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1. Makol A, Kosuri K, Tamkus D, de M Calaca W, Chang HT: Lymphomatoid granulomatosis masquerading as interstitial pneumonia in a 66-year-old man: a case report and review of literature. J Hematol Oncol; 2009;2:39
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphomatoid granulomatosis masquerading as interstitial pneumonia in a 66-year-old man: a case report and review of literature.
  • Lymphomatoid granulomatosis (LG) is a rare, Epstein-Barr virus (EBV)-associated systemic angiodestructive lymphoproliferative disorder that may progress to a diffuse large B cell lymphoma.
  • Pulmonary involvement may mimic other more common lung pathologies including pneumonias.
  • Therapeutic standards have not been established for LG, but rituximab, interferon-alpha2b (INF-alpha2b), and chemotherapy have shown to improve symptoms and long term prognosis.We report a case of rapid respiratory deterioration in a 66-year-old man with clinical presentation, chest radiography, pulmonary function testing and high resolution computed tomography (HRCT) findings consistent with idiopathic interstitial pneumonia, but very poor response to antibiotics and low dose steroids.
  • Lung biopsy showed histopathology consistent with LG that was confirmed by a positive in situ hybridization for Epstein - Barr virus encoded RNA (EBER).
  • The patient was treated with rituximab and combination chemotherapy and showed significant initial clinical improvement with gradual resolution of abnormal findings on imaging.
  • However, the patient developed pancytopenia as a complication of chemotherapy and died secondary to septic shock and renal failure that were refractory to medical management.
  • Autopsy showed diffuse alveolar damage but no evidence of any residual LG within the lungs.This case demonstrates that an open lung biopsy or video-assisted thoracoscopic surgical (VATS) biopsy is often necessary to rule out the presence of LG in order to determine the appropriate therapeutic strategy early in the course of illness to improve prognosis.
  • [MeSH-major] Lung Diseases, Interstitial / diagnosis. Lung Neoplasms / diagnosis. Lymphomatoid Granulomatosis / diagnosis


2. Miyashita T, Yoshioka K, Nakamura T, Kubo Y, Inoue T, Morikawa T, Ishii K, Yamagami K: A case of lymphomatoid granulomatosis-like lung lesions with abundant infiltrating IgG4-positive plasma cells whose serum IgG4 levels became high following the start of corticosteroid therapy. Intern Med; 2010;49(18):2007-11
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  • [Title] A case of lymphomatoid granulomatosis-like lung lesions with abundant infiltrating IgG4-positive plasma cells whose serum IgG4 levels became high following the start of corticosteroid therapy.
  • A 59-year-old man with a history of prostate hyperplasia was admitted to our hospital for further examination of a lung mass and renal dysfunction.
  • Lung biopsy specimens revealed that inflammatory cells had infiltrated into the blood vessel walls.
  • We initially suspected lymphomatoid granulomatosis, but Epstein Barr virus-encoded small RNA was negative.
  • Prednisolone reduced the lung masses and ameliorated renal function, but the serum IgG4 level increased (377 mg/dL).
  • Seronegative IgG4-related sclerosing disease should be considered when patients present with such symptoms and treatment responses, and the secretion of IgG4 might be blocked by its active synthesis.
  • [MeSH-major] Immunoglobulin G / blood. Lung Neoplasms / chemically induced. Lymphomatoid Granulomatosis / chemically induced. Plasma Cells / pathology. Prednisolone / adverse effects
  • [MeSH-minor] Chemotaxis, Leukocyte / drug effects. Humans. Male. Middle Aged

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  • (PMID = 20847508.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Immunoglobulin G; 9PHQ9Y1OLM / Prednisolone
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3. Bräunlich J, Seyfarth HJ, Gessner C, Gradistanac T, Wirtz H: [Lymphomatoid granulomatosis--a short description of an unusual case of the disease]. Pneumologie; 2009 Dec;63(12):697-701
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  • [Title] [Lymphomatoid granulomatosis--a short description of an unusual case of the disease].
  • Lymphomatoid granulomatosis (LYG) is a rare disease with an unknown pathogenesis.
  • It is considered as a B-cell disorder with an uncertain malignant potential.
  • The disease is classified as an angiocentric and angiodestructive lymphoproliferative disorder.
  • EBV-association (LMP1) and the detection of the surface antigens CD20 and CD30 are the characteristic pathological findings.
  • The lung, the nervous system, the kidneys and the liver are affected most frequently.
  • In addition to CT and bronchoscopy, a surgical biopsy was performed to confirm the diagnosis of lymphomatoid granulomatosis.
  • Treatment consisted in chemotherapy with rituximab, cyclophosphamide, vincristine and prednisolone (R-CVP).
  • [MeSH-major] Lung Diseases / diagnosis. Lung Diseases / therapy. Lymphomatoid Granulomatosis / diagnosis. Lymphomatoid Granulomatosis / therapy
  • [MeSH-minor] Aged. Humans. Male. Rare Diseases / diagnosis. Rare Diseases / therapy

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  • [Copyright] Georg Thieme Verlag KG Stuttgart-New York.
  • (PMID = 19890779.001).
  • [ISSN] 1438-8790
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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4. Oren H, Irken G, Kargi A, Ozkal S, Uçar C, Gülen H, Duman M, Atabay B, Yilmaz S, Kovanlikaya A: A pediatric case of lymphomatoid granulomatosis with onset after completion of chemotherapy for acute myeloid leukemia. J Pediatr Hematol Oncol; 2003 Feb;25(2):163-6
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  • [Title] A pediatric case of lymphomatoid granulomatosis with onset after completion of chemotherapy for acute myeloid leukemia.
  • In this case report, we present a pediatric case of lymphomatoid granulomatosis (LG) with onset just after the completion of chemotherapy for childhood acute myeloid leukemia (AML).
  • After the completion of maintenance therapy, the patient was admitted to our clinic with a complaint of cough.
  • The histopathologic examination of the open lung biopsy was consistent with LG.
  • He received only one cycle of cyclophosphamide and high-dose methyl prednisolone treatment and continued to receive interferon (IFN) alpha-2b therapy for 18 months.
  • This treatment regimen resulted in an excellent response.
  • In conclusion, LG may occur after the treatment of pediatric AML as a rare complication and IFN alpha-2b may be an effective treatment choice in these patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Kidney Neoplasms / diagnosis. Leukemia, Myeloid / drug therapy. Liver Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Lymphomatoid Granulomatosis / diagnosis
  • [MeSH-minor] Acute Disease. Child. Cyclophosphamide / administration & dosage. Humans. Interferon-alpha / administration & dosage. Male. Methylprednisolone / administration & dosage. Recombinant Proteins. Treatment Outcome


5. Shanti RM, Torres-Cabala CA, Jaffe ES, Wilson WH, Brahim JS: Lymphomatoid granulomatosis with involvement of the hard palate: a case report. J Oral Maxillofac Surg; 2008 Oct;66(10):2161-3
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  • [Title] Lymphomatoid granulomatosis with involvement of the hard palate: a case report.
  • [MeSH-major] B-Lymphocytes / virology. Lung Neoplasms / pathology. Lymphomatoid Granulomatosis / drug therapy. Palatal Neoplasms / secondary. Palate, Hard / pathology
  • [MeSH-minor] Adult. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Antiviral Agents / therapeutic use. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Fatal Outcome. Female. Herpesvirus 4, Human / isolation & purification. Humans. Interferon-alpha / therapeutic use. Prednisone / administration & dosage. Rituximab. Vincristine / administration & dosage

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  • [Cites] Clin Imaging. 2004 May-Jun;28(3):209-13 [15158227.001]
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  • (PMID = 18848119.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 DE999999
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antiviral Agents; 0 / Interferon-alpha; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; EPOCH protocol
  • [Other-IDs] NLM/ NIHMS71491; NLM/ PMC2607005
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6. Bolaman Z, Kadiköylü G, Polatli M, Barutca S, Culhaci N, Sentürk T: Migratory nodules in the lung: lymphomatoid granulomatosis. Leuk Lymphoma; 2003 Jan;44(1):197-200
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  • [Title] Migratory nodules in the lung: lymphomatoid granulomatosis.
  • On physical examination moderate hepatosplenomegaly and crackles most notably on the basal region of the right lung were evident.
  • The histopathological diagnosis of the open lung biopsy was lymphomatoid granulomatosis (LG) with a marked angioinvasive lymphocytic perivascular and peribronchial infiltration pattern.
  • No response could have been achieved under combination chemotherapy and the patient died from progressive disease.
  • LG is a rare disease and a difficult diagnosis in the routine clinical practice.
  • This report emphasises that, LG should be considered especially when there are migratory nodules of varying sizes in lungs.
  • [MeSH-major] Lung Neoplasms / pathology. Lymphomatoid Granulomatosis / diagnosis. Neoplasm Invasiveness / diagnosis

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  • (PMID = 12691164.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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7. Cadranel J, Wislez M, Antoine M: Primary pulmonary lymphoma. Eur Respir J; 2002 Sep;20(3):750-62
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  • Three distinct entities are now covered by the definition of primary pulmonary clonal lymphoid proliferation.
  • The aim of this review is to describe the pathophysiological, diagnostic, prognostic and therapeutic aspects of these three entities.
  • Low-grade pulmonary B-cell lymphoma is the most frequent form of primary pulmonary clonal lymphoid proliferation.
  • It arises from mucosa-associated lymphoid tissue.
  • The prognosis is excellent, but treatment is controversial (simple monitoring, surgery or single-agent chemotherapy).
  • High-grade pulmonary B-cell lymphoma is far rarer and usually occurs in individuals with an underlying disorder (e.g. immunodeficiency).
  • The prognosis is poor and therapeutic options depend on the underlying disorder.
  • The inclusion of lymphomatoid granulomatosis in the definition of primary pulmonary lymphomas is controversial.
  • The prognosis is extremely variable, with some authors reporting complete remission with steroids and cyclophosphamide and others reporting failure of combination chemotherapy.
  • [MeSH-major] Lung Neoplasms. Lymphoma, B-Cell. Lymphomatoid Granulomatosis
  • [MeSH-minor] Humans. Lymphoma, B-Cell, Marginal Zone / diagnosis. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, B-Cell, Marginal Zone / therapy. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / pathology. Lymphoma, Non-Hodgkin / therapy

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  • (PMID = 12358356.001).
  • [ISSN] 0903-1936
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 108
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8. Jung KH, Sung HJ, Lee JH, Lee KY, Shin JS, Kim KM, Kim YS, Shin C, Kim JH: A case of pulmonary lymphomatoid granulomatosis successfully treated by combination chemotherapy with rituximab. Chemotherapy; 2009;55(5):386-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of pulmonary lymphomatoid granulomatosis successfully treated by combination chemotherapy with rituximab.
  • Lymphomatoid granulomatosis (LYG) is a rare angiocentric and angiodestructive lymphoproliferative disease characterized by Epstein-Barr virus-positive B cells admixed with reactive T cells.
  • LYG most commonly affects the lung but can also involve other extrapulmonary sites.
  • Standard treatment for LYG has not yet been established.
  • Despite combination chemotherapy, the overall prognosis is poor.
  • We report the case of a 70-year-old male patient with pulmonary LYG, who showed rapid remission of the disease after combination chemotherapy with rituximab.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lung Neoplasms / drug therapy. Lymphomatoid Granulomatosis / drug therapy
  • [MeSH-minor] Aged. Antibodies, Monoclonal, Murine-Derived. Cyclophosphamide / administration & dosage. Cyclophosphamide / therapeutic use. Humans. Male. Prednisolone / administration & dosage. Prednisolone / therapeutic use. Rituximab. Vincristine / administration & dosage. Vincristine / therapeutic use

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19752554.001).
  • [ISSN] 1421-9794
  • [Journal-full-title] Chemotherapy
  • [ISO-abbreviation] Chemotherapy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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9. Moudir-Thomas C, Foulet-Roge A, Plat M, Kaswin R, Lepic P, Solal-Celigny P, Lebas FX: [Efficacy of rituximab in lymphomatoid granulomatosis]. Rev Mal Respir; 2004 Dec;21(6 Pt 1):1157-61
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  • [Title] [Efficacy of rituximab in lymphomatoid granulomatosis].
  • INTRODUCTION: Lymphomatoid Granulomatosis is a rare and serious disease, now considered to be a B-cell lymphoma, which is frequently associated with Epstein-Barr virus infection.
  • There is no consensus on treatment, which is usually based on steroid therapy, either alone or combined with cyclophosphamide and combination chemotherapy.
  • The diagnosis of Lymphomatoid Granulomatosis was made on the basis of surgical lung biopsy.
  • Treatment with anti CD 20 monoclonal antibodies (rituximab) led initially to a reduction in parenchymal abnormalities and mediastinal adenopathy.
  • CONCLUSION: This treatment, recently used in Lymphomatoid Granulomatosis with pulmonary involvement, has shown promising results.
  • Rituximab can be used in combination chemotherapy as standard treatment for aggressive B-cell lymphoma.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Lung Diseases / drug therapy. Lymphomatoid Granulomatosis / drug therapy

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  • (PMID = 15767962.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
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10. Al-Arfaj AS: Lymphomatoid granulomatosis with long survival. Saudi Med J; 2001 Jun;22(6):541-3
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  • [Title] Lymphomatoid granulomatosis with long survival.
  • We present a case of lymphomatoid granulomatosis presenting in a 35-year-old Saudi lady with long survival.
  • She responded to treatment with intermittent cyclophosphamide infusion in addition to corticosteroids.
  • This is the first case of lymphomatoid granulomatosis to be reported in the Arab world.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Cyclophosphamide / administration & dosage. Lung Neoplasms / drug therapy. Lymphomatoid Granulomatosis / drug therapy. Prednisolone / administration & dosage

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  • (PMID = 11426249.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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11. Friedrichs B, Thiel E: [Relapsed pulmonary lymphomatoid granulomatosis grade III: curative treatment with radioimmune therapy and autologous stem cell transplantation]. Dtsch Med Wochenschr; 2010 Sep;135(38):1857-60
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  • [Title] [Relapsed pulmonary lymphomatoid granulomatosis grade III: curative treatment with radioimmune therapy and autologous stem cell transplantation].
  • [Transliterated title] Pulmonale lymphomatoide Granulomatose Grad III: kurativer Therapieansatz mit Radioimmuntherapie und autologer Stammzelltransplantation.
  • INVESTIGATIONS: A chest X-ray and subsequent computed tomography (CT) scans showed a lesion measuring 10×8 cm in the right upper pulmonary lobe.
  • These findings were consistent with lymphomatoid granulomatosis grade III.
  • TREATMENT AND COURSE: After 6 cycles of rituximab, cyclophosphamide, doxorubicin, vincristin and prednisolone (R-CHOP), an early relapse developed which was treated with rituximab, ifosphamid, methotrexate and etoposide.
  • Good partial remission was achieved after consolidating high-dose chemotherapy followed by autologous stem cell transplantation (ASCT).
  • After two years of rituximab maintenance treatment positron emission tomography (PET-CT) revealed an increase of metabolic activity.
  • A second high-dose therapy was then combined with Y-90 ibritumomab tiuxetan, which was well tolerated.
  • During remission the previously present lymphoma lesion of the lung was resected.
  • Histology did not reveal any residual active lymphomatoid granulomatosis.
  • CONCLUSIONS: Combination of Y-90 ibritumomab tiuxetan and high-dose chemotherapy followed by ASCT may offer an efficacious and well-tolerated targeted treatment approach for patients with relapsed lymphomatoid granulomatosis.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hematopoietic Stem Cell Transplantation. Lung Neoplasms / therapy. Lymphomatoid Granulomatosis / therapy. Neoplasm Recurrence, Local / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Dose-Response Relationship, Drug. Female. Humans. Image Processing, Computer-Assisted. Infant. Lung / pathology. Pneumonectomy. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20842604.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / ibritumomab tiuxetan
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12. Lemieux J, Bernier V, Martel N, Delage R: Autologous hematopoietic stem cell transplantation for refractory lymphomatoid granulomatosis. Hematology; 2002 Dec;7(6):355-8
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  • [Title] Autologous hematopoietic stem cell transplantation for refractory lymphomatoid granulomatosis.
  • Lymphomatoid granulomatosis (LG) is a rare lymphoproliferative disorder.
  • There is no standard therapy for refractory patient.
  • Here we present the case of a patient with LG of the lung and the brain who was refractory to polychemotherapy.
  • This represents the first case of high-dose chemotherapy with hematopoietic stem cell support in this disease.
  • [MeSH-major] Hematopoietic Stem Cell Transplantation. Lymphomatoid Granulomatosis / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Diagnostic Imaging. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / therapy. Male. Remission Induction. Salvage Therapy. Transplantation, Autologous

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  • (PMID = 12475740.001).
  • [ISSN] 1024-5332
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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13. Moertel CL, Carlson-Green B, Watterson J, Simonton SC: Lymphomatoid granulomatosis after childhood acute lymphoblastic leukemia: report of effective therapy. Pediatrics; 2001 May;107(5):E82
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  • [Title] Lymphomatoid granulomatosis after childhood acute lymphoblastic leukemia: report of effective therapy.
  • Lymphomatoid granulomatosis, a rare condition in children, affects the lungs primarily but may have significant extrapulmonary manifestations, especially in the central nervous system.
  • We report a case of lymphomatoid granulomatosis with onset after the completion of chemotherapy for childhood acute lymphoblastic leukemia.
  • Two months after treatment ended, the 7-year-old girl developed splenomegaly, cervical adenopathy, and bilateral interstitial pulmonary infiltrates.
  • A computed tomography scan of the head was normal, but her pulmonary infiltrates had become nodular.
  • A computed tomography-guided biopsy of 1 of the nodules revealed cellular interstitial pneumonitis.
  • Five months after her initial symptoms, she developed tonic pupil and a decreased level of consciousness.
  • Needle biopsies of the brain were carried out, yielding the diagnosis of severe chronic inflammatory changes focally consistent with granuloma.
  • Open-lung biopsy revealed lymphomatoid granulomatosis.
  • Lymphoma-directed therapy was initiated, and the patient had complete resolution of pulmonary and cerebral nodules 5 months later.
  • No intrathecal chemotherapy was administered, and radiation therapy was not necessary.
  • Neuropsychological testing obtained after completion of therapy revealed an improvement in attention, coordination, and fine motor speed over time.
  • [MeSH-major] Brain Neoplasms / diagnosis. Lung Neoplasms / diagnosis. Lymphomatoid Granulomatosis / diagnosis. Neoplasms, Second Primary / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Child, Preschool. Female. Humans. Magnetic Resonance Imaging


14. Johnston A, Coyle L, Nevell D: Prolonged remission of refractory lymphomatoid granulomatosis after autologous hemopoietic stem cell transplantation with post-transplantation maintenance interferon. Leuk Lymphoma; 2006 Feb;47(2):323-8
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  • [Title] Prolonged remission of refractory lymphomatoid granulomatosis after autologous hemopoietic stem cell transplantation with post-transplantation maintenance interferon.
  • Lymphomatoid granulomatosis (LYG) is a rare Epstein Barr virus (EBV)-associated lymphoproliferative disease.
  • Even with combination chemotherapy, mortality is high.
  • There is no standard therapy for relapsed or refractory disease.
  • There is only one report in the literature of a complete remission with high-dose chemotherapy and autologous stem cell transplantation.
  • This study presents the case of a patient with progressive LYG, who was successfully treated with autologous stem cell transplantation after conditioning with high-dose chemotherapy and total body irradiation.
  • After transplantation, maintenance therapy with interferon alpha 2a was administered for 3.75 years.
  • This is the first report of a durable (>1 year) complete remission after high-dose chemotherapy and autologous stem cell transplantation in LYG.
  • The role of high-dose chemotherapy and autologous stem cell transplantation in relapsed or refractory cases merits further evaluation.
  • The exact place of interferon in treatment of LYG remains to be clarified but is promising.
  • [MeSH-major] Hematopoietic Stem Cell Transplantation. Interferon-alpha / administration & dosage. Lung Neoplasms / etiology. Lung Neoplasms / therapy. Lymphomatoid Granulomatosis / complications. Lymphomatoid Granulomatosis / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Disease Progression. Humans. Male. Middle Aged. Recombinant Proteins. Remission Induction / methods. Transplantation, Autologous. Treatment Outcome. Whole-Body Irradiation

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  • (PMID = 16321865.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Interferon-alpha; 0 / Recombinant Proteins; 76543-88-9 / interferon alfa-2a
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15. Shimada K, Matsui T, Kawakami M, Nakayama H, Ozawa Y, Mitomi H, Tohma S: Methotrexate-related lymphomatoid granulomatosis: a case report of spontaneous regression of large tumours in multiple organs after cessation of methotrexate therapy in rheumatoid arthritis. Scand J Rheumatol; 2007 Jan-Feb;36(1):64-7
Hazardous Substances Data Bank. METHOTREXATE .

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  • [Title] Methotrexate-related lymphomatoid granulomatosis: a case report of spontaneous regression of large tumours in multiple organs after cessation of methotrexate therapy in rheumatoid arthritis.
  • Computed tomography (CT) showed multiple tumours in both lungs, the liver, and the spleen.
  • The right lung tumour was 8 cm in diameter with a cavity.
  • Biopsy of the lung and liver revealed lymphomatoid granulomatosis (LG) and diffuse large B-cell lymphoma (DLBCL).
  • These lesions spontaneously regressed after withdrawal of methotrexate without any therapy for the lymphoma.
  • This is the first report of self-limiting LG in a patient, complicated with methotrexate-treated RA.
  • [MeSH-major] Antirheumatic Agents / adverse effects. Arthritis, Rheumatoid / drug therapy. Lymphoma, Non-Hodgkin / chemically induced. Lymphomatoid Granulomatosis / chemically induced. Methotrexate / adverse effects


16. Sladkopevtsev AS, Mikhailova LP, Makarova OV, Kovaleva VL, Veselova NI: Antiinflammatory effect of russian-made budesonide in experimental noninfectious pulmonary granulomatosis. Bull Exp Biol Med; 2001 May;131(5):473-4

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  • [Title] Antiinflammatory effect of russian-made budesonide in experimental noninfectious pulmonary granulomatosis.
  • We studied the antiinflammatory effect of a Russian-made glucocorticoid budesonide administered by inhalation and intraperitoneal injection to rats with experimental noninfectious pulmonary granulomatosis.
  • Intraperitoneal injection, in contrast to inhalation, produced a systemic effect manifested in suppression of hyperplasia of non-encapsulated lymphoid formations in the mucosa.
  • [MeSH-major] Anti-Inflammatory Agents / therapeutic use. Budesonide / therapeutic use. Lymphomatoid Granulomatosis / drug therapy
  • [MeSH-minor] Administration, Inhalation. Animals. Bronchoalveolar Lavage Fluid. Hyperplasia / drug therapy. Infusions, Parenteral. Lung / drug effects. Male. Rats. Rats, Wistar. Time Factors

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  • (PMID = 11550057.001).
  • [ISSN] 0007-4888
  • [Journal-full-title] Bulletin of experimental biology and medicine
  • [ISO-abbreviation] Bull. Exp. Biol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 51333-22-3 / Budesonide
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17. Marica C, Galbenu P, Galie N, Tănăsescu M: [Pulmonary benign lymphocytic angiitis and granulomatosis--a benign lymphoproliferative condition]. Pneumologia; 2002 Oct-Dec;51(4):302-5
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  • [Title] [Pulmonary benign lymphocytic angiitis and granulomatosis--a benign lymphoproliferative condition].
  • [Transliterated title] BLAG pulmonar--o condiţie limfoproliferativă benignă.
  • BLAG--benign lymphocytic angiitis and granulomatosis is a granulomatosis disease which histologically presents a dense infiltrate of lympnoid cells that disturbes the normal alveolar architecture.
  • Faint granuloma formation occur within the lympnoid infiltrate.
  • The treatment was a combination of cyclophosphamide and prednisone.
  • Follow up information after 9 month of treatment show a generally favorable evolution (clinical and radiological).
  • [MeSH-major] Lung Diseases / pathology. Lymphomatoid Granulomatosis / pathology. Vasculitis / pathology
  • [MeSH-minor] Adult. Anti-Inflammatory Agents / therapeutic use. Biopsy. Cyclophosphamide / therapeutic use. Drug Therapy, Combination. Female. Humans. Immunosuppressive Agents / therapeutic use. Lung / pathology. Prednisone / therapeutic use. Treatment Outcome

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  • (PMID = 12693170.001).
  • [ISSN] 2067-2993
  • [Journal-full-title] Pneumologia (Bucharest, Romania)
  • [ISO-abbreviation] Pneumologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Immunosuppressive Agents; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone
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18. Güven A, Baskin D: Lymphomatoid granulomatosis in a boy with long-term follow-up. Pediatr Hematol Oncol; 2001 Sep;18(6):377-82
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  • [Title] Lymphomatoid granulomatosis in a boy with long-term follow-up.
  • Lymphomatoid granulomatosis is an angiocentric lymphoreticular proliferative disease.
  • The authors describe a patient who presented at the age of 12 years with pulmonary nodules and hepatosplenomegaly and was followed up for 6 years, and who subsequently developed lymphoma after cessation of therapy.
  • [MeSH-major] Lymphomatoid Granulomatosis / diagnosis
  • [MeSH-minor] Child. Hodgkin Disease. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Male. Neoplasms, Second Primary. Skin Neoplasms / diagnosis. Skin Neoplasms / drug therapy

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  • (PMID = 11554232.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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19. Kameda H, Okuyama A, Tamaru J, Itoyama S, Iizuka A, Takeuchi T: Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis. Clin Rheumatol; 2007 Sep;26(9):1585-9
Hazardous Substances Data Bank. METHOTREXATE .

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  • [Title] Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis.
  • We report on a patient of rheumatoid arthritis (RA) who sequentially developed an axillary mass and a fatal interstitial pneumonia during a 2-year course of methotrexate (MTX) therapy.
  • Autopsy revealed a systemic lymph node involvement and the diagnosis of Epstein-Barr virus (EBV)-related lymphoproliferative disease (LPD) with the features of lymphomatoid granulomatosis was made.
  • The lung tissue specimens revealed a typical diffuse alveolar damage (DAD), and small nodules consisting of atypical B lymphocytes showing positive staining for EBV were sparsely recognized only in basal lungs.
  • This is the first report of a RA patient receiving MTX therapy sequentially developing MTX-associated lymphomatoid granulomatosis and DAD.
  • [MeSH-minor] Aged. Arthritis, Rheumatoid / drug therapy. Fatal Outcome. Humans. Lymphomatoid Granulomatosis / etiology. Male. Pneumonia / chemically induced. Pulmonary Alveoli / pathology. Pulmonary Alveoli / virology

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  • (PMID = 17200802.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; YL5FZ2Y5U1 / Methotrexate
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20. Rakusić N, Krmpotić D, Hećimović A, Boras Z, Vrabec-Branica B, Dzebro S, Rakusić N, Resković T, Rakusić N: Lymphomatoid granulomatosis in a 23-year-old man--cytological and histological typing and rapid response to steroid and cyclophosphamide combination therapy. Coll Antropol; 2010 Mar;34(1):279-83
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  • [Title] Lymphomatoid granulomatosis in a 23-year-old man--cytological and histological typing and rapid response to steroid and cyclophosphamide combination therapy.
  • Lymphomatoid granulomatosis (LG) is currently called as extranodal angiocentric and angiodestructive immunoproliferative disorder with various degrees of histological differentiation and disease severity.
  • We report the case of a 23-year-old man clinically presented with fever, sweating, and physical intolerance, and bilateral pulmonary infiltrates of nodular type and destructive changes on the chest X-ray, previously treated with antituberculotics for 1.5 month.
  • As the disease showed progression, diagnostic procedures extended to transbronchial lung biopsy and percutaneous fine needle aspiration with cytological and histological analysis of collected specimens, all being not conclusive enough.
  • LG was confirmed by open lung biopsy, followed by induction of corticosteroids and cyclophosphamide therapy.
  • [MeSH-major] Adrenal Cortex Hormones / administration & dosage. Cyclophosphamide / administration & dosage. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology. Lymphomatoid Granulomatosis / drug therapy. Lymphomatoid Granulomatosis / pathology
  • [MeSH-minor] Antineoplastic Agents, Alkylating / administration & dosage. B-Lymphocytes / pathology. B-Lymphocytes / virology. Biopsy, Fine-Needle. Drug Therapy, Combination. Epstein-Barr Virus Infections / pathology. Humans. Lung / pathology. Male. Remission Induction. Young Adult

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  • (PMID = 20437644.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antineoplastic Agents, Alkylating; 8N3DW7272P / Cyclophosphamide
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21. Ishiura H, Morikawa M, Hamada M, Watanabe T, Kako S, Chiba S, Motokura T, Hangaishi A, Shibahara J, Akahane M, Goto J, Kwak S, Kurokawa M, Tsuji S: Lymphomatoid granulomatosis involving central nervous system successfully treated with rituximab alone. Arch Neurol; 2008 May;65(5):662-5
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  • [Title] Lymphomatoid granulomatosis involving central nervous system successfully treated with rituximab alone.
  • OBJECTIVE: To report the successful treatment of a patient with lymphomatoid granulomatosis (LYG), a rare Epstein-Barr virus-positive lymphoproliferative disorder, using rituximab (anti-CD20 monoclonal antibody).
  • The prognosis for LYG has been reported to be poor, and no satisfactory treatment has been established.
  • Because central nervous system (CNS) involvement of LYG has been known to show poor prognosis, the establishment of an effective treatment for CNS LYG with mild adverse effects is desired.
  • CONCLUSION: Rituximab monotherapy was effective in treating the patient; hence, rituximab should be considered as the initial treatment against LYG involving the CNS.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Central Nervous System Neoplasms / drug therapy. Lung Neoplasms / drug therapy. Lymphomatoid Granulomatosis / drug therapy
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Brain / drug effects. Brain / pathology. Brain / physiopathology. Central Nervous System / drug effects. Central Nervous System / pathology. Central Nervous System / physiopathology. Epstein-Barr Virus Infections / complications. Humans. Immunologic Factors / administration & dosage. Lung / drug effects. Lung / pathology. Lung / physiopathology. Lymphocytes / immunology. Lymphocytes / pathology. Lymphocytes / virology. Magnetic Resonance Imaging. Male. Middle Aged. Paraparesis, Spastic / drug therapy. Paraparesis, Spastic / etiology. Paraparesis, Spastic / physiopathology. Remission Induction. Rituximab. Spinal Cord / drug effects. Spinal Cord / pathology. Spinal Cord / physiopathology. Treatment Outcome

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  • (PMID = 18474745.001).
  • [ISSN] 1538-3687
  • [Journal-full-title] Archives of neurology
  • [ISO-abbreviation] Arch. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunologic Factors; 4F4X42SYQ6 / Rituximab
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22. Tateishi T, Tanaka K, Ito Y, Mitsuo K: [Case of X-linked lymphoproliferative syndrome (XLP) with multiple nodular lesions in the brain]. Rinsho Shinkeigaku; 2006 Apr;46(4):254-60
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  • He developed agammaglobulinemia following Epstein-Barr virus infection at 3-year-old, and thereafter was administered 7.5g of immunoglobulin every 3 weeks with a diagnosis of XLP.
  • Neurological examination revealed disorientation of time, and bilateral gaze-evoked nystagmus.
  • The needle lung biopsy was performed, which showed infiltration of lymphocytes around the vessels.
  • The histological findings excluded intravascular malignant lymphoma and lymphomatoid granulomatosis.
  • Therefore we diagnosed lymphoid vasculitis.
  • The patient developed pancytopenia caused by hemophagocytic syndrome 48 days after admission and was treated with 1 g of methylprednisolone per day for 3 days and a tapered dose of steroid (500 mg to 125 mg of methylprednisolone and 60 mg to 10mg of predonisolone) for 21 days, which resulted in the improvement of clinical features (hemophagocytic syndrome and central nervous system symptoms) and the abnormal CSF findings.
  • The multple nodular lesions in the brain and the lungs shrank 1 month after treatment and disappeared 11 months later.
  • There are few reports concerning lymphoid vasculitis with XLP, and no effective treatment has been described.
  • Our case suggests that steroid therapy may be useful for the treatment of lymphoid vasculitis in XLP.
  • [MeSH-minor] Adult. Brain / pathology. Humans. Lung / pathology. Lung / radiography. Lymphohistiocytosis, Hemophagocytic / drug therapy. Lymphohistiocytosis, Hemophagocytic / etiology. Magnetic Resonance Imaging. Male. Methylprednisolone / administration & dosage. Prednisolone / administration & dosage. Pulse Therapy, Drug. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16768091.001).
  • [ISSN] 0009-918X
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 9PHQ9Y1OLM / Prednisolone; X4W7ZR7023 / Methylprednisolone
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23. Hu YH, Hsiao LT, Yang CF, Chiou TJ, Liu JH, Gau JP, Yen CC, Chou TY, Hsu WH, Chen PM, Tzeng CH: Prognostic factors of Chinese patients with primary pulmonary non-Hodgkin's lymphoma: the single-institute experience in Taiwan. Ann Hematol; 2009 Sep;88(9):839-46
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  • The histological subtypes included marginal zone B-cell lymphoma of mucosa-associated lymphoid tissues (MALT) in 12 patients (54%), diffuse large B-cell lymphoma in nine (41%), and one case of lymphomatoid granulomatosis.
  • Eighteen patients (82%) received chemotherapy.
  • The 5-year rates of overall survival (OS) were 91% and 21% for MALT and non-MALT types of PPL, respectively.
  • [MeSH-major] Lung Neoplasms / classification. Lung Neoplasms / diagnosis. Lymphoma, Non-Hodgkin / classification. Lymphoma, Non-Hodgkin / diagnosis

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  • (PMID = 19139892.001).
  • [ISSN] 1432-0584
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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24. Rao R, Vugman G, Leslie WT, Loew J, Venugopal P: Lymphomatoid granulomatosis treated with rituximab and chemotherapy. Clin Adv Hematol Oncol; 2003 Nov;1(11):658-60; discussion 660
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  • [Title] Lymphomatoid granulomatosis treated with rituximab and chemotherapy.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Immunotherapy. Lymphomatoid Granulomatosis / drug therapy
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived. Antigens, CD20 / analysis. Antigens, Neoplasm / analysis. Cerebral Cortex / pathology. Combined Modality Therapy. Cranial Irradiation. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Epilepsy, Tonic-Clonic / etiology. Epstein-Barr Virus Infections / complications. Herpesvirus 4, Human / isolation & purification. Humans. Lung Neoplasms / chemistry. Lung Neoplasms / drug therapy. Lung Neoplasms / virology. Magnetic Resonance Imaging. Male. Methotrexate / administration & dosage. Prednisone / administration & dosage. Remission Induction. Rituximab. Vincristine / administration & dosage. Vision Disorders / etiology

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  • (PMID = 16258464.001).
  • [ISSN] 1543-0790
  • [Journal-full-title] Clinical advances in hematology & oncology : H&O
  • [ISO-abbreviation] Clin Adv Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD20; 0 / Antigens, Neoplasm; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate; CHOP protocol
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25. Yazdi AS, Metzler G, Weyrauch S, Berneburg M, Bitzer M, Müller-Hermelink HK, Röcken M: Lymphomatoid granulomatosis induced by imatinib-treatment. Arch Dermatol; 2007 Sep;143(9):1222-3
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  • [Title] Lymphomatoid granulomatosis induced by imatinib-treatment.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Lymphomatoid Granulomatosis / chemically induced. Piperazines / adverse effects. Pyrimidines / adverse effects. Skin Diseases / chemically induced
  • [MeSH-minor] Aged, 80 and over. Benzamides. Female. Humans. Imatinib Mesylate. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Lung Diseases / chemically induced. Lung Diseases / pathology

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  • (PMID = 17875901.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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26. Panchal R, Avery R, Mehta AC, Castillo JR, Farver C, Aboussouan LS: A young man with a cough, an abnormal chest radiograph, and multiple skin lesions. Cleve Clin J Med; 2006 Mar;73(3):273-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Antifungal Agents / therapeutic use. Blastomycosis / diagnosis. Blastomycosis / drug therapy. Cough / radiography. Face. Itraconazole / therapeutic use. Lung / radiography
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Histoplasmosis / diagnosis. Humans. Lymphomatoid Granulomatosis / diagnosis. Male. Practice Guidelines as Topic. Sarcoidosis / diagnosis. Sporotrichosis / diagnosis

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  • (PMID = 16548450.001).
  • [ISSN] 0891-1150
  • [Journal-full-title] Cleveland Clinic journal of medicine
  • [ISO-abbreviation] Cleve Clin J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antifungal Agents; 304NUG5GF4 / Itraconazole
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27. Robak T, Kordek R, Urbanska-Rys H, Robak P, Bartkowiak J, Bednarek A, Chudobinski C, Chojnowski K: High activity of rituximab combined with cladribine and cyclophosphamide in a patient with pulmonary lymphomatoid granulomatosis and bone marrow involvement. Leuk Lymphoma; 2006 Aug;47(8):1667-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High activity of rituximab combined with cladribine and cyclophosphamide in a patient with pulmonary lymphomatoid granulomatosis and bone marrow involvement.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphomatoid Granulomatosis / drug therapy
  • [MeSH-minor] Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Bone Marrow Diseases. Cladribine / therapeutic use. Cyclophosphamide / therapeutic use. Female. Humans. Lung Diseases. Middle Aged. Rituximab

  • Genetic Alliance. consumer health - Lymphomatoid granulomatosis.
  • Hazardous Substances Data Bank. RITUXIMAB .
  • Hazardous Substances Data Bank. CLADRIBINE .
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  • (PMID = 16966281.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 47M74X9YT5 / Cladribine; 4F4X42SYQ6 / Rituximab; 8N3DW7272P / Cyclophosphamide
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28. Hu YH, Liu CY, Chiu CH, Hsiao LT: Successful treatment of elderly advanced lymphomatoid granulomatosis with rituximab-CVP combination therapy. Eur J Haematol; 2007 Feb;78(2):176-7
Hazardous Substances Data Bank. VINCRISTINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of elderly advanced lymphomatoid granulomatosis with rituximab-CVP combination therapy.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Cyclophosphamide / therapeutic use. Lung Diseases / drug therapy. Lymphomatoid Granulomatosis / drug therapy. Prednisolone / therapeutic use. Vincristine / therapeutic use
  • [MeSH-minor] Aged. Antibodies, Monoclonal, Murine-Derived. Drug Therapy, Combination. Female. Humans. Remission Induction. Rituximab

  • Genetic Alliance. consumer health - Lymphomatoid granulomatosis.
  • MedlinePlus Health Information. consumer health - Lung Diseases.
  • Hazardous Substances Data Bank. RITUXIMAB .
  • Hazardous Substances Data Bank. CYCLOPHOSPHAMIDE .
  • Hazardous Substances Data Bank. PREDNISOLONE .
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  • [CommentOn] Eur J Haematol. 2005 Aug;75(2):172-3 [16000136.001]
  • [CommentOn] Eur J Haematol. 2005 Mar;74(3):263-6 [15693798.001]
  • (PMID = 17313566.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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