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Items 1 to 27 of about 27
1. Sandhya B, Babu V, Parthasarathy G, Kate V, Ananthakrishnan N, Krishnan R: Primary leiomyosarcoma of the breast: A case report and review of literature. Indian J Surg; 2010 Jul;72(Suppl 1):286-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary leiomyosarcoma of the breast: A case report and review of literature.
  • We describe herein a case of primary leiomyosarcoma of the breast in a 54-year-old woman whose preoperative clinical and cytological findings indicated a benign breast tumour.
  • However, a core needle biopsy of the lesion showed malignant spindle cells without any ductal elements.
  • Histopathological examination of the mastectomy specimen suggested a diagnosis of leiomyosarcoma, which was subsequently confirmed by immunohistochemical analysis.
  • Primary leiomyosarcoma of the breast is very rare and is difficult to diagnose preoperatively as it needs immuno-histochemical staining.
  • The role of postoperative adjuvant chemotherapy is not well documented.

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  • (PMID = 23133273.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451846
  • [Keywords] NOTNLM ; Breast / Phyllodes Sandhya / Stromal tumours
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2. Agrawal V, Kumar S, Sharma D, Singh UR, Gupta A: Primary leiomyosarcoma of the seminal vesicle. Int J Urol; 2004 Apr;11(4):253-5
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  • [Title] Primary leiomyosarcoma of the seminal vesicle.
  • A case of leiomyosarcoma of the seminal vesicle detected as a prerectal mass on routine per-rectal examination is described in a 37-year-old man.
  • Computed tomography scan confirmed it to be arising from the right seminal vesicle.
  • Per-rectal trucut biopsy showed malignant cells.
  • Microscopic examination of the resected specimen showed moderately differentiated leiomyosarcoma from the seminal vesicle.
  • The patient received adjuvant chemotherapy and sandwiched radiotherapy.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Leiomyosarcoma / diagnosis. Seminal Vesicles / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Cystectomy. Humans. Lymph Node Excision. Male. Prostatectomy. Radiotherapy, Adjuvant

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  • (PMID = 15028108.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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3. Shirotake S, Sumitomo M, Asakuma J, Asano T, Aiko S, Hayakawa M: [A case of primary leiomyosarcoma of the ureter]. Hinyokika Kiyo; 2006 Jan;52(1):41-5
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  • [Title] [A case of primary leiomyosarcoma of the ureter].
  • Left nephroureterectomy and partial resection of the mesentery revealed a primary ureteral leiomyosarcoma.
  • Three months postoperatively, the patient received systemic chemotherapy (CYVADIC; cyclophosphamide, vincristine, adriamycin and DTIC) for a recurrent tumor.
  • Two courses of chemotherapy reduced the tumor by nearly 60%.
  • However, the tumor continued to progress and the patient died approximately one year after diagnosis.
  • [MeSH-major] Leiomyosarcoma / diagnosis. Ureteral Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Dacarbazine / administration & dosage. Doxorubicin / administration & dosage. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed. Vincristine / administration & dosage

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  • (PMID = 16479989.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; CYVADIC protocol
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4. Parissis H, Akbar MT, Young V: Primary leiomyosarcoma of the right atrium: a case report and literature update. J Cardiothorac Surg; 2010;5:80
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  • [Title] Primary leiomyosarcoma of the right atrium: a case report and literature update.
  • Leiomyosarcoma of the right atrium is a very rare cardiac tumor.
  • Various combinations of treatments including resection or transplant surgery and Chemotherapy have been advocated.
  • We report a case of a man who presented with pulmonary embolism secondary to right atrial leiomyosarcoma.
  • Postoperatively tumor dissemination was controlled with adjuvant chemotherapy.A vigorous attempt aiming at tumor clearance followed by adjuvant multimodality therapy along with a tumor surveillance program may improve survival.
  • [MeSH-major] Heart Neoplasms. Leiomyosarcoma

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  • (PMID = 20939891.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2964688
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5. Piovanello P, Viola V, Costa G, Carletti M, Cecera A, Turchetta F, Iudicone R, Catalano G, Santucci A, Recchia F, Fiorillo L, Menichella MA, Baiano G: Locally advanced leiomyosarcoma of the spleen. A case report and review of the literature. World J Surg Oncol; 2007;5:135

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  • [Title] Locally advanced leiomyosarcoma of the spleen. A case report and review of the literature.
  • Only one case of primary leiomyosarcoma of the spleen is described in human beings in literature.
  • CASE PRESENTATION: We report a case of locally advanced primary leiomyosarcoma of the spleen in a 54 year-old woman, diagnosed only after splenectomy, performed with the suspicion of splenic haematoma.
  • CONCLUSION: Due to the lack of cases, no specific chemotherapy regimen has been tested to provide a longer survival.

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  • (PMID = 18045454.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2221972
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6. Bodner-Adler B, Lozano P, Bodner K, Zeisler H: Primary uterine leiomyosarcoma and primary atypical meningioma diagnosed during pregnancy. Anticancer Res; 2008 Sep-Oct;28(5B):3083-5
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  • [Title] Primary uterine leiomyosarcoma and primary atypical meningioma diagnosed during pregnancy.
  • OBJECTIVE: Uterine leiomyosarcoma during pregnancy is an extremely rare event.
  • We report a case of both--a primary uterine leiomyosarcoma and additionally an atypical meningioma of the brain both diagnosed during pregnancy.
  • A tumoural mass was detected and initial conservative treatment was started.
  • Histopathological diagnosis of both tumours revealed an atypical meningioma of the brain and a uterine leiomyosarcoma.
  • The patient underwent laparatomy and received six cycles of adjuvant chemotherapy.
  • CONCLUSION: We are the first to report a case of a woman with two separate primary neoplasms both diagnosed during pregnancy.
  • Treatment options seem to be reduced in pregnant women and mainly depend on the patient's condition as well as the gestational age at presentation.
  • [MeSH-major] Brain Neoplasms / diagnosis. Leiomyosarcoma / diagnosis. Meningioma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Uterine Neoplasms / diagnosis


7. Duhan N, Singh S, Kadian YS, Duhan U, Rajotia N, Sangwan N: Primary leiomyosarcoma of broad ligament: case report and review of literature. Arch Gynecol Obstet; 2009 May;279(5):705-8
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  • [Title] Primary leiomyosarcoma of broad ligament: case report and review of literature.
  • INTRODUCTION: Primary leiomyosarcoma of the broad ligament (LBL) is a very rare and highly malignant gynecological tumor.
  • Treatment consisted of resection of the tumor along with omental and peritoneal sampling and adjuvant chemotherapy.
  • CONCLUSION: Complete surgery along with adjuvant chemotherapy or radiation and a close follow up for recurrence are advocated to optimize disease free survival.
  • [MeSH-major] Broad Ligament / pathology. Leiomyosarcoma / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Dactinomycin / administration & dosage. Female. Gynecologic Surgical Procedures. Humans. Middle Aged. Vincristine / administration & dosage

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  • (PMID = 18777035.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide
  • [Number-of-references] 27
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8. Jeanrot C, Ouaknine M, Anract P, Carlioz A, Forest M, Tomeno B: [Primary leiomyosarcoma of bone. Report of 5 anatomo-clinical cases and review of the literature]. Rev Chir Orthop Reparatrice Appar Mot; 2000 Feb;86(1):63-73
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  • [Title] [Primary leiomyosarcoma of bone. Report of 5 anatomo-clinical cases and review of the literature].
  • INTRODUCTION: Leiomyosarcoma is a malignant smooth muscle tumor occurring most frequently in uterus or soft tissues and more rarely in bone.
  • MATERIALS AND METHODS: We report the clinicopathologic, immunohistochemical and ultrastructural findings of five cases of primary leiomyosarcoma of bone treated in our Department between 1991 and 1994.
  • RESULTS: The tumors were located respectively in the distal tibia (n=2), the distal femur, the sternum and the ilium (n=1).
  • Two patients died of metastatic disease, two had local recurrence and one is alive with no evidence of disease at the last follow-up.
  • DISCUSSION: Excluding cases which involve the facial skeleton, there are to our knowledge 95 cases of primary leiomyosarcoma of bone reported in the literature.
  • The diagnosis is based on microscopic features demonstrating fusiform tumor cells arranged in interwoven bundles, and the immunohistochemical results of widespread cytoplasmic positivity for smooth muscle actin.
  • The best pronostic parameter is the histologic grade correlated with both the recurrence and metastatic rates as well as the survival rate.
  • Surgery constitutes the main treatment since chemotherapy or radiotherapy did not provide an improved prognosis over a wide resection.
  • [MeSH-major] Bone Neoplasms / diagnosis. Leiomyosarcoma / diagnosis

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  • (PMID = 10669826.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] FRANCE
  • [Number-of-references] 53
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9. Labanaris AP, Zugor V, Smiszek R, Nützel R, Kühn R: Primary leiomyosarcoma of the testis. A case report. Anticancer Res; 2010 May;30(5):1725-6
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  • [Title] Primary leiomyosarcoma of the testis. A case report.
  • Primary leiomyosarcoma of the testis is an extremely rare disease entity of the genito-urinary tract.
  • Diagnosis is achieved by combining histologic and immunohistochemical findings.
  • Although the number of reported cases is not significant and the clinical and biological behaviour of these tumors are very hard to predict, we demonstrate that radical orchidectomy followed by surveillance appears to be the treatment of choice.
  • Retroperitoneal lymphadenectomy, radiotherapy and chemotherapy do not seem to have any place in the treatment of this type of malignancy.
  • [MeSH-major] Leiomyosarcoma / diagnosis. Leiomyosarcoma / pathology. Testicular Neoplasms / diagnosis. Testicular Neoplasms / pathology

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  • (PMID = 20592368.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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10. Bodner K, Bodner-Adler B, Czerwenka K, Hudelist G, Kimberger O, Leodolter S, Mayerhofer K: Bcl-2 expression in a primary leiomyosarcoma of the ovary: a case report. Wien Klin Wochenschr; 2003 Mar 31;115(5-6):191-5
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  • [Title] Bcl-2 expression in a primary leiomyosarcoma of the ovary: a case report.
  • BACKGROUND: Primary ovarian leiomyosarcoma is an extremely rare malignant smooth-muscle neoplasm with fewer than 30 documented cases worldwide.
  • Until recently, no report investigated the role of bcl-2 expression in primary ovarian leiomyosarcoma.
  • We report the management and an immunohistochemical analysis of bcl-2 in a patient with primary leiomyosarcoma of the ovary.
  • Surgical exploration revealed a large left adnexal mass that had developed from the left ovary and infiltrated one part of the omentum adherent to the left adnexa.
  • According to the FIGO staging system for ovarian cancer, the tumor was classified as a primary ovarian leiomyosarcoma stage III C, and the patient was treated with an adjuvant chemotherapy regimen consisting of cisplatin and ifosfamide.
  • Two days after the third cycle of cisplatin/ifosfamid she developed an apoplexy spontaneously and chemotherapy was therefore discontinued.
  • CONCLUSIONS: Beside the routine histological and immunohistochemical characteristics of primary ovarian leiomyosarcoma, strong staining for bcl-2 was detected.
  • In order to understand more about the nature and the behaviour of this highly malignant neoplasm and to be able to improve the treatment, the prognostic value of bcl-2 has to be investigated in additional studies.
  • [MeSH-major] Leiomyosarcoma / pathology. Ovarian Neoplasms / pathology. Proto-Oncogene Proteins c-bcl-2 / analysis
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Fatal Outcome. Female. Humans. Ovariectomy. Ovary / pathology

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  • (PMID = 12741081.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2
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11. Al-Rikabi A, Hussain AA, Buchler M, Al-Muzrakchi A, Jyothi CR: Primary leiomyosarcoma of the inferior vena cava: report of a case diagnosed by fine needle aspiration cytology and confirmed by histopathologic examination. Acta Cytol; 2007 May-Jun;51(3):477-9
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  • [Title] Primary leiomyosarcoma of the inferior vena cava: report of a case diagnosed by fine needle aspiration cytology and confirmed by histopathologic examination.
  • BACKGROUND: Leiomyosarcoma is a malignant neoplasm and can originate within major abdominal veins, including the inferior venacava (IVC).
  • A diagnosis of primary leiomyosarcoma of the IVC was made by using imaging techniques,fine needle aspiration cytology and histopathologic examination of the resected specimen.
  • CONCLUSION: In patients presenting with vague upper abdominal pain and radiologic features of a hepatic mass extending to major veins, the rare possibility of primary leiomyosarcoma of the IVC shoald he considered and investigated by both fine needle aspiration cytology and intraoperative histology.
  • Early surgical intervention and/or postoperative chemotherapy and radiotherapy are associated with improved survival.
  • [MeSH-major] Leiomyosarcoma / pathology. Vascular Neoplasms / pathology. Vena Cava, Inferior / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Female. Humans. Middle Aged. Preoperative Care. Tomography, X-Ray Computed

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  • (PMID = 17536560.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Ueda T, Emoto M, Fukuoka M, Miyahara D, Horiuchi S, Tsujioka H, Kawarabayashi T: Primary leiomyosarcoma of the fallopian tube. Int J Clin Oncol; 2010 Apr;15(2):206-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary leiomyosarcoma of the fallopian tube.
  • Primary sarcoma of the fallopian tube is a very rare neoplasm.
  • We report the case of a 69-year-old woman affected with leiomyosarcoma of the left fallopian tube.
  • The preoperative diagnosis was a left adnexal malignant tumor based on pelvic examination, abdominal computed tomography, and magnetic resonance imaging.
  • Following a laparotomy, she was ultimately diagnosed with a FIGO IIc fallopian tube leiomyosarcoma.
  • The patient subsequently received adjuvant chemotherapy with pirarubicin and ifosfamide.
  • Thirty months after the first therapy, a computed tomography scan revealed metastasis of the liver, lung, and supraclavicular lymph node.
  • The patient died of the disease 39 months after the initial treatment.
  • [MeSH-major] Fallopian Tube Neoplasms / diagnosis. Leiomyosarcoma / diagnosis
  • [MeSH-minor] Aged. Biopsy. Chemotherapy, Adjuvant. Fatal Outcome. Female. Humans. Hysterectomy. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Magnetic Resonance Imaging. Omentum / surgery. Ovariectomy. Rectum / pathology. Rectum / surgery. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20191300.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Liang SX, Lakshmanan Y, Woda BA, Jiang Z: A high-grade primary leiomyosarcoma of the bladder in a survivor of retinoblastoma. Arch Pathol Lab Med; 2001 Sep;125(9):1231-4
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  • [Title] A high-grade primary leiomyosarcoma of the bladder in a survivor of retinoblastoma.
  • Osteosarcoma is by far the most common type with an incidence of up to 50%, followed by soft tissue sarcomas.
  • Visceral leiomyosarcoma is extremely rare and only 2 cases have been reported in the past 2 decades, one in the liver and another one in the urinary bladder, both of which developed after cyclophosphamide therapy.
  • Here we report a case of vesical leiomyosarcoma that was diagnosed in a 49-year-old woman 47 years after the diagnosis of a hereditary retinoblastoma.
  • The patient's retinoblastoma was treated with unilateral enucleation without adjuvant radiation or chemotherapy.
  • We believe that this is the first report of vesical leiomyosarcoma occurring in a patient with retinoblastoma without a prior history of radiation or chemotherapy.
  • This report is significant not only because of the rarity of vesical leiomyosarcoma as a second nonocular tumor in retinoblastoma patients, but also because of the infrequency of vesical leiomyosarcoma in general.
  • We also investigated the potential molecular pathogenesis of the leiomyosarcoma.
  • [MeSH-major] Eye Neoplasms / surgery. Leiomyosarcoma / pathology. Neoplasms, Second Primary / pathology. Retinoblastoma / surgery. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adult. Cyclin D1 / analysis. Cystectomy. Desmin / analysis. Female. Hematuria / etiology. Humans. Hysterectomy. Ovariectomy. Retinoblastoma Protein / analysis. Survivors. Tomography, X-Ray Computed. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 11520280.001).
  • [ISSN] 0003-9985
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1
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14. Lehman NL, Jacobs CD, Holsten PA, Jaikumar S, Lehman TD, Gibbs IC, Shuer LM: Primary paraspinal leiomyosarcoma invading the cervical spinal canal successfully treated with surgery, radiotherapy, and chemotherapy. Case report. J Neurosurg Spine; 2007 May;6(5):441-6
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  • [Title] Primary paraspinal leiomyosarcoma invading the cervical spinal canal successfully treated with surgery, radiotherapy, and chemotherapy. Case report.
  • A primary paraspinal leiomyosarcoma invading the spine is an exceedingly rare neoplasm that may clinically mimic a schwannoma.
  • The authors report a case involving a 45-year-old man with a primary leiomyosarcoma of the cervical paraspinal musculature that invaded the spinal canal at C1-2 and subsequently metastasized to the lungs and pancreas.
  • Aggressive treatment consisting of resection of the primary tumor, adjunctive radiation therapy and chemotherapy, and surgical debulking of metastatic disease resulted in local tumor control at the primary site and long-term survival of the patient.
  • [MeSH-major] Leiomyosarcoma / therapy. Spinal Neoplasms / therapy
  • [MeSH-minor] Cervical Vertebrae / pathology. Combined Modality Therapy. Humans. Male. Middle Aged. Neoplasm Invasiveness. Spinal Canal / pathology

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  • (PMID = 17542511.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS45077
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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15. Silvestris N, Piscitelli D, Crucitta E, Fiore M, De Lena M, Lorusso V: Unusual response to second-line single-agent gemcitabine in locally advanced primary leiomyosarcoma of the lung: a case report. J Chemother; 2003 Oct;15(5):507-9
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  • [Title] Unusual response to second-line single-agent gemcitabine in locally advanced primary leiomyosarcoma of the lung: a case report.
  • Primary leiomyosarcomas (LMSs) of the lung are extremely rare malignancies that have been the subject of single or small series of case reports.
  • Today, the gold standard of treatment in patients with locally advanced and metastatic disease includes one of the many possible regimens containing an anthracycline and/or ifosfamide.
  • Few chemotherapy agents are active in the second-line setting.
  • In particular, gemcitabine is considered quite ineffective in the treatment of first- as well as second-line chemotherapy of soft tissue sarcoma and responses to this agent are seldom reported.
  • In this paper, we report a single patient with primary LMS of the lung previously treated with a combination of epirubicin and ifosfamide.
  • The patient responded to second-line chemotherapy with gemcitabine 1250 mg/m2 given as a 30-minute infusion on days 1, 8, and 15 of a 28-day cycle and showed an 8-month response duration and negligible toxicity.
  • Gemcitabine may represent an alternative to the best supportive care in patients affected with soft tissue sarcoma who fail first-line chemotherapy.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Leiomyosarcoma / drug therapy. Lung Neoplasms / drug therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Drug Resistance, Neoplasm. Epirubicin / administration & dosage. Epirubicin / pharmacology. Humans. Ifosfamide / administration & dosage. Ifosfamide / pharmacology. Male. Middle Aged

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  • (PMID = 14603882.001).
  • [ISSN] 1120-009X
  • [Journal-full-title] Journal of chemotherapy (Florence, Italy)
  • [ISO-abbreviation] J Chemother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 3Z8479ZZ5X / Epirubicin; B76N6SBZ8R / gemcitabine; UM20QQM95Y / Ifosfamide
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16. Mariani L, Quattrini M, Galati M, Dionisi B, Piperno G, Modafferi F, Sbiroli C: Primary leiomyosarcoma of the fallopian tube: a case report. Eur J Gynaecol Oncol; 2005;26(3):333-5
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  • [Title] Primary leiomyosarcoma of the fallopian tube: a case report.
  • A primary leiomyosarcoma (LMS) arising from the left fallopian tube in a perimenopausal 48-year-old woman is reported.
  • Primary tubal LMS is an uncommon, exceedingly rare neoplasm, accounting for only a few reported cases so far.
  • The diagnosis is usually made at the time of laparotomy for a pelvic or adnexal mass or other gynaecological indications.
  • As in ovarian neoplasms, the mainstay of treatment is represented by debulking surgery consisting of total abdominal hysterectomy, bilateral salpingo-oophorectomy, random biopsies, peritoneal washing and excision of all the abdominal tumour masses.
  • The role of adjuvant radio- or chemotherapy still remains unsolved.
  • [MeSH-major] Fallopian Tube Neoplasms / diagnosis. Leiomyosarcoma / diagnosis
  • [MeSH-minor] Female. Gynecologic Surgical Procedures. Humans. Middle Aged. Treatment Outcome

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  • (PMID = 15991540.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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17. Kobayashi Y, Tozawa A, Okuma Y, Kiguchi K, Ishizuka B: Complete remission with intraperitoneal cisplatin followed by prolonged oral etoposide in a stage IIIc primary leiomyosarcoma of the fallopian tube patient. J Obstet Gynaecol Res; 2010 Aug;36(4):894-7
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  • [Title] Complete remission with intraperitoneal cisplatin followed by prolonged oral etoposide in a stage IIIc primary leiomyosarcoma of the fallopian tube patient.
  • Leiomyosarcoma (LMS) of the fallopian tube is exceedingly uncommon.
  • Because of elevated serum lactate dehydrogenase and CA125 as well as the findings of pelvic magnetic resonance imaging and computerized tomography, the patient was suspected to have ovarian cancer.
  • [MeSH-major] Cisplatin / therapeutic use. Etoposide / therapeutic use. Fallopian Tube Neoplasms / drug therapy. Leiomyosarcoma / drug therapy
  • [MeSH-minor] Aged. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols. Female. Humans. Injections, Intraperitoneal. Neoplasm Staging. Remission Induction. Treatment Outcome

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  • (PMID = 20666965.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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18. Kolusari A, Ugurluer G, Kosem M, Kurdoglu M, Yildizhan R, Adali E: Leiomyosarcoma of the broad ligament: a case report and review of the literature. Eur J Gynaecol Oncol; 2009;30(3):332-4
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  • [Title] Leiomyosarcoma of the broad ligament: a case report and review of the literature.
  • Leiomyosarcoma of the broad ligament is a rare tumour, since only 15 cases have been reported thus far in the English literature.
  • We describe the case of a 35-year-old patient with primary leiomyosarcoma of the broad ligament.
  • The histologic diagnosis and management of this rapidly progressive and highly malignant tumour are also discussed.
  • The treatment consisted of total abdominal hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection.
  • The patient received pelvic radiotherapy and chemotherapy considering the high grade of malignancy.
  • [MeSH-major] Broad Ligament. Genital Neoplasms, Female / diagnosis. Leiomyosarcoma / diagnosis
  • [MeSH-minor] Adnexal Diseases / diagnosis. Adnexal Diseases / pathology. Adult. Female. Humans

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  • (PMID = 19697635.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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19. Tomasich FD, Luz Mde A, Kato M, Targa GZ, Dias LA, Zucoloto FJ, Ogata DC: [Primary adrenal leiomyosarcoma]. Arq Bras Endocrinol Metabol; 2008 Dec;52(9):1510-4
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  • [Title] [Primary adrenal leiomyosarcoma].
  • Leiomyosarcoma of adrenal gland is an extremely rare tumor originating from the central adrenal vein or its tributaries.
  • In this paper we report a case of a 48 year-old woman whose diagnosis was made by image exams that had suggested a mass in adrenal area.
  • The histopathologic and immunohistochemistry exams were compatible with primary leiomyosarcoma of adrenal gland.
  • Despite of the rarity of this tumor, leiomyosarcoma of adrenal gland has an aggressive behavior, such as the others soft tissue sarcomas.
  • The adrenalectomy is the primary treatment, while chemotherapy or radiotherapy is not prescribed except in metastatic or bulky and inoperable disease.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Leiomyosarcoma / pathology

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  • (PMID = 19197462.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 13
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20. Mayerhofer K, Lozanov P, Bodner K, Bodner-Adler B, Mayerhofer-Gallenbacher N, Hudelist G, Czerwenka K: Immunohistochemical analysis of a primary ovarian leiomyosarcoma. Case report. Anticancer Res; 2003 Jul-Aug;23(4):3433-6
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  • [Title] Immunohistochemical analysis of a primary ovarian leiomyosarcoma. Case report.
  • BACKGROUND: Primary ovarian leiomyosarcoma is an extremely rare malignant smooth muscle neoplasm.
  • We report a case of a primary leiomyosarcoma of the ovary managed at our institution.
  • CASE REPORT: Surgical exploration in a 71-year-old woman revealed a large left adnexal tumor and one separate metastatic implant in one part of the omentum, being classified as a primary ovarian leiomyosarcoma stage III C.
  • The patient was treated with an adjuvant chemotherapy regimen consisting of cisplatin and ifosfamide.
  • CONCLUSION: Until recently, prognostic parameters in ovarian leiomyosarcoma have still not been identified.
  • [MeSH-major] Leiomyosarcoma / metabolism. Ovarian Neoplasms / metabolism

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  • (PMID = 12926085.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Endothelial Growth Factors; 0 / Intercellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 0 / Lymphokines; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factors; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.7 / Matrix Metalloproteinase 1
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21. Sahu L, Bupathy A, Badhe BA: Leiomyosarcoma of the uterine cervix in a young woman. J Obstet Gynaecol Res; 2008 Aug;34(4 Pt 2):717-20
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  • [Title] Leiomyosarcoma of the uterine cervix in a young woman.
  • Primary leiomyosarcoma of the uterine cervix is an exceedingly rare tumor.
  • Biopsy showed leiomyosarcoma.
  • Two cycles of chemotherapy with cisplatin, doxorubicin and cyclophosphamide were given and then a total hysterectomy with bilateral salpingo-oophorectomy was carried out, followed by local radiation to the anterior vaginal wall.
  • The patient developed extensive metastasis within 6 months of surgery.
  • Because the number of reported cases is very small, the optimal mode of treatment is yet to be established.
  • [MeSH-major] Leiomyosarcoma / diagnosis. Uterine Cervical Neoplasms / diagnosis

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  • (PMID = 18840189.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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22. Giuliante F, Sarno G, Ardito F, Pierconti F: Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge. Tumori; 2009 May-Jun;95(3):374-7
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  • [Title] Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge.
  • BACKGROUND: Primary leiomyosarcoma of the liver is a rare tumor whose development patterns are unsatisfactorily known.
  • PATIENT CASE: A 26-year-old male patient with a previous history of radiochemotherapy treatment for Hodgkin's lymphoma was referred to our unit with a histological and radiological diagnosis of primary hepatic leiomyosarcoma.
  • Shortly before referral the lesion had grown to 7.8 cm, associated with two smaller lesions in segments VIII and III, and a diagnosis of hepatic leiomyosarcoma was made at biopsy.
  • This was followed by rapid progression of the disease, in spite of transient stabilization under gemcitabine treatment.
  • Octreotide was also administered after the detection of elevated chromogranin A in serum.
  • CONCLUSIONS: The challenges and peculiarities of this case are related to the rarity of the tumor, its accidental discovery without immediate suspicion of its nature, its very aggressive behavior that was only partly controlled by chemotherapy, and the unusual expression of a neuroendocrine phenotypic feature with high serum chromogranin A levels.
  • [MeSH-major] Hodgkin Disease. Leiomyosarcoma. Liver Neoplasms. Neoplasms, Second Primary
  • [MeSH-minor] Adult. Fatal Outcome. Hepatectomy. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19688980.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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23. Kyriazi MA, Stafyla VK, Chatzinikolaou I, Koureas A, Chatziioannou A, Kondi-Paphiti A, Arkadopoulos N, Smyrniotis V: Surgical challenges in the treatment of leiomyosarcoma of the inferior vena cava: analysis of two cases and brief review of the literature. Ann Vasc Surg; 2010 Aug;24(6):826.e13-7
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  • [Title] Surgical challenges in the treatment of leiomyosarcoma of the inferior vena cava: analysis of two cases and brief review of the literature.
  • BACKGROUND: Leiomyosarcoma of the inferior vena cava (IVC) is a rare tumor of mesenchymal origin.
  • Optimal treatment should include complete resection of the malignant lesion with preservation of venous return.
  • METHODS AND RESULTS: The first case is that of a 54-year-old woman, with a 9 cm a primary IVC leiomyosarcoma extending from the level of the right renal vein to the common iliac veins.
  • She received adjuvant chemotherapy and is free of recurrence almost 3 years after surgery.
  • Pathological examination confirmed primary leiomyosarcoma of the IVC.
  • She received adjuvant chemotherapy, but was referred to our hospital with local recurrence 6 months after the operation and is suffering from disseminated abdominal disease almost a year postsurgery.
  • CONCLUSION: Radical surgical en bloc resection is the mainstay of treatment for IVC leiomyosarcomas.
  • [MeSH-major] Leiomyosarcoma / surgery. Vascular Neoplasms / surgery. Vascular Surgical Procedures. Vena Cava, Inferior / surgery
  • [MeSH-minor] Abdominal Pain / etiology. Back Pain / etiology. Chemotherapy, Adjuvant. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright 2010 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20471215.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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24. Tan GW, Chia KH: An unusual case of leiomyosarcoma of the inferior vena cava in a patient with a duplicated inferior vena cava. Ann Vasc Surg; 2009 Mar;23(2):256.e13-8
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  • [Title] An unusual case of leiomyosarcoma of the inferior vena cava in a patient with a duplicated inferior vena cava.
  • Leiomyosarcoma of primary vascular origin is a rare primary soft tissue tumour, which arises mainly from the inferior vena cava (IVC).
  • Complete surgical resection with clear surgical margin plays a central therapeutic role.
  • The effect of chemotherapy and radiation therapy remains to be evaluated.
  • We report a 64 year old Chinese female who presented with abdominal mass and pain associated with weight loss and was subsequently diagnosed with inferior vena cava leiomyosarcoma.
  • She underwent successful surgical resection but unfortunately developed recurrence of tumour 12 month post-operative.
  • We discuss the surgical treatment and results of leiomyosarcoma of the IVC.
  • [MeSH-major] Leiomyosarcoma / pathology. Vascular Neoplasms / pathology. Vena Cava, Inferior / abnormalities
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Reoperation. Tomography, X-Ray Computed. Treatment Outcome. Vascular Surgical Procedures

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  • (PMID = 18809279.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. El Husseiny G, Al Bareedy N, Mourad WA, Mohamed G, Shoukri M, Subhi J, Ezzat A: Prognostic factors and treatment modalities in uterine sarcoma. Am J Clin Oncol; 2002 Jun;25(3):256-60
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  • [Title] Prognostic factors and treatment modalities in uterine sarcoma.
  • Nine patients received adjuvant treatment; five had radiation therapy (XRT), two had chemotherapy, one had combined XRT and chemotherapy, and one received hormonal treatment.
  • Leiomyosarcoma cases accounted for 42% of all the uterine sarcomas, carcinosarcoma cases for 34%, and endometrial stromal sarcoma (ESS) for 24%.
  • Recurrences developed in 34 patients (71%).
  • The 5- and 10-year overall actuarial survival for all patients was 42%, and the corresponding relapse-free survivals for those who achieved complete response after primary treatment (48 patients) were 27% and 20%.
  • On the univariate analysis, grade I tumors (p = 0.04), ESS (p = 0.02), nonmetastatic stage (p = 0.05), and negative peritoneal cytology (p = 0.04) were associated with better overall survival.
  • [MeSH-major] Sarcoma / therapy. Uterine Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Female. Humans. Hysterectomy. Lymph Node Excision. Middle Aged. Multivariate Analysis. Ovariectomy. Prognosis. Radiotherapy Dosage. Survival Analysis

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  • (PMID = 12040283.001).
  • [ISSN] 0277-3732
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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26. Stoeckle E, Coindre JM, Bonvalot S, Kantor G, Terrier P, Bonichon F, Nguyen Bui B, French Federation of Cancer Centers Sarcoma Group: Prognostic factors in retroperitoneal sarcoma: a multivariate analysis of a series of 165 patients of the French Cancer Center Federation Sarcoma Group. Cancer; 2001 Jul 15;92(2):359-68
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  • However, despite progress, surgery alone is rarely curative, and analysis of the causes of failures and of other prognostic factors are warranted to ascertain treatment orientations.
  • METHODS: Data of patients treated from 1.80 to 12.94 for primary retroperitoneal sarcoma were extracted from the French Federation of Cancer Centers Sarcoma Group registry.
  • Liposarcoma, leiomyosarcoma, and malignant fibrous histiocytoma represented 66% of the tumors.
  • Multimodality treatment included surgery (150 patients), radiotherapy (92 patients), and chemotherapy (77 patients).
  • Complete excision was achieved in 94 of 145 nonmetastatic patients.
  • The main prognostic factors for survival were initial metastases and surgery, which represented the major treatment-linked factor.
  • High-grade of tumors affected local recurrence, metastatic recurrence, and survival.
  • [MeSH-major] Neoplasm Recurrence, Local. Retroperitoneal Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Radiotherapy, Adjuvant. Retrospective Studies. Risk Factors. Survival Analysis

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  • [Copyright] Copyright 2001 American Cancer Society.
  • (PMID = 11466691.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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27. Villalona-Calero MA, Eckhardt SG, Weiss G, Hidalgo M, Beijnen JH, van Kesteren C, Rosing H, Campbell E, Kraynak M, Lopez-Lazaro L, Guzman C, Von Hoff DD, Jimeno J, Rowinsky EK: A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies. Clin Cancer Res; 2002 Jan;8(1):75-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Antitumor activity was noted in three patients with leiomyosarcoma and primary peritoneal and ovarian carcinomas.
  • The pharmacokinetics of ET-743 were dose independent, and drug accumulation over the 5 days of treatment was modest, with the ratio of the area under the plasma-versus-time curve on day 5 to that on day 1 averaging 2.05.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Alanine Transaminase / metabolism. Area Under Curve. Aspartate Aminotransferases / metabolism. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Humans. Infusions, Intravenous. Liver / drug effects. Male. Maximum Tolerated Dose. Middle Aged. Tetrahydroisoquinolines. Time Factors. Tissue Distribution

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  • (PMID = 11801542.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR01346
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Dioxoles; 0 / Isoquinolines; 0 / Tetrahydroisoquinolines; 114899-77-3 / trabectedin; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
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