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1. Picón MJ, Lara JI, Sarasa JL, Recasens JD, Clouet R, Gonzalo MA, Rovira A: Use of a long-acting gonadotrophin-releasing hormone analogue in a postmenopausal woman with hyperandrogenism due to a hilus cell tumour. Eur J Endocrinol; 2000 Jun;142(6):619
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  • [Title] Use of a long-acting gonadotrophin-releasing hormone analogue in a postmenopausal woman with hyperandrogenism due to a hilus cell tumour.
  • OBJECTIVE: The aim of this study was to prove the utility of GnRH analogues for the suppression of androgen secretion in a postmenopausal woman with a suspected virilizing ovarian tumour.
  • DESIGN AND METHODS: We present a case of a 72-year-old woman with virilization of recent onset.
  • Computed axial tomography scan of the ovaries was normal and the adrenal glands showed a discrete enlargement.
  • The long-acting GnRH analogue, triptorelin, was injected initially (3.75mg i.m.) and serum hormone levels were measured weekly throughout one month.
  • In order to achieve a diagnosis, the patient was submitted to a laparotomy that revealed a small hilus cell tumour in the left ovary.
  • CONCLUSION: GnRH analogues may offer a good therapeutic option in some states of gonadotrophin-dependent hyperandrogenism of ovarian origin.

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  • (PMID = 10822225.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 33515-09-2 / Gonadotropin-Releasing Hormone; 3XMK78S47O / Testosterone; 57773-63-4 / Triptorelin Pamoate
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2. Lyons G, Quadrelli S, Silva C, Vera K, Iotti A, Venditti J, Chertcoff J, Chimondeguy D: Analysis of survival in 400 surgically resected non-small cell lung carcinomas: towards a redefinition of the T factor. J Thorac Oncol; 2008 Sep;3(9):989-93
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  • [Title] Analysis of survival in 400 surgically resected non-small cell lung carcinomas: towards a redefinition of the T factor.
  • INTRODUCTION: The tumor, node, metastasis (TNM) system has been recognized internationally as the standard for staging disease extension, but despite the improvements of the 1997/2002 international staging system, there may be marked differences in postoperative 5-year survival rates within each stage.
  • There is controversy about the impact of tumor size itself as a variable unrelated to stage.The objective of this study was to analyze the influence of tumor size on the survival in patients with surgically resected non-small cell lung carcinoma (NSCLC).
  • METHODS: Between August 1985 and January 2006, 400 patients underwent pulmonary resection with a curative intention for non-small cell lung carcinoma.
  • Patients were excluded if they had received neoadjuvant chemotherapy.
  • The clinicopathological records of each patient were examined for prognostic factors such as age, sex, right or left side cancer, histology, tumor location, tumor size, clinical nodal stage number, and distribution of metastatic nodes.
  • Adenocarcinoma was the most common type (n = 245, 61.2%).
  • When only patients without neoplastic hilar or mediastinal metastases (pN0) were included, the difference in survival was significantly different in terms of tumor size (log rank 28.46, p < 0.0001).
  • Univariate analysis for the group of pN0 patients showed survival was not significantly affected by age, sex, side, or adenocarcinoma histology.
  • In the multivariate analysis, tumor size and the T factor were found to have maintained its independent prognostic effects on overall survival.
  • Among patients with pN0 tumors smaller that 15 mm in diameter, 5-year survival was 95% whereas patients with tumors bigger than 16 mm in diameter had a 5-year survival of 65% (p < 0.0001).
  • CONCLUSION: In conclusion, our data suggest that tumors over 15 mm are associated with shorter 5-year survival in all TNM stages.
  • Current TNM categories are not sufficiently discriminatory and the T factor requires to be reevaluated in further revisions of the TNM classification.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / mortality. Lung Neoplasms / pathology
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Pneumonectomy / mortality. Prognosis. Retrospective Studies. Survival Analysis. Survival Rate. Treatment Outcome

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  • (PMID = 18758301.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Ogawa S, Fukunaga K, Hiraoka R, Kohda E, Yamaguchi K, Ito D, Hata J: A case of poorly differentiated hilar lung adenocarcinoma of an unidentified histological type. Keio J Med; 2000 Dec;49(4):162-72
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  • [Title] A case of poorly differentiated hilar lung adenocarcinoma of an unidentified histological type.
  • The patient was a 74-year-old man, a physician, whose chief complaint was an unproductive cough.
  • The shadow of a mass was seen at the hilum of the left lung, and the mediastinal lymph nodes on both sides were swollen.
  • No histological diagnosis was obtained even after bronchoscopy, including transbronchial needle aspiration biopsy, but large-cell carcinoma of the lung was diagnosed on the basis of ultrasound-guided biopsy of a shadow in the liver suspected of being a metastatic tumor (T2N3M1, Stage IV).
  • Two courses of chemotherapy (CBCDA + VDS) failed to gain any improvement, and the pain resulting from recurrent bone metastases was managed mainly by the administration of the best supportive care.
  • The patient was readmitted to the hospital after development of numbness in the right upper extremity followed by complication of pneumonia and heart failure, and he passed away.
  • Autopsy revealed a primary hilar lung tumor with a histological diagnosis of poorly differentiated adenocarcinoma.
  • [MeSH-minor] Aged. Bone Neoplasms / secondary. Cell Differentiation. Diagnosis, Differential. Humans. Liver Neoplasms / secondary. Lymphatic Metastasis. Male. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 11192985.001).
  • [ISSN] 0022-9717
  • [Journal-full-title] The Keio journal of medicine
  • [ISO-abbreviation] Keio J Med
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article
  • [Publication-country] Japan
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4. Rosell R, Green M, Gumerlock P: Advances in the treatment of non-small cell lung cancer: Molecular markers take the stage. Semin Oncol; 2001 Feb;28 Suppl 2:28-34
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  • [Title] Advances in the treatment of non-small cell lung cancer: Molecular markers take the stage.
  • Increasing evidence that non-small cell lung cancer is a systemic disease from the outset confirms the rationale for adjuvant chemotherapy.
  • The position is clearer in the case of neoadjuvant therapy because long-term follow up of two trials now shows that patients randomized to chemotherapy before surgery were significantly more likely to survive to 5 years than patients treated with surgery alone.
  • Early data suggest that neoadjuvant chemotherapy based on docetaxel (Taxotere; Aventis, Antony, France) (possibly used sequentially with other agents) may be as effective as older regimens and better tolerated.
  • Because p53 status influences the expression of microtubule-associated proteins and hence the sensitivity of a tumor to taxanes, it is possible that molecular markers could be used to customize chemotherapy to individual patients.
  • Generally, it is becoming clearer that molecular staging is a more sensitive means of demonstrating tumor dissemination than light microscopy.
  • The Cancer and Leukemia Group B is undertaking a prospective study using reverse transcriptase-polymerase chain reaction to detect MUC-I RNA in bone marrow and hilar and mediastinal lymph nodes removed at resection with the aim of distinguishing between stage I patients likely to remain disease-free for long periods and those at high risk of relapse.
  • A study of small cell lung cancer is using automated fluorescence microscopy to detect keratin-positive cells in the marrow and blood of patients who have a complete response to initial therapy but are nevertheless at high overall risk of relapse.
  • The identification of genetic lesions in a high proportion of patients with non-small cell lung cancer may guide the development of new therapies aimed at increasing rates of apoptosis among tumor cells.

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  • (PMID = 28140079.001).
  • [ISSN] 1532-8708
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Tokuyasu H, Izumi H, Mukai N, Takeda K, Sakaguchi Y, Isowa N, Shimizu E: Small cell lung cancer complicated by pulmonary sarcoidosis. Intern Med; 2010;49(18):1997-2001
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  • [Title] Small cell lung cancer complicated by pulmonary sarcoidosis.
  • In July 2009, a 69-year-old man was admitted to our hospital because an abnormal chest shadow had been noted on medical examination.
  • Chest radiography and computed tomography showed mediastinal and bilateral hilar lymphadenopathy.
  • Histological examination of the biopsy specimens obtained from the tumor in the left upper bronchus revealed small cell lung cancer, whereas examination of the specimens obtained from the left B(3) revealed noncaseating epithelioid cell granulomas containing giant cells, confirming the diagnosis of sarcoidosis.
  • The patient underwent chemotherapy with carboplatin and etoposide without any steroids.
  • After 4 courses of chemotherapy, bronchoscopic examination revealed that the tumor had shrunk, and the BALF CD4/CD8 ratio had decreased; further, no histological evidence of sarcoidosis was seen in specimens obtained from the left B(3).
  • Concomitant small cell lung cancer and sarcoidosis is rare.
  • Interestingly, cancer chemotherapy might improve pulmonary sarcoidosis.
  • [MeSH-major] Lung Neoplasms / complications. Lung Neoplasms / diagnosis. Sarcoidosis, Pulmonary / complications. Sarcoidosis, Pulmonary / diagnosis. Small Cell Lung Carcinoma / complications. Small Cell Lung Carcinoma / diagnosis
  • [MeSH-minor] Aged. Humans. Male

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  • (PMID = 20847506.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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6. Ishiguro T, Takayanagi N, Kurashima K, Matsushita A, Harasawa K, Yoneda K, Tsuchiya N, Miyahara Y, Yamaguchi S, Yano R, Tokunaga D, Saito H, Ubukata M, Yanagisawa T, Sugita Y, Kawabata Y: Development of sarcoidosis during etanercept therapy. Intern Med; 2008;47(11):1021-5
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  • [Title] Development of sarcoidosis during etanercept therapy.
  • This report describes a 65-year-old woman who developed granulomatous lesions consistent with sarcoidosis during etanercept therapy for rheumatoid arthritis.
  • Hilar and mediastinal lymphadenopathy and multiple nodules in both lung fields developed 21 months after administration of etanercept.
  • Noncaseating epithelioid cell granulomas consistent with sarcoidosis were detected in a lung biopsy specimen and in the parietal pleura obtained via thoracotomy.
  • There is substantial evidence of tumor necrosis factor-alpha involvement in the induction and maintenance of granuloma formation; however, we should keep in mind that granulomatous disease, such as sarcoidosis, can develop during treatment with a tumor necrosis factor-alpha blocking agent, such as etanercept.
  • [MeSH-minor] Aged. Arthritis, Rheumatoid / drug therapy. Etanercept. Female. Humans. Receptors, Tumor Necrosis Factor. Tomography, X-Ray Computed. Tumor Necrosis Factor-alpha / antagonists & inhibitors

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  • [CommentIn] Intern Med. 2008;47(18):1635 [18797127.001]
  • (PMID = 18520114.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antirheumatic Agents; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; OP401G7OJC / Etanercept
  • [Number-of-references] 21
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7. Kinoshita T, Inoue H, Kinouchi T, Kobayashi M, Takada T, Hara T, Hatano K, Nonomura N: Preoperative induction with sorafenib pathologically downstaged advanced renal cell carcinoma: a case report. Int J Urol; 2010 Mar;17(3):286-8
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  • [Title] Preoperative induction with sorafenib pathologically downstaged advanced renal cell carcinoma: a case report.
  • We present the case of a patient with renal cell carcinoma treated preoperatively with sorafenib.
  • Complete resection of the left renal mass measuring 7.2 x 6.6 cm seemed to be difficult at diagnosis because of large renal hilar lymph nodes.
  • With a short period of sorafenib administration, marked shrinkage of the renal mass and lymphadenopathy was observed after the patient experienced fulminant hepatic failure and a severe hand-foot skin reaction.
  • Two-dimensional computed tomography revealed 60%, 78% and 84% reduction in the primary renal tumor, lung metastatic nodules and lymph nodes, respectively.
  • Tumor shrinkage allowed for complete resection of the left kidney and the lymphadenopathy.
  • Pathological findings revealed that over 90% of the renal tumor was substituted by necrotic fibrotic tissue and that the residual neoplastic component was diagnosed as clear cell carcinoma.
  • The lymph nodes that were resected were negative for malignancy.
  • At 6 months after radical nephrectomy, a new computed tomography scan revealed no evidence of disease with the disappearance of lung nodules.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Benzenesulfonates / administration & dosage. Carcinoma, Renal Cell / drug therapy. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / drug therapy. Kidney Neoplasms / surgery. Pyridines / administration & dosage
  • [MeSH-minor] Aged, 80 and over. Combined Modality Therapy. Female. Humans. Nephrectomy. Niacinamide / analogs & derivatives. Phenylurea Compounds. Preoperative Care. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 20409221.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Phenylurea Compounds; 0 / Pyridines; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
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8. Tamura M, Doba S, Funaki K, Sasaki S, Michiwa Y, Kurosaka Y, Takekawa S, Kiriyama M, Kojima Y, Kita T, Kawashima A: [A case of non-small cell lung cancer in which complete response was achieved with chemotherapy including cisplatin, vinorelbine, mitomycin C, followed by additional cisplatin, etoposide and concurrent radiotherapy]. Gan To Kagaku Ryoho; 2006 Nov;33(11):1611-4
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  • [Title] [A case of non-small cell lung cancer in which complete response was achieved with chemotherapy including cisplatin, vinorelbine, mitomycin C, followed by additional cisplatin, etoposide and concurrent radiotherapy].
  • A 43-year-old man presented at our hospital with a complaint of cough and sputum.
  • A plain chest X-ray and CT scan revealed a tumor shadow 8 cm in size in the right hilar and enlarged mediastinal lymph node.
  • The tumor had invaded the superior vena cava.
  • A tumor biopsy done under bronchoscopy revealed poorly-differentiated adenocarcinoma (cT4N2M0).
  • He was given three courses of a combination therapy consisting of cisplatin (80 mg/m(2)), vinorelbine (25 mg/m(2)) and mitomycin C (8 mg/m(2)).
  • Additionally, concurrent chemoradiotherapy (cisplatin 80 mg/m(2)+etoposide 100 mg/m(2), and 45 Gy) was performed.
  • Right pneumonectomy was performed, because the primary tumor and the enlarged lymph node were markedly reduced in size, and a histological examination of the resected specimen revealed no detectable cancer cells.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Etoposide / administration & dosage. Humans. Male. Mitomycin / administration & dosage. Neoplasm Staging. Pneumonectomy. Remission Induction. Vinblastine / administration & dosage. Vinblastine / analogs & derivatives

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  • (PMID = 17108727.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; Q6C979R91Y / vinorelbine
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9. Morita M, Toyoshima H, Iino K, Tomita K, Sasaki H: [A case of multidrug-resistant squamous cell lung carcinoma responding to S-1 plus CPT-11 combination chemotherapy]. Gan To Kagaku Ryoho; 2008 Mar;35(3):479-82
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  • [Title] [A case of multidrug-resistant squamous cell lung carcinoma responding to S-1 plus CPT-11 combination chemotherapy].
  • The patient was a 63-year-old man who consulted our hospital with complaints of a cough and breathing difficulties.
  • His chest CT revealed a 25-mm mass in his right S1 hilar area with spiculation, disseminated nodule in right lung, and pericardial effusions.
  • Also, bronchoscope and TBLB revealed squamous cell carcinoma.
  • This patient was diagnosed as lung cancer (cT4N3M1, stage IV), and chemotherapy was initiated.
  • The chemotherapy was given in the order of CBDCA (AUC3) +GEM (1,000 mg/m(2)), DOC (60 mg/m(2)), and VNR (25 mg/m(2)), and the tumor response was PD.
  • S- 1 (120 mg/body/day, continuous administration for 2 weeks followed by 1 week of rest) was chosen as fourth-line treatment, and a breast CT detected tumor size reduction following completion of the first course.
  • However, after completion of three courses, the breast CT found tumor-enlargement again.
  • Then the chemotherapy was changed to amrubicin (35 mg/m(2)), but the treatment was discontinued due to skin rash.
  • We once experienced a size reduction with S-1, so S-1 (100 mg/body/day, day 1-14) plus CPT-11 (60 mg/m(2), day 1, 7, 14) combination chemotherapy was conducted at 4-week intervals.
  • After two courses were completed, tumor size reduction was observed by breast XP and CT.
  • Currently, seven courses were completed, and we will continue this treatment due to the tumor response of SD.
  • The S-1 single treatment and S-1+CPT-11 combination chemotherapy showed efficacy for this difficult case of NSCLC with refractoriness to multiple cancer drug chemotherapy.
  • This combination treatment should be investigated further for its therapeutic benefit.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Carcinoma, Squamous Cell / drug therapy. Drug Resistance, Neoplasm / drug effects. Lung Neoplasms / drug therapy. Oxonic Acid / therapeutic use. Tegafur / therapeutic use
  • [MeSH-minor] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Drug Combinations. Humans. Keratin-19. Keratins / blood. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18347399.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Drug Combinations; 0 / Keratin-19; 0 / antigen CYFRA21.1; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 68238-35-7 / Keratins; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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10. Ishida M, Nakama T, Shimazaki T, Tanaka T, Tsuchihashi Y, Morimoto K: [An autopsied case of pulmonary clear cell adenocarcinoma]. Nihon Kokyuki Gakkai Zasshi; 2010 May;48(5):364-9
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  • [Title] [An autopsied case of pulmonary clear cell adenocarcinoma].
  • We report a case of a 72-year-old woman who died of primary lung clear cell adenocarcinoma.
  • She visited our hospital with complaining of hemoptysis lasting for a month.
  • Chest X-ray films showed obstructive pneumonia in the left lower lobe.
  • Chest computed tomography (CT) showed a tumor shadow and collapsed portion in the left hilar area.
  • Sputum cytology and further diagnostic tests revealed stage IV lung adenocarcinoma.
  • Chemotherapy with carboplatin and paclitaxel was initiated, but no improvement was obtained.
  • They were immunocytochemically stained with cytokeratin 7 but not with cytokeratin 20.
  • According to previous reports in the literature, cases of primary lung clear cell adenocarcinoma are very rare.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Lung Neoplasms / pathology

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  • (PMID = 20560438.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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11. Murphy AM, McKiernan JM: Reoperative retroperitoneal lymph-node dissection for testicular germ cell tumor. World J Urol; 2009 Aug;27(4):501-6
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  • [Title] Reoperative retroperitoneal lymph-node dissection for testicular germ cell tumor.
  • METHODS: A PubMED and Medline search was performed to identify reoperative retroperitoneal surgery series for patients with nonseminomatous germ cell tumor.
  • RESULTS: A reliance on cisplatin-based chemotherapy to treat residual disease after RPLND is inadequate for most patients.
  • The left para-aortic and left renal hilar regions are the most common sites of retroperitoneal failure.
  • Clinical outcomes after reoperative RPLND are influenced by serum tumor markers, histologic findings and completeness of surgical resection.
  • CONCLUSIONS: Overall survival rates in men requiring redo RPLND appear significantly lower than similar patients who are successfully treated with their initial RPLND.
  • [MeSH-major] Lymph Node Excision / methods. Neoplasms, Germ Cell and Embryonal / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Humans. Male. Neoplasm Metastasis / prevention & control. Reoperation / methods. Retroperitoneal Neoplasms / secondary. Retroperitoneal Neoplasms / surgery

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  • (PMID = 19636565.001).
  • [ISSN] 1433-8726
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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12. Chen D, Zhang X, Yin W, Sun Y, Miao Y, Feng F, Wang J, Wang M, Zhang H, Feng Q, Xu B, Shi Y: [Results of combined therapy for 1260 patients with small cell lung cancer]. Zhonghua Zhong Liu Za Zhi; 2002 Nov;24(6):602-4
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  • [Title] [Results of combined therapy for 1260 patients with small cell lung cancer].
  • OBJECTIVE: To evaluate the efficacy of combined modality treatment and determine the prognostic factors for small cell lung cancer (SCLC).
  • METHODS: From January 1974 to December 1995, 1260 patients with SCLC treated were retrospectively evaluated, with limited lesions in 732 patients, extensive lesions in 500 and stage unrecorded in 28.
  • 553 patients were alloted into chemotherapy + radiotherapy (C + R) group, 355 into C + R + C group, 97 into R + C group, 126 into C group, 64 into R group and 65 into surgery (S + C + R) group.
  • Patients with limited lesions received 2 - 4 cycles of chemotherapy including COMC, COMP, COMVP and CE-CAP.
  • Radiotherapy was given to a dose of 40 - 70 Gy/4 - 7 w.
  • Radiation portals for patients with limited lesions encompassed the primary tumor, hilar lymphatic drainage areas, partial mediastinum and bilateral supraclavicular regions.
  • Patients with extensive lesions mainly received chemotherapy with or without palliative irradiation.
  • Local recurrence and distant metastasis rates were 58.8% and 61.5%.
  • The 1-, 3- and 5-year survival rates were 50.2%, 14.7% and 11.7%, with median survival time of 12 months.
  • The era, sex, age, tumor stage and treatment modality were all significant prognostic factors by both uni-variate and multi-variate analyses (P < 0.05).
  • The result of S + C + R rated the best among these modalities and the result of C + R + C was superior to C + R, though the difference of which was not significant.
  • CONCLUSION: Surgical resection should be considered as one part of comprehensive therapy for small cell lung cancer patients with limited lesions whenever possible.
  • On top of routine chemotherapy early administration of radiotherapy is advisable.
  • [MeSH-major] Carcinoma, Small Cell / therapy. Lung Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Radiotherapy. Survival Rate. Treatment Outcome

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  • (PMID = 12667336.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Sueda K, Ikenaga M, Miyazaki M, Yasui M, Mishima H, Tsujie M, Omiya H, Miyamoto A, Hirao M, Takami K, Fujitani K, Nakamori S, Yoshida K, Tsujinaka T: [A case of squamous cell carcinoma of the anal cancer with associated human immunodeficiency virus]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2656-8
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  • [Title] [A case of squamous cell carcinoma of the anal cancer with associated human immunodeficiency virus].
  • A 62-year-old man with internal piles tested positive for infection with HIV and was admitted to our hospital.
  • He presented with an anal tumor with bilateral inguinal nodal metastasis and pain in the anus; the tumor was diagnosed as stage IIIb (cA1N2M0).
  • However, CT performed 2 years after the diagnosis showed a recurrence in the hilar and mediastinal lymph node.
  • The patient was administered chemotherapy with 5-fluorouracil and cisplatin (5-FU/CDDP) to the metastatic lymph node.
  • However, the treatment response was graded as progressive disease, and the treatment was changed from CDDP to mitomycin C (MMC).
  • The patient developed non-hematologic toxicity and died within 3 years of the diagnosis.
  • We report a case of squamous cell carcinoma of the anus with associated HIV infection.
  • [MeSH-major] Anus Neoplasms / complications. Anus Neoplasms / therapy. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / therapy. HIV Seropositivity / complications
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents / administration & dosage. Antineoplastic Combined Chemotherapy Protocols. Antiretroviral Therapy, Highly Active. Cisplatin / administration & dosage. Combined Modality Therapy. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Mitomycin / administration & dosage


14. Hasturk S, Soylu M, Zeren EH, Hanta I: Basaloid large cell lung carcinoma presenting concurrently with metastatic uveal tumor. Lung Cancer; 2001 Apr;32(1):95-101
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  • [Title] Basaloid large cell lung carcinoma presenting concurrently with metastatic uveal tumor.
  • A 51-year-old man complaining of cough, hemoptysis, and decreased visual acuity was admitted to our hospital.
  • Chest radiography revealed a left hilar mass and pleural effusion in the left hemithorax.
  • In his ophtalmological examination, there was total retinal detachment in the left eye.
  • Ultrasonographic examination and orbital magnetic resonance imaging (MRI) were reported as choroidal metastasis.
  • A computed tomography (CT) confirmed the mass in the left hilum and multiple mass lesions consistent with metastasis in the liver and in the body of 12th thoracic vertebra.
  • Bronchoscopic biopsies revealed large cell carcinoma with basaloid features.
  • He died after 4 months with rapid progression of the disease in spite of combined chemotherapy.
  • Although primary lung cancer with concurrent eye metastasis is an uncommon entity, it should always be kept in mind for patients with ocular symptoms.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Large Cell / secondary. Lung Neoplasms / pathology. Uveal Neoplasms / pathology. Uveal Neoplasms / secondary
  • [MeSH-minor] Carboplatin / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Paclitaxel / therapeutic use. Pleural Effusion, Malignant / pathology. Smoking / adverse effects. Tomography

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  • (PMID = 11282434.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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15. Shimizu K, Watanabe E, Hamanaka S, Onuma S, Nakano M, Yamazaki T, Higa M, Yamamuro W, Kiguchi E: [A case of non-small-cell lung cancer successfully treated using combination chemotherapy with CDDP and vinorelbine]. Gan To Kagaku Ryoho; 2000 Sep;27(10):1565-8
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  • [Title] [A case of non-small-cell lung cancer successfully treated using combination chemotherapy with CDDP and vinorelbine].
  • A 67-year-old woman presented to our hospital with a chief complaint of bloody sputum.
  • A plain chest X-ray a CT scan revealed a tumor shadow 3 cm in size in the middle lobe of the right lung, multiple nodular shadows in the bilateral lung fields and enlarged hilar and mediastinal lymph nodes.
  • A tumor biopsy done under bronchoscopy revealed poorly differentiated adenocarcinoma of the lungs (cT2N3M1).
  • She was given two courses of combination therapy consisting of cisplatin (80 mg/m2) and vinorelbine (20 mg/m2).
  • The primary tumor in the middle lobe of the right lung and the lung metastases were markedly reduced in size, and a complete response was obtained.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy
  • [MeSH-minor] Aged. Cisplatin / administration & dosage. Drug Administration Schedule. Female. Humans. Vinblastine / analogs & derivatives

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  • (PMID = 11016002.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin
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16. Seok JY, Lee KG: Cytologic features of metastatic lymphoepithelial carcinoma in pleural fluid: a case report. Acta Cytol; 2009 Mar-Apr;53(2):215-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic features of metastatic lymphoepithelial carcinoma in pleural fluid: a case report.
  • BACKGROUND: Lymphoepithelial carcinoma of the salivary gland is a rare undifferentiated or poorly differentiated squamous cell carcinoma associated with abundant inmphocytes.
  • Only a handful of reports descibe the cytologic features of fine needle aspiration in lymphoepithelial carcinoma of the salivary gland and lymph nodes.
  • CASE: A 29-year-old man presented with a painless mass in his right parotid gland.
  • After the surgical specimen was evaluated, the mass was diagnosed as a lymphoepithelial carcinoma, which extended to the periglandular soft tissue with lymph node metastasis.
  • Despite radiation and chemotherapy, multiple mediastinal lymph node metastases, including in the right hilar lymph nodes, occurred.
  • Pulmonary atelectasis of the right upper lobe and a right pleural effusion developed.
  • Aspiration cytology of metastatic lymph nodes and pleural effusion cytology both demonstrated strongly cohesive clusters of tumor cells.
  • CONCLUSION: Pleural effusion cytopathology ofmetastatic lymphoepithelial carcinoma is similar to that of primary tumor fine needle aspiration.
  • Therefore, a specific diagnosis of lymphoepithelial carcinoma is possible on the basis of body fluid with these cytologic features.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Parotid Neoplasms / pathology. Pleural Effusion, Malignant / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Humans. Lymphatic Metastasis / pathology. Male. Pulmonary Atelectasis / etiology

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  • (PMID = 19365979.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Ohyama S, Hatachi Y, Ueda T, Nakata M, Taniguchi M, Hasegawa Y, Murayama T, Bando K: [An elderly patient with advanced non-small-cell lung cancer that responded remarkably to combination chemotherapy of vinorelbine and gemcitabine]. Gan To Kagaku Ryoho; 2002 Mar;29(3):439-42
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  • [Title] [An elderly patient with advanced non-small-cell lung cancer that responded remarkably to combination chemotherapy of vinorelbine and gemcitabine].
  • A 73-year-old man was admitted to our hospital because of hemoptysis in November 1999.
  • A chest CT revealed a mass shadow in the right upper lobe and enlarged hilar and pretracheal lymph nodes.
  • Bone scintigraphy showed a bone metastasis in right middle rib.
  • After 4 courses of chemotherapy, the primary tumor and hilar lymph node were remarkably reduced in size, and his hemoptysis disappeared and body weight increased.
  • It is suggested that combination chemotherapy with vinorelbine and gemcitabine is effective for elderly patients with non-small-cell lung cancer with good performance status.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Deoxycytidine / analogs & derivatives. Lung Neoplasms / drug therapy. Vinblastine / analogs & derivatives
  • [MeSH-minor] Aged. Drug Administration Schedule. Humans. Male. Quality of Life

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  • (PMID = 11915736.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 5V9KLZ54CY / Vinblastine; B76N6SBZ8R / gemcitabine; Q6C979R91Y / vinorelbine
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18. Berr F, Tannapfel A, Lamesch P, Pahernik S, Wiedmann M, Halm U, Goetz AE, Mössner J, Hauss J: Neoadjuvant photodynamic therapy before curative resection of proximal bile duct carcinoma. J Hepatol; 2000 Feb;32(2):352-7
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  • [Title] Neoadjuvant photodynamic therapy before curative resection of proximal bile duct carcinoma.
  • BACKGROUND: Hilar bile duct carcinoma has an 80% probability of local recurrence after curative resection, which might be reduced if neoadjuvant photodynamic therapy is feasible.
  • CASE AND TREATMENT: After intravenous injection of sodium porfimer we treated an adenocarcinoma of the proximal common bile duct (T2 N0 M0, Bismuth type II) in a 72-year-old man with red laser light (applied from the lumen at a dose 250 Joules/cm2), and the adjacent right and left hepatic and common bile duct at a dose of 125 Joules/cm2.
  • After 23 days the tumor was completely resected (adenocarcinoma pT2 pNO; G2).
  • RESULTS: In the lumenal, 4-mm-thick layer the bile duct specimen exhibited complete tumor necrosis with pigmentation of photodegraded porfimer and no viable tumor cells, while in the outer layer of the wall (at 5-8-mm depth) viable cancer cell nests without degraded porfimer were seen.
  • The bile duct tissue showed little damage.
  • Eighteen months after surgery, neither tumor recurrence nor stricture formation was found at the pretreated bilioenteric anastomoses.
  • CONCLUSIONS: a) Photodynamic therapy with sodium porfimer seems to be confined to the superficial 4-mm layer of bile duct cancer.
  • b) Neoadjuvant photodynamic therapy is feasible for hilar bile duct carcinoma.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Bile Duct Neoplasms / drug therapy. Bile Duct Neoplasms / surgery. Common Bile Duct. Neoadjuvant Therapy. Photochemotherapy
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Cholangiopancreatography, Endoscopic Retrograde. Combined Modality Therapy. Dihematoporphyrin Ether / therapeutic use. Feasibility Studies. Humans. Injections, Intravenous. Male

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  • (PMID = 10707878.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] DENMARK
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 97067-70-4 / Dihematoporphyrin Ether
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19. Minami S, Komuta K, Asai M: [A case of amylase-producing lung cancer]. Nihon Kokyuki Gakkai Zasshi; 2003 Oct;41(10):717-21
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  • [Title] [A case of amylase-producing lung cancer].
  • A 72-year-old man was admitted to our hospital because of progressive dyspnea due to pulmonary emphysema.
  • Chest CT revealed a nodular lesion in the right S6 and swollen right hilar lymph nodes.
  • The diagnosis was not confirmed bronchoscopically.
  • A subsequent biopsy of a subcutaneous mass in the left lateral pectoral region demonstrated metastatic cancer.
  • Laboratory data on admission showed marked elevation of amylase activity in both serum and urine.
  • Amylase isozyme patterns identified the salivary types.
  • The pancreas and salivary glands were unlikely to have any clinical involvement in the hyperamylasemia, but lung cancer with subcutaneous metastasis was strongly suspected clinically as the source.
  • Chemotherapy failed to prevent tumor progression and the patient eventually died of respiratory failure.
  • Immunohistological examination of the subcutaneous lesion showed positive staining for salivary-type amylase, whereas that of the lung primary lesion disclosed small cell carcinoma and negative staining for amylase.
  • Amylase-producing small cell carcinoma is very rare.
  • [MeSH-major] Amylases / biosynthesis. Carcinoma, Small Cell / enzymology. Lung Neoplasms / enzymology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Fatal Outcome. Humans. Isoenzymes / analysis. Isoenzymes / biosynthesis. Male. Neoplasms, Connective Tissue / secondary. Subcutaneous Tissue

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  • (PMID = 14584392.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; EC 3.2.1.- / Amylases
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20. Shimamura M, Yamaguchi S, Kuroiwa Y: [A Lambert-Faton myasthenic syndrome and subacute cerebellar degeneration with a favorable clinical course after resection of small-cell lung cancer]. Rinsho Shinkeigaku; 2000 Oct;40(10):1028-32
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  • [Title] [A Lambert-Faton myasthenic syndrome and subacute cerebellar degeneration with a favorable clinical course after resection of small-cell lung cancer].
  • A case of Lambert-Eaton myasthenic syndrome (LEMS) and subacute cerebellar degeneration (SCD) was associated with small-cell lung cancer (SCLC).
  • The patient, a 52-year-old man, who had noticed impotence one year previously, began to have ataxic gait, scanning speech and thirst progressing for 3 months, followed by weakness of the lower limbs, bilateral blepharoptosis, and double vision.
  • Electromyographic studies showed low amplitude of compound muscle action potential (CMAP) and waxing phenomenon in high frequency stimulation of the ulnar nerve.
  • A chest x-ray showed a mass lesion in the left hilar region, and small cell lung cancer was diagnosed on the basis of biopsy specimens.
  • The patient was treated by lobectomy and chemotherapy, which resulted in improvement in the LEMS and SCD.
  • But we propose that anti-neoplastic treatment including resection of the tumor is the first choice for the treatment of paraneoplastic syndrome associated with SCLC.
  • [MeSH-major] Carcinoma, Small Cell / surgery. Lambert-Eaton Myasthenic Syndrome / therapy. Lung Neoplasms / surgery. Paraneoplastic Cerebellar Degeneration / therapy
  • [MeSH-minor] Autoantibodies / analysis. Calcium Channels / immunology. Humans. Male. Middle Aged


21. Wakahashi K, Shimoyama M, Katayama Y, Minagawa K, Yoshida K, Sasaki R, Nakayama S, Yokozaki H, Yanagita E, Itoh T, Hayashi Y, Matsui T: Histiocytic sarcoma with two immunohistopathologically distinct populations. Int J Hematol; 2010 Nov;92(4):642-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This report is a case of histiocytic sarcoma (HS), in which tumor cells consist of two immunohistopathologically distinct populations (A) oval CD68+lysozyme+CD163- cells and (B) abundant cytoplasm or spindle-shaped CD68+lysozyme-CD163+ cells.
  • Cervical lymph node was infiltrated mainly by population (A), where chemotherapy was quite effective.
  • On the other hand, vast majority of infiltrated tumor cells in the hilar lymph node belonged to population (B), in which the cells were resistant to chemo-radiotherapy.
  • It is also notable that CD163-negative stage of HS may exist and still be reactive for the treatment.
  • [MeSH-minor] Aged. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Cell Shape. Fatal Outcome. Humans. Lymph Nodes / chemistry. Lymph Nodes / metabolism. Lymph Nodes / pathology. Male. Muramidase / analysis. Receptors, Cell Surface / analysis

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  • (PMID = 20924729.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD163 antigen; 0 / CD68 antigen, human; 0 / Receptors, Cell Surface; EC 3.2.1.17 / Muramidase
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22. Yamaguchi H, Soda H, Kitazaki T, Nakano H, Fujino S, Nakamura Y, Kohno S: Serum progastrin-releasing peptide levels followed by whole-body positron emission tomography detects early recurrence of small-cell lung cancer. Respirology; 2007 Jan;12(1):137-9
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  • [Title] Serum progastrin-releasing peptide levels followed by whole-body positron emission tomography detects early recurrence of small-cell lung cancer.
  • A 65-year-old male smoker with severe COPD was diagnosed with limited-stage small-cell lung cancer.
  • A whole-body 18F-fluorodeoxyglucose PET (FDG-PET) scan confirmed complete remission.
  • During follow up, serum ProGRP levels increased, and a whole-body FDG-PET scan detected recurrence at the hilar lymph node that had been negative on CT.
  • Complete remission was again achieved with second-line chemotherapy (cisplatin/etoposide) and local irradiation to the hilar lymph node.
  • Monitoring serum ProGRP levels, followed by whole-body FDG-PET when indicated, may improve the clinical management of patients with small-cell lung cancer after initial complete remission.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Small Cell. Lung Neoplasms. Neoplasm Recurrence, Local. Peptide Fragments / blood. Peptides / blood. Positron-Emission Tomography / methods
  • [MeSH-minor] Aged. Disease Progression. Fatal Outcome. Humans. Male. Recombinant Proteins / blood

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  • (PMID = 17207039.001).
  • [ISSN] 1323-7799
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Peptide Fragments; 0 / Peptides; 0 / Recombinant Proteins; 0 / pro-gastrin-releasing peptide (31-98)
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23. Benchekroun A, Zannoud M, el Alj HA, Nouini Y, Marzouk M, Faik M: [Clear cell sarcoma of the kidney: 3 case reports]. Prog Urol; 2002 Jun;12(3):469-73
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  • [Title] [Clear cell sarcoma of the kidney: 3 case reports].
  • [Transliterated title] Sarcome à cellules claires du rein (à propos de trois observations).
  • Clear cell carcoma of the kidney is a distinct, highly malignant pediatric neoplasm.
  • Its occurrence in adults is extremely rare and the subject of isolated case reports.
  • MATERIAL AND METHODS: We report 3 cases of clear cell sarcoma of the kidney in one men and two women between 23 and 65 years old (mean age is 40 years).
  • A radical nephrectomy with hilar lympgh node dissection was accomplished.
  • A combination chemotherapy regiment (cisplatin and doxorubicin) was performed on 6 cycles in 1 case.
  • The other 2 case was not underwent chemotherapy or radiation.
  • RESULTS: In the patient underwent the combination chemotherapy there was not evidence of tumor in the abdomen and thorax on CT Scan 4 years later.
  • In one of the two patient not underwent chemotherapy or radiation, the CT scan revealed a left psoas reccurrence three month later; therapy consisted for surgery without chemotherapy or radiation.
  • Four month later, tfe CT scan revealed a reccurrence in the left retroperitoneal region and liver and speen metastasis.
  • The patient was dead two month later.
  • The other patient not underwent chemotherapy or radiation was dead seven month after nephrectomy.
  • CONCLUSION: Optimal treatment is unknown, and surgery; radiotherapy and chemotherapy are used alone but mostly in combination.
  • [MeSH-major] Kidney Neoplasms. Sarcoma, Clear Cell
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Doxorubicin / administration & dosage. Fatal Outcome. Female. Humans. Male. Nephrectomy / methods

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  • (PMID = 12189758.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin
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24. Voutsas V, Mylonaki E, Gymnopoulos K, Kapetangiorgis A, Grigoriadis C, Papaemanuell S, Vafiadis E, Christaki P: Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. J Med Case Rep; 2008;2:270

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  • [Title] Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report.
  • CASE PRESENTATION: This case report describes the new onset of seizures in a 64-year-old male patient receiving chemotherapy for a diagnosed stage IV non-small cell lung carcinoma.
  • After three cycles of therapy, he was re-evaluated with a chest computed tomography which showed a 50% reduction in the tumor mass and in the size of the hilar and mediastinal lymphadenopathy.
  • Twenty days after the fourth cycle of chemotherapy, the patient was admitted to a neurological clinic because of the onset of self-limiting complex partial seizures, with motionless stare and facial twitching, but with no signs of secondary generalization.
  • The patient had also recently developed neurological symptoms of short-term memory loss and temporary confusion, and behavioral changes.
  • Based on the clinical picture, the patient's history of lung cancer, the brain magnetic resonance imaging findings and the results of the brain biopsy, we concluded that our patient had a 'definite' diagnosis of paraneoplastic limbic encephalitis and he was subsequently treated with a combination of chemotherapy and oral steroids, resulting in stabilization of his neurological status.
  • Despite the neurological stabilization, a chest computed tomography which was performed after the 6th cycle showed relapse of the disease in the chest.
  • CONCLUSION: Paraneoplastic limbic encephalitis is a rather rare cause of new onset of seizures in patients with non-small cell lung carcinoma.
  • Incidence, clinical presentation, laboratory evaluation, differential diagnosis, prognosis and treatment of this entity are discussed.

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  • [Cites] Orphanet J Rare Dis. 2007;2:22 [17480225.001]
  • [Cites] Oncologist. 2006 Mar;11(3):292-305 [16549814.001]
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  • (PMID = 18700972.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2526091
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25. Rosell R, Green M, Gumerlock P: Advances in the treatment of non-small cell lung cancer: molecular markers take the stage. Semin Oncol; 2001 Feb;28(1 Suppl 2):28-34
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  • [Title] Advances in the treatment of non-small cell lung cancer: molecular markers take the stage.
  • Increasing evidence that non-small cell lung cancer is a systemic disease from the outset confirms the rationale for adjuvant chemotherapy.
  • The position is clearer in the case of neoadjuvant therapy because long-term follow up of two trials now shows that patients randomized to chemotherapy before surgery were significantly more likely to survive to 5 years than patients treated with surgery alone.
  • Early data suggest that neoadjuvant chemotherapy based on docetaxel (Taxotere; Aventis, Antony, France) (possibly used sequentially with other agents) may be as effective as older regimens and better tolerated.
  • Because p53 status influences the expression of microtubule-associated proteins and hence the sensitivity of a tumor to taxanes, it is possible that molecular markers could be used to customize chemotherapy to individual patients.
  • Generally, it is becoming clearer that molecular staging is a more sensitive means of demonstrating tumor dissemination than light microscopy.
  • The Cancer and Leukemia Group B is undertaking a prospective study using reverse transcriptase-polymerase chain reaction to detect MUC-1 RNA in bone marrow and hilar and mediastinal lymph nodes removed at resection with the aim of distinguishing between stage I patients likely to remain disease-free for long periods and those at high risk of relapse.
  • A study of small cell lung cancer is using automated fluorescence microscopy to detect keratin-positive cells in the marrow and blood of patients who have a complete response to initial therapy but are nevertheless at high overall risk of relapse.
  • The identification of genetic lesions in a high proportion of patients with non-small cell lung cancer may guide the development of new therapies aimed at increasing rates of apoptosis among tumor cells.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Non-Small-Cell Lung / metabolism. Carcinoma, Non-Small-Cell Lung / therapy. Lung Neoplasms / metabolism. Lung Neoplasms / therapy. Neoplasm Proteins / metabolism. Paclitaxel / analogs & derivatives. Taxoids
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cell Cycle Proteins / metabolism. Clinical Trials as Topic. Combined Modality Therapy. Humans. Neoplasm Staging. Nuclear Proteins / metabolism. Proto-Oncogene Proteins / metabolism

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  • (PMID = 11284622.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / Taxoids; 15H5577CQD / docetaxel; P88XT4IS4D / Paclitaxel
  • [Number-of-references] 34
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26. Horikoshi M, Teshima T, Yanagimachi T, Imran MB, Nukiwa T: [Assessment of noninvasive therapy in lung cancer using lung perfusion images]. Kaku Igaku; 2000 Jan;37(1):15-22
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  • [Title] [Assessment of noninvasive therapy in lung cancer using lung perfusion images].
  • The purpose of this prospective study was to follow the changes in functional parameters of radionuclide lung perfusion scans and their role in prognostication of lung cancer cases after noninvasive therapy.
  • We studied 91 patients of lung cancer treated with chemotherapy and/or radiotherapy during 1993 to 1997 in our hospital.
  • Lung perfusion scans were acquired pre and post-therapy.
  • An index of lung perfusion, called Improvement Ratio (IR) was defined as a change in the perfusion of diseased lung as a result of treatment.
  • [formula: see text] where Q and Q' are pulmonary arterial blood flow pre and post therapy respectively, p is perfusion ratio of diseased lung before therapy and q is that after therapy.
  • We further studied the relationship between IR and change in tumor size.
  • The influence of tumor location, histopathological diagnosis and prognosis of lung cancer were correlated with this newly defined index.
  • IR in the group of patients with complete response or partial response was significantly higher than in those with poor response (2.72 +/- 0.78 versus 0.99 +/- 0.09, p < 0.05).
  • There was no statistical difference between the group with and without radiotherapy.
  • The score was significantly higher for patients with hilar disease compared to those with peripheral lesions (2.80 +/- 0.83 versus 1.02 +/- 0.03, p < 0.05).
  • Similarly, patients with small cell lung cancer depicted higher values of IR than non-small cell lung cancer (3.36 +/- 1.10 versus 1.06 +/- 0.07, p < 0.05).
  • All those subjects who showed IR > 1 had longer survival time than those with IR < 1 (p < 0.05).
  • We conclude that the evaluation of physiological parameters during therapy using lung perfusion scanning, in addition to lesion size assessment will contribute to the comprehensive follow-up of lung cancer.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 10714063.001).
  • [ISSN] 0022-7854
  • [Journal-full-title] Kaku igaku. The Japanese journal of nuclear medicine
  • [ISO-abbreviation] Kaku Igaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] JAPAN
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27. Vanneste BG, Haas RL, Bard MP, Rijna H, Váldes Olmos RA, Belderbos JS: Involved field radiotherapy for locally advanced non-small cell lung cancer: isolated mediastinal nodal relapse. Lung Cancer; 2010 Nov;70(2):218-20
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  • [Title] Involved field radiotherapy for locally advanced non-small cell lung cancer: isolated mediastinal nodal relapse.
  • The current standard of care for locally advanced inoperable non-small cell lung cancer is high dose radiotherapy with concurrent chemotherapy.
  • We report on a patient with stage IIIA NSCLC treated with concurrent chemoradiotherapy on the primary tumor and the 18-fluorodeoxyglucose positron emission tomography ((18)FDG-PET) positive hilar and mediastinal lymph nodes.
  • Six months after treatment this patient developed a single isolated contralateral mediastinal nodal relapse outside but in the proximity of the irradiated target volume.
  • This case describes the clinical problem of a regional recurrence after involved field radiotherapy that occasionally occurs.
  • A possible explanation for those regional recurrences is an under staging of extension of the disease because the time-interval between the staging (18)FDG-PET-CT scan and the start of the irradiation was too long.
  • If the time-interval is 4 weeks or more, we strongly recommend a new (18)FDG-PET-CT because of the possibility of upstaging of the disease.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / radiotherapy. Lung Neoplasms / radiotherapy. Lymph Nodes / pathology. Lymphatic Metastasis. Neoplasm Recurrence, Local
  • [MeSH-minor] Chemotherapy, Adjuvant. Clinical Protocols. Disease Progression. Disease-Free Survival. Humans. Male. Mediastinum / pathology. Middle Aged. Neoplasm Staging. Radiotherapy Dosage

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20832897.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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28. Fox J, Ford E, Redmond K, Zhou J, Wong J, Song DY: Quantification of tumor volume changes during radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys; 2009 Jun 1;74(2):341-8
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  • [Title] Quantification of tumor volume changes during radiotherapy for non-small-cell lung cancer.
  • PURPOSE: Dose escalation for lung cancer is limited by normal tissue toxicity.
  • We evaluated sequential computed tomography (CT) scans to assess the possibility of adaptively reducing treatment volumes by quantifying the tumor volume reduction occurring during a course of radiotherapy (RT).
  • METHODS AND MATERIALS: A total of 22 patients underwent RT for Stage I-III non-small-cell lung cancer with conventional fractionation; 15 received concurrent chemotherapy.
  • Two repeat CT scans were performed at a nominal dose of 30 Gy and 50 Gy.
  • The gross tumor volume (GTV) was delineated on simulation and all individual phases of the repeat CT scans.
  • Parenchymal tumor was evaluated unless the nodal volume was larger or was the primary.
  • The volume reduction was not significantly different between patients receiving chemoradiotherapy vs. RT alone, a GTV >100 cm(3) vs. <100 cm(3), and hilar and/or mediastinal involvement vs. purely parenchymal or pleural lesions.
  • A tendency toward a greater volume reduction with increasing dose was seen, although this did not reach statistical significance.
  • These observations raise the possibility of using an adaptive approach toward RT of non-small-cell lung cancer to minimize the dose to normal structures and more safely increase the dose directed at the target tissues.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / radiotherapy. Lung Neoplasms / radiotherapy. Tumor Burden / radiation effects
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy / methods. Humans. Radiotherapy Dosage. Tomography, X-Ray Computed

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  • (PMID = 19038504.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Ishimatsu Y, Takatani H, Doutsu Y, Mukae H, Kohno S: [A case of Heerfordt's syndrome with an elevated serum TNF alpha]. Nihon Kokyuki Gakkai Zasshi; 2006 Sep;44(9):636-40
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  • [Title] [A case of Heerfordt's syndrome with an elevated serum TNF alpha].
  • A 27-year old man who had developed uveitis, swelling of the right parotid gland, right facial nerve paralysis and fever, was admitted to our hospital.
  • A chest X-ray film showed bilateral hilar lymphadenopathy.
  • Histological findings of transbronchial lung biopsy specimens showed non-caseous epithelioid cell granulomas.
  • This case also fulfilled the criteria for Heerfordt's syndrome.
  • Thus, administration of high-dose PSL for a long time was required.
  • [MeSH-major] Anti-Inflammatory Agents / administration & dosage. Prednisolone / administration & dosage. Tumor Necrosis Factor-alpha / analysis. Uveoparotid Fever / blood. Uveoparotid Fever / drug therapy
  • [MeSH-minor] Adult. Humans. Male

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  • (PMID = 17037408.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Tumor Necrosis Factor-alpha; 9PHQ9Y1OLM / Prednisolone
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30. Kambayashi T, Ri M, Yanagihara K, Miyahara R, Bando T, Hasegawa S, Inui K, Wada H: [A case of endobronchial squamous cell lung cancer successfully treated with weekly chemotherapy of carboplatin and paclitaxel]. Gan To Kagaku Ryoho; 2003 Jun;30(6):841-4
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  • [Title] [A case of endobronchial squamous cell lung cancer successfully treated with weekly chemotherapy of carboplatin and paclitaxel].
  • A 69-year-old man had undergone low anterior resection and a right lobe resection of the liver for rectum cancer and metastatic liver tumor at the age of 66 years.
  • He presented at our hospital because of an abnormal shadow on a CT chest scan, which indicated a tumor shadow 2.5 cm in size in the lingular lobe and enlarged hilar and mediastinal lymph nodes.
  • A bronchoscopic tumor biopsy revealed pulmonary metastasis from the rectum cancer.
  • Bronchoscopic examination also identified an endobronchial squamous cell lung cancer, which almost completely obstructed the orifice of B1 and B2.
  • We concluded that the patient had squamous cell lung cancer with metastases in the mediastinal lymph nodes.
  • He was initially treated with weekly chemotherapy with carboplatin (AUC 1.25) and paclitaxel (70 mg/m2).
  • The endobronchial tumor was markedly reduced in size after 2 weeks of the chemotherapy.
  • Furthermore, after 6 weeks of the chemotherapy, the tumor had disappeared completely, and 11 days later, lower division segmentectomy and hilar and mediastinal lymph node dissection were performed.
  • Pathological examination revealed no metastases in the lymph nodes.
  • The patient has continued to receive chemotherapy as an outpatient and has been well without recurrence of any metastases for over 16 months.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bronchial Neoplasms / drug therapy. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy. Neoplasms, Multiple Primary / drug therapy
  • [MeSH-minor] Aged. Carboplatin / administration & dosage. Drug Administration Schedule. Humans. Lymphatic Metastasis. Paclitaxel / administration & dosage

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  • (PMID = 12852353.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
  • [Number-of-references] 8
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31. Hubbs JL, Boyd JA, Hollis D, Chino JP, Saynak M, Kelsey CR: Factors associated with the development of brain metastases: analysis of 975 patients with early stage nonsmall cell lung cancer. Cancer; 2010 Nov 1;116(21):5038-46
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  • [Title] Factors associated with the development of brain metastases: analysis of 975 patients with early stage nonsmall cell lung cancer.
  • BACKGROUND: The risk of developing brain metastases after definitive treatment of locally advanced nonsmall cell lung cancer (NSCLC) is approximately 30%-50%.
  • The risk for patients with early stage disease is less defined.
  • A multivariate analysis assessed factors associated with the development of brain metastases.
  • RESULTS: Of 975 consecutive patients, 85% were stage I, and 15% were stage II.
  • Adjuvant chemotherapy was given to 7%.
  • The 5-year actuarial risk of developing brain metastases and distant metastases was 10%(95% confidence interval [CI], 8-13) and 34%(95% CI, 30-39), respectively.
  • On multivariate analysis, younger age (hazard ratio [HR], 1.03 per year), larger tumor size (HR, 1.26 per cm), lymphovascular space invasion (HR, 1.87), and hilar lymph node involvement (HR, 1.18) were associated with an increased risk of developing brain metastases.
  • CONCLUSIONS: In this large series of patients treated surgically for early stage NSCLC, the 5-year actuarial risk of developing brain metastases was 10%.
  • A better understanding of predictive factors and biological susceptibility is needed to identify the subset of patients with early stage NSCLC who are at particularly high risk.
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / secondary. Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Cranial Irradiation. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Recurrence. Risk Factors


32. Leelawat K, Udomchaiprasertkul W, Narong S, Leelawat S: Induction of MKP-1 prevents the cytotoxic effects of PI3K inhibition in hilar cholangiocarcinoma cells. J Cancer Res Clin Oncol; 2010 Oct;136(10):1537-44
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  • [Title] Induction of MKP-1 prevents the cytotoxic effects of PI3K inhibition in hilar cholangiocarcinoma cells.
  • PURPOSE: Hilar cholangiocarcinoma (Klatskin tumor) is one of the most difficult cancers to treat.
  • We demonstrate activation of phosphoinositide-3-kinase (PI3K)/Akt signaling, which is a critical pathway for cell survival, in hilar cholangiocarcinoma cells.
  • However, inhibition of PI3K has little effect on hilar cholangiocarcinoma cell survival.
  • In this study, we investigated the mechanism by which hilar cholangiocarcinoma cells resist PI3K inhibitors.
  • METHODS: Human hilar cholangiocarcinoma cells KKU-100 were treated with PI3K inhibitors, and cell viability and apoptosis assays were performed.
  • The expression of a MAPK phosphatase (MKP-1) that contributes to cancer cell survival in response to multiple stress stimuli was assayed by quantitative real-time RT-PCR and western blotting.
  • Simultaneous targeting of the PI3K pathway and MKP-1 may be a useful approach to improve therapies directed against hilar cholangiocarcinoma.
  • [MeSH-major] Bile Duct Neoplasms / drug therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / drug therapy. Dual Specificity Phosphatase 1 / physiology. Phosphatidylinositol 3-Kinases / antagonists & inhibitors
  • [MeSH-minor] Cell Line, Tumor. Cell Survival / drug effects. Chromones / pharmacology. Cycloheximide / pharmacology. Humans. Morpholines / pharmacology. Phosphorylation. p38 Mitogen-Activated Protein Kinases / metabolism

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  • (PMID = 20145951.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chromones; 0 / Morpholines; 31M2U1DVID / 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 98600C0908 / Cycloheximide; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.1.3.48 / DUSP1 protein, human; EC 3.1.3.48 / Dual Specificity Phosphatase 1
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33. Pourel N, Santelmo N, Naafa N, Serre A, Hilgers W, Mineur L, Molinari N, Reboul F: Concurrent cisplatin/etoposide plus 3D-conformal radiotherapy followed by surgery for stage IIB (superior sulcus T3N0)/III non-small cell lung cancer yields a high rate of pathological complete response. Eur J Cardiothorac Surg; 2008 May;33(5):829-36
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  • [Title] Concurrent cisplatin/etoposide plus 3D-conformal radiotherapy followed by surgery for stage IIB (superior sulcus T3N0)/III non-small cell lung cancer yields a high rate of pathological complete response.
  • INTRODUCTION: Optimal preoperative treatment of stage IIB (Pancoast)/III non-small cell lung cancer (NSCLC) remains undetermined and a subject of controversy.
  • The goal of our study is to confirm feasibility and pathological response rates after induction chemoradiation (CRT) in our community-based treatment center.
  • Induction treatment comprised 3D conformal 4500 cGy radiotherapy delivered to the primary tumor and pathologic hilar and/or mediastinal lymph nodes on CT scan with an extra-margin of 1-1.5 cm.
  • Concurrent chemotherapy regimen was cisplatinum 20mg/m2 d1-d5 and etoposide 50mg/m2 d1-d5, d1-5 d29-33.
  • Inoperable pts were referred for a 20-25 Gy boost +/-1 extra-cycle of cisplatinum+etoposide.
  • RESULTS: From 1996 to 2005, 107 pts were initially selected for treatment and received induction chemoradiation (stage IIB-Pancoast 18, IIIA 58 and IIIB 31, squamous cell carcinoma 48%, adenocarcinoma 44%, large-cell undifferentiated carcinoma 14%).
  • After preoperative evaluation, 72 pts (67%) had a thoracotomy (pneumonectomy 21, lobectomy 45, bilobectomy 5) and all but one (unresectable tumor) had a macroscopic complete resection.
  • During the 3-month postoperative time, five patients (6.9%) died, four after pneumonectomy (right 3, left 1).
  • The analysis of tumoral samples showed a pathological complete response rate or microscopic residual foci of 39.5%.
  • Median follow-up time was 22.3 months (survivors: 36.8 months), 2-year and 3-year overall survival rates were 55% and 40%, respectively (median=26.7 months) for all the intention-to-treat population (n=107), 62% and 51% (median=36.5 months) for 71 resected pts, 41% and 16% for 36 non-resected pts (median=19.1 months).
  • On multivariate analysis, surgical resection and tumoral necrosis >50% (or pathological complete response) were the most pertinent predictive factors of the risk of death (hazard ratio=0.50 and 0.48, p=0.006 and 0.038, respectively).
  • CONCLUSION: Surgery was feasible after induction chemoradiation, particularly lobectomy in PS 0-1, stage IIB (Pancoast)/III NSCLC pts but pneumonectomy carries a high risk of postoperative death (particularly, right pneumonectomy).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Cisplatin / therapeutic use. Etoposide / therapeutic use. Lung Neoplasms / drug therapy. Radiotherapy, Conformal / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pneumonectomy. Proportional Hazards Models. Radiotherapy Dosage. Survival Rate. Treatment Outcome

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  • (PMID = 18367406.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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34. Kubota T, Ikezoe T, Harada R, Nakata H, Kobayashi M, Taguchi H: [Pancreatic metastasis from lung cancer: report of an autopsy case]. Nihon Kokyuki Gakkai Zasshi; 2003 Dec;41(12):917-21
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  • [Title] [Pancreatic metastasis from lung cancer: report of an autopsy case].
  • A 69 year-old man with abnormal lung shadows in the right lung field was admitted to our hospital.
  • A chest computed tomography (CT) scan showed a lung tumor with hilar and mediastinal lymph node swelling.
  • A CT scan of the abdomen demonstrated a solitary pancreatic head tumor with a diameter of 3 cm.
  • Pathological examination of a transbronchial biopsy specimen revealed squamous cell carcinoma (SCC) of the lung.
  • Since obstructive jaundice had progressed rapidly, the patient received endoscopic nasobiliary drainage (ENBD) and stent-drainage therapy prior to chemotherapy using gemcitabine.
  • However, he died 4 months later of respiratory failure and systemic candidiasis associated with progression of the cancer.
  • An autopsy was performed, and microscopic and immunohistochemical examination revealed that the pancreatic tumor was a metastasis from lung cancer.
  • To our knowledge, obstructive jaundice due to pancreatic metastasis from lung SCC, especially that preceding the advent of a clinical manifestation of primary lung cancer, has rarely been reported.
  • [MeSH-major] Carcinoma, Small Cell / secondary. Jaundice, Obstructive / pathology. Lung Neoplasms / pathology. Pancreatic Neoplasms / secondary
  • [MeSH-minor] Aged. Humans. Male


35. Smythe WR, American College of Chest Physicians: Treatment of stage I non-small cell lung carcinoma. Chest; 2003 Jan;123(1 Suppl):181S-187S
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of stage I non-small cell lung carcinoma.
  • The American Joint Committee on Cancer defines stage I non-small cell lung carcinoma (NSCLC) as consisting of patients with a T1 or T2 primary tumor designation and no evidence of hilar or mediastinal nodal disease (N0) or metastatic spread (M0).
  • Medically fit patients in this clinical stage category based on conventional staging techniques should be considered for aggressive local therapy, and curative treatment is possible.
  • Surgical resection is the accepted treatment for patients with this stage grouping, and full lobar or greater (lobectomy, pneumonectomy) rather than sublobar (wedge resection, segmentectomy) resection is strongly suggested.
  • There is insufficient data to suggest that one method of resection (open thoracotomy, minimally invasive techniques) is superior to another.
  • The performance of a systematic sampling or full mediastinal lymph node dissection may improve pathologic staging but is unproven therapeutically.
  • There are no data supporting the routine use of chemotherapy in an adjuvant or neoadjuvant setting; however, recent phase II data suggest that neoadjuvant chemotherapy is feasible and safe, and larger phase III trials are now evaluating this modality.
  • Primary radiation therapy should be considered for inoperable patients.
  • The use of neoadjuvant or adjuvant radiation therapy in patients with stage I NSCLC is of unproven benefit.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery
  • [MeSH-minor] Combined Modality Therapy / methods. Evidence-Based Medicine. Humans. Neoplasm Staging. Pneumonectomy / methods. Radiotherapy / methods

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  • (PMID = 12527578.001).
  • [ISSN] 0012-3692
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Guideline; Journal Article; Practice Guideline
  • [Publication-country] United States
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36. Tanaka K, Hara I, Takenaka A, Kawabata G, Fujisawa M: Incidence of local and port site recurrence of urologic cancer after laparoscopic surgery. Urology; 2008 Apr;71(4):728-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These included 162 radical prostatectomies, 67 radical nephrectomies, 20 partial nephrectomies, 45 nephroureterectomies, 5 retroperitoneal lymph node dissections of testicular cancers after chemotherapy, 3 radical cystectomies, and 2 other procedures.
  • RESULTS: Of the 304 patients with cancer, 4 (1.3%) developed a local recurrence, including after retroperitoneal lymph node dissection in 2 patients, radical nephrectomy in 1, and radical cystectomy in 1.
  • The histologic type of both testicular cancers was mixed germ cell tumor, with one occurring in a renal hilar lymph node and the other in a paraaortic lymph node and kidney.
  • The histologic type of the renal cell carcinoma was papillary renal cell carcinoma with sarcomatoid features (Stage pT3aN1), and it occurred in a retrocaval lymph node.
  • The histologic type of the bladder cancer was transitional cell carcinoma, Grade 3, Stage pT4aN0, and it presented as peritoneal carcinomatosis 11 months postoperatively.
  • CONCLUSIONS: The incidence of recurrence in our series was closely correlated with the range in previous reports.
  • However, two recurrences were found in 5 patients who had undergone retroperitoneal lymph node dissection for testicular cancer after chemotherapy.
  • [MeSH-major] Laparoscopy / adverse effects. Neoplasm Recurrence, Local / epidemiology. Neoplasm Seeding. Urologic Neoplasms / pathology. Urologic Neoplasms / surgery
  • [MeSH-minor] Follow-Up Studies. Humans. Incidence. Male. Retrospective Studies. Urologic Surgical Procedures / adverse effects

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  • (PMID = 18279936.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Yamane Y, Tumori M, Nishiki M, Yamauti M, Yoshida M, Maruyama R, Uchida N, Kitagaki H, Kato Y: [A case of large-cell lung cancer successfully treated with docetaxel in combination with carboplatin and radiotherapy]. Gan To Kagaku Ryoho; 2002 Jun;29(6):921-5
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  • [Title] [A case of large-cell lung cancer successfully treated with docetaxel in combination with carboplatin and radiotherapy].
  • A 64-year-old male was referred to our hospital in September, 2000 for further examination of an abnormal chest shadow discovered in a regular health check-up.
  • Chest X-P and CT revealed a large tumor in the left upper lobe, in association with hilar lymphadenopathy and costal invasion.
  • Serum CEA was increased, and lung biopsy revealed a large-cell carcinoma.
  • Radiation (total 48 Gy) and 3 courses of chemotherapy with docetaxel (60 mg/m2) in combination with carboplatin (AUC = 6,600 mg) resulted in a remarkable reduction in the size of the mass, to less than 50%, and normalized serum CEA.
  • Left upper lobectomy, lymphadenectomy and costectomy were performed.
  • However, no tumor cells were detectable in the ablative specimen pathologically.
  • These findings suggest the efficacy of chemoradiotherapy including docetaxel with carboplatin in patients with large-cell lung cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Large Cell / therapy. Lung Neoplasms / therapy. Paclitaxel / analogs & derivatives. Taxoids
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Carboplatin / administration & dosage. Combined Modality Therapy. Humans. Male. Middle Aged. Pneumonectomy

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  • (PMID = 12090045.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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38. Yamane Y, Tumori M, Nosaka S, Yamauti M, Tamura K, Kato Y: [A case of adrenal metastasis of lung cancer treated by carboplatin and docetaxel]. Gan To Kagaku Ryoho; 2001 Jun;28(6):835-8
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  • [Title] [A case of adrenal metastasis of lung cancer treated by carboplatin and docetaxel].
  • A 42-year-old male was referred to our hospital in October 1998, suffering from severe cough accompanied by repeated hemosputa.
  • Chest X-P and CT revealed a large tumor in the right upper lobe and hilar lymphadenopathy.
  • Abdominal CT revealed bilateral adrenal tumors.
  • For continuous bloody sputum, a right upper lobectomy and lymphadenectomy were performed and the pathologic diagnosis was large cell carcinoma.
  • After surgery, we chose radiation and chemotherapy.
  • The new chemotherapeutic agent docetaxel (60 mg/m2 in combination with carboplatin (CBDCA: AUC 6,800 mg/m2) was administered, resulting in the remarkable reduction in the size of adrenal metastasis by 50% after 3 courses of chemotherapy.
  • Furthermore, 12 months later, the right adrenal metastasis was remarkably reduced (5 x 3 cm-> 0.5 x 1.0 cm), and the left adrenal metastasis had disappeared on abdominal CT.
  • These findings may suggest the efficacy of newly developed docetaxel in cases of non-small cell lung cancer.
  • [MeSH-major] Adrenal Gland Neoplasms / drug therapy. Adrenal Gland Neoplasms / secondary. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carboplatin / administration & dosage. Carcinoma, Large Cell / drug therapy. Carcinoma, Large Cell / pathology. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology. Paclitaxel / administration & dosage. Paclitaxel / analogs & derivatives. Taxoids
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Male

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  • (PMID = 11432354.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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39. Ohno S, Takemasa A, Kawaguchi K, Teruuchi S, Saitoh N, Hasegawa T, Yamaguchi T, Sohara Y, Hironaka M, Sugiyama Y: [Induction chemotherapy (cisplatin + vinorelbine) is found to be markedly effective for squamous cell lung carcinoma with sarcoidosis--a case report]. Gan To Kagaku Ryoho; 2001 Feb;28(2):235-8
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  • [Title] [Induction chemotherapy (cisplatin + vinorelbine) is found to be markedly effective for squamous cell lung carcinoma with sarcoidosis--a case report].
  • A sixty-one-year-old man was admitted to our hospital because of a right lung tumor shadow.
  • He was newly diagnosed as having squamous cell carcinoma by trans bronchial biopsy.
  • He was treated with an induction chemotherapy (cisplatin 80 mg/m2 + vinorelbine 20 mg/m2) followed by right middle and lower lobectomy with a mediastinal nodal dissection, because the stage of his carcinoma was cT2N2M0.
  • Resected lung tissue showed the disappearance of cancer cells.
  • Dissected mediastinal and hilar lymph nodes showed many sarcoid granulomas.
  • Cisplatin combined with vinorelbine might be an effective chemotherapy for non-small cell lung carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Squamous Cell / therapy. Lung Neoplasms / therapy. Sarcoidosis / complications. Vinblastine / analogs & derivatives
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Humans. Male. Middle Aged

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  • (PMID = 11242653.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; Q6C979R91Y / vinorelbine
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