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1. Gono T, Shimojima Y, Hoshi K, Yamamoto K, Tokuda T, Shikama N, Matsuda M, Ikeda S: Malignant lymphoma associated with rheumatoid arthritis, developing shortly after initiation of oral methotrexate. Intern Med; 2004 Feb;43(2):135-8
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  • [Title] Malignant lymphoma associated with rheumatoid arthritis, developing shortly after initiation of oral methotrexate.
  • We report a patient with rheumatoid arthritis (RA) who developed malignant lymphoma of the diffuse large B-cell type in the right submandibular region shortly after initiation of oral methotrexate (MTX).
  • Despite cessation of MTX, the lymphadenopathy did not regress, and only reached complete remission after 3 courses of CHOP therapy followed by irradiation.
  • In this patient highly active RA itself was considered to be the main cause of malignant lymphoma, and MTX might have contributed to the development by modifying the immune system.
  • When RA is highly active, MTX should be used carefully because of the possible development of malignant lymphoma as well as other serious complications.
  • [MeSH-major] Antirheumatic Agents / therapeutic use. Arthritis, Rheumatoid / complications. Arthritis, Rheumatoid / drug therapy. Lymphoma, B-Cell / etiology. Lymphoma, Large B-Cell, Diffuse / etiology. Methotrexate / therapeutic use
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Mandibular Neoplasms / drug therapy. Mandibular Neoplasms / etiology. Middle Aged. Prednisolone / therapeutic use. Vincristine / therapeutic use


2. Iguchi T, Miyazawa K, Okabe S, Kawakubo K, Shimamoto T, Kuriyama Y, Ito Y, Kimura Y, Ohyashiki K, Serizawa H, Iwaya K, Mukai K: [Relapse of diffuse large B cell lymphoma to CD20-negative multiple cutaneous tumors immediately after anti-CD20 monoclonal antibody (rituximab) therapy]. Rinsho Ketsueki; 2004 Oct;45(10):1129-34
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  • [Title] [Relapse of diffuse large B cell lymphoma to CD20-negative multiple cutaneous tumors immediately after anti-CD20 monoclonal antibody (rituximab) therapy].
  • A 60-year-old male was referred to our hospital because of cervical lymphadenopathy and a left hilar abnormal shadow seen on chest X-ray in May 1999.
  • The pathological findings of the cervical lymph nodes revealed that the patient had a malignant lymphoma, of the diffuse large B cell type, at clinical stage IIIB.
  • Immunohistochemistry demonstrated that the lymphoma cells were positive for CD11a, CD19, CD20, CD23, CD25, CD45, IgM, IgD and lambda, but negative for CD5.
  • Although a complete remission was obtained after 8 courses of CHOP therapy, the patient relapsed 32 months later.
  • Two courses of a half dose of CHASE therapy consisting of CPM, ara-C, VP-16 and dexamethasone, followed by rituximab (600 mg/week x4) resulted in a transient re-induction of complete remission.
  • However, multiple cutaneous tumors became apparent just 10 days after the last rituximab therapy.
  • Immunohistochemistry of the cutaneous tumors revealed infiltration of CD20-negative lymphoma cells.
  • A series of chemotherapy including high-dose MTX was ineffective, and the patient died in August 2003.
  • Autopsy findings revealed the systemic intra-capillary infiltration of CD20 negative-lymphoma cells into multiple organs, including the lungs, liver, and kidneys.
  • A CD20 negative-clone selected by rituximab therapy appeared to have expanded in this case.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antigens, CD20 / immunology. Antineoplastic Agents / therapeutic use. Head and Neck Neoplasms / drug therapy. Lymphoma, B-Cell / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy. Lymphoma, Large B-Cell, Diffuse / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Capillaries / pathology. Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasms, Vascular Tissue / pathology. Remission Induction. Rituximab


3. Suzuki T, Koga H, Yamazaki S, Saeki H, Tanaka H, Nishimura M, Nakaseko C, Nakasa H, Nakamura H, Ariyoshi N, Kitada M: Probable interaction between warfarin and antitumor agents used in R-ESHAP chemotherapy. Clin Ther; 2008 Jun;30(6):1155-9
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  • [Title] Probable interaction between warfarin and antitumor agents used in R-ESHAP chemotherapy.
  • BACKGROUND: The pharmacologic effects of warfarin might be altered by various factors, including drug-drug interaction.
  • CASE SUMMARY: A 49-year-old Japanese man (height, 174 cm; weight, 68 kg) presented with a 20-month history of malignant lymphoma (diffuse large B cell lymphoma, clinical stage IV).
  • He was treated with a combination of rituximab chemotherapy and etoposide, cisplatin, high-dose cytarabine, and methyl-prednisolone (R-ESHAP).
  • The INR was increased from 2.44 to 4.71 during chemotherapy but was returned to within the normal range (1.05; normal range: 0.81-1.009) 5 days after chemotherapy was completed.
  • CONCLUSION: In this patient, R-ESHAP chemotherapy might have affected warfarin anticoagulation sensitivity; thus, careful monitoring of INR is essential, particularly in patients receiving warfarin who undergo R-ESHAP chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Large B-Cell, Diffuse / drug therapy. Venous Thrombosis / drug therapy. Warfarin / therapeutic use
  • [MeSH-minor] Cisplatin / therapeutic use. Cytarabine / therapeutic use. Drug Interactions. Etoposide / therapeutic use. Follow-Up Studies. Humans. Male. Methylprednisolone / therapeutic use. Middle Aged. Pulmonary Embolism / etiology. Pulmonary Embolism / prevention & control

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  • (PMID = 18640471.001).
  • [ISSN] 0149-2918
  • [Journal-full-title] Clinical therapeutics
  • [ISO-abbreviation] Clin Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 5Q7ZVV76EI / Warfarin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; X4W7ZR7023 / Methylprednisolone; ESAP protocol
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4. Bolanowski M, Kuliszkiewicz-Janus M, Sokolska V: Diffuse malignant lymphoma type B with optic chiasm infiltration, visual disturbances, hypopituitarism, hyperprolactinaemia and diabetes insipidus. Case report and literature review. Endokrynol Pol; 2006 Nov-Dec;57(6):642-7
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  • [Title] Diffuse malignant lymphoma type B with optic chiasm infiltration, visual disturbances, hypopituitarism, hyperprolactinaemia and diabetes insipidus. Case report and literature review.
  • The case is reported of a 55-year-old man with diffuse malignant lymphoma type B associated with transient optic chiasm infiltration and visual disturbances but with persistent hypopituitarism, hyperprolactinaemia and diabetes insipidus.
  • The patient was administered chemotherapy and radiotherapy.
  • Repeated MR and CT scans showed optic chiasm infiltration, which disappeared in the course of the chemotherapy but then recurred, changed its appearance and finally disappeared again.
  • In the meantime visual disturbances occurred and disappeared during the therapy.
  • Hypopituitarism, diabetes insipidus and hyperprolactinaemia were diagnosed and replacement therapy was administered.
  • These were diffuse malignant lymphoma with regional lymphonodulitis in histology.
  • The patient died as a result of systemic complications of the disease.
  • The length of survival time documented following the hypothalamochiasmatic infiltration and diagnosis of lymphoma makes the case an unusual one for patients with CNS lymphoma.
  • Hormonal disturbances accompanying the suprasellar region infiltration are very important from the practical point of view.
  • [MeSH-major] Lymphoma, Non-Hodgkin / complications
  • [MeSH-minor] Diabetes Insipidus / etiology. Fatal Outcome. Humans. Hyperprolactinemia / etiology. Hypopituitarism / etiology. Male. Middle Aged. Optic Chiasm. Vision Disorders / etiology


5. Tanaka M, Matsuzaki J, Kitami K, Hirokawa M: [A case of primary malignant lymphoma of the pararectal space]. Hinyokika Kiyo; 2002 Sep;48(9):561-4
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  • [Title] [A case of primary malignant lymphoma of the pararectal space].
  • A 16-year-old man presented with lumbago, perianal pain and constipation.
  • A large tumor was palpable by digital rectal examination.
  • Then, transrectal needle biopsies of the tumor were performed.
  • Histopathological diagnosis was non-Hodgkin's malignant lymphoma (diffuse large B-cell type according to the new WHO classification).
  • The results of some examinations were compatible with the diagnosis of primary lymphoma of the pararectal space.
  • The patient underwent 2 courses of combination chemotherapy CHOP (consisting of cyclophosphamide, doxorubichin, vincristine, and prednisolone), and high-dose chemotherapy (ranimustine, etoposide, ifosfamide) with peripheral blood stem cell transplantation.
  • After high-dose chemotherapy, radiation therapy was performed since there was a possibility of residual tumor, and complete remission was achieved.
  • Now, 12 months after completion of the radiation, he remains free of the disease.
  • This is probably the first clinical case of malignant lymphoma of the pararectal space ever reported in the Japanese literature.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, B-Cell / therapy. Lymphoma, Large B-Cell, Diffuse / therapy. Peripheral Blood Stem Cell Transplantation. Rectal Neoplasms / therapy
  • [MeSH-minor] Adolescent. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Drug Administration Schedule. Humans. Male. Prednisone / administration & dosage. Vincristine / administration & dosage

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  • (PMID = 12402484.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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6. Yumura Y, Chiba K, Saito K, Hirokawa M: [Fournier's gangrene in a patient with malignant lymphoma: a case report]. Hinyokika Kiyo; 2000 Oct;46(10):735-7
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  • [Title] [Fournier's gangrene in a patient with malignant lymphoma: a case report].
  • We report a case of Fournier's gangrene.
  • An 83-year-old man underwent biopsy of left inguinal tumor as an outpatient.
  • Pathological diagnosis was malignant lymphoma (diffuse large cell type).
  • Three weeks later, he developed reddened scrotal swelling accompanied with high fever (> 39 degrees C).
  • On admission, antibiotic chemotherapy was initiated.
  • Although his general condition was improved, scrotal necrosis had developed.
  • A computed tomography scan demonstrated thickened subcutaneous tissue over the left lumbar region.
  • Excision of necrotic tissue and sequential irrigation using povidone iodine liquid were effective.
  • The patient then underwent chemotherapy for malignant lymphoma at the internal department.
  • [MeSH-major] Fournier Gangrene / etiology. Lymphoma, Large B-Cell, Diffuse / complications
  • [MeSH-minor] Aged. Aged, 80 and over. Genital Diseases, Male / etiology. Genital Diseases, Male / surgery. Humans. Immunocompromised Host. Male. Scrotum. Treatment Outcome

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  • (PMID = 11215202.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 5
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7. Okumoto T, Tomiyama K, Ino H, Kanaya Y, Maruyama S, Otani J, Yokoyama N, Soda M: [A case of malignant lymphoma of the stomach in which preoperative chemotherapy provided a complete response]. Gan To Kagaku Ryoho; 2002 Jun;29(6):943-7
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  • [Title] [A case of malignant lymphoma of the stomach in which preoperative chemotherapy provided a complete response].
  • We have encountered a case of malignant lymphoma of the stomach in which a complete remission was confirmed in a resected specimen after chemotherapy.
  • A 75-year-old woman complained of vomiting blood.
  • A biopsy from gastric endoscopy indicated malignant lymphoma of diffuse large B-cell type.
  • The patient was assumed to be inoperable due to enlargement of the tumor and lymph node metastasis, and THP-COP chemotherapy was carried out.
  • After four courses of the THP-COP regimen, endoscopic examination revealed a significant tumor reduction.
  • Total gastrectomy and splenectomy with lymph node dissection (D2) were performed after chemotherapy.
  • No tumor cells were detected in any sections of the specimen or regional lymph nodes.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Lymphoma, B-Cell / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy. Prednisolone / therapeutic use. Stomach Neoplasms / drug therapy. Vincristine / therapeutic use
  • [MeSH-minor] Aged. Female. Gastrectomy. Humans. Lymph Node Excision. Lymphatic Metastasis. Remission Induction. Splenectomy

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  • (PMID = 12090049.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VEP-THP protocol
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8. Lee G, Cho KS, Chon S, Joung YH, Choi CW, Kim SY, Yoon HJ: A Case of Intracardiac Lymphoma as a Presentation of Non Hodgkin's Lymphoma. Cancer Res Treat; 2001 Oct;33(5):438-41
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  • [Title] A Case of Intracardiac Lymphoma as a Presentation of Non Hodgkin's Lymphoma.
  • Lymphomatous involvement of the heart is extremely rare at initial diagnosis and presentation of malignant lymphoma.
  • We report a case of non-Hodgkin's lymphoma with two right atrial masses detected by chest computed tomography and transesophageal echocardiography.
  • The patient was an 80 year- old man and the presenting symptoms included generalized weakness, weight loss, constipation and low abdominal pain.
  • For diagnosis, the mass of the perinephric area was biopsied under ultrasonographic guidance, and pathologically it was determined to be malignant lymphoma, diffuse large B cell type.
  • The patient was treated with continuous low dose cyclophosphamide and prednisolone vice standard chemotherapy because of advanced age and renal dysfunction.
  • After 2 months of treatment the masses in the atrium and the intraabdominal masses disappeared.

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  • (PMID = 26680820.001).
  • [ISSN] 1598-2998
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
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9. Hamada S, Ito K, Kanbara T, Yoshii T, Sato K, Sumitomo M, Kimura F, Asano T: [A case of malignant lymphoma mimicking a seminal vesicle tumor]. Hinyokika Kiyo; 2010 Jul;56(7):393-6
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  • [Title] [A case of malignant lymphoma mimicking a seminal vesicle tumor].
  • A 76-year-old man was admitted to our hospital with severe diarrhea and syncope.
  • Abdominal computed tomography (CT) showed a mass 7 cm in diameter mimicking a seminal vesicle tumor and magnetic resonance imaging showed a heterogeneously enhanced mass with an unclear borderline to the rectum.
  • The differential diagnosis of the lesion included a tumor arising from a seminal vesicle, a local recurrence of rectal cancer, a rectal GIST, and a mesenchymal tumor.
  • Transrectal needle biopsy revealed non-Hodgkin's malignant lymphoma (diffuse large B cell lymphoma).
  • Chest and abdominal CT showed no specific findings except the lesion for the seminal vesicle lesion, but positron emission tomography showed accumulations in the gastrointestinal tract, pleura, and lymph nodes.
  • The patient was thus determined to have stage IV malignant lymphoma and was given two courses of combination chemotherapy including RCHOP.
  • The tumor responded to one course, but the patient died of neutropenic sepsis during the second course.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Seminal Vesicles
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 20724815.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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10. Hiramoto K, Kuroki M, Shoji H, Matsumura Y, Miura A, Kikuchi Y, Hirakawa H, Kimura J, Matsuda M: [A case of primary hepato-biliary malignant lymphoma effectively treated with R-CHOP chemotherapy]. Gan To Kagaku Ryoho; 2010 Jul;37(7):1345-8
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  • [Title] [A case of primary hepato-biliary malignant lymphoma effectively treated with R-CHOP chemotherapy].
  • A 65-year-old man was admitted to our hospital because of obstructive jaundice caused by a mass extending in the porta hepatis, neck of gall bladder and extrahepatic bile duct.
  • The specimens obtained with ultrasound-guided needle biopsy showed malignant lymphoma (diffuse large B-cell lymphoma: DLBCL).
  • CHOP with Rituximab therapy (R-CHOP therapy) was performed.
  • The treatment resulted in remarkable reduction of the tumor size and improvement of the biliary stenosis.
  • We should take into consideration malignant lymphoma when we see a patient with a tumor of the hepato-biliary system.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bile Duct Neoplasms / drug therapy. Liver Neoplasms / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy
  • [MeSH-minor] Aged. Antibodies, Monoclonal, Murine-Derived. Biopsy, Needle. Cyclophosphamide / administration & dosage. Cyclophosphamide / therapeutic use. Doxorubicin / administration & dosage. Doxorubicin / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Prednisone / administration & dosage. Prednisone / therapeutic use. Rituximab. Tomography, X-Ray Computed. Vincristine / administration & dosage. Vincristine / therapeutic use

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  • (PMID = 20647724.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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11. Shoji T, Konno H, Tanaka T, Baba M, Kamiya K, Kaneko T, Igarashi A, Nakamura S: Pancreaticoduodenectomy for perforated gastric malignant lymphoma: report of a case. Surg Today; 2002;32(5):468-71
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  • [Title] Pancreaticoduodenectomy for perforated gastric malignant lymphoma: report of a case.
  • We herein report the case of a 65-year old man with gastroduodenal malignant lymphoma (diffuse large B-cell type) accompanied with a bulbar perforation.
  • However, extensive lymphadenectomy was not carried out because many lymph nodes were involved.
  • The postoperative course was uneventful and CHOP therapy (pirarubicin 30 mg/m2, cyclophosphamide 500 mg/m2, vincristine 1 mg/m2, prednisolone 30 mg/m2) was started 1 month after surgery.
  • Seven cycles of CHOP therapy markedly reduced the residual lesions including lymph nodes, and a computed tomography scan after the final chemotherapy revealed no obvious lesions.
  • [MeSH-major] Lymphoma, B-Cell / surgery. Lymphoma, Large B-Cell, Diffuse / surgery. Pancreaticoduodenectomy. Stomach Neoplasms / surgery
  • [MeSH-minor] Aged. Duodenum / pathology. Humans. Male. Neoplasm Invasiveness. Palliative Care. Pancreas / pathology. Rupture, Spontaneous


12. Ogawa T, Mizutani M, Yabana T, Miyahara S, Murabayashi K: A Case of Burkitt's Lymphoma Involving Both Breasts. Breast Cancer; 2005;12(3):234-7
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  • [Title] A Case of Burkitt's Lymphoma Involving Both Breasts.
  • Primary malignant lymphoma of the breast is rare, and Burkitt's lymphoma is especially rare.
  • We report the case of a 44-year-old woman in whom Burkitt's lymphoma involving both breasts was diagnosed.
  • The patient was referred to our hospital because of a diffuse, firm swelling, like a bulky ball, in both breasts.
  • Fine-needle aspiration cytology (FNAC) of both breast masses revealed malignant lymphoma(ML), and diffuse large B-cell lymphoma was diagnosed based on the results of immunohistochemical studies of a core needle biopsy specimen.
  • The gallium scan revealed very hot lesions in both breasts, but there was no evidence of disseminated disease.
  • We instituted initial therapy, with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus intrathecal chemotherapy without performing a chromosome analysis, because the clinical course was very aggressive.
  • A CR was achieved, but after eight cycles of CHOP therapy, the ML relapsed.
  • We then resected the mass in the left breast, and when examination of the surgical specimen revealed relapse of ML and t (8;11) (q24;q32) translocation, Burkitt's lymphoma was diagnosed.
  • High-dose chemotherapy followed by peripheral-blood stem cell transplantation was performed, but the patient died 10 months after her initial presentation at our hospital.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / diagnosis. Burkitt Lymphoma / diagnosis. Diagnostic Errors
  • [MeSH-minor] Adult. Cyclophosphamide / therapeutic use. Cytarabine / therapeutic use. Dexamethasone / therapeutic use. Doxorubicin / therapeutic use. Etoposide / therapeutic use. Fatal Outcome. Female. Humans. Lymphoma, B-Cell / diagnosis. Lymphoma, B-Cell / therapy. Peripheral Blood Stem Cell Transplantation. Prednisone / therapeutic use. Vincristine / therapeutic use

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  • (PMID = 16110296.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHASE protocol; CHOP protocol
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13. Yabuki K, Tamasaki Y, Satoh K, Maekawa T, Matsumoto M: Primary gastric lymphoma with spontaneous perforation: report of a case. Surg Today; 2000;30(11):1030-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary gastric lymphoma with spontaneous perforation: report of a case.
  • Primary gastric lymphoma with spontaneous perforation is rare.
  • We report herein the case of a 53-year-old-man who was admitted to our hospital with severe epigastralgia.
  • Emergency endoscopic examination showed a perforated gastric tumor in the lower body of the greater curvature, and a distal subtotal gastrectomy with lymph node dissection was performed.
  • The resected tumor measured 10.0 x 8.0 cm and was associated with an area of ulceration, 8.0 x 6.0 cm in size, and perforation, 1.0 x 0.5 cm in size.
  • Pathological examination confirmed a diagnosis of B-cell malignant lymphoma of the diffuse, medium-sized cell type.
  • According to the Ann Arbor and Naqvi classifications, the lymphoma was stage II and stage III, respectively.
  • Postoperative adjuvant chemotherapy comprising cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) was given.
  • [MeSH-major] Intestinal Perforation / etiology. Lymphoma, B-Cell / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Chemotherapy, Adjuvant. Cyclophosphamide. Doxorubicin. Humans. Male. Middle Aged. Prednisone. Rupture, Spontaneous. Vincristine

  • Genetic Alliance. consumer health - Gastric Lymphoma.
  • MedlinePlus Health Information. consumer health - Stomach Cancer.
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • Hazardous Substances Data Bank. CYCLOPHOSPHAMIDE .
  • Hazardous Substances Data Bank. PREDNISONE .
  • Hazardous Substances Data Bank. VINCRISTINE .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 11110402.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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