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Items 1 to 29 of about 29
1. Ogimoto A, Hamada M, Ohtsuka T, Hara Y, Shigematsu Y, Yokoyama A, Imagawa H, Kawachi K, Kito K, Higaki J: Rapid progression of primary cardiac leiomyosarcoma with obstruction of the left ventricular outflow tract and mitral stenosis. Intern Med; 2003 Sep;42(9):827-30
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  • [Title] Rapid progression of primary cardiac leiomyosarcoma with obstruction of the left ventricular outflow tract and mitral stenosis.
  • We report a 73-year-old woman with primary cardiac leiomyosarcoma in the left atrium and ventricle.
  • She refused postoperative chemotherapy and radiotherapy, and died suddenly at home 89 days after surgery.
  • To our knowledge, this is the first observation of mitral stenosis concomitant with obstruction of the left ventricular outflow tract in a patient with primary cardiac leiomyosarcoma.
  • [MeSH-major] Atrial Fibrillation / etiology. Heart Neoplasms / complications. Leiomyosarcoma / complications. Mitral Valve Stenosis / etiology. Shock, Cardiogenic / etiology. Ventricular Outflow Obstruction / etiology
  • [MeSH-minor] Aged. Cardiac Surgical Procedures / methods. Echocardiography. Fatal Outcome. Female. Humans. Neoplasm Invasiveness. Tomography, X-Ray Computed. Treatment Refusal

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  • (PMID = 14518670.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Lee SH, Kim WH, Choi JB, Lee SR, Rhee KS, Chae JK, Ko JK: Huge primary pleomorphic leiomyosarcoma in the right ventricle with impending obstruction of both inflow and outflow tracts. Circ J; 2009 Apr;73(4):779-82
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  • [Title] Huge primary pleomorphic leiomyosarcoma in the right ventricle with impending obstruction of both inflow and outflow tracts.
  • Primary cardiac leiomyosarcoma is an extremely rare disease entity that is associated with very poor prognosis.
  • We describe here a 45-year-old man who had a huge pleomorphic leiomyosarcoma in the right ventricle (RV) that presented with signs of acute pressure and volume overload and impending obstruction of both outflow and inflow tracts of the RV.
  • We evaluated the extent of the tumor using various imaging modalities including transthoracic and transesophageal echocardiography, magnetic resonance imaging, computed tomography, and positron emission tomography-computed tomography.
  • The tumor has shown aggressive regrowth after surgery despite adjuvant chemotherapy.
  • [MeSH-major] Heart Neoplasms / pathology. Leiomyosarcoma / pathology. Positron-Emission Tomography
  • [MeSH-minor] Blood Flow Velocity. Heart Ventricles / pathology. Heart Ventricles / radiography. Humans. Male. Middle Aged

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  • (PMID = 19075518.001).
  • [ISSN] 1346-9843
  • [Journal-full-title] Circulation journal : official journal of the Japanese Circulation Society
  • [ISO-abbreviation] Circ. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Ceccaldi B, Dourthe LM, Garcin JM, Vergeau B, Chanudet X, Larroque P: [Leiomyosarcoma of the right ventricle]. Bull Cancer; 2000 Jul;87(7-8):547-50
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  • [Title] [Leiomyosarcoma of the right ventricle].
  • A 58-year-old woman has dyspnea and palpitations which reveal a leiomyosarcoma of the right ventricle.
  • In spite of chemotherapy (epirubicin-cyclophosphamide), relapse is observed with pulmonary metastases 17 months after the surgery.
  • The death becomes on 18 months in congestive heart failure.
  • From this case, the authors make a review of the literature about this exceptional tumour, and talk over the low possibilities of treatment, despite the capacities of the new ways of diagnosis.
  • [MeSH-major] Heart Neoplasms / diagnosis. Leiomyosarcoma / diagnosis

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  • (PMID = 10969212.001).
  • [ISSN] 0007-4551
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] FRANCE
  • [Number-of-references] 22
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4. Fahn W, Schlemmer M, Issels R, Uberfuhr P, Reichart B: [Leiomyosarcoma of the heart--interdisciplinary therapeutic approach of systemic chemotherapy and subsequent heart transplantation]. Dtsch Med Wochenschr; 2003 Sep 26;128(39):2005-8
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  • [Title] [Leiomyosarcoma of the heart--interdisciplinary therapeutic approach of systemic chemotherapy and subsequent heart transplantation].
  • [Transliterated title] Leiomyosarkom des Herzen--interdisziplinärer Therapieansatz mit systemischer Chemotherapie und anschliessender Herztransplantation.
  • Histologically it was a poorly differentiated leiomyosarcoma G 3, which could not be completely resected (R 2 resection).
  • TREATMENT AND COURSE: As part of a multimodal therapeutic approach he was given 6 cycles of chemotherapy (doxorubicin and ifosfamide), bringing about significant reduction of the tumor size.
  • The tumor was then completely resected, followed by an orthotopic heart transplantation with right pneumonectomy.
  • No tumor recurrence or distal metastasis was seen during a follow-up period of 36 months.
  • The patient died from right heart failure with advanced pulmonary hypertension 45 months after the diagnosis had first been made, 37 months after the cardiac transplantation.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Heart Neoplasms. Heart Transplantation. Leiomyosarcoma
  • [MeSH-minor] Adult. Combined Modality Therapy. Doxorubicin / therapeutic use. Fatal Outcome. Heart Atria. Humans. Ifosfamide / therapeutic use. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / surgery. Pneumonectomy


5. Canadyova J, Setina M, Smetanová S, Mokracek A: Leiomyosarcoma of the left atrium. Asian Cardiovasc Thorac Ann; 2008 Jan;16(1):e7-9
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  • [Title] Leiomyosarcoma of the left atrium.
  • A 41-year-old woman underwent successful excision of a leiomyosarcoma of the left atrium.
  • The preferential left atrial location and frequent myxoid appearance of leiomyosarcoma of the heart make it particularly difficult to distinguish preoperatively from atrial myxoma.
  • Early diagnosis and aggressive surgical intervention with chemotherapy may improve the prognosis.
  • [MeSH-major] Heart Neoplasms / diagnosis. Leiomyosarcoma / diagnosis. Myxoma / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Agents, Alkylating / therapeutic use. Cardiac Surgical Procedures. Chemotherapy, Adjuvant. Diagnosis, Differential. Echocardiography, Transesophageal. Female. Heart Atria / pathology. Humans. Ifosfamide / therapeutic use. Positron-Emission Tomography

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  • (PMID = 18245694.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; UM20QQM95Y / Ifosfamide
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6. Giuliante F, Sarno G, Ardito F, Pierconti F: Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge. Tumori; 2009 May-Jun;95(3):374-7
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  • [Title] Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge.
  • BACKGROUND: Primary leiomyosarcoma of the liver is a rare tumor whose development patterns are unsatisfactorily known.
  • PATIENT CASE: A 26-year-old male patient with a previous history of radiochemotherapy treatment for Hodgkin's lymphoma was referred to our unit with a histological and radiological diagnosis of primary hepatic leiomyosarcoma.
  • Shortly before referral the lesion had grown to 7.8 cm, associated with two smaller lesions in segments VIII and III, and a diagnosis of hepatic leiomyosarcoma was made at biopsy.
  • This was followed by rapid progression of the disease, in spite of transient stabilization under gemcitabine treatment.
  • Octreotide was also administered after the detection of elevated chromogranin A in serum.
  • CONCLUSIONS: The challenges and peculiarities of this case are related to the rarity of the tumor, its accidental discovery without immediate suspicion of its nature, its very aggressive behavior that was only partly controlled by chemotherapy, and the unusual expression of a neuroendocrine phenotypic feature with high serum chromogranin A levels.
  • [MeSH-major] Hodgkin Disease. Leiomyosarcoma. Liver Neoplasms. Neoplasms, Second Primary
  • [MeSH-minor] Adult. Fatal Outcome. Hepatectomy. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19688980.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Kieffer E, Alaoui M, Piette JC, Cacoub P, Chiche L: Leiomyosarcoma of the inferior vena cava: experience in 22 cases. Ann Surg; 2006 Aug;244(2):289-95
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  • [Title] Leiomyosarcoma of the inferior vena cava: experience in 22 cases.
  • There were 1 intraoperative death due to cardiac failure and 3 postoperative deaths due to multiple organ failure, liver failure, and duodenal fistula after treatment of a bleeding ulcer.
  • Fifteen of the 16 surviving patients underwent adjuvant chemotherapy associated with radiation therapy in 4 cases.
  • Eleven patients died after a mean follow-up period of 43.7 months due to local recurrence and/or distant metastasis in 9 cases and complications of chemotherapy in 2.
  • Leiomyosarcoma of the IVC is a serious disease.
  • Although surgical resection combined with chemotherapy is usually not curative, it can achieve reasonably long-term survival.
  • [MeSH-major] Leiomyosarcoma / surgery. Vascular Neoplasms / surgery. Vena Cava, Inferior / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blood Vessel Prosthesis Implantation. Cause of Death. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Heart Arrest, Induced. Heart Neoplasms / surgery. Humans. Hypothermia, Induced. Intraoperative Complications. Ligation. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Polytetrafluoroethylene. Postoperative Complications. Radiotherapy, Adjuvant. Survival Rate

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  • (PMID = 16858193.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-84-0 / Polytetrafluoroethylene
  • [Other-IDs] NLM/ PMC1602179
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8. Parissis H, Akbar MT, Young V: Primary leiomyosarcoma of the right atrium: a case report and literature update. J Cardiothorac Surg; 2010;5:80
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  • [Title] Primary leiomyosarcoma of the right atrium: a case report and literature update.
  • Leiomyosarcoma of the right atrium is a very rare cardiac tumor.
  • Various combinations of treatments including resection or transplant surgery and Chemotherapy have been advocated.
  • We report a case of a man who presented with pulmonary embolism secondary to right atrial leiomyosarcoma.
  • Postoperatively tumor dissemination was controlled with adjuvant chemotherapy.A vigorous attempt aiming at tumor clearance followed by adjuvant multimodality therapy along with a tumor surveillance program may improve survival.
  • [MeSH-major] Heart Neoplasms. Leiomyosarcoma
  • [MeSH-minor] Adult. Heart Atria. Humans. Male. Pulmonary Embolism / etiology

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  • (PMID = 20939891.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2964688
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9. Evans BJ, Haw MP: Surgical clearance of invasive cardiac leiomyosarcoma with concomitant pneumonectomy. Eur J Cardiothorac Surg; 2003 Nov;24(5):843-6
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  • [Title] Surgical clearance of invasive cardiac leiomyosarcoma with concomitant pneumonectomy.
  • The management of cardiac leiomyosarcoma is still controversial.
  • Due to the rare occurrence and late presentation of such tumours the treatment is essentially palliative.
  • Postoperatively, adjuvant chemotherapy and/or radiotherapy may have a role.
  • [MeSH-major] Heart Neoplasms / surgery. Leiomyosarcoma / surgery. Pneumonectomy / methods
  • [MeSH-minor] Adult. Cardiac Surgical Procedures / methods. Female. Humans

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  • (PMID = 14583324.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 10
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10. Dhall D, Al-Ahmadie HA, Dhall G, Shen-Schwarz S, Tickoo SK: Pediatric renal cell carcinoma with oncocytoid features occurring in a child after chemotherapy for cardiac leiomyosarcoma. Urology; 2007 Jul;70(1):178.e13-5
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  • [Title] Pediatric renal cell carcinoma with oncocytoid features occurring in a child after chemotherapy for cardiac leiomyosarcoma.
  • We report a case of renal cell carcinoma (RCC) with extensive oncocytoid features developing in a 12-year-old African-American boy after chemotherapy for cardiac leiomyosarcoma at 3 months of age.
  • The tumor showed histopathologic features similar to those previously reported in RCC after chemotherapy for neuroblastoma and now considered a specific entity in the World Health Organization classification of renal tumors as "RCC associated with neuroblastoma."
  • Our report expands the spectrum of tumors (beyond neuroblastoma) in which RCCs with such an appearance can arise in the pediatric age group after chemotherapy.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Heart Neoplasms / drug therapy. Kidney Neoplasms / pathology. Leiomyosarcoma / drug therapy. Neoplasms, Second Primary / pathology

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  • (PMID = 17656235.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Gehrmann J, Kehl HG, Diallo R, Debus V, Vogt J: Cardiac leiomyosarcoma of the right atrium in a teenager: unusual manifestation with a lifetime history of atrial ectopic tachycardia. Pacing Clin Electrophysiol; 2001 Jul;24(7):1161-4
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  • [Title] Cardiac leiomyosarcoma of the right atrium in a teenager: unusual manifestation with a lifetime history of atrial ectopic tachycardia.
  • Transesophageal echocardiography revealed a right atrial leiomyosarcoma.
  • Her past medical history was remarkable for incessant atrial ectopic tachycardia (AET) beginning in early infancy and continuing throughout childhood and adolescence that was refractive to medical and nonpharmacological treatment.
  • After combined surgical and medical therapy, normal sinus rhythm was restored and the patient is currently in complete remission with no recurrent symptoms or atrial arrhythmias at 31 months after surgery and 23 months after the discontinuation of chemotherapy.
  • Atrial tachycardia may be the first, and for prolonged periods, the only manifestation of a cardiac tumor and should prompt thorough investigation of its underlying morphological substrate.
  • [MeSH-major] Heart Atria. Heart Neoplasms / diagnosis. Leiomyosarcoma / diagnosis. Tachycardia, Ectopic Atrial / complications

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  • (PMID = 11475835.001).
  • [ISSN] 0147-8389
  • [Journal-full-title] Pacing and clinical electrophysiology : PACE
  • [ISO-abbreviation] Pacing Clin Electrophysiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Jafari Giv M, Kenny JF, Opeskin KK, Elahi MM, Alam NZ: Surgical treatment of ruptured metastatic pleomorphic leiomyosarcoma. Asian Cardiovasc Thorac Ann; 2010 Jun;18(3):288-90
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  • [Title] Surgical treatment of ruptured metastatic pleomorphic leiomyosarcoma.
  • A rare case of primary cardiac leiomyosarcoma was diagnosed in a 21-year-old man who presented with a groin mass thought to be a sebaceous cyst.
  • Histopathology revealed a high-grade pleomorphic leiomyosarcoma.
  • Combined positron-emission and computed tomography showed a large metabolically active left atrial mass with multiple metastases.
  • Major debulking resection was undertaken, followed by radiation and chemotherapy.
  • [MeSH-major] Cardiac Surgical Procedures. Heart Neoplasms / surgery. Leiomyosarcoma / surgery
  • [MeSH-minor] Cardiac Tamponade / etiology. Cardiac Tamponade / surgery. Chemotherapy, Adjuvant. Echocardiography. Groin. Heart Atria / pathology. Heart Atria / surgery. Humans. Male. Positron-Emission Tomography. Radiotherapy, Adjuvant. Rupture, Spontaneous. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20519300.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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13. Schröder S, Walker T, Greschniok A, Herdeg C, Karsch KR, Ziemer G: Primary cardiac leiomyosarcoma originating from the pulmonary valve. Case report and review of the literature. J Cardiovasc Surg (Torino); 2001 Feb;42(1):53-6
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  • [Title] Primary cardiac leiomyosarcoma originating from the pulmonary valve. Case report and review of the literature.
  • Primary cardiac tumours are rare findings (incidence 0.02% according to a recent meta-analysis) with dismal prognosis.
  • Treatment for primary cardiac leiomyosarcomas consists of radical surgical resection followed by adjuvant radiation therapy and/or chemotherapy.
  • The mean survival after surgery and adjuvant therapies is 6.8 months.
  • We present a rare case of a 40- year-old male patient with a primary cardiac leiomysarcoma originating from the pulmonary valve.
  • [MeSH-major] Heart Neoplasms. Leiomyosarcoma

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  • (PMID = 11292906.001).
  • [ISSN] 0021-9509
  • [Journal-full-title] The Journal of cardiovascular surgery
  • [ISO-abbreviation] J Cardiovasc Surg (Torino)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 27
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14. Imbert S, Laffort P, Deville C, Bonnel C, De Mascarel A, Roudaut R: [Primitive leiomyosarcoma of the right atrium presenting with a pulmonary embolism]. Arch Mal Coeur Vaiss; 2000 Feb;93(2):199-202
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  • [Title] [Primitive leiomyosarcoma of the right atrium presenting with a pulmonary embolism].
  • [Transliterated title] Léiomyosarcome primitif de l'oreillette droite révélé par une embolie pulmonaire.
  • Primary Cardiac leiomyosarcoma is a very rare condition.
  • Despite thrombolytic therapy, a persistent poor haemodynamic condition associated with a superior vena cava syndrome led to a transoesophageal echocardiographic examination which demonstrated an abnormal intra-right atrial mass obstructing the tricuspid valve.
  • During systematic three-monthly clinical and echocardiographic follow-up, transoesophageal echocardiography detected an asymptomatic local recurrence at 15 months, for which surgery was repeated with adjuvant chemotherapy.
  • [MeSH-major] Heart Neoplasms / pathology. Leiomyosarcoma / pathology. Pulmonary Embolism / etiology
  • [MeSH-minor] Diagnosis, Differential. Echocardiography, Transesophageal. Female. Heart Atria. Hemodynamics. Humans. Middle Aged. Neoplasm Recurrence, Local. Superior Vena Cava Syndrome / etiology. Treatment Outcome

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  • (PMID = 10830098.001).
  • [ISSN] 0003-9683
  • [Journal-full-title] Archives des maladies du coeur et des vaisseaux
  • [ISO-abbreviation] Arch Mal Coeur Vaiss
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] FRANCE
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15. Comandone A, Boglione A, Pochettino P, Berno E, Inguì M, Papotti M, Borasio P, Maggi G, Brach Del Prever E, Gino G: Primary sarcomas of the lungs and mediastinum: Clinicopathological study and therapy results of Piedmontese Group for Sarcomas. J Clin Oncol; 2009 May 20;27(15_suppl):e21509

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  • [Title] Primary sarcomas of the lungs and mediastinum: Clinicopathological study and therapy results of Piedmontese Group for Sarcomas.
  • : e21509 Background: Primary sarcomas of the lungs and mediastinum are rare and few data are reported on treatment and results of therapy.
  • 5 mediastinal tumours were located as follows: 2 in anterior part, 1 in posterior and 2 in the middle (sarcomas of the heart).
  • Neoadjuvant chemotherapy was performed in 4 cases (3 resected).
  • The histology were: peripheral nerve tumour 7, leiomyosarcoma 4, MFH 2, fibrosarcoma 2, liposarcoma 1, angiosarcoma 2, undifferentiated sarcoma 1, solitary fibrous tumour 2, rhabdomyosarcoma 2, synovialsarcoma 2, pulmonary artery sarcoma 1, pleuropolmonary blastoma 1, malignant hemangiopericytoma 1, mixoid chondrosarcoma 1, ectopic osteosarcoma 1, aggressive fibromatosis 1.
  • Only 4 pts received neoadjuvant chemotherapy, 11 adjuvant CT, 5 exclusive CT + RT for inoperable disease.
  • Surgical resection is the fundamental therapy, but in the future the role of neoadjuvant CT will increase.

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  • (PMID = 27963441.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Indelicato DJ, Keole SR, Shahlaee AH, Morris CG, Gibbs CP, Scarborough MT, Islam S, Marcus RB: Ewing tumors of the chest wall: Local control and long-term outcomes. J Clin Oncol; 2009 May 20;27(15_suppl):e21501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e21501 Background: Primary sarcomas of the lungs and mediastinum are rare and few data are reported on treatment and results of therapy.
  • 5 mediastinal tumours were located as follows: 2 in anterior part, 1 in posterior and 2 in the middle (sarcomas of the heart).
  • Neoadjuvant chemotherapy was performed in 4 cases (3 resected).
  • The histology were: peripheral nerve tumour 7, leiomyosarcoma 4, MFH 2, fibrosarcoma 2, liposarcoma 1, angiosarcoma 2, undifferentiated sarcoma 1, solitary fibrous tumour 2, rhabdomyosarcoma 2, synovialsarcoma 2, pulmonary artery sarcoma 1, pleuropolmonary blastoma 1, malignant hemangiopericytoma 1, mixoid chondrosarcoma 1, ectopic osteosarcoma 1, aggressive fibromatosis 1.
  • Only 4 pts received neoadjuvant chemotherapy, 11 adjuvant CT, 5 exclusive CT + RT for inoperable disease.
  • Surgical resection is the fundamental therapy, but in the future the role of neoadjuvant CT will increase.

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  • (PMID = 27963390.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Moreno Antón F, Casado Herraez A, Puente Vázquez J, Gómez Díaz R, Aragoncillo P, Díaz-Rubio García E: Cardiac metastasis from uterine leiomyosarcoma. Clin Transl Oncol; 2006 May;8(5):375-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac metastasis from uterine leiomyosarcoma.
  • Cardiac metastases are more frequent than primary heart neoplasias.
  • Nearly any malignant tumour may metastasize to the heart, but the most common are carcinomas rather than sarcomas.
  • We report the case of a patient who presented with heart metastasis 6 years after resection of an uterine leiomyosarcoma.
  • The patient died thirty months after surgical resection without evidence of cardiac recurrence.
  • Although cardiac metastases from uterine leiomyosarcoma are exceptional, they should be suspected in the presence of suggestive symptoms, since they can be associated with long survival after surgical treatment.
  • [MeSH-major] Heart Neoplasms / secondary. Leiomyosarcoma / secondary. Uterine Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Dacarbazine / administration & dosage. Dacarbazine / analogs & derivatives. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Diagnostic Errors. Doxorubicin / administration & dosage. Fatal Outcome. Female. Humans. Hysterectomy. Ifosfamide / administration & dosage. Kidney Neoplasms / drug therapy. Kidney Neoplasms / secondary. Kidney Neoplasms / surgery. Leiomyoma / diagnosis. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Middle Aged. Ovariectomy. Taxoids / administration & dosage. Thoracic Surgery, Video-Assisted

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  • [Cites] Can J Surg. 1988 Nov;31(6):418-20 [3179851.001]
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  • (PMID = 16760015.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Taxoids; 0W860991D6 / Deoxycytidine; 15H5577CQD / docetaxel; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; B76N6SBZ8R / gemcitabine; UM20QQM95Y / Ifosfamide; YF1K15M17Y / temozolomide
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18. Garraud M, Margery J, Laborde F, Saint-Blancard P, David S, Bonardel G, Héno P: [Pulmonary vein leiomyosarcoma extending into the left atrium]. Rev Pneumol Clin; 2010 Oct;66(5):321-5
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  • [Title] [Pulmonary vein leiomyosarcoma extending into the left atrium].
  • In this paper, the authors report the case of a 28-year-old man with pulmonary vein leiomyosarcoma presenting subacute respiratory distress.
  • Thoracic computed tomography and transoesophagal ultrasonographic examination of the heart suggested the diagnosis of a heart tumour revealed by the obstruction of the mitral valve and pulmonary oedema.
  • Emergency cardiac surgery revealed the mass to be a leiomyosarcoma, probably extending from the right inferior pulmonary vein and extending into the left atrium.
  • The patient underwent a second cardiac intervention involving lower right lobectomy followed by adjuvant chemotherapy with an ifosfamide-adriamycin combination.
  • This treatment failed to control the disease and a third cardiac intervention was necessary with second-line gemcitabine-paclitaxel adjuvant chemotherapy.
  • [MeSH-major] Heart Atria / pathology. Heart Neoplasms / pathology. Leiomyosarcoma / diagnosis. Pulmonary Veins / pathology. Vascular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Echocardiography, Transesophageal. Fatal Outcome. Humans. Male. Military Personnel. Mitral Valve / pathology. Neoadjuvant Therapy. Neoplasm Recurrence, Local / pathology. Pulmonary Edema / diagnosis. Respiratory Insufficiency / diagnosis. Tomography, X-Ray Computed

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21087728.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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19. Bonatti H, Hoefer D, Rogatsch H, Margreiter R, Larcher C, Antretter H: Successful management of recurrent Epstein-Barr virus-associated multilocular leiomyosarcoma after cardiac transplantation. Transplant Proc; 2005 May;37(4):1839-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful management of recurrent Epstein-Barr virus-associated multilocular leiomyosarcoma after cardiac transplantation.
  • CASE REPORT: Two years after heart transplantation with ATG induction, cyclosporine (CsA; trough levels of 250 ng/mL)-based triple drug immunosuppression), a 23-year-old patient developed a small round lesion within the left lateral liver segment.
  • Histological and immunohistological examination showed a leiomyosarcoma.
  • Immunosuppression was drastically reduced, namely, CsA levels <100 ng/dL, prednisolone 5 mg, azathioprine withdrawn, and antiviral chemotherapy initiated with 10 days of IV gancyclovir and acyclovir followed by oral famcyclovir.
  • Eighteen months post-liver resection, and high-resolution computed tomography scan demonstrated two paravertebral tumors.
  • Immunosuppression was further reduced (CsA levels 75 ng/dL) and famcyclovir maintenance therapy started.
  • Nevertheless, 2 years later the patient again developed tumor recurrence (perirectal, liver, and right adrenal gland); the tumors were surgically removed.
  • The therapy was switched to Rapamycin and famcyclovir was continued.
  • CONCLUSION: Long-term survival in patients with posttransplant EBV-associated leiomyosarcoma can be achieved by combined surgical intervention, reduction of immunosuppression, switch to Sirolimus, and antiviral chemotherapy.
  • [MeSH-major] Epstein-Barr Virus Infections / drug therapy. Heart Transplantation / methods. Leiomyosarcoma / surgery. Liver Neoplasms / surgery
  • [MeSH-minor] Acyclovir / therapeutic use. Adult. Antiviral Agents / therapeutic use. Cardiomyopathy, Dilated / surgery. Ganciclovir / therapeutic use. Humans. Male. Microsurgery. Recurrence. Tomography, X-Ray Computed. Treatment Outcome


20. Vander Salm TJ: Unusual primary tumors of the heart. Semin Thorac Cardiovasc Surg; 2000 Apr;12(2):89-100
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  • [Title] Unusual primary tumors of the heart.
  • Primary tumors of the heart, with the exception of atrial myxomas, occur rarely; tumors metastatic to or directly invasive of the heart are far more common.
  • The malignant tumors consist of various sarcomas: myxosarcoma, liposarcoma, angiosarcoma, fibrosarcoma, leiomyosarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, undifferentiated sarcoma, reticulum cell sarcoma, neurofibrosarcoma, and malignant fibrous histiocytoma.
  • Cardiac tumors produce a large variety of symptoms through any of 4 mechanisms.
  • Bits of tumor can embolize, causing systemic deficits when the tumors are on the left side of the heart.
  • The echocardiographic appearance may also allow quite accurate prediction of the tumor type and whether it is malignant or benign.
  • Magnetic resonance imaging serves as the next most important test where the density of T1 and T2 images may allow tumor cell type identification.
  • Heart transplantation should be considered for these patients.
  • For patients with unresectable sarcomas, radiation and chemotherapy may be used, but without great expectation of successful results.
  • [MeSH-major] Heart Neoplasms / diagnosis. Heart Neoplasms / surgery
  • [MeSH-minor] Fibroma / diagnosis. Fibroma / surgery. Hamartoma / diagnosis. Hamartoma / surgery. Heart Septum / pathology. Heart Transplantation. Hemangioma / diagnosis. Hemangioma / surgery. Humans. Hypertrophy. Mesothelioma / diagnosis. Mesothelioma / surgery. Pheochromocytoma / diagnosis. Pheochromocytoma / surgery. Prognosis. Rhabdomyoma / diagnosis. Rhabdomyoma / surgery. Teratoma / diagnosis. Teratoma / surgery

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  • (PMID = 10807431.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] UNITED STATES
  • [Number-of-references] 69
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21. Uberfuhr P, Meiser B, Fuchs A, Schulze C, Reichenspurner H, Falk M, Weiss M, Wintersperger B, Issels R, Reichart B: Heart transplantation: an approach to treating primary cardiac sarcoma? J Heart Lung Transplant; 2002 Oct;21(10):1135-9
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  • [Title] Heart transplantation: an approach to treating primary cardiac sarcoma?
  • Treating rare, primary cardiac soft-tissue sarcomas (C-STS) with heart transplantation (HTx) is controversial.
  • Heart transplantation offers the opportunity to eradicate the primary malignancy completely.
  • In our experience of 4 patients with C-STS indicates, HTx followed by post-operative chemotherapy does not affect the long-term outcome.
  • However, pre-operative chemotherapy can regress tumors in chemosensitive C-STS and potentially eradicate early micrometastases.
  • [MeSH-major] Heart Neoplasms / surgery. Heart Transplantation. Sarcoma / surgery
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Female. Hemangiopericytoma / drug therapy. Hemangiopericytoma / surgery. Hemangiosarcoma / drug therapy. Hemangiosarcoma / surgery. Humans. Leiomyosarcoma / drug therapy. Leiomyosarcoma / surgery. Prognosis. Treatment Outcome

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  • (PMID = 12398881.001).
  • [ISSN] 1053-2498
  • [Journal-full-title] The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • [ISO-abbreviation] J. Heart Lung Transplant.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Mayer F, Aebert H, Rudert M, Königsrainer A, Horger M, Kanz L, Bamberg M, Ziemer G, Hartmann JT: Primary malignant sarcomas of the heart and great vessels in adult patients--a single-center experience. Oncologist; 2007 Sep;12(9):1134-42
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  • [Title] Primary malignant sarcomas of the heart and great vessels in adult patients--a single-center experience.
  • BACKGROUND: Sarcomas arising in the heart or the great vessels are rare entities.
  • METHODS: Between January 1993 and September 2006, of 1,429 patients registered to the Sarcoma Center, 14 had a primary sarcoma of the heart or large vessels.
  • The most frequently encountered histologic subtypes were leiomyosarcoma and angiosarcoma.
  • Of those, two developed local recurrence within 2 and 10 months from surgery.
  • Eleven patients received palliative chemotherapy, seven of those as initial treatment.
  • Eight patients attained a response to treatment, two had disease stabilization for 6 and 12 months.
  • CONCLUSIONS: Patients with primary sarcomas of the heart and the large vessels were of a young age, and more than half of them presented with advanced disease.
  • Given the promising response to chemotherapy, an optimized treatment approach including neoadjuvant chemo-/radiotherapy in patients with locally advanced disease should be pursued.
  • [MeSH-major] Heart Neoplasms / epidemiology. Sarcoma / epidemiology. Vascular Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aortic Diseases / epidemiology. Female. Follow-Up Studies. Germany / epidemiology. Hemangiosarcoma / epidemiology. Humans. Leiomyosarcoma / epidemiology. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoadjuvant Therapy / statistics & numerical data. Pulmonary Artery / pathology. Remission Induction. Retrospective Studies. Survival Rate. Venae Cavae / pathology

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  • (PMID = 17914083.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Grande AM, Rinaldi M, Sinelli S, D'Armini AM, Viganŏ M: Heart transplantation in chemotherapeutic dilated cardiomyopathy. Transplant Proc; 2003 Jun;35(4):1516-8
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  • [Title] Heart transplantation in chemotherapeutic dilated cardiomyopathy.
  • Nine patients (four men) experienced postchemotherapy DCM: age at time of tumour diagnosis ranged from 1-45 years (mean 13.5 +/- 19 years); interval time between tumour and HT was 3-23 years (mean 10.8 +/- 6.6) and age at HT ranged from 10-65 years (30.8 +/- 20.1).
  • Interval between end of chemotherapy and beginning of cardiac symptoms was 5.71 +/- 4.6 years.
  • Interval between start of chemotherapy and DCM ranged from 1 month to 10 years (mean 3.15 +/- 3.6 years).
  • Tumours were Ewing sarcoma (7-year-old boy), paratesticular rabdomyosarcoma (1-year-old boy), Wilms tumor with pulmonary metastasis (3-year-old girl), bilateral breast carcinoma (45-year-old woman), uterine leiomyosarcoma (44-year-old woman), acute myelocytic leukemia (1.5-year-old boy and 17-year-old girl), and chronic myelocytic leukemia (5-year-old boy).
  • [MeSH-major] Antineoplastic Agents / adverse effects. Cardiomyopathy, Dilated / chemically induced. Cardiomyopathy, Dilated / surgery. Heart Transplantation / physiology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Neoplasms / classification. Neoplasms / drug therapy. Treatment Outcome


24. Neragi-Miandoab S, Kim J, Vlahakes GJ: Malignant tumours of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol (R Coll Radiol); 2007 Dec;19(10):748-56
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  • [Title] Malignant tumours of the heart: a review of tumour type, diagnosis and therapy.
  • Primary cardiac neoplasms are rare and occur less commonly than metastatic disease of the heart.
  • In this overview, current published studies concerning malignant neoplasms of the heart are reviewed, together with some insights into their aetiology, diagnosis and management.
  • We searched medline using the subject 'cardiac neoplasms'.
  • Sarcomas are the most common cardiac tumours and include myxosarcoma, liposarcoma, angiosarcoma, fibrosarcoma, leiomyosarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, neurofibrosarcoma, malignant fibrous histiocytoma and undifferentiated sarcoma.
  • The classic symptoms of cardiac tumours are intracardiac obstruction, signs of systemic embolisation, and systemic or constitutional symptoms.
  • Echocardiography and angiography are essential diagnostic tools for evaluating cardiac neoplasms.
  • Computed tomography and magnetic resonance imaging studies have improved the diagnostic approach in recent decades.
  • Successful treatment for benign cardiac tumours is usually achieved by surgical resection.
  • In conclusion, there are limited published data concerning cardiac neoplasms.
  • Surgery is the cornerstone of therapy.
  • However, a multi-treatment approach, including chemotherapy, radiation as well as evolving approaches such as gene therapy, might provide a better palliative and curative result.
  • [MeSH-major] Heart Neoplasms. Sarcoma
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cardiovascular Surgical Procedures. Echocardiography, Three-Dimensional. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17693068.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 77
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25. Swartz MF, Fink GW, Carhart RL Jr: Use of a biventricular assist device in the treatment of acute doxorubicin-induced cardiotoxicity. Congest Heart Fail; 2004 Jul-Aug;10(4):197-9
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  • [Title] Use of a biventricular assist device in the treatment of acute doxorubicin-induced cardiotoxicity.
  • This report describes a patient treated for metastatic leiomyosarcoma, who acutely developed doxorubicin-induced cardiotoxicity, and consequently developed heart failure.
  • Medical therapy was initiated; however, her condition deteriorated and a surgical alternative was proposed.
  • During the next 9 days while on the assist device, her heart failure resolved, her organs were well perfused, and her heart entered a recovery period.
  • Although the patient's cardiac function did not have long-term recovery, short-term recovery after doxorubicin toxicity was achieved.
  • The authors maintain that the use of a biventricular assist device in the treatment of acute heart failure resulting from doxorubicin-induced cardiomyopathy is an effective way to manage this patient population.
  • [MeSH-major] Antibiotics, Antineoplastic / adverse effects. Cardiovascular Diseases / chemically induced. Doxorubicin / adverse effects. Heart-Assist Devices
  • [MeSH-minor] Acute Disease. Adult. Fatal Outcome. Female. Heart Failure / therapy. Humans. Leiomyosarcoma / drug therapy. Terminal Care

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  • (PMID = 15314480.001).
  • [ISSN] 1527-5299
  • [Journal-full-title] Congestive heart failure (Greenwich, Conn.)
  • [ISO-abbreviation] Congest Heart Fail
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 80168379AG / Doxorubicin
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26. Vincelj J, Sokol I, Biotcić S, Sutlić Z, Biocina B, Rudez I: [Significance of transesophageal echocardiography in the diagnosis of atrial tumor]. Med Arh; 2005;59(4):235-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: We detected 16 atrial myxomas in 15 patients, one fibroelastoma, one leiomyosarcoma, and one metastatic adenocarcinoma.
  • The fibroelastoma, leiomyosarcoma, and metastatic carcinoma were found in right atrium.
  • There was no false negative TEE diagnosis, was one false positive diagnosis, yielding a 95% sensitivity and specifity of TEE in detection atrial tumor.
  • Seventeen patients referred for cardiac surgery, and TEE diagnosis was confirmed by pathohistology.
  • This patient treated with chemotherapy and radiotherapy because pulmonary adenocarcinoma.
  • CONCLUSION: Results of this work suggested that TEE is a safe procedure, high sensitive and specific, and accurate in the diagnosis of atrial tumors.
  • The ability of TEE to visualize both atria with great diagnostic accuracy makes it a very valuable procedure in the detection of atrial tumors.
  • [MeSH-major] Echocardiography, Transesophageal. Heart Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Female. Heart Atria. Humans. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 16018390.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] bos
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bosnia and Herzegovina
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27. Kramm T, Gaumann A, Heussel CP, Dahm M, Oelert H, Mayer E: [Surgical management of pulmonary artery sarcoma]. Dtsch Med Wochenschr; 2001 Dec 14;126(50):1423-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Chirurgische Therapie des Pulmonalarteriensarkoms.
  • The presentation is one of central pulmonary artery obstruction and progressive right-heart failure.
  • Malignancy was suspected in six of these patients by means of computed tomography (CT) and magnetic resonance tomography (MRT).
  • Seven patients received adjuvant radio- and/or chemotherapy.
  • Adjuvant therapy might bring additional benefit.
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Leiomyosarcoma / complications. Leiomyosarcoma / diagnosis. Leiomyosarcoma / surgery. Magnetic Resonance Imaging. Male. Mesenchymoma / complications. Mesenchymoma / diagnosis. Mesenchymoma / surgery. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local / pathology. Pneumonectomy. Prognosis. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 11743678.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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28. Kilickap S, Akgul E, Aksoy S, Aytemir K, Barista I: Doxorubicin-induced second degree and complete atrioventricular block. Europace; 2005 May;7(3):227-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Doxorubicin is one of the most effective chemotherapeutic agents used in the treatment of malignancies.
  • Although cardiomyopathy is the most well known side effect of doxorubicin, it usually occurs many years after the treatment and relates to cumulative doxorubicin dosage.
  • Another form of doxorubicin cardiotoxicity is arrhythmia which may occur at any time and after any dosage.
  • [MeSH-major] Antibiotics, Antineoplastic / adverse effects. Doxorubicin / adverse effects. Heart Block / chemically induced
  • [MeSH-minor] Adult. Duodenal Neoplasms / drug therapy. Female. Humans. Leiomyosarcoma / drug therapy

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  • (PMID = 15878560.001).
  • [ISSN] 1099-5129
  • [Journal-full-title] Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • [ISO-abbreviation] Europace
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 80168379AG / Doxorubicin
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29. Penel N, Adenis A, Mailliez A, Bonneterre J: Silent hereditary hematochromatosis as a susceptibility factor of doxorubicin-induced acute cardiac failure. Ann Oncol; 2010 Nov;21(11):2293-4
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  • [Title] Silent hereditary hematochromatosis as a susceptibility factor of doxorubicin-induced acute cardiac failure.

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  • (PMID = 20937649.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 80168379AG / Doxorubicin
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