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Items 1 to 18 of about 18
1. Franco MI, Waisberg J, Lopes LS: Multiple lymphomatous polyposis of the gastrointestinal tract. Sao Paulo Med J; 2004 May 6;122(3):131-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple lymphomatous polyposis of the gastrointestinal tract.
  • CONTEXT: Gastrointestinal multiple lymphomatous polyposis is a rare type of malignant lymphoma that has aggressive biological behavior, early systemic dissemination and poor prognosis.
  • OBJECTIVE: A case of gastrointestinal multiple lymphomatous polyposis is presented and the anatomopathological, clinical, diagnostic and treatment aspects of this unusual neoplasia are discussed.
  • CASE REPORT: The patient was a 59-year-old white male with a complaint of asthenia, night sweating, alteration in intestinal habit and weight loss over the preceding two months.
  • Endoscopy of the upper digestive tract showed the presence of gastric and duodenal polyps.
  • An opaque enema showed multiple polypoid lesions, especially in the cecum.
  • Immunohistochemical study showed lymphocytes that expressed the antibody CD20 (L-26) and light-chain kappa (k) immunoglobulin, but not light-chain lambda (l) immunoglobulin.
  • The patient presented a condition of acute intestinal obstruction with the presence of a mesenteric mass formed by agglutinated lymph nodes that surrounded the proximal ileum, thereby obstructing its lumen.
  • After two cycles of chemotherapy there was a worsening of the general state, with an increase in the dimensions of the abdominal masses and sepsis, accompanied by progressive respiratory insufficiency, leading to death.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology. Intestinal Polyposis / pathology. Lymphoma, Mantle-Cell / pathology
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Humans. Male. Middle Aged

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  • (PMID = 15448813.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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2. Kella VK, Constantine R, Parikh NS, Reed M, Cosgrove JM, Abo SM, King S: Mantle cell lymphoma of the gastrointestinal tract presenting with multiple intussusceptions--case report and review of literature. World J Surg Oncol; 2009;7:60
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  • [Title] Mantle cell lymphoma of the gastrointestinal tract presenting with multiple intussusceptions--case report and review of literature.
  • BACKGROUND: Mantle cell lymphoma (MCL) is an aggressive type of B-cell non-Hodgkin's lymphoma that originates from small to medium sized lymphocytes located in the mantle zone of the lymph node.
  • Extra nodal involvement is present in the majority of cases, with a peculiar tendency to invade the gastro-intestinal tract in the form of multiple lymphomatous polyposis.
  • Here we present a rare case of multiple intussusceptions caused by mantle cell lymphoma and review the literature of this disease.
  • CASE PRESENTATION: A 68-year-old male presented with pain, tenderness in the right lower abdomen, associated with nausea and non-bilious vomiting.
  • Laparoscopy confirmed multiple intussusceptions involving ileo-colic and ileo-ileal segments of gastrointestinal tract.
  • The histology and immuno-histochemistry of the excised small and large bowel revealed mantle cell lymphoma with multiple lymphomatous polyposis and positivity to Cyclin D1 marker.
  • The patient was successfully treated with Rituximab-CHOP chemotherapy and remains in complete remission at one-year follow-up.
  • CONCLUSION: This is a rare case of intestinal lymphomatous polyposis due to mantle cell lymphoma presenting with multiple small bowel intussusceptions.
  • Our case highlights laparoscopic-assisted bowel resection as a potential and feasible option in the multi-disciplinary treatment of mantle cell lymphoma.
  • [MeSH-minor] Aged. Humans. Male


3. Meral M, Demirpençe M, Gönen C, Akarsu M, Kayahan H, Demirkan F, Kargi A, Akpinar H: Diffuse gastrointestinal involvement of mantle cell lymphoma. Turk J Gastroenterol; 2008 Jun;19(2):117-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffuse gastrointestinal involvement of mantle cell lymphoma.
  • The most frequent endoscopic finding of mantle cell lymphoma is multiple lymphomatous polyposis, which is a very rare entity.
  • Multiple lymphomatous polyposis is characterized by multiple polypoid lesions involving long segments of the gastrointestinal tract and it accounts for 2% of primary gastrointestinal tract lymphomas.
  • Multiple lymphomatous polyposis was detected on the endoscopic evaluations.
  • The patient was successfully treated by combination chemotherapy.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Intestinal Polyposis / diagnosis. Lymphoma, Mantle-Cell / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Barium. Biopsy. Colon / pathology. Contrast Media. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Endoscopy, Digestive System. Humans. Intestine, Small / pathology. Male. Prednisolone / administration & dosage. Tomography, X-Ray Computed. Vincristine / administration & dosage

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  • (PMID = 19110668.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Contrast Media; 24GP945V5T / Barium; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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4. Isomoto H, Maeda T, Akashi T, Tsuchiya T, Kawaguchi Y, Sawayama Y, Koida S, Ohnita K, Kohno S, Tomonaga M: Multiple lymphomatous polyposis of the colon originating from T-cells: a case report. Dig Liver Dis; 2004 Mar;36(3):218-21
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  • [Title] Multiple lymphomatous polyposis of the colon originating from T-cells: a case report.
  • Multiple lymphomatous polyposis is an unusual form of non-Hodgkin's lymphoma characterised by myriad polyps throughout the alimentary tract.
  • Most multiple lymphomatous polyposis cases are derived from B-cell, and there has been little information on multiple lymphomatous polyposis of T-cell origin.
  • A 67-year-old Japanese man presented with lower abdominal pain and diarrhoea of 4-week duration.
  • The patient was treated with combined chemotherapy, leading to complete resolution of the lesions.
  • [MeSH-minor] Aged. Humans. Male. T-Lymphocytes / pathology

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  • (PMID = 15046193.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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5. Hsieh YC, Lin CL, Tsao CJ, Hsieh PP, Tzeng CC, Chuang SS: Aberrant expression of CD19 and CD43 in a patient with therapy-related acute myeloid leukemia and a history of mantle cell lymphoma. Kaohsiung J Med Sci; 2009 Jul;25(7):389-94
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  • [Title] Aberrant expression of CD19 and CD43 in a patient with therapy-related acute myeloid leukemia and a history of mantle cell lymphoma.
  • Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma with frequent involvement of the gastrointestinal tract and peripheral blood (PB).
  • In patients with a prior history of MCL with PB involvement, the appearance of leukemic cells after chemotherapy usually heralds a relapse, particularly if the leukemic cells express B cell markers and CD43.
  • We report a patient with MCL who presented with multiple lymphomatous polyposis of the intestine.
  • The staging procedures revealed the involvement of lymph nodes, bone marrow and PB.
  • Three years after chemotherapy, thrombocytopenia with the appearance of rare leukemic cells in the PB was noted.
  • Detailed cytomorphological and immunophenotypic studies unveiled the myeloid nature of these leukemic cells, and a diagnosis of therapy-related acute myeloid leukemia was made.
  • This case illustrates the importance of morphologic examination and performing a complete antibody panel in the diagnosis of a suspected relapse in patients with a prior history of lymphoma.
  • [MeSH-major] Antigens, CD19 / immunology. Antigens, CD43 / immunology. Gene Expression Regulation, Neoplastic. Leukemia, Myeloid, Acute / etiology. Leukemia, Myeloid, Acute / immunology. Lymphoma, Mantle-Cell / immunology
  • [MeSH-minor] Flow Cytometry. Humans. Male. Middle Aged

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  • (PMID = 19605331.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Antigens, CD19; 0 / Antigens, CD43
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6. Remes-Troche JM, De-Anda J, Ochoa V, Barreto-Zuñiga R, Arista-Nasr J, Valdovinos MA: A rare case of multiple lymphomatous polyposis with widespread involvement of the gastrointestinal tract. Arch Pathol Lab Med; 2003 Aug;127(8):1028-30

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  • [Title] A rare case of multiple lymphomatous polyposis with widespread involvement of the gastrointestinal tract.
  • Multiple lymphomatous polyposis (MLP) is an uncommon type of primary non-Hodgkin gastrointestinal (GI) B-cell lymphoma characterized by the presence of multiple polyps along the GI tract.
  • Malignant cells of MLP have mantle cell characteristics and thus are considered to be the counterpart of the mantle cell lymphoma (MCL) in the GI tract.
  • We report the case of 53-year-old man diagnosed as having MLP.
  • The patient presented with diffuse abdominal pain, chronic lower GI bleeding, peripheral lymphadenopathy, and weight loss.
  • The lymphomatous polyps extended from the esophagus to the rectum, with bone marrow infiltration.
  • The patient was treated with a combined cyclophosphamide, vincristine, and prednisone chemotherapy regimen, resulting in a partial response.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Lymphoma, Mantle-Cell / drug therapy. Lymphoma, Mantle-Cell / pathology. Male. Middle Aged

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  • (PMID = 12873180.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Hokama A, Tomoyose T, Yamamoto Y, Watanabe T, Hirata T, Kinjo F, Kato S, Ohshima K, Uezato H, Takasu N, Fujita J: Adult T-cell leukemia/lymphoma presenting multiple lymphomatous polyposis. World J Gastroenterol; 2008 Nov 14;14(42):6584-8
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  • [Title] Adult T-cell leukemia/lymphoma presenting multiple lymphomatous polyposis.
  • Multiple lymphomatous polyposis (MLP) is an unusual form of non-Hodgkin's lymphoma characterized by polyps throughout the gastrointestinal tract.
  • It has been reported that most MLP are observed in cases with mantle cell lymphoma of B-cell type.
  • We herein present a case of a 66-year-old man with adult T-cell leukemia/lymphoma (ATLL).
  • The patient died despite combination of chemotherapy.
  • The literature of manifestations of colonic involvement of ATLL is reviewed and the importance of endoscopic evaluation to differentiate ATLL intestinal lesions from opportunistic infectious enterocolitis is discussed.
  • [MeSH-major] Colonic Polyps / etiology. Intestinal Polyposis / etiology. Leukemia-Lymphoma, Adult T-Cell / complications
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols. Colonoscopy. Diagnosis, Differential. Fatal Outcome. Humans. Male. Middle Aged. Treatment Failure

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  • (PMID = 19030219.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 24
  • [Other-IDs] NLM/ PMC2773353
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8. Karoui S, Kchir N, Jemni F, Khalfallah S, Boubaker J, Boussen H, Zitouna MM, Filali A: [Multiple lymphomatous polyposis of the gastrointestinal tract: a Tunisian case]. Tunis Med; 2004 May;82(5):457-60
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  • [Title] [Multiple lymphomatous polyposis of the gastrointestinal tract: a Tunisian case].
  • [Transliterated title] Polypose lymphomateuse multiple du tube digestif: un cas Tunisien.
  • Multiple lymphomatous polyposis is a distinctive primary gastrointestinal lymphoma which endoscopical, histopathological et immunophenotypical characteristics are well known.
  • This lymphoma is rare and its prognosis is bad because of frequency of stage IV patients.
  • We report the case of a 75-year-old male patient with multiple lymphomatous polyposis affecting the rectum, the colon and the stomach associated with an involvement of lymphadenopathies, bone marrow and liver.
  • Treatment by chemotherapy was ineffective and patient dead after 3 sessions of CEOP protocol.
  • [MeSH-minor] Aged. Humans. Male. Tunisia

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  • (PMID = 15453049.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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9. Ruskoné-Fourmestraux A, Audouin J: Primary gastrointestinal tract mantle cell lymphoma as multiple lymphomatous polyposis. Best Pract Res Clin Gastroenterol; 2010 Feb;24(1):35-42
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  • [Title] Primary gastrointestinal tract mantle cell lymphoma as multiple lymphomatous polyposis.
  • Primary gastrointestinal involvement of mantle cell lymphoma (MCL) is rare with a frequency reported between 4 and 9% of all gastrointestinal B-cell non-Hodgkin lymphomas.
  • It was first described and so-called as multiple lymphomatous polyposis (MLP).
  • Its clinical presentation is usually characteristic, with multiple lymphomatous polyps involving several digestive tract segments and a marked tendency towards extra-intestinal spread.
  • The constant and typical phenotypic features of the small cleaved tumour cells, characterised as CD20+, CD5+ CD23- with a t(11;14) (q13;q32) and cyclin D1 overexpression on immunochemistry, allow MLP to be considered as the gastrointestinal counterpart of peripheral nodal MCL.
  • Response to intensive chemotherapy regimens usually results in regression of macroscopic and sometimes microscopic lesions but remissions are short and median survival from 3 to 4 years.
  • Earlier diagnosis with further studies integrating novel agents are still required to determine the optimal treatment with less toxicity.
  • [MeSH-major] Gastrointestinal Neoplasms. Intestinal Polyposis. Lymphoma, Mantle-Cell
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Stem Cell Transplantation. Transplantation, Autologous. Treatment Outcome

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  • [Copyright] 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20206107.001).
  • [ISSN] 1532-1916
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 46
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10. García Aguilera X, González Martín JA, Peñas García B, Vázquez Sequeiros E, Montalbán Sanz C, Redondo Verge C: [Multiple lymphomatous polyposis, favorable outcome after chemotherapy]. Gastroenterol Hepatol; 2009 Oct;32(8):562-4
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  • [Title] [Multiple lymphomatous polyposis, favorable outcome after chemotherapy].
  • [Transliterated title] Poliposis linfomatosa múltiple, evolución favorable tras tratamiento quimioterapéutico.
  • Multiple lymphomatous polyposis is a rare type of non Hodgkin lymphoma that has aggressive biological behavior, early systemic dissemination and poor prognosis.
  • We describe a case of a 55 year old man, with favorable outcome after chemotherapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Intestinal Polyposis / drug therapy. Lymphoma, Mantle-Cell / drug therapy
  • [MeSH-minor] Humans. Male. Middle Aged. Remission Induction

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  • (PMID = 19523717.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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11. Nakamura S, Matsumoto T, Iida M: [Malignant lymphoma of the small intestine]. Nihon Rinsho; 2008 Jul;66(7):1297-302
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  • [Title] [Malignant lymphoma of the small intestine].
  • The clinicopathologic features of malignant lymphoma of the small intestine were reviewed.
  • Macroscopically, small intestinal lymphomas are classified as polypoid, ulcerative (including stricturing, non-stricturing and aneurysmal forms on radiography), multiple lymphomatous polyposis, diffuse, or other types.
  • A significant correlation is observed between these macroscopic/radiographic and histologic types.
  • The therapeutic strategy, such as surgery, chemotherapy, antibiotics or watch-and-wait, should be determined based on the disease extent, histologic type, and clinical stage.

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  • (PMID = 18616120.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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12. D'Antonio A, Boscaino A, Addesso M, Liguori G, Nappi O: Nonpolypoid intestinal mantle cell lymphoma resembling MALT lymphoma with successful response to rituximab. South Med J; 2008 Nov;101(11):1168-9
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  • They involved the ileum and right colon without multiple lymphomatous polyposis and morphologically resembled an extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Immunologic Factors / therapeutic use. Lymphoma, Mantle-Cell / drug therapy. Lymphoma, Mantle-Cell / physiopathology
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Humans. Male. Prednisone / therapeutic use. Rituximab. Vincristine / therapeutic use

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  • (PMID = 19088534.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunologic Factors; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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13. Iwamuro M, Okada H, Takenaka R, Kawahara Y, Shinagawa K, Morito T, Ichimura K, Yoshino T, Yamamoto K: [Nine cases of mantle cell lymphoma with gastrointestinal involvement]. Nihon Shokakibyo Gakkai Zasshi; 2009 Apr;106(4):520-8
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  • [Title] [Nine cases of mantle cell lymphoma with gastrointestinal involvement].
  • Nine cases of mantle cell lymphoma with gastrointestinal involvement were retrospectively reviewed, and their clinical features, including the involved organs, macroscopic forms, treatment methods, and prognoses were evaluated.
  • The macroscopic form of the gastric involvement varied, and included the protruding type in 3 cases, the ulcerated type in one, and the superficial type in one.
  • On the other hand, the macroscopic form of the intestinal involvement from the duodenum to the rectum was mostly of the multiple lymphomatous polyposis type, which was observed in 6 cases.
  • A hyper CVAD/MA regimen and high-dose chemotherapy with autologous peripheral blood stem cell transplantation was performed in 5 cases.
  • [MeSH-minor] Aged. Humans. Male. Middle Aged

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  • (PMID = 19346720.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 33
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14. Huang WT, Hsu YH, Yang SF, Chuang SS: Primary gastrointestinal follicular lymphoma: a clinicopathologic study of 13 cases from Taiwan. J Clin Gastroenterol; 2008 Oct;42(9):997-1002
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  • [Title] Primary gastrointestinal follicular lymphoma: a clinicopathologic study of 13 cases from Taiwan.
  • Primary gastrointestinal follicular lymphoma (GIFL) is rare and most commonly occurs in the elder women with indolent clinical course, mainly in the duodenum and terminal ileum.
  • RESULTS: There were 5 men and 8 women with a median age of 58 years (range, 31 to 74; mean, 55).
  • Multiple lymphomatous polyposis was present in 6 patients (46%).
  • Five (45%) of 11 tumors with surgical resection showed transmural involvement.
  • Most of the cases revealed a predominantly follicular pattern (7/13, 54%) and low-grade disease (grades 1 and 2; 10/13, 77%).
  • Five patients (38%) were at stage IE and 8 (62%) at stage IIE.
  • Treatment included surgery with or without chemotherapy.
  • At a median follow-up time of 51 months (range, 3 to 180; mean, 63), 11 patients (85%) were disease free and no patient died of lymphoma.
  • CONCLUSIONS: We characterized the clinicopathologic features of the first series of GIFL in Taiwan.
  • These tumors frequently involved ileum with a favorable prognosis.
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Gene Expression Regulation, Neoplastic. Humans. Ileum / pathology. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Remission Induction. Retrospective Studies. Taiwan / epidemiology

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  • (PMID = 18719510.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Tamura S, Ohkawauchi K, Yokoyama Y, Higashidani Y, Daibata M, Hiroi M, Yamamori S, Onishi S: Non-multiple lymphomatous polyposis form of mantle cell lymphoma in the gastrointestinal tract. J Gastroenterol; 2004 Oct;39(10):995-1000
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-multiple lymphomatous polyposis form of mantle cell lymphoma in the gastrointestinal tract.
  • Multiple lymphomatous polyposis (MLP) is an uncommon disease that is regarded as the intestinal form of MCL.
  • We present a rare case of gastrointestinal MCL without MLP, and demonstrate that rituximab was effective for the treatment of this patient.
  • A 61-year-old man presented with continuous diarrhea and hematochezia for a period of 5 months.
  • Superficial lymph nodes were not palpable, but both tonsilla were enlarged.
  • Upper gastrointestinal endoscopy showed a slightly rough gastric mucosal surface, and chicken-skin like mucosa was observed in the second portion of the duodenum.
  • Polymerase chain reaction analysis revealed a chromosomal translocation t(11;14)(q13;q32) in the bcl-1 gene.
  • We diagnosed this as a case of MCL from these findings.
  • For treatment, the patient received a total of ten courses of combination chemotherapy consisting of cyclophosphamide (1000 mg), doxorubicin (70 mg), vincristine (2 mg) and prednisolone (50 mg) (CHOP), which led to a partial remission.
  • As the infiltrating lymphoma cells expressed CD20 molecules on their surfaces, the patient was treated with a chimeric anti-CD20 monoclohal antibody, rituximab, which showed significant efficacy, and a second partial remission was achieved.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Gastrointestinal Neoplasms / drug therapy. Lymphoma, Mantle-Cell / drug therapy. Prednisolone / therapeutic use. Vincristine / therapeutic use
  • [MeSH-minor] Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Agents / therapeutic use. Colonoscopy. Endoscopy, Gastrointestinal. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction. Remission Induction. Rituximab. Translocation, Genetic

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  • [CommentIn] J Gastroenterol. 2004 Oct;39(10):1023-4 [15549463.001]
  • (PMID = 15549454.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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16. Michopoulos S, Petraki K, Matsouka C, Kastritis E, Chrysanthopoulou H, Dimopoulos MA: Mantle-cell lymphoma (multiple lymphomatous polyposis) of the entire GI tract. J Clin Oncol; 2008 Mar 20;26(9):1555-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mantle-cell lymphoma (multiple lymphomatous polyposis) of the entire GI tract.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Gastrointestinal Neoplasms / diagnosis. Gastrointestinal Neoplasms / drug therapy. Lymphoma, Mantle-Cell / diagnosis. Lymphoma, Mantle-Cell / drug therapy
  • [MeSH-minor] Aged. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Boronic Acids / administration & dosage. Bortezomib. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Drug Administration Schedule. Gastrointestinal Hemorrhage / etiology. Humans. Immunohistochemistry. Male. Prednisone / administration & dosage. Prognosis. Pyrazines / administration & dosage. Rituximab. Severity of Illness Index. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 18349408.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Boronic Acids; 0 / Pyrazines; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 69G8BD63PP / Bortezomib; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone
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17. Watanabe T, Homma N, Ogata N, Saito H, Kanefuji T, Hasegawa K, Soga K, Shibasaki K, Endo T, Ajioka Y: Complete response in a patient with colonic mantle cell lymphoma with multiple lymphomatous polyposis treated with combination chemotherapy using anti-CD20 antibody and cladribine. Gut; 2007 Mar;56(3):449-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete response in a patient with colonic mantle cell lymphoma with multiple lymphomatous polyposis treated with combination chemotherapy using anti-CD20 antibody and cladribine.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Lymphoma, Mantle-Cell / drug therapy

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  • [Cites] Nihon Shokakibyo Gakkai Zasshi. 2003 Dec;100(12):1382-8 [14748324.001]
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  • [CommentIn] Gut. 2007 Oct;56(10):1479; author reply 1479-80 [17872581.001]
  • (PMID = 17339260.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 47M74X9YT5 / Cladribine; 4F4X42SYQ6 / Rituximab
  • [Other-IDs] NLM/ PMC1856801
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18. Mukogawa T, Fujii H, Koyama F, Matsumoto H, Kojima Y, Takeuchi T, Yagi H, Arai M, Nakajima Y: [Anti-CD20 antibody and combination chemotherapy followed by autologous peripheral blood stem cell transplantation after high-dose chemotherapy induced complete remission in a case of multiple lymphomatous polyposis of the gastrointestinal tract]. Nihon Shokakibyo Gakkai Zasshi; 2003 Dec;100(12):1382-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anti-CD20 antibody and combination chemotherapy followed by autologous peripheral blood stem cell transplantation after high-dose chemotherapy induced complete remission in a case of multiple lymphomatous polyposis of the gastrointestinal tract].
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Intestinal Neoplasms / therapy. Intestinal Polyposis / therapy. Lymphoma, Mantle-Cell / therapy. Peripheral Blood Stem Cell Transplantation
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Cyclophosphamide / administration & dosage. Cytarabine / administration & dosage. Dexamethasone / administration & dosage. Drug Administration Schedule. Etoposide / administration & dosage. Humans. Male. Middle Aged. Remission Induction. Rituximab

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  • (PMID = 14748324.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 04079A1RDZ / Cytarabine; 4F4X42SYQ6 / Rituximab; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; 8N3DW7272P / Cyclophosphamide; CHASE protocol
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