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1. Jayanthi V, Randhir J, Rajesh N: Problems in diagnosing lymphoma of the pancreas with computed tomography. A case report. J Gastrointestin Liver Dis; 2007 Mar;16(1):101-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Problems in diagnosing lymphoma of the pancreas with computed tomography. A case report.
  • Primary lymphoma of the pancreas is a rare form of extranodal lymphoma accounting for less than 0.5% of pancreatic tumors.
  • Percutaneous fine-needle aspiration of the pancreas with histopathological examination and immunohistochemical assay confirm the diagnosis.
  • A 73 year old male presented with recurrent pancreatic type abdominal pain with significant weight loss over 1 year.
  • Contrast enhanced CT showed an ill defined poorly marginated non enhancing hypodense mass lesion involving the body of the pancreas.
  • It was negative for CD3 and CD 20 indicating an undifferentiated lymphoma.
  • Patient received two sessions of chemotherapy and was followed-up.
  • [MeSH-major] Adenocarcinoma / radiography. Lymphoma / radiography. Pancreatic Neoplasms / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 17410296.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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2. Grimison PS, Chin MT, Harrison ML, Goldstein D: Primary pancreatic lymphoma--pancreatic tumours that are potentially curable without resection, a retrospective review of four cases. BMC Cancer; 2006;6:117
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic lymphoma--pancreatic tumours that are potentially curable without resection, a retrospective review of four cases.
  • BACKGROUND: Primary pancreatic lymphomas (PPL) are rare tumours of the pancreas.
  • Symptoms, imaging and tumour markers can mimic pancreatic adenocarcinoma, but they are much more amenable to treatment.
  • Treatment for PPL remains controversial, particularly the role of surgical resection.
  • METHODS: Four cases of primary pancreatic lymphoma were identified at Prince of Wales Hospital, Sydney, Australia.
  • All patients were treated with chemotherapy and radiotherapy, and two of four patients received rituximab.
  • Outcomes in our series and other series of chemotherapy and radiotherapy compared favourably to surgical series.
  • CONCLUSION: Biopsy of all pancreatic masses is essential, to exclude potentially curable conditions such as PPL, and can be performed without laparotomy.
  • Combined multimodality treatment, utilising chemotherapy and radiotherapy, without surgical resection is advocated but a cooperative prospective study would lead to further improvement in treatment outcomes.
  • [MeSH-major] Lymphoma, Non-Hodgkin / therapy. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Aged. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Agents / therapeutic use. Biopsy. Combined Modality Therapy. Humans. Male. Middle Aged. Pancreas / pathology. Retrospective Studies. Rituximab. Treatment Outcome

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  • (PMID = 16674812.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
  • [Number-of-references] 49
  • [Other-IDs] NLM/ PMC1475874
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3. Yoon WJ, Yoon YB, Kim YJ, Ryu JK, Kim YT: Primary pancreatic lymphoma in Korea--a single center experience. J Korean Med Sci; 2010 Apr;25(4):536-40
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  • [Title] Primary pancreatic lymphoma in Korea--a single center experience.
  • The aim of this study was to report a single center experience of primary pancreatic lymphoma (PPL) in Korea.
  • The diagnoses were: diffuse large B cell lymphoma (n=2), Ki-1 (+) anaplastic large cell lymphoma (n=1), and Burkitt lymphoma (n=1).
  • Two patients underwent treatment.
  • The stage IEA patient underwent chemotherapy and radiation therapy that resulted in a complete remission.
  • The stage IVEB patient who underwent chemotherapy relapsed.
  • Two patients (stages IVEB and IIEA) without treatment died at 0.8 and 7.0 months, respectively.
  • For PPL patients, chemotherapy-based treatment, and addition of radiation therapy, if possible, may offer good prognosis.
  • [MeSH-major] Lymphoma / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Korea. Male. Middle Aged. Prognosis. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 20357994.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2844603
  • [Keywords] NOTNLM ; Lymphoma / Pancreas
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4. Luo G, Jin C, Fu D, Long J, Yang F, Ni Q: Primary pancreatic lymphoma. Tumori; 2009 Mar-Apr;95(2):156-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic lymphoma.
  • AIMS AND BACKGROUNDS: Primary pancreatic lymphoma is non-Hodgkin lymphoma primarily involving the pancreas, which is rare in pancreatic diseases.
  • The aim of this work is to summarize the diagnostic and therapeutic experience of primary pancreatic lymphoma.
  • METHODS: We retrospectively reviewed the clinical data of 7 cases of primary pancreatic lymphoma admitted to Huashan Hospital in the past 3 years.
  • Available English literature was also reviewed using the following terms: primary pancreatic lymphoma and pancreatic lymphoma.
  • In this series, only 30% had a successful non-operative diagnosis.
  • The curative rate of the surgery-adjuvant chemotherapy group was higher than that of the chemotherapy alone group.
  • Surgical resection in combination with postoperative chemotherapy plays a therapeutic role.
  • [MeSH-major] Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. China. Female. Humans. Male. Middle Aged. Pancreatectomy. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19579860.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Merkle EM, Bender GN, Brambs HJ: Imaging findings in pancreatic lymphoma: differential aspects. AJR Am J Roentgenol; 2000 Mar;174(3):671-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging findings in pancreatic lymphoma: differential aspects.
  • When the radiologist is faced with a well-circumscribed tumoral mass in the pancreas, knowing when to direct the patient toward nonsurgical biopsy instead of surgical biopsy and staging is critical.
  • Lymphoma does not require surgical staging or a palliative Whipple's procedure before chemotherapy or radiation therapy.
  • A better overall prognosis with nonsurgical treatment is additional impetus to search for secondary signs of primary pancreatic lymphoma.
  • In patients with primary pancreatic lymphoma, no marked pancreatic ductal dilatation is present even with ductal invasion.
  • Adenocarcinoma commonly dilates the more distal pancreatic duct when more proximal ductal invasion has taken place.
  • Lymph node involvement below the level of the renal veins was another finding not seen with adenocarcinoma.
  • Clinical and imaging findings are otherwise not specific in the differentiation of pancreatic lymphoma and pancreatic cancer, but a bulky homogeneous tumoral mass without alteration of Wirsung's duct or the peripancreatic vessels should suggest the diagnosis.
  • In patients with diffuse infiltration of the pancreatic gland without clinical signs of pancreatitis, the radiologist should be alert to the possibility of pancreatic lymphoma.
  • [MeSH-major] Diagnostic Imaging. Lymphoma, Non-Hodgkin / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pancreas / pathology

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  • (PMID = 10701607.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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6. Lin H, Li SD, Hu XG, Li ZS: Primary pancreatic lymphoma: report of six cases. World J Gastroenterol; 2006 Aug 21;12(31):5064-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic lymphoma: report of six cases.
  • AIM: To heighten recognition of primary pancreatic lymphoma (PPL) in clinical practice.
  • METHODS: A retrospective review of the clinical presentation, imaging characteristics and pathological features of PPL patients were presented, as well as their diagnosis and treatment, in combination with literature review.
  • RESULTS: Histological diagnosis was made in four patients by surgery and in two patients by EUS-FNA.
  • One of the patients developed acute pancreatitis.
  • Abdominal CT scan showed that three of the six tumors were located in the head of pancreas, two in the body and tail, and one throughout the pancreas.
  • Diameter of the tumors in the pancreas in four cases was more than 6 cm, with homogeneous density and unclear borders.
  • The pancreatic duct was irregularly narrowed in two cases whose tumors were located in the pancreatic head and body, in which endoscopic retrograde cholangiopancreatography (ERCP) showed that the proximal segment was slightly dilated.
  • The diagnosis of B-cell non-Hodgkin's lymphoma was made in all patients histopathologically.
  • All six patients underwent systemic chemotherapy, one of whom was also treated with gamma radiometry.
  • One patient died two weeks after diagnosis, two patients lost follow-up, two patients who received chemotherapy survived 49 and 37 mo, and the remaining patient is still alive 21 mo, after diagnosis and treatment.
  • CONCLUSION: PPL is a rare form of extranodal lymphoma originating from the pancreatic parenchyma.
  • Clinical and imaging findings are otherwise not specific in the differentiation of pancreatic lymphoma and pancreatic cancer, which deserves attention.
  • EUS-guided fine-needle aspiration (EUS-FNA) of the pancreas requires experienced cytopathologists as well as advanced immunohistochemical assays to obtain a final diagnosis on a small amount of tissue.
  • Surgery and adjuvant chemotherapy or radiotherapy can produce fairly good outcomes.
  • [MeSH-major] Lymphoma / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 16937508.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087415
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7. Liakakos T, Misiakos EP, Tsapralis D, Nikolaou I, Karatzas G, Macheras A: A role for surgery in primary pancreatic B-cell lymphoma: a case report. J Med Case Rep; 2008;2:167
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A role for surgery in primary pancreatic B-cell lymphoma: a case report.
  • INTRODUCTION: Primary pancreatic lymphoma is a very rare but manageable malignant tumour which may be clinically confused as a pancreatic carcinoma.
  • This case report demonstrates the value of surgical resection in the management of pancreatic lymphoma.
  • Ultrasonography and computed tomography showed a mass at the head of the pancreas which was compressing the bile duct.
  • Histopathologic and immunohistochemical assessment of the pancreatic lesion established the diagnosis of a diffuse, extranodal, high-grade B-cell non-Hodgkin's lymphoma.
  • Several doses of chemotherapy were administered postoperatively and at present the disease remains in remission.
  • CONCLUSION: The favourable outcome for this patient and a thorough review of the literature underline the important role that operative resection may have in the management of at least the early stage of primary pancreatic lymphoma.

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  • (PMID = 18489739.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2396657
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8. Haji AG, Sharma S, Majeed KA, Vijaykumar DK, Pavithran K, Dinesh M: Primary pancreatic lymphoma: Report of three cases with review of literature. Indian J Med Paediatr Oncol; 2009 Jan;30(1):20-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic lymphoma: Report of three cases with review of literature.
  • BACKGROUND: Primary pancreatic lymphoma (PPL) is an extremely rare neoplasm, which may be confused with pancreatic adenocarcinoma.
  • Two patients had diagnosis confirmed histologically by CT-guided core biopsy or Fine needle aspiration procedure.
  • We were able to avoid unnecessary laparotomy in 2 patients using preoperative guided Fine needle aspiration Cytology, although the third patient did undergo a Whipple's procedure as the diagnosis of PPL was not considered during the initial workup.
  • CONCLUSIONS: There is no significant difference noted with regard to patient's age or duration of symptoms between patients with either pancreatic adenocarcinoma or PPL.
  • The differential diagnosis of PPL includes pancreatic adenocarcinoma and secondary involvement of pancreas from extra-nodal lymphoma.
  • Combination of two things is suggestive of Pancreatic lymphoma:.
  • (1) Bulky localized tumor in pancreatic head (2) Absence of significant dilatation of main pancreatic duct strengthens a diagnosis of pancreatic lymphoma over adenocarcinoma.
  • Majority of patients can be managed with chemotherapy with much better prognosis compared to patients with pancreatic adenocarcinoma.
  • Larger series of patients are needed to evaluate whether chemotherapy, eventually followed by involved-field radiation therapy, is the treatment of choice for PPL.

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  • (PMID = 20668602.001).
  • [ISSN] 0975-2129
  • [Journal-full-title] Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
  • [ISO-abbreviation] Indian J Med Paediatr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2902210
  • [Keywords] NOTNLM ; Pancreatic lymphoma / neoplasm / pancreatic adenocarcinoma
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9. Aftandilian CC, Friedmann AM: Burkitt lymphoma with pancreatic involvement. J Pediatr Hematol Oncol; 2010 Nov;32(8):e338-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Burkitt lymphoma with pancreatic involvement.
  • Intraoperative biopsies confirmed Burkitt lymphoma.
  • Further imaging and biopsy revealed pancreatic involvement.
  • He was treated with multiagent chemotherapy.
  • Review of the literature demonstrates other cases of non-Hodgkin lymphoma with pancreatic involvement with good outcomes.
  • Pancreatic involvement is a relatively rare occurrence in childhood lymphoma.
  • [MeSH-major] Burkitt Lymphoma / pathology. Oropharyngeal Neoplasms / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Child. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 20930650.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. van Wensen RJ, Bosscha K, Jager GJ, van der Linden JC, Fijnheer R: [An invasive process in the pancreas: sometimes lymphoma]. Ned Tijdschr Geneeskd; 2009;153:B164
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [An invasive process in the pancreas: sometimes lymphoma].
  • [Transliterated title] Een ruimte-innemend proces in het pancreas: soms een lymfoom.
  • An invasive process in the pancreas was found in a 60-year-old woman and a 50-year-old man with abdominal symptoms.
  • However, these patients had lymphoma.
  • Primary pancreatic lymphoma or localization of lymphoma in the pancreas are rare and chemotherapy may be curative.
  • Therefore, obtaining tissue for histopathological confirmation of the diagnosis is very important.
  • Both patients underwent chemotherapy.
  • The first patient was in complete remission one month after the last chemotherapy cycle.
  • In the second, the disease went into remission, but he suddenly died of sepsis after the fourth chemotherapy cycle.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Lymphoma / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Fatal Outcome. Female. Humans. Immunohistochemistry. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19818177.001).
  • [ISSN] 1876-8784
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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11. Shahar KH, Carpenter LS, Jorgensen J, Truong L, Baker K, Teh BS: Role of radiation therapy in a patient with primary pancreatic lymphoma. Clin Lymphoma Myeloma; 2005 Sep;6(2):143-5
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  • [Title] Role of radiation therapy in a patient with primary pancreatic lymphoma.
  • Pancreatic lymphoma is an extremely rare disease.
  • The role of radiation therapy as an adjunct to chemotherapy for the treatment of this disease is poorly defined.
  • We present a case of primary pancreatic lymphoma treated with radiation therapy as an adjunct to chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Lymphoma, Large B-Cell, Diffuse / therapy. Pancreatic Neoplasms / therapy. Radiotherapy, Intensity-Modulated
  • [MeSH-minor] Aged. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Humans. Prednisone / administration & dosage. Vincristine / administration & dosage

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  • (PMID = 16231854.001).
  • [ISSN] 1557-9190
  • [Journal-full-title] Clinical lymphoma & myeloma
  • [ISO-abbreviation] Clin Lymphoma Myeloma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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12. Battula N, Srinivasan P, Prachalias A, Rela M, Heaton N: Primary pancreatic lymphoma: diagnostic and therapeutic dilemma. Pancreas; 2006 Aug;33(2):192-4
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  • [Title] Primary pancreatic lymphoma: diagnostic and therapeutic dilemma.
  • OBJECTIVES: Non-Hodgkin lymphoma predominantly involving the pancreas is a rare tumor and accounts for less than 0.7% of all pancreatic malignancies and 1% of extranodal lymphomas.
  • Diagnosis of primary pancreatic lymphoma can be difficult because it may mimic carcinoma.
  • The principal aims of this review were to highlight the difficulties encountered in making a diagnosis and to identify the role of surgery.
  • METHODS: A PubMed search was conducted using the following terms: primary pancreatic lymphoma and non-Hodgkin lymphoma of the pancreas.
  • RESULTS: A total of 89 reported cases of pancreatic lymphoma between 1951 and 2005 were reviewed.
  • An accurate preoperative diagnosis of primary pancreatic lymphoma is not always possible.
  • A complete response rate of 100% and a long-term survival rate of 94% have been reported with surgery and adjuvant chemotherapy when compared with a 5-year survival rate of less than 50% and an overall 3-year disease-free survival rate of 44% with current chemotherapy, radiotherapy, or combined methods.
  • CONCLUSION: Pancreaticoduodenectomy may have a therapeutic role in association with chemotherapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Lymphoma, B-Cell / surgery. Lymphoma, Non-Hodgkin / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16868486.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 34
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13. Koniaris LG, Lillemoe KD, Yeo CJ, Abrams RA, Colemann J, Nakeeb A, Pitt H, Cameron JL: Is there a role for surgical resection in the treatment of early-stage pancreatic lymphoma? J Am Coll Surg; 2000 Mar;190(3):319-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is there a role for surgical resection in the treatment of early-stage pancreatic lymphoma?
  • BACKGROUND: Pancreatic lymphoma is a rare neoplasm.
  • STUDY DESIGN: From March 1983 to July 1997, eight patients with stage I or II primary pancreatic lymphoma were identified and retrospectively reviewed.
  • All patients received chemotherapy, five patients received radiotherapy, and three patients also underwent surgical resection.
  • A review of the published pancreatic lymphoma experience in the English-language literature was also undertaken.
  • RESULTS: Three patients underwent pancreaticoduodenectomy with successful resection of the lymphoma and are disease free at 64, 62, and 53 months followup.
  • Five patients were treated with nonresectional therapy.
  • A review of the pancreatic lymphoma experience in the English-language literature identified 122 cases of pancreatic lymphoma.
  • Fifty-eight of these cases represented stage I or II lymphoma, which was treated without surgical resection with a 46% cure rate.
  • CONCLUSIONS: Based on both our single institution experience and the literature, it is suggested that surgical resection may play a beneficial role in the treatment of localized pancreatic lymphoma, although selection factors cannot be absolutely excluded.
  • [MeSH-major] Lymphoma / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Algorithms. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Female. Humans. Lymphoma, Large B-Cell, Diffuse / drug therapy. Lymphoma, Large B-Cell, Diffuse / radiotherapy. Lymphoma, Large B-Cell, Diffuse / surgery. Male. Middle Aged. Prednisone / therapeutic use. Retrospective Studies. Treatment Outcome. Vincristine / therapeutic use

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  • (PMID = 10703858.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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14. Hauksson IT, Guðbjartsson T, Hrafnkelsson J, Sigurðsson F, Magnússon J: [Primary pancreatic lymphoma causing obstructive jaundice in a 71 year old man. A case report and review of the literature.]. Laeknabladid; 2002 Mar;88(3):189-92

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  • [Title] [Primary pancreatic lymphoma causing obstructive jaundice in a 71 year old man. A case report and review of the literature.].
  • Primary lymphoma of the pancreas is a very rare disease.
  • They are difficult to diagnose and have good prognosis, due to their sensitivity to chemotherapy and radiation.
  • As compared to the more common pancreatic adenocarcinomas which usually have bad prognosis.
  • Histological diagnosis relies on good biopsy.
  • We report a case of primary pancreatic non-Hodgkin s lymphoma diagnosed in a 71 year old icteric man.
  • Chemotherapy and radiation therapy was started after relieving the jaundice with a PTC-introduced stent through the pancreatic part of the choledochus.
  • This is the first reported case of pancreatic lymphoma in Iceland.

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  • (PMID = 16940648.001).
  • [ISSN] 0023-7213
  • [Journal-full-title] Læknablađiđ
  • [ISO-abbreviation] Laeknabladid
  • [Language] ice
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Iceland
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15. Lee MK, Jeon SW, Lee YD, Seo HE, Cho CM, Kim SG, Yoon YK: A case of primary pancreatic non-Hodgkin's lymphoma. Korean J Intern Med; 2006 Jun;21(2):123-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of primary pancreatic non-Hodgkin's lymphoma.
  • Primary pancreatic lymphoma is rare, comprising 0.2-4.9% of all pancreatic malignancies and less than 1% of cases of non-Hodgkin's lymphoma.
  • Many patients are diagnosed with lymphoma after radical resection.
  • We report a rare presentation of diffuse large B cell lymphoma, appearing as a primary tumor of the pancreas.
  • Computed tomography of the abdomen showed a well defined mass located at the head of the pancreas.
  • A frozen section of pancreas, during laparotomy, revealed lymphoma.
  • The patient received 6 cycles of chemotherapy and is currently in complete remission.
  • This case underscores the importance of differentiating primary lymphoma from the more common adenocarcinoma of the pancreas as treatment and prognosis differ significantly.
  • Primary pancreatic lymphoma should be considered in the differential diagnosis of pancreatic tumors and an attempt to obtain a tissue diagnosis is always necessary before proceeding to radical surgery, especially on young patients.
  • [MeSH-major] Lymphoma, B-Cell / therapy. Lymphoma, Large B-Cell, Diffuse / therapy. Pancreatic Neoplasms / therapy

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  • [Cites] J Am Coll Surg. 2000 Mar;190(3):319-30 [10703858.001]
  • [Cites] Med Oncol. 2000 Aug;17(3):237-47 [10962538.001]
  • [Cites] J Hepatobiliary Pancreat Surg. 2000;7(6):610-3 [11180896.001]
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  • (PMID = 16913443.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3890735
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16. Kurosawa H, Matsunaga T, Shimaoka H, Sato Y, Kuwashima S, Sugita K, Hagane K, Eguchi M: Burkitt lymphoma associated with large gastric folds, pancreatic involvement, and biliary tract obstruction. J Pediatr Hematol Oncol; 2002 May;24(4):310-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Burkitt lymphoma associated with large gastric folds, pancreatic involvement, and biliary tract obstruction.
  • Large gastric folds in adults are seen in many benign and malignant conditions, but they are rare in children with malignant diseases such as non-Hodgkin lymphoma.
  • The authors report a patient with non-Hodgkin lymphoma who had large gastric folds and jaundice as the initial symptoms.
  • Magnetic resonance imaging showed a typical diffuse infiltrating type of pancreatic lymphoma.
  • Because complete bilateral lower limb paralysis developed as a result of the epidural soft tissue mass, laminectomy and tumor resection were performed and a diagnosis of disseminated Burkitt lymphoma was established.
  • After completing 6 months of chemotherapy, the patient has been disease-free without neurologic complications for 2.5 years.
  • [MeSH-major] Burkitt Lymphoma / diagnosis. Cholestasis / diagnosis. Gastric Mucosa / pathology. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 11972102.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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17. Matsubayashi H, Takagaki S, Otsubo T, Iiri T, Kobayashi Y, Yokota T, Shichijo K, Iwafuchi M, Kijima H: Pancreatic T-cell lymphoma with high level of soluble interleukin-2 receptor. J Gastroenterol; 2002;37(10):863-7
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  • [Title] Pancreatic T-cell lymphoma with high level of soluble interleukin-2 receptor.
  • Abdominal computed tomography (CT) scan and ultrasonography showed enlargement of the whole pancreas with para-aortic lymphadenopathy.
  • Endoscopic retrograde pancreatography (ERP) showed diffuse narrowing of the main pancreatic duct (MPD), and brushing cytology from the MPD was non-neoplastic.
  • Differential diagnosis between lymphoma and other exocrine and endocrine pancreatic malignancies was needed, and the level of serum soluble interleukin-2 receptor (17 751 U/ml) was revealed to be significantly high, which was strongly suggestive of pancreatic lymphoma.
  • Chemotherapy was refused by the patient's family and the patient succumbed after 2 months of conservative follow-up.
  • Autopsy revealed diffuse, mixed cell-type, non-Hodgkin's lymphoma of T-cell subtype.
  • [MeSH-major] Biomarkers, Tumor / blood. Lymphoma, T-Cell / diagnosis. Pancreatic Neoplasms / diagnosis. Receptors, Interleukin-2 / blood

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  • (PMID = 12424573.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Interleukin-2
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18. Kato H, Naganuma T, Iizawa Y, Kitagawa M, Tanaka M, Isaji S: Primary non-Hodgkin's lymphoma of the gallbladder diagnosed by laparoscopic cholecystectomy. J Hepatobiliary Pancreat Surg; 2008;15(6):659-63
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  • [Title] Primary non-Hodgkin's lymphoma of the gallbladder diagnosed by laparoscopic cholecystectomy.
  • Primary lymphoma of the gallbladder is an exceedingly rare disease.
  • We experienced an asymptomatic case of primary non-Hodgkin's lymphoma of the gallbladder in a 55-year-old woman in whom laparoscopic cholecystectomy made a definite diagnosis.
  • Abdominal computed tomography revealed a 4-cm gallbladder tumor with markedly enlarged lymph nodes in the retropancreatic area.
  • Despite the marked involvement of lymph nodes, serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 were not elevated.
  • The discrepancy between the imaging findings and the patient's mild clinical presentation led us to suspect that the tumor was a lymphoma.
  • We examined serum markers of lymphoma, revealing slight elevations of interleukin (IL)-2 receptor and thymidine kinase.
  • Laparoscopic cholecystectomy for a total biopsy was performed successfully, and the results of intraoperative frozen-section examination led us to have a high suspicion of malignant lymphoma.
  • The final diagnosis was large diffuse B-cell lymphoma of the gallbladder with a positive CD20 antibody reaction.
  • The patient received postoperative chemotherapy with R-CHOP (rituximab, 500 mg; cyclophosphamide, 1000 mg; adriamycin, 68 mg; vincristine, 1.9 mg; and prednisone, 80 mg) starting on postoperative day 12.
  • In conclusion, gallbladder lymphoma should be added to the differential diagnosis of gallbladder tumors, especially when the imaging findings and clinical presentation are not consistent with typical signs of gallbladder carcinoma, and laparoscopic cholecystectomy is helpful for the confirmation of suspicious cases.
  • [MeSH-major] Cholecystectomy, Laparoscopic. Gallbladder Neoplasms / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Combined Modality Therapy. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Female. Humans. Lymphatic Metastasis. Middle Aged. Prednisone / therapeutic use. Rituximab. Tomography, X-Ray Computed. Vincristine / therapeutic use

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  • (PMID = 18987940.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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19. Boni L, Benevento A, Dionigi G, Cabrini L, Dionigi R: Primary pancreatic lymphoma. Surg Endosc; 2002 Jul;16(7):1107-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic lymphoma.
  • Primary pancreatic lymphoma (PPL) is a rare form of extranodal lymphoma (less than 0.5% of pancreatic tumors) originating from the pancreatic parenchyma.
  • Histopathological examination is usually mandatory to obtain a definitive diagnosis since symptoms and radiological features are quite similar to those of other pancreatic masses.
  • Percutaneous fine-needle aspiration (FNA) of the pancreas requires experienced cytopathologists as well as advanced immunohistochemical assays to obtain a final diagnosis on a small amount of tissue.
  • Enlarged lymph nodes (2.5 x 1 cm) were found at the right axillary stations.
  • Abdominal ultrasound revealed the presence of a large hyperechogenic mass, mainly located at the pancreatic head.
  • Abdominal computed tomography scan confirmed a diffuse enlargement of the head and body of the pancreas associated with lymphadenopathy along the lesser gastric curvature.
  • Percutaneous ultrasound-guided FNA of the pancreas as well as gross biopsy of the axillary lymph nodes were unable to identify the nature of the mass.
  • Diagnostic laparoscopy was performed: several enlarged lymph nodes along the lesser gastric curvature were revealed.
  • Multiple biopsies of the pancreatic head were taken and lymphadenectomy along the lesser curvature and the hepatic hilus was also performed.
  • The definitive histopathological examination of the pancreatic specimen revealed a primary low-grade non-Hodgkin B cell pancreatic lymphoma.
  • The postoperative course was unremarkable; the patient underwent systemic chemotherapy regime for low-grade B cell Hodgkin lymphoma and he was symptom free at 9-month follow-up.
  • [MeSH-major] Lymphoma, B-Cell / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Diabetes Mellitus, Type 1 / surgery. Diagnostic Techniques, Surgical. Humans. Laparoscopy / methods. Lymph Node Excision / methods. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 11984658.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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20. Szende B, Kéri G: TT-232: a somatostatin structural derivative as a potent antitumor drug candidate. Anticancer Drugs; 2003 Sep;14(8):585-8
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  • [Title] TT-232: a somatostatin structural derivative as a potent antitumor drug candidate.
  • TT-232 (D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2) has been developed as an antitumor somatostatin analog.
  • This analog induces apoptosis in and exerts pronounced antiproliferative effects on various human tumors (colon, pancreas, lymphoma, leukemia, melanoma, hepatoma) cell lines.
  • The growth of human xenografts (prostate, breast carcinoma, lymphoma, melanoma) and animal tumors (colon-26, P-388, S-180, B16, MXT) was inhibited by TT-232 (dose range: 30-750 microg/kg/day) in 54-98% of cases.
  • TT-232 combined with decarbazine or etoposide treatment enhanced the antitumor activity of these drugs on human melanoma and lymphoma xenografts, respectively.
  • TT-232 may be a promising candidate in the therapy of human malignancies.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Neoplasms / drug therapy. Peptides, Cyclic / pharmacology. Somatostatin / analogs & derivatives. Somatostatin / pharmacology
  • [MeSH-minor] Animals. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Apoptosis. Cell Line, Tumor. Dacarbazine / administration & dosage. Etoposide / administration & dosage. Humans

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  • (PMID = 14501379.001).
  • [ISSN] 0959-4973
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Peptides, Cyclic; 0 / TT2-32; 51110-01-1 / Somatostatin; 6PLQ3CP4P3 / Etoposide; 7GR28W0FJI / Dacarbazine
  • [Number-of-references] 17
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21. Arcari A, Anselmi E, Bernuzzi P, Bertè R, Lazzaro A, Moroni CF, Trabacchi E, Vallisa D, Vercelli A, Cavanna L: Primary pancreatic lymphoma. Report of five cases. Haematologica; 2005 Feb;90(2):ECR09
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic lymphoma. Report of five cases.
  • Primary pancreatic lymphoma (PPL) is a very rare disease.
  • None of these patients had evidence of extrapancreatic disease and they were categorized as PPL involving pancreas only (stage IE, 3 patients) or pancreas and peripancreatic lymph nodes (stage IIE, 2 patients).
  • Imaging techniques showed a mass of the pancreatic head in all cases.
  • The histological diagnosis (3 diffuse-large cell non-Hodgkin's lymphoma and 2 lymphoplasmacytic lymphoma/immunocytoma) was made by ultrasound-guided fine needle aspiration biopsy and tissue core fine-needle biopsy in three patients and by surgery in the remaining two patients.
  • The three patients diagnosed by percutaneous biopsy were treated with chemotherapy as front-line therapy and two of them received also local radiotherapy; one of these patients is still alive in complete remission at 69 months, one died of an unrelated disease at 67 months and one died of lymphoma relapse at 88 months.
  • Two patients underwent pancreaticoduodenectomy plus adjuvant chemotherapy; one of them died of recurrent cholangitis 8 months after surgery while the other one is still alive in complete remission after 160 months.
  • 1) imaging techniques can suggest the suspicion of PPL but are unable to distinguish PPL from pancreatic adenocarcinoma;.
  • 2) histological diagnosis can be easily obtained by percutaneous US-guided tissue core biopsy;.
  • 3) surgery can be avoided both for diagnosis and therapy but the treatment of choice of PPL may only be evaluated on a larger series of patients.
  • [MeSH-major] Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Aged. Biopsy. Biopsy, Needle. Female. Humans. Male. Middle Aged. Recurrence. Remission Induction. Retrospective Studies. Treatment Outcome

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  • (PMID = 15713583.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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22. Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A; 2010 Feb 2;107(5):2037-42
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  • Furthermore, we document that FX11 inhibited the progression of sizable human lymphoma and pancreatic cancer xenografts.
  • When used in combination with the NAD(+) synthesis inhibitor FK866, FX11 induced lymphoma regression.
  • Hence, inhibition of LDHA with FX11 is an achievable and tolerable treatment for LDHA-dependent tumors.

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  • (PMID = 20133848.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA057341; United States / NCI NIH HHS / CA / R01CA113669; United States / NCI NIH HHS / CA / R01CA57341; United States / NCI NIH HHS / CA / P01 CA134292; United States / NCI NIH HHS / CA / R01 CA051497; United States / NCI NIH HHS / CA / R01 CA113669; United States / NCI NIH HHS / CA / R01CA051497; United States / NCI NIH HHS / CA / P01CA134292
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propylnaphthalene-1-carboxylic acid; 0 / Antioxidants; 0 / Enzyme Inhibitors; 0 / Isoenzymes; 0 / Naphthalenes; 0 / RNA, Small Interfering; 8L70Q75FXE / Adenosine Triphosphate; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 1.1.1.27.- / lactate dehydrogenase 5; WYQ7N0BPYC / Acetylcysteine
  • [Other-IDs] NLM/ PMC2836706
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23. Nayer H, Weir EG, Sheth S, Ali SZ: Primary pancreatic lymphomas: a cytopathologic analysis of a rare malignancy. Cancer; 2004 Oct 25;102(5):315-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic lymphomas: a cytopathologic analysis of a rare malignancy.
  • BACKGROUND: Primary pancreatic lymphomas (PPL) are extremely rare.
  • Clinically, PPL usually present with symptoms of carcinoma of the pancreatic head.
  • An accurate cytopathologic diagnosis by fine-needle aspiration (FNA) is imperative because the primary treatment is nonsurgical, based on a combination of chemotherapy and radiation therapy.
  • No tissue studies were performed after the FNA diagnosis was made.
  • The patients were treated with either chemotherapy alone or in conjunction with radiation therapy or stem cell transplantation.
  • FNA coupled with FC analysis appears to be highly accurate in the diagnosis of PPL and is the sole diagnostic modality used clinically.
  • Based on cytomorphology, the main differential diagnoses of PPL involve secondary lymphoma, pancreatic endocrine neoplasm, and florid chronic pancreatitis.
  • An accurate FNA diagnosis of PPL is critical for timely, nonsurgical management and obviates the need for an exploratory laparotomy.
  • [MeSH-major] Lymphoma / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Flow Cytometry. Humans. Immunophenotyping. Male. Middle Aged. Sex Factors

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  • (PMID = 15386314.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Basu A, Patil N, Mohindra P, Zade B, Gujral S, Muckaden MA, Laskar S: Isolated non-Hodgkin's lymphoma of the pancreas: case report and review of literature. J Cancer Res Ther; 2007 Oct-Dec;3(4):236-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated non-Hodgkin's lymphoma of the pancreas: case report and review of literature.
  • BACKGROUND: Isolated primary pancreatic lymphoma (PPL) is a rare extra-lymphatic non-Hodgkin's lymphoma comprising less than 1% of all extra-lymphatic lymphomas.
  • It is difficult to diagnose; the vague presenting symptoms and nonspecific laboratory/radiological findings make it difficult to differentiate the condition from pancreatic adenocarcinoma.
  • Histopathological examination is of paramount importance to conclusively establish the diagnosis since the treatment involves lymphoma protocols, and prognosis and survival in PPL are considerably superior to that in adenocarcinoma pancreas.
  • RESULT: The patient was treated with multi-agent combination chemotherapy followed by radiotherapy.
  • DISCUSSION: A review of literature was done using a Medline search to determine the incidence and prevalence of isolated PPL and to note the diagnosis and management of previously reported cases.
  • CONCLUSION: An exceedingly rare entity, isolated PPLs need to be differentiated from pancreatic adenocarcinomas by histopathological evaluation since management is on the lines of other extralymphatic lymphomas and prognosis is significantly better.
  • [MeSH-major] Lymphoma, Non-Hodgkin / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Humans. Male. Prognosis. Treatment Outcome

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  • (PMID = 18270400.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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25. Saif MW: Primary pancreatic lymphomas. JOP; 2006;7(3):262-73
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  • [Title] Primary pancreatic lymphomas.
  • Primary pancreatic lymphomas are extremely rare.
  • Clinically, primary pancreatic lymphomas usually present with symptoms of carcinoma of the pancreatic head.
  • Patients with primary pancreatic lymphomas are between 35 and 75 years of age and with a strong male predominance.
  • An accurate cytopathologic diagnosis by fine-needle aspiration (FNA) is imperative because the primary treatment is non-surgical.
  • FNA coupled with flow cytometry analysis appears to be highly accurate in the diagnosis of primary pancreatic lymphomas.
  • Fluorescence in-situ hybridisation technique has been established its role in the diagnosis of lymphoid malignancies, including primary pancreatic lymphomas.
  • The differential diagnoses of primary pancreatic lymphomas include secondary lymphoma, pancreatic endocrine neoplasm, and florid chronic pancreatitis.
  • Treatment usually consists of a combination of chemotherapy and radiation therapy, or stem cell transplantation.
  • Primary pancreatic lymphomas has a much better prognosis than adenocarcinoma of the pancreas.
  • [MeSH-major] Lymphoma / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 16685107.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 40
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26. Nishimura R, Takakuwa T, Hoshida Y, Tsujimoto M, Aozasa K: Primary pancreatic lymphoma: clinicopathological analysis of 19 cases from Japan and review of the literature. Oncology; 2001;60(4):322-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic lymphoma: clinicopathological analysis of 19 cases from Japan and review of the literature.
  • Primary pancreatic lymphoma (PL) is an extremely rare disease, and large-scale studies are rarely performed even in Western countries, in which all cases of PL reported to date were of the B-cell type.
  • Tumors were located in the pancreatic head (12 cases), tail (4 cases) and body (2 cases), and ranged in size from 4 to 17 cm.
  • Radical resection was performed in 10 cases and bypass operation in 1, followed by chemotherapy in 8.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Lymphoma, T-Cell / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunophenotyping. Japan. Male. Middle Aged. Neoplasm Staging. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright 2001 S. Karger AG, Basel.
  • (PMID = 11408800.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 16
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27. Cohen Y, Libster D, Amir G, Hiller N, Da'as N, Ben Yehuda D, Polliack A: Primary ALK positive anaplastic large cell lymphoma of the pancreas. Leuk Lymphoma; 2003 Jan;44(1):205-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary ALK positive anaplastic large cell lymphoma of the pancreas.
  • Here we present an unusual case of anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALCL), appearing as a primary tumor of the pancreas which invaded into the adjacent duodenal wall, causing upper gastrointestinal bleeding.
  • After complete resection of the tumor (Whipple's operation), the patient received 4 cycles of CHOP chemotherapy.
  • Currently, 2 years after diagnosis the patient still remains lymphoma free.
  • Primary ALCL of the pancreas is very rare and has only been reported on one previous occasion.
  • Nevertheless, lymphoma should be considered in the differential diagnosis of pancreatic tumors and an attempt to obtain tissue diagnosis is always necessary before continuing with radical surgery, especially in young patients.
  • [MeSH-major] Lymphoma, Large-Cell, Anaplastic / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / etiology. Duodenal Neoplasms / therapy. Humans. Immunophenotyping. Male. Necrosis. Neoplasm Invasiveness / pathology. Remission Induction / methods


28. Petit T, Davidson KK, Lawrence RA, von Hoff DD, Izbicka E: Neuropeptide receptor status in human tumor cell lines. Anticancer Drugs; 2001 Feb;12(2):133-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor types expressing a neuroendocrine phenotype secrete neuropeptides with paracrine or autocrine growth factor activity.
  • Once specific receptors are identified, specific neuropeptide antagonists disrupting paracrine and autocrine loops could be potential treatments in neuropeptide-secreting tumors.
  • In the present study, 11 human tumor cell lines representing astrocytoma, lymphoma, and pancreatic, prostate, lung and colon carcinomas were examined for expression of five different neuropeptide receptors (cholecystokinin, neurotensin, vasopressin, tachykinine substance P and cannabinoid) using RT-PCR and radioligand binding.
  • The presence of various neuropeptide receptors in different human cancer cell lines supports development of new antitumor treatments based on disruption of neuropeptide autocrine growth pathways.
  • [MeSH-minor] Cell Division / drug effects. DNA Primers / chemistry. Humans. RNA, Messenger / metabolism. RNA, Neoplasm / metabolism. Radioligand Assay. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 11261886.001).
  • [ISSN] 0959-4973
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptors, Neuropeptide
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29. Levy MJ, Wiersema MJ: Endoscopic removal of a biliary Wallstent with a suture-cutting device in a patient with primary pancreatic lymphoma. Endoscopy; 2002 Oct;34(10):835-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic removal of a biliary Wallstent with a suture-cutting device in a patient with primary pancreatic lymphoma.
  • This report describes the case of a 74-year-old woman who had previously had a metal stent placed to relieve jaundice resulting from a pancreatic head tumor, suspected to be adenocarcinoma.
  • The tumor was subsequently found to be a non-Hodgkin's large-cell lymphoma, which had shown a rapid response to chemotherapy without tumor recurrence in over 3 years since the diagnosis.
  • [MeSH-major] Device Removal. Endoscopy / methods. Jaundice / therapy. Lymphoma, Non-Hodgkin / therapy. Pancreatic Neoplasms / therapy. Stents

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  • (PMID = 12244508.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Metals
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30. Fraser CJ, Chan YF, Heath JA: Anaplastic large cell lymphoma of the pancreas: a pediatric case and literature review. J Pediatr Hematol Oncol; 2004 Dec;26(12):840-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic large cell lymphoma of the pancreas: a pediatric case and literature review.
  • Medical imaging subsequently demonstrated a 7 x 8 cm pancreatic mass.
  • Examination of a biopsy specimen obtained by open laparotomy revealed malignant lymphoma.
  • Histology, immunohistochemistry, and cytogenetics confirmed the diagnosis of ALK1-positive anaplastic large cell lymphoma.
  • He was treated with multiagent chemotherapy and remains in complete remission 12 months off treatment.
  • This is the first case of primary pancreatic ALK1-positive anaplastic large cell lymphoma described in a child and shows that aggressive surgical resection of pancreatic tumors is not always necessary to achieve a cure.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Abdominal Pain / etiology. Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Treatment Outcome

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  • (PMID = 15591909.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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