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1. Hölscher AH, Schröder W, Bollschweiler E, Beckurts KT, Schneider PM: [How safe is high intrathoracic esophagogastrostomy?]. Chirurg; 2003 Aug;74(8):726-33
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  • [Title] [How safe is high intrathoracic esophagogastrostomy?].
  • [Transliterated title] Wie sicher ist die hoch intrathorakale Osophagogastrostomie?
  • The surgical results of transthoracic en bloc esophagectomy and high intrathoracic esophagogastrostomy performed on 109 consecutive patients are presented.
  • Adenocarcinoma was present in 59 patients, squamous cell carcinoma in 45 patients, and other neoplastic lesions of the esophagus in 5 patients: 29.5% of the patients received neoadjuvant radiochemotherapy or chemotherapy alone.
  • On average 33 lymph nodes were dissected from each specimen.
  • Nine patients (8.2%) developed anastomotic leakage.
  • Six of these nine patients were discharged after rethoracotomy and reanastomosis ( n=3) or endoscopic treatment with fibrin glue ( n=3).
  • Only 2 of 103 discharged patients (1.9%) underwent postoperative endoscopic bougienage two or three times because of an anastomotic stenosis.
  • High intrathoracic esophagogastrostomy is a safe anastomosis, which nevertheless requires diligent postoperative management.
  • [MeSH-minor] Adult. Aged. Anastomosis, Surgical. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Endoscopy. Female. Hospital Mortality. Humans. Lymph Node Excision. Male. Middle Aged. Neoadjuvant Therapy. Postoperative Care. Postoperative Complications. Radiotherapy Dosage. Radiotherapy, Adjuvant. Reoperation. Risk Factors. Time Factors

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  • (PMID = 12928793.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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2. Kessel' MM, Agkatsev TV, Lazareva IaV, Perel'man MI: [Surgical treatment for tuberculosis of intrathoracic lymph nodes in children and adolescents]. Probl Tuberk Bolezn Legk; 2006;(5):33-5
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  • [Title] [Surgical treatment for tuberculosis of intrathoracic lymph nodes in children and adolescents].
  • Ninety-four children and adolescents with tuberculosis of intrathoracic lymph nodes (TITLN) were operated on.
  • Late diagnosis and long-term ineffective antituberculous therapy (chemotherapy lasted 2-3 years in 29.8% and 4-5 years in 19.1%) lead to the occurrence of complicated forms of TITLN in 34% of children.
  • Computed tomography (CT) reliably determines the extent, site, and phase of a tuberculous process, assesses the time course of changes in the efficiency of antituberculous therapy.
  • CT aids in defining the optimal time of surgical interventions.
  • Bilateral consecutive one-stage removal of affected lymph nodes is possible in children with bilateral TITLN.
  • [MeSH-major] Tuberculosis, Lymph Node / epidemiology. Tuberculosis, Lymph Node / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Humans. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16850920.001).
  • [ISSN] 1728-2993
  • [Journal-full-title] Problemy tuberkuleza i bolezneĭ legkikh
  • [ISO-abbreviation] Probl Tuberk Bolezn Legk
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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3. Ovsiankina ES, Gubkina MF, Kobulashvili MG, Panova LV: [Chemotherapy for tuberculosis in children and adolescents: problems and ways of their solution]. Probl Tuberk Bolezn Legk; 2006;(8):26-9
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  • [Title] [Chemotherapy for tuberculosis in children and adolescents: problems and ways of their solution].
  • Treatment of 329 patients aged 4-17 years who had first detected tuberculosis was analyzed.
  • The clinical pattern is mainly represented by infiltrative, focal tuberculosis and tuberculosis of intrathoracic lymph nodes (94.5%) and, in single cases, by other forms of tuberculosis.
  • Treatment was performed according to regimens I and III.
  • The time of abacillation is 1-2 months shorter than positive X-ray changes.
  • Microbiological monitoring methods should be primarily used to evaluate the initial combination of chemotherapy.
  • The active application of pathogenetic treatment modalities that promote the acceleration of reparative processes (physiotherapy in particular) generated the necessity of using 3 antituberculous agents in the phase of treatment continuation.
  • [MeSH-major] Antitubercular Agents / therapeutic use. Guidelines as Topic. Tuberculosis, Pulmonary / drug therapy
  • [MeSH-minor] Adolescent. Algorithms. Child. Child, Preschool. Drug Hypersensitivity / epidemiology. Drug Hypersensitivity / etiology. Female. Humans. Male. Severity of Illness Index

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  • (PMID = 17002054.001).
  • [ISSN] 1728-2993
  • [Journal-full-title] Problemy tuberkuleza i bolezneĭ legkikh
  • [ISO-abbreviation] Probl Tuberk Bolezn Legk
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antitubercular Agents
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4. Baltayiannis N, Anagnostopoulos D, Bolanos N, Tsourelis L: Thoracoscopy, bronchoscopy and mediastinoscopy in the staging of lung cancer. J BUON; 2002 Apr-Jun;7(2):141-4
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  • [Title] Thoracoscopy, bronchoscopy and mediastinoscopy in the staging of lung cancer.
  • PURPOSE: To estimate the benefit of Video-Assisted Thoracoscopy (VAT) in the staging of patients with lung cancer.
  • PATIENTS AND METHODS: Between October 1998 and January 2001 VAT was used in 250 patients with histologically proven lung cancer.
  • RESULTS: As a result of VAT 30 patients were upstaged and spared a thoracotomy receiving neo-adjuvant chemotherapy at that point.
  • In 40 patients the procedure was converted into an open thoracotomy and a curative resection was performed during the same session.
  • The remaining 180 patients were deemed inoperable and they received chemotherapy and radiation treatment.
  • It was especially useful in assessing the extent of invasion of various thoracic structures amenable to surgical removal "en block" with the tumor, and in differentiating simple contact of the tumor with an intrathoracic structure from tumor invasion.
  • In addition, it allowed access and sampling of lymph nodes in spaces not easily accessible by mediastinoscopy.

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  • (PMID = 17577278.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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5. Dapri G, Himpens J, Cadière GB: Minimally invasive esophagectomy for cancer: laparoscopic transhiatal procedure or thoracoscopy in prone position followed by laparoscopy? Surg Endosc; 2008 Apr;22(4):1060-9
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  • [Title] Minimally invasive esophagectomy for cancer: laparoscopic transhiatal procedure or thoracoscopy in prone position followed by laparoscopy?
  • This retrospective comparative study aimed to compare two minimally invasive techniques for esophagectomy: transhiatal laparoscopy with intrathoracic or cervical anastomosis (group A) and right thoracoscopy in prone position followed by laparoscopy and left cervicotomy (group B) performed by the same surgeon (G.B.C.).
  • The operative time, perioperative blood loss, intensive care and total hospital stays, peri- and postoperative morbidity, in-hospital mortality, number of lymph nodes dissected, and survival were the outcome measures.
  • METHODS: Between April 1999 and August 2005, 24 patients (group A) and 15 patients (group B) underwent minimally invasive esophagectomy for cancer in the authors' department.
  • Their median age was 61 years in group A and 61 years in group B.
  • One patient (group A) and two patients (group B) received only neoadjuvant chemotherapy, and three patients (group A) received only neoadjuvant radiotherapy.
  • RESULTS: The median operative time was 300 min (range, 240-420 min) in group A and 377 min (range, 240-540 min) in group B (nonsignificant difference [NS]).
  • The median perioperative bleeding was 325 ml (range, 100-800 ml) in group A and 700 ml (range, 100-2,400 ml) in group B (NS).
  • The postoperative medical complications totaled three in group A and six in group B.
  • The postoperative surgical complications included one hemoperitoneum, one pneumothorax, five anastomotic leaks, and two recurrent laryngeal nerve paralyses in group A and two tracheal necroses, four anastomotic leaks, one colic fistula, and three recurrent laryngeal nerve paralyses in group B.
  • The median intensive care unit (ICU) stay was 5 days (range, 2-70 days) for group A and 5 days (range, 1-180 days) for group B (NS).
  • The median hospital stay was 12 days (range, 7-98 days) for group A and 14 days (range, 7-480 days) for group B (p = 0.05).
  • The median number of mediastinal/periesophageal lymph nodes was 3 (range, 1-10) for group A and 4 (range, 2-13) for group B (NS), and the median number of celiac/perigastric lymph nodes was 11 (range, 2-31) for group A and 10 (range, 3-22) for group B (NS).
  • After a median follow-up period of 42.4 months (range, 2-84 months) for group A and 19.1 months (range, 1.5-34 months) for group B, 12 patients in group A died after a median period of 22 months (range, 2-55 months), and 7 patients in group B died after a median time of 15 months (range, 1.5-23 months).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Length of Stay / statistics & numerical data. Lymph Node Excision. Male. Middle Aged. Minimally Invasive Surgical Procedures. Postoperative Complications. Prone Position. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 18071806.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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6. Algar Algar FJ, Alvarez Kindelán A, Fuentes Vaamonde E, Salvatierra Velázquez A, Baamonde Laborda C, López Pujol FJ: [Simultaneaous bilateral pulmonary metastasectomy of carcinoma of the sweat glands]. Arch Bronconeumol; 2002 Aug;38(8):396-8
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  • [Transliterated title] Metastasectomía pulmonar bilateral simultánea de un carcinoma de glándulas sudoríparas.
  • Six years later she developed multiple bilateral lung metastases.
  • Nine nodes were resected from both lungs using a clamshell approach (bilateral transsternal, anterolateral thoracotomy).
  • After surgery, the patient received 6 cycles of adjuvant chemotherapy with cisplatin and 5-fluoruracil.
  • Three years after treatment, no intrathoracic recurrences had occurred and the patient was asymptomatic, with good quality of life.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Sweat Gland Neoplasms
  • [MeSH-minor] Antimetabolites, Antineoplastic / therapeutic use. Antineoplastic Agents / therapeutic use. Axilla. Chemotherapy, Adjuvant. Cisplatin / therapeutic use. Combined Modality Therapy. Female. Fluorouracil / therapeutic use. Follow-Up Studies. Humans. Lymph Node Excision. Middle Aged. Radiography, Thoracic. Thoracotomy. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 12199923.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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7. Antoine M: [Contribution of immunohistochemistry to the management of lung cancer: from morphology to diagnosis and treatment]. Rev Pneumol Clin; 2007 Jun;63(3):183-92
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  • [Title] [Contribution of immunohistochemistry to the management of lung cancer: from morphology to diagnosis and treatment].
  • [Transliterated title] Qu'apporte l'immunohistochimie à la prise en charge du cancer bronchique? De la morphologie au diagnostic et au traitement.
  • We detail here the contribution of IHC to the classification of lung cancer: small-cell lung cancer and other neuroendocrine tumors, basaloid carcinoma, large-cell carcinoma.
  • Using IHC techniques, pathologists can now determine with certainty that an intrathoracic adenocarcinoma is primary or secondary.
  • The distinction is less clear for large-cell carcinoma or squamous-cell carcinoma, or for tumors with a pleural or mediastinal presentation.
  • By demonstrating the presence of carcinomatous cells within the neighboring structures (pleura) or lymph nodes, IHC contributes to lung cancer staging, particularly when there are few of these elements morphologically difficult to distinguish.
  • Finally, IHC contributes to prognosis (proliferation markers, differentiation markers) or prediction of therapeutic response (chemotherapy or targeted therapies).
  • IHC studies may also be requested in a forensic setting, for example to demonstrate that the lung cancer observed in a patient exposed to asbestosis is primary.
  • Other morphological techniques such as hybridization in situ or molecular biology techniques will further complete the histological diagnosis in the future.
  • [MeSH-minor] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Carcinoma, Large Cell / pathology. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / pathology. Chorionic Gonadotropin, beta Subunit, Human / analysis. Forecasting. Humans. Lymph Nodes / pathology. Lymphoma / pathology. Mediastinal Neoplasms / pathology. Melanoma / pathology. Neoplasm Staging. Neuroendocrine Tumors / pathology. Pleural Neoplasms / pathology. Prognosis. Sarcoma / pathology. alpha-Fetoproteins / analysis

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  • (PMID = 17675942.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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8. Erokhin VV, Kornilova ZKh, Alekseeva LP: [The specific features of the detection, clinical manifestations, and treatment of tuberculosis in the HIV-infected]. Probl Tuberk Bolezn Legk; 2005;(10):20-8
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  • [Title] [The specific features of the detection, clinical manifestations, and treatment of tuberculosis in the HIV-infected].
  • The present study has explored the specific features of the detection, clinical manifestations, and treatment of tuberculosis (TB) in 425 patients with TB and HIV infection.
  • According to the time of joining the infections, the patients with TB and HIV infection are divided into 2 basic groups:.
  • 1) HIV infection is primary, TB develops at any stage of HIV infection and 2) TB is primary, HIV injections joins different forms of TB at its any stage.
  • In the pattern of clinical forms of tuberculosis in Group 1, there are prevalent forms of primary tuberculosis with lesion of intrathoracic and peripheral lymph nodes (12.8%), acutely progressive disseminated and miliary tuberculosis of the lung and extrapulmonary systems and organs (49%), among them, meningitis accounts for 4%, lesions of the liver, spleen, kidney, and other organs form 17%.
  • The proportion of TB/HIV patients with drug abuse (65%), hepatitis B and C (47%), and nervous and mental diseases is extremely high, which makes these patients more hazardous to the healthy population.
  • The efficiency of treatment for TB and HIV infection is satisfactory.
  • Continuous therapy for 4 months or more provides positive clinical and X-ray changes in most patients; bacterial isolation ceases in 75%, and decay cavities close in 44% of cases.
  • Abacillation and cavity closures have been observed in 76.3 and 38% and 47 and 14% of cases in Groups 1 and 2, respectively.
  • Six-eight-month therapy with first-line drugs in combination with reserve ones in patients with pulmonary TB and HIV infection is well tolerated and highly effective.
  • A decision on the duration of anti-TB treatment for the HIV infected should be taken into account the program resources and the probability of refusing long-term therapy in 50% of cases.
  • In patients with HIV/TB, the rates are higher than those in patients with TB/HIV and are 19.2 and 14.5%, respectively.
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. Antitubercular Agents / therapeutic use. HIV. Tuberculosis / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Disease Progression. Female. Humans. Male. Radiography, Thoracic. Tuberculin Test


9. [EVALUATION OF THE EFFICIENCY OF TREATMENT AND THE CHOICE OF CONTROL COMPUTED TOMOGRAPHY TIME IN CHILDREN WITH MINOR FORMS OF INTRATHORACIC TUBERCULOSIS]. Tuberk Biolezni Legkih; 2010;(1):35-9
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  • [Title] [EVALUATION OF THE EFFICIENCY OF TREATMENT AND THE CHOICE OF CONTROL COMPUTED TOMOGRAPHY TIME IN CHILDREN WITH MINOR FORMS OF INTRATHORACIC TUBERCULOSIS].
  • Three chemotherapy regimens (Group 1: 2HRZ/4HR, n = 31; Group 2: 2HRZ/4HZ, n = 33; Group 3: 6HR, n = 33) were comparatively assessed in children with minor forms of intrathoracic tuberculosis diagnosed by the computed tomography (CT).
  • The leading criteria for therapeutic effectiveness were regression of intoxication symptoms and changes in the CT pattern.
  • The results of treatment were equal in all the groups.
  • CT pattern changes by months 2-3 and 6 of therapy were compared.
  • Single control CT investigation by 6 months of therapy was optimal.
  • Additional CT study at 2-3 months of therapy reflected positive changes in most cases, but failed to affect treatment policy.
  • [MeSH-major] Ethambutol. Isoniazid. Lymph Nodes / radiography. Pyrazinamide. Rifampin. Tuberculosis, Lymph Node. Tuberculosis, Pulmonary
  • [MeSH-minor] Antitubercular Agents / administration & dosage. Antitubercular Agents / adverse effects. Child. Child, Preschool. Comparative Effectiveness Research. Drug Monitoring / methods. Drug Therapy, Combination / methods. Female. Humans. Male. Outcome Assessment (Health Care). Thorax. Tomography, X-Ray Computed / methods

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  • (PMID = 27529929.001).
  • [ISSN] 2075-1230
  • [Journal-full-title] Tuberkulëz i bolezni lëgkikh
  • [ISO-abbreviation] Tuberk Biolezni Legkih
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antitubercular Agents; 2KNI5N06TI / Pyrazinamide; 8G167061QZ / Ethambutol; V83O1VOZ8L / Isoniazid; VJT6J7R4TR / Rifampin
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10. [SENSITIVITY OF THE NEW SKIN TEST DIASKINTEST® FOR THE DIAGNOSIS OF TUBERCULOSIS INFECTION IN CHILDREN AND ADOLESCENTS]. Tuberk Biolezni Legkih; 2010;(1):10-5
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  • [Title] [SENSITIVITY OF THE NEW SKIN TEST DIASKINTEST® FOR THE DIAGNOSIS OF TUBERCULOSIS INFECTION IN CHILDREN AND ADOLESCENTS].
  • In Russia, an intradermal Diaskintest® drug has been designed, which is a recombinant tuberculosis allergen based on M. tuberculosis-- specific proteins: ESAT-6 and CFP-10 produced by a genetically modified Escherichia coli culture.
  • The high percentage (83.8%) of positive responses to Diaskintest® is noted in children and adolescents with tuberculosis, receiving an intensive course of chemotherapy.
  • In the children who had completed treatment, positive tests were seen in 78.3%, moreover in those with prior tuberculosis of intrathoracic lymph nodes; negative tests were observed not earlier than 18 months after start of treatment.
  • The children with early primary tuberculosis infection, but in no family contact with bacteria-excreting individuals, showed a lower percentage of positive responses to Diaskintest® both before (37.5%) and after (10%) treatment, which suggests that there must be a lower bacterial burden in the child.
  • These were in only 16.7% in the group of patients receiving preventive therapy.
  • In children and adolescents with a persistent positive Mantoux test (for more than 3 years), the response to Diaskintest® was negative in most cases since in early infection when mycobacteria propagated, the reaction to the drug was positive, but as 3 years pass the probability of the infection transition to the persistence stage is high--at that time the response to Diaskintest® becomes negative.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Hypersensitivity, Delayed / diagnosis. Indicators and Reagents / pharmacology. Male. Reproducibility of Results. Russia / epidemiology. Sensitivity and Specificity

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  • (PMID = 27529924.001).
  • [ISSN] 2075-1230
  • [Journal-full-title] Tuberkulëz i bolezni lëgkikh
  • [ISO-abbreviation] Tuberk Biolezni Legkih
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / Bacterial Proteins; 0 / CFP-10 protein, Mycobacterium tuberculosis; 0 / ESAT-6 protein, Mycobacterium tuberculosis; 0 / Indicators and Reagents; 0 / Tuberculin
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11. Kevorkov NN, Gorovits GA, Bakhmet'ev SA: [Likopid in the complex immunomodulating treatment of patients with sarcoidosis of the lung and intrathoracic lymph nodes]. Ter Arkh; 2002;74(3):55-8
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  • [Title] [Likopid in the complex immunomodulating treatment of patients with sarcoidosis of the lung and intrathoracic lymph nodes].
  • AIM: To examine the functional status of the immune system in patients with lung and intrathoracic lymph nodes sarcoidosis and to evaluate the efficiency of immunomodulation alone and in its inclusion in combined treatment of the disease.
  • RESULTS: The optimal result (as long as 3-year remission) was achieved in the first time diagnosed sarcoidosis who have not taken glucocorticoidal hormones.
  • CONCLUSION: The follow-up shows that addition of licopid is a compulsory component of immunotherapy in this disease; the efficiency of treatment is determined by its multimodality.
  • The courses of therapy should be repeated when immunological indices deteriorated.
  • [MeSH-major] Acetylmuramyl-Alanyl-Isoglutamine / analogs & derivatives. Acetylmuramyl-Alanyl-Isoglutamine / therapeutic use. Adjuvants, Immunologic / therapeutic use. Lymph Nodes / pathology. Sarcoidosis / drug therapy
  • [MeSH-minor] Adult. Drug Therapy, Combination. Glucocorticoids / adverse effects. Glucocorticoids / therapeutic use. Humans. Middle Aged. Oligopeptides / therapeutic use. Peptides / therapeutic use. Plant Preparations / therapeutic use. Recurrence. Sarcoidosis, Pulmonary / drug therapy. Sarcoidosis, Pulmonary / immunology. Thorax. Thymus Extracts / therapeutic use. Vitamins / therapeutic use

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  • (PMID = 11980125.001).
  • [ISSN] 0040-3660
  • [Journal-full-title] Terapevticheskiĭ arkhiv
  • [ISO-abbreviation] Ter. Arkh.
  • [Language] rus
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Russia
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Glucocorticoids; 0 / Oligopeptides; 0 / Peptides; 0 / Plant Preparations; 0 / Thymus Extracts; 0 / Vitamins; 0 / glikopin; 0 / thymohexin; 53678-77-6 / Acetylmuramyl-Alanyl-Isoglutamine; 89492-35-3 / T-activin
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12. Parra ER, Canzian M, Saber AM, Coêlho RS, Rodrigues FG, Kairalla RA, de Carvalho CR, Capelozzi VL: Pulmonary and mediastinal "sarcoidosis" following surgical resection of cancer. Pathol Res Pract; 2004;200(10):701-5
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  • [Title] Pulmonary and mediastinal "sarcoidosis" following surgical resection of cancer.
  • Previous reports indicate that enlarged hilar and mediastinal lymph nodes caused by sarcoid-like reactions may develop after curative resection of cancer, and their presence does not necessarily denote neoplastic recurrence.
  • In this study, we describe two patients who had resected lung and gastric cancer and who later developed pulmonary interstitial infiltrate, concurrent with progressive mediastinal lymphadenopathy initially thought to be caused by intrathoracic dissemination of their cancer.
  • Thus, it is important to recognize this clinical pattern when pulmonary infiltrates develop after complete treatment of cancer in an otherwise relapse-free patient and to encourage lung or lymph node biopsy in these particular settings in order to confirm a sarcoid-like reaction, thereby avoiding unnecessary chemotherapy for presumed tumor recurrence.
  • [MeSH-minor] Aged. Diagnosis, Differential. Digestive System Surgical Procedures. Female. Granuloma / pathology. Humans. Lymph Nodes / pathology. Male. Middle Aged. Thoracic Surgical Procedures. Tomography, X-Ray Computed

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  • (PMID = 15648607.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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13. Werner-Wasik M, Xiao Y, Pequignot E, Curran WJ, Hauck W: Assessment of lung cancer response after nonoperative therapy: tumor diameter, bidimensional product, and volume. A serial CT scan-based study. Int J Radiat Oncol Biol Phys; 2001 Sep 1;51(1):56-61
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  • [Title] Assessment of lung cancer response after nonoperative therapy: tumor diameter, bidimensional product, and volume. A serial CT scan-based study.
  • PURPOSE: Tumor response after nonoperative lung cancer therapy is traditionally evaluated by bidimensional measurement of maximum tumor diameters.
  • The purpose of this analysis is to investigate whether tumor largest dimension (based on RECIST [Response Evaluation Criteria In Solid Tumors]), bidimensional tumor product, and volume correlate with each other in evaluating tumors of patients with locally advanced non-small-cell lung cancer (NSCLC).
  • In addition, the pace of locally advanced NSCLC volumetric response over time, as well as the prognostic value of tumor size, was assessed in this report with software-assisted evaluation of sequential tumor measurement.
  • METHODS AND MATERIALS: Patients with locally advanced NSCLC treated with thoracic radiotherapy (RT) with or without chemotherapy were included, if the following were available: a pretreatment computed tomography (CT) simulation and at least two follow-up diagnostic thoracic CT scans taken at our institution after 1996 that were available in Dicom format for electronic transfer of images from diagnostic radiology to a computer terminal with commercial statistics software (AcQsim/CMS Focus).
  • Primary lung tumor and grossly involved lymph nodes were contoured manually on pre-RT axial images and on all follow-up CT scans.
  • Tumor/lymph node largest dimensions, bidimensional products (BP), and volumes were measured using the same software.
  • The median thoracic RT dose was 62.4 Gy (range: 50.0-69.6), and all patients had a Karnofsky performance status > or =80.
  • Chemotherapy (mostly carboplatin/paclitaxel) was given to 17 patients.
  • A total of 107 thoracic CT scans (22 pretreatment and 85 follow-up), averaging 4.9 scans per patient, were analyzed.
  • Failure rates were as follows: in-field, 36% (8/22); intrathoracic (lung nodules, effusion, pleura), 55% (12/22); and distant, 50% (11/22).
  • Overall median survival time (MST) is 27.3 months.
  • At 24 months, 79% of patients with a tumor volume < or =124.0 cc (n = 18) had locally controlled tumors, vs. 0% of patients with tumor volumes >124.0 cc.
  • At the same time point, 93% of patients with BP < or =40 cm(2) were locally controlled, vs. 0% of those with BP > 40 cm(2); 100% of patients with tumor dimensions < or =7.5 cm were locally controlled, vs. 40% of those with dimensions >7.5 cm.
  • The partial responses in our series (assessed as the best response obtained during observation period) were as follows: 4 patients assessed based on either dimension only, product only, or volume only; 15 partial responses based on dimension or product; 16 partial responses based on volume alone; 3 cases of no tumor response, based on dimension or product; and 2 cases based on tumor volume alone.
  • (1) The response of locally advanced NSCLC to nonoperative therapy is a slow process, with tumor volumes reaching their nadir several months after treatment. (2) Smaller initial tumor size, as measured by largest tumor dimension, bidimensional product, or tumor volume, is associated with better local control and survival than larger initial measurements. (3) Any of the three tumor measurements (largest dimension, bidimensional product, or volume) can be used as a reliable tool in assessing lung cancer response to nonoperative therapy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / radiography. Carcinoma, Non-Small-Cell Lung / radiotherapy. Lung Neoplasms / radiography. Lung Neoplasms / radiotherapy. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 11516851.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Mitinskaia LA, Elufimova VF, Iukhimenko NV, Chernousova LN, Abdullaev RIu, Dem'ianenko NV, Baenskiĭ AV: [Diagnosis of latent primary intrathoracic tuberculosis of respiratory system in the phase of calcification in children]. Probl Tuberk Bolezn Legk; 2004;(1):16-20
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  • [Title] [Diagnosis of latent primary intrathoracic tuberculosis of respiratory system in the phase of calcification in children].
  • The paper shows the latent activity of newly diagnosed intrathoracic tuberculosis in the phase of calcification in children: clinical and X-ray changes, tuberculin sensitivity (Manteaux test), the presence of Mycobacterium tuberculosis (MBT) in the sputum and blood (cultivation, bacterioscopy, polymerase chain reaction PCR), the blood levels of acute-phase reagents: haptoglobin and alpha 1-protease inhibitor (alpha 1-PI), immunological parameters, tuberculosis antibodies (TAb), and MBT antigen.
  • Ninety children were examined before treatment.
  • Twenty-five children (Group 1) were found to have single minor calcified masses in one group of intrathoracic lymph nodes or in the lung.
  • Thirty-five children (Group 2) had multiple lymph nodes or foci in the lung in the phase of consolidation and calcification.
  • Thirty children (Group 3, controls) were diagnosed as having intrathoracic tuberculosis in the phase of infiltration.
  • Thus, MBT and TAb were revealed in 90% of the children in Group 3 and in 52.9 and 76.0% in Groups 1 and 2, respectively.
  • There were signs of intoxication in 80 and 88% and a hyperergic Mantoux reaction in 44.0 and 43.3%, respectively.
  • Thus, children with newly diagnosed respiratory tuberculosis in the phase of calcification should be regarded as having the signs of tuberculosis activity, followed up as Group I patients, and prescribed chemotherapy for 3-6 months or more, depending on the extent of the process.
  • [MeSH-major] Calcinosis / diagnosis. Mycobacterium tuberculosis / isolation & purification. Tuberculosis, Lymph Node / diagnosis. Tuberculosis, Pleural / diagnosis. Tuberculosis, Pulmonary / diagnosis


15. Nakahara O, Beppu T, Ishiko T, Mizumoto T, Masuda T, Hosaka S, Okabe H, Takamori H, Kanemitsu K, Hirota M, Baba H: [A long-term survival case of liver and mediastinal LN metastases from colon cancer treated with intensive multimodal therapy]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1792-4
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  • [Title] [A long-term survival case of liver and mediastinal LN metastases from colon cancer treated with intensive multimodal therapy].
  • A 50-year-old man with multiple liver and mediastinal LN metastases from sigmoid colon cancer was admitted to our hospital in May 2005.
  • He was treated with an oral anticancer agent as an adjuvant therapy.
  • In January 2005, the CEA level was increased to 3.2 ng/ml and CT scan revealed a solitary liver metastasis.
  • On admission to our hospital, a systemic chemotherapy by FOLFOX4 was begun.
  • The liver metastases showed 61% reduction in size and were judged to be PR.
  • However, the intrathoracic lymph node size was not changed.
  • Therefore, VATS extirpation of the mediastinal lymph node was performed.
  • He has been alive without any sign of recurrence for 42 months from the initial treatment.
  • In conclusion, intensive combination therapies for remote metastases of colon cancer might be promising to obtain a long-term survival without ruining QOL.
  • [MeSH-major] Colonic Neoplasms / pathology. Liver Neoplasms / secondary. Liver Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoembryonic Antigen / blood. Chemotherapy, Adjuvant. Combined Modality Therapy. Fluorouracil / therapeutic use. Hepatectomy. Humans. Leucovorin / therapeutic use. Lymphatic Metastasis. Male. Middle Aged. Organoplatinum Compounds / therapeutic use

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  • (PMID = 17212109.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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16. Xiao ZF, Yang ZY, Wang LH, Zhang HX, Feng QF, Chen DF, Zhou ZM, Zhang DC, Sun KL, Cheng GY, He J: [Influence of the number of lymph node metastasis on survival and significance of postoperative radiotherapy for esophageal carcinoma]. Zhonghua Zhong Liu Za Zhi; 2004 Feb;26(2):112-5
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  • [Title] [Influence of the number of lymph node metastasis on survival and significance of postoperative radiotherapy for esophageal carcinoma].
  • OBJECTIVE: To analyze the influence of the number of lymph node metastasis on survival and prophylactic postoperative radiotherapy after radical resection of thoracic esophageal carcinoma.
  • METHODS: Four hundred and ninety-five patients with thoracic esophageal squamous cell cancer who had undergone radical resection were randomly divided into surgery group alone (S, 275) and surgery plus radiotherapy group (S + R, 220).
  • The patients were classified into three groups: Group A: 234 patients (47.2%) without lymph node involvement; Group B: 146 patients (29.5%) with 1 to 2 involved lymph nodes and Group C: 115 patients (23.2%) with >or= 3 involved lymph nodes.
  • In the positive lymph node group, the metastatic rate of intra-thoracic and supraclavicular lymph node was 35.9% and 21.2% in S group and 19.7% and 4.4% in S+R group (P = 0.014 and P = 0.000).
  • In the negative lymph node group, the metastatic rates of intra-thoracic lymph node was 27.8% in S group and 10.3% in S + R group (P = 0.003).
  • The metastatic rate of intra-abdominal lymph node in Groups A, B and C was 3.9%, 9.4% and 17.5%, respectively (P = 0.0000).
  • The occurrence of hematogenous metastasis was most frequent in group C (27.8%) with >or= 3 positive lymph nodes.
  • The number of metastatic lymph node is one of the important factors which affects the survival of thoracic esophageal carcinoma.
  • 2. Chemotherapy might be given to the patients with three or more lymph nodes involved who have the possibility of developing hematogenous metastasis.
  • Postoperative radiotherapy can reduce the occurrence of intra-thoracic and supraclavicular lymph node metastasis and improve the survival of patients with three or more lymph nodes involvement.
  • [MeSH-major] Esophageal Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Survival Rate

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  • (PMID = 15059333.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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17. Fouzas I, Sotiropoulos GC, Sgourakis G, Drühe N, Wohlschlaeger J, Molmenti EP, Broelsch CE, Lang H: Five-year survival after monotherapy for hepatocellular carcinoma in the setting of cirrhosis. Transplant Proc; 2008 Nov;40(9):3204-5
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  • Sites of recurrence were the intrathoracic lymph nodes in the first case, and lungs in the second case.
  • Treatment of recurrence included chemotherapy in the first case and local resection in the second case.
  • Both patients died at 98 and 64 months postoperation (ie, 17 and 16 months, respectively, after the diagnosis of the recurrence).
  • Currently, 11 patients are alive with a median survival of 70 months (range, 63-144 months).
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Chemoembolization, Therapeutic. Liver Neoplasms / therapy. Liver Transplantation / statistics & numerical data
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Survival Rate. Survivors. Time Factors. alpha-Fetoproteins / analysis

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  • (PMID = 19010235.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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18. Mouroux J, Venissac N, Alifano M: Combined video-assisted mediastinoscopy and video-assisted thoracoscopy in the management of lung cancer. Ann Thorac Surg; 2001 Nov;72(5):1698-704
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  • [Title] Combined video-assisted mediastinoscopy and video-assisted thoracoscopy in the management of lung cancer.
  • BACKGROUND: This study seeks to assess the safety and usefulness of combined video-assisted mediastinoscopy and video-assisted thoracoscopy in the management of patients with lung cancer.
  • Indications for this combined approach included inconclusive findings from imaging techniques concerning locoregional extension and resectability; possible involvement of different structures not accessible to a single procedure; and failure to obtain histologic diagnosis by a single technique.
  • RESULTS; Histologic diagnosis was obtained in 6 patients without preoperative histologic typing.
  • In 3 patients, in contrast with preoperative imaging studies, combined thoracoscopy and mediastinoscopy showed the resectability of the primary tumor and the absence of metastatic mediastinal lymph nodes.
  • In 3 other patients prevascular lymph nodes metastases were found.
  • They underwent neoadjuvant chemotherapy; at subsequent operation, a complete resection was possible.
  • In the remaining four cases combined exploration proved definitive contraindications for operation (recognition of oat-cell carcinoma, n = 2; T4 status, n = 1; T3N2, n = 1).
  • Both the extent of primary tumor and the possible intrathoracic spread may be exhaustively evaluated.
  • In patients with left lung cancer a complete exploration of the aortopulmonary window is possible.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lung Neoplasms / surgery. Mediastinoscopy / methods. Thoracic Surgery, Video-Assisted

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  • (PMID = 11722067.001).
  • [ISSN] 0003-4975
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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19. [CAUSES OF CHRONIC TUBERCULOSIS OF INTRATHORACIC LYMPH NODES IN CHILDREN, THE SPECIFIC FEATURES OF CLINICAL MANIFESTATIONS AND THERAPY]. Tuberk Biolezni Legkih; 2010;(1):40-4
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  • [Title] [CAUSES OF CHRONIC TUBERCULOSIS OF INTRATHORACIC LYMPH NODES IN CHILDREN, THE SPECIFIC FEATURES OF CLINICAL MANIFESTATIONS AND THERAPY].
  • Studying the results of examination in 59 children with tuberculosis of intrathoracic lymph nodes over time could establish the main causes of the chronic course of the disease, reveal the specific features of clinical manifestations, and define the optimal regimens of specific therapy.
  • The chronic primary tuberculosis is characterized by a multiple intrathoracic lymph node lesion that corresponds to different phases of specific inflammation and is accompanied by complications in a third of cases.
  • Complex therapy lasted more than 10 months in 32.3% of cases and achieved recovery with insignificant residual changes in 69.5% of children.
  • The basic causes of chronic tuberculosis are untimely and inadequate prophylactic measures in risk groups and failures in early tuberculosis detection in children.
  • [MeSH-major] Antitubercular Agents / therapeutic use. Lymph Nodes / pathology. Tuberculosis, Lymph Node
  • [MeSH-minor] Child. Child, Preschool. Chronic Disease. Delayed Diagnosis / adverse effects. Delayed Diagnosis / prevention & control. Delayed Diagnosis / statistics & numerical data. Diagnostic Errors / prevention & control. Diagnostic Errors / statistics & numerical data. Drug Therapy, Combination / methods. Drug Therapy, Combination / statistics & numerical data. Female. Humans. Male. Outcome and Process Assessment (Health Care). Patient Acuity. Russia / epidemiology. Thorax. Time-to-Treatment

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  • (PMID = 27529930.001).
  • [ISSN] 2075-1230
  • [Journal-full-title] Tuberkulëz i bolezni lëgkikh
  • [ISO-abbreviation] Tuberk Biolezni Legkih
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antitubercular Agents
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20. Aboulafia DM: The epidemiologic, pathologic, and clinical features of AIDS-associated pulmonary Kaposi's sarcoma. Chest; 2000 Apr;117(4):1128-45
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  • Unlike classical forms of the disease, AIDS-associated KS is a multicentric entity that frequently involves lymph nodes and the GI tract.
  • The exact incidence of intrathoracic KS in patients with AIDS is unknown.
  • Before the advent of highly active antiretroviral therapy (HAART), pulmonary KS had been reported in approximately 10% of patients with AIDS, 25% of patients with cutaneous KS, and in roughly 50% of postmortem examinations of patients with AIDS, KS, and respiratory infections.
  • An aggressive diagnostic evaluation of patients who have this condition is essential because chemotherapy and radiation therapy may provide significant palliation, particularly if used in conjunction with HAART.
  • The pathology and pathogenesis of KS is also reviewed, along with the clinical and radiographic presentation, diagnosis, and management of pulmonary KS.


21. Vasil'ev VI, Sedyshev SKh, Radenska-Lopovok SG, Logvinenko OA, Simonova MV, Aleksandrova EN, Safonova TN, Fadienko GR, Varlamova EIu, Nasonov EL: [Renal insufficiency due to interstitial nephritis in sarcoidosis]. Ter Arkh; 2009;81(12):67-71
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  • The authors present their experience in diagnosing and treating interstitial nephritis with the development of chronic renal failure in a patient with generalized sarcoidosis, by involving the intrathoracic and peripheral lymph nodes, liver, spleen, subcutaneous fat, lung, as well as with the severe salivary and lachrymal gland lesions that imitate the clinical picture of Schogren's disease.
  • [MeSH-minor] Cyclophosphamide / administration & dosage. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Drug Administration Schedule. Drug Therapy, Combination. Humans. Male. Methylprednisolone / administration & dosage. Methylprednisolone / therapeutic use. Treatment Outcome. Young Adult

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  • (PMID = 20481054.001).
  • [ISSN] 0040-3660
  • [Journal-full-title] Terapevticheskiĭ arkhiv
  • [ISO-abbreviation] Ter. Arkh.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 8N3DW7272P / Cyclophosphamide; X4W7ZR7023 / Methylprednisolone
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22. Matsubara T, Ueda M, Kaisaki S, Kuroda J, Uchida C, Kokudo N, Takahashi T, Nakajima T, Yanagisawa A: Localization of initial lymph node metastasis from carcinoma of the thoracic esophagus. Cancer; 2000 Nov 1;89(9):1869-73
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  • [Title] Localization of initial lymph node metastasis from carcinoma of the thoracic esophagus.
  • BACKGROUND: Most surgeons consider esophageal carcinoma with lymph node involvement a systemic disease.
  • However, it is possible that the disease may be localized in the earlier phases of lymphatic metastasis.
  • The distribution of involved lesions in the initial phase of lymph node metastasis has not been thoroughly investigated yet.
  • METHODS: Among 329 patients that underwent curative (R0 International Union Against Cancer [UICC]) esophagectomy with systematic mesoesophageal dissection, 51 cases of patients with only 1 involved lymph node (solitary involvement) were retrospectively investigated and compared with patients with multiple involved lymph nodes.
  • The regional lymph nodes were divided into the thoracocervical junction group (lower deep cervical and recurrent nerve lymph nodes), perigastric group, and intrathoracic group.
  • RESULTS: Lymph node involvement was limited to a solitary lymph node in 46% of lymph node positive patients with esophageal carcinoma confined to the wall (T1 and T2, UICC) and in 17% of lymph node positive patients with cancer that invaded the extramural layer (T3 and T4, UICC).
  • Of patients with solitary involvement, 82% had a positive thoracocervical junction or perigastric lymph node.
  • The 5-year survival rate in solitary involvement cases was 61%, and 65% when solitary involvement was not intrathoracic.
  • Most of the 5-year survivors had involvement of a thoracocervical junction or perigastric lymph node and had not received systemic chemotherapy.
  • CONCLUSIONS: Solitary involvement was not rare and not directly associated with a disseminated disease.
  • Systematic dissection of the regional lymph nodes including thoracocervical junction and perigastric groups is recommended for resectable esophageal carcinoma at this time.
  • However, less extensive dissection may be performed in selected cases if the sentinel lymph node concept proves valid.
  • [MeSH-major] Esophageal Neoplasms / pathology. Lymphatic Metastasis
  • [MeSH-minor] Esophagectomy. Humans. Lymph Node Excision. Retrospective Studies. Sentinel Lymph Node Biopsy. Survival Rate. Thorax

  • MedlinePlus Health Information. consumer health - Esophageal Cancer.
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  • [Copyright] Copyright 2000 American Cancer Society.
  • (PMID = 11064342.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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23. Baryshnikova LA, Sukhov VM, Mel'nik LE: [Tuberculin sensitivity in children at the time of diagnosis of tuberculosis of intrathoracic lymph nodes]. Probl Tuberk; 2001;(1):37-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tuberculin sensitivity in children at the time of diagnosis of tuberculosis of intrathoracic lymph nodes].
  • Trends in RM with 2 TU PPD-L were analysed in 71 children at the time of detection of tuberculosis of intrathoracic lymph nodes (TITLN).
  • Monotonous tuberculin tests represent the most frequent variant of tuberculin allergy at the time of TITLN diagnosis in children.
  • [MeSH-major] Tuberculin / immunology. Tuberculin Test. Tuberculosis, Lymph Node / diagnosis
  • [MeSH-minor] Adolescent. Age Factors. Child. Child, Preschool. Female. Humans. Infant. Male. Risk Factors. Sex Factors. Time Factors

  • Genetic Alliance. consumer health - Tuberculosis.
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  • (PMID = 11337780.001).
  • [ISSN] 0032-9533
  • [Journal-full-title] Problemy tuberkuleza
  • [ISO-abbreviation] Probl Tuberk
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia
  • [Chemical-registry-number] 0 / Tuberculin
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