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1. Saif MW, Khubchandani S, Walczak M: Secondary pancreatic involvement by a diffuse large B-cell lymphoma presenting as acute pancreatitis. World J Gastroenterol; 2007 Sep 28;13(36):4909-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary pancreatic involvement by a diffuse large B-cell lymphoma presenting as acute pancreatitis.
  • Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma.
  • More than 50% of patients have some site of extra-nodal involvement at diagnosis, including the gastrointestinal tract and bone marrow.
  • However, a diffuse large B-cell lymphoma presenting as acute pancreatitis is rare.
  • She was admitted with a diagnosis of acute pancreatitis.
  • Abdominal computed tomography (CT) scan showed diffusely enlarged pancreas due to infiltrative neoplasm and peripancreatic lymphadenopathy.
  • Biopsy of the axillary mass revealed a large B-cell lymphoma.
  • The patient was classified as stage IV, based on the Ann Arbor Classification, and as having a high-risk lymphoma, based on the International Prognostic Index.
  • She was started on chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone).
  • Within a week after chemotherapy, the patient's abdominal pain resolved.
  • Follow-up CT scan of the abdomen revealed a marked decrease in the size of the pancreas and peripancreatic lymphadenopathy.
  • A literature search revealed only seven cases of primary involvement of the pancreas in B-cell lymphoma presenting as acute pancreatitis.
  • However, only one case of secondary pancreatic involvement by B-cell lymphoma presenting as acute pancreatitis has been published.
  • Both cases responded well to chemotherapy.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Pancreatic Neoplasms / diagnosis. Pancreatitis / etiology


2. Ahmed B, Estey E, Manning J, David C, Keating MJ, Kantarjian H, Tsimberidou AM: Anaplastic large cell lymphoma with involvement of the pancreas presenting as panniculitis in a patient with a history of acute myeloid leukemia--case report and review of the literature. Haematologica; 2006 Dec;91(12 Suppl):ECR55
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  • [Title] Anaplastic large cell lymphoma with involvement of the pancreas presenting as panniculitis in a patient with a history of acute myeloid leukemia--case report and review of the literature.
  • A CT scan of the abdomen demonstrated an enlargement of the head and uncinate of pancreas and diffuse lymphadenopathy.
  • The patient developed respiratory distress and expired.
  • An autopsy of the pancreas revealed clusters of large, atypical cells, which morphologically and immunophenotypically were consistent with CD30 positive, ALK-negative anaplastic large cell lymphoma (ALCL) of T-cell lineage and multifocal fat necrosis (panniculitis) in the peripancreatic adipose tissue.
  • This is the first case of ALCL of the pancreas and panniculitis in a patient with history of AML.
  • [MeSH-major] Leukemia, Myeloid / drug therapy. Lymphoma, Large-Cell, Anaplastic / diagnosis. Neoplasms, Second Primary / diagnosis. Pancreas / pathology. Panniculitis / etiology


3. Lee MK, Jeon SW, Lee YD, Seo HE, Cho CM, Kim SG, Yoon YK: A case of primary pancreatic non-Hodgkin's lymphoma. Korean J Intern Med; 2006 Jun;21(2):123-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of primary pancreatic non-Hodgkin's lymphoma.
  • Primary pancreatic lymphoma is rare, comprising 0.2-4.9% of all pancreatic malignancies and less than 1% of cases of non-Hodgkin's lymphoma.
  • Many patients are diagnosed with lymphoma after radical resection.
  • We report a rare presentation of diffuse large B cell lymphoma, appearing as a primary tumor of the pancreas.
  • Computed tomography of the abdomen showed a well defined mass located at the head of the pancreas.
  • A frozen section of pancreas, during laparotomy, revealed lymphoma.
  • The patient received 6 cycles of chemotherapy and is currently in complete remission.
  • This case underscores the importance of differentiating primary lymphoma from the more common adenocarcinoma of the pancreas as treatment and prognosis differ significantly.
  • Primary pancreatic lymphoma should be considered in the differential diagnosis of pancreatic tumors and an attempt to obtain a tissue diagnosis is always necessary before proceeding to radical surgery, especially on young patients.
  • [MeSH-major] Lymphoma, B-Cell / therapy. Lymphoma, Large B-Cell, Diffuse / therapy. Pancreatic Neoplasms / therapy

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  • (PMID = 16913443.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3890735
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4. Arcari A, Anselmi E, Bernuzzi P, Bertè R, Lazzaro A, Moroni CF, Trabacchi E, Vallisa D, Vercelli A, Cavanna L: Primary pancreatic lymphoma. Report of five cases. Haematologica; 2005 Feb;90(2):ECR09
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  • [Title] Primary pancreatic lymphoma. Report of five cases.
  • Primary pancreatic lymphoma (PPL) is a very rare disease.
  • None of these patients had evidence of extrapancreatic disease and they were categorized as PPL involving pancreas only (stage IE, 3 patients) or pancreas and peripancreatic lymph nodes (stage IIE, 2 patients).
  • The histological diagnosis (3 diffuse-large cell non-Hodgkin's lymphoma and 2 lymphoplasmacytic lymphoma/immunocytoma) was made by ultrasound-guided fine needle aspiration biopsy and tissue core fine-needle biopsy in three patients and by surgery in the remaining two patients.
  • The three patients diagnosed by percutaneous biopsy were treated with chemotherapy as front-line therapy and two of them received also local radiotherapy; one of these patients is still alive in complete remission at 69 months, one died of an unrelated disease at 67 months and one died of lymphoma relapse at 88 months.
  • Two patients underwent pancreaticoduodenectomy plus adjuvant chemotherapy; one of them died of recurrent cholangitis 8 months after surgery while the other one is still alive in complete remission after 160 months.
  • 2) histological diagnosis can be easily obtained by percutaneous US-guided tissue core biopsy;.
  • 3) surgery can be avoided both for diagnosis and therapy but the treatment of choice of PPL may only be evaluated on a larger series of patients.
  • [MeSH-major] Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Aged. Biopsy. Biopsy, Needle. Female. Humans. Male. Middle Aged. Recurrence. Remission Induction. Retrospective Studies. Treatment Outcome

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  • (PMID = 15713583.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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5. Oshiro A, Nagasaki A, Nakachi A, Uchima N, Hasegawa H, Nakazato T, Nakamoto M, Kinjo N, Kinjo F, Taira N, Masuda M, Takasu N: [A case of primary malignant lymphoma of the duodenum successfully treated with dose escalating chemotherapy]. Gan To Kagaku Ryoho; 2003 Aug;30(8):1169-73
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  • [Title] [A case of primary malignant lymphoma of the duodenum successfully treated with dose escalating chemotherapy].
  • A 65-year-old woman with diabetes mellitus was hospitalized for heart failure and anemia in August 2001, and recovered with conservative treatment.
  • Abdominal CT scan demonstrated tumor involvement in the pancreas head.
  • The diagnosis of a diffuse large B-cell lymphoma, clinical stage IIE, was made by endoscopic biopsy.
  • Although surgical resection of the localized intestinal tumor would have been a common choice for initial treatment, polychemotherapy was selected; the patient had diabetes mellitus and preferred polychemotherapy to surgical operation.
  • Because of bulky intestinal mass, transmural disease and sensitive histological type, standard-dose chemotherapy was considered to include a high risk of intestinal perforation.
  • We performed dose-escalating chemotherapy: A half dose of THP-COP (pirarubicin, cyclophosphamide, vincristine) was given at the start in October 2001, 60% THP-COP as the next cycle, 80% THP-COP as the 3rd cycle and thereafter.
  • Without serious complications of the intestine, she received a total of 6 cycles of chemotherapy and subsequent involved field radiation.
  • There has been no evidence of recurrence of disease 14 months from the start of chemotherapy.
  • When conditions make surgical treatment difficult, dose-escalating chemotherapy in a treatment cycle may be considered as an alternative.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Duodenal Neoplasms / drug therapy. Lymphoma, B-Cell / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy. Prednisolone / therapeutic use. Vincristine / therapeutic use
  • [MeSH-minor] Aged. Female. Humans. Treatment Outcome

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  • (PMID = 12938276.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VEP-THP protocol
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6. Yoon WJ, Yoon YB, Kim YJ, Ryu JK, Kim YT: Primary pancreatic lymphoma in Korea--a single center experience. J Korean Med Sci; 2010 Apr;25(4):536-40
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  • [Title] Primary pancreatic lymphoma in Korea--a single center experience.
  • The aim of this study was to report a single center experience of primary pancreatic lymphoma (PPL) in Korea.
  • The diagnoses were: diffuse large B cell lymphoma (n=2), Ki-1 (+) anaplastic large cell lymphoma (n=1), and Burkitt lymphoma (n=1).
  • Two patients underwent treatment.
  • The stage IEA patient underwent chemotherapy and radiation therapy that resulted in a complete remission.
  • The stage IVEB patient who underwent chemotherapy relapsed.
  • This patient underwent subsequent peripheral blood stem cell transplantation and is alive at 30 months.
  • Two patients (stages IVEB and IIEA) without treatment died at 0.8 and 7.0 months, respectively.
  • For PPL patients, chemotherapy-based treatment, and addition of radiation therapy, if possible, may offer good prognosis.
  • [MeSH-major] Lymphoma / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Korea. Male. Middle Aged. Prognosis. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 20357994.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2844603
  • [Keywords] NOTNLM ; Lymphoma / Pancreas
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7. Bernardeau M, Auroux J, Cavicchi M, Haioun C, Tsakiris L, Delchier JC: Secondary pancreatic involvement by diffuse large B-cell lymphoma presenting as acute pancreatitis: treatment and outcome. Pancreatology; 2002;2(4):427-30
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  • [Title] Secondary pancreatic involvement by diffuse large B-cell lymphoma presenting as acute pancreatitis: treatment and outcome.
  • We report the case of a 33-year-old man who presented with a large B-cell non Hodgkin's lymphoma presenting as acute pancreatitis.
  • Abdominal CT showed diffuse swelling of the pancreas, with two distinct masses in the corpus and the tail.
  • Direct biopsy of this mass revealed a large B-cell lymphoma.
  • Chemotherapy followed by peripheral blood cell autotransplantation led to complete disappearance of the pancreatic and mediastinal masses.
  • Fatty diarrhea occurred after chemotherapy, probably owing to gland destruction by lymphomatous infiltration.
  • [MeSH-major] Lymphoma, B-Cell / complications. Lymphoma, Large B-Cell, Diffuse / complications. Pancreatic Neoplasms / complications. Pancreatitis / etiology
  • [MeSH-minor] Acute Disease. Adult. Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Exocrine Pancreatic Insufficiency / chemically induced. Humans. Male. Remission Induction. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2002 S. Karger AG, Basel and IAP
  • (PMID = 12138234.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Phytogenic; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide
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8. Hashimoto M, Umekita N, Noda K: Non-Hodgkin lymphoma as a cause of obstructive jaundice with simultaneous extrahepatic portal vein obstruction: a case report. World J Gastroenterol; 2008 Jul 7;14(25):4093-5
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  • [Title] Non-Hodgkin lymphoma as a cause of obstructive jaundice with simultaneous extrahepatic portal vein obstruction: a case report.
  • Non-Hodgkin lymphoma is a rare cause of biliary obstruction.
  • To the best of our knowledge, non-Hodgkin lymphoma in the peripancreatic region causing obstructive jaundice with simultaneous portal vein (PV) invasion has not yet been reported.
  • We present a 50-year-old patient with obstructive jaundice whose extrahepatic portal vein was obstructed by the invasion of a peripancreatic non-Hodgkin lymphoma.
  • Computed tomography (CT) revealed a 10 cm mass in the retroperitoneal space behind the head of the pancreas causing obstruction of the distal bile duct and the PV.
  • Histological examination showed the mass consisting of diffuse sheets of large malignant lymphoid cells.
  • The pathologic diagnosis was diffuse large B-cell type non-Hodgkin lymphoma and the patient was transferred to the Department of Hematology and Oncology for chemotherapy.
  • He received four cycles of combined chemotherapy including cyclophosphamide, doxorubicin, vincristine and prednisone plus rituximab, and three cycles of intrathecal chemoprophylaxis including methotorexate, cytosine arbinoside and prednisone.
  • The patient is alive with no evidence of the disease for 7 mo after operation and will receive additional courses of chemotherapy.
  • [MeSH-major] Jaundice, Obstructive / etiology. Lymphoma, Large B-Cell, Diffuse / pathology. Portal Vein / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Bile Ducts / pathology. Chemotherapy, Adjuvant. Humans. Jugular Veins / transplantation. Male. Middle Aged. Neoplasm Invasiveness. Pancreaticoduodenectomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18609698.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2725353
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9. Cibeira MT, Lopez-Guillermo A, Colomer D, Ricart MJ, Alcaraz A, Martinez A, Campo E, Montserrat E: Diffuse large B-cell lymphoma arising from donor lymphoid cells after renal and pancreatic transplantation. Ann Hematol; 2003 Feb;82(2):131-5
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  • [Title] Diffuse large B-cell lymphoma arising from donor lymphoid cells after renal and pancreatic transplantation.
  • A patient with both a renal and pancreatic transplantation developed a diffuse large B-cell lymphoma, Epstein-Barr virus-related, 14 months after the surgical procedure.
  • Tumor was confined to the transplanted organs: head of the pancreas and hilar lymph node of the transplanted kidney.
  • Immunosuppression was discontinued and chemotherapy with cyclophosphamide, hydroxydaunomycin, vincristine, and prednisone (CHOP) was started.
  • [MeSH-major] Kidney Transplantation / adverse effects. Lymphoma, B-Cell / virology. Lymphoma, Large B-Cell, Diffuse / virology. Pancreas Transplantation / adverse effects


10. Manz MG, Berger C, Horny HP, Beck R, Brugger W, Viebahn R, Kanz L, Knecht H: Sustained remission of an extensive monoclonal, Epstein-Barr virus-associated diffuse large B cell lymphoma in a kidney-pancreas transplant recipient. Transplantation; 2002 Mar 27;73(6):995-7
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  • [Title] Sustained remission of an extensive monoclonal, Epstein-Barr virus-associated diffuse large B cell lymphoma in a kidney-pancreas transplant recipient.
  • BACKGROUND: Epstein-Barr virus associated posttransplant high-grade large cell lymphoma (EBV-PTL) is thought to be incurable solely by cessation of immunosuppression.
  • A strong cytotoxic memory T cell (CTL) reaction against two individual recipient EBV strains appears to be involved.
  • RESULTS: Stage IIIB EBV-PTL of recipient type was cured through strong autologous CTL reaction consecutive to alleviation of immunosuppression.
  • Latent membrane protein 1 fingerprinting identified three different EBV strains; namely in lymphoma and peripheral lymphocytes of donor and recipient.
  • [MeSH-major] Diabetes Mellitus, Type 1 / surgery. Herpesvirus 4, Human / isolation & purification. Kidney Transplantation. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Pancreas Transplantation
  • [MeSH-minor] Adult. Drug Therapy, Combination. Humans. Immunosuppressive Agents / therapeutic use. Lymph Nodes / pathology. Male. Postoperative Complications. Reoperation. Spleen / virology. Tissue Donors. Treatment Outcome


11. Fraser CJ, Chan YF, Heath JA: Anaplastic large cell lymphoma of the pancreas: a pediatric case and literature review. J Pediatr Hematol Oncol; 2004 Dec;26(12):840-2
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  • [Title] Anaplastic large cell lymphoma of the pancreas: a pediatric case and literature review.
  • Examination of a biopsy specimen obtained by open laparotomy revealed malignant lymphoma.
  • Histology, immunohistochemistry, and cytogenetics confirmed the diagnosis of ALK1-positive anaplastic large cell lymphoma.
  • He was treated with multiagent chemotherapy and remains in complete remission 12 months off treatment.
  • This is the first case of primary pancreatic ALK1-positive anaplastic large cell lymphoma described in a child and shows that aggressive surgical resection of pancreatic tumors is not always necessary to achieve a cure.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Abdominal Pain / etiology. Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Treatment Outcome

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  • (PMID = 15591909.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Schiefke I, Tröltzsch M, Keim V: [Pitfalls in diagnosis of non-Hodgkin-lymphoma of the pancreas]. Ultraschall Med; 2002 Dec;23(6):407-10
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  • [Title] [Pitfalls in diagnosis of non-Hodgkin-lymphoma of the pancreas].
  • An computed tomography (CT) did not show the lesion in the pancreas.
  • The biopsy specimen revealed a diffuse large cell Non-Hodgkin-Lymphoma.
  • This case report illustrates, how simple ultrasound studies can detect lesions not seen in more expensive, complex, and time consuming imaging techniques like CT.
  • The patient underwent a postoperative chemotherapy and is currently well.
  • [MeSH-major] Lymphoma, Non-Hodgkin / ultrasonography. Pancreatic Neoplasms / ultrasonography
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Female. Humans. Reproducibility of Results. Tomography, X-Ray Computed

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  • (PMID = 12514759.001).
  • [ISSN] 0172-4614
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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13. Ueda K, Nagayama Y, Narita K, Kusano M, Mernyei M, Kamiya M: Pancreatic involvement by non-Hodgkin's lymphoma. J Hepatobiliary Pancreat Surg; 2000;7(6):610-3
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  • [Title] Pancreatic involvement by non-Hodgkin's lymphoma.
  • A case of pancreatic involvement by non-Hodgkin's lymphoma is presented.
  • The patient, a 63-year-old man had a large tumor in the head of the pancreas, without obstructive jaundice.
  • Therefore, pancreatoduodenectomy and right hemicolectomy were performed, although a definitive preoperative diagnosis was not obtained.
  • This tumor was identified, by histopathology and immunohistochemistry, as diffuse mixed type lymphoma with a B-cell phenotype.
  • Postoperatively, the patient had severe congestive heart failure, and he died without receiving chemotherapy.
  • It is important to establish a definitive diagnosis for this disease, to remove the tumor, and to treat the patient with appropriate chemotherapy.
  • [MeSH-major] Lymphoma, Non-Hodgkin / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Fatal Outcome. Heart Neoplasms / radiography. Heart Neoplasms / secondary. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 11180896.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Boni L, Benevento A, Dionigi G, Cabrini L, Dionigi R: Primary pancreatic lymphoma. Surg Endosc; 2002 Jul;16(7):1107-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pancreatic lymphoma.
  • Primary pancreatic lymphoma (PPL) is a rare form of extranodal lymphoma (less than 0.5% of pancreatic tumors) originating from the pancreatic parenchyma.
  • Histopathological examination is usually mandatory to obtain a definitive diagnosis since symptoms and radiological features are quite similar to those of other pancreatic masses.
  • Percutaneous fine-needle aspiration (FNA) of the pancreas requires experienced cytopathologists as well as advanced immunohistochemical assays to obtain a final diagnosis on a small amount of tissue.
  • Abdominal ultrasound revealed the presence of a large hyperechogenic mass, mainly located at the pancreatic head.
  • Abdominal computed tomography scan confirmed a diffuse enlargement of the head and body of the pancreas associated with lymphadenopathy along the lesser gastric curvature.
  • Percutaneous ultrasound-guided FNA of the pancreas as well as gross biopsy of the axillary lymph nodes were unable to identify the nature of the mass.
  • The definitive histopathological examination of the pancreatic specimen revealed a primary low-grade non-Hodgkin B cell pancreatic lymphoma.
  • The postoperative course was unremarkable; the patient underwent systemic chemotherapy regime for low-grade B cell Hodgkin lymphoma and he was symptom free at 9-month follow-up.
  • [MeSH-major] Lymphoma, B-Cell / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Diabetes Mellitus, Type 1 / surgery. Diagnostic Techniques, Surgical. Humans. Laparoscopy / methods. Lymph Node Excision / methods. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 11984658.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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15. Martino A, Festa P, La Rocca F, Romagnuolo G, Bartone G, Di Muria A, Napolitano G, De Sena G, Martino R, Nappi O: [Abdominal lymphoma with abscess and thoracic perforation: en-bloc resection]. Ann Ital Chir; 2002 Jul-Aug;73(4):445-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Abdominal lymphoma with abscess and thoracic perforation: en-bloc resection].
  • The authors compare a rare case of acute onset Gastric Lymphoma with that present in the literature.
  • On CT scan an opacity of the pleura and a subtotal collapse of the left lung associated with a mass infiltrating the diaphragm, the gastric fundus and pancreas were seen.
  • The histology showed an high malignant, diffused, big cell lymphoma.
  • Surgery can be necessary, sometime curative in gastric lymphomas while long term result and quality of life could be improved by chemotherapy.
  • [MeSH-major] Abdominal Abscess / etiology. Lymphoma, Large B-Cell, Diffuse / complications. Stomach Neoplasms / complications

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  • (PMID = 12661236.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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16. NAGAI Y, MORI M, INOUE D, KIMURA T, SHIMOJI S, TOGAMI K, TABATA S, MATSUSHITA A, NAGAI K, Imai Y, Takafuta T, Takahashi T: Successful treatment with autologous peripheral blood stem cell transplantation for acquired immunodeficiency syndrome (AIDS)-related malignant lymphoma. Rinsho Ketsueki; 2009 Nov;50(11):1641-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment with autologous peripheral blood stem cell transplantation for acquired immunodeficiency syndrome (AIDS)-related malignant lymphoma.
  • Histologic diagnosis of a biopsied lymph node was diffuse, large, B cell-type malignant lymphoma.
  • The karyotype of the lymphoma cells was t(8;14)(q24;q32), which was confirmed by G-banding and fluorescent in situ hybridization.
  • Positron emission tomography (PET)-combined CT scanning revealed systemic extranodal tumors involving the gastrointestinal tract, pancreas, and bone marrow.
  • The clinical stage of the lymphoma was IVB and the international prognosis index was categorized as high.
  • Complete remission (CR) of the lymphoma was obtained after 2 courses of CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone) chemotherapy and 4 subsequent courses of rituximab-combined CHOP (R-CHOP).
  • Highly active antiretroviral therapy (HAART) was started at the initiation of CHOP.
  • Because of the poor prognosis of AIDS-related lymphoma, he received autologous peripheral blood stem cell transplantation with the MEAM protocol (ranimustine, etoposide, cytarabine, melphalan) as a conditioning procedure without a severe infectious episode.
  • [MeSH-major] Lymphoma, AIDS-Related / therapy. Lymphoma, Large B-Cell, Diffuse / therapy. Peripheral Blood Stem Cell Transplantation
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Antiretroviral Therapy, Highly Active. Combined Modality Therapy. Cyclophosphamide. Doxorubicin. Humans. Male. Middle Aged. Prednisolone. Remission Induction. Rituximab. Transplantation Conditioning. Transplantation, Autologous. Treatment Outcome. Vincristine

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  • (PMID = 20009441.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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17. Shoji T, Konno H, Tanaka T, Baba M, Kamiya K, Kaneko T, Igarashi A, Nakamura S: Pancreaticoduodenectomy for perforated gastric malignant lymphoma: report of a case. Surg Today; 2002;32(5):468-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreaticoduodenectomy for perforated gastric malignant lymphoma: report of a case.
  • We herein report the case of a 65-year old man with gastroduodenal malignant lymphoma (diffuse large B-cell type) accompanied with a bulbar perforation.
  • The postoperative course was uneventful and CHOP therapy (pirarubicin 30 mg/m2, cyclophosphamide 500 mg/m2, vincristine 1 mg/m2, prednisolone 30 mg/m2) was started 1 month after surgery.
  • Seven cycles of CHOP therapy markedly reduced the residual lesions including lymph nodes, and a computed tomography scan after the final chemotherapy revealed no obvious lesions.
  • [MeSH-major] Lymphoma, B-Cell / surgery. Lymphoma, Large B-Cell, Diffuse / surgery. Pancreaticoduodenectomy. Stomach Neoplasms / surgery
  • [MeSH-minor] Aged. Duodenum / pathology. Humans. Male. Neoplasm Invasiveness. Palliative Care. Pancreas / pathology. Rupture, Spontaneous

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  • (PMID = 12061704.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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18. Kalil AN, Reck dos Santos PA, Azambuja DB, Beck PE: A case of retroperitoneal lymphoma presenting as pancreatic tumor. Hepatogastroenterology; 2004 Jan-Feb;51(55):259-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of retroperitoneal lymphoma presenting as pancreatic tumor.
  • We describe a case of non-Hodgkin's lymphoma arising in the peripancreatic retroperitoneal lymph node and extending into the pancreatic parenchyma.
  • Abdominal ultrasonogram and computed tomography of the abdomen showed an mass in the head of pancreas with absence of extrapancreatic disease and no direct tumor extension to the portal vein or superior mesenteric artery.
  • Laparotomy demonstrated a large pancreatic mass with no obstruction of common bile duct or encasement of portal vein and superior mesenteric artery and a pancreaticoduodenectomy was performed.
  • He received chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone.
  • The patient is alive and in remission with a follow-up time of 24 months.
  • [MeSH-major] Lymphoma, Large B-Cell, Diffuse / diagnosis. Pancreatic Neoplasms / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 15011880.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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19. Dote H, Ohta K, Nishimura R, Teramoto N, Asagi A, Nadano S, Hamada M, Yoshida I, Kobatake T, Nozaki I, Kubo Y, Tanada M, Kurita A, Takashima S: Primary extranodal non-Hodgkin's lymphoma of the common bile duct manifesting as obstructive jaundice: report of a case. Surg Today; 2009;39(5):448-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary extranodal non-Hodgkin's lymphoma of the common bile duct manifesting as obstructive jaundice: report of a case.
  • Primary non-Hodgkin's lymphoma (NHL) of the common bile duct (CBD) manifesting as obstructive jaundice is extremely rare: to our knowledge, only 22 cases of primary NHL arising from the CBD have been reported.
  • Abdominal sonography, positron emission tomography, and computed tomography showed a mass with abnormal 18-fluorodeoxyglucose uptake in pancreatic head.
  • We performed pancreaticoduodenectomy for a presumptive diagnosis of pancreatic head carcinoma or cholangiocarcinoma of the CBD.
  • However, the histological diagnosis was a primary, diffuse, large B-cell lymphoma of the CBD.
  • He received three courses of combination chemotherapy, including rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP).
  • In summary, primary NHL of the CBD, despite its rarity, should be considered in the differential diagnosis of obstructive jaundice.
  • An accurate histopathologic diagnosis and complete surgical resection, followed by combination chemotherapy plus rituximab may be effective.
  • [MeSH-major] Common Bile Duct / pathology. Common Bile Duct Neoplasms / diagnosis. Jaundice, Obstructive / diagnosis. Lymphoma, Non-Hodgkin / diagnosis
  • [MeSH-minor] Humans. Male. Middle Aged. Pancreas / pathology. Pancreas / surgery. Pancreaticoduodenectomy

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  • [Cites] Surg Today. 2007;37(7):608-11 [17593484.001]
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  • (PMID = 19408087.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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20. Blaes AH, Peterson BA, Bartlett N, Dunn DL, Morrison VA: Rituximab therapy is effective for posttransplant lymphoproliferative disorders after solid organ transplantation: results of a phase II trial. Cancer; 2005 Oct 15;104(8):1661-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rituximab therapy is effective for posttransplant lymphoproliferative disorders after solid organ transplantation: results of a phase II trial.
  • BACKGROUND: Posttransplant lymphoproliferative disorders (PTLD) remain an uncommon complication of solid organ transplantation with a high mortality rate reported after conventional therapies.
  • Alternative treatments such as rituximab have been explored.
  • The type of solid organ transplantation that these patients received included lung (five patients), kidney (four patients), heart (one patient), and kidney/pancreas (one patient).
  • The median time from transplantation to a PTLD diagnosis was 9 months (range, 1-122 mos).
  • Diagnostic B-cell histology was diffuse large cell lymphoma or polymorphous process.
  • Immunosuppressive therapy was decreased at the time of diagnosis.
  • The median time to treatment failure was 10 months (range, 5-25+ mos).
  • Four patients were alive at the time of last follow-up.
  • Further evaluation of rituximab in these disorders, potentially in combination with other therapies, is warranted.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Lymphoma, B-Cell / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy. Organ Transplantation / adverse effects. Postoperative Complications / drug therapy
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal, Murine-Derived. Female. Humans. Male. Middle Aged. Prognosis. Rituximab. Survival Rate. Time Factors. Treatment Outcome

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  • [Copyright] Copyright 2005 American Cancer Society
  • (PMID = 16149091.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
  • [Number-of-references] 40
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21. Halkos ME, Miller JI, Mann KP, Miller DL, Gal AA: Thoracic presentations of posttransplant lymphoproliferative disorders. Chest; 2004 Dec;126(6):2013-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Transplanted organs included lungs (three patients), kidneys (three patients), kidney/pancreas (two patients), allogeneic bone marrow (two patients), and heart (one patient).
  • The time to presentation ranged from 1 to 97 months (median time, 8 months).
  • Six patients developed PTLD within 1 year of undergoing transplantation.
  • Diagnosis was achieved by CT-guided transthoracic needle biopsy in eight patients, and by open biopsy in three patients.
  • Pathologic analysis revealed monomorphic PTLD (ie, diffuse large B-cell lymphoma) in seven patients, polymorphic PTLD in two patients, anaplastic large cell lymphoma in one patient, and Hodgkin lymphoma in one patient.
  • All patients were initially treated with a reduction in immunosuppression therapy, and six patients (55%) received adjuvant chemotherapy.
  • The median interval from diagnosis to death was 13 months (range, 1 to 42 months).
  • Heart and lung allograft recipients have the worst prognosis because of the mortality that accompanies rejection with subtherapeutic immunosuppression therapy.
  • Earlier diagnosis and improvements in immunosuppression and chemotherapy may improve survival for these inherently high-risk patients.
  • [MeSH-major] Lymphoproliferative Disorders / diagnosis. Thoracic Diseases / diagnosis. Transplantation / adverse effects
  • [MeSH-minor] Adult. Antibodies, Viral / analysis. Cytomegalovirus / isolation & purification. Female. Herpesvirus 4, Human / isolation & purification. Humans. Lymphoma / diagnosis. Lymphoma / etiology. Lymphoma / therapy. Lymphoma / virology. Male. Middle Aged

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  • (PMID = 15596707.001).
  • [ISSN] 0012-3692
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Viral
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