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Items 1 to 26 of about 26
1. Lee CC, Chen WM, Yen CC, Wu HD, Chen TH: Malignant lymphoma in an atomic-bomb survivor. J Chin Med Assoc; 2009 Jul;72(7):388-93

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  • [Title] Malignant lymphoma in an atomic-bomb survivor.
  • Spinal malignant lymphoma among these survivors is rare in established studies from Japan or the United States.
  • Both follicular lymphoma over the right elbow region and vertebral malignant lymphoma were found when she turned 81 years old.
  • However, thoracolumbar spine magnetic resonance imaging showed multiple infiltrative soft tissue masses involving vertebral bodies at the T10-11 level.
  • Computed tomography-guided biopsy further showed lymphocyte infiltration.
  • Fortunately, the neurological deficit was improved after chemotherapy.
  • The diagnosis of malignant lymphoma in atomic bomb survivors should be more careful and aggressive, even when their bone scan results show negative findings.
  • [MeSH-major] Epidural Neoplasms / etiology. Lymphoma, Follicular / etiology. Neoplasms, Radiation-Induced / etiology. Nuclear Warfare. Survivors

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  • (PMID = 19581148.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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2. Takeda M, Yamaguchi S, Eguchi K, Kajiume T, Nishimura S, Kobayashi M, Kurisu K: Spinal epidural granulocytic sarcoma in a child precedent to clinical manifestation of acute myeloid lymphoma: case report. Neurol Med Chir (Tokyo); 2009 May;49(5):221-4
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  • [Title] Spinal epidural granulocytic sarcoma in a child precedent to clinical manifestation of acute myeloid lymphoma: case report.
  • A 13-year-old boy presented with an epidural thoracic granulocytic sarcoma manifesting as rapidly progressive paraplegia preceding clinical manifestation of acute myeloid leukemia (AML).
  • Magnetic resonance imaging revealed a thoracic epidural tumor.
  • The initial histological diagnosis was malignant lymphoma.
  • The correct diagnosis of epidural granulocytic sarcoma and AML was established based on cell-surface markers and a chromosomal study of the bone marrow cells.
  • A combination of chemotherapy and bone marrow transfusion achieved complete remission of leukemia.
  • Granulocytic sarcoma should be considered in the differential diagnosis of an epidural mass in pediatric patients with or without acute leukemia.
  • Immediate diagnosis and appropriate treatment are recommended to prevent leukemic transformation.
  • [MeSH-major] Epidural Neoplasms / surgery. Leukemia, Myeloid, Acute / diagnosis. Sarcoma, Myeloid / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow Transplantation. Combined Modality Therapy. Exophthalmos / etiology. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Methylprednisolone / therapeutic use. Orbit / pathology. Paraplegia / etiology. Remission Induction. Temporal Lobe / pathology. Thoracic Vertebrae / surgery

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  • (PMID = 19465795.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] X4W7ZR7023 / Methylprednisolone
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3. Yu T, Wang ZY, Ma CC: [A case of peripheral T cell lymphomas-unspecified in vertebra canal]. Beijing Da Xue Xue Bao; 2007 Aug 18;39(4):343-5

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  • Peripheral T cell lymphomas-unspecified (PTCL-U) is an uncommon malignant tumor, accounting for 5%-7% of non-Hodgkin's lymphoma.
  • Clinical feature of a case of PTCL-U was investigated and the optimal treatment protocol was proposed.
  • Bilateral leg paralysis (Grade 0/5) with high muscle tension, overactive knee reflex, bilateral Babinski sign (+) were present.
  • Laminectomy and epidural tumor resection were performed immediately.
  • The patient received chemotherapy and his muscle strength was partly recovered in 4 months.
  • Regular radiotherapy and chemotherapy should be considered after operation.
  • However, the value of local chemotherapy need to be further investigated.
  • [MeSH-major] Epidural Neoplasms. Lymphoma, T-Cell, Peripheral

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  • (PMID = 17657255.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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4. Yamauchi K, Yasuda M: Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature. Cancer; 2002 Mar 15;94(6):1739-46
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  • [Title] Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature.
  • BACKGROUND: The purpose of this study was to reveal the clinical characteristics of nonleukemic granulocytic sarcoma (GS) and an association between the therapeutic regimens and the nonleukemic period.
  • These patients were divided into 3 groups by therapeutic regimens; Group I included 12 patients who received only biopsy or surgical resection of the tumor, Group II was 20 patients who received local irradiation for the tumor, and Group III consisted of 42 patients who received systemic chemotherapy.
  • In Group III, the period in the patients who were treated with chemotherapy given to ANLL was compared with that in the patients who received chemotherapy used for malignant lymphoproliferative disorders (MLPDs).
  • RESULTS: Thirty-five patients (47%) initially were misdiagnosed, and the disease was most often malignant lymphoma.
  • Preferential sites of GS were the small intestine, mediastinum, epidural site, uterus, and ovary, which often are difficult for the detection and diagnosis in addition to the skin and lymph nodes known commonly.
  • The aggressive chemotherapy given to ANLL led to a longer nonleukemic period than the chemotherapy used for MLPDs.
  • CONCLUSIONS: To reduce the risk of subsequent ANLL in patients with nonleukemic GS, it is important that accurate histologic diagnosis is established initially for GS and that all isolated cases of GS, even those that appear to be cured by resection or irradiation of the tumor, are treated with intensive chemotherapy similar to that used to treat ANLL during the nonleukemic period as soon as possible.
  • [MeSH-major] Leukemia, Myeloid, Acute / etiology. Sarcoma, Myeloid / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Humans. Lymphoma / diagnosis. Male. Middle Aged. Survival Analysis

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  • [Copyright] Copyright 2002 American Cancer Society.
  • (PMID = 11920536.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 59
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5. Higdon ML, Higdon JA: Treatment of oncologic emergencies. Am Fam Physician; 2006 Dec 1;74(11):1873-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of oncologic emergencies.
  • Most oncologic emergencies can be classified as metabolic, hematologic, structural, or side effects from chemotherapy agents.
  • Syndrome of inappropriate antidiuretic hormone should be suspected if a patient with cancer presents with normovolemic hyponatremia.
  • Febrile neutropenia is a hematologic emergency that usually requires inpatient therapy with broad-spectrum antibiotics, although outpatient therapy may be appropriate for low-risk patients.
  • Hyperviscosity syndrome usually is associated with Waldenström's macroglobulinemia, which is treated with plasmapheresis and chemotherapy.
  • Treatment options include chemotherapy, radiation, and intravenous stenting.
  • Epidural spinal cord compression can be treated with dexamethasone, radiation, or surgery.
  • Malignant pericardial effusion, which often is undiagnosed in cancer patients, can be treated with pericardiocentesis or a pericardial window procedure.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Neoplasms / complications
  • [MeSH-minor] Blood Viscosity. Humans. Hypercalcemia / etiology. Hypercalcemia / therapy. Immunoglobulins / blood. Inappropriate ADH Syndrome / etiology. Inappropriate ADH Syndrome / therapy. Neutropenia / etiology. Neutropenia / therapy. Spinal Cord Compression / etiology. Spinal Cord Compression / therapy. Tumor Lysis Syndrome / etiology. Tumor Lysis Syndrome / therapy

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  • (PMID = 17168344.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Immunoglobulins
  • [Number-of-references] 38
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6. Matsubara H, Watanabe K, Sakai H, Chang H, Fujino H, Higashi Y, Kobayashi M, Adachi S, Seto S, Nakahata T: Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy. Spine (Phila Pa 1976); 2004 Jan 1;29(1):E4-6
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  • [Title] Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy.
  • OBJECTIVE: The authors present a case of atypical Burkitt's lymphoma with multiple epidural involvements.
  • MATERIALS AND METHODS: Because the patient showed rapid neurologic deterioration, we started chemotherapy and high-dose steroids without laminectomy or radiotherapy immediately after a tumor biopsy from the left mandible.
  • RESULT: The combined therapies were very effective and his neurologic symptoms improved immediately.
  • The epidural involved masses disappeared in imaging studies after the first course of chemotherapy including methylprednisolone (20 mg/kg per day for 3 consecutive days and gradually tapered off over 2 weeks), vincristine (1.5 mg/m2 per day), cyclophosphamide (2 g/m2 per day for 2 days) and pirarubicin (40 mg/m2 per day).
  • After completing seven courses of chemotherapy, the patient is now fully ambulant.
  • CONCLUSION: Considering the severe late effects of laminectomy and radiotherapy, chemotherapy should be considered as a first choice of treatment for spinal cord compression caused by malignant lymphoma.
  • [MeSH-major] Burkitt Lymphoma / complications. Doxorubicin / analogs & derivatives. Epidural Neoplasms / complications. Paraplegia / drug therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child, Preschool. Cyclophosphamide / administration & dosage. Glucocorticoids / therapeutic use. Humans. Leg. Lumbar Vertebrae. Male. Methylprednisolone / therapeutic use. Pain / drug therapy. Pain / etiology. Time Factors. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 14699290.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; D58G680W0G / pirarubicin; X4W7ZR7023 / Methylprednisolone
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7. Masuda K, Mochida Y, Fujii J, Nakamura J, Sasaki A, Kita H, Mitsugi N, Saito T: Primary cervical epidural malignant lymphoma with rheumatoid arthritis: a case report. Mod Rheumatol; 2007;17(3):239-42
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  • [Title] Primary cervical epidural malignant lymphoma with rheumatoid arthritis: a case report.
  • We report a case of primary cervical epidural malignant lymphoma with rheumatoid arthritis.
  • The resected specimen showed proliferation of lymphoblastic cells diagnosed as malignant lymphoma.
  • Four series of chemotherapy were administered after surgery, and the patient recovered from paralysis.


8. Gale J, Mead GM, Simmonds PD: Management of spinal cord and cauda equina compression secondary to epidural metastatic disease in adults with malignant germ cell tumours. Clin Oncol (R Coll Radiol); 2002 Dec;14(6):481-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of spinal cord and cauda equina compression secondary to epidural metastatic disease in adults with malignant germ cell tumours.
  • AIM: To review the management and clinical outcome of 10 patients, presenting to a single centre with symptoms and signs of spinal cord or cauda equina compression secondary to epidural metastatic disease from a testicular germ cell cancer.
  • METHODS: Clinical data regarding presenting history, physical examination, staging investigations, treatment and clinical outcome were retrospectively obtained from patient records.
  • RESULTS: Eight patients exhibited neurological deficits at the time of initial presentation of germ cell cancer or as a first manifestation of relapse following dog leg irradiation.
  • Four of these cases were managed with chemotherapy alone, with excellent neurological recovery, whilst four underwent decompressive laminectomy--in three cases prior to referral and in one case after commencing chemotherapy.
  • Four required further chemotherapy (high dose in two cases).
  • Two patients presented with cord compression as a feature of disease relapse following chemotherapy, and were managed with radiotherapy alone in an attempt to achieve local disease control and limit neurological dysfunction.
  • CONCLUSION: Epidural spinal cord or cauda equina compression is a rare complication of metastatic germ cell cancer, which can be successfully managed in chemo-naive patients with good neurological outcome.
  • [MeSH-major] Bone Neoplasms / secondary. Cauda Equina / pathology. Neoplasms, Germ Cell and Embryonal / secondary. Peripheral Nervous System Neoplasms / secondary. Spinal Cord Compression / etiology. Spinal Cord Compression / therapy. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Physical Examination. Retrospective Studies. Treatment Outcome

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  • (PMID = 12512971.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Mukhopadhyay P, Gairola M, Sharma M, Thulkar S, Julka P, Rath G: Primary spinal epidural extraosseous Ewing's sarcoma: report of five cases and literature review. Australas Radiol; 2001 Aug;45(3):372-9
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  • [Title] Primary spinal epidural extraosseous Ewing's sarcoma: report of five cases and literature review.
  • Ewing's sarcoma is the most common malignant bone tumour occurring in children and adolescents and exists in two different clinicopathological entities: osseous Ewing's sarcoma (OES) and extraosseous Ewing's sarcoma (EES).
  • Five cases of primary epidural EES are described, which presented with non-specific symptoms leading to a long diagnostic delay.
  • All underwent surgical exploration with a laminectomy and partial resection followed by adjuvant radiotherapy to a dose of 46-50 Gy and chemotherapy with VAC (vincristine, adriamycin and cyclophosphamide) alternating with ICE (ifosphamide, cisplatin and etoposide) for at least six cycles.
  • Four of the five patients achieved a complete remission and are disease free at the time of writing this report.
  • Primary spinal epidural EES should be suspected whenever young patients present with back pain and/or radicular pain, have abnormal neurology and an extradural mass is demonstrated on MRI.
  • Surgical excision followed by adjuvant radiotherapy (50 Gy) and combination chemotherapy (VAC alternating with ICE) achieved local and systemic control in these patients.
  • A greater number of patients and longer follow up are required to evolve a generally accepted treatment policy for this aggressive but potentially curable malignancy.
  • [MeSH-major] Epidural Neoplasms / diagnosis. Sarcoma, Ewing / diagnosis
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 11531770.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 25
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10. Matinian NV, Saltanov AI, Illarionov IuV, Ordukhanian ZS: [Postoperative epidural bupivacaine infusion in pediatric oncology]. Anesteziol Reanimatol; 2006 Jan-Feb;(1):14-6
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  • [Title] [Postoperative epidural bupivacaine infusion in pediatric oncology].
  • The paper presents the results of use of continuous epidural bupivacaine infusion for postoperative anesthesia in 88 children operated on for malignant tumors.
  • Two groups of patients differing in the procedure of epidural bupivacaine infusion are compared.
  • [MeSH-major] Analgesia, Epidural / methods. Anesthetics, Local / therapeutic use. Bupivacaine / therapeutic use. Neoplasms / surgery. Pain, Postoperative / drug therapy
  • [MeSH-minor] Adolescent. Child. Drug Administration Schedule. Humans. Infusion Pumps. Treatment Outcome

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  • (PMID = 16613036.001).
  • [ISSN] 0201-7563
  • [Journal-full-title] Anesteziologiia i reanimatologiia
  • [ISO-abbreviation] Anesteziol Reanimatol
  • [Language] rus
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Anesthetics, Local; Y8335394RO / Bupivacaine
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11. Clancey JK: Spinal epidural lipomatosis: a case study. J Neurosci Nurs; 2004 Aug;36(4):208-9, 213
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  • [Title] Spinal epidural lipomatosis: a case study.
  • Spinal epidural lipomatosis (SEDL), an abnormal localized or tumor-like accumulation of fat in the epidural space, is an infrequent complication of chronic steroid usage and an uncommon cause of spinal cord compression.
  • A patient with a primary malignant brain tumor on chronic corticosteroids presented with a clinical picture of cord compression and was diagnosed with SEDL.
  • [MeSH-major] Adrenal Cortex Hormones / adverse effects. Epidural Neoplasms / chemically induced. Lipomatosis / chemically induced. Spinal Cord Compression / etiology. Thoracic Vertebrae
  • [MeSH-minor] Astrocytoma / complications. Astrocytoma / drug therapy. Brain Neoplasms / complications. Brain Neoplasms / drug therapy. Female. Humans. Middle Aged. Nursing Assessment

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  • (PMID = 15366546.001).
  • [ISSN] 0888-0395
  • [Journal-full-title] The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • [ISO-abbreviation] J Neurosci Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
  • [Number-of-references] 4
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12. Alimehmeti R, Locatelli M: Epidural B cell non-Hodgkin's lymphoma associated with chronic subdural hematoma. Surg Neurol; 2002 Mar;57(3):179-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidural B cell non-Hodgkin's lymphoma associated with chronic subdural hematoma.
  • BACKGROUND: Chronic subdural hematoma generally occurs in elderly patients, who are also prone to neoplasm.
  • However, the association of chronic subdural hematoma and intracranial neoplasm is rare.
  • CASE DESCRIPTION: An elderly woman harboring a chronic subdural hematoma underlying an epidural extension of a malignant B cell non-Hodgkin's lymphoma is reported.
  • CONCLUSIONS: In elderly patients harboring chronic subdural hematoma with mural isodensity on CT who have no history or an uncertain history of head trauma, one should consider the possibility of neoplasm, although it is rare.
  • Chronic subdural hematoma associated with epidural extension of B cell non-Hodgkin's lymphoma is exceptional.
  • Radiotherapy, alone or in combination with chemotherapy, should be considered after surgical removal.
  • [MeSH-major] Epidural Neoplasms / complications. Hematoma, Subdural, Chronic / etiology. Lymphoma, B-Cell / complications

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  • (PMID = 12009545.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Giese A, Kucinski T, Hagel C, Lohmann F: Intracranial tuberculomas mimicking a malignant disease in an immunocompetent patient. Acta Neurochir (Wien); 2003 Jun;145(6):513-7; discussion 517
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  • [Title] Intracranial tuberculomas mimicking a malignant disease in an immunocompetent patient.
  • A large left frontal epidural tuberculoma with transcalvarian extension was removed surgically and chemotherapy was initiated.
  • The patient remained on a chemotherapy with INH, RMP, and EMB and was followed clinically and with MRI scans for 24 months. Findings.
  • The clinical presentation and neuroimaging studies initially suggested malignant disease.
  • Based on the histological findings, chemotherapy for tuberculosis was initiated.
  • Because a tuberculoma is rarely suspected especially if there is atypical morphology, biopsy is required to establish the diagnosis and expedite specific treatment.
  • [MeSH-major] Brain Diseases / diagnosis. Brain Neoplasms / diagnosis. Tuberculoma, Intracranial / diagnosis
  • [MeSH-minor] Adolescent. Biopsy. Diagnosis, Differential. Drug Therapy, Combination. Female. Humans. Magnetic Resonance Imaging. Mycobacterium tuberculosis / isolation & purification

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  • [CommentIn] Acta Neurochir (Wien). 2004 Jan;146(1):89 [15386894.001]
  • (PMID = 12836079.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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14. Guzey FK, Emel E, Aycan A, Bas NS, Seyithanoglu MH, Ozkan N, Karabulut C: Pediatric vertebral and spinal epidural tumors: a retrospective review of twelve cases. Pediatr Neurosurg; 2008;44(1):14-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric vertebral and spinal epidural tumors: a retrospective review of twelve cases.
  • We aimed to report the clinical, radiological and pathological characteristics in a small series of pediatric vertebral and spinal epidural tumors and to discuss diagnostic and treatment difficulties.
  • MATERIALS AND METHODS: Twelve consecutive pediatric cases with vertebral or spinal epidural tumors were reviewed retrospectively.
  • There were histologically malignant lesions in 3 and benign lesions in 9 cases.
  • Three patients with malignant tumors were treated by radiotherapy and 2 by chemotherapy.
  • CONCLUSION: Children with vertebral tumors and spinal epidural tumors usually present with pain and neurological deficits or local findings, and there are some indications on plain radiographs.
  • [MeSH-major] Epidural Neoplasms / diagnosis. Epidural Neoplasms / therapy. Spinal Neoplasms / diagnosis. Spinal Neoplasms / therapy

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18097186.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 17
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15. Arias M, Pereiro I, Requena I, Ventura M, Iglesias C, Lema C: [Malignant prolactinoma with intra- and extracranial metastasis: clinico-radiologic study]. An Med Interna; 2000 Apr;17(4):192-4
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  • [Title] [Malignant prolactinoma with intra- and extracranial metastasis: clinico-radiologic study].
  • Malignant prolactinomas are very rare pituitary neoplasms which can be identified not from the hystopathologic nor neuroimaging aspects but only retrospectively from the presence of distant metastases.
  • Visual signs improved under bromocriptine treatment but after surgical and X-ray therapies patient developed paralysis of V and XII left cranial nerves and suffered from medulocerebelous angle, vertebrae, spinal epidural space, lung, liver, suprarenal and femoral metastases.
  • Patient died 3 years after the diagnosis time.
  • This is the first case of malignant prolactinoma described in the spanish literature and the more large one in number of metastatic localizations between the malignant prolactinomas from the literature.
  • These kind of neoplasms can be partially ameliorated under X-ray and bromocriptine treatment but there is not, by the moment, a curative chemotherapy.
  • [MeSH-major] Brain Neoplasms / secondary. Pituitary Neoplasms / pathology. Prolactinoma / secondary. Spinal Neoplasms / secondary

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  • (PMID = 10893770.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] SPAIN
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16. Yamada SM, Ikawa N, Toyonaga S, Nakabayashi H, Chang Park K, Shimizu K: Primary malignant B-cell-type dural lymphoma: Case report. Surg Neurol; 2006 Nov;66(5):539-43; discussion 543
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  • [Title] Primary malignant B-cell-type dural lymphoma: Case report.
  • BACKGROUND: The primary malignant dural lymphoma of B-cell type is rare.
  • Our review of the literature (24 cases) indicated that patients with this tumor had female predominance, immunocompetency, and longer survival compared with those with primary malignant intracerebral lymphomas.
  • Based on its clinicopathological features, this dural lymphoma may be classified differently from other types of malignant lymphomas in the central nervous system.
  • CASE DESCRIPTION: The authors report an example of a patient who had a favorable course of malignant dural lymphoma.
  • A 59-year-old woman presented with primary malignant dural lymphoma in the frontal area.
  • Histological diagnosis was a diffuse large B-cell-type lymphoma of intermediate malignancy, but MIB-1 index was extremely high.
  • Subtotal tumor removal was followed by 4 courses of chemotherapy.
  • A combination of subtotal resection and chemotherapy for a primary malignant dural lymphoma is an effective means to attempt cure of this tumor.
  • CONCLUSION: These rare tumors may be managed successfully by subtotal resection and postoperative treatment.
  • We believe that chemotherapy is the treatment of choice after subtotal resection of malignant dural lymphomas, as experienced in our case.
  • [MeSH-major] Dura Mater / pathology. Lymphoma, B-Cell / diagnosis. Meningeal Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cerebral Veins / pathology. Cerebral Veins / radiography. Craniotomy. Decompression, Surgical. Epidural Space / pathology. Epidural Space / radiography. Epidural Space / surgery. Female. Frontal Lobe / pathology. Humans. Lymphocytes / pathology. Magnetic Resonance Imaging. Middle Aged. Radionuclide Imaging. Thallium Radioisotopes. Treatment Outcome

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  • (PMID = 17084207.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Thallium Radioisotopes
  • [Number-of-references] 23
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17. Kedlaya D, Reynolds L, Waldman S: Epidural and intrathecal analgesia for cancer pain. Best Pract Res Clin Anaesthesiol; 2002 Dec;16(4):651-65
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  • [Title] Epidural and intrathecal analgesia for cancer pain.
  • The three-step analgesic ladder approach developed by the World Health Organization works well in treating the vast majority (70-90%) of patients suffering from pain related to cancer.
  • In those patients who do not get pain relief by this three-step approach, intraspinal agents can be a fourth step in managing pain of malignant origin.
  • Although morphine is the only opioid approved by the US Food and Drug Administration for intraspinal use, many different opioid analgesics are used intraspinally, including hydromorphone, fentanyl, sufentanil, meperidine and methadone in the treatment of cancer pain.
  • Many non-opioid agents have also been used intraspinally either alone or in combination with opioids in the treatment of intractable cancer pain.
  • [MeSH-major] Analgesia, Epidural / methods. Anesthetics, Local / administration & dosage. Neoplasms / complications. Pain / drug therapy. Pain / etiology

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  • (PMID = 12516896.001).
  • [ISSN] 1521-6896
  • [Journal-full-title] Best practice & research. Clinical anaesthesiology
  • [ISO-abbreviation] Best Pract Res Clin Anaesthesiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adrenergic alpha-Agonists; 0 / Analgesics, Opioid; 0 / Anesthetics, Local; 0 / Calcium Channel Blockers; 0 / Excitatory Amino Acid Antagonists
  • [Number-of-references] 83
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18. Edwards JG, Martin-Ucar AE, Stewart DJ, Waller DA: Right extrapleural pneumonectomy for malignant mesothelioma via median sternotomy or thoracotomy? Short- and long-term results. Eur J Cardiothorac Surg; 2007 May;31(5):759-64
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  • [Title] Right extrapleural pneumonectomy for malignant mesothelioma via median sternotomy or thoracotomy? Short- and long-term results.
  • OBJECTIVE: To examine the short- and long-term results of right extrapleural pneumonectomy (EPP) for malignant pleural mesothelioma (MM) via median sternotomy or thoracotomy.
  • Operation time was faster with median sternotomy than right thoracotomy (p=0.008).
  • Right thoracotomy was associated with higher epidural infusion volume in the first 3 days than median sternotomy (p<0.001).
  • Planned neoadjuvant or adjuvant chemotherapy was more common following median sternotomy than right thoracotomy (p=0.01).
  • [MeSH-major] Mesothelioma / surgery. Pleural Neoplasms / surgery. Pneumonectomy / methods
  • [MeSH-minor] Analgesia, Epidural / methods. Antineoplastic Agents / therapeutic use. Case-Control Studies. Cisplatin / therapeutic use. Humans. Kaplan-Meier Estimate. Neoadjuvant Therapy / methods. Neoplasm Staging. Postoperative Period. Retrospective Studies. Sternum / surgery. Thoracotomy / methods. Time Factors. Treatment Outcome

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  • (PMID = 17350854.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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19. Kurosawa H, Matsunaga T, Shimaoka H, Sato Y, Kuwashima S, Sugita K, Hagane K, Eguchi M: Burkitt lymphoma associated with large gastric folds, pancreatic involvement, and biliary tract obstruction. J Pediatr Hematol Oncol; 2002 May;24(4):310-2
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  • Large gastric folds in adults are seen in many benign and malignant conditions, but they are rare in children with malignant diseases such as non-Hodgkin lymphoma.
  • Magnetic resonance imaging showed a typical diffuse infiltrating type of pancreatic lymphoma.
  • Because complete bilateral lower limb paralysis developed as a result of the epidural soft tissue mass, laminectomy and tumor resection were performed and a diagnosis of disseminated Burkitt lymphoma was established.
  • After completing 6 months of chemotherapy, the patient has been disease-free without neurologic complications for 2.5 years.
  • [MeSH-major] Burkitt Lymphoma / diagnosis. Cholestasis / diagnosis. Gastric Mucosa / pathology. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 11972102.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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20. Yano H, Nakano Y, Tono T, Ohnishi T, Iwazawa T, Kimura Y, Kanoh T, Monden T: Hand-assisted laparoscopic splenectomy for splenic tumors. Dig Surg; 2004;21(3):215-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The feasibility of hand-assisted laparoscopic splenectomy (HALS) for splenic tumors including benign or malignant neoplasms and the associated clinical outcome of the patients remain unclear.
  • RESULTS: Ten patients with splenic tumors consisted of 5 with benign tumors and 5 with malignant tumors.
  • Mean operative time was 170 min (range 100-310 min).
  • Postoperative chemotherapy was given to 4 patients with malignant tumors including metastatic carcinomas and malignant lymphomas.
  • Mean time to first flatus, mean time to first walking, mean time to resumption of oral intake, mean length of hospital stay, and mean duration of epidural analgesia were 1.8, 1, 1.5, 10.8 and 3.1 days, respectively.
  • CONCLUSION: HALS may be a good indication for malignant tumors as well as benign tumors of the spleen.
  • [MeSH-major] Laparoscopy / methods. Splenectomy / methods. Splenic Neoplasms / surgery
  • [MeSH-minor] Blood Loss, Surgical. Feasibility Studies. Female. Follow-Up Studies. Humans. Intraoperative Complications / epidemiology. Length of Stay / statistics & numerical data. Male. Middle Aged. Postoperative Complications / epidemiology. Retrospective Studies. Time Factors

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  • [Copyright] Copyright 2004 S. Karger AG, Basel
  • (PMID = 15237254.001).
  • [ISSN] 0253-4886
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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21. Nishihara M, Kudo H, Mizuno I, Taomoto K, Kohmura E: [An adult case of precursor B cell lymphoblastic lymphoma extending from right neck to upper cervical spinal region]. No Shinkei Geka; 2005 Nov;33(11):1107-11
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  • The radiological examinations including MRI showed the tumor extending from right neck to the epidural space from medulla to the C4 level.
  • The pathological diagnosis of biopsy specimens was malignant lymphoma.
  • This type of lymphoma is highly aggressive.
  • The intensive chemotherapy regimen such as hyper-CVAD was superior to the lymphoma-like regimens.
  • Measurement of IL-2 receptor and biopsy with flow cytometry were necessary to work out the treatment strategy of the spinal malignant lymphoma.
  • In this case, the complete response (CR) of the tumor was achieved with hyper-CVAD regimen and radiation therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, B-Cell / pathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Cervical Vertebrae. Cyclophosphamide / administration & dosage. Dexamethasone / administration & dosage. Doxorubicin / administration & dosage. Gadolinium DTPA. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neck. Precancerous Conditions / drug therapy. Precancerous Conditions / pathology. Vincristine / administration & dosage

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  • (PMID = 16277225.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; K2I13DR72L / Gadolinium DTPA; CVAD protocol
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22. Ravnik J, Potrc S, Kavalar R, Ravnik M, Zakotnik B, Bunc G: Dumbbell synovial sarcoma of the thoracolumbar spine: a case report. Spine (Phila Pa 1976); 2009 May 1;34(10):E363-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Surgical procedures, adjuvant treatment, and outcome were discussed.
  • The rationale for 2-step surgical procedure and adjuvant therapy is discussed in light of the clinical picture, preoperative imaging and extension of the disease.
  • Histologic examination revealed highly malignant synovial sarcoma.
  • Patient was treated with chemotherapy and radiotherapy after surgery.
  • RESULTS: Patient was in remission and symptom free for 1 year after surgery; he then developed a local recurrence and died soon afterwards.
  • CONCLUSION: A good treatment result was achieved initially.
  • A combined approach in cases like this is warranted, with as radical surgery as possible in order to avoid local recurrence, a common cause of treatment failure in sarcomas.
  • [MeSH-major] Lumbar Vertebrae / pathology. Neurosurgical Procedures / methods. Retroperitoneal Neoplasms / secondary. Sarcoma, Synovial / secondary. Spinal Neoplasms / pathology. Thoracic Vertebrae / pathology
  • [MeSH-minor] Adult. Epidural Space / pathology. Epidural Space / radiography. Epidural Space / surgery. Fatal Outcome. Humans. Laminectomy. Laparotomy. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Paraparesis / etiology. Retroperitoneal Space / pathology. Retroperitoneal Space / radiography. Retroperitoneal Space / surgery. Spinal Canal / pathology. Spinal Canal / radiography. Spinal Canal / surgery. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19404166.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Sekiguchi N, Watanabe T, Kobayashi Y, Inokuchi C, Kim SW, Yokota Y, Tanimoto K, Matsuno Y, Tobinai K: The application of molecular analyses for primary granulocytic sarcoma with a specific chromosomal translocation. Int J Hematol; 2005 Oct;82(3):210-4
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  • Otherwise, primary GS is often misdiagnosed as a malignant lymphoma or other malignancies.
  • Here we describe a 28-year-old woman with primary GS manifesting as an epidural tumor in the sacral region accompanied by meningeal dissemination.
  • Fluorescence in situ hybridization analysis detected the AML1/MTG8 fusion gene in neoplastic cells obtained from her cerebrospinal fluid specimen and the epidural mass.
  • Systemic chemotherapy with high-dose cytarabine followed by local radiotherapy was performed, and the patient clinically achieved a complete response.
  • These molecular analyses provide a precise method of diagnosis, especially with respect to the French-American-British AML classification, according to the characteristic karyotypic alterations, and a patient consequently can quickly be given appropriate systemic chemotherapy as induction therapy.
  • [MeSH-major] Chromosomes, Human, Pair 21 / genetics. Chromosomes, Human, Pair 8 / genetics. Core Binding Factor Alpha 2 Subunit / genetics. Oncogene Proteins, Fusion / genetics. Sarcoma, Myeloid / genetics. Spinal Neoplasms / genetics. Translocation, Genetic
  • [MeSH-minor] Adult. Antimetabolites, Antineoplastic / administration & dosage. Combined Modality Therapy. Cytarabine / administration & dosage. DNA Mutational Analysis. Female. Hemibody Irradiation. Humans

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  • (PMID = 16207593.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / AML1-ETO fusion protein, human; 0 / Antimetabolites, Antineoplastic; 0 / Core Binding Factor Alpha 2 Subunit; 0 / Oncogene Proteins, Fusion; 04079A1RDZ / Cytarabine
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24. Kvale PA, Simoff M, Prakash UB, American College of Chest Physicians: Lung cancer. Palliative care. Chest; 2003 Jan;123(1 Suppl):284S-311S
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lung cancer. Palliative care.
  • The majority of patients who acquire lung cancer will have troublesome symptoms at some time during the course of their disease.
  • Some of the symptoms are common to many types of cancers, while others are more often encountered with lung cancer than other primary sites.
  • This document will address the management of these symptoms, and it will also address the palliation of specific problems that are commonly seen in lung cancer: metastases to the brain, spinal cord, and bones; hemoptysis; tracheoesophageal fistula; and obstruction of the superior vena cava.
  • [MeSH-major] Lung Neoplasms / therapy. Pain Management. Palliative Care
  • [MeSH-minor] Analgesics / therapeutic use. Bone Neoplasms / secondary. Bone Neoplasms / therapy. Brain Neoplasms / secondary. Brain Neoplasms / therapy. Bronchoscopy / methods. Cough / drug therapy. Cough / etiology. Dyspnea / drug therapy. Dyspnea / etiology. Epidural Neoplasms / secondary. Epidural Neoplasms / therapy. Hemoptysis / etiology. Hemoptysis / therapy. Humans. Pain / etiology. Pleural Effusion, Malignant / complications. Pleural Effusion, Malignant / therapy. Radiotherapy / methods. Spinal Cord Compression / etiology. Spinal Cord Compression / therapy. Superior Vena Cava Syndrome / etiology. Superior Vena Cava Syndrome / therapy. Tracheoesophageal Fistula / etiology. Tracheoesophageal Fistula / therapy

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  • (PMID = 12527586.001).
  • [ISSN] 0012-3692
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Guideline; Journal Article; Practice Guideline; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics
  • [Number-of-references] 216
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25. Schoeggl A, Reddy M, Matula C: Neurological outcome following laminectomy in spinal metastases. Spinal Cord; 2002 Jul;40(7):363-6
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  • OBJECTIVES: Patients suffering from malignant tumour disease and metastases to the spine develop a variety of clinical complaints including radicular symptoms and/or spinal cord compression syndromes.
  • Palliative decompressive laminectomy with total or partial tumour resection is an acknowledged method of treatment, despite controversy.
  • METHOD: Patients suffering from metastases with predominant infiltration of the dorsal epidural parts, or patients who could not be operated on via an anterior approach, were included.
  • The median survival time was 6.5 months.
  • Post-operatively, 38%, and after 2 months 46% of the patients, developed continence disorders.
  • A significant reduction in analgesic medication was also observed in the post-operative period.
  • CONCLUSION: In our series, palliative laminectomy with total or subtotal tumour reduction in patients with malignant spinal metastatic disease resulted in amelioration of motor function, pain and continence and therefore improved the patients' quality of life.
  • The improvement in quality of life shows that this method is a valuable option in neurosurgical therapy, except for cases with pre-operative paraplegia.
  • [MeSH-major] Laminectomy. Outcome Assessment (Health Care). Palliative Care. Spinal Cord Compression / surgery. Spinal Neoplasms / surgery
  • [MeSH-minor] Analgesics / therapeutic use. Austria. Drug Utilization / statistics & numerical data. Fecal Incontinence / etiology. Follow-Up Studies. Humans. Motor Activity. Pain / drug therapy. Pain / etiology. Paraparesis / etiology. Postoperative Period. Quality of Life. Retrospective Studies. Survival Rate. Treatment Outcome. Urinary Incontinence / etiology

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  • (PMID = 12080464.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics
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26. Donnelly S, Davis MP, Walsh D, Naughton M, World Health Organization: Morphine in cancer pain management: a practical guide. Support Care Cancer; 2002 Jan;10(1):13-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphine in cancer pain management: a practical guide.
  • Morphine is the most practical and versatile analgesic for the relief of severe pain associated with advanced cancer.
  • The age of the patient and multiple medications will alter morphine pharmacokinetics.
  • ), epidural and intrathecal.
  • Recent experience confirms benefits of topical morphine for cutaneous pain associated with benign or malignant ulcers.
  • [MeSH-major] Analgesics, Opioid / pharmacology. Analgesics, Opioid / therapeutic use. Morphine / pharmacology. Morphine / therapeutic use. Neoplasms / complications. Neoplasms / drug therapy. Pain / drug therapy. Pain / etiology
  • [MeSH-minor] Age Factors. Dose-Response Relationship, Drug. Drug Administration Routes. Female. Humans. Male. Sex Factors. Treatment Outcome. United States

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  • (PMID = 11777184.001).
  • [ISSN] 0941-4355
  • [Journal-full-title] Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
  • [ISO-abbreviation] Support Care Cancer
  • [Language] eng
  • [Publication-type] Guideline; Journal Article; Practice Guideline; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 76I7G6D29C / Morphine
  • [Number-of-references] 302
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