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1. Tlacuilo-Parra JA, Guevara-Gutiérrez E, Salazar-Páramo M: Acquired ichthyosis associated with systemic lupus erythematosus. Lupus; 2004;13(4):270-3
Hazardous Substances Data Bank. PREDNISONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Acquired ichthyosis is an uncommon disease, it is characterized by symmetric scaling of the skin, which ranges from minor roughness and dryness to the desquamation of large plaques.
  • It has been associated with various systemic diseases, although malignant conditions, especially Hodgkin's lymphoma are the most commonly cited.
  • Drugs, HIV infection and autoimmune diseases such as dermatomyositis and mixed connective tissue disease have also been associated, and it has only rarely been found among patients with systemic lupus erythematosus (SLE).
  • Herein, we report a patient with active SLE who developed a generalized acquired ichthyosis corroborated with skin biopsy, which completely disappeared after treatment.
  • The association of autoimmune conditions with acquired ichthyosis could indicate that an abnormal host immune response, probably against components of the granular cell layer in particular the keratohyalin granules, may have a role in the pathogenesis.
  • Thus, this finding may be a relevant cutaneous marker for an autoimmune origin.
  • [MeSH-minor] Administration, Oral. Adult. Cyclophosphamide / administration & dosage. Female. Humans. Immunosuppressive Agents / administration & dosage. Lupus Nephritis / drug therapy. Prednisone / administration & dosage. Pulse Therapy, Drug. Treatment Outcome

2. Win N, Tiwari D, Keevil VL, Needs M, Lakhani A: Mixed-type autoimmune haemolytic anaemia: unusual cases and a case associated with splenic T-cell angioimmunoblastic non-Hodgkin's lymphoma. Hematology; 2007 Apr;12(2):159-62
Hazardous Substances Data Bank. VINCRISTINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed-type autoimmune haemolytic anaemia: unusual cases and a case associated with splenic T-cell angioimmunoblastic non-Hodgkin's lymphoma.
  • The diagnosis of mixed-type autoimmune haemolytic anaemia (AIHA) is based on demonstrating the presence of "warm" IgG auto-antibody and "low titre" ( < 64 at 4 degrees C), "high thermal amplitude" (reacting at or >30 degrees C) "cold" IgM auto-antibody.
  • Mixed-type AIHA is uncommon.
  • Red cell agglutination on the peripheral blood film is a common finding in mixed-type AIHA and can lead, initially, to a mis-diagnosis of cold haemmagglutinin disease (CHAD).
  • Mixed-type AIHA is rare and can be idiopathic or secondary, often associated with systemic lupus erythematosus (SLE) and lymphoma.
  • In general, patients with mixed-type AIHA show a dramatic response to steroid therapy and frequently require few or no transfusions.
  • We report two unusual cases of mixed-type AIHA.
  • Case two, we believe, is the first reported case of splenic T cell angioimmunoblastic non-Hodgkins lymphoma (NHL) associated with mixed-type AIHA.
  • DAT tested with monospecific reagents, and thorough serological investigations is required to reach the diagnosis of mixed-type AIHA.
  • Awareness of this condition is important as management may be different from either treating warm AIHA or CHAD.
  • [MeSH-major] Anemia, Hemolytic, Autoimmune / etiology. Anti-Inflammatory Agents / adverse effects. Lymphoma, T-Cell / complications. Paraneoplastic Syndromes / etiology. Prednisolone / adverse effects. Splenic Neoplasms / complications
  • [MeSH-minor] Aged. Antibodies, Anti-Idiotypic / blood. Antibodies, Anti-Idiotypic / immunology. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Autoantibodies / blood. Autoantibodies / immunology. Combined Modality Therapy. Complement C3d / immunology. Coombs Test. Cryoglobulins / analysis. Cryoglobulins / immunology. Cyclophosphamide / administration & dosage. Diagnosis, Differential. Erythrocyte Transfusion. Fatal Outcome. Female. Humans. Immunoglobulin G / blood. Immunoglobulin G / immunology. Immunoglobulin M / blood. Immunoglobulin M / immunology. Immunoglobulins, Intravenous / therapeutic use. Immunosuppressive Agents / therapeutic use. Immunotherapy. Male. Osteoarthritis / drug therapy. Prednisone / administration & dosage. Rituximab. Splenectomy. Temperature. Vincristine / administration & dosage

  • Hazardous Substances Data Bank. RITUXIMAB .
  • Hazardous Substances Data Bank. CYCLOPHOSPHAMIDE .
  • Hazardous Substances Data Bank. PREDNISOLONE .
  • Hazardous Substances Data Bank. PREDNISONE .
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  • (PMID = 17454198.001).
  • [ISSN] 1607-8454
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Autoantibodies; 0 / Cryoglobulins; 0 / Immunoglobulin G; 0 / Immunoglobulin M; 0 / Immunoglobulins, Intravenous; 0 / Immunosuppressive Agents; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80295-45-0 / Complement C3d; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VB0R961HZT / Prednisone; COP protocol 2
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