16) consecutive patients were referred to our center for malignant lymphoma; 14 of 16 patients had a mediastinal bulky mass at diagnosis.
  • Each patient underwent chemotherapy and then radiotherapy (RT): for clinical reasons, shortly after RT (range, 25-56 days; mean, 38.7 days) a FDG PET scan was required to evaluate the effect of therapy.
  • RESULTS: Despite a relatively short time after RT, there was no pathological tracer uptake in 13 of 16 patients.
  • In 3 cases, a mild increase in FDG uptake was observed, but no findings which would lead to a false-positive diagnosis.
  • In 2 of 3 cases, postactinic pneumopathy was diagnosed (PET scan performed 51 and 52 days after RT); while in 1 patient, soft-tissue inflammation was present (PET scan performed 42 days after RT).
  • CONCLUSION: Our data indicates that the rate of postactinic PET inflammatory alterations in lymphoma patients is not very high and appear to be not strictly linked to the elapsed time since the end of RT treatment.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacology. Lymphoma / drug therapy. Lymphoma / radiotherapy. Positron-Emission Tomography / methods. Radiopharmaceuticals / pharmacology
  • [MeSH-minor] Adult. False Positive Reactions. Female. Hodgkin Disease / radiotherapy. Humans. Inflammation. Lymphoma, Non-Hodgkin / radiotherapy. Male. Middle Aged. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15650453.001).
  • [ISSN] 1084-9785
  • [Journal-full-title] Cancer biotherapy & radiopharmaceuticals
  • [ISO-abbreviation] Cancer Biother. Radiopharm.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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16. Koukourakis G, Kouloulias V: Lymphoma of the testis as primary location: tumour review. Clin Transl Oncol; 2010 May;12(5):321-5
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  • [Title] Lymphoma of the testis as primary location: tumour review.
  • Non-Hodgkin's lymphoma as a primary testicular neoplasm accounts approximately 9% of all testicular malignant tumours and about 1-2% of all non-Hodgkin's lymphoma.
  • This neoplasm is the most common malignant tumour of the testis in the elderly.
  • The most common histotype in primary forms is the diffuse large B-cell lymphoma, whereas more aggressive histologies such as Burkitt's lymphoma are principal founded in cases of secondary involvement of the testis.
  • Despite the fact that responses to doxorubicin- containing chemotherapy, especially in early stages, show good results, relapses are often seen, and the prognosis of this tumour is very poor.
  • Testicular lymphoma often disseminates to other extranodal organs, such as contralateral testis, central nervous system (CNS), lung, pleura, Waldeyer's ring and soft tissue.
  • For patients with limited disease, the recommended first-line treatment is orchiectomy followed by rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) combination chemotherapy, with central nervous system (CNS) prophylaxis and prophylactic irradiation of the contralateral testis.
  • In more advanced or relapsed disease, management should follow the worldwide recommendations for nodal diffuse large B-cell lymphoma (DLBCL).
  • [MeSH-major] Lymphoma / diagnosis. Lymphoma / therapy. Testicular Neoplasms / diagnosis. Testicular Neoplasms / therapy

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  • (PMID = 20466616.001).
  • [ISSN] 1699-3055
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 44
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17. Chastagner P: [Malignant extraconal tumors of the orbit in childhood]. Neurochirurgie; 2010 Apr-Jun;56(2-3):281-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant extraconal tumors of the orbit in childhood].
  • Malignant extraconal orbital tumors are very rare during childhood and must be referred as soon as possible to a highly specialized center to be managed by a multidisciplinary team.
  • Both diagnosis and treatment must be undertaken as soon as possible.
  • The course of these malignant tumors can be acute and can jeopardize the function of the eye or be life-threatening, especially in the event of metastatic locations.
  • Sometimes diagnosis should be clear with the association of an orbital tumor and deterioration of the general health status favoring metastatic disease.
  • Today both CT and MRI are highly valuable in assessing the diagnosis and starting the management of these tumors.
  • Biopsy is mandatory to confirm the diagnosis.
  • Among the primitive tumors, soft tissue sarcomas, especially rhabdomyosarcomas, are the most frequent.
  • The diagnosis is suggested when the onset of the disease is acute and the course is rapid.
  • Most respond to neoadjuvant chemotherapy.
  • In the event of a residual tumor, local treatment is indicated so that surgery and/or radiotherapy are used as second-line treatment.
  • It can be satisfactory (Langerhans' cell histiocytosis, lymphoma, meningioma, infantile fibrosarcoma) or poor (metastatic tumor, rhabdoid tumor).
  • [MeSH-minor] Child. Child, Preschool. Combined Modality Therapy. Exophthalmos / etiology. France. Humans. Incidence. Infant. Male. Neoplasm Metastasis. Prognosis. Rhabdomyosarcoma / epidemiology. Rhabdomyosarcoma / surgery. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20303550.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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18. Nishiyama N, Nakatani S, Inoue K, Katoh T, Kinoshita H: Primary lymphoma of bone originating in a rib. Jpn J Thorac Cardiovasc Surg; 2000 Mar;48(3):180-3
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  • [Title] Primary lymphoma of bone originating in a rib.
  • Malignant lymphoma originating in the bone is rare and is now recognized as being an independent clinicopathologic entity known as primary lymphoma of bone.
  • Chest X-ray and computed tomogram revealed osteolysis and a surrounding soft tissue mass in the sixth right rib.
  • A diagnosis of diffuse, medium-sized non-Hodgkin's lymphoma, B-cell type was made.
  • Unfortunately, postoperative treatment with radiation therapy and chemotherapy was ultimately unsuccessful, and a local recurrence and metastatic lesions appeared in the stomach and para-aortic abdominal lymph nodes 7 months after the first symptom appeared.
  • Surgery was chosen as the initial therapy as it was considered that a rib resection would not result in serious respiratory compromise and the complete resection of the tumor would be superior to radiation therapy for local control.
  • Some authors have reported that the surgical resection of a primary lymphoma of the bone originating in a rib can yield a good prognosis.
  • However, it is a systemic disease and a more effective therapeutic strategy should be developed.
  • [MeSH-major] Bone Neoplasms / surgery. Lymphoma, B-Cell / surgery. Lymphoma, Non-Hodgkin / surgery. Ribs

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  • (PMID = 10793497.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
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19. Shon ChN, Baev S: [Diagnosis and treatment of primary retroperitoneal extra-organic tumors]. Khirurgiia (Sofiia); 2000;56(3-4):43-50

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  • [Title] [Diagnosis and treatment of primary retroperitoneal extra-organic tumors].
  • Most of PRET are malignant, a the most frequent malignant PRET are soft tissue sarcomas.
  • Because of their specific localization PRETs grow silently for a relatively long period and are often considerably large at the time of diagnosis.
  • Computerized tomography and magnetic resonance imaging are the most useful methods in the diagnosis of PRET.
  • Surgery is the only effective treatment of PRET with exclusion of some histologic types as lymphoma and malignant germ cell tumors.
  • For the malignant PRET, especially the retroperitoneal soft tissue sarcomas, no adjuvant therapy has proved to be beneficial on survival.
  • [MeSH-major] Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Biomarkers, Tumor. Drug Therapy. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 11692918.001).
  • [ISSN] 0450-2167
  • [Journal-full-title] Khirurgii︠a︡
  • [ISO-abbreviation] Khirurgiia (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Schrofer C, Villiger P, Cathomas R: [Multiple primary neoplasms - coincidence or tumor syndrom?]. Praxis (Bern 1994); 2009 Sep 9;98(18):1027-31
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  • BACKGROUND: Multiple primary neoplasms occur either by hazard or in the context of hereditary cancer syndromes, after chronic toxic exposition, in immunodeficiency or as secondary malignancies after radio- and/or chemotherapy.
  • CASE REPORT: We present the history of an actually asymptomatic female patient with four different malignancies within 30 years: malignant melanoma (1976), liposarcoma (1983), carcinoma of the appendix (2006) and lymphoma (2006).
  • DISCUSSION: There is not only a remarkable variety of malignant tumors but also an extraordinary long survival without recurrence of the generalised malignomas of the skin and soft tissue (malignant melanoma and liposarcoma).
  • It is difficult to explain the entire restitution with the implemented treatments (several tumor resections, chemotherapy with Ifosfamide).
  • More than 20 years after chemotherapy, the lymphoma can be classified as a secondary malignoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Appendiceal Neoplasms / diagnosis. Ileal Neoplasms / diagnosis. Liposarcoma / diagnosis. Lymphoma, Follicular / diagnosis. Melanoma / diagnosis. Neoplasms, Second Primary / diagnosis. Skin Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Humans. Lymph Nodes / pathology. Neoplasm Staging. Syndrome

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  • (PMID = 19739050.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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21. van den Berg H, van Rijn RR, Merks JH: Management of tumors of the chest wall in childhood: a review. J Pediatr Hematol Oncol; 2008 Mar;30(3):214-21
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  • Chest wall tumors in childhood are major challenges with respect to diagnostic workup and treatment.
  • Incidence rate is less than 1 per 1,000,000 and various benign and malignant diseases are noted.
  • From the malignant diseases, Ewing tumors and rhabdomyosarcoma tumors are most often seen.
  • Depending on diagnosis, staging, and age, therapy has to be tailored for each patient, which should be discussed in a multidisciplinary team setting.
  • Radical resection is in most cases the major component of treatment.
  • Use of chemotherapy depends on the diagnosis.
  • In soft-tissue tumors, previously considered to be chemotherapy insensitive, favorable results are currently reported.
  • [MeSH-major] Lymphoma / therapy. Neuroblastoma / therapy. Rhabdomyosarcoma / therapy. Sarcoma, Ewing / therapy. Thoracic Neoplasms / therapy. Thoracic Wall / pathology
  • [MeSH-minor] Child. Combined Modality Therapy. Female. Humans. Male. Predictive Value of Tests

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  • (PMID = 18376284.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 63
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22. Mozek C, Novotny J, Dührsen U, Metz KA: [Lymphadenopathy in the groin. Unusual etiology in a 65-year-old patient]. Internist (Berl); 2004 Jan;45(1):90-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 65 year old female patient was admitted to our hospital with unspecific symptoms and a lump in the right groin which raised suspicion of a malignant lymphoma.
  • Because there are aggressive forms of this tumor and no established standard therapy, we decided to treat her with surgery followed by a combined radio- and chemotherapy.
  • Despite this treatment 16 months after the first diagnosis a relapse occurred with a metastasis of the follicular dendritic cell tumor in the lung.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Groin. Lymph Nodes / pathology. Lymphoma, Large B-Cell, Diffuse / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Prognosis

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  • (PMID = 14735246.001).
  • [ISSN] 0020-9554
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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23. Cheng L, Foster SR, MacLennan GT, Lopez-Beltran A, Zhang S, Montironi R: Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum? J Urol; 2008 Oct;180(4):1235-40
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  • PURPOSE: Inflammatory myofibroblastic tumor of the genitourinary tract is a spindled soft tissue lesion that is often mistaken for sarcoma.
  • We investigated whether inflammatory myofibroblastic tumors in adults and children are the same entity, and whether inflammatory myofibroblastic tumor is part of a biological spectrum that includes benign and malignant entities at opposite ends.
  • RESULTS: The literature suggests that with evidence of anaplastic lymphoma kinase rearrangement and expression, the lesion is neoplastic rather than reactive, differentiating it from previously described lesions.
  • CONCLUSIONS: Inflammatory myofibroblastic tumor of the genitourinary tract should be considered a neoplasm of uncertain malignant potential, and routine surveillance and close clinical followup are recommended.
  • Aggressive therapy (radical cystectomy, radiation or chemotherapy) is unwarranted given the indolent and often benign clinical course for the majority of cases.
  • To understand the diagnostic and prognostic implications future emphasis should be placed on the link between genetic abnormalities, and clinical course, therapeutic response and ultimate outcome.
  • [MeSH-minor] Biopsy, Needle. Diagnosis, Differential. Humans. Immunohistochemistry. Incidence. Neoplasm Staging. Prognosis. Risk Assessment. Ureteral Neoplasms / diagnosis. Ureteral Neoplasms / pathology. Urethral Neoplasms / diagnosis. Urethral Neoplasms / pathology. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18707729.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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24. Hornick JL, Jaffe ES, Fletcher CD: Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol; 2004 Sep;28(9):1133-44
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  • Histiocytic sarcoma is a rare malignant neoplasm that occurs in lymph nodes, skin, and the gastrointestinal tract.
  • Many previously published cases were likely misdiagnosed examples of non-Hodgkin lymphoma.
  • Seven tumors arose in soft tissue (6 lower limb; 1 upper limb), 5 in the gastrointestinal tract (1 involving both stomach and colon, 1 ileum, 2 rectum, 1 anus), 1 in the nasal cavity, and 1 in the lung.
  • Six patients were treated with postoperative radiation and 7 with chemotherapy (CHOP or ProMACE-MOPP).
  • Two tumors recurred locally, and 5 patients developed distant spread: 3 to lymph nodes, 1 to lung, and 1 to bone.
  • At the last follow-up, 2 patients have died of disseminated disease, 4 and 5 months following initial diagnosis.
  • Histiocytic sarcoma may arise primarily in soft tissue and shows reproducible histologic features, including abundant eosinophilic cytoplasm and a prominent inflammatory infiltrate.

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  • (PMID = 15316312.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Akçay MN: Metastatic disease in the breast. Breast; 2002 Dec;11(6):526-8
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  • Metastatic disease of the breast is therefore often an unexpected diagnosis in a female patient presenting with a breast mass.
  • Of solid tumors at other sites, the most common cancers to metastasize to the breast are, in declining order of frequency, malignant melanoma, lymphoma, lung cancer, ovarian carcinoma, soft tissue sarcoma, and gastrointestinal and genitourinary tumors.
  • Diagnosis is generally achieved by means of fine-needle aspiration cytology or open biopsy of the breast masses.
  • In recent reports, particular importance has been attached to the performance of fine-needle aspiration cytology diagnosis, to differentiate a metastasis from a second primary tumor, thus making it possible to avoid unnecessary mastectomy and ensure that appropriate chemotherapy and radiotherapy are implemented.

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  • (PMID = 14965721.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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