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1. Wolf R, Barzilai A, Davidovici B: Intertriginous lymphomatoid drug eruption. Int J Dermatol; 2010 Oct;49(10):1207-9
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  • [Title] Intertriginous lymphomatoid drug eruption.
  • A 76-year-old man developed a maculopapular purpuric eruption confined to the intertriginous areas (i.e. the inguinal, gluteal, and axillary folds).
  • Two days before the eruption appeared, he had received a second course of chemotherapy consisting of cisplatinum 40 mg and gemcitabine (Gemzar) 1700 mg for the treatment of squamous cell carcinoma of the lung stage III B.
  • The histologic picture was of either lymphomatoid drug eruption or lymphomatoid papulosis.
  • The antineoplastic therapy was changed to once-weekly intravenous vinorelbine (Navelbine) 50 mg, a Vinca alkaloid, and the eruption resolved completely within two weeks without any further therapy.
  • These circumstantial evidences support the diagnosis of intertriginous drug eruption.
  • Our case is interesting and unusual in that it demonstrated a rare clinical presentation of drug eruption, namely, intertriginous drug eruption or baboon syndrome, with a histologic picture of a lymphomatoid drug eruption that can mimic lymphoma.
  • We are unaware of any earlier reported case of baboon syndrome with a histologic picture of lymphomatoid drug eruption.
  • The pathomechanisms of both types of drug eruption, i.e. baboon syndrome and lymphomatoid drug eruption, are not fully understood.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Cisplatin / adverse effects. Deoxycytidine / analogs & derivatives. Intertrigo / chemically induced
  • [MeSH-minor] Aged. Humans. Lung Neoplasms / drug therapy. Male

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  • [Copyright] © 2009 The International Society of Dermatology.
  • (PMID = 20883412.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
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2. Perna AG, Jones DM, Duvic M: Lymphomatoid papulosis from childhood with anaplastic large-cell lymphoma of the small bowel. Clin Lymphoma; 2004 Dec;5(3):190-3
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  • [Title] Lymphomatoid papulosis from childhood with anaplastic large-cell lymphoma of the small bowel.
  • Lymphomatoid papulosis (LyP) is a lymphoproliferative disorder that exists on a spectrum of diseases with cutaneous CD30+ anaplastic large-cell lymphoma (ALCL).
  • Multiple treatment options are available, although none are curative.
  • The typical age of onset for LyP is in the third and fourth decades, but it has been seen occasionally in children.
  • Lymphomatoid papulosis is associated with primary cutaneous ALCL and other lymphoproliferative malignancies, but is rarely associated with extranodal systemic ALCL.
  • A 43-year-old man developed lymphomatoid papulosis lesions at 3 years of age, which persisted into adulthood, and he later developed ALCL of the duodenum.
  • Treatment with standard CHOP (cyclophosphamide/doxorubicin/vincristine/prednisolone) chemotherapy resulted in complete remission of his gastrointestinal lymphoma and temporary improvement of his skin lesions.
  • However, the LyP relapsed and proved refractory to psoralen plus ultraviolet-A phototherapy, and was only temporarily and partially responsive to bexarotene and denileukin diftitox.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diphtheria Toxin / therapeutic use. Interleukin-2 / therapeutic use. Intestinal Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphomatoid Papulosis / pathology. Recombinant Fusion Proteins / therapeutic use
  • [MeSH-minor] Adult. Child. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Humans. Male. Prednisone / administration & dosage. Treatment Outcome. Vincristine / administration & dosage


3. Rassidakis GZ, Georgakis GV, Oyarzo M, Younes A, Medeiros LJ: Lack of c-kit (CD117) expression in CD30+ lymphomas and lymphomatoid papulosis. Mod Pathol; 2004 Aug;17(8):946-53
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  • [Title] Lack of c-kit (CD117) expression in CD30+ lymphomas and lymphomatoid papulosis.
  • c-Kit receptor (CD117) is expressed by erythroid, megakaryocytic, and myeloid precursors and mature mast cells and has been reported to be expressed in CD30+ lymphomas such as Hodgkin's disease and anaplastic large-cell lymphoma.
  • Imatinib mesylate, a well-established inhibitor of bcr-abl tyrosine kinase, and currently used for the treatment of patients with chronic myeloid leukemia, also inhibits c-kit receptor kinase activity.
  • In view of the possible use of imatinib as experimental therapy for patients with c-kit-positive tumors, we assessed c-kit expression in CD30+ cell lines and lymphomas.
  • c-Kit expression was also immunohistochemically assessed in 168 CD30+ lymphomas including 87 classical Hodgkin's disease, 63 anaplastic large-cell lymphoma, and 15 cutaneous anaplastic large-cell lymphoma.
  • We also studied 18 cases of lymphomatoid papulosis, a CD30+ lesion closely related to cutaneous anaplastic large-cell lymphoma.
  • Furthermore, treatment with imatinib did not inhibit proliferation of cell lines in vitro.
  • Our data demonstrate that expression of c-kit receptor is exceedingly rare among CD30+ lymphomas and lymphomatoid papulosis, suggesting that c-kit receptor is unlikely to be an appropriate target for therapeutic options such as imatinib in patients with these tumors.
  • [MeSH-major] Lymphoma, Large-Cell, Anaplastic / pathology. Lymphomatoid Papulosis / pathology. Proto-Oncogene Proteins c-kit / biosynthesis
  • [MeSH-minor] Antigens, CD30 / analysis. Antineoplastic Agents / pharmacology. Benzamides. Cell Division / drug effects. Cell Line, Tumor. Flow Cytometry. Hodgkin Disease / genetics. Hodgkin Disease / metabolism. Hodgkin Disease / pathology. Humans. Imatinib Mesylate. Immunohistochemistry. Piperazines / pharmacology. Pyrimidines / pharmacology. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15105813.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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4. Wu S, Bottini M, Rickert RC, Mustelin T, Tautz L: In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation. ChemMedChem; 2009 Mar;4(3):440-4
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  • A gain-of-function mutant of the lymphoid phosphatase Lyp (PTPN22) has recently been implicated in type 1 diabetes and other autoimmune diseases, suggesting that small-molecule inhibitors of Lyp could be useful for the treatment of autoimmunity.
  • Two different docking algorithms, FlexX and ICM, were used to screen a library of 'drug-like' molecules against two different 3D structures, representing the catalytic site of Lyp in both the inactive 'open' and active 'closed' conformations.
  • The top-scoring compounds of each VLS run were tested for their inhibitory activity against recombinant Lyp.

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  • (PMID = 19177473.001).
  • [ISSN] 1860-7187
  • [Journal-full-title] ChemMedChem
  • [ISO-abbreviation] ChemMedChem
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI053585-05; United States / NCI NIH HHS / CA / CA132121; United States / NIAID NIH HHS / AI / R01 AI053585-05; United States / NCI NIH HHS / CA / R21 CA132121; United States / NIAID NIH HHS / AI / AI053585; United States / NIAID NIH HHS / AI / R01 AI053585; United States / NCI NIH HHS / CA / R21 CA132121-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Benzamides; 0 / Ligands; 0 / Recombinant Proteins; 0 / Small Molecule Libraries; 8DUH1N11BX / Tryptophan; EC 3.1.3.48 / PTPN22 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 22
  • [Other-IDs] NLM/ NIHMS287789; NLM/ PMC3102533
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5. Marschalkó M, Eros N, Holló P, Hársing J, Bottlik G, Bátai A, Csukly Z, Masszi T, Szentirmai Z, Fodor J, Kárpáti S, Matolcsy A, Csomor J: Secondary ALK negative anaplastic large cell lymphoma in a patient with lymphomatoid papulosis of 40 years duration. Am J Dermatopathol; 2010 Oct;32(7):708-12
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  • [Title] Secondary ALK negative anaplastic large cell lymphoma in a patient with lymphomatoid papulosis of 40 years duration.
  • He had a history of lymphomatoid papulosis since childhood.
  • At age 44, regional lymph node manifestation of anaplastic lymphoma kinase (ALK) anaplastic large cell lymphoma (ALCL) developed.
  • Chemotherapy resulted in complete remission of the lymphadenopathy.
  • Four years later, systemic relapse was detected which was refractory to therapy.
  • The diagnosis of ALK-negative systemic ALCL with cutaneous symptoms was set up at the second flare up, however, the possibility of primary cutaneous ALCL was not excluded steadily.
  • Lymphomatoid papulosis, primary cutaneous ALCL, and systemic ALK ALCL are 3 different entities but the separation of them cannot be solved without distinctive diagnostic tools.
  • [MeSH-major] Lymphoma, Large-Cell, Anaplastic / pathology. Lymphomatoid Papulosis / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Fatal Outcome. Humans. Male. Middle Aged. Protein-Tyrosine Kinases / metabolism. Receptor Protein-Tyrosine Kinases


6. Newlove T, Loyd A, Patel R, Jelinek J, Latkowski JA: Primary cutaneous anaplastic large-cell lymphoma. Dermatol Online J; 2010;16(11):2
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  • This entity must be distinguished from systemic ALCL with cutaneous involvement and lymphomatoid papulosis.
  • Treatment modalities include clinical monitoring, radiation therapy, and surgical excision, with systemic chemotherapy reserved for disseminated or extracutaneous disease.
  • [MeSH-major] Lymphoma, Primary Cutaneous Anaplastic Large Cell / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Antigens, CD30 / metabolism. Combined Modality Therapy. Humans. Male. Treatment Outcome


7. Kagaya M, Kondo S, Kamada A, Yamada Y, Matsusaka H, Jimbow K: Localized lymphomatoid papulosis. Dermatology; 2002;204(1):72-4
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  • [Title] Localized lymphomatoid papulosis.
  • A 50-year-old Japanese male visited our clinic in April 1999 with a 2-year history of self-healing, reddish papules on his right palm.
  • A biopsy specimen showed a wedge-shaped, dense dermal infiltrate consisting of variously sized mononuclear lymphoid cells mixed with few large CD30-positive cells and inflammatory cells, suggesting the diagnosis of regional lymphomatoid papulosis (LyP).
  • Only 5 cases of LyP presenting in a regional distribution have been reported previously.
  • Although the etiology of localized LyP remains unknown, considering that 2 of 5 reported patients developed widespread lesions regional LyP may be the initial presentation of typical LyP.
  • [MeSH-major] Lymphomatoid Papulosis / drug therapy. Lymphomatoid Papulosis / pathology
  • [MeSH-minor] Administration, Topical. Biopsy, Needle. Drug Therapy, Combination. Follow-Up Studies. Humans. Immunohistochemistry. Injections, Subcutaneous. Interferon-gamma / administration & dosage. Male. Middle Aged. Severity of Illness Index. Steroids / administration & dosage. Treatment Outcome

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  • [Copyright] Copyright 2002 S. Karger AG, Basel
  • (PMID = 11834855.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Steroids; 82115-62-6 / Interferon-gamma
  • [Number-of-references] 11
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8. Bekkenk MW, Geelen FA, van Voorst Vader PC, Heule F, Geerts ML, van Vloten WA, Meijer CJ, Willemze R: Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment. Blood; 2000 Jun 15;95(12):3653-61
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  • [Title] Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment.
  • To evaluate our diagnostic and therapeutic guidelines, clinical and long-term follow-up data of 219 patients with primary or secondary cutaneous CD30(+) lymphoproliferative disorders were evaluated.
  • The study group included 118 patients with lymphomatoid papulosis (LyP; group 1), 79 patients with primary cutaneous CD30(+) large T-cell lymphoma (LTCL; group 2), 11 patients with CD30(+) LTCL and skin and regional lymph node involvement (group 3), and 11 patients with secondary cutaneous CD30(+) LTCL (group 4).
  • Patients with LyP often did not receive any specific treatment, whereas most patients with primary cutaneous CD30(+) LTCL were treated with radiotherapy or excision.
  • All patients with skin-limited disease from groups 1 and 2 who were treated with multiagent chemotherapy had 1 or more skin relapses.
  • The calculated risk for systemic disease within 10 years of diagnosis was 4% for group 1, 16% for group 2, and 20% for group 3 (after initial therapy).
  • Disease-related 5-year-survival rates were 100% (group 1), 96% (group 2), 91% (group 3), and 24% (group 4), respectively.
  • The results confirm the favorable prognoses of these primary cutaneous CD30(+) lymphoproliferative disorders and underscore that LyP and primary cutaneous CD30(+) lymphomas are closely related conditions.
  • Multiagent chemotherapy is only indicated for patients with full-blown or developing extracutaneous disease; it is never or rarely indicated for patients with skin-limited CD30(+) lymphomas. (Blood.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / diagnosis. Lymphoma, T-Cell, Cutaneous / therapy. Lymphoproliferative Disorders / diagnosis. Lymphoproliferative Disorders / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Algorithms. Antigens, CD / analysis. Antigens, CD30 / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / mortality. Neoplasms, Second Primary / therapy. Netherlands. Practice Guidelines as Topic. Skin / immunology. Skin / pathology. Survival Rate. Time Factors

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  • (PMID = 10845893.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD30
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9. Foss HD, Marafioti T, Stein H: [The many faces of anaplastic large cell lymphoma]. Pathologe; 2000 Mar;21(2):124-36
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  • [Transliterated title] Die vielen Gesichter des anaplastischen grosszelligen Lymphoms.
  • ALK-positive ALC-lymphoma predominantly affects young male patients and if treated with chemotherapy has a favourable prognosis.
  • They show a broad morphological spectrum, with the "common type", the small cell variant and the lymphohistiocytic variant being most commonly observed.
  • The knowledge of the existence of these variants is essential in establishing the correct diagnosis.
  • The morphology and the immuno-phenotype of primary cutaneous ALC-lymphoma shows an overlap with that of lymphomatoid papulosis.
  • In contrast, large B-cell-lymphomas with anaplastic morphology are now believed not to represent an own entity but a morphologic variant of diffuse large B-cell lymphoma.

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  • (PMID = 10840818.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] GERMANY
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 32
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10. Dukic R, Derragui A, Geiss S, Wilhelm JM, Thannberger P, Colson A, Kieffer P: [Minocycline-induced lymphomatoid papulosis]. Rev Med Interne; 2004 May;25(5):401-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Minocycline-induced lymphomatoid papulosis].
  • [Transliterated title] Papulose lymphomatoïde atypique à grandes cellules supposée déclenchée par la minocycline.

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  • (PMID = 15110963.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; FYY3R43WGO / Minocycline
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11. Li X, Jin Q, Chen T, Zhang B, Zheng R, Wang Z, Zheng H: LyP-1 ultrasonic microbubbles targeting to cancer cell as tumor bio-acoustics markers or drug carriers: targeting efficiency evaluation in, microfluidic channels. Conf Proc IEEE Eng Med Biol Soc; 2009;2009:463-6
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  • [Title] LyP-1 ultrasonic microbubbles targeting to cancer cell as tumor bio-acoustics markers or drug carriers: targeting efficiency evaluation in, microfluidic channels.
  • Using ultrasonic contrast microbubbles as acoustic biomarkers and drug carrier vehicles by conjugating tumor specific antibody to microbubbles has shown great potential in ultrasonic tumor molecular imaging or drug-delivery and therapy.
  • In this study, we developed a novel method to evaluate the targeting capability and efficiency of microbubbles to cells, and more specifically, microbubbles binding LyP-1 (a cyclic nonapeptide acid peptide) target to cancer cell within a microfluidic system.
  • The system provides a useful low-cost high efficient in vitro platform for studying microbubble-cell interaction for ultrasonic tumor molecular imaging or drug-delivery and therapy.
  • [MeSH-minor] Cell Line, Tumor. Drug Delivery Systems / instrumentation. Drug Delivery Systems / methods. Equipment Design. Equipment Failure Analysis. Female. Humans

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  • (PMID = 19964739.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / LyP-1 peptide; 0 / Peptides, Cyclic
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12. Laube S, Shah F, Marsden J: Consequences of misdiagnosis of lymphomatoid papulosis. Eur J Cancer Care (Engl); 2006 May;15(2):194-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Consequences of misdiagnosis of lymphomatoid papulosis.
  • We report two patients with lymphomatoid papulosis (LyP), who were initially diagnosed as systemic T-cell lymphoma.
  • Consequently, both patients were unnecessarily treated with multi-agent chemotherapy, radiotherapy and stem cell/bone marrow transplants and sustained long-term adverse effects.
  • The clinical and histological features of LyP are described and appropriate management discussed in detail.
  • Factors leading to the unnecessary treatment of both patients are examined and several learning points highlighted such as the importance of a multidisciplinary approach.
  • [MeSH-major] Diagnostic Errors. Lymphoma, T-Cell, Cutaneous / diagnosis. Lymphomatoid Papulosis / diagnosis
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male

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  • (PMID = 16643267.001).
  • [ISSN] 0961-5423
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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13. Seifert G, Tautz C, Seeger K, Henze G, Laengler A: Therapeutic use of mistletoe for CD30+ cutaneous lymphoproliferative disorder/lymphomatoid papulosis. J Eur Acad Dermatol Venereol; 2007 Apr;21(4):558-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic use of mistletoe for CD30+ cutaneous lymphoproliferative disorder/lymphomatoid papulosis.
  • [MeSH-major] Lymphoma, Large-Cell, Anaplastic / drug therapy. Lymphoma, T-Cell, Cutaneous / drug therapy. Lymphomatoid Papulosis / drug therapy. Phytotherapy / methods. Plant Extracts / therapeutic use. Skin Neoplasms / drug therapy. Viscum
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Follow-Up Studies. Humans. Injections, Intralesional. Injections, Subcutaneous. Male. Neoplasm Recurrence, Local / drug therapy

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  • (PMID = 17374000.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Plant Extracts; 0 / viscum fraxini-2
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14. Kadin ME: Current management of primary cutaneous CD30+ T-cell lymphoproliferative disorders. Oncology (Williston Park); 2009 Nov 30;23(13):1158-64
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  • Primary cutaneous CD30+ T-cell lymphoproliferative disorders (PCLPDs) are the second most common type of cutaneous T-cell lymphoma.
  • These disorders comprise a spectrum of clinically benign lymphomatoidpapulosis (LyP) and primary cutaneous anaplastic large-cell lymphoma (ALCL).
  • The peak incidence of LyP is in the 5th decade of life, and the incidence of primary cutaneous ALCL peaks in the 6th decade, but children are also affected.
  • Both LyP and primary cutaneous ALCL have an excellent prognosis.
  • However, LyP is associated with development of malignant lymphoma (mycosis fungoides, Hodgkin lymphoma, or ALCL) in 20% of cases, and also with an increased risk of non-lymphoid cancers.
  • The diagnosis of LyP is difficult and often delayed.
  • Correlation of clinical findings with histopathology and immunopathology (stains for ALK kinase, epithelial membrane antigen, and cutaneous lymphocyte antigen) are important to achieve a correct diagnosis.
  • When a diagnosis of CD30+ PCLPD is established, minimal clinical staging is required.
  • Low-dose methotrexate (10-25 mg weekly) is the most effective therapy for PCLPD but is usually reserved for aggressive cases of LyP and multifocal lesions of cutaneous ALCL Many patients with LyP can be followed expectantly, with special attention to changes in character of the skin lesions or development of lymphadenopathy.
  • Extracutaneous spread of disease is an indication for multiagent chemotherapy.
  • Other treatment alternatives are discussed.
  • [MeSH-major] Antimetabolites, Antineoplastic / administration & dosage. Lymphoma, Primary Cutaneous Anaplastic Large Cell / drug therapy. Methotrexate / administration & dosage. Skin Neoplasms / drug therapy
  • [MeSH-minor] Antigens, CD30 / metabolism. Diagnosis, Differential. Humans

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  • (PMID = 20043465.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20RR018757
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Antimetabolites, Antineoplastic; YL5FZ2Y5U1 / Methotrexate
  • [Number-of-references] 32
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15. Flendrie M, Vissers WH, Creemers MC, de Jong EM, van de Kerkhof PC, van Riel PL: Dermatological conditions during TNF-alpha-blocking therapy in patients with rheumatoid arthritis: a prospective study. Arthritis Res Ther; 2005;7(3):R666-76
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  • [Title] Dermatological conditions during TNF-alpha-blocking therapy in patients with rheumatoid arthritis: a prospective study.
  • Various dermatological conditions have been reported during tumor necrosis factor (TNF)-alpha-blocking therapy, but until now no prospective studies have been focused on this aspect.
  • The present study was set up to investigate the number and nature of clinically important dermatological conditions during TNF-alpha-blocking therapy in patients with rheumatoid arthritis (RA).
  • RA patients starting on TNF-alpha-blocking therapy were prospectively followed up.
  • The patients with a dermatological event were compared with a group of prospectively followed up RA control patients, naive to TNF-alpha-blocking therapy and matched for follow-up period.
  • 289 RA patients started TNF-alpha-blocking therapy.
  • TNF-alpha-blocking therapy was stopped in 19 (26%) of these 72 patients because of the dermatological event.
  • More of the RA patients given TNF-alpha-blocking therapy (25%) than of the anti-TNF-alpha-naive patients (13%) visited a dermatologist during follow-up (P < 0.0005).
  • Events were recorded more often during active treatment (0.16 events per patient-year) than during the period of withdrawal of TNF-alpha-blocking therapy (0.09 events per patient-year, P < 0.0005).
  • The events recorded most frequently were skin infections (n = 33), eczema (n = 20), and drug-related eruptions (n = 15).
  • Other events with a possible relation to TNF-alpha-blocking therapy included vasculitis, psoriasis, drug-induced systemic lupus erythematosus, dermatomyositis, and a lymphomatoid-papulosis-like eruption.
  • This study is the first large prospective study focusing on dermatological conditions during TNF-alpha-blocking therapy.
  • It shows that dermatological conditions are a significant and clinically important problem in RA patients receiving TNF-alpha-blocking therapy.
  • [MeSH-major] Antirheumatic Agents / adverse effects. Arthritis, Rheumatoid / drug therapy. Skin Diseases / chemically induced. Tumor Necrosis Factor-alpha / antagonists & inhibitors

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  • (PMID = 15899052.001).
  • [ISSN] 1478-6362
  • [Journal-full-title] Arthritis research & therapy
  • [ISO-abbreviation] Arthritis Res. Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antirheumatic Agents; 0 / Tumor Necrosis Factor-alpha
  • [Other-IDs] NLM/ PMC1174960
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16. Drews R, Samel A, Kadin ME: Lymphomatoid papulosis and anaplastic large cell lymphomas of the skin. Semin Cutan Med Surg; 2000 Jun;19(2):109-17
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  • [Title] Lymphomatoid papulosis and anaplastic large cell lymphomas of the skin.
  • It is now generally accepted that primary CD30+ cutaneous lymphomas comprise a clinical and morphologic spectrum in which a clear distinction between lymphomatoid papulosis (LyP) and lymphoma cannot always be made.
  • Management varies from observation in patients who have relatively asymptomatic, spontaneously remitting disease (as in LyP) to multiagent chemotherapy regimens with or without autologous stem cell transplantation in patients whose disease has spread to involve extracutaneous sites other than regional lymph nodes (as in disseminated CD30+ lymphoma).
  • The importance of clinicopathologic correlation cannot be overemphasized, because lesions with clinically "benign" behavior may appear "malignant" by pathology, and failure to interpret pathologic findings in accordance with the patient's clinical history and physical exam can result in unnecessary, overly aggressive, and potentially harmful treatments.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphomatoid Papulosis / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Antigens, CD30 / blood. Diagnosis, Differential. Genotype. Humans. Immunophenotyping. Lymphoma, Large-Cell, Anaplastic / diagnosis. Mycosis Fungoides / diagnosis. Phenotype. Pityriasis Lichenoides / diagnosis. Recurrence. Remission Induction. Survival Analysis. T-Lymphocytes, Helper-Inducer / pathology

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  • (PMID = 10892712.001).
  • [ISSN] 1085-5629
  • [Journal-full-title] Seminars in cutaneous medicine and surgery
  • [ISO-abbreviation] Semin Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antigens, CD30
  • [Number-of-references] 43
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17. Rifkin S, Valderrama E, Lipton JM, Karayalcin G: Lymphomatoid papulosis and Ki-1+ anaplastic large cell lymphoma occurring concurrently in a pediatric patient. J Pediatr Hematol Oncol; 2001 Jun-Jul;23(5):321-3
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  • [Title] Lymphomatoid papulosis and Ki-1+ anaplastic large cell lymphoma occurring concurrently in a pediatric patient.
  • Lymphomatoid papulosis (LyP) is a benign, self-healing, papular eruption that can wax and wane over the course of time.
  • Transformation to T-cell lymphoma has been well documented in 10% to 20% of adults with LyP, but there are have been no cases reported in patients younger than age 26 years.
  • We describe the first pediatric patient, a 16-year-old girl, who had clinical features of LyP and concurrently was found to have a lesion diagnosed as Ki-1+ anaplastic large cell lymphoma.
  • After treatment with chemotherapy, she has been in continuous remission for 16 months.
  • [MeSH-major] Lymphoma, Large-Cell, Anaplastic / complications. Lymphomatoid Papulosis / complications
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor. Clone Cells / chemistry. Clone Cells / pathology. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Neoplasm Invasiveness. Neoplastic Stem Cells / chemistry. Neoplastic Stem Cells / pathology. Prednisone / administration & dosage. Remission Induction. Shoulder. Vincristine / administration & dosage

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  • (PMID = 11464993.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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18. Ingen-Housz-Oro S, Bagot M: [Cutaneous lymphomas]. Rev Prat; 2009 Nov 20;59(9):1207-15
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  • Cutaneous lymphomas are lymphoproliferations affecting skin only at the time of diagnosis.
  • There are two major types, B-cell lymphomas and T-cell lymphomas, which prognosis depends of histological subtype and staging evaluation.
  • In cutaneous B-cell lymphomas, there are two indolent subtypes (primary cutaneous marginal zone B-cell lymphoma and primary cutaneous follicle center lymphoma) and one more aggressive type (primary cutaneous diffuse large B-cell lymphoma, leg type).
  • Classification of T-cell lymphomas distinguishes indolent subtypes such as mycosis fungoides, the most frequent of T-cell lymphomas, and CD30+ lymphoproliferations such as lymphomatoid papulosis, whereas other T-cell lymphoma subtypes have a more pejorative prognosis such as Sezary syndrome (erythrodermic and leukemic form of mycosis fungoides) and CD30- lymphomas.
  • Staging evaluation with CT-scan of chest, abdomen and pelvis, bone marrow examination if necessary and lymph node biopsy if palpable node over 1 or 1.5 cm diameter, is necessary for therapeutic decision.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Immunohistochemistry. Lymphoma, B-Cell / diagnosis. Lymphoma, B-Cell / drug therapy. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / radiography. Lymphoma, B-Cell / radiotherapy. Lymphoma, B-Cell / surgery. Lymphoma, T-Cell / diagnosis. Lymphoma, T-Cell / drug therapy. Lymphoma, T-Cell / pathology. Lymphoma, T-Cell / radiography. Lymphoma, T-Cell / radiotherapy. Lymphoma, T-Cell / surgery. Mycosis Fungoides / diagnosis. Mycosis Fungoides / radiography. Neoplasm Staging. Prognosis. Radiography, Abdominal. Radiography, Thoracic. Sezary Syndrome / diagnosis. Sezary Syndrome / pathology. Sezary Syndrome / radiography. Skin / pathology. Tomography, X-Ray Computed

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  • (PMID = 19961071.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 16
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19. Stein H, Foss HD, Dürkop H, Marafioti T, Delsol G, Pulford K, Pileri S, Falini B: CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood; 2000 Dec 1;96(12):3681-95
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  • ALK(+) ALCL predominantly affects young male patients and, if treated with chemotherapy, has a favorable prognosis.
  • It shows a broad morphologic spectrum, with the "common type," the small cell variant, and the lymphohistiocytic variant being most commonly observed.
  • The knowledge of the existence of these variants is essential in establishing a correct diagnosis.
  • The morphology and the immunophenotype of primary cutaneous ALCL show an overlap with that of lymphomatoid papulosis.
  • In contrast, large B-cell lymphomas with anaplastic morphology are believed to represent not a separate entity but a morphologic variant of diffuse large B-cell lymphoma.
  • Malignant lymphomas with morphologic features of both Hodgkin disease and ALCL have formerly been classified as Hodgkin-like ALCL.
  • Recent immunohistologic studies, however, suggest that ALCLs Hodgkin-like represent either cases of tumor cell-rich classic Hodgkin disease or (less commonly) ALK(+) ALCL or ALK(-) ALCL. (Blood.
  • [MeSH-minor] Gene Rearrangement. Hodgkin Disease. Humans. Immunophenotyping. Nuclear Proteins / genetics. Protein-Tyrosine Kinases / genetics. Receptor Protein-Tyrosine Kinases. Translocation, Genetic

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  • (PMID = 11090048.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Nuclear Proteins; 117896-08-9 / nucleophosmin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
  • [Number-of-references] 157
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20. Su LD, Duncan LM: Lymphoma- and leukemia-associated cutaneous atypical CD30+ T-cell reactions. J Cutan Pathol; 2000 May;27(5):249-54
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  • Cutaneous CD30+ lymphoid infiltrates appear cytologically atypical and occasionally may be misinterpreted as recurrent disease when they occur in patients treated for other primary hematologic malignancies.
  • One patient with B-cell lymphoma and another with myeloid leukemia developed cutaneous eruptions after chemotherapy displaying highly atypical perivascular lymphoid cells on histology that mimicked recurrent disease.
  • We discuss the differential diagnosis of atypical CD30+ infiltrates in this setting, which include recurrent lymphoma or myeloid leukemia, primary cutaneous anaplastic large cell lymphoma (ALCL), lymphomatoid papulosis (LyP), carbamazepine-induced CD30+ pseudolymphoma, viral infection and an atypical eruption of lymphocyte recovery.
  • [MeSH-minor] Carbamazepine / adverse effects. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Lymphoma, Large-Cell, Anaplastic / diagnosis. Lymphomatoid Papulosis / diagnosis. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Pseudolymphoma / chemically induced. Pseudolymphoma / diagnosis. Skin Diseases, Viral / diagnosis

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  • (PMID = 10847550.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] DENMARK
  • [Chemical-registry-number] 0 / Antigens, CD30; 33CM23913M / Carbamazepine
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21. Herron MD, Bohnsack JF, Vanderhooft SL: Septic, CD-30 positive febrile ulceronecrotic pityriasis lichenoides et varioliformis acuta. Pediatr Dermatol; 2005 Jul-Aug;22(4):360-5
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  • Sepsis delayed definitive treatment of the underlying cutaneous disease for 2 weeks.
  • Combined therapy with methotrexate and cyclosporin caused remission of the process.
  • Although immunohistochemistry revealed CD-30 positive cells, suggesting the diagnosis of lymphomatoid papulosis, the histopathology was most compatible with pityriasis lichenoides et varioliformis acuta.
  • Elevated soluble interleukin-2 receptor levels reflected marked T-cell activation, and the downward trend of the levels during treatment coincided with clinical regression of this inflammatory dermatosis.
  • [MeSH-major] Antigens, CD30 / analysis. Fever / etiology. Pityriasis Lichenoides / diagnosis. Sepsis / microbiology. Skin Ulcer / etiology
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Bacteremia / drug therapy. Bacteremia / microbiology. Candida / isolation & purification. Child. Drug Therapy, Combination. Female. Fungemia / drug therapy. Fungemia / microbiology. Humans. Immunosuppressive Agents / therapeutic use. Lymphocytes / immunology. Lymphocytes / metabolism. Pseudomonas aeruginosa / isolation & purification. Receptors, Interleukin-2 / blood. Respiratory Distress Syndrome, Adult / therapy. Staphylococcus epidermidis / isolation & purification


22. Granel B, Serratrice J, Swiader L, Horshowski N, Blaise D, Vey N, Metras D, Habib G, Disdier P, Weiller PJ: Lymphomatoid papulosis associated with both severe hypereosinophilic syndrome and CD30 positive large T-cell lymphoma. Cancer; 2000 Nov 15;89(10):2138-43
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  • [Title] Lymphomatoid papulosis associated with both severe hypereosinophilic syndrome and CD30 positive large T-cell lymphoma.
  • BACKGROUND: Previous reports have found an association between lymphomatoid papulosis and hypereosinophilic syndrome, as well as lymphomatoid papulosis and lymphoma.
  • METHODS: The authors followed the clinical course of a 64-year-old man with lymphomatoid papulosis associated with severe hypereosinophilic syndrome complicated by involvement of the lungs and heart.
  • The bone marrow biopsy was typical of hypereosinophilic syndrome associated with fibrosis, with focal lymphomatous infiltrates comprised of large cells resembling the type A cells of lymphomatoid papulosis.
  • Complete remission of the lymphoma was obtained with chemotherapy.
  • Lymphomatoid papulosis belongs to the spectrum of CD30 positive lymphoproliferative disorders and CD30 positive lymphocytes of lymphomatoid papulosis are known to have a Th2 profile with possible secretion of eosinopoietic cytokines.
  • [MeSH-major] Antigens, CD30 / analysis. Hypereosinophilic Syndrome / complications. Lymphoma, T-Cell / complications. Lymphomatoid Papulosis / complications

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  • [Copyright] Copyright 2000 American Cancer Society.
  • (PMID = 11066056.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antigens, CD30
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23. Willemze R, Meijer CJ: Primary cutaneous CD30-positive lymphoproliferative disorders. Hematol Oncol Clin North Am; 2003 Dec;17(6):1319-32, vii-viii
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  • Primary cutaneous CD30-positive (anaplastic) large T-cell lymphoma and lymphomatoid papulosis have many overlapping clinical, histologic, and immunophenotypic features.
  • We provide the clinician with practical guidelines for the diagnosis, management, and treatment of patients within this spectrum of primary cutaneous CD30-positive lymphoproliferative disorders.
  • Most patients within this spectrum of disease have an excellent prognosis.
  • Multi-agent chemotherapy should be reserved for patients who have extracutaneous disease.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Transformation, Neoplastic. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Lymphomatoid Papulosis / etiology. Lymphomatoid Papulosis / pathology. Male. Middle Aged. Remission, Spontaneous. Virus Diseases / complications

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  • (PMID = 14710887.001).
  • [ISSN] 0889-8588
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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24. Barr AJ: Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development. Future Med Chem; 2010 Oct;2(10):1563-76
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  • [Title] Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.
  • Several 'classical' protein tyrosine phosphatases are attractive therapeutic targets, including PTP1B for obesity and Type II diabetes; SHP2 for cancer and Lyp for rheumatoid arthritis.
  • [MeSH-major] Drug Discovery / methods. Enzyme Inhibitors / chemistry. Enzyme Inhibitors / pharmacology. Protein Tyrosine Phosphatases / antagonists & inhibitors. Protein Tyrosine Phosphatases / metabolism
  • [MeSH-minor] Animals. Autoimmune Diseases / drug therapy. Autoimmune Diseases / enzymology. Diabetes Mellitus, Type 2 / drug therapy. Diabetes Mellitus, Type 2 / enzymology. Humans. Models, Molecular. Neoplasms / drug therapy. Neoplasms / enzymology. Obesity / drug therapy. Obesity / enzymology

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  • (PMID = 21426149.001).
  • [ISSN] 1756-8927
  • [Journal-full-title] Future medicinal chemistry
  • [ISO-abbreviation] Future Med Chem
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / ; Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 3.1.3.48 / Protein Tyrosine Phosphatases
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25. Ghiggeri GM, Bleid D, Garaventa A, Coccia C, Gambini C, Caridi G, Perfumo F: Recurrent lymphomatoid papulosis associated with nephrotic syndrome. An occurrence of uncertain origin. Pediatr Nephrol; 2009 Jan;24(1):189-92
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  • [Title] Recurrent lymphomatoid papulosis associated with nephrotic syndrome. An occurrence of uncertain origin.
  • We report on a 10-year-old child with nephrotic syndrome who developed recurrent lymphomatoid papulosis (LYP) 60 months after the first episode of proteinuria.
  • LYP appeared when the child was taking low-dose cyclosporin and disappeared after the drug was replaced by prednisone at doses utilized for nephrotic syndrome (2 mg/kg).
  • During the tapering of steroids, when the child was treated with low-dose prednisone (0.2 mg/kg), both LYP and nephrotic syndrome started again and required the reintroduction of prednisone to restore a normal clinical situation.
  • This is the first case of LYP occurring in concomitance and synchronous with nephrotic syndrome.
  • LYP was unrelated to cyclosporin (second episode after its withdrawn) but preceded the recurrence of proteinuria, suggesting a relationship with the disease activity.
  • Even though the etiology of LYP is, in this case, uncertain, it should be considered as a clinical association of nephrotic syndrome in children and also included among potential triggers of the disease.
  • [MeSH-major] Lymphomatoid Papulosis / pathology. Nephrotic Syndrome / pathology
  • [MeSH-minor] Child. Cyclosporine / therapeutic use. Dose-Response Relationship, Drug. Glucocorticoids / therapeutic use. Humans. Immunosuppressive Agents / therapeutic use. Male. Prednisone / therapeutic use. Proteinuria / drug therapy. Proteinuria / etiology. Proteinuria / pathology. Recurrence

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  • (PMID = 18026996.001).
  • [ISSN] 0931-041X
  • [Journal-full-title] Pediatric nephrology (Berlin, Germany)
  • [ISO-abbreviation] Pediatr. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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26. Mäkelä AR, Matilainen H, White DJ, Ruoslahti E, Oker-Blom C: Enhanced baculovirus-mediated transduction of human cancer cells by tumor-homing peptides. J Virol; 2006 Jul;80(13):6603-11
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  • Tumor cells and vasculature offer specific targets for the selective delivery of therapeutic genes.
  • LyP-1, F3, and CGKRK tumor-homing peptides, originally identified by in vivo screening of phage display libraries, were fused to the transmembrane anchor of vesicular stomatitis virus G protein and displayed on the baculoviral surface.
  • The LyP-1 peptide inhibited viral binding to MDA-MB-435 cells with a greater magnitude and specificity than the CGKRK and F3 peptides.
  • The internalization of each virus was inhibited by ammonium chloride treatment, suggesting the use of a similar endocytic entry route.
  • The LyP-1 and F3 peptides showed an apparent inhibitory effect in transduction of HepG2 cells with the corresponding display viruses.
  • Together, these results imply that the efficiency of baculovirus-mediated gene delivery can be significantly enhanced in vitro when tumor-targeting ligands are used and therefore highlight the potential of baculovirus vectors in cancer gene therapy.
  • [MeSH-minor] Breast Neoplasms / genetics. Breast Neoplasms / therapy. Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / therapy. Cell Line, Tumor. Genetic Therapy. Humans. Peptide Library. Protein Binding / drug effects. Protein Binding / genetics. Vesicular stomatitis Indiana virus / genetics

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  • (PMID = 16775347.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Capsid Proteins; 0 / Glycoproteins; 0 / Neoplasm Proteins; 0 / Peptide Library; 0 / Peptides
  • [Other-IDs] NLM/ PMC1488948
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27. Koury MJ, Newman JH, Murray JJ: Reversal of hypereosinophilic syndrome and lymphomatoid papulosis with mepolizumab and imatinib. Am J Med; 2003 Nov;115(7):587-9
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  • [Title] Reversal of hypereosinophilic syndrome and lymphomatoid papulosis with mepolizumab and imatinib.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Hypereosinophilic Syndrome / drug therapy. Lymphomatoid Papulosis / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Antibodies, Monoclonal, Humanized. Benzamides. Drug Therapy, Combination. Female. Humans. Imatinib Mesylate. Interleukin-5 / blood. Middle Aged. Protein-Tyrosine Kinases / antagonists & inhibitors

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  • (PMID = 14599646.001).
  • [ISSN] 0002-9343
  • [Journal-full-title] The American journal of medicine
  • [ISO-abbreviation] Am. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Benzamides; 0 / Interleukin-5; 0 / Piperazines; 0 / Pyrimidines; 0 / mepolizumab; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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28. Luo G, Yu X, Jin C, Yang F, Fu D, Long J, Xu J, Zhan C, Lu W: LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors. Int J Pharm; 2010 Jan 29;385(1-2):150-6
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  • [Title] LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors.
  • Active tumor targeting by biodegradable nanoparticles has been widely studied for cancer diagnosis and therapy.
  • However, target-specific nanoparticles for drug delivery to lymphatic metastases have not been reported yet due to the lack of specific markers in the tumor lymphatics.
  • Recently, peptide LyP-1 has been recognized for its specific home to tumors and their lymphatics.
  • In this study, we tested the possibility of LyP-1 serving as a target-specific peptide of PEG-PLGA nanoparticles to tumor lymph metastases.
  • LyP-1 was synthesized by using Boc-protected amino acids.
  • LyP-1 with sulfhydryl group was conjugated to the maleimide function located at the distal end of PEG surrounding the nanoparticle surface.
  • LyP-1-conjugated PEG-PLGA nanoparticle (LyP-1-NPs) had a round and regular shape with a diameter around 90 nm.
  • In vitro, cellular uptake of LyP-1-NPs was about four times of that of PEG-PLGA nanoparticles without LyP-1 (NPs).
  • In vivo, the uptake of LyP-1-NPs in metastasis lymph nodes was about eight times of that of NPs.
  • This study indicates that LyP-1-NP is a promising carrier for target-specific drug delivery to lymphatic metastatic tumors.
  • [MeSH-major] Antineoplastic Agents / metabolism. Drug Carriers. Lymph Nodes / metabolism. Maleimides / chemistry. Nanoparticles. Pancreatic Neoplasms / metabolism. Peptides, Cyclic / metabolism. Polyethylene Glycols / chemistry. Polyglactin 910 / chemistry

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  • [Copyright] 2009 Elsevier B.V. All rights reserved.
  • (PMID = 19825404.001).
  • [ISSN] 1873-3476
  • [Journal-full-title] International journal of pharmaceutics
  • [ISO-abbreviation] Int J Pharm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Carriers; 0 / LyP-1 peptide; 0 / Maleimides; 0 / Peptides, Cyclic; 0 / poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer; 30IQX730WE / Polyethylene Glycols; 34346-01-5 / Polyglactin 910
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29. Vang T, Miletic AV, Arimura Y, Tautz L, Rickert RC, Mustelin T: Protein tyrosine phosphatases in autoimmunity. Annu Rev Immunol; 2008;26:29-55
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  • Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency.
  • Finally, we discuss the possibility that PTPs regulating the immune system may serve as therapeutic targets.
  • [MeSH-major] Autoimmunity / physiology. Protein Tyrosine Phosphatase, Non-Receptor Type 22 / metabolism. Protein Tyrosine Phosphatases / metabolism
  • [MeSH-minor] Animals. Antigens, CD45 / genetics. Antigens, CD45 / metabolism. Autoimmune Diseases / drug therapy. Autoimmune Diseases / genetics. Autoimmune Diseases / metabolism. Humans. Polymorphism, Single Nucleotide. Protein Kinase Inhibitors / therapeutic use

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  • (PMID = 18303998.001).
  • [ISSN] 0732-0582
  • [Journal-full-title] Annual review of immunology
  • [ISO-abbreviation] Annu. Rev. Immunol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI53585
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPN22 protein, human; EC 3.1.3.48 / PTPRC protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 22; EC 3.1.3.48 / Protein Tyrosine Phosphatases
  • [Number-of-references] 152
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30. Duvic M, Reddy SA, Pinter-Brown L, Korman NJ, Zic J, Kennedy DA, Lorenz J, Sievers EL, Kim YH: A phase II study of SGN-30 in cutaneous anaplastic large cell lymphoma and related lymphoproliferative disorders. Clin Cancer Res; 2009 Oct 1;15(19):6217-24
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  • PURPOSE: An open-label, multicenter, phase II study was conducted to define the safety and antitumor activity of the monoclonal antibody SGN-30 in patients with CD30(+) primary cutaneous anaplastic large cell lymphoma (pc-ALCL), lymphomatoid papulosis (LyP), or transformed mycosis fungoides (T-MF).
  • Overall, clinical benefit of SGN-30, as assessed by achieving a response to therapy or stable disease (CR + PR + stable disease), was shown by 87% of patients during the study, including all patients with pc-ALCL or LyP and two thirds of patients with T-MF or with multiple clinical diagnoses.
  • CONCLUSIONS: SGN-30 was clinically active in 16 of 23 patients with heavily pretreated pc-ALCL, LyP, and T-MF and was well tolerated in this study.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Lymphoma, Large-Cell, Anaplastic / therapy. Lymphoproliferative Disorders / therapy. Skin Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Algorithms. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Dose-Response Relationship, Drug. Female. Humans. Immunotherapy / methods. Male. Middle Aged. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 19789316.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00099255
  • [Grant] United States / PHS HHS / / K24
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / SGN-30 monoclonal antibody
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31. Au WY, Yeung CK, Chan HH, Wong RW, Shek TW: CD30-positive cutaneous T-cell lymphoma with concurrent solid tumour. Br J Dermatol; 2002 Jun;146(6):1091-5
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  • The prognosis of CD30+ cutaneous T-cell lymphoma (CTCL) is good in the absence of nodal primary or disseminated disease.
  • These lesions can undergo spontaneous regression, and overlap with the group of lesions of lymphomatoid papulosis.
  • The CTCL responded completely to chemotherapy in one patient, who eventually succumbed to gastric cancer.


32. Tenikoff D, Murphy KJ, Le M, Howe PR, Howarth GS: Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventative treatment modality for inflammatory bowel disease. J Gastroenterol; 2005 Apr;40(4):361-5
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  • [Title] Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventative treatment modality for inflammatory bowel disease.
  • We investigated the effect of pretreatment with Lyprinol (LYP) on experimentally induced inflammatory bowel disease (IBD) in mice.
  • METHODS: Male C57BL/6 mice (aged 6 weeks) were gavaged daily for 13 days with (150 microl) olive oil (OO; n = 7), fish oil (FO; n = 8), or LYP (n = 8).
  • Body weight and disease activity index (DAI) scores were recorded daily.
  • RESULTS: LYP treatment significantly (P < 0.05) reduced body weight loss, DAI scores, crypt area losses, and cecum and colon weights, compared with FO treatment.
  • MPO activity was not significantly affected by any treatment.
  • [MeSH-major] Colitis, Ulcerative / prevention & control. Lipids / therapeutic use
  • [MeSH-minor] Administration, Oral. Animals. Body Weight / drug effects. Colon / drug effects. Colon / enzymology. Colon / pathology. Dextran Sulfate / toxicity. Disease Models, Animal. Disease Progression. Drug Therapy, Combination. Fish Oils / administration & dosage. Fish Oils / therapeutic use. Follow-Up Studies. Male. Mice. Mice, Inbred C57BL. Olive Oil. Organ Size / drug effects. Peroxidase / metabolism. Plant Oils / administration & dosage. Plant Oils / therapeutic use. Plasma Substitutes / toxicity. Treatment Outcome

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  • (PMID = 15870972.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Fish Oils; 0 / Lipids; 0 / Olive Oil; 0 / Plant Oils; 0 / Plasma Substitutes; 0 / lyprinol; 9042-14-2 / Dextran Sulfate; EC 1.11.1.7 / Peroxidase
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