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1. Giuliante F, Sarno G, Ardito F, Pierconti F: Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge. Tumori; 2009 May-Jun;95(3):374-7
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  • [Title] Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge.
  • BACKGROUND: Primary leiomyosarcoma of the liver is a rare tumor whose development patterns are unsatisfactorily known.
  • PATIENT CASE: A 26-year-old male patient with a previous history of radiochemotherapy treatment for Hodgkin's lymphoma was referred to our unit with a histological and radiological diagnosis of primary hepatic leiomyosarcoma.
  • Six months before referral, in a workup for hypertension, a CT scan of the abdomen had shown a 2.5-cm lesion in liver segment VII, which was interpreted as an angioma.
  • Shortly before referral the lesion had grown to 7.8 cm, associated with two smaller lesions in segments VIII and III, and a diagnosis of hepatic leiomyosarcoma was made at biopsy.
  • This was followed by rapid progression of the disease, in spite of transient stabilization under gemcitabine treatment.
  • Octreotide was also administered after the detection of elevated chromogranin A in serum.
  • The patient died 25 months after liver resection.
  • CONCLUSIONS: The challenges and peculiarities of this case are related to the rarity of the tumor, its accidental discovery without immediate suspicion of its nature, its very aggressive behavior that was only partly controlled by chemotherapy, and the unusual expression of a neuroendocrine phenotypic feature with high serum chromogranin A levels.
  • [MeSH-major] Hodgkin Disease. Leiomyosarcoma. Liver Neoplasms. Neoplasms, Second Primary
  • [MeSH-minor] Adult. Fatal Outcome. Hepatectomy. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19688980.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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2. Mayer F, Aebert H, Rudert M, Königsrainer A, Horger M, Kanz L, Bamberg M, Ziemer G, Hartmann JT: Primary malignant sarcomas of the heart and great vessels in adult patients--a single-center experience. Oncologist; 2007 Sep;12(9):1134-42
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  • The most frequently encountered histologic subtypes were leiomyosarcoma and angiosarcoma.
  • Six patients presented with distant metastases to the lungs (n = 5), lymph nodes (n = 2), and liver (n = 1).
  • Of those, two developed local recurrence within 2 and 10 months from surgery.
  • Eleven patients received palliative chemotherapy, seven of those as initial treatment.
  • Eight patients attained a response to treatment, two had disease stabilization for 6 and 12 months.
  • After a median follow-up of 14.5 months (range, 2-156), three patients were alive with no evidence of disease 11, 52, and 156 months after diagnosis.
  • Given the promising response to chemotherapy, an optimized treatment approach including neoadjuvant chemo-/radiotherapy in patients with locally advanced disease should be pursued.
  • [MeSH-minor] Adult. Aortic Diseases / epidemiology. Female. Follow-Up Studies. Germany / epidemiology. Hemangiosarcoma / epidemiology. Humans. Leiomyosarcoma / epidemiology. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Neoadjuvant Therapy / statistics & numerical data. Pulmonary Artery / pathology. Remission Induction. Retrospective Studies. Survival Rate. Venae Cavae / pathology

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  • (PMID = 17914083.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Lang H, Nussbaum KT, Kaudel P, Frühauf N, Flemming P, Raab R: Hepatic metastases from leiomyosarcoma: A single-center experience with 34 liver resections during a 15-year period. Ann Surg; 2000 Apr;231(4):500-5
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  • [Title] Hepatic metastases from leiomyosarcoma: A single-center experience with 34 liver resections during a 15-year period.
  • OBJECTIVE: To describe a large single-center experience with hepatic resection for metastatic leiomyosarcoma.
  • SUMMARY BACKGROUND DATA: Liver resection is the treatment of choice for hepatic metastases from colorectal carcinoma.
  • In contrast, the role of liver resection for hepatic metastases from leiomyosarcoma has not been defined.
  • METHODS: The records of 26 patients who between 1982 and 1996 underwent a total of 34 liver resections for hepatic metastases from leiomyosarcoma were reviewed.
  • There were 23 first, 9 second, and 2 third liver resections.
  • RESULTS: In the 23 first liver resections, there were 15 R0, 3 R1, and 5 R2 resections.
  • In 10 patients with extrahepatic tumor at the time of the first liver resection, 6 R0 and 4 R2 resections were achieved.
  • After repeat liver resection, the median survival was 31 months (range 5-51 months); after R0 resection, median survival was 31 months and after R1/2 resection it was 28 months.
  • There was no 5-year survivor in the overall group after repeat liver resection.
  • CONCLUSIONS: Despite frequent tumor recurrence, the long-term outcome after liver resection for hepatic metastases from leiomyosarcoma is superior to that after chemotherapy and chemoembolization.
  • Although survival after tumor debulking also seems to be more favorable than after nonoperative therapy, these data indicate that only an R0 resection offers the chance of long-term survival.
  • The presence of extrahepatic tumor should not be considered a contraindication to liver resection if complete removal of all tumorous masses appears possible.
  • In selected cases of intrahepatic tumor recurrence, even repeated liver resection might be worthwhile.
  • In view of the poor results of chemoembolization and chemotherapy in hepatic metastases from leiomyosarcoma, liver resection should be attempted whenever possible.
  • [MeSH-major] Colorectal Neoplasms / pathology. Hepatectomy. Leiomyosarcoma / secondary. Leiomyosarcoma / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery

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  • (PMID = 10749609.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Other-IDs] NLM/ PMC1421024
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4. Takashima M, Igaki N, Matsuda T, Ohyama M, Kanda S, Tamada F, Goto T: Malignant gastrointestinal stromal tumor of the small intestine complicated with pulmonary tuberculosis during treatment with imatinib mesylate. Intern Med; 2005 Feb;44(2):114-9
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  • [Title] Malignant gastrointestinal stromal tumor of the small intestine complicated with pulmonary tuberculosis during treatment with imatinib mesylate.
  • We describe a patient who had a metastatic gastrointestinal stromal tumor (GIST) after previous failed extensive therapy, including multiple surgeries and hepatic artery embolization.
  • Within a few months of starting administration of imatinib mesylate, the patient exhibited a clinical response with grade 3 neutropenia, when pulmonary tuberculosis developed.
  • A c-kit mutation in exon 11 was detected only in metastatic liver specimens.
  • It is unclear whether or not pulmonary tuberculosis may be induced by imatinib mesylate treatment, but caution is warranted in immunocompromised GIST patients.
  • This is the first report of tuberculosis associated with neutropenia during imatinib mesylate treatment.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Gastrointestinal Stromal Tumors / complications. Jejunal Neoplasms / complications. Leiomyosarcoma / complications. Piperazines / adverse effects. Pyrimidines / adverse effects. Tuberculosis, Pulmonary / complications
  • [MeSH-minor] Administration, Oral. Antitubercular Agents / therapeutic use. Benzamides. Combined Modality Therapy. Digestive System Surgical Procedures. Fatal Outcome. Humans. Imatinib Mesylate. Laparotomy. Liver Neoplasms / diagnosis. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Male. Middle Aged. Neutropenia / chemically induced. Neutropenia / complications. Tomography, X-Ray Computed

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  • (PMID = 15750270.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antitubercular Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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5. Liang X, Xiao-Min S, Jiang-Ping X, Jie-Yu Y, Xiao-Jun Z, Zhi-Ren F, Guo-Shan D, Rui-Dong L: Liver transplantation for primary hepatic leiomyosarcoma: a case report and review of the literatures. Med Oncol; 2010 Dec;27(4):1269-72
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  • [Title] Liver transplantation for primary hepatic leiomyosarcoma: a case report and review of the literatures.
  • Primary hepatic leiomyosarcoma (PHL), a malignant mesenchymal tumor of myogenic origin, is exceedingly rare.
  • Patients may be afflicted with a wide spectrum of nonspecific symptoms, and most of the laboratory data are unhelpful to diagnosis.
  • Here, we report a 44-year-old woman with anorexia and right upper quadrant pain who was diagnosed as having malignant hepatic tumor within the Milan criteria and treated by orthotopic liver transplantation (OLT), the pathologic diagnosis of PHL was made by postoperative immunohistochemical study.
  • She underwent six courses of intravenous chemotherapy and enjoyed a 14-month tumor recurrence-free survival until the lymph node metastasis was detected, then we switched the tacrolimus to sirolimus and the patient survived for 20 months additionally.
  • The diagnostic and therapeutic features of PHL are also discussed by reviewing the literatures.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Immunosuppressive Agents / therapeutic use. Leiomyosarcoma / therapy. Liver Transplantation
  • [MeSH-minor] Adult. Combined Modality Therapy. Fatal Outcome. Female. Humans. Lymphatic Metastasis. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 19997990.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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6. Marcheix B, Dambrin C, Muscari F, Joseph-Hein K, Guimbaud R, Otal P: [Leiomyosarcoma of the inferior vena cava]. J Chir (Paris); 2003 Jun;140(3):140-8
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  • [Title] [Leiomyosarcoma of the inferior vena cava].
  • Leiomyosarcoma of the inferior vena cava is a rare tumor of mesenchymal origin most commonly found in women.
  • Imagery with ultrasound, CT, or MRI may strongly suggest the diagnosis, but it can only be confirmed by histologic examination of tissue obtained pre or intra-operatively.
  • Radical surgical resection is the only treatment which offers any hope for prolonged survival.
  • Progress in the techniques of hepatectomy and liver transplantation have allowed the experienced surgeon to undertake the removal of retrohepatic lesions once considered unresectable.
  • High-lying lesions adjacent to the hepatic veins or with thrombus extending into the proximal vena cava may require extracorporeal circulation with or without profound hypothermic circulatory arrest.
  • The efficacy of chemotherapy, whether pre-operative for inaccessible tumors or post-operative for incompletely resected or recurrent tumor, is poorly defined and very limited.
  • [MeSH-major] Leiomyosarcoma. Vascular Neoplasms. Vena Cava, Inferior
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 12910211.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 48
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7. Ueda T, Emoto M, Fukuoka M, Miyahara D, Horiuchi S, Tsujioka H, Kawarabayashi T: Primary leiomyosarcoma of the fallopian tube. Int J Clin Oncol; 2010 Apr;15(2):206-9
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  • [Title] Primary leiomyosarcoma of the fallopian tube.
  • We report the case of a 69-year-old woman affected with leiomyosarcoma of the left fallopian tube.
  • The preoperative diagnosis was a left adnexal malignant tumor based on pelvic examination, abdominal computed tomography, and magnetic resonance imaging.
  • Following a laparotomy, she was ultimately diagnosed with a FIGO IIc fallopian tube leiomyosarcoma.
  • The patient subsequently received adjuvant chemotherapy with pirarubicin and ifosfamide.
  • Thirty months after the first therapy, a computed tomography scan revealed metastasis of the liver, lung, and supraclavicular lymph node.
  • The patient died of the disease 39 months after the initial treatment.
  • [MeSH-major] Fallopian Tube Neoplasms / diagnosis. Leiomyosarcoma / diagnosis
  • [MeSH-minor] Aged. Biopsy. Chemotherapy, Adjuvant. Fatal Outcome. Female. Humans. Hysterectomy. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Magnetic Resonance Imaging. Omentum / surgery. Ovariectomy. Rectum / pathology. Rectum / surgery. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20191300.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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8. Lujan MG, Hoang MP: Pleomorphic leiomyosarcoma of the adrenal gland. Arch Pathol Lab Med; 2003 Jan;127(1):e32-5
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  • [Title] Pleomorphic leiomyosarcoma of the adrenal gland.
  • We present the clinical, morphologic, and immunohistochemical features of a pleomorphic leiomyosarcoma, a variant of leiomyosarcoma that has not been described in the adrenal gland.
  • A diagnosis of metastatic pulmonary carcinoma to the adrenal gland was rendered on a needle biopsy specimen.
  • Preoperative chemotherapy reduced only the pulmonary mass but not the adrenal mass, which continued to enlarge.
  • Documented by computed tomography and confirmed at surgery, the tumor had completely replaced the right adrenal gland, invading into both the posterior aspect of the right liver and the superior pole of the right kidney.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Leiomyosarcoma / pathology

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  • (PMID = 12562292.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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9. Nicòtina PA, Antico F, Caruso C, Triolo O: Primary ovarian leiomyosarcoma. Proliferation rate and survival. Eur J Gynaecol Oncol; 2004;25(4):515-6
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  • [Title] Primary ovarian leiomyosarcoma. Proliferation rate and survival.
  • OBJECTIVE: A case of Stage IIA primary ovarian leiomyosarcoma (LMS) with an unfavorable outcome 24 months after total abdominal hysterectomy with bilateral salpingo-oophorectomy, despite chemotherapy treatment, is described.
  • Eighteen months from surgery the patient showed peritoneal spreading with ascites, liver and lung metastases.
  • Immunohistology was also carried out to reveal some intermediate-type filamentous proteins, as histogenetic markers, and the MIB1 monoclonal antibody was used to assess the percent of MIB1-positive nuclei (MIB1 labeling index).
  • RESULTS: The histologic findings and immunohistology of the assayed intermediate filamentous proteins substantiated a diagnosis of LMS, with associated coagulation necrosis and not rare mitotic figures.
  • [MeSH-major] Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Neoplasm Invasiveness / pathology. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery

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  • (PMID = 15285319.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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10. Koga T, Kusumoto T, Kakeji Y, Kishikawa K, Maehara Y, Yonemura T, Irie K, Sugimachi K: Leiomyosarcoma of the greater omentum with liver metastasis: report of a case. Surg Today; 2002;32(5):434-8
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  • [Title] Leiomyosarcoma of the greater omentum with liver metastasis: report of a case.
  • We report herein a rare case of leiomyosarcoma arising from the greater omentum with concomitant liver metastases.
  • The findings of several examinations led us to suspect an omental leiomyosarcoma.
  • A laparotomy revealed an elastic hard and foliaceous mass (12.5 x 9.0 x 8.0 cm) arising from the omentum, and six masses in the liver.
  • The omental tumor was extirpated and chemotherapy was administered under the guidance of angiography.
  • The final diagnosis was leiomyosarcoma of the omentum.
  • About 9 months after the operation, multiple liver metastases were found and repeated chemotherapy was given, but without effect.
  • A partial hepatectomy was done, accompanied by microwave coagulation therapy (MCT).
  • Thus, surgical resection and MCT were effective against liver metastases of a leiomyosarcoma in this patient.
  • [MeSH-major] Leiomyosarcoma / secondary. Liver Neoplasms / secondary. Omentum. Peritoneal Neoplasms / pathology

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  • (PMID = 12061696.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 31
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11. Wrede J, Völcker HE, Dithmar S: [Subcutaneous leiomyosarcoma metastatic to the eyelid]. Ophthalmologe; 2007 Jan;104(1):66-8
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  • [Title] [Subcutaneous leiomyosarcoma metastatic to the eyelid].
  • Leiomyosarcomas are soft tissue sarcomas arising most commonly in the uterus and gastrointestinal tract, whereas dermal leiomyosarcomas are less frequent.
  • A subcutaneous leiomyosarcoma of the neck had been excised 21 months before with subsequent radiotherapy.
  • Seven months later metastases to the lung, liver, and left upper arm were detected.
  • The patient received chemotherapy.
  • The prognosis of cutaneous/subcutaneous leiomyosarcoma correlates with the depth of the tumor.
  • To our knowledge this is the first presentation of a subcutaneous leiomyosarcoma metastatic to the eyelid.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Eyelid Neoplasms / secondary. Leiomyosarcoma / diagnosis. Leiomyosarcoma / secondary. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Female. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / surgery. Humans. Treatment Outcome

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  • [Cites] Ophthalmology. 1991 Oct;98(10):1560-4 [1961645.001]
  • (PMID = 16132990.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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12. Sokolich J, Mejia A, Cheng S, Dunn E: Retroperitoneal leiomyosarcoma of the inferior vena cava mimicking a liver tumor. Am Surg; 2008 May;74(5):433-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal leiomyosarcoma of the inferior vena cava mimicking a liver tumor.
  • Leiomyosarcoma of the inferior vena cava (IVC) is a rare sarcoma, but it is the most common primary malignancy of the IVC.
  • Initial work-up including sonography, computed tomography, and magnetic resonance showed a tumor in the right upper quadrant of the abdominal cavity originating from the liver with compression of the IVC and displacement of the right kidney.
  • Postoperatively, she was placed on Coumadin and adjuvant chemotherapy was started.
  • Subsequently, the patient developed metastasis into the liver and peripancreatic nodes during the follow-up period.
  • [MeSH-major] Leiomyosarcoma / diagnosis. Liver Neoplasms / diagnosis. Retroperitoneal Neoplasms / diagnosis. Vascular Neoplasms / diagnosis. Vena Cava, Inferior / pathology
  • [MeSH-minor] Biopsy. Blood Vessel Prosthesis Implantation. Chemotherapy, Adjuvant. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Laparotomy. Lymphatic Metastasis / pathology. Middle Aged

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  • (PMID = 18481503.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Khabir A, Boudawara T, Ayadi L, Kharrat M, Kharrat M, Beyrouti I, Jlidi R: [Epithelioid bilateral ovarian leiomyosarcoma: a study]. Ann Pathol; 2003 Feb;23(1):47-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Epithelioid bilateral ovarian leiomyosarcoma: a study].
  • [Transliterated title] Léiomyosarcome ovarien bilatéral de type épithélioïde: une observation.
  • Primary ovarian leiomyosarcoma is extremely rare and generally affects post menopausal women.
  • Its histogenesis is not clear its prognosis seems to be improved by radical surgery and adjuvant therapy.
  • A diagnosis of bilateral ovarian epithelioid leiomyosarcoma was made on pathological examination with immunohistochemistry.
  • Adjuvant chemotherapy was given.
  • After 3 months of follow up, abdominal sonography revealed a peritoneal recurrent tumor with hepatic metastasis.
  • [MeSH-major] Leiomyosarcoma / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Fallopian Tubes / surgery. Female. Humans. Hysterectomy. Immunohistochemistry. Liver Neoplasms / secondary. Liver Neoplasms / ultrasonography. Menopause. Middle Aged. Ovariectomy. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 12743499.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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14. Steinert DM, Blakely LJ, Patel SR, Burgess MA, Chen LL, Trent JC, Raymond AK, Benjamin RS: Outcomes of gastrointestinal stromal tumors (GIST) and other intra-abdominal sarcomas (IAS) in the era of imatinib therapy. J Clin Oncol; 2004 Jul 15;22(14_suppl):9047

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes of gastrointestinal stromal tumors (GIST) and other intra-abdominal sarcomas (IAS) in the era of imatinib therapy.
  • In the era of kit immunohistochemistry and imatinib mesylate therapy the outcome of IASs is unknown.
  • METHODS: We analyzed 268 consecutive patients who were referred to our institution for evaluation of the diagnosis of GIST from 12/15/00 to 9/1/01.
  • Patients diagnosed with GIST were treated with imatinib mesylate, and patients diagnosed with other IAS were treated with standard sarcoma chemotherapy.
  • Another 46 patients were excluded because no data were available at the time of this abstract.
  • Of the remaining 218 patients, 159 (72.9%) were GIST and 59 (27.1%) were IAS specifically: 31 leiomyosarcoma, 10 spindle cell tumors, 4 unclassified sarcomas, and 14 other types of sarcoma.
  • The most common metastatic sites seen in patients with GIST were liver (68.6%) and peritoneum (51.6%); whereas other IASs metastasized to the liver (39%) and peritoneum (30.5%).
  • While median survival from the time of diagnosis has not been reached in patients with GIST, in other IAS median survival is 63.8 months.
  • Time to progression in patients with GIST was 16.4 months after imatinib and 5.1 months in patients with IAS treated with standard sarcoma chemotherapy.
  • CONCLUSIONS: Survival and time to progression are worse for IAS compared to GISTs.
  • New therapies for these tumors are needed.

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  • (PMID = 28014121.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Penel N, Italiano A, Isambert N, Bompas E, Bousquet G, Bousquet G, Duffaud F: Effect of metastasectomy and doxorubicin dose on the outcome of patients with metastastic leiomyosarcoma: A multicenter study. J Clin Oncol; 2009 May 20;27(15_suppl):10580

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of metastasectomy and doxorubicin dose on the outcome of patients with metastastic leiomyosarcoma: A multicenter study.
  • : 10580 Background: The role of metastasectomy and front-line chemotherapy modalities remain debated in the metastastatic soft tissue sarcoma setting.
  • The respective impact of treatment modalities on PFS and OS were assessed after adjustment to prognostic factors.
  • RESULTS: This database included 46 (31%) uterus and 101 soft-tissues (69%) M-LMS.
  • After front-line chemotherapy, 36 patients with lung metastasis (24%) underwent subsequent complete metastasectomy.
  • The univariate analysis identified the following prognostic factors for PFS: performance status (PS), grade, presence of liver or lung metastases.
  • Only one treatment parameter was associated with better PFS: planned doxorubicin dose superior to 60 mg/m<sup>2</sup>/3 weeks (HR=7.57 [1.32-10.40], p=0.023).
  • The univariate analysis identified the following prognostic factors: PS, time interval between diagnosis and metastatic relapse, local relapse and grade.
  • Under multivariate analysis, there was only one good prognostic factor for PFS: interval time between initial diagnosis and metastasis > 12 months (p=0.006).
  • Other chemotherapy parameters did not significantly modify OS.
  • CONCLUSIONS: Doxorubicin dose and metastasectomy remain the cornerstone of the optimal treatment of M-LMS.

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  • (PMID = 27963870.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Murakami M, Tsukada H, Ikeda M, Watanabe M, Muramatsu T, Miyamoto T, Makino T, Yasuda S, Ide M, Nasu S: Availability of whole-body positron emission tomography (PET) for the detection of metastatic sites in recurrent uterine sarcoma. J Clin Oncol; 2004 Jul 15;22(14_suppl):5100

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Availability of whole-body positron emission tomography (PET) for the detection of metastatic sites in recurrent uterine sarcoma.
  • Accurate diagnosis of the metastatic sites is important for the treatment strategy.
  • Unfortunately current diagnostic techniques, including CT, MRI, and ultrasonography (US) are not efficient for the detection of recurrence.
  • There is little report of the experience with whole-body 18 fluorodeoxyglucose (FDG)-PET for the detection of recurrence in the follow up of patients with uterine sarcomas.
  • The purpose of this study is to evaluate the availability of FDG-PET for the detection of recurrence in patients with uterine sarcomas.
  • METHODS: Twelve patients with pathologically proven uterine sarcomas (nine leiomyosarcoma and three carcinosarcoma) took FDG-PET, CT, MRI and US for the purpose of the detection of recurrence after the primary treatment.
  • RESULTS: The final diagnoses of recurrence were established in five cases (three carcinosarcoma and two leiomyosarcoma).
  • PET scan showed all recurrent sites of intraperitoneum, liver, lung and retroperitoneal lymph nodes.
  • Positive results of PET scan did not affect the prognosis in four patients, but another patient with solitary intraperitoneal tumor by PET scan could received the chemotherapy and operation, which histologically confirmed the recurrence of leiomyosarcoma.
  • Application of PET scan for the early detection of recurrence may affect the prognosis of some patients with uterine sarcoma.

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  • (PMID = 28015696.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Kanamori M, Ohmori K, Nogami S, Maeda Y: Undifferentiated leiomyosarcoma showing various sarcomatous components with incidental B-cell lymphoma after tumor recurrence. J Orthop Sci; 2002;7(6):698-702
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  • [Title] Undifferentiated leiomyosarcoma showing various sarcomatous components with incidental B-cell lymphoma after tumor recurrence.
  • We report a rare case of undifferentiated leiomyosarcoma (LMS) with incidental B-cell lymphoma in a 70-year-old woman.
  • The pathological diagnosis of repeated surgery was undifferentiated LMS that included various sarcomatous components, such as fibrosarcomatous, rhabdomyosarcomatous, and malignant fibrous histiocytoma-like elements.
  • A specimen from a supraclavicular lymph node showed the characteristics of malignant B-cell lymphoma (follicle type).
  • Adjuvant chemotherapy or radiation therapy was not performed because of the patient's advanced age.
  • The patient died from liver metastasis and dysfunction 5 years 8 months after the initial therapy.
  • Considerable debate remains whether the B-cell lymphoma developed incidentally.
  • [MeSH-major] Leiomyosarcoma / pathology. Lymphoma, B-Cell / pathology. Muscle Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 12486476.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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18. Liang SX, Lakshmanan Y, Woda BA, Jiang Z: A high-grade primary leiomyosarcoma of the bladder in a survivor of retinoblastoma. Arch Pathol Lab Med; 2001 Sep;125(9):1231-4
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  • [Title] A high-grade primary leiomyosarcoma of the bladder in a survivor of retinoblastoma.
  • Osteosarcoma is by far the most common type with an incidence of up to 50%, followed by soft tissue sarcomas.
  • Visceral leiomyosarcoma is extremely rare and only 2 cases have been reported in the past 2 decades, one in the liver and another one in the urinary bladder, both of which developed after cyclophosphamide therapy.
  • Here we report a case of vesical leiomyosarcoma that was diagnosed in a 49-year-old woman 47 years after the diagnosis of a hereditary retinoblastoma.
  • The patient's retinoblastoma was treated with unilateral enucleation without adjuvant radiation or chemotherapy.
  • We believe that this is the first report of vesical leiomyosarcoma occurring in a patient with retinoblastoma without a prior history of radiation or chemotherapy.
  • This report is significant not only because of the rarity of vesical leiomyosarcoma as a second nonocular tumor in retinoblastoma patients, but also because of the infrequency of vesical leiomyosarcoma in general.
  • We also investigated the potential molecular pathogenesis of the leiomyosarcoma.
  • [MeSH-major] Eye Neoplasms / surgery. Leiomyosarcoma / pathology. Neoplasms, Second Primary / pathology. Retinoblastoma / surgery. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adult. Cyclin D1 / analysis. Cystectomy. Desmin / analysis. Female. Hematuria / etiology. Humans. Hysterectomy. Ovariectomy. Retinoblastoma Protein / analysis. Survivors. Tomography, X-Ray Computed. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 11520280.001).
  • [ISSN] 0003-9985
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1
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19. Danikas D, Theodorou SJ, Singh R, Camal DE: Leiomyosarcoma of the gallbladder: a case report. Am Surg; 2001 Sep;67(9):873-4
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  • [Title] Leiomyosarcoma of the gallbladder: a case report.
  • The diagnosis is rarely made preoperatively.
  • Laparoscopic cholecystectomy was converted to open as a result of dense tissue in the middle to distal gallbladder.
  • Exploration by a right subcostal incision revealed multiple implants on the surface of the liver and the peritoneum of the upper abdomen.
  • Cholecystectomy with liver biopsy was performed.
  • Pathology revealed poorly differentiated epithelioid leiomyosarcoma of the gallbladder with extension to the liver.
  • The disease followed a very aggressive course and the patient died 3 weeks after the procedure.
  • Recommended treatment is extensive surgical resection that can be followed by radiotherapy or chemotherapy.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Leiomyosarcoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Gallbladder / pathology. Humans. Liver / pathology. Middle Aged

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  • (PMID = 11565767.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Jacobs VR, Zemzoum I, Kremer M, Gottschalk N, Baumgärtner AK, Krol J, Kiechle M: Primary metastatic leiomyosarcoma of the fallopian tube: a rare case report. Onkologie; 2010;33(1-2):49-52
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  • [Title] Primary metastatic leiomyosarcoma of the fallopian tube: a rare case report.
  • BACKGROUND: Leiomyosarcoma of the fallopian tube is an extremely unusual gynecologic neoplasm.
  • As such, clinical diagnosis and therapy management are difficult.
  • CASE REPORT: We report on the case of a 59-year-old woman with leiomyosarcoma of the fallopian tube and liver metastases at the time of diagnosis.
  • After initial tumor debulking, she received palliative chemotherapy with gemcitabine 900 mg/m(2) (d1+8) and docetaxel 100 mg/m(2) (d8) (q21).
  • After 2 cycles of chemotherapy, the disease progressed, and the patient died within 8 months of diagnosis.
  • CONCLUSIONS: Primary metastatic leiomyosarcoma of the fallopian tube is a progressive disease with limited therapy options.
  • [MeSH-major] Fallopian Tube Neoplasms / diagnosis. Leiomyosarcoma / secondary. Liver Neoplasms / secondary. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Combined Modality Therapy. Diagnostic Imaging. Disease Progression. Fallopian Tubes / pathology. Fatal Outcome. Female. Humans. Liver / pathology. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Palliative Care. Prognosis

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  • [Copyright] (c) 2010 S. Karger AG, Basel.
  • (PMID = 20164662.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 16
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21. Zhang H, Kong Y, Zhang H, He X, Zhang HY, Liu C, Xiao M, Xu X: Leiomyosarcoma of the inferior vena cava: case report and treatment of recurrence with repeat surgery. Ann Vasc Surg; 2010 Apr;24(3):417.e5-9
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  • [Title] Leiomyosarcoma of the inferior vena cava: case report and treatment of recurrence with repeat surgery.
  • Leiomyosarcoma of the inferior vena cava (IVC) is an extremely rare malignancy with poor prognosis due to late diagnosis.
  • Surgical resection currently remains the best treatment; however, recurrence frequently occurs and the 5-year survival rate is only 31%.
  • The aim of this study is to report a case of IVC leiomyosarcoma and treatment of recurrence with repeat surgery.
  • A 36-year-old woman with a high-grade leiomyosarcoma originating from the infrahepatic IVC underwent an en bloc excision of the tumor.
  • Since the patient showed no response to adjuvant chemotherapy (i.e., a combination of 5-fluorouracil and gemcitabine), repeat operations were used as the main treatment modality for recurrence.
  • The median time to recurrence was 15 months (range 8-27).
  • The middle and upper IVC segments were involved in the local recurrence, and metastatic lesions occurred in multiple sites including the stomach, omentum, mesentery, left liver, and pelvic cavity.
  • Our results suggest that in the setting of chemotherapy-refractory IVC leiomyosarcoma repeat surgery may be an alternative treatment for recurrence and improve survival time.
  • [MeSH-major] Abdominal Neoplasms / surgery. Digestive System Surgical Procedures. Leiomyosarcoma / surgery. Neoplasm Recurrence, Local. Pelvic Neoplasms / surgery. Vascular Neoplasms / surgery. Vascular Surgical Procedures. Vena Cava, Inferior / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Drug Resistance, Neoplasm. Female. Humans. Reoperation. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright (c) 2010 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20036495.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Swann HM, Holt DE: Canine gastric adenocarcinoma and leiomyosarcoma: a retrospective study of 21 cases (1986-1999) and literature review. J Am Anim Hosp Assoc; 2002 Mar-Apr;38(2):157-64
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  • [Title] Canine gastric adenocarcinoma and leiomyosarcoma: a retrospective study of 21 cases (1986-1999) and literature review.
  • This retrospective study describes the clinical course, treatment, and outcome of 21 dogs with gastric adenocarcinomas (n=19) and leiomyosarcomas (n=2).
  • Medical records from 1986 to 1999 were reviewed for signalment, weight, diagnosis, tumor location, clinical signs, radiographic imaging procedures, surgical procedures, chemotherapy, duration of follow-up monitoring, outcome, cause of death, metastatic rate, metastatic sites, and method of detection of metastasis.
  • Metastatic sites included gastric lymph nodes, omentum, liver, duodenum, pancreas, spleen, esophagus, adrenal glands, and lungs.
  • Both cases of a gastric leiomyosarcoma had metastatic disease involving the liver (n=2) and duodenum (n=1).
  • The beneficial effects of chemotherapy alone or adjuvant chemotherapy are still unknown.
  • [MeSH-major] Adenocarcinoma / veterinary. Dog Diseases / epidemiology. Leiomyosarcoma / veterinary. Stomach Neoplasms / veterinary
  • [MeSH-minor] Animals. Antineoplastic Agents / therapeutic use. Dogs. Female. Male. Neoplasm Metastasis. Pennsylvania / epidemiology. Records as Topic / veterinary. Retrospective Studies

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  • (PMID = 11908834.001).
  • [ISSN] 0587-2871
  • [Journal-full-title] Journal of the American Animal Hospital Association
  • [ISO-abbreviation] J Am Anim Hosp Assoc
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 22
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23. Al-Rikabi A, Hussain AA, Buchler M, Al-Muzrakchi A, Jyothi CR: Primary leiomyosarcoma of the inferior vena cava: report of a case diagnosed by fine needle aspiration cytology and confirmed by histopathologic examination. Acta Cytol; 2007 May-Jun;51(3):477-9
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  • [Title] Primary leiomyosarcoma of the inferior vena cava: report of a case diagnosed by fine needle aspiration cytology and confirmed by histopathologic examination.
  • BACKGROUND: Leiomyosarcoma is a malignant neoplasm and can originate within major abdominal veins, including the inferior venacava (IVC).
  • CASE: A 45-year-old woman presented with upper abdominal pain and a mass lesion in the liver and within the lumen of the IVC.
  • A diagnosis of primary leiomyosarcoma of the IVC was made by using imaging techniques,fine needle aspiration cytology and histopathologic examination of the resected specimen.
  • CONCLUSION: In patients presenting with vague upper abdominal pain and radiologic features of a hepatic mass extending to major veins, the rare possibility of primary leiomyosarcoma of the IVC shoald he considered and investigated by both fine needle aspiration cytology and intraoperative histology.
  • Early surgical intervention and/or postoperative chemotherapy and radiotherapy are associated with improved survival.
  • [MeSH-major] Leiomyosarcoma / pathology. Vascular Neoplasms / pathology. Vena Cava, Inferior / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Female. Humans. Middle Aged. Preoperative Care. Tomography, X-Ray Computed

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  • (PMID = 17536560.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Sandruck J, Escobar P, Lurain J, Fishman D: Uterine leiomyosarcoma metastatic to the sphenoid sinus: a case report and review of the literature. Gynecol Oncol; 2004 Feb;92(2):701-4
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  • [Title] Uterine leiomyosarcoma metastatic to the sphenoid sinus: a case report and review of the literature.
  • BACKGROUND: Leiomyosarcoma (LMS) of the uterus is a rare neoplasm with an aggressive growth pattern.
  • The most common sites of recurrent disease are lung, liver, and peritoneal cavity.
  • CASE: A 39-year-old woman underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic and paraaortic lymph node biopsies, omentectomy, and appendectomy for Grade 2 FIGO Stage 1 uterine leiomyosarcoma.
  • She underwent incomplete resection of the recurrence and was treated postoperatively with adjuvant MAID chemotherapy with poor response.
  • Five months later, she was treated with radiation therapy to the base of the skull with no response.
  • She expired from the disease 13 months after the diagnosis of the recurrence.
  • The treatment options are limited.
  • Surgical management should be considered as uterine LMS has a low response to chemotherapy and surgical resection of LMS to sites such as lung and abdomen has been suggested to offer a benefit.
  • Radiation therapy may provide palliative benefit in the setting of metastatic disease.
  • [MeSH-major] Leiomyosarcoma / pathology. Leiomyosarcoma / secondary. Paranasal Sinus Neoplasms / secondary. Sphenoid Sinus. Uterine Neoplasms / pathology

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  • (PMID = 14766270.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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25. Rajan DK, Soulen MC, Clark TW, Baum RA, Haskal ZJ, Shlansky-Goldberg RD, Freiman DB: Sarcomas metastatic to the liver: response and survival after cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol chemoembolization. J Vasc Interv Radiol; 2001 Feb;12(2):187-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sarcomas metastatic to the liver: response and survival after cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol chemoembolization.
  • PURPOSE: To evaluate the response to and survival after chemoembolization with cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol for patients with sarcomas metastatic to the liver that are surgically unresectable.
  • Primary tumors included 11 gastrointestinal leiomyosarcomas, two splenic angiosarcomas, one leiomyosarcoma of the broad ligament, one leiomyosarcoma of the inferior vena cava, and one malignant fibrous histiocytoma of the colon.
  • Chemoembolization with cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol particles was performed 1-5 times at approximately monthly intervals (mean, 2.8).
  • Pre- and posttreatment cross-sectional imaging was performed 1 month after completion of treatment and then every 3 months.
  • RESULTS: Two patients (13%) exhibited partial morphologic response, 11 patients (69%) were morphologically stable, and three (19%) demonstrated progression of disease 30 days after completion of treatment.
  • Among the 13 responders, two underwent partial hepatectomy after initial treatment.
  • Seven developed intrahepatic progression at a mean of 10 months and a median time of 8 months.
  • The remaining four patients had no documented intrahepatic progression at the time of last imaging follow-up.
  • Nine patients developed extrahepatic progression at a mean time of 6.3 months and a median time of 6 months, of whom four underwent additional surgical resection.
  • Response to therapy was based on time of first intervention.
  • Cumulative survival from time of diagnosis with use of Kaplan-Meier analysis was 81% at 1 year, 54% at 2 years, and 40% at 3 years.
  • Median survival time was 20 months.
  • Cumulative survival from initial chemoembolization was 67% at 1 year, 50% at 2 years, and 40% at 3 years, with a median survival time of 13 months.
  • CONCLUSION: Durable tumor response with chemoembolization is possible in this form of metastatic disease, which is highly resistant to systemic chemotherapy.
  • [MeSH-major] Chemoembolization, Therapeutic. Leiomyosarcoma / secondary. Leiomyosarcoma / therapy. Liver Neoplasms / secondary. Liver Neoplasms / therapy
  • [MeSH-minor] Cisplatin / administration & dosage. Disease Progression. Doxorubicin / administration & dosage. Ethiodized Oil / administration & dosage. Female. Follow-Up Studies. Humans. Male. Mitomycin / administration & dosage. Polyvinyl Alcohol / administration & dosage. Survival Rate. Time Factors

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  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • Hazardous Substances Data Bank. MITOMYCIN C .
  • Hazardous Substances Data Bank. Ethiodol .
  • Hazardous Substances Data Bank. POLYVINYL ALCOHOL .
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  • (PMID = 11265882.001).
  • [ISSN] 1051-0443
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 8008-53-5 / Ethiodized Oil; 80168379AG / Doxorubicin; 9002-89-5 / Polyvinyl Alcohol; Q20Q21Q62J / Cisplatin
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26. Serralta AS, Sanjuan FR, Moya AH, Orbis FC, López-Andújar R, Pareja EI, Vila JC, Rayón M, Juan MB, Mir JP: Combined liver transplantation plus imatinib for unresectable metastases of gastrointestinal stromal tumours. Eur J Gastroenterol Hepatol; 2004 Nov;16(11):1237-9
Hazardous Substances Data Bank. IMATINIB MESYLATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined liver transplantation plus imatinib for unresectable metastases of gastrointestinal stromal tumours.
  • Therapeutic options for treating unresectable hepatic metastases of leiomyosarcomas were scarce until a few years ago.
  • The introduction of imatinib (an antineoplasic drug that specifically acts on the pathogenesis of these tumours) has shown promising results in patients with advanced GISTs.
  • We present three patients with the initial diagnosis of unresectable hepatic metastases of leiomyosarcomas.
  • They received liver transplants.
  • Histological re-evaluation identified a stromal origin of the tumours, and the patients were treated with imatinib therapy (400 mg/day).
  • Recurrence occurred in all patients after a mean of 38.3 months, but imatinib treatment achieved control of the tumours.
  • The current survival times with the combination of transplantation and imatinib are 92, 48 and 46 months for the three patients.
  • This series is small and inconclusive, but imatinib treatment showed promising results.
  • The treatment options for patients with unresectable metastases of GISTs must be defined, as in these three patients liver transplantation achieved a disease-free status but all had tumour recurrences before starting the imatinib treatment.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Leiomyosarcoma / therapy. Liver Neoplasms / therapy. Liver Transplantation / methods. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Adult. Benzamides. Combined Modality Therapy / methods. Female. Humans. Imatinib Mesylate. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Treatment Outcome

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  • (PMID = 15489588.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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27. Almogy G, Lieberman S, Gips M, Pappo O, Edden Y, Jurim O, Simon Slasky B, Uzieli B, Eid A: Clinical outcomes of surgical resections for primary liver sarcoma in adults: results from a single centre. Eur J Surg Oncol; 2004 May;30(4):421-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical outcomes of surgical resections for primary liver sarcoma in adults: results from a single centre.
  • BACKGROUND: Primary hepatic sarcoma is a rare tumour with a poor prognosis.
  • METHODS: From 1997 to 2002 eight patients had liver resection for primary sarcoma of the liver at our institution.
  • The clinical characteristics, imaging findings, surgical procedures, adjuvant therapy and outcome were retrospectively reviewed.
  • There were two patients each with angiosarcoma (AS), leiomyosarcoma (LMS), and undifferentiated embryonal sarcoma (UES), one patient with epithelioid hemangioendothelioma (EHE) and one patient with malignant peripheral nerve sheath sarcoma (PNSS).
  • Preoperative diagnosis of a primary liver sarcoma was made in 7/8 cases, either by fine needle aspiration (n = 5) or angiography (n = 2).
  • Two patients developed complications and there was one death.
  • Systemic chemotherapy led to tumour regression in both patients with UES which enabled a second hepatic resection.
  • CONCLUSIONS: The majority of patients with primary liver sarcoma present with right upper quadrant pain, fever and a liver mass.
  • Differentiating the rare primary liver sarcoma from the much more common hepatocellular carcinoma (HCC) may aid in planning therapy.
  • Liver resection combined with adjuvant chemotherapy are the mainstays of treatment for UES in the adult.
  • [MeSH-major] Liver Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Diagnosis, Differential. Female. Hepatectomy / methods. Humans. Length of Stay. Liver Function Tests. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15063896.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Poggio JL, Nagorney DM, Nascimento AG, Rowland C, Kay P, Young RM, Donohue JH: Surgical treatment of adult primary hepatic sarcoma. Br J Surg; 2000 Nov;87(11):1500-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of adult primary hepatic sarcoma.
  • BACKGROUND: Primary sarcomas of the liver are extremely rare in adults.
  • Optimal therapeutic approaches remain unclear.
  • METHODS: Twenty consecutive adult patients who had surgical treatment for primary hepatic sarcomas were reviewed.
  • Other than one patient with primary hepatic angiosarcoma who had a history of thorium dioxide colloid (Thorotrast) exposure 23 years before diagnosis, no predisposing causes were apparent.
  • Nineteen patients had hepatic resection and one patient had an orthotopic liver transplant.
  • No patient received neoadjuvant chemotherapy or radiotherapy but radiotherapy was delivered intraoperatively in one patient.
  • RESULTS: Leiomyosarcoma was the most common histological type of sarcoma diagnosed (five of 20 patients), followed by malignant solitary fibrous tumour (four) and epithelioid haemangioendothelioma (three).
  • Thirteen patients developed a recurrence.
  • Distant metastases (ten patients) and intrahepatic recurrence (six) were the predominant sites of initial treatment failure.
  • Six patients received salvage chemotherapy.
  • CONCLUSION: Surgical resection is the only effective therapy for primary hepatic sarcomas at present.
  • Better adjuvant therapy is necessary, especially for high-grade malignancies, owing to the high failure rate with operation alone.
  • [MeSH-major] Liver Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Preoperative Care / methods. Retrospective Studies

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  • (PMID = 11091236.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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