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1. Zermatten P, Angelillo-Scherrer A, Theumann N, Dutoit M, Chevalley F: Painful periarticular calcifications after muscle injury at the hip in a patient with moderate haemophilia A. Haemophilia; 2008 May;14(3):651-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Coagulants / therapeutic use. Factor VIII / therapeutic use. Hemophilia A / complications. Ossification, Heterotopic / complications. Wounds, Nonpenetrating / complications
  • [MeSH-minor] Adult. Hematoma / etiology. Hip Joint. Humans. Magnetic Resonance Imaging. Male. Muscle, Skeletal / injuries. Pain / drug therapy. Pain / etiology. Pelvis. Tomography, X-Ray Computed

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  • (PMID = 18393982.001).
  • [ISSN] 1365-2516
  • [Journal-full-title] Haemophilia : the official journal of the World Federation of Hemophilia
  • [ISO-abbreviation] Haemophilia
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coagulants; 0 / F8 protein, human; 9001-27-8 / Factor VIII
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2. Chakarian JC, Héron F, Belizna C, Hervé F, Maillochaud JH, Marie I, Lévesque H: [Spontaneous splenic hematoma: trauma injury or drug reaction or both?]. Presse Med; 2005 Dec 17;34(22 Pt 1):1717-8
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  • [Title] [Spontaneous splenic hematoma: trauma injury or drug reaction or both?].
  • [Transliterated title] Hématome spontané de la rate: traumatisme et/ou médicament?
  • CASE: We report the case of a 45-year-old man consulting for abdominal pain that was found to be due to a spontaneous splenic hematoma.
  • This history suggested that the drug might play a role.
  • DISCUSSION: Although the likely cause of this splenic hematoma appears to be a minor injury 9 months before the onset of pain, we cannot rule out the possibility that selective serotonin reuptake inhibitor treatment was a predisposing factor.
  • [MeSH-major] Hematoma / diagnosis. Splenic Diseases / diagnosis
  • [MeSH-minor] Abdominal Pain / etiology. Accidental Falls. Accidents, Occupational. Depression / drug therapy. Humans. Male. Middle Aged. Serotonin Uptake Inhibitors / therapeutic use. Shoulder Joint / injuries

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  • (PMID = 16374394.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Serotonin Uptake Inhibitors
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3. Bindelglass DF, Rosenblum DS: Neuraxial hematoma and paralysis after enoxaparin administration 3 days after attempted spinal anesthesia for total knee arthroplasty. J Arthroplasty; 2010 Oct;25(7):1169.e9-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuraxial hematoma and paralysis after enoxaparin administration 3 days after attempted spinal anesthesia for total knee arthroplasty.
  • He was placed on enoxaparin at a therapeutic dose that begun more than 72 hours after his attempted spinal.
  • He developed a spinal hematoma and was paralyzed.
  • The literature has no recommendations for using enoxaparin at therapeutic doses after regional anesthesia.
  • There is no previous report to suggest that a patient 72 hours after surgery is still at risk from a neuraxial hematoma.
  • [MeSH-major] Anesthesia, Spinal. Anticoagulants / adverse effects. Arthroplasty, Replacement, Knee. Enoxaparin / adverse effects. Hematoma, Epidural, Spinal / chemically induced. Paralysis / chemically induced
  • [MeSH-minor] Aged. Dose-Response Relationship, Drug. Humans. Male. Osteoarthritis, Knee / surgery. Pulmonary Embolism / drug therapy. Risk Factors. Time Factors. Venous Thrombosis / prevention & control

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19837550.001).
  • [ISSN] 1532-8406
  • [Journal-full-title] The Journal of arthroplasty
  • [ISO-abbreviation] J Arthroplasty
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Enoxaparin
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4. Singelyn FJ, Verheyen CC, Piovella F, Van Aken HK, Rosencher N, EXPERT Study Investigators: The safety and efficacy of extended thromboprophylaxis with fondaparinux after major orthopedic surgery of the lower limb with or without a neuraxial or deep peripheral nerve catheter: the EXPERT Study. Anesth Analg; 2007 Dec;105(6):1540-7, table of contents
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  • BACKGROUND: The benefit-risk ratio of extended fondaparinux therapy has not been assessed in patients undergoing major lower limb joint arthroplasty.
  • We performed a prospective intervention study in patients undergoing major orthopedic surgery primarily designed to assess the efficacy of fondaparinux when drug administration was withheld for 48 h to permit removal of a neuraxial or deep peripheral nerve catheter.
  • The safety and efficacy of extended fondaparinux therapy for the prevention of venous thromboembolism were also evaluated.
  • No neuraxial or perineural hematoma was reported.
  • [MeSH-major] Catheterization / methods. Lower Extremity / surgery. Orthopedic Procedures / methods. Peripheral Nerves. Polysaccharides / administration & dosage. Thrombolytic Therapy / methods
  • [MeSH-minor] Aged. Female. Humans. Internationality. Male. Middle Aged. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Prospective Studies. Time Factors. Venous Thrombosis / etiology. Venous Thrombosis / prevention & control

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  • [CommentIn] Anesth Analg. 2009 Feb;108(2):670-1; author reply 671-2 [19151310.001]
  • (PMID = 18042845.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polysaccharides; J177FOW5JL / fondaparinux
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5. Kaneda T, Urimoto G, Suzuki T: Spinal epidural hematoma following epidural catheter removal during antiplatelet therapy with cilostazol. J Anesth; 2008;22(3):290-3
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  • [Title] Spinal epidural hematoma following epidural catheter removal during antiplatelet therapy with cilostazol.
  • After an epidural catheter (used for intraoperative/postoperative management) was removed, a spinal epidural hematoma involving the Th12 to L3 areas developed.
  • Emergency removal of the hematoma and decompression of the spinal cord were performed.
  • Possibly, the hematoma had developed due to therapy with an antiplatelet agent, cilostazol, which had been started on the first postoperative day, and due to the removal of the catheter, on the third postoperative day, in addition to the patient's advanced age.
  • This case may be the first report of spinal epidural hematoma associated with both cilostazol and epidural anesthesia.
  • From the time course in this patient, important knowledge of drug actions and follow-up may be gained for determining the timing of catheter removal in a patient receiving antiplatelet therapy with cilostazol.
  • [MeSH-major] Anesthesia, Epidural / adverse effects. Device Removal / adverse effects. Hematoma, Epidural, Spinal / etiology. Platelet Aggregation Inhibitors / adverse effects. Tetrazoles / adverse effects
  • [MeSH-minor] Aged, 80 and over. Humans. Male. Treatment Outcome

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  • (PMID = 18685937.001).
  • [ISSN] 0913-8668
  • [Journal-full-title] Journal of anesthesia
  • [ISO-abbreviation] J Anesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Platelet Aggregation Inhibitors; 0 / Tetrazoles; N7Z035406B / cilostazol
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6. Hadjipavlou AG, Katonis PG, Tzermiadianos MN, Tsoukas GM, Sapkas G: Principles of management of osteometabolic disorders affecting the aging spine. Eur Spine J; 2003 Oct;12 Suppl 2:S113-31
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  • In this context, one must be certain before attributing low back pain to PD exclusively, and antipagetic medical treatment alone may be ineffective.
  • Neural element dysfunction may be attributed to compressive myelopathy by pagetic bone overgrowth, pagetic intraspinal soft tissue overgrowth, ossification of epidural fat, platybasia, spontaneous bleeding, sarcomatous degeneration and vertebral fracture or subluxation.
  • Because the effectiveness of pharmacologic treatment for pagetic spinal stenosis has been clearly demonstrated, surgical decompression should only be instituted after failure of antipagetic medical treatment.
  • Surgery is indicated as a primary treatment when neural compression is secondary to pathologic fractures, dislocations, spontaneous epidural hematoma, syringomyelia, platybasia, or sarcomatous transformation.
  • Five classes of drugs are available for the treatment of PD.
  • Bisphosphonates are the most popular antipagetic drug and several forms have been investigated.
  • [MeSH-minor] Aged. Humans. Orthopedic Procedures / methods. Spinal Stenosis / etiology. Spinal Stenosis / pathology. Spinal Stenosis / therapy

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  • (PMID = 14505119.001).
  • [ISSN] 0940-6719
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 137
  • [Other-IDs] NLM/ PMC3591829
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7. Morse K, Weight M, Molinari R: Extensive postoperative epidural hematoma after full anticoagulation: case report and review of the literature. J Spinal Cord Med; 2007;30(3):282-7
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  • [Title] Extensive postoperative epidural hematoma after full anticoagulation: case report and review of the literature.
  • The objective of this study was to report a case of postoperative epidural hematoma associated with the use of emergent anticoagulation, including the dangers associated with spinal decompression and early postoperative anticoagulation.
  • FINDINGS: After anticoagulation therapy for postoperative myocardial ischemia, the patient developed paresis with ascending abdominal paraesthesias.
  • Magnetic resonance imaging revealed a massive spinal epidural hematoma extending from the middle of the cervical spine to the sacrum.
  • Emergent cervical, thoracic, and revision lumbar laminectomy without fusion was performed to decompress the spinal canal and evacuate the hematoma.
  • Combined cervical, thoracic, and lumbar laminectomy, without instrumentation or fusion, is an acceptable treatment option.
  • [MeSH-major] Anticoagulants / adverse effects. Decompression, Surgical / adverse effects. Hematoma, Epidural, Spinal / etiology. Heparin / adverse effects. Spinal Stenosis / surgery
  • [MeSH-minor] Aged. Humans. Lumbar Vertebrae. Male. Myocardial Ischemia / drug therapy. Myocardial Ischemia / etiology

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  • (PMID = 17684896.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 9005-49-6 / Heparin
  • [Number-of-references] 15
  • [Other-IDs] NLM/ PMC2031966
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8. Guo W, Yang RL, Tang XD, Tang S, Li DS, Yang Y: [Resection and reconstruction for primary pelvic tumors around acetabular]. Zhonghua Wai Ke Za Zhi; 2004 Dec 7;42(23):1419-22
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  • We must pay more attention on the following points in the surgical treatment of periacetabular tumors:.
  • (3) The reconstructed acetabulum is unstable, so the patients must stand with a cane to protect the reconstructed hip joint;.
  • (5) Surgical treatment of pelvic tumors would easily result in poor wound healing especially in the patients receiving chemotherapy or radiotherapy because of extensive soft tissue stripping.
  • The destroyed soft tissue caused by chemotherapy or radiotherapy may increase the great tissue tension after implantation of allograft.
  • And the factors of poor blood supply and hematoma in the wound theoretically increase the chance of infection.

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  • (PMID = 15733453.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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9. Wissel J, Müller J, Dressnandt J, Heinen F, Naumann M, Topka H, Poewe W: Management of spasticity associated pain with botulinum toxin A. J Pain Symptom Manage; 2000 Jul;20(1):44-9
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  • Pharmacological treatment with oral antispasticity drugs is frequently associated with systemic side effects which limit their clinical use.
  • Intramuscular BtxA injections were placed in muscles exhibiting increased muscle tone in combination with pain during passive joint movement.
  • Patients received a mean total dose of 165.7 +/- 108.2 [30-400] units BOTOX((R)) per treatment session in a mean 3.4 +/- 1.5 muscles.
  • Mild reversible side effects (local pain, hematoma, edema, mild weakness) were observed in four patients.
  • In conclusion, we found that intramuscular BtxA injections are a potent, well-tolerated treatment modality to significantly reduce spasticity-related local pain.
  • This problem may be a main indication, especially in patients with poor response or intolerable side effects to oral medication.
  • [MeSH-major] Botulinum Toxins, Type A / therapeutic use. Muscle Spasticity / complications. Neuromuscular Agents / therapeutic use. Pain / drug therapy

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  • (PMID = 10946168.001).
  • [ISSN] 0885-3924
  • [Journal-full-title] Journal of pain and symptom management
  • [ISO-abbreviation] J Pain Symptom Manage
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Neuromuscular Agents; EC 3.4.24.69 / Botulinum Toxins, Type A
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10. Jiménez-Yuste V, Rodriguez-Merchan EC, Alvarez MT, Quintana M, Fernandez I, Hernandez-Navarro F: Controversies and challenges in elective orthopedic surgery in patients with hemophilia and inhibitors. Semin Hematol; 2008 Apr;45(2 Suppl 1):S64-7
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  • Adequate hemostasis during surgery and postoperative rehabilitation is crucial, as development of a wound hematoma may jeopardize long-term outcomes.
  • It also should be noted that success depends not only on appropriate drug therapy but also on preoperative preparations and adequate perioperative surveillance.
  • [MeSH-major] Blood Coagulation Factor Inhibitors / blood. Hemophilia A / blood. Joint Deformities, Acquired / surgery. Orthopedic Procedures
  • [MeSH-minor] Blood Coagulation Factors / therapeutic use. Elective Surgical Procedures. Factor VIIa / therapeutic use. Humans. Recombinant Proteins / therapeutic use

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  • (PMID = 18544428.001).
  • [ISSN] 0037-1963
  • [Journal-full-title] Seminars in hematology
  • [ISO-abbreviation] Semin. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Coagulation Factor Inhibitors; 0 / Blood Coagulation Factors; 0 / Recombinant Proteins; 0 / recombinant FVIIa; EC 3.4.21.21 / Factor VIIa
  • [Number-of-references] 26
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11. Lee JY, Nassr A, Ponnappan RK: Epidural hematoma causing paraplegia after a fluoroscopically guided cervical nerve-root injection. A case report. J Bone Joint Surg Am; 2007 Sep;89(9):2037-9
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  • [Title] Epidural hematoma causing paraplegia after a fluoroscopically guided cervical nerve-root injection. A case report.
  • [MeSH-major] Analgesia, Epidural / adverse effects. Fluoroscopy. Hematoma, Epidural, Spinal / etiology. Paraplegia / etiology. Radiography, Interventional
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Injections, Epidural / adverse effects. Magnetic Resonance Imaging. Radiculopathy / drug therapy. Spinal Nerve Roots / drug effects

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  • (PMID = 17768203.001).
  • [ISSN] 0021-9355
  • [Journal-full-title] The Journal of bone and joint surgery. American volume
  • [ISO-abbreviation] J Bone Joint Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Alford JW, Palumbo MA, Barnum MJ: Compartment syndrome of the arm: a complication of noninvasive blood pressure monitoring during thrombolytic therapy for myocardial infarction. J Clin Monit Comput; 2002 Apr-May;17(3-4):163-6
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  • [Title] Compartment syndrome of the arm: a complication of noninvasive blood pressure monitoring during thrombolytic therapy for myocardial infarction.
  • We report a rare case of tricep compartment syndrome caused by a hematoma which resulted from noninvasive blood pressure monitoring (NIBPM) during thrombolytic therapy.
  • An understanding of the pathophysiology and clinical presentation of an arm compartment syndrome will allow for prompt diagnosis and surgical treatment.
  • [MeSH-major] Arm / blood supply. Blood Pressure Monitors / adverse effects. Compartment Syndromes / etiology. Hematoma / etiology
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Myocardial Infarction / drug therapy. Thrombolytic Therapy. Tissue Plasminogen Activator / therapeutic use

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13. Azura M, Vanel D, Alberghini M, Picci P, Staals E, Mercuri M: Parosteal osteosarcoma dedifferentiating into telangiectatic osteosarcoma: importance of lytic changes and fluid cavities at imaging. Skeletal Radiol; 2009 Jul;38(7):685-90
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  • As it has practical consequences, with a need for aggressive chemotherapy, we looked for this rather typical imaging pattern.
  • Histology confirmed three cases (the two other only had hematoma inside a dedifferentiated tumor).
  • RESULTS: Lesions involved the distal femur, proximal tibia, and proximal humerus.
  • CONCLUSION: Knowledge of this highly suggestive pattern should help guide the initial biopsy to diagnose the two components of the tumor, and guide aggressive treatment.
  • [MeSH-minor] Adult. Cell Differentiation. Humans. Male. Tomography, X-Ray Computed. Young Adult

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  • [CommentIn] Skeletal Radiol. 2010 Jan;39(1):69; author reply 71 [19826810.001]
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  • [Language] eng
  • [Publication-type] Journal Article
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14. Thakkar SC, Streiff MB, Bruley DF, Mears SC: Case report: perioperative use of protein c concentrate for protein C deficiency in THA. Clin Orthop Relat Res; 2010 Jul;468(7):1986-90
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  • We reviewed studies and case reports pertinent to the treatment of patients with protein C deficiency, especially in the perioperative setting.
  • PURPOSES AND CLINICAL RELEVANCE: THA, a particularly high-risk procedure, is associated with a 40% to 70% incidence of venographic deep venous thrombosis and a 2% to 3% incidence of symptomatic deep venous thrombosis.
  • The use of human zymogen protein C in our patient with heterozygous protein C deficiency during the perioperative period of a THA was associated with no evidence of excessive bleeding, hematoma, deep venous thrombosis, or pulmonary embolism.
  • [MeSH-major] Anticoagulants / therapeutic use. Arthroplasty, Replacement, Hip. Intraoperative Complications / prevention & control. Osteoarthritis, Hip / surgery. Protein C / therapeutic use. Protein C Deficiency / drug therapy
  • [MeSH-minor] Aged. Drug Therapy, Combination. Genotype. Heterozygote. Humans. Intraoperative Care. Male. Mutation. Prothrombin / genetics. Pulmonary Embolism / etiology. Pulmonary Embolism / prevention & control. Treatment Outcome. Venous Thrombosis / etiology. Venous Thrombosis / prevention & control

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  • (PMID = 20012238.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Protein C; 9001-26-7 / Prothrombin
  • [Other-IDs] NLM/ PMC2882006
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15. Riepe G, Schneider M: [V.A.C. instill -- first experiences on an inflammatory process of the proximal femur 3 years after hip-joint operation]. Zentralbl Chir; 2006 Apr;131 Suppl 1:S157-9
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  • [Title] [V.A.C. instill -- first experiences on an inflammatory process of the proximal femur 3 years after hip-joint operation].
  • [MeSH-major] Abscess / surgery. Drug Therapy, Computer-Assisted / instrumentation. Hip Prosthesis. Instillation, Drug. Occlusive Dressings. Prosthesis Failure. Prosthesis-Related Infections / surgery. Surgical Wound Infection / surgery. Thigh / surgery
  • [MeSH-minor] Combined Modality Therapy. Debridement. Hematoma / complications. Humans. Male. Middle Aged. Postoperative Care. Reoperation. Seroma / complications. Vacuum

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  • (PMID = 16575670.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Shem K: Phlegmasia cerulea dolens: rare complication of vena cava filter placement in man with paraplegia. J Spinal Cord Med; 2008;31(4):398-402
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  • Computed tomographic scan suggested a hematoma in the paraspinal and latissimus dorsi muscles.
  • He subsequently developed severe leg pain, followed by hypotension, acute renal failure, and compartment syndrome in bilateral lower extremities requiring fasciotomies.
  • Mechanical and pharmacological thrombectomy was aborted secondary to bleeding complications and hypotension.
  • [MeSH-major] Paraplegia / complications. Spinal Cord Injuries / complications. Thrombophlebitis / etiology. Vena Cava Filters / adverse effects. Venous Thrombosis / therapy
  • [MeSH-minor] Anticoagulants / therapeutic use. Fatal Outcome. Humans. Male. Middle Aged. Pulmonary Embolism / drug therapy. Pulmonary Embolism / etiology. Pulmonary Embolism / radiography. Spinal Fractures / complications. Tomography, X-Ray Computed. Warfarin / therapeutic use

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  • (PMID = 18959358.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Cordero-Ampuero J, de Dios M: What are the risk factors for infection in hemiarthroplasties and total hip arthroplasties? Clin Orthop Relat Res; 2010 Dec;468(12):3268-77
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  • Known risk factors for infection after THA include posttraumatic osteoarthritis, previous surgery, chronic liver disease, corticoid therapy, and excessive surgical time.
  • METHODS: We retrospectively compared 47 patients with a hip arthroplasty (23 hemiarthroplasties, 24 total hip arthroplasties) and late infection with 200 randomly-selected patients with primary arthroplasty (100 hemiarthroplasties, 100 total hip arthroplasties) during the same time period of time without any infection during followup.
  • RESULTS: The following factors were more frequent in late infected hemiarthroplasties: female gender; previous surgery; obesity (body mass index greater than 30 kg/m(2)); glucocorticoid and immunosuppressant treatments; prolonged surgical time; inadequate antibiotic prophylaxis; prolonged wound drainage; hematoma; dislocation; and cutaneous, urinary, and/or abdominal infections.
  • The following were more frequent in infected total hip arthroplasties: posttraumatic osteoarthritis; previous surgery; glucocorticoids; chronic liver disease; alcohol and intravenous drug abuse; prolonged surgical time; prolonged wound drainage; dislocation; subsequent surgery; and cutaneous, urinary, respiratory and abdominal infections.
  • [MeSH-minor] Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Incidence. Male. Prevalence. Retrospective Studies. Risk Assessment. Risk Factors. Spain / epidemiology. Time Factors. Treatment Outcome

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  • (PMID = 20544319.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2974854
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18. Gomoll AH, Kang RW, Williams JM, Bach BR, Cole BJ: Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder. Arthroscopy; 2006 Aug;22(8):813-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder.
  • PURPOSE: Postoperative pain pumps are increasingly used to deliver a continuous infusion of local anesthetic into the surgical wound or the joint.
  • An experimental model is presented that investigates potential chondrotoxic effects of a continuous intra-articular infusion of bupivacaine in the rabbit shoulder.
  • METHODS: We divided 30 rabbits into 3 groups that received continuous infusions of either saline solution, bupivacaine, or bupivacaine with epinephrine into the glenohumeral joint over a period of 48 hours.
  • Animals were killed after 1 week, and osteochondral and synovial samples from the glenohumeral joint underwent analyses with confocal microscopy for live/dead cell assay, metabolic sulfate uptake assessment, and conventional histologic analysis.
  • CONCLUSIONS: Continuous intra-articular infusion of bupivacaine with and without epinephrine led to significant histopathologic and metabolic changes in articular cartilage.
  • The results caution against the use of such devices in applications for smaller joints with minimal clearance or dilution as a result of hematoma, where continuous exposure of cartilage to bupivacaine is expected.
  • [MeSH-major] Analgesia, Patient-Controlled / adverse effects. Anesthetics, Local / adverse effects. Bupivacaine / adverse effects. Cartilage Diseases / chemically induced. Shoulder Joint / drug effects
  • [MeSH-minor] Animals. Cartilage, Articular / drug effects. Disease Models, Animal. Drug Combinations. Epinephrine / administration & dosage. Injections, Intra-Articular. Pain, Postoperative / drug therapy. Rabbits. Synovial Membrane / drug effects

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  • (PMID = 16904576.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Local; 0 / Drug Combinations; Y8335394RO / Bupivacaine; YKH834O4BH / Epinephrine
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19. Lovering AM, Zhang J, Bannister GC, Lankester BJ, Brown JH, Narendra G, MacGowan AP: Penetration of linezolid into bone, fat, muscle and haematoma of patients undergoing routine hip replacement. J Antimicrob Chemother; 2002 Jul;50(1):73-7
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  • [Title] Penetration of linezolid into bone, fat, muscle and haematoma of patients undergoing routine hip replacement.
  • Samples of the haematoma fluid that formed around the operation site and further blood samples for assay were also collected at timed intervals following the operation.
  • Mean concentrations of linezolid in the haematoma fluid drained from around the operation site were 8.2 mg/L at 6-8 h and 5.6 mg/L at 10-12 h after the infusion, and 7.0 mg/L at 2-4 h following a second 600 mg infusion given 12 h post-operatively.
  • We conclude that linezolid exhibits rapid penetration into bone, fat and muscle of patients undergoing hip arthroplasty, to achieve levels in excess of its MIC for susceptible organisms (< or=4 mg/L); therapeutic concentrations were maintained in the haematoma fluid that surrounds the operation site for >16 h.
  • [MeSH-minor] Adipose Tissue / metabolism. Bone and Bones / metabolism. Drug Therapy, Combination. Hematoma / metabolism. Hip Joint / surgery. Humans. Linezolid. Muscles / metabolism. Tissue Distribution

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  • (PMID = 12096009.001).
  • [ISSN] 0305-7453
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Acetamides; 0 / Anti-Infective Agents; 0 / Oxazolidinones; 5CKP8C2LLI / Cefamandole; ISQ9I6J12J / Linezolid
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20. Hough RE, Hampton KK, Preston FE, Channer KS, West J, Makris M: Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors. Br J Haematol; 2000 Dec;111(3):974-9
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  • Prothrombin complex concentrates (PCCs) and, more recently, activated prothrombin complex concentrates (APCCs), are widely used for the treatment of active bleeding in haemophiliacs with inhibitors.
  • [MeSH-major] Blood Coagulation Factors / adverse effects. Factor VIIa / therapeutic use. Hemarthrosis / drug therapy. Hemophilia A / complications. Hemophilia A / drug therapy. Myocardial Infarction / etiology
  • [MeSH-minor] Abdomen. Adult. Aged. Blood Coagulation Factor Inhibitors / blood. Factor VIII. Hematoma / drug therapy. Humans. Knee Joint. Male. Recombinant Proteins / adverse effects. Recombinant Proteins / therapeutic use

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  • (PMID = 11122162.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Blood Coagulation Factor Inhibitors; 0 / Blood Coagulation Factors; 0 / Recombinant Proteins; 37224-63-8 / prothrombin complex concentrates; 9001-27-8 / Factor VIII; EC 3.4.21.21 / Factor VIIa
  • [Number-of-references] 22
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