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1. Cresswell J, Scheitlin W, Gozen A, Lenz E, Teber D, Rassweiler J: Laparoscopic retroperitoneal lymph node dissection combined with adjuvant chemotherapy for pathological stage II disease in nonseminomatous germ cell tumours: a 15-year experience. BJU Int; 2008 Sep;102(7):844-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic retroperitoneal lymph node dissection combined with adjuvant chemotherapy for pathological stage II disease in nonseminomatous germ cell tumours: a 15-year experience.
  • OBJECTIVE: To present our 15-year experience of laparoscopic retroperitoneal lymph node dissection (LRPLND) combined with adjuvant chemotherapy (after RPLND) for patients with nonseminomatous germ cell tumour and positive nodes (pN+), evaluating the morbidity and long-term oncological outcome.
  • PATIENTS AND METHODS: Data for 87 patients with clinical stage I GCT were collected prospectively from 1992 to 2007.
  • Primary diagnostic LRPLND was performed for pathological staging using a modified-template dissection.
  • Patients with lymph node involvement had adjuvant chemotherapy, with two cycles of bleomycin, etoposide and cisplatin.
  • RESULTS: The mean (range) operative duration was 177 (68-360) min, and the hospital stay 6 (4-18) days.
  • Positive nodes were identified in 24% of patients, who subsequently had adjuvant chemotherapy.
  • After a mean (range) follow-up of 84 (1-186) months, distant relapse occurred in 9% of patients with pathological stage I (no adjuvant chemotherapy), including three patients with pulmonary metastases, two with retroperitoneal recurrence (outside the template field), two biochemical recurrences (alpha-fetoprotein elevated) and one port-site metastasis.
  • No patients with pN+ disease relapsed.
  • There were complications after surgery in 9% of patients, i.e. one pulmonary embolus, one lymphocoele, temporary ureteric stenting in two, ureteric stenosis requiring surgical repair in three and retrograde ejaculation in one patient.
  • All patients remain disease-free.
  • CONCLUSIONS: After gaining experience, LRPLND has comparable operative times to contemporary open series, and low morbidity.
  • No patients with pN+ had a recurrence, showing the efficacy of adjuvant chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Germinoma / therapy. Lymph Node Excision / methods. Retroperitoneal Neoplasms / therapy. Testicular Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Chemotherapy, Adjuvant. Humans. Laparoscopy. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Orchiectomy. Prospective Studies. Treatment Outcome

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  • (PMID = 18537954.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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2. Madanur MA, Battula N, Azam MO, Heaton N, Rela M: Chylous ascites after pancreatico-duodenectomy cholangiocarcinoma xenografts in nude mice. Hepatobiliary Pancreat Dis Int; 2007 Aug;6(4):416-9
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  • BACKGROUND: Chylous ascites (CA) following pancreatico-duodenectomy (PD) is a rare complication secondary to disruption of the lymphatics during extended retroperitoneal lymph node dissection.
  • The majority of cases do not develop CA, possibly due to patency of the proximal thoracic duct and good collaterals.
  • CA may be due to a consequence of occult obstruction of the proximal thoracic duct by malignant infiltration or tumor embolus.
  • Two patients developed loco-regional recurrences at a median follow up of 8 months (range 6-10 months).
  • And the other was currently disease free at a 10-month follow up.
  • CONCLUSIONS: CA as an uncommon postoperative complication requires frequent paracentesis, prolonged hospital stay, and delayed adjuvant chemotherapy.
  • [MeSH-minor] Aged. Female. Humans. Lymph Node Excision. Male. Middle Aged. Neoplasm Transplantation. Peritoneum / metabolism. Postoperative Complications. Retrospective Studies

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  • (PMID = 17690041.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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3. Tanoue Y, Tanaka N, Suzuki Y, Hata S, Yokota A: A case report of endocrine cell carcinoma in the sigmoid colon with inferior mesenteric vein tumor embolism. World J Gastroenterol; 2009 Jan 14;15(2):248-51
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  • [Title] A case report of endocrine cell carcinoma in the sigmoid colon with inferior mesenteric vein tumor embolism.
  • We report a case of endocrine cell carcinoma in the sigmoid colon with inferior mesenteric vein (IMV) tumor embolism.
  • We performed colonoscopy, computed tomography and positron emission tomography, which disclosed sigmoid colon cancer with IMV tumor embolism.
  • She underwent sigmoidectomy and lymph node dissection.
  • The tumor was diagnosed as endocrine cell carcinoma (type 4, pSS, med, INFalpha, v3, n1, stage IIIb).
  • She was treated with chemotherapy of cisplatin (CDDP) + irinotecan (CPT11).
  • This case highlights the aggressiveness of endocrine cell carcinoma with tumor embolism, and it is essential to establish an accurate diagnosis and effective treatment.

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  • [Cites] Br J Cancer. 1999 Dec;81(8):1351-5 [10604732.001]
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  • (PMID = 19132778.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2653316
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4. Kosugi M, Ono T, Yamaguchi H, Sato N, Dan K, Tanaka K, Takano T: Successful treatment of primary cardiac lymphoma and pulmonary tumor embolism with chemotherapy. Int J Cardiol; 2006 Jul 28;111(1):172-3
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  • [Title] Successful treatment of primary cardiac lymphoma and pulmonary tumor embolism with chemotherapy.
  • A 72-year-old man with a large mass in the right atrium and the pulmonary embolism by chest computed tomography was diagnosed as the primary cardiac B-cell lymphoma (PCL) with pulmonary tumor embolism and pericardial effusion.
  • Upon completion of initial chemotherapy, the mass was markedly reduced, and the pulmonary embolism disappeared on magnetic resonance imaging.
  • This rarely diagnosed entity is treatable with chemotherapy for both PCL and pulmonary embolism.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Heart Neoplasms / drug therapy. Lymphoma, B-Cell / drug therapy. Neoplastic Cells, Circulating. Pulmonary Embolism / drug therapy. Pulmonary Embolism / etiology
  • [MeSH-minor] Aged. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Humans. Male. Prednisone / therapeutic use. Remission Induction. Vincristine / therapeutic use

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  • (PMID = 16129500.001).
  • [ISSN] 0167-5273
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Ireland
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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5. Klepacka T, Woźniak W, Liebhart M, Michalak E, Kuczabski M, Rychłowska M: [Local recurrences after salvage operations in the therapy of osteogenic sarcoma cases - an analysis of adverse effects based on studied cases]. Med Wieku Rozwoj; 2000 Apr-Jun;4(2 Suppl 2):67-76
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  • [Title] [Local recurrences after salvage operations in the therapy of osteogenic sarcoma cases - an analysis of adverse effects based on studied cases].
  • Therapeutic approach in osteogenic sarcoma until 1982 was connected mainly with surgery.
  • Introduction of chemotherapy to the therapeutic protocols of osteogenic sarcoma improved the 5 years survival of patients with osteogenic sarcoma from 20% to 60-70%.
  • The approach to surgical treatment was also changed.
  • The principle of this treatment is usually to perform an operation to spare the limb with an intraoperative frozen section examination of bone marrow.
  • In our Institute during the last 14 years about 300 cases were diagnosed, out of which about 200 were treated surgically, among these about 50% underwent treatment by salvage operations.
  • Only in 7 cases local recurrences of disease were confirmed.
  • Five of these cases were tumours of distal metaphysis of the femur, one case of proximal metaphysis of the tibia and one case of proximal metaphysis of the humeral bone.
  • The sex range M/F was: 5/2, the average age of onset about 14 years.
  • Various factors playing a role in therapeutic adversities were analysed.
  • Among these were: radical surgery, grade of differentiation of the tumour, histological subtype, soft tissue infiltration, reaction to preoperative therapy and the type of chemotherapy.
  • The conducted analysis indicates the role played by sparing surgery in adversities in therapy (3 cases).
  • Attention was also given to the distinct tendency of osteogenic sarcoma to produce vascular embolism which is a source of haematogenously spreading metastases.
  • In 7 cases vascular tumour embolism caused the appaerance of metastatic focuses adjacent to the primary tumour.
  • A certain role in therapeutic adverities is played by the lack of response to preoperative chemotherapy (4/7 cases).
  • [MeSH-major] Bone Neoplasms / surgery. Neoplasm Recurrence, Local. Osteosarcoma / surgery. Salvage Therapy / adverse effects
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Child. Female. Humans. Male. Risk Factors

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  • (PMID = 11178330.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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6. Dzieciuchowicz ŁS, Słowinski M, Brzeziński JJ, Kycler W: Tumor embolus due to uterine cancer. Med Sci Monit; 2009 Oct;15(10):CS155-157
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  • [Title] Tumor embolus due to uterine cancer.
  • The purpose of this paper is to report a case of tumor embolus of a brachial artery.
  • CASE REPORT: A 64-year-old woman was referred for vascular surgery due to acute right upper-limb ischemia.
  • Because of an atypical appearance resembling fatty tissue, the embolic material was sent for microscopic examination that revealed carcinoma cells.
  • Chest X-ray and CT-guided biopsy showed previously unknown pulmonary metastasis.
  • In spite of chemotherapy, the patient died one year later due to progression of the neoplastic disease.
  • The literature and common features of tumor embolus are reviewed.
  • This may be the first reported case of tumor peripheral arterial embolus caused by endometrial adenocarcinoma CONCLUSIONS: Although tumor emboli are a rarely described cause of acute limb ischemia, pathological examination of the embolic material seems to be indicated, especially in patients with an unknown source of emboli and in every case of an atypical appearance.
  • [MeSH-major] Embolism / complications. Embolism / pathology. Uterine Neoplasms / complications. Uterine Neoplasms / pathology

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  • (PMID = 19789516.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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7. Shamberger RC, Ritchey ML, Haase GM, Bergemann TL, Loechelt-Yoshioka T, Breslow NE, Green DM: Intravascular extension of Wilms tumor. Ann Surg; 2001 Jul;234(1):116-21
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  • [Title] Intravascular extension of Wilms tumor.
  • OBJECTIVE: To define the incidence and manifestations of and optimal therapy for children with intravascular extension of Wilms tumor.
  • METHODS: Children on a collaborative study of Wilms tumor who had intravascular extension into the inferior vena cava (IVC) or atrium were identified.
  • RESULTS: One hundred sixty-five of 2,731 patients had intravascular extension of Wilms tumor.
  • Sixty-nine had received preoperative therapy (55 with IVC extension and 14 with atrial extension) for a median of 8 weeks.
  • Complications during preoperative chemotherapy were seen in five patients (tumor embolism and tumor progression in one each, and three with adult respiratory distress syndrome, one of which was fatal).
  • The intravascular extension of the tumor regressed in 39 of 49 children with comparable pre- and posttherapy radiographic studies, including 7 of 12 in whom the tumor regressed from an atrial location, thus obviating the need for cardiopulmonary bypass.
  • Surgical complications occurred in 36.7% of the children in the atrial group and 17.2% in the IVC group.
  • The frequency of surgical complications was 26% in the primary resection group versus 13.2% in children with preoperative therapy.
  • When all the complications of therapy were considered, including those that occurred during the interval of preoperative chemotherapy (one of the five also had a surgical complication), the incidence of complications among those receiving preoperative therapy was not statistically different from the incidence among those who underwent primary resection.
  • The difference in 3-year relapse-free survival (76.9% for 165 patients with intravascular extension, 80.3% for 1,622 patients with no extension) was not statistically significant whether or not it was adjusted for stage and histology.
  • CONCLUSIONS: Preoperative treatment of these children may facilitate resection by decreasing the extent of the tumor thrombus, but the overall frequency of complications is similar in both groups.

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  • (PMID = 11420491.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA-42326
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1421956
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8. Hoshimoto S, Hagiuda J, Igarashi N, Matsui H, Koyama Y, Miyakita M, Takanosu S: [A case of advanced gastric cancer with a tumor embolus in the portal vein successfully treated with TS-1 and CDDP]. Gan To Kagaku Ryoho; 2004 Jul;31(7):1079-81
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  • [Title] [A case of advanced gastric cancer with a tumor embolus in the portal vein successfully treated with TS-1 and CDDP].
  • A 71-year-old man was admitted to our hospital in February 2002 with a diagnosis of advanced gastric cancer with a tumor embolus in the portal vein.
  • TS-1 (120 mg/day) was administered orally daily for 21 days, and CDDP (90 mg/day) was infused intravenously on day 8.
  • After 1 course of this regimen, medication was discontinued in accordance with the patient's request.
  • The patient was readmitted with a history of tarry stools in July 2003.
  • Despite no cancer treatment for almost 1.5 years, the primary lesion and the metastatic lymph nodes had decreased significantly in size and the tumor embolus in the portal vein had disappeared completely on the CT scan.
  • He was therefore treated with TS-1 alone (120 mg/day) under a 4-weeks-on and 2-weeks-off regimen.
  • After 1 course of TS-1 administered alone, the primary lesion showed a further significant decrease in size as viewed by GI endoscopy, and biopsies did not reveal any evidence of malignancy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplastic Cells, Circulating / pathology. Portal Vein / pathology. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Aged. Cisplatin / administration & dosage. Drug Administration Schedule. Drug Combinations. Humans. Infusions, Intravenous. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Oxonic Acid / administration & dosage. Pyridines / administration & dosage. Tegafur / administration & dosage

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  • (PMID = 15272589.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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9. Ishiko T, Doi K, Beppu T, Hirota M, Ogawa M: [A case report of advanced huge hepatocellular carcinoma (H.C.C.) accompanied by tumor embolism to the inferior caval vein (Vv3) that was treated with surgical extended right lobectomy after multimodal therapy]. Gan To Kagaku Ryoho; 2002 Nov;29(12):2416-20
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  • [Title] [A case report of advanced huge hepatocellular carcinoma (H.C.C.) accompanied by tumor embolism to the inferior caval vein (Vv3) that was treated with surgical extended right lobectomy after multimodal therapy].
  • We performed multimodal therapy for a huge hepatocellular carcinoma with tumor embolism (Vv3), for which excision was judged impossible.
  • After treatment, a hepatectomy to the primary lesion was finally carried out and long-term survival was achieved.
  • A 52-years-old man with right lateroabdominal pain had a huge occupied hepatocellular carcinoma that was detected in October 2000.
  • A tumor embolism, which invaded the inferior vena cava, was also seen.
  • A percutaneous transhepatic portal embolism (PTPE) was carried out against the right portal vein to increase in the left lobe capacity.
  • The chemo-radiotherapy (36 Gy to the right hepatic vein and systemic administration of CDDP) and transcatheter arterial chemoembolization were added to the feeding arteries of the hepatic tumor.
  • When a decrease in the postcaval vein tumor embolism was observed, the extended right hepatic lobectomy was performed.
  • The postoperative course was good, and the patient was discharged from the hospital on postoperative day 41.
  • Though lung metastasis and new lesions in left lobe were seen in a recurrence, two years and ten months since the start of the systemic chemotherapy.
  • This case suggested that even if a huge liver cancer with vascular invasion is judged impossible to excise, multimodal therapy with the aim of surgical treatment helps retain the possibility to later chose hepatectomy for the primary lesion and improve prognosis.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Hepatectomy. Liver Neoplasms / therapy. Neoplastic Cells, Circulating / pathology
  • [MeSH-minor] Cisplatin / administration & dosage. Combined Modality Therapy. Embolization, Therapeutic. Humans. Male. Middle Aged. Vena Cava, Inferior / pathology

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  • (PMID = 12484089.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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10. Mehta RS, Schubbert T, Marshall J, Carpenter PM: Rational and successful use of carboplatin and albumin-bound paclitaxel in a patient with recurrent metaplastic carcinoma who presented with multi-organ tumor emboli. Clin Breast Cancer; 2009 Feb;9(1):56-9
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  • [Title] Rational and successful use of carboplatin and albumin-bound paclitaxel in a patient with recurrent metaplastic carcinoma who presented with multi-organ tumor emboli.
  • We demonstrate successful treatment of recurrent chondroid-metaplastic breast cancer.
  • Breast cancer recurrence was diagnosed when a patient with a history of metaplastic breast cancer presented with recurrent acute strokes.
  • A diagnosis of tumor embolism was suspected when a chest radiograph performed as part of a work-up for stroke demonstrated several lung nodules, with 1 lung nodule invading the pulmonary vein and extending into the left atrium-the source of tumor emboli.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / drug therapy. Metaplasia / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Albumin-Bound Paclitaxel. Albumins / administration & dosage. Carboplatin / administration & dosage. Female. Humans. Middle Aged. Paclitaxel / administration & dosage. Treatment Outcome

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  • (PMID = 19299243.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA062203
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumin-Bound Paclitaxel; 0 / Albumins; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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11. Zeni PT Jr, Blank BG, Peeler DW: Use of rheolytic thrombectomy in treatment of acute massive pulmonary embolism. J Vasc Interv Radiol; 2003 Dec;14(12):1511-5
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  • [Title] Use of rheolytic thrombectomy in treatment of acute massive pulmonary embolism.
  • PURPOSE: The 6-F Xpeedior (AngioJet; Possis Medical, Minneapolis, MN) rheolytic thrombectomy catheter (RTC) uses high velocity saline jets for thrombus aspiration, maceration, and evacuation, through the Bernoulli principle.
  • The purpose of this study was to evaluate the efficacy of thrombus removal using the RTC in patients with acute massive pulmonary embolism (PE).
  • MATERIALS AND METHODS: Seventeen patients (mean age, 51.7 + 16.6 years; range, 30-86 years; 9 men, 8 women) with massive PE initially diagnosed by computed tomography (CT) or VQ scan and confirmed by pulmonary angiography were treated with the RTC.
  • Six patients had contraindications to thrombolytic therapy.
  • One patient presented with renal cell carcinoma and tumor embolus as suspected cause of PE.
  • Treatment resulted in immediate angiographic improvement and initial relief of PE symptoms (improvement in dyspnea and oxygen saturation) in 16 of 17 patients.
  • One patient developed heart block during the procedure, and further treatment with the RTC was discontinued.
  • Bradycardia occurred in one patient (managed with lidocaine).
  • After thrombectomy, 10 patients received adjunctive reteplase thrombolysis for treatment of residual thrombus, and 12 received inferior vena cava (IVC) filters.
  • In the patient with renal cell carcinoma, histopathologic analysis of the evacuated material confirmed tumor origin of the embolism.
  • There were two deaths, both within 24 hours of treatment and secondary to PE.
  • One death occurred in a patient who had only minimal thrombus removal after treatment with the RTC and no thrombolysis.
  • The remaining 15 patients showed continued improvement in PE symptoms and were eventually discharged from the hospital with mean length of stay 10.3 + 6.5 days (range, 5-30 days).
  • Further evaluation in a larger cohort of patients is warranted to assess whether this treatment may offer an alternative or complement to thrombolysis or surgical thrombectomy.
  • [MeSH-major] Fibrinolytic Agents / therapeutic use. Pulmonary Embolism / drug therapy. Pulmonary Embolism / surgery. Thrombectomy
  • [MeSH-minor] Acute Disease. Adult. Aged. Aged, 80 and over. Catheterization / adverse effects. Catheterization / instrumentation. Catheterization / methods. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • [CommentIn] J Vasc Interv Radiol. 2004 Sep;15(9):1024; author reply 1024 [15470786.001]
  • (PMID = 14654484.001).
  • [ISSN] 1051-0443
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrinolytic Agents
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12. Tsuchiya T, Hiramatsu K, Tanaka H, Machiki Y, Sakuragawa T, Otsuji H, Hara T, Kimura A, Yoshida K, Hosoya J, Kojima T, Kato K: [A Case of gastric endocrine cell carcinoma successfully treated by FU plus irinotecan(CPT-11)adjuvant therapy against recurrent metastases]. Gan To Kagaku Ryoho; 2009 Dec;36(13):2641-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A Case of gastric endocrine cell carcinoma successfully treated by FU plus irinotecan(CPT-11)adjuvant therapy against recurrent metastases].
  • A case of gastric endocrine cell carcinoma successfully treated by FU (5-FU/UFT) +irinotecan (CPT-11) adjuvant therapy against recurrent metastases is reported with some discussion.
  • A 69-year-old man was admitted to our hospital with severe anemia.
  • He was diagnosed with advanced gastric cancer, T3N1H0P0M0, Stage IIIa.
  • Total gastrectomy with pancreato-splenectomy with D2 lymph node dissection was done for curative resection.
  • Seven months after operation, recurrent liver metastases with tumor embolism of the portal vein were revealed by enhanced CT examination.
  • FU (5-FU/UFT) +CPT-11 was done as the first-line adjuvant chemotherapy.
  • Metastatic lesion of the liver and portal vein tumor embolism was decreased.
  • Tumor marker CA19-9 level was also decreased and within normal limits.
  • This therapy was evaluated as a partial response (PR) in twelve months and the patient died three years and eight months after operation.
  • Gastric endocrine cell carcinoma is known as a potentially highly malignant tumor.
  • But in our case FU+CPT-11 controlled growth of the recurrent tumor.
  • Based on this finding, we recommend adjuvant chemotherapy by FU+CPT-11 for gastric endocrine cell carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Stomach Neoplasms / therapy
  • [MeSH-minor] Aged. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Chemotherapy, Adjuvant. Fluorouracil / administration & dosage. Gastrectomy. Humans. Lymph Node Excision. Male. Neoplasm Metastasis. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 20009471.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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13. Tucakovic M, Bascom R, Bascom PB: Pulmonary medicine and palliative care. Best Pract Res Clin Obstet Gynaecol; 2001 Apr;15(2):291-304
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  • Malignant pleural effusion is a poor prognostic factor: management options include repeated thoracentesis, chemical pleurodesis, symptomatic relief of dyspnoea with oxygen and morphine, and external drainage.
  • Parenchymal metastases are typically multifocal and respond to chemotherapy, with a limited role for pulmonary metastatectomy.
  • Pulmonary tumour embolism is frequently associated with lymphangitic carcinomatosis, and is most common in choriocarcinoma.
  • Thromboembolic disease, associated with the hypercoagulable state of cancer, is treated with anticoagulation.
  • Inferior vena cava filter placement is indicated when anticoagulation cannot be given, or when emboli recur despite adequate anticoagulation.
  • Opiates are effective at relieving dyspnoea associated with effusions, metatases, and lymphangitic tumour spread.
  • Non-pharmacological therapies include energy conservation, home redesign, and dyspnoea relief strategies, including pursed lip breathing, relaxation, oxygen, circulation of air with a fan, and attention to spiritual suffering.
  • Identification and treatment of gastroesophageal reflux, sinusitis, and asthma can improve many patients' coughs.
  • Chest wall pain responds to local radiotherapy, nerve blocks or systemic analgesia.
  • Case examples illustrate ways to address quality of life issues.
  • [MeSH-major] Genital Neoplasms, Female / complications. Genital Neoplasms, Female / therapy. Lung Diseases / etiology. Palliative Care / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Airway Obstruction / therapy. Cough / therapy. Dyspnea / therapy. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Meige Syndrome / surgery. Pleural Effusion, Malignant / therapy. Pulmonary Embolism / diagnosis. Pulmonary Embolism / drug therapy. Quality of Life. Vena Cava Filters

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  • [Copyright] Copyright 2001 Harcourt Publishers Ltd.
  • (PMID = 11358403.001).
  • [ISSN] 1521-6934
  • [Journal-full-title] Best practice & research. Clinical obstetrics & gynaecology
  • [ISO-abbreviation] Best Pract Res Clin Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 65
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14. Hiraki M, Sato S, Kai K, Ohtsuka T, Kohya N, Kitajima Y, Nakafusa Y, Tokunaga O, Miyazaki K: A long-time survivor of alpha-fetoprotein-producing gastric cancer successfully treated by fluoropyrimidine-based chemotherapy: a case study. Clin J Gastroenterol; 2009 Oct;2(5):331-337

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A long-time survivor of alpha-fetoprotein-producing gastric cancer successfully treated by fluoropyrimidine-based chemotherapy: a case study.
  • A 67-year-old male with advanced gastric cancer and lymph node metastasis as well as a tumor embolus in the portal vein was treated by S-1/cisplatin therapy.
  • After one course of chemotherapy, the patient showed stable disease; the serum level of alpha-fetoprotein also decreased to 626 ng/ml after a transient increase, and therefore reduction surgery was performed.
  • A total gastrectomy with a distal pancreatectomy, splenectomy, and regional lymph node dissection was performed.
  • There were no metastatic foci in the resected lymph nodes, presumably due to the preoperative chemotherapy.
  • S-1/cisplatin therapy was continued after the operation to treat the remaining tumor embolus in the portal vein.
  • After one course of this therapy, the tumor embolus disappeared.
  • However, a lymph node measuring 1.5 cm in diameter appeared in the hepatoduodenal ligament.
  • Therefore, the chemotherapy was changed to paclitaxel monotherapy.
  • After 2 courses of paclitaxel monotherapy, the lymph node swelled, and thus 5'-deoxy-5-fluorouridine was added to the paclitaxel regimen.
  • After 5 courses of this regimen, the lymph node swelling disappeared without any other new lesions and a total of 21 courses were performed.
  • The ortate phosphoribosyltransferase expression was strongly positive, and the good outcome in this case may have been associated with this result.

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  • (PMID = 26192608.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Chemoresistance / Dihydropyrimidine dehydrogenase / Ortate phosphoribosyltransferase / Thymidylate synthase
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15. Grass H, Schuff A, Staak M, Dienes HR, von Both I: Tumor embolism as a cause of an unexpected death: a case report. Pathol Res Pract; 2003;199(5):349-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor embolism as a cause of an unexpected death: a case report.
  • The primary causes of deaths for individuals with rare cancers can be difficult to diagnose clinically.
  • This study analyzes the death of a 45-year-old woman who reportedly died from an acute pulmonary dysfunction.
  • The autopsy revealed a bulky thyroid tumor with venous invasion, leading to a massive pulmonary tumor embolism.
  • Furthermore, microscopy identified the tumor as a rare pleomorphic myxoid sarcoma.
  • Thus, the patient died of a large pulmonary tumor embolism originating from this rare sarcoma, and not of acute pulmonary dysfunction of any other means.
  • [MeSH-major] Cause of Death. Neoplastic Cells, Circulating / pathology. Pulmonary Embolism / etiology. Sarcoma / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Female. Humans. Middle Aged. Pneumonia / complications. Pneumonia / drug therapy

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  • (PMID = 12908527.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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16. Ramos M, Benavente S, Giralt J: Management of squamous cell carcinoma of the head and neck: updated European treatment recommendations. Expert Rev Anticancer Ther; 2010 Mar;10(3):339-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of squamous cell carcinoma of the head and neck: updated European treatment recommendations.
  • Risk factors for adjuvant radiotherapy are stage III-IV, perineural involvement or vascular tumor embolism.
  • For patients with nonresectable disease we recommend treatment with concomitant chemoradiation, although this has important acute and late toxicity.
  • Concomitant EGF receptor inhibitors and taxane-based induction chemotherapy are new strategies under study that have demonstrated some benefits but are not yet the standard treatment.
  • Intensity-modulated radiotherapy allows one to decrease radiation dose to organs.
  • Preclinical work in signaling pathways and other oncogenic factors (e.g., human papillomavirus infection) will be the key to improving outcomes of head and neck cancer patients in the future.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Carcinoma, Squamous Cell / therapy. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Europe / epidemiology. Humans. Neoplasm Staging. Practice Guidelines as Topic. Radiotherapy, Adjuvant / adverse effects. Radiotherapy, Adjuvant / methods. Radiotherapy, Intensity-Modulated / methods. Risk Factors

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  • (PMID = 20214515.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 35
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17. Marconnet L, Bouchot O, Culine S, Avances C, Rigaud J, membres du CCAFU-OGE: [Treatment of lymph nodes in epidermoid carcinoma of the penis: review of literature by the Committee of Cancerology of the French Association of Urology-External Genital Organs Group (CCAFU-OGE)]. Prog Urol; 2010 May;20(5):332-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of lymph nodes in epidermoid carcinoma of the penis: review of literature by the Committee of Cancerology of the French Association of Urology-External Genital Organs Group (CCAFU-OGE)].
  • [Transliterated title] Prise en charge ganglionnaire dans le carcinome épidermoïde du pénis: revue de la littérature par le comité de cancérologie de l'Association française d'urologie-groupe organes génitaux externes (CCAFU-OGE).
  • INTRODUCTION: Invasive lymph nodes are an independent factor of prognosis and essential for the survival of patients with cancer of the penis.
  • The aim of this article is to analyse published research results on the diagnosis and treatment of lymph nodes in cancer of the penis.
  • MATERIAL AND METHOD: Bibliographic research on Medline was carried out using the terms penile carcinoma, lymph node dissection, lymphadenectomy, survival, chemotherapy and radiotherapy.
  • RESULTS: The risk of lymph node metastasis depends on the stage of the primitive tumour, its histological grade, the presence of venous and lymphatic embolus and the presence of palpable lymph nodes (classification into risk groups by the European Association of Urology [EAU]).
  • A diagnosis of suspected adenopathy based on clinical examination associated with FNA biopsy is essential.
  • The search for the sentinel lymph node although interesting remains to be defined, especially in patients who have no palpated adenopathy but are at risk of metastasis.
  • Not only is surgery on inguinal lymph nodes the only reliable way of confirming an invasive metastatic lymph node, it also plays a therapeutic and prognostic role for patients who have a tumour of the penis which risks spreading to lymph nodes (intermediate or high risk according to EAU).
  • The type of dissection is in function with the clinical examination: a radical inguinal dissection is recommended in the case of palpated adenopathy and a modified inguinal dissection is recommended if there is no palpated adenopathy, this should be radicalised in the case of metastatic adenopathy on histological examination.
  • Neo-adjuvant or adjuvant chemotherapy would appear to play a interesting role when combined with surgery for certain patients without there being currently being precise consensus because of the lack of documented cases.
  • The same goes for external radiotherapy on inguinal lymph nodes which seems to play a role in local controls of the lymph node disease though increases morbidity risks of surgical intervention.
  • CONCLUSION: Lymph node dissection alone has a therapeutic role in patients who have reached metastasis of lymph nodes (stage pN1).
  • However, it remains insufficient for patients who have metastatic infiltration of more than 2 lymph nodes (stage > or =pN2).
  • Consequently, it would seem important to develop multimodal approaches in the treatment of these patients in order to increase the rate of response to treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lymph Node Excision. Penile Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. France. Humans. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Societies, Medical. Urology

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20471577.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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18. Carron M, Ori C: Thrombolysis for massive pulmonary tumour embolism in a patient with cavoatrial renal carcinoma. Br J Anaesth; 2008 Aug;101(2):285-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thrombolysis for massive pulmonary tumour embolism in a patient with cavoatrial renal carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Heart Neoplasms / secondary. Neoplastic Cells, Circulating / drug effects. Pulmonary Embolism / drug therapy. Thrombolytic Therapy / methods
  • [MeSH-minor] Humans. Male. Middle Aged. Tissue Plasminogen Activator / therapeutic use

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  • (PMID = 18614604.001).
  • [ISSN] 1471-6771
  • [Journal-full-title] British journal of anaesthesia
  • [ISO-abbreviation] Br J Anaesth
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.21.68 / Tissue Plasminogen Activator
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