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Items 1 to 27 of about 27
1. Benhaddou R, Sayouti A, Khoumiri R, Guelzim H, Gaboune L, Benfdil N, Moutaouakil A, Benhaddou A, Essadki O, Ousehal A: [Iris metastasis from lung cancer]. J Fr Ophtalmol; 2008 Apr;31(4):427-9
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  • [Title] [Iris metastasis from lung cancer].
  • A 47-year-old man with a history of lung adenocarcinoma presented a red and painful right eye with loss of visual acuity after the 5th course of chemotherapy.
  • The ophthalmologic exam showed visual acuity at 3/10 and diffuse iris nodular lesions in the same eye.
  • The ocular scan showed iris tumors without choroidal metastasis.
  • [MeSH-major] Adenocarcinoma / secondary. Iris Neoplasms / secondary. Lung Neoplasms / pathology

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  • (PMID = 18563045.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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2. Goto T, Maeshima A, Oyamada Y, Kato R: Solitary pulmonary metastasis from prostate sarcomatoid cancer. World J Surg Oncol; 2010;8:101
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  • [Title] Solitary pulmonary metastasis from prostate sarcomatoid cancer.
  • BACKGROUND: Pulmonary metastasis from prostate cancer is considered to be a late event, and patients can be treated with chemotherapy or hormonal manipulation.
  • However, there has been only a few reports on surgical resection for pulmonary metastasis from prostate cancer.
  • CASE PRESENTATION: We present a surgical case of solitary pulmonary metastasis from prostate cancer.
  • During postoperative follow-up, chest computed tomography showed a nodular shadow in the lung, and thoracoscopic wedge resection of the lung was performed.
  • This is the first reported case of solitary pulmonary metastasis from prostate sarcomatoid cancer.
  • CONCLUSION: Isolated pulmonary metastasis from prostate sarcomatoid cancer is extremely rare, but surgery could be the treatment of choice.
  • [MeSH-major] Carcinosarcoma / secondary. Lung Neoplasms / secondary. Pneumonectomy / methods. Prostatic Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Positron-Emission Tomography. Prostatectomy. Tomography, X-Ray Computed

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  • [Cites] Cancer. 1984 Dec 15;54(12):3078-84 [6498785.001]
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  • (PMID = 21092117.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2995788
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3. Chen W, Shih CS, Wang YT, Tseng GC, Hsu WH: Angiosarcoma with pulmonary metastasis presenting with spontaneous bilateral pneumothorax in an elderly man. J Formos Med Assoc; 2006 Mar;105(3):238-41
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  • [Title] Angiosarcoma with pulmonary metastasis presenting with spontaneous bilateral pneumothorax in an elderly man.
  • It is frequently accompanied by thin-walled cavitary pulmonary metastasis, and is often obscure on chest radiograph.
  • We report a case of angiosarcoma of the scalp with cystic metastasis to the lung in a 63-year-old man, presenting as recurrent bilateral spontaneous pneumothorax.
  • Lung metastasis was missed at the first episode of pneumothorax because the lung-expanded chest radiograph showed no significant abnormality.
  • Two months later, bilateral pneumothorax recurred, and high-resolution computed tomography revealed multiple cystic, cavitary and nodular lesions.
  • Pulmonary metastasis was confirmed by video-assisted thoracoscopic surgery, and pleurodesis was performed.
  • After the operation, the patient received chemotherapy; no recurrence of pneumothorax was found during 6 months of follow-up.
  • Pneumothorax in the elderly should be differentiated from malignant metastatic lung tumors.

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  • (PMID = 16520841.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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4. Matsuda H, Chida K, Hashimoto D, Naito T, Fujisawa T, Enomoto N, Miwa S, Nakano H, Suzuki K, Yokomura K, Ide K, Suda T, Nakamura H: [A case of adenocarcinoma of the lung presenting symptoms of choroidal metastasis as the initial clinical manifestation]. Nihon Kokyuki Gakkai Zasshi; 2004 May;42(5):410-4
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  • [Title] [A case of adenocarcinoma of the lung presenting symptoms of choroidal metastasis as the initial clinical manifestation].
  • High-resolution CT showed a nodular shadow in the left lower lobe.
  • We concluded that the choroidal tumors had metastasized from the lung.
  • Combined chemotherapy (CDDP + CPT-11) followed by irradiation of both eyes and brain were performed.
  • It is important to notice ophthalmologic symptoms because lung cancer may metastasize to the choroids.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Choroid Neoplasms / secondary. Lung Neoplasms / diagnosis. Vision Disorders / etiology
  • [MeSH-minor] Female. Fluorescein Angiography. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 15168458.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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5. Ihara N, Yashiro N, Kinoshita T, Yoshigi J, Ouchi T, Narita M, Hattori C, Kaneko N: Diffuse intrasinusoidal liver metastasis of small cell lung cancer causing fulminant hepatic failure: CT findings-a case report. Radiat Med; 2001 Sep-Oct;19(5):275-7
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  • [Title] Diffuse intrasinusoidal liver metastasis of small cell lung cancer causing fulminant hepatic failure: CT findings-a case report.
  • A 65-year-old man with small cell lung cancer treated with two courses of chemotherapy manifested appetite loss and abdominal distention 10 days before admission.
  • Helical CT scanning of the abdomen and pelvis disclosed marked hepatomegaly without any visible nodular lesion in the hepatic parenchyma.
  • [MeSH-major] Carcinoma, Small Cell / secondary. Liver Failure / etiology. Liver Neoplasms / secondary. Lung Neoplasms / pathology. Tomography, X-Ray Computed


6. Sairenji T, Fujii Y, Eriguchi M: [A case of advanced gastric cancer with lung and liver metastasis responding remarkably to combination chemotherapy with CDDP and CPT-11]. Gan To Kagaku Ryoho; 2000 Jan;27(1):103-6
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  • [Title] [A case of advanced gastric cancer with lung and liver metastasis responding remarkably to combination chemotherapy with CDDP and CPT-11].
  • Several examinations showed massive lung and liver metastases from Type-I gastric cancer beneath the esophagogastric mucosal junction.
  • We then tried combination chemotherapy of CPT-11 40 mg/day a day with CDDP 15 mg/day for 4 days.
  • The primary stomach lesion was reduced and was visible as a small nodular flat mass.
  • Moreover, we found that the lung and liver metastatic lesions were already reduced.
  • Three months have passed since CDDP-CPT-11 combination therapy, and we have not found any recurrent tumors so far.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology
  • [MeSH-minor] Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage. Drug Administration Schedule. Humans. Infusions, Intravenous. Male. Middle Aged


7. Kobayashi S, Nakajima T, Iizasa T, Tsujimura H, Itami M, Kimura H: Pulmonary metastasis with endobronchial spread from sinonasal melanoma during a 9-year follow-up. Intern Med; 2010;49(8):777-9
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  • [Title] Pulmonary metastasis with endobronchial spread from sinonasal melanoma during a 9-year follow-up.
  • A 60-year-old woman was diagnosed with pulmonary metastasis with endobronchial spread of sinonasal melanoma 9 years after the initial treatment.
  • She had originally been diagnosed with sinonasal malignant melanoma and received chemotherapy combined with carbon ion radiotherapy.
  • During routine follow-up, chest CT showed a nodular lesion on the left upper lung lobe.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / secondary. Lung Neoplasms / diagnosis. Melanoma / diagnosis. Melanoma / secondary. Nose Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Female. Follow-Up Studies. Humans. Middle Aged

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  • (PMID = 20424370.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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8. Hirai K, Sano H, Kita K, Mikata K, Ueki T, Fujikawa N, Kitami K, Hirokawa S: [Small cell carcinoma of the bladder: a case report]. Hinyokika Kiyo; 2005 Sep;51(9):635-8
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  • Ultrasonography, magnetic resonance imaging and cystoscopy revealed a nodular invasive tumor in urinary bladder.
  • Total cystectomy with ileal conduit was performed following 1 course of neoadjuvant chemotherapy (M-VAC).
  • Computed tomography (CT) before adjuvant chemotherapy revealed tiny lung metastasis in left peripheral lung area.
  • As postoperative adjuvant therapy, 4 courses of chemotherapy (etoposide and calboplatin) were performed with 50 Gy of extra beam radiotherapy to the lung metastasis.
  • Follow up CT revealed disapperance of lung metastasis, and the patient has been free from disease for one year after chemotherapy.
  • [MeSH-major] Carcinoma, Small Cell / secondary. Carcinoma, Transitional Cell / secondary. Cystectomy. Lung Neoplasms / secondary. Neoplasms, Multiple Primary. Urinary Bladder Neoplasms / pathology. Urinary Diversion
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Etoposide / administration & dosage. Humans. Male. Middle Aged

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  • (PMID = 16229379.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
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9. Hatori M, Ohtani H, Yamada N, Uzuki M, Kokubun S: Synchronous multifocal osteosarcoma with lymphatic spread in the lung: an autopsy case report. Jpn J Clin Oncol; 2001 Nov;31(11):562-6
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  • [Title] Synchronous multifocal osteosarcoma with lymphatic spread in the lung: an autopsy case report.
  • Radiological examinations showed multiple sclerotic lesions in the left distal femur and in the ipsilateral proximal tibia without pulmonary metastasis at the first examination.
  • Histological examination showed osteoblastic-type osteosarcoma.
  • Despite high-dose chemotherapy the patient died of multiple bone and lung involvements 6 months after the initial diagnosis.
  • Autopsy examination revealed prominent invasion of the tumor cells into lymphatic vessels and pleural dissemination without the formation of bulky, nodular metastasis in the lungs.
  • Metastases in pulmonary hilar lymph nodes were noted without metastasis in other organs.
  • [MeSH-major] Bone Neoplasms / pathology. Lung Neoplasms / secondary. Lymphatic Vessel Tumors / secondary. Neoplasms, Multiple Primary / pathology. Osteosarcoma / secondary
  • [MeSH-minor] Adolescent. Femur. Humans. Lymphatic Metastasis. Male. Multiple Sclerosis / pathology


10. Minami S, Komuta K, Asai M: [A case of amylase-producing lung cancer]. Nihon Kokyuki Gakkai Zasshi; 2003 Oct;41(10):717-21
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  • [Title] [A case of amylase-producing lung cancer].
  • Chest CT revealed a nodular lesion in the right S6 and swollen right hilar lymph nodes.
  • Amylase isozyme patterns identified the salivary types.
  • The pancreas and salivary glands were unlikely to have any clinical involvement in the hyperamylasemia, but lung cancer with subcutaneous metastasis was strongly suspected clinically as the source.
  • Chemotherapy failed to prevent tumor progression and the patient eventually died of respiratory failure.
  • Immunohistological examination of the subcutaneous lesion showed positive staining for salivary-type amylase, whereas that of the lung primary lesion disclosed small cell carcinoma and negative staining for amylase.
  • In most cases, amylase-producing lung cancers have been diagnosed as adenocarcinoma.
  • [MeSH-major] Amylases / biosynthesis. Carcinoma, Small Cell / enzymology. Lung Neoplasms / enzymology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Fatal Outcome. Humans. Isoenzymes / analysis. Isoenzymes / biosynthesis. Male. Neoplasms, Connective Tissue / secondary. Subcutaneous Tissue

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  • (PMID = 14584392.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; EC 3.2.1.- / Amylases
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11. Imaizumi M, Takeuchi M, Seki Y, Yoshioka H, Yamada K: [An successful case of combined daily oral administration of UFT and low-dose etoposide for multiple metastases of lung cancer]. Gan To Kagaku Ryoho; 2000 Jul;27(7):1035-8
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  • [Title] [An successful case of combined daily oral administration of UFT and low-dose etoposide for multiple metastases of lung cancer].
  • The authors treated a 49-year old female patient, who had multiple metastases of lung cancer, by combined daily oral administration of UFT and low-dose ETP.
  • She was admitted to our hospital due to complaints of cough and dyspnea, and multiple nodular shadows were seen in both lungs on chest X-rays.
  • The pulmonary lesion was diagnosed as pulmonary metastasis of lung cancer (squamous cell car) by lung biopsy under CT-guide.
  • She also had bone metastasis of the ribs and cerebellar metastasis from the lung cancer.
  • Combination chemotherapy of UFT 300 mg/body daily and etoposide 25 mg/body daily was performed for 13 months.
  • Combined daily oral administration of UFT and low-dose etoposide is considered to be safe and effective, and the treatment useful for recovering QOL in advanced lung cancer patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Lung Neoplasms / drug therapy
  • [MeSH-minor] Administration, Oral. Drug Administration Schedule. Etoposide / administration & dosage. Female. Humans. Middle Aged. Neoplasms, Multiple Primary / drug therapy. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 10925690.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 6PLQ3CP4P3 / Etoposide; 1-UFT protocol
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12. Ishiyama T, Aoyama T, Hirahara H, Iwashima A, Tsukada H, Souma T: [Successful resection of endotracheal metastatic lung cancer using percutaneous cardiopulmonary support system: a case report]. Kyobu Geka; 2001 Jan;54(1):19-23
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  • [Title] [Successful resection of endotracheal metastatic lung cancer using percutaneous cardiopulmonary support system: a case report].
  • We experienced a rare case of endotracheal metastasis derived from squamous cell lung cancer.
  • The patient was 56 year-old male whose primary lung cancer of the left upper lobe was completely resected.
  • Pathological diagnosis indicated stage IIB and he underwent two cycles of chemotherapy with CDDP + VDS.
  • He had been asymptomatic thereafter, however, two years postoperative chest CT revealed a nodular lesion of the anterior carinal wall.
  • Majority of the reported cases of endotracheal metastases were treated conservatively as radiation, laser and/or chemotherapy.
  • [MeSH-minor] Humans. Lung Neoplasms / pathology. Male. Middle Aged. Reconstructive Surgical Procedures. Treatment Outcome

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  • (PMID = 11197904.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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13. Lim YJ, Kim JH, Oh SH, Jeon SC, Koh HC, Lee YH: Pulmonary toxocariasis masquerading as metastatic tumor nodules in a child with osteosarcoma. Pediatr Blood Cancer; 2009 Dec 15;53(7):1343-5
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  • A 14-year-old male, who completed chemotherapy following limb salvage surgery for osteosarcoma approximately 2 years ago, was seen for routine follow-up.
  • A CT scan revealed new scattered multifocal nodular lesions.
  • An ultrasonography-guided percutaneous needle biopsy was done to confirm pulmonary metastasis of the underlying osteosarcoma.
  • The lung biopsy showed findings of eosinophilic pneumonia with no evidence of malignancy.
  • [MeSH-major] Larva Migrans, Visceral / diagnosis. Lung Diseases, Parasitic / diagnosis. Lung Neoplasms / diagnosis. Osteosarcoma / diagnosis. Pulmonary Eosinophilia / diagnosis
  • [MeSH-minor] Adolescent. Animals. Antibodies, Helminth / blood. Antineoplastic Combined Chemotherapy Protocols. Bone Neoplasms / drug therapy. Bone Neoplasms / surgery. Cattle / parasitology. Cattle Diseases / parasitology. Cisplatin / administration & dosage. Diagnosis, Differential. Doxorubicin / administration & dosage. Food Parasitology. Humans. Humerus. Immunoglobulin G / blood. Liver / parasitology. Male. Meat / adverse effects. Meat / parasitology. Methotrexate / administration & dosage. Toxocariasis / transmission

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19637318.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Helminth; 0 / Immunoglobulin G; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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14. Seo JB, Im JG, Goo JM, Chung MJ, Kim MY: Atypical pulmonary metastases: spectrum of radiologic findings. Radiographics; 2001 Mar-Apr;21(2):403-17
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  • Typical radiologic findings of a pulmonary metastasis include multiple round variable-sized nodules and diffuse thickening of interstitium.
  • A detailed knowledge of the atypical radiologic features of a pulmonary metastasis with a good understanding of the histopathologic background is essential for correct diagnosis.
  • Squamous cell carcinoma is regarded as the most common cell type of a cavitating metastasis, but metastatic nodules from adenocarcinomas and sarcomas also cavitate occasionally.
  • Peritumoral hemorrhage results in areas of nodular attenuation surrounded by a halo of ground-glass opacity.
  • Even though tumor emboli in pulmonary arteries can be seen at computed tomography, diagnosis is difficult because they are located in small or medium arteries.
  • A common radiologic appearance of an endobronchial metastasis is an atelectasis.
  • In cases of an endobronchial or a solitary pulmonary metastasis, differentiation between bronchogenic carcinoma and metastasis is difficult.
  • A sterilized metastasis after chemotherapy is radiologically indistinguishable from a residual viable tumor.
  • Benign tumors such as uterine leiomyomas and giant cell tumors of the bone rarely metastasize to the lung.
  • [MeSH-major] Lung Neoplasms / secondary. Tomography, X-Ray Computed
  • [MeSH-minor] Calcinosis / pathology. Calcinosis / radiography. Diagnosis, Differential. Humans. Lung / pathology. Lung / radiography. Pneumothorax / pathology. Pneumothorax / radiography

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  • (PMID = 11259704.001).
  • [ISSN] 0271-5333
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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15. Tas F, Kurul S, Camlica H, Topuz E: Malignant melanoma in Turkey: a single institution's experience on 475 cases. Jpn J Clin Oncol; 2006 Dec;36(12):794-9
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  • RESULTS: Of the 475 adult cases with complete staging procedure, the incidence of localized (stages I-II) disease was 301 (63.4%), and followed by node involved (stage III) and metastatic (stage IV) disease with the incidence of 117 (24.6%) and 57 (12.0%), respectively.
  • The superficial spreading type was the commonest histology (52.2%).
  • In metastatic patients, two thirds had distant metastases including lung metastases and half of them had single metastatic region.
  • Nodular histology subtype, deeper Breslow tumor depth, extensive invasion, presence of ulceration, advanced stage, presence of relapse, being male and elderly patient, presence of visceral recurrence, and high mitotic activity were found to be associated with poor prognosis for overall survival in localized disease.
  • Unresponsiveness to chemotherapy, visceral metastasis, multiple metastases and not given chemotherapy were the poor prognostic factors for overall survival.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age of Onset. Aged. Aged, 80 and over. Female. Humans. Incidence. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Survival Rate. Turkey / epidemiology

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  • (PMID = 17060409.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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16. Busnardo B, Daniele O, Pelizzo MR, Mazzarotto R, Nacamulli D, Devido D, Mian C, Girelli ME: A multimodality therapeutic approach in anaplastic thyroid carcinoma: study on 39 patients. J Endocrinol Invest; 2000 Dec;23(11):755-61
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  • [Title] A multimodality therapeutic approach in anaplastic thyroid carcinoma: study on 39 patients.
  • The aim of this study was to investigate the role of multimodality treatment in patients with anaplastic thyroid carcinoma.
  • About one-third of patients had a history of preceeding nodular goiter.
  • Local disease was present in 26 patients while distant metastases, mainly to the lung, were present in 22 at diagnosis or quickly developed during the observation period in all the others except one.
  • Thirty-two patients were previously untreated: 9 of them were in good general condition, 1 had limited lung metastases, and the tumor mass was considered resectable by the surgeon.
  • These 9 patients were treated with cisplatin once a week and radiotherapy (RT) 36Gy in 18 fractions over three weeks, followed by total thyroidectomy (TT) and by further chemotherapy (CHT) with adriamycin and bleomycin in 4 patients.
  • Seven patients, 3 with lung metastases at diagnosis, had undergone TT, followed by RT in 5, in another hospital and were subsequently referred to our center due to the presence of distant metastases.
  • Nine patients with distant metastases at diagnosis (Group 2) received CHT; one of them had a disappearance of lung metastases and was then treated by TT and further CHT.
  • Group 3 consisted of 14 elderly patients in poor general conditions; 4 of these received local RT, while the remaining did not receive any treatment.
  • The patient from Group 2 who was treated in a second time by TT is alive without disease after 60 months.
  • In some patients multimodality treatment (TT, RT and CHT) is associated with increased survival.
  • Nine out of 16 patients, who underwent surgery and complementary treatment, had no local progression.
  • In all but one distant metastases developed, mainly in the lung, during or after post-surgical CHT.
  • Only a few patients responded to CHT, confirming that anaplastic thyroid carcinoma is often resistant to anticancer drugs.
  • [MeSH-major] Carcinoma / therapy. Combined Modality Therapy. Thyroid Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Disease-Free Survival. Doxorubicin / administration & dosage. Female. Humans. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Radiotherapy. Survival Rate. Thyroidectomy

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  • (PMID = 11194710.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin
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17. Karnak I, Emin Senocak M, Kutluk T, Tanyel FC, Büyükpamukçu N: Pulmonary metastases in children: an analysis of surgical spectrum. Eur J Pediatr Surg; 2002 Jun;12(3):151-8
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  • Pulmonary surgery is frequently used for the treatment of metastasis or nodules in children with various types of malignancies.
  • Eighteen children consisting of 11 boys and 7 girls (age range, 3 to 18 years) underwent thoracotomy for pulmonary metastasis excision.
  • Pulmonary metastases were encountered either at the time of initial diagnosis (22 %) or occurred within 6 months to 5 years.
  • They were frequently nodular (94 %), unilateral (94 %) and located in the right lung (70 %).
  • The nodules contained tumour cells in most cases (n = 14) (78 %), mature nephrogenic elements (6 %) and no tumour tissue (16 %) in the remaining cases.
  • However, synovial sarcoma was encountered in metastasis in one case with fibrosarcoma primary.
  • Therefore combined therapies such as chemotherapy and/or radiotherapy should be continued in the postoperative period.
  • [MeSH-major] Lung Neoplasms / secondary. Lung Neoplasms / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Pneumonectomy. Retrospective Studies. Thoracotomy. Time Factors. Treatment Outcome

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  • (PMID = 12101495.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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18. Kanoh T, Iino Y, Horiguchi J, Takei H, Maemura M, Yokoe T, Morishita Y: A case report of advanced male breast cancer with an objective response to tamoxifen treatment. Breast Cancer; 2000;7(3):256-60
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  • [Title] A case report of advanced male breast cancer with an objective response to tamoxifen treatment.
  • Chest X-ray and CT showed massive pleural effusion and multiple small nodular lesions in the lung.
  • Invasive ductal carcinoma of the breast was diagnosed by incisional biopsy,confirming advanced breast cancer with lung metastases and bilateral pleural effusion(T4cN2M1, Stage IV).
  • Because ER and PgR levels were 110 fmol/mg and 190 fmol/mg, respectively, and because his general condition was poor, we selected medical treatment with tamoxifen(TAM).
  • The patient underwent local excision of the scar tissue.
  • The tumor in the chest wall recurred two months after the end of TAM treatment, possibly because the patient did not accept continuous TAM therapy.
  • The patient died from complications of brain metastasis 32 months after the start of TAM treatment.
  • We report a rare case of advanced male breast cancer and on the effectiveness of continuous TAM treatment.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Brain Neoplasms / secondary. Breast Neoplasms, Male / drug therapy. Breast Neoplasms, Male / pathology. Carcinoma, Ductal, Breast / secondary. Lung Neoplasms / secondary. Tamoxifen / therapeutic use
  • [MeSH-minor] Aged. Biopsy. Fatal Outcome. Humans. Male. Neoplasm Staging. Quality of Life. Tomography, X-Ray Computed. Treatment Outcome


19. Hori J, Kato Y, Iwata T, Taniguchi N, Hashimoto H, Yachiku S: [A case of penile malignant melanoma]. Hinyokika Kiyo; 2003 Aug;49(8):493-6
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  • Cystoscopy and urethrography revealed urethral invasion of malignant melanoma, and magnetic resonance imaging (MRI) of the penis revealed invasion to prostate, and pelvic lymph node metastases in abdominal compuled tomography (CT) but no organ metastases.
  • The pathological findings were nodular malignant melanoma, pT4bN2bM1a, and the surgical margin was positive.
  • After these therapies, chemotherapy was performed.
  • Five months later, CT revealed multiple lung and brain metastases, and radiation therapy and chemotherapy were performed.
  • [MeSH-minor] Aged. Combined Modality Therapy. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Prostatic Neoplasms / pathology

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  • (PMID = 14518390.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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20. Vescini F, Di Gaetano P, Vigna E, Pascoli A, Cacciari M: Anaplastic thyroid carcinoma in a 49 year-old woman with a long-standing goiter. A case report. Minerva Endocrinol; 2000 Sep-Dec;25(3-4):81-3
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  • A 49 year-old woman with anaplastic thyroid carcinoma came, for the first time, to our clinic with an enlarged supraclavicular lymph node.
  • Ten years earlier she received a diagnosis of benign nodular goiter and has been followed up with ultrasonography, which never demonstrated any enlargement of her thyroid nodule and with fine needle aspiration biopsies (FNAB), that always proved normal.
  • The histological examination reported a thyroid anaplastic carcinoma, composed of osteoclast-like cells and large calcifications, which showed signs of local invasion and vessel infiltration; the supraclavicular lymph node proved to be a large metastasis of anaplastic thyroid cancer.
  • Total body CT scan, bone scintigraphy and brain CT scan showed, respectively, lung, bone and brain metastasis.
  • Postoperative chemotherapy was rapidly interrupted for acute toxicity.
  • The patient died for lung, bone and brain metastasis, 2 months after initial examination.

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  • (PMID = 11338400.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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21. Límanová Z, Jiskra J: [Thyroid diseases in oncological patients]. Cas Lek Cesk; 2005;144(8):524-8
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  • In case of unknown origin of metastasis and nodular goitre the ultrasound examination with fine needle aspiration biopsy confirms or excludes the thyroid origin.
  • If oncological patients prove to have a thyroid functional failure the endocrinologist must correct the function as fast as possible to enable oncological treatment.
  • There is no evidence that chemotherapy can influence the thyroid function, but radiotherapy can cause thyroiditis with later hypofunction.
  • The interferon therapy causes thyroid dysfunction in 10% of patients and the recommendation to examine not only TSH and FT4 but also thyroid antibodies is warranted.
  • In case of renal tumor (Grawitz), breast or lung carcinoma the thyroid can be attacked with metastasis, and ultrasound with fine needle biopsy can reliably differentiate between primary or secondary thyroid involvements.

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  • (PMID = 16173605.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 31
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22. Singhal M, Raina V, Gupta R, Das P: T cell-prolymphocytic leukemia detected in a patient of breast cancer at the time of recurrence: a case report. Cases J; 2010;3:4
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  • [Title] T cell-prolymphocytic leukemia detected in a patient of breast cancer at the time of recurrence: a case report.
  • INTRODUCTION: Therapy related second malignancy of the hematological system is small but real risk after adjuvant chemotherapy for breast cancer.
  • It includes acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS); however T-cell prolymphocytic leukemia (T-PLL) has not been described earlier in relation to breast cancer and its therapy.
  • Histophotomicrograph of the excised breast lesion showed a 2.1 cm duct carcinoma, positive for ER and PR with 1 out of 25 lymph nodes positive for metastasis.
  • She received 6 cycles of chemotherapy with cyclophosphamide, epirubicin, and 5-fluorouracil.
  • Contrast-enhanced computed tomography of the chest and abdomen was done which revealed an anterior mediastinal mass with destruction of sternum along with multiple small nodular shadows in bilateral lung fields suggestive of lung metastasis.
  • She was started on chemotherapy for T-PLL along with hormonal therapy with aromatase inhibitor.
  • CONCLUSION: Our case describes the potential of breast chemotherapy to cause grave second hematological malignancies of the T-cell lymphoid lineage, not described earlier.
  • Such events highlight the importance to identify those patients of breast cancer in whom chemotherapy can safely be avoided.

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  • (PMID = 20076807.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2806858
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23. Cöl C: Immature teratoma in both mediastinum and liver of a 21-Year-old female patient. Acta Med Austriaca; 2003;30(1):26-8
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  • Computed tomography (CT) also showed a big mass which contained multiple high density, nodular, semi-solid, heterogenic structures in the liver and another mass which contained multiple low density cystic lesions in the anterior mediastinum.
  • The mediastinal tumour extended to the diaphragm on the right side, and is dissected from the 'surrounding lung, pericardium' and excised from diaphragm.
  • Chemotherapy was given after surgery.
  • The patient tolerated the procedure well and her postoperative course was unremarkable.
  • At the first follow up 4 months after surgery she was alive and well and there was no evidence of recurrence, but the patient died within seven months with hepatic recurrence and spreading metastasis.
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Biopsy, Needle. Combined Modality Therapy. Female. Humans. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 12558563.001).
  • [ISSN] 0303-8173
  • [Journal-full-title] Acta medica Austriaca
  • [ISO-abbreviation] Acta Med. Austriaca
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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24. Kovatcheva RD, Hadjieva TD, Kirilov GG, Lozanov BS: Recombinant human TSH in radioiodine treatment of differentiated thyroid cancer. Nucl Med Rev Cent East Eur; 2004;7(1):13-9
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  • [Title] Recombinant human TSH in radioiodine treatment of differentiated thyroid cancer.
  • BACKGROUND: Recombinant human TSH (rhTSH) has been developed to facilitate the follow-up for persistent or recurrent differentiated thyroid cancer (DTC), avoiding the hypothyroid symptoms after the withdrawal of Levothyroxine (L-T4) suppressive therapy.
  • MATERIAL AND METHODS: To analyse the effect of rhTSH in providing stimulation of radioiodine uptake (RAIU) for the ablation of thyroid remnant and/or malignant thyroid tissue in patients with metastatic DTC.
  • Ten subjects (4 women, 6 men), mean age 53 years, with DTC (7 papillary, 2 follicular and 1 Hürthle-cell), requiring radioiodine therapy (RIT) were studied.
  • The post-therapy WBS (pthWBS) showed:.
  • 1) additional metastatic lesions in 3 patients with positive dWBS, 2) lung nodular metastases in 1 patient with negative dWBS, 3) similar image as the dWBS in 4 patients, 4) negative image in 1 patient with positive dWBS.
  • [MeSH-major] Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Radiation Tolerance / drug effects. Thyroid Neoplasms / drug therapy. Thyroid Neoplasms / radiotherapy. Thyrotropin / administration & dosage
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant / methods. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Radiation-Sensitizing Agents / administration & dosage. Recombinant Proteins / administration & dosage. Recombinant Proteins / genetics. Treatment Outcome

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  • (PMID = 15318305.001).
  • [ISSN] 1506-9680
  • [Journal-full-title] Nuclear medicine review. Central & Eastern Europe
  • [ISO-abbreviation] Nucl Med Rev Cent East Eur
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Radiation-Sensitizing Agents; 0 / Recombinant Proteins; 9002-71-5 / Thyrotropin
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25. Stamatiou K, Papadopoulos P, Perlepes G, Galariotis N, Olympitis M, Moschouris H, Vasilakaki T: Mixed germ cell tumor of the testicle with ravdomuosarcomatous component: a case report. Cases J; 2009;2:9299

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Testicular tumors can be classified as seminomatous and non-seminomatous germ-cell tumor (NSGCT) types.
  • Here we present a rare case of a mixed germ cell tumor composed of seminoma, Yolk sack tumor and teratoma containing a sarcoma component of somatic type malignancy.
  • CT scan of the abdomen showed nodular metastasis involving the interaortocaval, precaval, and right para-aortic lymph nodes.
  • The patient underwent right-sided high orchidectomy and was given chemotherapy of the BEP regimen.
  • After the 2nd cycle the patient discontinued the chemotherapy and when he came for follow-up after a gap of 3 months, despite the normalisation in tumor markers values, the retroperitoneal mass was relapsed.
  • CT scan of the chest showed multiple lung metastases.
  • CONCLUSION: More than 50% of germ-cell tumors include more than 2 basic germ-cell tumor types, with the exception of spermatocytic seminoma.
  • About 90% of the patients with nonseminomatous tumors can achieve complete cure with aggressive chemotherapy and most of them can be cured.
  • Although prognosis of testicular tumors depends largely on clinical stage, histological type and adhesion to the treatment influence the prognosis as well.

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  • (PMID = 20062623.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803963
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26. Fadare O, Parkash V, Carcangiu ML, Hui P: Epithelioid trophoblastic tumor: clinicopathological features with an emphasis on uterine cervical involvement. Mod Pathol; 2006 Jan;19(1):75-82
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

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  • All five tumors were invasive, nodular lesions consisting of epithelioid intermediate trophoblastic cells that were mononuclear with abundant eosinophilic cytoplasm, along with zones of hyaline material and necrotic debris.
  • All patients received total hysterectomy and various regimes of adjuvant chemotherapy.
  • One patient is currently alive with lung metastasis 1 month after the surgery.
  • One patient died of tumor metastasis 8 months after the diagnosis.

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  • (PMID = 16258513.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 9035-54-5 / Placental Lactogen
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27. Williams SB, Ellis GL, Warnock GR: Sialoblastoma: a clinicopathologic and immunohistochemical study of 7 cases. Ann Diagn Pathol; 2006 Dec;10(6):320-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These tumors occurred in 4 males and 3 females with ages ranging from prenatal to 6 months at the time of discovery.
  • All lesions presented as nodular to multinodular swellings and ranged in size from 2.0 to 7.0 cm.
  • Treatment involved surgical excision.
  • One patient received adjuvant chemotherapy.
  • Two sialoblastomas resulted in recurrences within a year and another developed a recurrence after 4 years.
  • One sialoblastoma developed lung metastasis within 1 month of the original biopsy.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Immunoenzyme Techniques. Infant. Infant, Newborn. Ki-67 Antigen / analysis. Male. Neoplasm Recurrence, Local. Treatment Outcome. alpha-Fetoproteins / analysis

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  • (PMID = 17126248.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / alpha-Fetoproteins
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