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1. Nieuwenhuis RF, Ossewaarde JM, van der Meijden WI, Neumann HA: Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: effective treatment with 1 g azithromycin. Sex Transm Infect; 2003 Dec;79(6):453-5
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  • [Title] Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: effective treatment with 1 g azithromycin.
  • The incidence of lymphogranuloma venereum (LGV) is low in the western world.
  • Treatment with a single dose of 1 g azithromycin was effective.
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. Anti-Bacterial Agents / administration & dosage. Azithromycin / administration & dosage. HIV Infections / complications. HIV-1. Lymphogranuloma Venereum / complications
  • [MeSH-minor] Adult. Anus Diseases / drug therapy. Anus Diseases / microbiology. Chlamydia trachomatis / isolation & purification. Groin. Humans. Lymphadenitis / microbiology. Male. Ulcer / drug therapy. Ulcer / microbiology


2. Celum CL: Sexually transmitted infections and HIV: epidemiology and interventions. Top HIV Med; 2010 Oct-Nov;18(4):138-42
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  • Herpes simplex virus type 2 infection has highly variable clinical manifestations, and diagnosis is needed before considering episodic or suppressive treatment.
  • However, suppressive treatment of herpes simplex virus type 2 infection has not been shown to reduce risk of HIV acquisition.
  • The increase in syphilis rates continues; screening is inexpensive and treatment is highly effective.
  • Quinolone resistance rates in gonorrhea are increasing, complicating treatment in some locales.
  • Cases of proctitis caused by chlamydial infection with lymphogranuloma venereum strains have been observed in the United States and Europe.
  • [MeSH-minor] Female. Genital Diseases, Female / diagnosis. Genital Diseases, Female / drug therapy. Genital Diseases, Female / epidemiology. Genital Diseases, Male / diagnosis. Genital Diseases, Male / drug therapy. Genital Diseases, Male / epidemiology. Gonorrhea / diagnosis. Gonorrhea / drug therapy. Gonorrhea / epidemiology. Humans. Male. Syphilis / diagnosis. Syphilis / drug therapy. Syphilis / epidemiology


3. Workowski KA, Berman S, Centers for Disease Control and Prevention (CDC): Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep; 2010 Dec 17;59(RR-12):1-110
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sexually transmitted diseases treatment guidelines, 2010.
  • These guidelines for the treatment of persons who have or are at risk for sexually transmitted diseases (STDs) were updated by CDC after consultation with a group of professionals knowledgeable in the field of STDs who met in Atlanta on April 18-30, 2009.
  • The information in this report updates the 2006 Guidelines for Treatment of Sexually Transmitted Diseases (MMWR 2006;55[No. RR-11]).
  • 2) new treatment recommendations for bacterial vaginosis and genital warts;.
  • 4) the role of Mycoplasma genitalium and trichomoniasis in urethritis/cervicitis and treatment-related implications;.
  • 5) lymphogranuloma venereum proctocolitis among men who have sex with men;.

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  • [CommentIn] Ann Emerg Med. 2011 Jul;58(1):67-8 [21689567.001]
  • [ErratumIn] MMWR Recomm Rep. 2011 Jan 14;60(1):18. Dosage error in article text
  • (PMID = 21160459.001).
  • [ISSN] 1545-8601
  • [Journal-full-title] MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports
  • [ISO-abbreviation] MMWR Recomm Rep
  • [Language] ENG
  • [Grant] United States / NCATS NIH HHS / TR / UL1 TR000077
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] United States
  • [Investigator] Workowski KA; Bauer H; Bachman L; Burstein G; Eckert L; Geisler WM; Ghanem K; Golden M; Gorgos L; Hammerschlag M; Hollier L; Leone P; Marrazzo J; Mayer KH; Nyirjesy P; Rompalo A; Sanchez P; Stoner B; Wald A; Wendel G; Wiesenfeld HC; Cates W Jr; Holmes KK; Martin D; Handsfield H; McCormack W; Geisler WM; Adkinson NF; Andrews W; Augenbraun M; Batteiger B; Bolan G; Coles B; Deal C; Fortenberry JD; Hook E 3rd; Schwebke JR; Schulte J; Soper D; Stanberry L; Trigg B; Wimberly Y; Zenilman JM; Aaron K; Bachman L; Barclay L; Blythe MJ; Deal CD; Dimitrakov J; FitzGerald M; Fortenberry D; Hook EW 3rd; Jack N; Kerndt P; Marrazzo J; Ndowa FJ; Parkinson M; Piepert J; Reams P; Salhi B; Shea K; Soper D; Stoner B; Swann A; Tan L; Wong T; Workowski KA; Voigt R; Datta D; Dunne E; Hogben M; Holmberg S; Koumans E; Newman L; Aral SO; Ballard R; Branson B; Brooks J; Douglas J; Friedman A; Hu D; Kilmarx P; Papp J; Spradling P; Kelley B; Barner V; McElroy D
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4. Balakrishnan A, Wang L, Li X, Ohman-Strickland P, Malatesta P, Fan H: Inhibition of chlamydial infection in the genital tract of female mice by topical application of a peptide deformylase inhibitor. Microbiol Res; 2009;164(3):338-46
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  • On the basis of these data and our previous observations, we conclude that further evaluation of PDF inhibitors for prevention and treatment of sexually transmitted chlamydial infection is warranted.

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  • (PMID = 17936604.001).
  • [ISSN] 1618-0623
  • [Journal-full-title] Microbiological research
  • [ISO-abbreviation] Microbiol. Res.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI064441; United States / NIAID NIH HHS / AI / AI064441-02; United States / NIAID NIH HHS / AI / R21 AI064441-01; United States / NIAID NIH HHS / AI / R21 AI064441-02; United States / NIAID NIH HHS / AI / AI064441-01; United States / NIAID NIH HHS / AI / R33 AI071954; United States / NIAID NIH HHS / AI / R21 AI064441
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Dipeptides; 0 / Enzyme Inhibitors; 0 / N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide; EC 3.5.- / Amidohydrolases; EC 3.5.1.88 / peptide deformylase
  • [Other-IDs] NLM/ NIHMS123220; NLM/ PMC2735082
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5. Da Costa JB, Domingues D, Castro R, Exposto F: [Genital ulcers caused by sexually transmitted diseases: current therapies, diagnosis and their relevance in HIV pandemy]. Acta Med Port; 2006 Jul-Aug;19(4):335-42
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  • [Title] [Genital ulcers caused by sexually transmitted diseases: current therapies, diagnosis and their relevance in HIV pandemy].
  • The sexual transmitted pathogens associated with genital ulcers are Treponema pallidum, Haemophilus ducreyi, Calymmatobacterium granulomatis, Chlamydia trachomatis and Herpes simplex virus type 1 or 2.
  • The failure of the many different used guidelines in achieving a sustained reduction in the number of new cases, in particular the WHO syndromic management, leads into an over treatment of bacterial agents and missing of viral agents.
  • [MeSH-minor] Chancroid / complications. Chancroid / drug therapy. Female. Granuloma Inguinale / complications. Granuloma Inguinale / drug therapy. HIV Infections / complications. Herpes Genitalis / complications. Herpes Genitalis / drug therapy. Humans. Incidence. Lymphogranuloma Venereum / complications. Lymphogranuloma Venereum / drug therapy. Male. Portugal. Syphilis / complications. Syphilis / drug therapy

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  • (PMID = 17328851.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Portugal
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6. Pavlin NL, Parker RM, Piggin AK, Hopkins CA, Temple-Smith MJ, Fairley CK, Tomnay JE, Bowden FJ, Russell DB, Hocking JS, Pitts MK, Chen MY: Better than nothing? Patient-delivered partner therapy and partner notification for chlamydia: the views of Australian general practitioners. BMC Infect Dis; 2010;10:274
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  • [Title] Better than nothing? Patient-delivered partner therapy and partner notification for chlamydia: the views of Australian general practitioners.
  • Partner notification, testing and treatment are important facets of chlamydia control.
  • Patient-delivered partner therapy (PDPT) has been shown to improve the treatment of sexual partners.
  • In Australia, General Practitioners (GPs) are responsible for the bulk of chlamydia testing, diagnosis, treatment and follow up.
  • Barriers to GPs undertaking partner notification (provider referral) included: lack of time and staff; lack of contact details; uncertainty about the legality of contacting partners and whether this constitutes breach of patient confidentiality; and feeling both personally uncomfortable and inadequately trained to contact someone who is not their patient.
  • CONCLUSIONS: GPs reported some partners do not seek medical treatment even after they are notified of being a sexual contact of a patient with chlamydia.
  • [MeSH-major] Contact Tracing / methods. General Practitioners. Lymphogranuloma Venereum / drug therapy. Lymphogranuloma Venereum / epidemiology. Sexual Partners

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  • (PMID = 20849663.001).
  • [ISSN] 1471-2334
  • [Journal-full-title] BMC infectious diseases
  • [ISO-abbreviation] BMC Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2949762
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7. Ballard RC, Fehler HG, Htun Y, Radebe F, Jensen JS, Taylor-Robinson D: Coexistence of urethritis with genital ulcer disease in South Africa: influence on provision of syndromic management. Sex Transm Infect; 2002 Aug;78(4):274-7
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  • Ulcer inducing micro-organisms were detected either by a multiplex PCR assay, or in the case of lymphogranuloma venereum (LGV) serologically, and human immunodeficiency virus (HIV) infection was detected by an enzyme linked immunosorbent assay (ELISA) test.
  • RESULTS: Most (54%) of the ulcers were chancroidal, 18% were herpetic (HSV type 2), 6.5% primary syphilitic, and 3.2% due to LGV.
  • Nor was a particular ulcer associated with one type of urethritis more than the other.
  • This means treatment with long acting penicillin, combined with ciprofloxacin and azithromycin or erythromycin.
  • [MeSH-major] Anti-Bacterial Agents. Drug Therapy, Combination / therapeutic use. Genital Diseases, Male / complications. Ulcer / complications. Urethritis / complications
  • [MeSH-minor] Adult. Delivery of Health Care. Enzyme-Linked Immunosorbent Assay. Herpes Simplex / complications. Herpes Simplex / drug therapy. Humans. Lymphogranuloma Venereum / complications. Lymphogranuloma Venereum / drug therapy. Male. Mining. South Africa. Syphilis / complications. Syphilis / drug therapy. Transients and Migrants

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  • (PMID = 12181466.001).
  • [ISSN] 1368-4973
  • [Journal-full-title] Sexually transmitted infections
  • [ISO-abbreviation] Sex Transm Infect
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Other-IDs] NLM/ PMC1744505
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8. Spornraft-Ragaller P, Lück C, Straube E, Meurer M: [Lymphogranuloma venereum. Two cases from Dresden]. Hautarzt; 2006 Dec;57(12):1095-100
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  • [Title] [Lymphogranuloma venereum. Two cases from Dresden].
  • [Transliterated title] Lymphogranuloma venereum : Zwei Fälle aus Dresden.
  • Lymphogranuloma venereum (LGV) caused by Chlamydia trachomatis serovar L1-3 was formerly a rare sexually transmitted disease in western countries.
  • Treatment with doxycycline for 3-4 weeks was effective.
  • [MeSH-major] Doxycycline / therapeutic use. Lymphogranuloma Venereum / diagnosis. Lymphogranuloma Venereum / drug therapy
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Germany / epidemiology. Humans. Male. Middle Aged

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  • (PMID = 16421759.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; N12000U13O / Doxycycline
  • [Number-of-references] 18
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9. Méchaï F, de Barbeyrac B, Aoun O, Mérens A, Imbert P, Rapp C: Doxycycline failure in lymphogranuloma venereum. Sex Transm Infect; 2010 Aug;86(4):278-9
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  • [Title] Doxycycline failure in lymphogranuloma venereum.
  • Lymphogranuloma venereum (LGV) cases are currently re-emerging in the homosexual community, particularly in HIV-seropositive patients.
  • The standard treatment for this infection, which is caused by Chlamydia trachomatis L1, L2 and L3 serotypes, is a 3-week doxycycline regimen.
  • The case is reported of a male patient presenting with LGV, who was rapidly cured with moxifloxacin treatment after failure of extended treatment with cyclines.
  • Thus it may be a useful alternative when doxycycline treatment results in failure.
  • [MeSH-major] Anti-Infective Agents / therapeutic use. Aza Compounds / therapeutic use. Doxycycline / therapeutic use. Homosexuality, Male. Lymphogranuloma Venereum / drug therapy. Quinolines / therapeutic use
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Fluoroquinolones. Humans. Male. Proctitis / microbiology. Treatment Failure

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  • (PMID = 20660591.001).
  • [ISSN] 1472-3263
  • [Journal-full-title] Sexually transmitted infections
  • [ISO-abbreviation] Sex Transm Infect
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Infective Agents; 0 / Aza Compounds; 0 / Fluoroquinolones; 0 / Quinolines; N12000U13O / Doxycycline; U188XYD42P / moxifloxacin
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10. McLean CA, Stoner BP, Workowski KA: Treatment of lymphogranuloma venereum. Clin Infect Dis; 2007 Apr 1;44 Suppl 3:S147-52
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  • [Title] Treatment of lymphogranuloma venereum.
  • BACKGROUND: Lymphogranuloma venereum (LGV) classically presents with 1 or more genital ulcers or papules, as well as inguinal lymphadenopathy (buboes).
  • Recently reported cases of LGV proctitis in men who have sex with men, many of whom are coinfected with human immunodeficiency virus (HIV), have highlighted the importance of optimal clinical treatment of LGV.
  • METHODS: A review was conducted of the literature on LGV published between 1998 and 2004, as part of the development of the 2006 sexually transmitted disease treatment guidelines of the Centers for Disease Control and Prevention (CDC).
  • RESULTS: Doxycycline (100 mg orally twice daily for 21 days) remains the treatment of choice for LGV.
  • No controlled trials support the use of azithromycin or the use of alternative treatment regimens for persons with HIV infection.
  • CONCLUSIONS: On the basis of the present literature review, the CDC's treatment recommendations for LGV remain unchanged.
  • LGV clinical care, surveillance, and research are severely hindered by the lack of widely available, rapid, standardized tests for the diagnosis of LGV; therefore, patients with symptoms suggestive of LGV, including LGV proctitis, should be presumptively treated with antibacterial therapy for 3 weeks.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Doxycycline / therapeutic use. Lymphogranuloma Venereum / drug therapy

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  • (PMID = 17342667.001).
  • [ISSN] 1537-6591
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; N12000U13O / Doxycycline
  • [Number-of-references] 38
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11. Robertson A, Azariah S, Bromhead C, Tabrizi S, Blackmore T: Case report: lymphogranuloma venereum in New Zealand. Sex Health; 2008 Dec;5(4):369-70
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  • [Title] Case report: lymphogranuloma venereum in New Zealand.
  • We report New Zealand's first two cases of anorectal lymphogranuloma venereum (LGV).
  • [MeSH-major] Chlamydia trachomatis / isolation & purification. Lymphogranuloma Venereum / diagnosis. Lymphogranuloma Venereum / drug therapy. Rectal Diseases / diagnosis. Unsafe Sex
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Azithromycin / therapeutic use. Homosexuality, Male. Humans. Male. Middle Aged. New Zealand. Treatment Outcome

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  • (PMID = 19061558.001).
  • [ISSN] 1448-5028
  • [Journal-full-title] Sexual health
  • [ISO-abbreviation] Sex Health
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 83905-01-5 / Azithromycin
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12. de Vries HJ, Smelov V, Middelburg JG, Pleijster J, Speksnijder AG, Morré SA: Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment. Clin Infect Dis; 2009 Mar 1;48(5):e53-6
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  • [Title] Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment.
  • Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens.
  • These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis.
  • Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Chlamydia trachomatis / drug effects. Doxycycline / therapeutic use. Lymphogranuloma Venereum / drug therapy. Proctitis / drug therapy
  • [MeSH-minor] Anal Canal / microbiology. DNA, Bacterial / isolation & purification. Humans. Male. RNA, Bacterial / isolation & purification. Time Factors

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  • (PMID = 19191633.001).
  • [ISSN] 1537-6591
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / DNA, Bacterial; 0 / RNA, Bacterial; N12000U13O / Doxycycline
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13. Caumes E, Dupin N, Janier M, Chartier Ch, Viraben R, Bouscarat F, Section MST de la SFD: [Veneral lymphogranuloma (Nicolas-Favre disease)]. Ann Dermatol Venereol; 2006 Aug-Sep;133(8-9 Pt 2):2S33-2S34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Veneral lymphogranuloma (Nicolas-Favre disease)].
  • [MeSH-major] Lymphogranuloma Venereum / diagnosis. Lymphogranuloma Venereum / drug therapy

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  • (PMID = 17072170.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] France
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14. Den Hollander JG, Ossewaarde JM, de Marie S: Anorectal ulcer in HIV patients, don't forget lymphogranuloma venereum! AIDS; 2004 Jul 2;18(10):1484-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anorectal ulcer in HIV patients, don't forget lymphogranuloma venereum!
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. Lymphogranuloma Venereum / complications. Rectal Diseases / complications. Ulcer / complications
  • [MeSH-minor] Antiretroviral Therapy, Highly Active. HIV Infections / drug therapy. Humans. Male. Middle Aged


15. De Munain JL, Ezpeleta G, Imaz M, Del Mar Camara M, Esteban V, Santamaría JM, Cisterna R: Two lymphogranuloma venereum cases in a heterosexual couple in Bilbao (Spain). Sex Transm Dis; 2008 Nov;35(11):918-9
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  • [Title] Two lymphogranuloma venereum cases in a heterosexual couple in Bilbao (Spain).
  • [MeSH-major] Chlamydia trachomatis / isolation & purification. Heterosexuality. Lymphogranuloma Venereum / diagnosis. Sexually Transmitted Diseases, Bacterial / diagnosis
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Doxycycline / therapeutic use. Erythromycin / therapeutic use. Female. Humans. Male. Polymerase Chain Reaction. Pregnancy. Pregnancy Complications, Infectious / diagnosis. Pregnancy Complications, Infectious / drug therapy. Pregnancy Complications, Infectious / microbiology. Spain

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  • (PMID = 18641534.001).
  • [ISSN] 1537-4521
  • [Journal-full-title] Sexually transmitted diseases
  • [ISO-abbreviation] Sex Transm Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 63937KV33D / Erythromycin; N12000U13O / Doxycycline
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16. Velicko I, Cullberg M, Bratt G, Mamlöv G, Johnsson A, Hansson HB, Herrmann B, Blaxhult A: [Lymphogranuloma venereum--increased spread in Sweden. A rare Chlamydia subtype which become more and more common among men who have sex with men]. Lakartidningen; 2009 Jan 7-13;106(1-2):28-31
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  • [Title] [Lymphogranuloma venereum--increased spread in Sweden. A rare Chlamydia subtype which become more and more common among men who have sex with men].
  • [Transliterated title] Lymphogranuloma venereum--ökad spridning i Sverige. Sällsynt variant av klamydia som ökat bland män som har sex med män.
  • [MeSH-major] Homosexuality, Male. Lymphogranuloma Venereum / epidemiology
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. AIDS-Related Opportunistic Infections / diagnosis. AIDS-Related Opportunistic Infections / drug therapy. AIDS-Related Opportunistic Infections / microbiology. Anti-Bacterial Agents / administration & dosage. Communicable Disease Control. Diagnosis, Differential. Doxycycline / administration & dosage. Erythromycin / administration & dosage. Humans. Incidence. Male. Proctitis / diagnosis. Proctitis / microbiology. Sweden / epidemiology

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  • (PMID = 19235318.001).
  • [ISSN] 0023-7205
  • [Journal-full-title] Läkartidningen
  • [ISO-abbreviation] Lakartidningen
  • [Language] swe
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 63937KV33D / Erythromycin; N12000U13O / Doxycycline
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17. Shi LL, Lu JC, Huangfu YM: [Advances in the treatment of Chlamydia trachomatis infection]. Zhonghua Nan Ke Xue; 2005 Apr;11(4):296-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Advances in the treatment of Chlamydia trachomatis infection].
  • Chlamydia trachomatis may cause trachoma, pneumonia, urogenital infection, conjunctivitis and lymphogranuloma venereum, etc.
  • This paper reviews the effects of monotherapy, combined antibiotic regimens, and drug resistance during the treatment of Chlamydia trachomatis infection.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Chlamydia Infections / drug therapy. Chlamydia trachomatis
  • [MeSH-minor] Drug Resistance, Bacterial. Drug Therapy, Combination. Female. Humans. Male. Pregnancy

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  • (PMID = 15921264.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Number-of-references] 20
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18. Kaliaperumal K: Recent advances in management of genital ulcer disease and anogenital warts. Dermatol Ther; 2008 May-Jun;21(3):196-204
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Genital herpes, syphilis, lymphogranuloma venereum, granuloma venereum, or chancroid are the commonly encountered GUD.
  • The treatment modalities for these disorders have changed with advent and use of drugs such as azithromycin.
  • The treatment modalities differ in patients with HIV disease.
  • [MeSH-major] AIDS-Related Opportunistic Infections / drug therapy. Anti-Bacterial Agents / administration & dosage. Antiviral Agents / administration & dosage. Sexually Transmitted Diseases / drug therapy
  • [MeSH-minor] Condylomata Acuminata / diagnosis. Condylomata Acuminata / therapy. Guidelines as Topic. Humans. Papillomavirus Vaccines / administration & dosage

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  • (PMID = 18564250.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Antiviral Agents; 0 / Papillomavirus Vaccines
  • [Number-of-references] 53
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19. Rosen T, Vandergriff T, Harting M: Antibiotic use in sexually transmissible diseases. Dermatol Clin; 2009 Jan;27(1):49-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lymphogranuloma venereum, reemergent as a cause of proctitis, is treated with prolonged courses of doxycycline or minocycline.
  • Trimethoprim-sulfamethoxazole has replaced tetracycline derivatives as preferred treatment for donovanosis in many regions.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Sexually Transmitted Diseases, Bacterial / drug therapy

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  • (PMID = 18984368.001).
  • [ISSN] 1558-0520
  • [Journal-full-title] Dermatologic clinics
  • [ISO-abbreviation] Dermatol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Number-of-references] 84
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20. McMillan A, Kell P, Ward H, British Co-operative Clinical Group of British Association for Sexual Health and HIV: Diagnosing chlamydia and managing proctitis in men who have sex with men: current UK practice. Sex Transm Infect; 2008 Apr;84(2):97-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The questions concerned clinical practice regarding testing MSM for chlamydial infection at different anatomical sites, the clinical procedures used in the investigation of a MSM, the use of rectal smear microscopy, and the treatment used for rectal chlamydial infection.
  • Only 58 clinics (58%) used treatment regimens recommended for lymphogranuloma venereum in men with symptomatic chlamydial proctitis.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Chlamydia Infections / diagnosis. Homosexuality, Male / statistics & numerical data. Proctitis / drug therapy

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  • (PMID = 18077609.001).
  • [ISSN] 1472-3263
  • [Journal-full-title] Sexually transmitted infections
  • [ISO-abbreviation] Sex Transm Infect
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0601699
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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21. Moodley P, Sturm PD, Vanmali T, Wilkinson D, Connolly C, Sturm AW: Association between HIV-1 infection, the etiology of genital ulcer disease, and response to syndromic management. Sex Transm Dis; 2003 Mar;30(3):241-5
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  • GOAL: The goal was to determine the etiology and response to treatment of genital ulcer disease (GUD) in relation to HIV-1 infection.
  • RESULTS: Among the 587 recruited, the prevalences of infections due to HSV, Treponema pallidum, Chlamydia trachomatis (lymphogranuloma venereum [LGV]), Haemophilus ducreyi, Calymmatobacterium granulomatis, and HIV-1 were 48%, 14%, 11%, 10%, 1%, and 75%, respectively.
  • [MeSH-minor] Adolescent. Adult. Anti-Infective Agents / administration & dosage. Anti-Infective Agents / therapeutic use. Cohort Studies. Drug Therapy, Combination. Erythromycin / administration & dosage. Erythromycin / therapeutic use. Female. Humans. Logistic Models. Male. Middle Aged. Penicillins / administration & dosage. Penicillins / therapeutic use. Prevalence. Sexually Transmitted Diseases / epidemiology. Sexually Transmitted Diseases / etiology. South Africa / epidemiology. Surveys and Questionnaires. Syndrome

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  • (PMID = 12616144.001).
  • [ISSN] 0148-5717
  • [Journal-full-title] Sexually transmitted diseases
  • [ISO-abbreviation] Sex Transm Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Penicillins; 63937KV33D / Erythromycin
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22. Mårdh PA: Aetiology, diagnosis and therapy of sexually transmitted and allied infections--reflections on novel observations and current trends. Eur J Contracept Reprod Health Care; 2006 Sep;11(3):169-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aetiology, diagnosis and therapy of sexually transmitted and allied infections--reflections on novel observations and current trends.
  • The present communication highlights aspects on the aetiology, diagnosis and therapy of sexually transmitted infections (STIs) and some allied infections in which sexual transmission is regarded as possible.
  • Recent discoveries of novel aetiological agents of STIs, including mycoplasmas, may explain a lack of recovery from infections, due to the common use of antibiotic drugs to which these agents have a natural resistance.
  • The observation of a synergistic effect of a commonly used anti-inflammatory drug, which may overcome antifungal resistance in vulvovaginal candidiasis, will also be reviewed.
  • Furthermore, other reflections concern some of the classic STIs, e.g. lymphogranuloma verenerium, syphilis, gonorrhoea, herpes and condyloma.

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  • (PMID = 17056446.001).
  • [ISSN] 1362-5187
  • [Journal-full-title] The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • [ISO-abbreviation] Eur J Contracept Reprod Health Care
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 28
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23. Arshad AR: Kimura's disease of parotid gland presenting as solitary parotid swelling. Head Neck; 2003 Sep;25(9):754-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All the patients underwent surgical excision followed by initial high-dose steroid therapy and low-dose maintenance.
  • Treatment by surgical excision and steroid therapy has led to no recurrences.
  • It is a chronic inflammatory condition also called eosinophilic hyperplastic lymphogranuloma.
  • Treatment by surgical excision and steroid therapy has led to no recurrences.
  • [MeSH-major] Angiolymphoid Hyperplasia with Eosinophilia / drug therapy. Angiolymphoid Hyperplasia with Eosinophilia / surgery. Parotid Diseases / drug therapy. Parotid Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Edema / drug therapy. Edema / surgery. Humans. Male. Middle Aged. Steroids / therapeutic use. Treatment Outcome

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  • [Copyright] Copyright 2003 Wiley Periodicals, Inc. Head Neck 25: 754-757, 2003
  • (PMID = 12953311.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Steroids
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24. Draganov V, Nikolov R, Lazarov S: [Macrolides: pharmacology and clinical use]. Vutr Boles; 2000;32(4):13-7
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  • This review present mechanism of action, pharmacokinetic, adverse drug reactions and main clinical uses of the macrolides.
  • [MeSH-major] Anti-Bacterial Agents / pharmacology. Anti-Bacterial Agents / therapeutic use
  • [MeSH-minor] Endocarditis, Bacterial / drug therapy. Gram-Negative Bacteria / drug effects. Humans. Legionnaires' Disease / drug therapy. Lymphogranuloma Venereum / drug therapy. Macrolides. Periodontal Diseases / drug therapy. Pneumonia / drug therapy. Toxoplasmosis / drug therapy. Urethritis / drug therapy. Whooping Cough / drug therapy

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  • (PMID = 11688325.001).
  • [ISSN] 0506-2772
  • [Journal-full-title] Vŭtreshni bolesti
  • [ISO-abbreviation] Vutr Boles
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Bulgaria
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Macrolides
  • [Number-of-references] 10
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25. Trager JD: Sexually transmitted diseases causing genital lesions in adolescents. Adolesc Med Clin; 2004 Jun;15(2):323-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Chancroid / drug therapy. Chancroid / pathology. Female. Herpes Genitalis / drug therapy. Herpes Genitalis / pathology. Humans. Lymphogranuloma Venereum / drug therapy. Lymphogranuloma Venereum / pathology. Male. Molluscum Contagiosum / pathology. Molluscum Contagiosum / therapy. Scabies / pathology. Scabies / therapy. Syphilis / drug therapy. Syphilis / pathology

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  • (PMID = 15449848.001).
  • [ISSN] 1547-3368
  • [Journal-full-title] Adolescent medicine clinics
  • [ISO-abbreviation] Adolesc Med Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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26. Quint KD, Bom RJ, Bruisten SM, van Doorn LJ, Nassir Hajipour N, Melchers WJ, de Vries HJ, Morre SA, Quint WG: Comparison of three genotyping methods to identify Chlamydia trachomatis genotypes in positive men and women. Mol Cell Probes; 2010 Oct;24(5):266-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study was to evaluate the sensitivity and discriminatory power of three genotyping methods, respectively Omp1 sequencing, the Ct Detection and genoTyping (DT) assay and the pmpH real-time PCR discriminating an LGV infection from a non-LGV infection.
  • The Ct-DT assay detected 3 double Ct infections that caused a non interpretable result by Omp1 sequencing, while Omp1 sequencing has a higher discriminatory power that gave additional information about Ct genovariants.
  • Although the pmpH real-time PCR detected all LGV infections, a substantial amount (24%) of non-LGV infections were missed.
  • The sensitivity compared to AC2 Ct detection was 80% (95% CI 67-89%) for the Ct-DT assay, 72% (95% CI 58-83%) for Omp1 sequencing and 64% (95% CI 50-76%) for the pmpH real-time PCR.
  • In conclusion, the Ct-DT assay is appropriate for serovar distribution studies, epidemiological studies and differentiation between an LGV and non-LGV Ct infection, while Omp1 sequencing is more appropriate for phylogenetic studies.
  • The pmpH real-time PCR is suitable as second assay to differentiate between an LGV and non-LGV infection, but not as primary detection assay, due to its low sensitivity for non-LGV strains.
  • [MeSH-major] Bacterial Proteins / genetics. Chlamydia trachomatis / genetics. Lymphogranuloma Venereum / diagnosis. Molecular Typing / methods

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20457248.001).
  • [ISSN] 1096-1194
  • [Journal-full-title] Molecular and cellular probes
  • [ISO-abbreviation] Mol. Cell. Probes
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Outer Membrane Proteins; 0 / Bacterial Proteins; 0 / DNA Probes; 0 / DNA, Bacterial; 0 / PmpH protein, Chlamydia trachomatis; 0 / Porins; 146409-23-6 / omp1 protein, Chlamydia trachomatis
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27. Amankwah Y, Haefner H: Vulvar edema. Dermatol Clin; 2010 Oct;28(4):765-77
MedlinePlus Health Information. consumer health - Vulvar Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • At times, it is difficult to determine the cause of the vulvar edema.
  • Treatment consists of determining the origin of the edema and giving the appropriate therapy for that diagnosis as well as the use of compression and, at times, lymphatic massage.
  • [MeSH-minor] Candidiasis, Vulvovaginal / complications. Candidiasis, Vulvovaginal / drug therapy. Cellulitis / complications. Cellulitis / drug therapy. Chancroid / complications. Crohn Disease / complications. Crohn Disease / drug therapy. Dermatitis, Contact / complications. Dermatitis, Contact / drug therapy. Epstein-Barr Virus Infections / complications. Female. Filariasis / complications. Granuloma Inguinale / complications. Hematoma / complications. Herpesviridae Infections / complications. Herpesviridae Infections / drug therapy. Hidradenitis Suppurativa / complications. Hidradenitis Suppurativa / drug therapy. Humans. Iatrogenic Disease. Lymphogranuloma Venereum / complications. Lymphogranuloma Venereum / diagnosis. Lymphogranuloma Venereum / drug therapy. Parvoviridae Infections / complications. Pregnancy. Pregnancy Complications. Stevens-Johnson Syndrome / complications. Vulvar Neoplasms / complications

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20883919.001).
  • [ISSN] 1558-0520
  • [Journal-full-title] Dermatologic clinics
  • [ISO-abbreviation] Dermatol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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28. Dinas K, Zepiridis L, Arvanitidou O, Mavromatidis G, Nasioutziki M, Loufopoulos P, Daniilidis A, Mamopoulos A, Pantazis K, Dovas D, Theodoridis T, Loufopoulos A: Level of knowledge about genital chlamydial infection among Greek midwives and midwifery students. Scand J Infect Dis; 2010 Apr;42(4):249-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In contrast, the majority of both midwives and students were aware that when chlamydial infection is diagnosed in a woman, both she and her partner should receive treatment (90.7% vs 93.2%; p = 0.901).
  • [MeSH-major] Health Knowledge, Attitudes, Practice. Lymphogranuloma Venereum / epidemiology. Lymphogranuloma Venereum / transmission. Midwifery. Students
  • [MeSH-minor] Adolescent. Adult. Carrier State / drug therapy. Carrier State / epidemiology. Carrier State / transmission. Female. Greece. Humans. Middle Aged. Surveys and Questionnaires. Young Adult

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  • (PMID = 20085427.001).
  • [ISSN] 1651-1980
  • [Journal-full-title] Scandinavian journal of infectious diseases
  • [ISO-abbreviation] Scand. J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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29. Manavi K: A review on infection with Chlamydia trachomatis. Best Pract Res Clin Obstet Gynaecol; 2006 Dec;20(6):941-51
MedlinePlus Health Information. consumer health - Chlamydia Infections.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The advent of nucleic acid amplification tests and single-dose therapy for chlamydial infection has made home testing and easy treatment possible.
  • [MeSH-minor] Adolescent. Adult. Anti-Bacterial Agents / therapeutic use. Anti-Infective Agents / therapeutic use. Conjunctival Diseases / etiology. Contact Tracing. Female. Genital Diseases, Male / etiology. Great Britain / epidemiology. Humans. Lymphogranuloma Venereum / drug therapy. Lymphogranuloma Venereum / etiology. Macrolides / therapeutic use. Male. Mass Screening / methods. Pelvic Inflammatory Disease / diagnosis. Pelvic Inflammatory Disease / drug therapy. Pelvic Inflammatory Disease / etiology. Penicillins / therapeutic use. Quinolones / therapeutic use. Tetracyclines / therapeutic use

  • Genetic Alliance. consumer health - Chlamydia.
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  • (PMID = 16934531.001).
  • [ISSN] 1521-6934
  • [Journal-full-title] Best practice & research. Clinical obstetrics & gynaecology
  • [ISO-abbreviation] Best Pract Res Clin Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Infective Agents; 0 / Macrolides; 0 / Penicillins; 0 / Quinolones; 0 / Tetracyclines
  • [Number-of-references] 36
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30. Roest RW, van der Meijden WI, European Branch of the International Union against Sexually Transmitted Infection and the European Office of the World Health Organization: European guideline for the management of tropical genito-ulcerative diseases. Int J STD AIDS; 2001 Oct;12 Suppl 3:78-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Chancroid / diagnosis. Chancroid / drug therapy. Chancroid / prevention & control. Europe. Granuloma Inguinale / diagnosis. Granuloma Inguinale / drug therapy. Granuloma Inguinale / prevention & control. Humans. Lymphogranuloma Venereum / diagnosis. Lymphogranuloma Venereum / drug therapy. Lymphogranuloma Venereum / prevention & control. Macrolides. Skin Ulcer / prevention & control

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  • (PMID = 11589803.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Guideline; Journal Article; Practice Guideline
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Macrolides
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31. Regnath T, Tewald F, Enders M, Hassler D: [Sexually transmitted infections caused by Chlamydia]. Dtsch Med Wochenschr; 2006 Dec 8;131(49):2761-2
Hazardous Substances Data Bank. DOXYCYCLINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Conjunctivitis, Inclusion / drug therapy. Conjunctivitis, Inclusion / epidemiology. Conjunctivitis, Inclusion / pathology. Conjunctivitis, Inclusion / transmission. Doxycycline / therapeutic use. Female. Germany / epidemiology. Humans. Infertility, Female / etiology. Lymphogranuloma Venereum / drug therapy. Lymphogranuloma Venereum / epidemiology. Lymphogranuloma Venereum / pathology. Lymphogranuloma Venereum / transmission. Male. Prevalence. Risk Factors. Sexually Transmitted Diseases, Bacterial / drug therapy. Sexually Transmitted Diseases, Bacterial / epidemiology. Sexually Transmitted Diseases, Bacterial / pathology. Sexually Transmitted Diseases, Bacterial / transmission

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  • MedlinePlus Health Information. consumer health - Chlamydia Infections.
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  • (PMID = 17211935.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; N12000U13O / Doxycycline
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