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1. Dhiwakar M, Clement WA, Supriya M, McKerrow W: Antibiotics to reduce post-tonsillectomy morbidity. Cochrane Database Syst Rev; 2010;(7):CD005607
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Postoperative bacterial infection of the tonsillar fossa has been proposed as an important factor causing pain and associated morbidity, and some studies have found a reduction in morbid outcomes following the administration of perioperative antibiotics.
  • Secondary outcomes were fever, time taken to resume normal diet and activities and adverse events.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Tonsillectomy / adverse effects
  • [MeSH-minor] Adult. Analgesics. Antibiotic Prophylaxis. Bacterial Infections / drug therapy. Child. Convalescence. Fever / drug therapy. Humans. Pain, Postoperative / drug therapy. Postoperative Hemorrhage / drug therapy. Postoperative Hemorrhage / etiology. Randomized Controlled Trials as Topic

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  • [UpdateIn] Cochrane Database Syst Rev. 2012;12:CD005607 [23235625.001]
  • [UpdateOf] Cochrane Database Syst Rev. 2008;(2):CD005607 [18425926.001]
  • (PMID = 20614441.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics; 0 / Anti-Bacterial Agents
  • [Number-of-references] 54
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2. Lukan N: [Fusafungine after tonsillectomy]. Laryngorhinootologie; 2002 Jun;81(6):426-9
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  • Except of standard postoperative therapy 34 patients received fusafungine in spray 4 times daily and 34 patients served as a control.
  • Pain score in the morning and in the evening, consumption of analgesics and visual estimation of wound healing in the tonsillar fossa was evaluated.
  • CONCLUSION: Fusafungine in spray improves quality of life after the tonsillectomy and so completes the spectrum of adjuvant postoperative local treatment possibilities.
  • [MeSH-major] Aerosols / administration & dosage. Anti-Bacterial Agents / administration & dosage. Pain, Postoperative / drug therapy. Postoperative Care. Tonsillectomy
  • [MeSH-minor] Administration, Topical. Adolescent. Adult. Analgesics / administration & dosage. Female. Fusarium. Humans. Male. Middle Aged. Pain Measurement. Treatment Outcome. Wound Healing / drug effects

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  • (PMID = 12063630.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Aerosols; 0 / Analgesics; 0 / Anti-Bacterial Agents; 65DD690W0C / fusafungin
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3. Lacosta JL, Calzada G, Infante JC, Ramalle-Gómara E: [Cancer of the tonsillar region. Retrospective study and review of the literature]. Acta Otorrinolaringol Esp; 2001 Jan-Feb;52(1):33-7
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  • [Title] [Cancer of the tonsillar region. Retrospective study and review of the literature].
  • [Transliterated title] Cáncer de la región amigdalina. Estudio retrospectivo y revisión de la literatura.
  • It has been carried out a retrospective analysis of 34 patients suffering from carcinoma epidermoid of the tonsillar fossa being treated with two different therapies from 1989 to 1996.
  • Eleven of them were treated with chemotherapy and radiotherapy.
  • On multivariate analysis, age (p = 0.28) and modality of treatment (p = 0.80) were not significant effect on survival.
  • Advanced stages (III-IV) showed 3.4 times much more risk of death than early stages (I-II) (p = 0.11).
  • [MeSH-major] Carcinoma, Squamous Cell. Tonsillar Neoplasms

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  • (PMID = 11269877.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 23
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4. Egeli E, Harputluoglu U, Oghan F, Demiraran Y, Guclu E, Ozturk O: Does topical lidocaine with adrenaline have an effect on morbidity in pediatric tonsillectomy? Int J Pediatr Otorhinolaryngol; 2005 Jun;69(6):811-5
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  • One group received lidocaine with adrenaline soaked swabs packed in their tonsillar fossae while the control group received saline-soaked swabs.
  • Chi-square and two-tailed unpaired Student's t-tests were used to compare the two independent groups. p<0.05 was accepted as statistically significant.
  • CONCLUSION: We suggest that application of topical lidocaine with adrenaline seems to be a safe and easy medication for local anesthetic use.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Double-Blind Method. Drug Therapy, Combination. Female. Humans. Male. Prospective Studies. Time Factors. Treatment Failure

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  • (PMID = 15885334.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anesthetics, Local; 0 / Vasoconstrictor Agents; 98PI200987 / Lidocaine; YKH834O4BH / Epinephrine
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5. Giannoni C, White S, Enneking FK: Does dexamethasone with preemptive analgesia improve pediatric tonsillectomy pain? Otolaryngol Head Neck Surg; 2002 Mar;126(3):307-15
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  • All patients received tonsillar fossa injections of ropivacaine plus clonidine before tonsil excision.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Dexamethasone / therapeutic use. Pain, Postoperative / drug therapy. Preanesthetic Medication. Tonsillectomy / adverse effects
  • [MeSH-minor] Adolescent. Amides. Analysis of Variance. Child. Child, Preschool. Clonidine. Double-Blind Method. Drug Therapy, Combination. Female. Humans. Male. Pain Measurement. Quality of Life

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  • (PMID = 11956540.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Amides; 0 / Anti-Inflammatory Agents, Non-Steroidal; 7IO5LYA57N / ropivacaine; 7S5I7G3JQL / Dexamethasone; MN3L5RMN02 / Clonidine
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6. Dhiwakar M, Clement WA, Supriya M, McKerrow WS: Antibiotics to reduce post-tonsillectomy morbidity. Cochrane Database Syst Rev; 2008;(2):CD005607
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Postoperative bacterial infection of the tonsillar fossa has been proposed as an important factor causing pain and associated morbidity, and some studies have found a reduction in morbid outcomes following the administration of perioperative antibiotics.
  • Secondary outcomes were fever, time taken to resume normal diet and activities and adverse events.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Tonsillectomy / adverse effects
  • [MeSH-minor] Adult. Analgesics / administration & dosage. Antibiotic Prophylaxis. Bacterial Infections / drug therapy. Child. Convalescence. Fever / drug therapy. Humans. Pain, Postoperative / drug therapy. Postoperative Hemorrhage / drug therapy. Postoperative Hemorrhage / etiology. Randomized Controlled Trials as Topic

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  • [UpdateIn] Cochrane Database Syst Rev. 2010;(7):CD005607 [20614441.001]
  • (PMID = 18425926.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics; 0 / Anti-Bacterial Agents
  • [Number-of-references] 50
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7. Moshref M, Mashhadi-Abbass F, Sargolzaei S, Nafarzadeh S: Extramedullary plasmacytoma of the gingiva. Arch Iran Med; 2007 Jan;10(1):91-3
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  • Extramedullary plasmacytoma is defined as neoplastic proliferation of plasma cells in soft tissue.
  • Approximately, 90% of extramedullary plasmacytomas are found in the head and neck region commonly affecting the nasal cavity, paranasal sinuses, tonsillar fossa, and oral cavity.
  • Radiotherapy is the common modality of treatment with or without adjuvant chemotherapy.
  • [MeSH-minor] Biopsy. Bone Marrow Cells / pathology. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 17198461.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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8. Holsinger FC, McWhorter AJ, Ménard M, Garcia D, Laccourreye O: Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: I. Technique, complications, and functional results. Arch Otolaryngol Head Neck Surg; 2005 Jul;131(7):583-91
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  • [Title] Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: I. Technique, complications, and functional results.
  • PATIENTS: A total of 191 patients who underwent TLO for selected invasive squamous cell carcinoma of the tonsil and/or tonsillar fossa.
  • INTERVENTIONS: Ten patients had received preoperative radiation therapy.
  • Induction chemotherapy was used in 153 patients (80.3%).
  • Postoperative radiation therapy was administered to 52 patients (28.7%).
  • CONCLUSIONS: From a functional standpoint, the TLO is a safe surgical approach for treating selected carcinoma of the tonsillar fossa.
  • It is a reliable technique that should be considered for treatment of appropriate squamous cell carcinoma of the tonsil.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Oropharynx / surgery. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intubation, Gastrointestinal. Length of Stay. Male. Middle Aged. Otorhinolaryngologic Surgical Procedures / methods. Postoperative Complications. Retrospective Studies. Tracheostomy. Treatment Outcome

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  • (PMID = 16027280.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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9. Mau T, Oh Y, Bucci MK, Eisele DW: Management of cervical metastases in advanced squamous cell carcinoma of the tonsillar fossa following radiotherapy. Arch Otolaryngol Head Neck Surg; 2005 Jul;131(7):600-4
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  • [Title] Management of cervical metastases in advanced squamous cell carcinoma of the tonsillar fossa following radiotherapy.
  • OBJECTIVE: To assess the value of planned neck dissection in patients with a complete response to definitive radiotherapy for squamous cell carcinoma of the tonsillar fossa with advanced nodal disease.
  • PATIENTS: A consecutive series of 36 patients with squamous cell carcinoma of the tonsillar fossa with N2 or N3 nodal disease treated with primary radiation therapy with or without concurrent chemotherapy between January 1, 1992, and April 1, 2003, at the University of California, San Francisco, Comprehensive Cancer Center.
  • Of the 15 patients with a complete response, only 2 (13%) later developed regional recurrences, 1 of which was an isolated recurrence in the neck.
  • CONCLUSIONS: The rate of regional recurrence after a complete response to radiation therapy with or without concurrent chemotherapy for tonsillar squamous cell carcinoma with advanced cervical metastases is low.
  • Our results support close surveillance of the neck in those who have achieved a complete response after radiation therapy with or without chemotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / therapy. Head and Neck Neoplasms / secondary. Head and Neck Neoplasms / therapy. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Survival Rate. Treatment Outcome

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  • (PMID = 16027282.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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10. Moore EJ, Henstrom DK, Olsen KD, Kasperbauer JL, McGree ME: Transoral resection of tonsillar squamous cell carcinoma. Laryngoscope; 2009 Mar;119(3):508-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transoral resection of tonsillar squamous cell carcinoma.
  • OBJECTIVES: The tonsillar fossa is the most common subsite of the oropharynx to be afflicted with squamous cell carcinoma (SCCA).
  • Accepted treatments include any combination of surgery, radiotherapy, and chemotherapy.
  • We review the oncologic and functional outcomes of patients with tonsillar carcinoma who underwent transoral tumor resection and neck dissection with or without postoperative radiotherapy or chemoradiotherapy.
  • METHODS: From 1996 through January 2005, 102 patients with tonsillar SCCA underwent transoral resection.
  • Immediate and long-term speech and swallowing function and treatment-related morbidity were analyzed.
  • CONCLUSIONS: Transoral resection of tonsillar SCCA with or without postoperative adjuvant therapy provided excellent locoregional control and minimized treatment-related morbidity.
  • We believe that transoral resection is the optimal treatment for patients with oropharyngeal SCCA.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tonsillar Neoplasms / surgery. Tonsillectomy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Mouth. Neoplasm Staging. Retrospective Studies. Treatment Outcome


11. Canbay O, Celebi N, Uzun S, Sahin A, Celiker V, Aypar U: Topical ketamine and morphine for post-tonsillectomy pain. Eur J Anaesthesiol; 2008 Apr;25(4):287-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of the current study was to evaluate the potential effects of topically administered ketamine and morphine by an oral rinse into the tonsillar fossae.
  • Study drugs were administered to both tonsillar fossae for 5 min.
  • Morphine and ketamine groups had longer effective analgesia time than the morphine + ketamine and control groups.
  • [MeSH-major] Analgesics / administration & dosage. Analgesics, Opioid / therapeutic use. Ketamine / administration & dosage. Morphine / administration & dosage. Pain, Postoperative / drug therapy
  • [MeSH-minor] Child. Child, Preschool. Drug Therapy, Combination. Female. Humans. Male. Mouthwashes. Pain Measurement. Saliva, Artificial. Time Factors. Tonsillectomy / adverse effects

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  • (PMID = 18186954.001).
  • [ISSN] 1365-2346
  • [Journal-full-title] European journal of anaesthesiology
  • [ISO-abbreviation] Eur J Anaesthesiol
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics; 0 / Analgesics, Opioid; 0 / Mouthwashes; 0 / Saliva, Artificial; 690G0D6V8H / Ketamine; 76I7G6D29C / Morphine
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