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1. Mrad K, Driss M, Abdelmoula S, Sassi S, Hechiche M, Ben Romdhane K: Primary broad ligament cystadenocarcinoma with mucinous component: a case report with immunohistochemical study. Arch Pathol Lab Med; 2005 Feb;129(2):244-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary broad ligament cystadenocarcinoma with mucinous component: a case report with immunohistochemical study.
  • Primary cystadenocarcinoma that arises in the broad ligament is extremely rare, especially when it is mucinous.
  • We report the case of a 59-year-old woman with a cystic mass of the right broad ligament who underwent a complete excision of the mass (7 x 7 x 3 cm) with hysterectomy, right salpingo-oophorectomy, omentectomy, appendicectomy, and peritoneal biopsies.
  • Pathologic examination showed a low-grade cystadenocarcinoma with a mucinous component limited to the broad ligament.
  • Despite the chemotherapy (cisplatinum and cyclophosphamide) performed, early tumor recurrence occurred after approximately 6 months.
  • [MeSH-major] Broad Ligament / pathology. Cystadenocarcinoma, Mucinous / diagnosis. Immunohistochemistry / methods. Urogenital Neoplasms / diagnosis

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  • (PMID = 15679432.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Mucin-1; 68238-35-7 / Keratins
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2. Rajan DK, Soulen MC, Clark TW, Baum RA, Haskal ZJ, Shlansky-Goldberg RD, Freiman DB: Sarcomas metastatic to the liver: response and survival after cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol chemoembolization. J Vasc Interv Radiol; 2001 Feb;12(2):187-93
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  • Primary tumors included 11 gastrointestinal leiomyosarcomas, two splenic angiosarcomas, one leiomyosarcoma of the broad ligament, one leiomyosarcoma of the inferior vena cava, and one malignant fibrous histiocytoma of the colon.
  • Chemoembolization with cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol particles was performed 1-5 times at approximately monthly intervals (mean, 2.8).
  • Pre- and posttreatment cross-sectional imaging was performed 1 month after completion of treatment and then every 3 months.
  • RESULTS: Two patients (13%) exhibited partial morphologic response, 11 patients (69%) were morphologically stable, and three (19%) demonstrated progression of disease 30 days after completion of treatment.
  • Among the 13 responders, two underwent partial hepatectomy after initial treatment.
  • Seven developed intrahepatic progression at a mean of 10 months and a median time of 8 months.
  • The remaining four patients had no documented intrahepatic progression at the time of last imaging follow-up.
  • Nine patients developed extrahepatic progression at a mean time of 6.3 months and a median time of 6 months, of whom four underwent additional surgical resection.
  • Response to therapy was based on time of first intervention.
  • Cumulative survival from time of diagnosis with use of Kaplan-Meier analysis was 81% at 1 year, 54% at 2 years, and 40% at 3 years.
  • Median survival time was 20 months.
  • Cumulative survival from initial chemoembolization was 67% at 1 year, 50% at 2 years, and 40% at 3 years, with a median survival time of 13 months.
  • CONCLUSION: Durable tumor response with chemoembolization is possible in this form of metastatic disease, which is highly resistant to systemic chemotherapy.
  • [MeSH-major] Chemoembolization, Therapeutic. Leiomyosarcoma / secondary. Leiomyosarcoma / therapy. Liver Neoplasms / secondary. Liver Neoplasms / therapy
  • [MeSH-minor] Cisplatin / administration & dosage. Disease Progression. Doxorubicin / administration & dosage. Ethiodized Oil / administration & dosage. Female. Follow-Up Studies. Humans. Male. Mitomycin / administration & dosage. Polyvinyl Alcohol / administration & dosage. Survival Rate. Time Factors

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  • (PMID = 11265882.001).
  • [ISSN] 1051-0443
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 8008-53-5 / Ethiodized Oil; 80168379AG / Doxorubicin; 9002-89-5 / Polyvinyl Alcohol; Q20Q21Q62J / Cisplatin
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3. Redman R, Wilkinson EJ, Massoll NA: Uterine-like mass with features of an extrauterine adenomyoma presenting 22 years after total abdominal hysterectomy-bilateral salpingo-oophorectomy: a case report and review of the literature. Arch Pathol Lab Med; 2005 Aug;129(8):1041-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium.
  • These tumors typically originate within the uterus.
  • The mass was pear-shaped with uterine-type smooth muscle and a cavity lined by functional endometrial glands and stroma.
  • Three involved the ovary, while one was located adjacent to the broad ligament with normal pelvic organs.
  • Although none of these other uterus-like masses were described as adenomyomas with uterine-like features, the histologic findings are strikingly similar.
  • An understanding of the müllerian system suggests that either an embryologic malformation or a differential multipotentiality existing in the subcoelomic tissues in response to hormonal stimulation results in a supernumerary müllerian structure like a uterus, as observed in this case.
  • The presence of endometrial glands and stroma in the mass confirms that the tissues in this mass are hormonally responsive.
  • It is most likely that this uterine-like mass arose from the tissues of the secondary müllerian system in response to estrogenic stimulation.
  • [MeSH-major] Adenomyoma / pathology. Gynecologic Surgical Procedures. Neoplasms, Hormone-Dependent / diagnosis. Uterine Neoplasms / pathology. Uterus / pathology
  • [MeSH-minor] Estrogen Replacement Therapy / adverse effects. Fallopian Tubes / surgery. Female. Humans. Hysterectomy. Middle Aged. Mullerian Ducts / drug effects. Mullerian Ducts / pathology. Ovariectomy

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  • (PMID = 16048397.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Kolusari A, Ugurluer G, Kosem M, Kurdoglu M, Yildizhan R, Adali E: Leiomyosarcoma of the broad ligament: a case report and review of the literature. Eur J Gynaecol Oncol; 2009;30(3):332-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyosarcoma of the broad ligament: a case report and review of the literature.
  • Leiomyosarcoma of the broad ligament is a rare tumour, since only 15 cases have been reported thus far in the English literature.
  • We describe the case of a 35-year-old patient with primary leiomyosarcoma of the broad ligament.
  • The histologic diagnosis and management of this rapidly progressive and highly malignant tumour are also discussed.
  • The tumor had high mitotic activity and more than ten mitotic figures were found for ten high-power fields.
  • The treatment consisted of total abdominal hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection.
  • The patient received pelvic radiotherapy and chemotherapy considering the high grade of malignancy.
  • [MeSH-major] Broad Ligament. Genital Neoplasms, Female / diagnosis. Leiomyosarcoma / diagnosis
  • [MeSH-minor] Adnexal Diseases / diagnosis. Adnexal Diseases / pathology. Adult. Female. Humans

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  • (PMID = 19697635.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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5. Karaca M, Sevinc A, Aydin A, Gocmen A, Buyukberber S, Camci C, Sari I: Female adnexal tumor of probable Wolffian origin diagnosed during the staging evaluation of extranodal diffuse large B-cell lymphoma. Leuk Lymphoma; 2005 Jun;46(6):929-33
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  • [Title] Female adnexal tumor of probable Wolffian origin diagnosed during the staging evaluation of extranodal diffuse large B-cell lymphoma.
  • Female adnexal tumor of probable Wolffian origin (FATPWO) is a rare neoplasm arising within the leaves of broad ligament or hanging from it or a fallopian tube.
  • A 55-year-old female patient with the diagnosis of non-Hodgkin lymphoma is presented.
  • The staging procedure revealed a pelvic mass that was not regressed by chemotherapy.
  • According to our knowledge, this is the first case of FATPWO coexisting with extranodal diffuse large B-cell lymphoma in the English-language literature.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Neoplasms, Adnexal and Skin Appendage / diagnosis. Wolffian Ducts / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cytoplasm / metabolism. Female. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Staging. Stomach Neoplasms / complications. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy. Treatment Outcome

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  • (PMID = 16019541.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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6. Numnum TM, Leath CA 3rd, Straughn JM Jr, Conner MG, Barnes MN 3rd: Occult choriocarcinoma discovered by positron emission tomography/computed tomography imaging following a successful pregnancy. Gynecol Oncol; 2005 May;97(2):713-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Occult choriocarcinoma discovered by positron emission tomography/computed tomography imaging following a successful pregnancy.
  • BACKGROUND: Positron emission tomography (PET) is commonly used to detect occult or recurrent malignancy, including tumors of the female genital tract.
  • She had a history of molar pregnancy and persistent GTD requiring multi-agent chemotherapy.
  • Metastatic evaluation with computed tomography and magnetic resonance imaging showed no evidence of GTD.
  • A positron emission tomography/computed tomography (PET/CT) scan revealed a focus of metabolic activity in the left pelvis.
  • The patient underwent an exploratory laparotomy that revealed metastatic choriocarcinoma in the left broad ligament.
  • [MeSH-minor] Adult. Female. Humans. Pelvic Neoplasms / radionuclide imaging. Pelvic Neoplasms / secondary. Positron-Emission Tomography. Pregnancy. Pregnancy Outcome. Tomography, X-Ray Computed

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  • (PMID = 15863190.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Clarke BA, Rahimi K, Chetty R: Leiomyosarcoma of the broad ligament with osteoclast-like giant cells and rhabdoid cells. Int J Gynecol Pathol; 2010 Sep;29(5):432-7
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  • [Title] Leiomyosarcoma of the broad ligament with osteoclast-like giant cells and rhabdoid cells.
  • In this report we document an unusual co-mingling of rhabdoid and osteoclast like giant cells in a leiomyosarcoma arising from the broad ligament.
  • The tumor now showed a prominent population of both osteoclast-like giant cells and rhabdoid cells.
  • Interestingly, the immunophenotype of the tumor had also changed with complete loss of desmin, caldesmon and only focal expression of smooth muscle actin.
  • This tumor was characterized by rapid clinical progression despite extensive surgery and chemotherapy.
  • These two cells types have individually been implicated as harbingers of a poor prognosis in leiomyosarcomas.
  • Their prominence in the recurrent tumor and the loss of muscle marker expression are in keeping with biologic progression.
  • [MeSH-major] Broad Ligament / pathology. Giant Cells / pathology. Leiomyosarcoma / pathology. Osteoclasts / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 20736768.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Shone N, Duggan MA, Ghatage P: Granulosa cell tumour of the broad ligament. Pathology; 2003 Jun;35(3):265-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granulosa cell tumour of the broad ligament.
  • [MeSH-major] Broad Ligament / pathology. Genital Neoplasms, Female / pathology. Granulosa Cell Tumor / secondary. Peritoneal Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Female. Humans. Immunohistochemistry. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Palliative Care

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  • (PMID = 14506976.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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9. Duhan N, Singh S, Kadian YS, Duhan U, Rajotia N, Sangwan N: Primary leiomyosarcoma of broad ligament: case report and review of literature. Arch Gynecol Obstet; 2009 May;279(5):705-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary leiomyosarcoma of broad ligament: case report and review of literature.
  • INTRODUCTION: Primary leiomyosarcoma of the broad ligament (LBL) is a very rare and highly malignant gynecological tumor.
  • MATERIALS AND METHODS: A 45 year old hysterectomized woman with this rare tumor is presented.
  • Treatment consisted of resection of the tumor along with omental and peritoneal sampling and adjuvant chemotherapy.
  • CONCLUSION: Complete surgery along with adjuvant chemotherapy or radiation and a close follow up for recurrence are advocated to optimize disease free survival.
  • [MeSH-major] Broad Ligament / pathology. Leiomyosarcoma / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Dactinomycin / administration & dosage. Female. Gynecologic Surgical Procedures. Humans. Middle Aged. Vincristine / administration & dosage

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  • (PMID = 18777035.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide
  • [Number-of-references] 27
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10. Murialdo R, Usset A, Guido T, Carli F, Boccardo F, Amoroso D: Leiomyosarcoma of the broad ligament: a case report and review of literature. Int J Gynecol Cancer; 2005 Nov-Dec;15(6):1226-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyosarcoma of the broad ligament: a case report and review of literature.
  • Leiomyosarcoma of the broad ligament is a rare tumor, since only 12 cases have been reported so far in the literature.
  • A 53-year-old patient was diagnosed with leiomyosarcoma of the broad ligament at the Department of Gynecology Oncology of the National Cancer Research Institute in Genoa.
  • The tumor had low mitotic activity and less than ten mitotic figures were found for ten high-power fields.
  • The treatment consisted of total abdominal hysterectomy and bilateral salpingo-oophorectomy with bilateral ureteral neoanastomosis and omentectomy.
  • The patient has not received either radiotherapy or chemotherapy, considering the low grade of malignancy, but she is only followed up on an outpatient basis.
  • It is concluded that low-grade leiomyosarcoma of the broad ligament should be treated only with surgery.
  • [MeSH-minor] Broad Ligament. Female. Gynecologic Surgical Procedures. Humans. Middle Aged

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  • (PMID = 16343220.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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11. Nagar YS, Singh S, Sawlani V, Pal L, Dimri K, Lal P: Primary papillary serous cystadenocarcinoma of broad ligament. Australas Radiol; 2005 Apr;49(2):160-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary papillary serous cystadenocarcinoma of broad ligament.
  • A rare case of an advanced primary broad ligament carcinoma is discussed, with a review of the literature regarding its incidence, presentation and management.
  • This patient showed a complete response to adjuvant cisplatin-based chemotherapy following panhysterectomy and is presently without any evidence of disease, 15 months after completion of her treatment.
  • [MeSH-major] Broad Ligament. Cystadenocarcinoma, Papillary / surgery. Genital Neoplasms, Female / surgery
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Cisplatin / therapeutic use. Diagnosis, Differential. Female. Humans. Hysterectomy. Middle Aged. Photomicrography. Tomography, X-Ray Computed

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  • (PMID = 15845057.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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12. Itani Y, Itoh K, Adachi S, Koyama M, Kimura T, Chin R, Takemura T: Malignant epithelial tumor of unknown origin of the broad ligament. Arch Gynecol Obstet; 2002 Dec;267(2):113-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant epithelial tumor of unknown origin of the broad ligament.
  • Malignant epithelial tumor of the broad ligament is rare and to our knowledge only 17 cases have been reported.
  • We report a 54-year-old Japanese woman in whom transvaginal sonography (TVS) and magnetic resonance imaging (MRI) showed a left adnexal tumor.
  • Preoperatively, we diagnosed this tumor was a left ovarian malignant tumor though, it was confirmed a the 47x57 mm tumor in the left broad ligament at laparotomy.
  • Histologically most of the tumor showed serous papillary adenocarcinoma with changes similar to poorly differentiated carcinoma and as seen in transitional cell carcinoma on hematoxylin-eosin staining.
  • After three courses of platinum based adjuvant chemotherapy, the patient is alive with no recurrence at 18 months postoperatively.
  • [MeSH-major] Broad Ligament. Cystadenocarcinoma, Papillary / pathology. Genital Neoplasms, Female / pathology

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  • (PMID = 12439561.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 9
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13. Corusic A, Barisic D, Lovric H, Despot A, Planinic P: Successful laparoscopic bipolar coagulation of a large arteriovenous malformation due to invasive trophoblastic disease: a case report. J Minim Invasive Gynecol; 2009 May-Jun;16(3):368-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful laparoscopic bipolar coagulation of a large arteriovenous malformation due to invasive trophoblastic disease: a case report.
  • We report the case of an acquired large arteriovenous malformation due to invasive gestational trophoblastic tumor that was treated successfully with laparoscopic surgery.
  • After 4 cycles of methotrexate chemotherapy, a vascular tangle (volume, 28 cm(3)) was noted that emerged from the right uterine horn, invading the broad ligament adjacent to the uterine artery.
  • Doppler ultrasonography along with magnetic resonance arteriography confirmed the diagnosis.
  • Laparoscopy was performed, and bipolar coagulation of the ovarian and uterine artery feeding branches was achieved after surgical resection of the tumor.
  • The patient underwent chemotherapy, and at 2-month follow-up was cured and has since had regular menstrual cycles.
  • [MeSH-minor] Adult. Antimetabolites, Antineoplastic / therapeutic use. Female. Humans. Hysterotomy. Methotrexate / therapeutic use. Ovary / blood supply. Pregnancy. Uterus / blood supply

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  • (PMID = 19423071.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; YL5FZ2Y5U1 / Methotrexate
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14. Ahuja S, Gaunt M, Crawford R: The use of Palma's procedure in the salvage therapy for a leiomyosarcoma of the right pelvic sidewall: an intraoperative multidisciplinary approach. Int J Gynecol Cancer; 2005 Jan-Feb;15(1):175-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The use of Palma's procedure in the salvage therapy for a leiomyosarcoma of the right pelvic sidewall: an intraoperative multidisciplinary approach.
  • Leiomyosarcomas of the ovary and broad ligament are relatively rare.
  • Less than 50 cases of primary ovarian and broad ligament leiomyosarcomas have been reported.
  • It is difficult to determine the exact role of surgery, chemotherapy, and radiotherapy in the management of these tumors.
  • So far, no cases of ovarian or broad ligament leiomyosarcomas have been reported where primary surgery for the sarcoma had to be combined with a Palma's procedure.
  • Resection of the pelvic mass was carried out and a Palma's procedure was performed by the vascular surgeon.
  • Chemotherapy was given postoperatively.
  • [MeSH-minor] Combined Modality Therapy. Female. Gynecologic Surgical Procedures. Humans. Middle Aged. Patient Care Team. Pelvis. Salvage Therapy

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  • (PMID = 15670315.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Steed H, Oza A, Chapman WB, Yaron M, De Petrillo D: Female adnexal tumor of probable wolffian origin: a clinicopathological case report and a possible new treatment. Int J Gynecol Cancer; 2004 May-Jun;14(3):546-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Female adnexal tumor of probable wolffian origin: a clinicopathological case report and a possible new treatment.
  • Female adnexal tumors of probable wolffian origin (FATWOs) are rare tumors arising in the broad ligament from the remnants of the mesonephric duct.
  • A 15-year-old girl who presented with a painful pelvic mass underwent a laparotomy with tumor resection.
  • The tumor recurred within 2 years and was treated with multiple chemotherapy regimens, including a platinum-based drug, and surgery for progressive disease.
  • The tumor was positive for c-kit oncogene (CD 117).
  • Gleevac therapy, a tyrosine kinase inhibitor, was prescribed, and she developed severe persistent lower abdominal pain 2 months later.
  • Pathology showed evidence of tumor necrosis, suggesting a possible beneficial effect, and she was recommenced on Gleevac in an effort to prevent recurrences.
  • She is currently asymptomatic, without evidence of disease 10 months after surgery, continuing on Gleevac therapy.
  • There is limited knowledge about the optimal treatment for this neoplasm.
  • Our patient's favorable response to Gleevac therapy supports the concept of targeted molecular therapy in patients with c-kit-positive FATWO tumors.
  • [MeSH-major] Neoplasm Recurrence, Local / diagnosis. Peritoneal Neoplasms / diagnosis. Wolffian Ducts
  • [MeSH-minor] Abdominal Pain / etiology. Adolescent. Combined Modality Therapy. Diagnosis, Differential. Enzyme Inhibitors / therapeutic use. Female. Humans. Protein-Tyrosine Kinases / antagonists & inhibitors

  • Genetic Alliance. consumer health - Wolffian tumor.
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  • (PMID = 15228432.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 2.7.10.1 / Protein-Tyrosine Kinases
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