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1. Stabouli S, Sdougka M, Tsitspoulos P, Violaki A, Anagnostopoulos I, Tsonidis Ch, Koliouskas D: Primary atypical teratoid/rhabdoid tumor of the spine in an infant. Hippokratia; 2010 Oct;14(4):286-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary atypical teratoid/rhabdoid tumor of the spine in an infant.
  • Atypical teratoid/rhabdoid tumor of the spine is a rare pediatric neoplasm with poor prognosis.
  • We report a case of an atypical teratoid/rhabdoid tumor of the cervical spine in a 2-months-old infant.
  • Magnetic resonance imaging of the spinal cord revealed an intradural, extramedullary mass occupying the spinal canal on the right at the level of C1-C5.
  • Tumor cells were immunohistochemically positive for epithelial membrane antigen, vimentin, cytokeratins, S-100 protein, and CD57/Leu-7 antigen.
  • Despite chemotherapy, the infant presented with progressive neurological deterioration and died 6 months after initial diagnosis.
  • We review the literature on spinal malignant rhabdoid tumor and discuss the pathology, treatment, and outcome of these rare neoplasms.

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  • (PMID = 21311641.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC3031327
  • [Keywords] NOTNLM ; atypical teratoid tumor / chemotherapy / chromosome 22q / hydrocephalous / rhabdoid tumor / spine
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2. Yamashita T, Sakaura H, Oshima K, Iwasaki M, Yoshikawa H: Solitary intradural extramedullary lymphoma of the cervical spine. J Neurosurg Spine; 2010 Apr;12(4):436-9
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  • [Title] Solitary intradural extramedullary lymphoma of the cervical spine.
  • The authors report on the case of a 64-year-old man with solitary intradural extramedullary non-Hodgkin lymphoma of the cervical spine.
  • Positron emission tomography showed increased accumulation of fluorine-18-labeled fluorodeoxyglucose only in the cervical lesion.
  • At surgery, the intradural tumor in the subarachnoid space was totally extirpated.
  • Based on histopathological findings, diffuse, large B-cell type non-Hodgkin lymphoma was diagnosed.
  • Postoperatively, the patient was treated with 2 courses of chemotherapy by intrathecal injection of methotrexate, cytarabine, and prednisolone and 4 courses of intravenous rituximab, an antibody binding to CD20 on the surface of B cells.
  • To the best of the authors' knowledge, this case is the first reported instance of solitary intradural extramedullary non-Hodgkin lymphoma of the cervical spine.
  • [MeSH-major] Cervical Vertebrae. Lymphoma, B-Cell / diagnosis. Lymphoma, B-Cell / surgery. Spinal Neoplasms / diagnosis. Spinal Neoplasms / surgery
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Hormonal / administration & dosage. Chemotherapy, Adjuvant. Cytarabine / administration & dosage. Fluorodeoxyglucose F18. Humans. Injections, Intravenous. Injections, Spinal. Magnetic Resonance Imaging. Male. Methotrexate / administration & dosage. Middle Aged. Positron-Emission Tomography. Prednisolone / administration & dosage. Radiopharmaceuticals. Rituximab. Treatment Outcome

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  • (PMID = 20367381.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Hormonal; 0 / Radiopharmaceuticals; 04079A1RDZ / Cytarabine; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 4F4X42SYQ6 / Rituximab; 9PHQ9Y1OLM / Prednisolone; YL5FZ2Y5U1 / Methotrexate
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3. Lee CH, Moon KY, Chung CK, Kim HJ, Chang KH, Park SH, Jahng TA: Primary intradural extramedullary melanoma of the cervical spinal cord: case report. Spine (Phila Pa 1976); 2010 Apr 15;35(8):E303-7
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  • [Title] Primary intradural extramedullary melanoma of the cervical spinal cord: case report.
  • OBJECTIVE: We report a case of primary intradural extramedullary melanoma of the cervical spinal cord in a nonwhite patient.
  • Primary malignant melanoma of the spinal cord is a rare disease entity that predominately affects the middle or lower thoracic spine.
  • RESULTS: A standard posterior midline approach was used under the impression that the subacute subdural hematoma was caused by a hidden vascular anomaly or a rare, intradural, pigmented tumor.
  • A dark black-colored, hard, intradural mass was found, and gross total removal was performed.
  • Subsequent radiotherapy and chemotherapy were administered.
  • CONCLUSION: Unlike most cases of primary intradural melanoma, this patient presented with unusual radiologic findings in the cervical spinal cord.
  • The case described in the present study illustrates that primary spinal cord melanoma is rare and must be diagnosed with caution due to its variable clinical and radiologic presentation.
  • [MeSH-major] Melanoma / pathology. Melanoma / therapy. Spinal Cord Compression / etiology. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Activities of Daily Living. Adult. Asian Continental Ancestry Group. Biomarkers, Tumor. Combined Modality Therapy. Decompression, Surgical. Diagnosis, Differential. Drug Therapy. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Muscle Weakness / etiology. Neurosurgical Procedures. Paresthesia / etiology. Positron-Emission Tomography. Radiotherapy. Spinal Cord / pathology. Spinal Cord / physiopathology. Spinal Cord / surgery. Treatment Outcome

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  • (PMID = 20308942.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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4. Heran NS, Yong RL, Heran MS, Yip S, Fairholm D: Primary intradural extraarachnoid hodgkin lymphoma of the cervical spine. Case report. J Neurosurg Spine; 2006 Jul;5(1):61-4
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  • [Title] Primary intradural extraarachnoid hodgkin lymphoma of the cervical spine. Case report.
  • This 42-year-old man presented with an intradural extramedullary mass in his lower cervical spine.
  • At surgery, the mass was found to be an intradural extra-arachnoid tumor.
  • The procedure was limited to biopsy sampling and the patient was treated further with adriamycin, bleomycin, vincristine, and dacarbazine chemotherapy, after which remission was demonstrated both clinically and on images.
  • Analysis of a frozen section obtained during the procedure aided in the diagnosis of the tumor, thus preventing further resection and the potential neurological complications associated with more radical resection.
  • To the authors' knowledge this is the first reported case of a presumed primary intradural extraarachnoid Hodgkin lymphoma.
  • [MeSH-major] Hodgkin Disease / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 16850958.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Nakadate M, Harad M, Isobe H: [Clinical features of intradural spinal cord metastases in primary lung cancer]. Nihon Kokyuki Gakkai Zasshi; 2005 Sep;43(9):541-6
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  • [Title] [Clinical features of intradural spinal cord metastases in primary lung cancer].
  • We retrospectively investigated the clinical features of 9 consecutive cases of intradural spinal cord metastasis from primary lung cancer treated at our hospital between April 1999 and March 2002.
  • During those three years, spinal cord metastasis was diagnosed in seven of 49 (14.3%) cases with small cell carcinoma and only two of 284 (0.7%) cases with non-small cell carcinoma.
  • Eight of the 9 cases had concomitant brain metastasis that preceded spinal cord metastasis and had received brain irradiation.
  • The interval from brain irradiation to the diagnosis of spinal cord metastasis ranged from 116 to 708 days (median 183 days).
  • Seven of the patients rapidly developed transverse myelopathy within two weeks.
  • Magnetic resonance imaging (MRI) with contrast enhancement demonstrated intramedullary tumors in seven cases and intradural extramedullary tumors in two cases.
  • Spinal cord metastasis was often multifocal, and in each case lumbar enlargement was commonly involved.
  • Radiation therapy with or without concurrent chemotherapy produced both neurologic improvement and a tumor response shown on MRI in 4 patients.
  • Heightened awareness of the increasing incidence and background risk factors of this unusual complication could lead to earlier diagnosis and more effective treatment for neurologic palliation.
  • [MeSH-major] Lung Neoplasms / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / secondary

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  • (PMID = 16218424.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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6. Biswas A, Puri T, Goyal S, Gupta R, Eesa M, Julka PK, Rath GK: Spinal intradural primary germ cell tumour--review of literature and case report. Acta Neurochir (Wien); 2009 Mar;151(3):277-84

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  • [Title] Spinal intradural primary germ cell tumour--review of literature and case report.
  • BACKGROUND: Primary spinal cord germ cell tumour is a rare tumour.
  • We herein review the tumour characteristics, associated risk factors, treatment policy, and patterns of failure of primary intradural germ cell tumour.
  • METHOD: We conducted a PUBMED search using a combination of keywords such as "spinal germ cell tumor," "germinoma," "extradural," "intradural," "intramedullary," "extramedullary," and identified 19 cases of primary spinal germ cell tumour.
  • Clinical features, pathologic characteristics, and treatment details of these patients including status at follow-up were noted from respective case reports.
  • We also describe a case of a young Indian patient of intradural extramedullary germ cell tumour treated with a combination of surgery, chemotherapy, and radiotherapy.
  • Most patients were treated with a combination of surgery, radiation therapy, and systemic chemotherapy.
  • Magnetic resonance imaging spine showed an inhomogeneous hyperintense soft tissue mass at L(2)-L(4) spinal level.
  • He was treated with complete surgical excision and four cycles of chemotherapy with BEP regimen following a histological diagnosis of non-seminomatous germ cell tumour.
  • CONCLUSION: Limited surgery followed by upfront radiation therapy and adjuvant chemotherapy is the optimal management of this rare group of tumour.
  • Omission of radiation therapy from the treatment armamentarium might engender local recurrence and spinal dissemination at first failure.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / therapy. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Chorionic Gonadotropin, beta Subunit, Human / analysis. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Decompression, Surgical. Disease Progression. Fatal Outcome. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Myelitis, Transverse / etiology. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / radiotherapy. Neurosurgical Procedures. Radiotherapy. Subarachnoid Space / pathology. Subarachnoid Space / surgery

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  • [CommentIn] Acta Neurochir (Wien). 2009 Aug;151(8):983-4 [19337687.001]
  • (PMID = 19240975.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
  • [Number-of-references] 41
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7. Haresh KP, Chinikkatti SK, Prabhakar R, Rishi A, Rath GK, Sharma DN, Julka PK: A rare case of intradural extramedullary Ewing's sarcoma with skip metastasis in the spine. Spinal Cord; 2008 Aug;46(8):582-4
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  • [Title] A rare case of intradural extramedullary Ewing's sarcoma with skip metastasis in the spine.
  • BACKGROUND: Spinal cord tumors are rare and fortunately affect only a minority of the population.
  • These tumors are classified based on their anatomic location in relation to the dura mater and spinal cord as epidural, intradural extramedullary or intradural intramedullary.
  • Intradural extramedullary Ewing's sarcoma is extremely rare.
  • PURPOSE: Here, we are reporting a case of intradural extramedullary Ewing's sarcoma.
  • METHODS: A 26-year-old gentleman presented to us with low backache and progressive paraparesis from a spinal tumor.
  • Magnetic resonance imaging showed multiple intradural, extramedullary mass lesions extending from the T11 to S2 level.
  • He was treated by surgery, local radiotherapy and chemotherapy.
  • Two months after treatment, he developed a new skip lesion in the spine at T6-T7 level.
  • The new lesion was treated with local radiotherapy and chemotherapy.
  • RESULTS: Presently, the patient has completed treatment and is clinically doing fine.
  • CONCLUSION: Intradural extramedullary Ewing's sarcoma is a rare aggressive neoplasm with high propensity for skip metastasis.
  • [MeSH-major] Bone Neoplasms / secondary. Sarcoma, Ewing / secondary. Spinal Cord Neoplasms / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Adult. Decompression, Surgical / methods. Dura Mater / pathology. Dura Mater / surgery. Humans. Laminectomy / methods. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed / methods

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  • (PMID = 18268515.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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8. Raza SM, Anderson WS, Eberhart CG, Wolinsky JP, Gokaslan ZL: The application of surgical cordectomy in the management of an intramedullary-extramedullary atypical meningioma: case report and literature review. J Spinal Disord Tech; 2005 Oct;18(5):449-54
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  • [Title] The application of surgical cordectomy in the management of an intramedullary-extramedullary atypical meningioma: case report and literature review.
  • BACKGROUND: The English literature describes only four cases of intraspinal tumors requiring surgical intervention in the form of cordectomy; none of these cases was for meningiomas.
  • Intraspinal meningiomas, typically extramedullary-intradural, require treatment in the form of resection with dural margin excision.
  • The authors report a case of a transformed intramedullary-extramedullary atypical meningioma treated with cordectomy.
  • METHODS: The patient was a 65-year-old woman who presented with a recurrent thoracic meningioma status post three attempted resections, radiation therapy, and a trial of hydroxyurea chemotherapy.
  • CONCLUSIONS: This case highlights the viability of surgical cordectomy in the treatment of varying intramedullary processes under appropriate indications.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Spinal Cord / surgery

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  • (PMID = 16189459.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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9. Grimm S, Chamberlain MC: Adult primary spinal cord tumors. Expert Rev Neurother; 2009 Oct;9(10):1487-95

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  • [Title] Adult primary spinal cord tumors.
  • Primary spinal cord tumors represent 2-4% of all neoplasms of the CNS.
  • Primary spinal cord tumors are anatomically separable into two broad categories: intradural intramedullary and intradural extramedullary.
  • Intramedullary tumors are comprised predominantly of gliomas (infiltrative astrocytomas and ependymomas).
  • Resective surgery can usually be accomplished with spinal ependymomas owing to separation of tumor from spinal cord and, when complete, require no further therapy.
  • By contrast, spinal cord gliomas infiltrate the myelon and, consequently, surgery is nearly always incomplete.
  • Intradural extramedullary tumors are either peripheral nerve sheath tumors (neurofibromas or schwanommas) or meningiomas.
  • Chemotherapy is administered for recurrent primary spinal cord tumors without other options, that is, reoperation or re-irradiation.
  • Problematic, however, is the lack of clinical trials in general for these CNS tumors and for spinal cord tumors in particular.
  • Consequently, treatment is similar to that for intracranial tumors with a similar histology.
  • Early recognition of the signs and symptoms of primary spinal cord tumors allows for early treatment, potentially minimizes neurologic morbidity and improves outcome.
  • Primary treatment is surgery in essentially all spinal cord tumors, and predictors of outcome include preoperative functional status, histological grade of tumor and extent of surgical resection.
  • [MeSH-major] Spinal Cord Neoplasms / classification. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Neurosurgical Procedures. Young Adult

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  • (PMID = 19831838.001).
  • [ISSN] 1744-8360
  • [Journal-full-title] Expert review of neurotherapeutics
  • [ISO-abbreviation] Expert Rev Neurother
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 82
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10. Tekkök IH, Sav A: Aggressive spinal germinoma with ascending metastases. J Neurooncol; 2005 Nov;75(2):135-41
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  • [Title] Aggressive spinal germinoma with ascending metastases.
  • Initial spinal MR scans showed a sausage-like lesion that extended between L1 and S2.
  • At surgery, an encapsulated intradural extramedullary tumor was removed en bloc.
  • The tumor recurred locally to double its original size only 4 months later.
  • After second surgery, 5,100 cGy of local spinal radiation was given since the pathologist believed that the new tumor exhibited anaplastic features.
  • Subsequently tumor recurred at T6-10 levels and later in the right parasellar region.
  • At 11 months after the initial presentation, a new tumor was diagnosed at T11-T12 levels.
  • After fifth surgery, chemotherapy with cisplatin, doxorubicin and vincristine was started.
  • A new chemotherapy regimen targeted for germinoma was then started.
  • Primary spinal germinomas are exceedingly rare.
  • A review of the literature revealed only 14 biopsy-proven spinal germinoma cases.
  • Our case is clearly unique in aggressivity of the tumor, a feature often unexpected for germinomas.
  • This case proves that the dissemination risk may be very serious for germinomas and that the craniospinal radiation may be a more secure treatment mode.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / pathology. Neoplasm Recurrence, Local / diagnosis. Reoperation. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Ependymoma / diagnosis. Follow-Up Studies. Humans. Lumbar Vertebrae / anatomy & histology. Magnetic Resonance Imaging. Male. Sacrum / anatomy & histology. Time Factors. Treatment Outcome

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  • (PMID = 16132516.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Kotil K, Kilinc BM, Bilge T: Spinal metastasis of occult lung carcinoma causing cauda equina syndrome. J Clin Neurosci; 2007 Apr;14(4):372-5
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  • [Title] Spinal metastasis of occult lung carcinoma causing cauda equina syndrome.
  • Cauda equina syndrome (CES) may be caused by tumor, herniated disc, trauma and spinal infections.
  • A 50-year-old man presented with a subacute CES caused by an intradural metastasis of an adenocarcinoma of the lung to the lumbosacral cauda fibers.
  • His lumbosacral magnetic resonance imaging (MRI), showed a well-demarcated, intradural extramedullary mass lesion resembling a neurinoma at the L4/5 level.
  • The operative findings were also suggestive of neurinoma with involvement of three nerve roots, and a well-demarcated tumor without infiltration into the subarachnoid space.
  • Chest X-ray and high resolution contrasted pulmonary computed tomography were normal.
  • Positron emission tomography (PET) showed a lung mass, at the left apex.
  • The patient was treated with chemotherapy and post-operative spinal radiotherapy was also performed.
  • MRI of intradural cauda equina metastasis may be similar to that of intradural nerve sheath tumor.
  • Surgery and postoperative radiotherapy may be effective for the treatment of CES due to lung carcinoma.
  • Definitive diagnosis is by histopathological examination with immunohistochemistry.
  • [MeSH-major] Adenocarcinoma, Clear Cell / secondary. Lung Neoplasms / pathology. Peripheral Nervous System Neoplasms / secondary. Polyradiculopathy / etiology
  • [MeSH-minor] Humans. Male. Middle Aged. Positron-Emission Tomography. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / secondary. Spinal Cord Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17336230.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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12. Chowdhury AZ, Hossain MT, Chowdhury AI, Salek KM, Kaiser MS, Arifin KN: Evaluation of surgical management of primary spinal tumours. Mymensingh Med J; 2010 Oct;19(4):594-600

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of surgical management of primary spinal tumours.
  • Spinal tumours, which are 5-10% of skeletal tumours, cause considerable morbidity and present challenging situations in their management.
  • Surgery is often used in the treatment of spinal tumours.
  • Now a day only few specialized spinal care centers have developed in Bangladesh.
  • The prospective study regarding surgical management of primary spinal tumour might be beneficial for proper planning and patient management.
  • All patients who underwent surgical resection of a primary tumor of the spine between July 2006 and May 2008, at the Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
  • There were 8(25%) vertebral body and pedicle tumors and 3(9.37%) extradural, 16(50%) intradural-extramedullary and 05(15.67%) intradural intramedullary.
  • Only 5(15.63%) developed complication.
  • In addition to surgery, radiotherapy and chemotherapy are needed to sterilize the tumour bed.
  • Early detection and surgery of primary spinal tumour give satisfactory results and patient can return to their normal life.

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  • (PMID = 20956905.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Bangladesh
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13. Jalali K, Chautard D, Racineux P, Pabot du Chatelard P: [Spinal cord metastasis from prostate cancer]. Prog Urol; 2004 Sep;14(4):554-7; discussion 557
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  • [Title] [Spinal cord metastasis from prostate cancer].
  • The majority of spinal cord lesions observed in prostate cancer are related to extradural compression.
  • Intradural (extramedullary or intramedullary) metastases are very rare.
  • Despite endocrine therapy initiated immediately after diagnosis, the patient rapidly developed leg pain due to vertebral osteolysis.
  • He developed flaccid paraplegia despite radiotherapy of the lumbar spine combined with corticosteroid therapy and chemotherapy.
  • Spinal cord magnetic resonance imaging (MRI) showed typical features of very probable carcinomatous myelitis in the cervicothoracic zone.
  • Regardless of the primary cancer, intramedullary spinal cord metastases have a very poor prognosis.
  • [MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Spinal Neoplasms / secondary

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  • (PMID = 15776912.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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14. Kodama H, Maeda M, Imai H, Matsubara T, Taki W, Takeda K: MRI of primary spinal atypical teratoid/rhabdoid tumor: a case report and literature review. J Neurooncol; 2007 Sep;84(2):213-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI of primary spinal atypical teratoid/rhabdoid tumor: a case report and literature review.
  • Primary spinal atypical teratoid/rhabdoid tumor (AT/RT) is extremely rare.
  • Subsequent MRI showed an intradural extramedullary bulky mass extending from C4 to T6.
  • Subtotal removal of the tumor was performed and spinal AT/RT was proven histologically.
  • Despite chemotherapy and radiation therapy, leptomeningeal dissemination was found on follow-up MRI.
  • [MeSH-major] Rhabdoid Tumor / pathology. Spinal Neoplasms / pathology. Teratoma / pathology

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  • [Cites] Clin Imaging. 1999 Nov-Dec;23(6):356-60 [10899417.001]
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  • (PMID = 17361332.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


15. Yavuz AA, Yaris N, Yavuz MN, Sari A, Reis AK, Aydin F: Primary intraspinal primitive neuroectodermal tumor: case report of a tumor arising from the sacral spinal nerve root and review of the literature. Am J Clin Oncol; 2002 Apr;25(2):135-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary intraspinal primitive neuroectodermal tumor: case report of a tumor arising from the sacral spinal nerve root and review of the literature.
  • Primary spinal primitive neuroectodermal tumor (PNET) is a rare condition, 18 cases of which have been reported in the literature.
  • In general, this tumor is treated with surgery followed by radiotherapy and chemotherapy, but prognosis is still poor.
  • An 18-year-old female patient with an intradural, extramedullary mass at L3-L5 levels is presented in this report.
  • This is the first female patient with primary spinal PNET at lumbar region, second patient with spinal nerve root origin, and third one with intradural, extramedullary localization ever reported in the literature.
  • After surgery, she was treated with craniospinal radiotherapy and four cycles of combination chemotherapy regimen consisting of vincristine, cyclophosphamide, doxorubicin alternated with ifosfamide, and VP-16.
  • [MeSH-major] Neuroectodermal Tumors, Primitive. Spinal Cord Neoplasms
  • [MeSH-minor] Adolescent. Combined Modality Therapy. Female. Humans. Lumbar Vertebrae. Spinal Nerve Roots

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  • (PMID = 11943890.001).
  • [ISSN] 0277-3732
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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16. Kan P, Gottfried ON, Blumenthal DT, Liu JK, Salzman KL, Townsend J, Jensen RL: Primary spinal yolk sac tumor with brain metastasis: case report and review of the literature. J Neurooncol; 2006 Jul;78(3):249-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal yolk sac tumor with brain metastasis: case report and review of the literature.
  • OBJECT: Central nervous system primary germ cell tumors are typically pineal or suprasellar.
  • Primary germ cell tumors of the spinal axis are very rare, with only a few case reports of germinomas and teratomas described in the literature.
  • METHODS: We present the unique case of a 25-year-old woman with an intradural, extramedullary primary yolk sac tumor (YST) at and below the level of the conus medullaris.
  • She was subsequently treated with four cycles of chemotherapy (intravenous cisplatin and etoposide), 40-Gy fractionated focal external beam radiation to the spine, and consolidation with four additional cycles of chemotherapy (intravenous carboplatin, vinblastine, etoposide, and bleomycin).
  • Despite an initial reduction in tumor size and clinical improvement in her neurologic exam, she re-presented a year after surgery with gross enlargement of her spinal tumor and CSF dissemination with metastasis to her brain.
  • Despite further chemotherapy and radiotherapy, the patient died from her disseminated YST.
  • When feasible (no evidence of CSF dissemination, metastasis, or multifocal disease), optimal treatment includes as extensive resection of tumor as possible followed by adjuvant chemotherapy and radiation.
  • The authors review the available literature on the treatment of intracranial malignant germ cell tumors, extrapolated to apply to the much rarer spinal lesions.
  • [MeSH-major] Brain Neoplasms / secondary. Endodermal Sinus Tumor / secondary. Neoplasm Recurrence, Local / pathology. Spinal Neoplasms / pathology

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  • (PMID = 16773223.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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17. Lacoste-Collin L, Roux FE, Gomez-Brouchet A, Despeyroux ML, Uro-Coste E, Coindre JM, Delisle MB: Inflammatory myofibroblastic tumor: a spinal case with aggressive clinical course and ALK overexpression. Case report. J Neurosurg; 2003 Mar;98(2 Suppl):218-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inflammatory myofibroblastic tumor: a spinal case with aggressive clinical course and ALK overexpression. Case report.
  • The authors report on a case of spinal inflammatory myofibroblastic tumor (IMT) in a 22-year-oldwoman.
  • Neuroradiological features of this intradural extramedullary mass were suggestive of a meningioma or neurinoma.
  • The patient's postoperative course was complicated by a multifocal local recurrence requiring a second surgery, which was followed by radio- and chemotherapy.
  • The occurrence of IMT in the spinal cord has rarely been reported.
  • This has been recently reported in this tumor typein other locations.
  • [MeSH-major] Fibroblasts / pathology. Muscle, Smooth / pathology. Protein-Tyrosine Kinases / metabolism. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / enzymology

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  • (PMID = 12650409.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
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18. Nagashima T, Mori M, Fujimoto M, Nunomura M, Sakurai Y, Okada Y, Itoh T, Sawa H, Stan AC, Nagashima K: Adult T-cell lymphoma involving the leptomeninges associated with a spinal cord schwannoma. Neuropathology; 2001 Sep;21(3):229-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult T-cell lymphoma involving the leptomeninges associated with a spinal cord schwannoma.
  • An autopsy case of ATL-L with an acute onset of meningitis and generalized lymphadenopathy in association with a cervical cord schwannoma is reported here.
  • A 78-year-old woman with sensori-motor weakness of both arms over a 1-year period, developed febrile episodes and drowsiness with neck stiffness.
  • Biopsy of an enlarged retroperitoneal lymph node revealed malignant lymphoma of the T-cell type.
  • Brain MRI was negative, whereas an intradural extramedullary mass was found at the C4 level.
  • With a diagnosis of ATL-L stage IV, chemotherapy was commenced, which was effective in reducing the generalized lymphadenopathy as well as the cervical mass and restoring the CSF findings to normality.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Meningeal Neoplasms / pathology. Neurilemmoma / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD / metabolism. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cervical Vertebrae. Deltaretrovirus Antibodies / metabolism. Female. Human T-lymphotropic virus 1 / immunology. Human T-lymphotropic virus 1 / pathogenicity. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Treatment Outcome

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  • (PMID = 11666021.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Deltaretrovirus Antibodies
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19. Bohner G, Masuhr F, Distl R, Katchanov J, Klingebiel R, Zschenderlein R, von Deimling A, van Landeghem FK: Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. Acta Neuropathol; 2005 Sep;110(3):306-11
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  • Spinal magnetic resonance imaging showed extended intradural, extramedullary, contrast-enhancing masses with compression of the myelon.
  • Spinal leptomeningeal biopsy revealed a pilocytic astrocytoma WHO grade I.
  • Despite chemotherapy with vincristin and carboplatin, the patient died 2 months after admission.
  • A thorough autopsy showed no evidence for primary neoplasms in brain, spine and optic nerve.
  • Sequence analysis of tumor protein 53 gene (TP53) revealed a missense mutation in exon 5, and expression of phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN) protein was not detected, which may have contributed to astrocytoma development.
  • To our knowledge, this is the first definitive case of pilocytic astrocytoma presenting as PDLG.
  • [MeSH-major] Astrocytoma / pathology. Meningeal Neoplasms / pathology. Meninges / pathology. Neoplasms, Neuroepithelial / pathology. Neoplasms, Unknown Primary / pathology. Subarachnoid Space / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / genetics. Brain / pathology. Brain / physiopathology. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Mutation / genetics. Spinal Cord / pathology. Spinal Cord / physiopathology. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Cord Compression / physiopathology. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 16003541.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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20. O'Toole O, O'Hare A, Grogan L, Bolger C, Brett FM: 20 year old lady with a paraspinal mass. Brain Pathol; 2010 May;20(3):683-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MRI revealed a right-sided intradural extramedullary mass extending from C7-T1 and displacing the spinal cord.
  • She was re-imaged and the lesion now extended from C5 to T3 with spinal cord compression at C7-T1.
  • The patient underwent emergency resection of the lesion and pathology revealed Hodgkin's Lymphoma (HL)-mixed cellularity type.
  • The patient is currently undergoing treatment with ABVD chemotherapy.
  • Lesions may be parenchymal or dural based and are usually intracranial with an increased risk of CNS involvement in HL-mixed-cellularity type as in our patient.
  • [MeSH-major] Cervical Vertebrae / pathology. Hodgkin Disease / pathology. Spinal Canal / pathology. Spinal Cord Neoplasms / pathology. Spinal Neoplasms / pathology

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  • (PMID = 20522095.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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21. Nutman A, Postovsky S, Zaidman I, Elhasid R, Vlodavsky E, Kreiss Y, Ben Arush MW: Primary intraspinal primitive neuroectodermal tumor treated with autologous stem cell transplantation: case report and review of the literature. Pediatr Hematol Oncol; 2007 Jan-Feb;24(1):53-61
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  • [Title] Primary intraspinal primitive neuroectodermal tumor treated with autologous stem cell transplantation: case report and review of the literature.
  • The authors describe the case of a 19-year-old female patient with a primary primitive neuroectodermal tumor (PNET) of the thoraco-lumbar spinal cord, who presented with acute urinary retention and back pain for 2 months.
  • Magnetic resonance imaging revealed an intradural extramedullary tumor, 6.5 cm long, in the region of the conus medullaris.
  • Histological examination disclosed a small round cell tumor with immunohistochemical characteristics of a peripheral PNET.
  • Metastatic workup showed no evidence of an intracranial tumor or metastases outside the neuroaxis.
  • The patient received multidisciplinary treatment, including surgical excision, irradiation of the entire cranio-spinal axis, and high-dose chemotherapy with autologous stem cell rescue.
  • [MeSH-major] Neuroectodermal Tumors, Primitive / therapy. Spinal Neoplasms / therapy. Stem Cell Transplantation
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Laminectomy. Transplantation, Autologous

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  • (PMID = 17130114.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 16
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22. Bydon A, Gutierrez JA, Mahmood A: Meningeal melanocytoma: an aggressive course for a benign tumor. J Neurooncol; 2003 Sep;64(3):259-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meningeal melanocytoma: an aggressive course for a benign tumor.
  • Magnetic resonance imaging (MRI) revealed a large T8-T9 intraspinal tumor.
  • She underwent a thoracic laminectomy, and excision of an intradural extramedullary lesion.
  • The surgical specimen was soft, black tissue that consisted of a moderately cellular, deeply pigmented tumor.
  • On repeat imaging, there was nodular enhancement of the fourth ventricle and throughout the spinal cord.
  • Despite chemotherapy and radiation therapy, the disease advanced and the patient expired.
  • Meningeal melanocytoma is a rare, histologically benign tumor with good prognosis.
  • In this report, we present an unusual case of spinal meningeal melanocytoma with diffuse spread throughout the craniospinal axis that proved to be fatal.
  • [MeSH-major] Brain Neoplasms / secondary. Cerebral Ventricle Neoplasms / secondary. Melanoma / pathology. Meningeal Neoplasms / pathology. Spinal Neoplasms / diagnosis

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  • (PMID = 14558602.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


23. Castadot P, Magné N, Roelandts M, Gastelblum P, Oulad Ben Taib N, Van Houtte P: [Metastasis of a lumbosacral ependymoma with very long disease-free survival: a case report and review of the literature]. Cancer Radiother; 2006 May;10(3):148-51
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  • The lumbosacral location of spinal ependymoma is the most common.
  • Six months later, the patient's symptoms reappeared and an external radiotherapy at curative doses and chemotherapy were delivered.
  • Complete imaging study concluded to a cervical extramedullary intradural tumour and to the persistence of the primary lumbosacral tumour.
  • External radiotherapy was delivered on this site with a total dose of 50 Gy.
  • [MeSH-major] Ependymoma / therapy. Neoplasm Recurrence, Local / therapy. Spinal Cord Neoplasms / rehabilitation
  • [MeSH-minor] Adolescent. Cervical Vertebrae. Disease-Free Survival. Humans. Lumbar Vertebrae. Male. Sacrum. Time Factors

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  • (PMID = 16581282.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 25
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24. Kiwerski JE: Surgery and subsequent rehabilitation for cervical spine tumours compressing neural structures. Ortop Traumatol Rehabil; 2008 Nov-Dec;10(6):620-5
MedlinePlus Health Information. consumer health - Neck Injuries and Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, the cervical spine is also the site of benign tumours and neoplasms involving not only bony tissue.
  • Benign tumours do not metastasize but pose a threat to the spinal cord when located intrathecally.
  • The most common cervical spine neoplasms are intradural tumours, usually extramedullary: neurofibromas, meningiomas or gliomas.Indications for surgery depend of the nature and location of the tumour and the consequences of tumour growth.
  • Surgery is obviously necessary for intrathecal tumours compressing the spinal cord.
  • The choice of surgical approach and manner of stabilisation depend primarily on the location of the lesion and the presence of spinal cord compression.Rehabilitation is indicated in all patients, but is particularly important, and at the same time difficult, when the growth of the tumour has resulted in neurological disturbances.
  • The task is all the more difficult when in the presence of a massive and high spinal cord damage.
  • Rehabilitation programmes should be designed individually for each patient and should account for the degree of paresis, stage of the underlying malignant disease, survival prognosis, disturbances in the function of other systems, apart from musculoskeletal apparatus, age of the patient, his or her commitment to treatment and other factors.The treatment of malignant neoplasms is usually associated with an unfavourable outcome.
  • However, combination drug treatments, radiation therapy and surgery with subsequent rehabilitation will often prolong survival, ameliorate suffering and improve patients' quality of life.
  • [MeSH-major] Cervical Vertebrae / surgery. Paresis / rehabilitation. Spinal Cord Compression / etiology. Spinal Neoplasms / complications. Spinal Neoplasms / surgery

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  • (PMID = 19274865.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng; pol
  • [Publication-type] Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 16
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25. Adamson DC, Cummings TJ, Friedman AH: Malignant peripheral nerve sheath tumor of the spine after radiation therapy for Hodgkin's lymphoma. Clin Neuropathol; 2004 Sep-Oct;23(5):245-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant peripheral nerve sheath tumor of the spine after radiation therapy for Hodgkin's lymphoma.
  • We report the development of a malignant peripheral nerve sheath tumor (MPNST) in 2 patients after irradiation for Hodgkin's lymphoma.
  • Clinicians should be aware of this uncommon, but important fatal complication of radiation therapy.
  • She did well with extensive radiotherapy until 5 years later when she developed severe right arm and chest pain secondary to recurrent lymphoma.
  • After aggressive radio- and chemotherapy, she presented to the neurosurgery service with a right Horner's syndrome, right C6 radiculopathy, and weakness of her right triceps and wrist extensors.
  • Both patients obtained magnetic resonance imaging revealing intradural extramedullary cervical nerve root associated mass lesions.
  • Two years after radiation therapy for his Hodgkin's lymphoma, the first patient underwent a C6 laminectomy at an outside institution for resection of a benign neurofibroma.
  • The second patient underwent a C5-6 hemilaminectomy and partial resection of a tumor also pathologically consistent with MPNST.
  • We present 2 case reports of patients who developed neurofibrosarcomatous tumors with malignant transformation after undergoing radiation therapy for Hodgkin's lymphoma.
  • Despite prompt surgical resection, these tumors exhibited aggressive behavior.
  • Numerous cases of soft tissue tumors have been described to arise in areas of prior radiation therapy; however, there have been rare reports of de novo MPNST after radiation therapy, especially in the setting of Hodgkin's lymphoma.
  • [MeSH-major] Hodgkin Disease / radiotherapy. Lymphatic Irradiation / adverse effects. Neoplasms, Radiation-Induced / pathology. Nerve Sheath Neoplasms / etiology. Spinal Neoplasms / etiology






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