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1. Cennamo A, Falsetto A, Tolomeo R, Cioffi E, Gallo G, De Pascale V: The first-reported case of diffuse purulent peritonitis in a patient with retroperitoneal Hodgkin disease (etiopathogenetic hypotheses). Ann Ital Chir; 2001 Nov-Dec;72(6):697-701
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  • We report a case of purulent diffuse peritonitis in a patient who was affected by Hodgkin lymphoma, with no evidence of other abdominal diseases.
  • This is a 54 y. old. white male who was admitted to our department with a history of asthenia, recurrent fever, dysphagia and abdominal pain.
  • In the plain abdominal radiology pneumoperitoneum was evident.
  • Duodenal perforation suspicion was confirmed by anamnesis and plain radiology which showed the presence of intra abdominal air.
  • A postoperative abdominal CT scan and histology of a biopsy taken during the second surgical operation showed a retroperitoneal Hodgkin lymphoma, which went to remission after chemotherapy.
  • Considering the two simultaneous clinical manifestations (retroperitoneal Hodgkin lymphoma and peritonitis), we made two pathogenetic hypotheses: a) The retroperitoneal disease produced lymphatic stagnation and peritoneal transudation, which then was infected;.
  • b) The abnormal lymph nodes were infected and the abdominal cavity was contaminated from retroperitoneum from blood/lymphatic stream or by contiguity.

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  • (PMID = 12061221.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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2. Bakrac M, Bonaci B, Krstic M, Simic S, Colovic M: A rare case of enteropathy-associated T-cell lymphoma presenting as acute renal failure. World J Gastroenterol; 2006 Apr 14;12(14):2301-4
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  • [Title] A rare case of enteropathy-associated T-cell lymphoma presenting as acute renal failure.
  • Enteropathy-associated T-cell lymphoma (EATCL) is a high grade, pleomorphic peripheral T-cell lymphoma usually with cytotoxic phenotypes.
  • Diagnosis of tubulointerstitial nephritis and polyserositis was confirmed with consecutive pulse doses of steroid therapy.
  • Magnetic resonance imaging showed thickened intestine wall, extremely augmented kidneys, enlarged intra-abdominal lymph nodes with extra-luminal compression of common bile duct.
  • Laparotomy with mesenterial adipous tissue and lymph glands biopsy was done.
  • Consecutive pathophysiological and immunohistochemical analyses confirmed the diagnosis of EATCL: CD45RO+, CD43+, CD3+.
  • The revision of renal pathophysiology substantiated the diagnosis.
  • The patient received chemotherapy, but unfortunately she died manifesting signs of pulmonary embolism caused by tumor cells.
  • [MeSH-major] Acute Kidney Injury / etiology. Celiac Disease / complications. Intestinal Neoplasms / complications. Lymphoma, T-Cell, Peripheral / complications

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  • (PMID = 16610043.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087668
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3. Aguayo P, Ho B, Fraser JD, Gamis A, St Peter SD, Snyder CL: Bowel obstruction after treatment of intra-abdominal tumors. Eur J Pediatr Surg; 2010 Jul;20(4):234-6
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  • [Title] Bowel obstruction after treatment of intra-abdominal tumors.
  • BACKGROUND: Tumors of the solid viscera are one of the most common types of pediatric malignancies.
  • Due to the intra-abdominal location of many of these neoplasms, laparotomy and/or bowel resection are often necessary, predisposing patients to postoperative intestinal obstruction.
  • Additionally, chemotherapy and radiation therapy may lead to acute and chronic bowel injury, also potentially predisposing these patients to postoperative bowel obstruction.
  • METHODS: A retrospective data analysis of all patients diagnosed with intra-abdominal Wilms' tumor, rhabdomyosarcoma, neuroblastoma, and Hodgkin's and non-Hodgkin's lymphoma in a single institution from 1997 to 2007 was conducted.
  • Data collected included demographic factors, operations, incidence of small bowel obstruction (SBO) and the use of adjuvant or neoadjuvant chemoradiation therapy.
  • Patients who developed SBO were compared to those who did not develop obstruction.
  • Data comparisons were analyzed statistically using Fisher's exact test, 2-tailed Student's t-Test, or chi-square proportional analysis with significance reported for p<0.05.
  • Mean age at diagnosis was 8.1+/-5.8 years.
  • Tumor distribution was as follows: Wilms' tumor: 56 (19%); non-Hodgkin's lymphoma: 71 (24%); Hodgkin's lymphoma: 64 (22%); rhabdomyosarcoma: 32 (11%); and neuroblastoma: 68 (24%).
  • CONCLUSION: Bowel obstruction is relatively uncommon after intra-abdominal malignancies in children.
  • Wilms' tumor, rhabdomyosarcoma and Burkitt's lymphoma appear to be associated with the highest risk of bowel obstruction.
  • [MeSH-major] Abdominal Neoplasms / surgery. Intestinal Obstruction / etiology. Laparotomy / adverse effects

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  • (PMID = 20496318.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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4. Macák J, Mukensnábl P, Kawano N, Bobot L, Dusková M, Vácha P: [Intra-abdominal desmoplastic small-cell tumor of the peritoneum]. Cesk Patol; 2003 Apr;39(2):69-75
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  • [Title] [Intra-abdominal desmoplastic small-cell tumor of the peritoneum].
  • Intensive chemotherapy was applied but two patients died of generalisation.
  • The 22-year-old woman is alive but with clinical evidence of generalisation in the abdominal cavity.
  • The "classical" type of IDSRT was found in all the cases.
  • In one case the tumour consisted of round and oval cells resembling a lymphoma.
  • Many different tumour types, such as lymphoma, Ewing sarcoma/PNET, neuroblastoma, alveolar rhabdomyosarcoma, malignant mesothelioma must be excluded.

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  • (PMID = 12874904.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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5. Shimamoto T, Hayashi S, Ando K, Yguchi M, Miyazawa K, Kimura Y, Mukai K, Serizawa H, Ohyashiki K: Anaplastic large-cell lymphoma which showed severe inflammatory status and myelodysplasia with increased VEGF and IL-6 serum levels after long-term immunosuppressive therapy. Am J Hematol; 2001 Jan;66(1):49-52
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  • [Title] Anaplastic large-cell lymphoma which showed severe inflammatory status and myelodysplasia with increased VEGF and IL-6 serum levels after long-term immunosuppressive therapy.
  • We report a patient with anaplastic large-cell lymphoma (ALCL) who has been given immunosuppressive therapy for Evans syndrome for 10 years.
  • He was admitted with spike fever, intra-abdominal lymphadenopathy, and multiple liver masses.
  • Examination of biopsy specimens obtained by para-aortic lymph nodes and liver masses resulted in a diagnosis of ALCL.
  • He was treated with combination chemotherapy (ABVD regimen), achieving complete remission.
  • Myelodysplasia and serum IL-6 and VEGF also normalized after treatment.
  • We assumed that ALCL resulted from long-term immunosuppressive therapy and that the up-regulation of IL-6 and VEGF played a role in pathogenesis of this type of lymphoma.
  • [MeSH-major] Autoimmune Diseases / drug therapy. Cyclosporine / adverse effects. Endothelial Growth Factors / blood. Immunosuppressive Agents / adverse effects. Interleukin-6 / blood. Lymphokines / blood. Lymphoma, Large B-Cell, Diffuse / drug therapy. Myelodysplastic Syndromes / etiology. Pancytopenia / drug therapy. Prednisolone / adverse effects
  • [MeSH-minor] Abdominal Pain / etiology. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Bone Marrow / pathology. CD4-CD8 Ratio. Cell Lineage. Combined Modality Therapy. DNA, Neoplasm / analysis. DNA, Viral / analysis. Dacarbazine / administration & dosage. Doxorubicin / administration & dosage. Fever / etiology. Fibroblast Growth Factor 2 / blood. Gene Rearrangement, B-Lymphocyte. Humans. Immunocompromised Host. Inflammation. Lymph Nodes / pathology. Male. Middle Aged. Remission Induction. Splenectomy. Syndrome. Vascular Endothelial Growth Factor A. Vascular Endothelial Growth Factors. Vinblastine / administration & dosage

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  • (PMID = 11426493.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / DNA, Viral; 0 / Endothelial Growth Factors; 0 / Immunosuppressive Agents; 0 / Interleukin-6; 0 / Lymphokines; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factors; 103107-01-3 / Fibroblast Growth Factor 2; 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; 83HN0GTJ6D / Cyclosporine; 9PHQ9Y1OLM / Prednisolone; ABVD protocol
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6. Nakagawa Y, Miura K, Yamazaki T, Ishizuka H, Takei K, Sawada U, Kura Y, Hatta Y, Takeuchi J: A case of treatment-related myelodysplastic syndrome spontaneously resolved by drug discontinuance. Int J Hematol; 2010 Apr;91(3):530-3
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  • [Title] A case of treatment-related myelodysplastic syndrome spontaneously resolved by drug discontinuance.
  • Although great advancements have been witnessed in treatment results for hematopoietic tumors in recent years, development of secondary malignant tumors induced by anti-cancer drugs still remains a serious issue.
  • A 24-year-old woman was diagnosed with follicular lymphoma in January 1998: she had developed bulky intra-abdominal lymphadenopathy, with repeated relapse and remission by several chemotherapy treatments.
  • Remission was induced by rituximab, administered at the time of relapse in 2001, followed by administration of 50 mg/day of CY since December 2001 for the prevention of relapse.
  • Anemia and thrombocytopenia developed around January 2003.
  • [MeSH-major] Antineoplastic Agents, Alkylating / adverse effects. Cyclophosphamide / adverse effects. Lymphoma, Follicular / drug therapy. Myelodysplastic Syndromes / chemically induced

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  • (PMID = 20155339.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 4F4X42SYQ6 / Rituximab; 8N3DW7272P / Cyclophosphamide
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7. Turial S, Karabul N, Gutjahr P, Engel V, Bierschock S, Schier F: Ovarian tumours: late extramedullary recurrence of acute leukaemia. Eur J Pediatr Surg; 2009 Jun;19(3):184-6
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  • Local therapy such as irradiation or extensive surgical resection of the mass is ineffective and unnecessary.
  • Treatment was initiated according to the CoALL 82-protocol.
  • At the age of 11, the girl presented with a huge abdominal mass.
  • Chemotherapy and low-dose radiotherapy succeeded in shrinking the tumour mass, making it operable.
  • Subsequently, she developed a painless abdominal tumour.
  • Laparoscopic lymph node staging was performed and biopsies were taken.
  • Chemotherapy was initiated according to the BFM protocol for ALL recurrence.
  • CONCLUSION: Because we experienced favourable results with laparoscopic biopsy in our patients, we are of the opinion that laparoscopy-assisted biopsies are well suited for the management of intra-abdominal tumours in systemic malignant disease.
  • [MeSH-major] Bone Marrow Neoplasms / pathology. Neoplasm Recurrence, Local. Ovarian Neoplasms / secondary. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • [MeSH-minor] Adolescent. Child, Preschool. Female. Humans. Ovariectomy. Treatment Outcome

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  • (PMID = 19212934.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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8. Sakakura C, Hagiwara A, Ikoma H, Hamada T, Taniwaki M, Horiike M, Yamagishi H: Massive lymphatic fluid leakage during laparoscopic lymphnode biopsy for abdominal malignancy. Hepatogastroenterology; 2002 Nov-Dec;49(48):1517-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Massive lymphatic fluid leakage during laparoscopic lymphnode biopsy for abdominal malignancy.
  • This report concerns massive lymphatic fluid leakage during laparoscopic abdominal lymphnode biopsy for mesenteric tumor of non-Hodgkin's disease.
  • Laparoscopic lymphnode biopsy was performed on a 58-year-old man who presented with a huge abdominal mass.
  • The initial diagnosis was based on abdominal computed tomography, which revealed a large mass.
  • This was followed by laparoscopic abdominal lymphnode biopsy for a definitive diagnosis.
  • Histological examination indicated the mass to be a B-cell type non-Hodgkin's lymphoma.
  • Hospitalization was uneventful, and the patient was discharged 7 days postoperatively to the Department of Internal Medicine for chemotherapy.
  • This new endoscopic approach offers a useful alternative to the traditional transabdominal excision of intra-abdominal lymphnodes, although attention must be paid to possible complications including massive intraoperative lymphatic leakage.
  • [MeSH-major] Abdominal Neoplasms / pathology. Biopsy / adverse effects. Laparoscopy / adverse effects. Lymph / secretion. Lymph Nodes / pathology. Lymphoma, Non-Hodgkin / pathology

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  • (PMID = 12397722.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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9. Okur FV, Oguz A, Karadeniz C, Citak C, Poyraz A, Boyunaga O: Refractoriness to rituximab monotherapy in a child with relapsed/refractory Burkitt non-Hodgkin lymphoma. Pediatr Hematol Oncol; 2006 Jan-Feb;23(1):25-31
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  • [Title] Refractoriness to rituximab monotherapy in a child with relapsed/refractory Burkitt non-Hodgkin lymphoma.
  • The authors describe a 6-year-old boy diagnosed with mediastinal Burkitt lymphoma with tumor invasion into bone marrow and both kidneys.
  • After receiving chemotherapy according to NHL BFM-95 protocol for the high-risk disseminated lymphoma, the patient reached complete remission.
  • He relapsed in the mediastinum at 5 months from the diagnosis.
  • Autologous stem cell transplantation could not be performed because of unresponsiveness to cytoreductive chemotherapy.
  • Twenty-three days after the last chemotherapy course, he received rituximab at a dose of 375 mg/m2 by intravenous infusion weekly, for a total of 8 dose.
  • However, multiple intra-abdominal metastatic lesions were detected at the end of the therapy.
  • He died because of disease progression, 11 months after the diagnosis.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Burkitt Lymphoma / drug therapy
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow Neoplasms / secondary. Child. Drug Resistance, Neoplasm. Fatal Outcome. Humans. Kidney Neoplasms / secondary. Male. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / pathology. Neoplasm Invasiveness. Palliative Care. Recurrence. Remission Induction. Rituximab

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  • (PMID = 16326409.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab
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10. Chung KM, Chuang SS, Hwang WS, Lee PS, Li CY: High dose chemotherapy and allogenic peripheral blood stem cell transplantation for multiple myeloma evolving from intra-abdominal plasmacytoma. Zhonghua Yi Xue Za Zhi (Taipei); 2002 Nov;65(11):557-60
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  • [Title] High dose chemotherapy and allogenic peripheral blood stem cell transplantation for multiple myeloma evolving from intra-abdominal plasmacytoma.
  • We present an unusual case of intra-abdominal plasmacytoma in a young woman which was misdiagnosed and treated as T cell lymphoma initially.
  • High dose chemotherapy followed by allogeneic peripheral stem cell blood transplantation (allo-PBSCT) was given.
  • [MeSH-major] Abdominal Neoplasms / complications. Hematopoietic Stem Cell Transplantation. Multiple Myeloma / therapy. Plasmacytoma / complications
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Melphalan / administration & dosage. Prednisolone / administration & dosage. Transplantation, Homologous

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  • (PMID = 12583522.001).
  • [ISSN] 0578-1337
  • [Journal-full-title] Zhonghua yi xue za zhi = Chinese medical journal; Free China ed
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi (Taipei)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 9PHQ9Y1OLM / Prednisolone; Q41OR9510P / Melphalan
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11. Kochi M, Fujii M, Kanamori N, Kaiga T, Takahashi T, Kobayashi M, Takayama T: Complete remission by chemotherapy in stage IE-IIE primary gastric lymphoma. Hepatogastroenterology; 2007 Jun;54(76):1285-8
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  • [Title] Complete remission by chemotherapy in stage IE-IIE primary gastric lymphoma.
  • BACKGROUND/AIMS: There are many controversies regarding the treatment for primary gastric non-Hodgkin's lymphoma (PGL).
  • We hypothesized that preoperative chemotherapy and extensive surgery would improve patient survival in the treatment of early stage patients with PGL.
  • All patients received preoperative chemotherapy, i.e.
  • Upon the completion of chemotherapy, the extensive surgery including total gastrectomy, splenectomy, cholecystectomy, and paraaortic lymphadenectomy were performed.
  • The response rates of preoperative chemotherapy and overall survival were analyzed.
  • In all patients, microscopic examinations did not reveal residual lymphoma cells in the resected stomach or lymph nodes.
  • Chemotherapy-related preoperative complications such as perforation or intestinal bleeding did not occur in any of the cases.
  • Postoperative complications developed in 30% (3/10) of patients and consisted of 2 pancreatic fistulas, 3 intra-abdominal abscesses, and 1 anastomotic leak.
  • CONCLUSIONS: Primary chemotherapy alone without surgery may produce complete remission in Stage IE-IIE PGL.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Non-Hodgkin / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Aged. Bleomycin / therapeutic use. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Female. Humans. Leucovorin / therapeutic use. Male. Methotrexate / therapeutic use. Middle Aged. Neoplasm Staging. Prednisone / therapeutic use. Preoperative Care. Prospective Studies. Remission Induction. Survival Analysis. Treatment Outcome. Vincristine / therapeutic use

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  • (PMID = 17629090.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q573I9DVLP / Leucovorin; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate; CHOP protocol; MACOP-B protocol
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12. Sfaxi M, Bouzouita A, Bouasker I, Kourda N, Ben Slama MR, Ben Jilani Baltaji S, Chebil M: [Primary bilateral adrenal T-cell lymphoma. A case report rarer than B-cell lymphoma]. Ann Endocrinol (Paris); 2008 Jun;69(3):249-53
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  • [Title] [Primary bilateral adrenal T-cell lymphoma. A case report rarer than B-cell lymphoma].
  • [Transliterated title] Lymphome surrénalien primitif bilatéral de phénotype T. Un cas clinique beaucoup plus rare que le lymphome B.
  • Primary adrenal lymphoma is a rare condition.
  • Adrenal lymphoma is often bilateral and in most of the cases of B-cell type.
  • T-cell lymphoma is exceptional.
  • We report a case of a 70-year-old man who was admitted for acute adrenal insufficiency due to primary bilateral adrenal T-cell lymphoma.
  • He had corticotherapy and surgical exploration for intra-abdominal sepsis.
  • Clinical features and imaging are not specific. (18)F-FDG PET Scan is an excellent mean to detect malignant tumor of adrenal gland.
  • The standard treatment is chemotherapy.
  • [MeSH-major] Adrenal Gland Neoplasms / radionuclide imaging. Lymphoma, T-Cell / radionuclide imaging
  • [MeSH-minor] Aged. Fatal Outcome. Fluorodeoxyglucose F18. Humans. Immunohistochemistry. Incidence. Lymphoma, B-Cell / epidemiology. Male. Multiple Organ Failure. Positron-Emission Tomography. Radiopharmaceuticals

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  • (PMID = 18455145.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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13. Tanaka Y, Kurata M, Togami K, Fujita H, Watanabe N, Matsushita A, Maeda A, Nagai K, Sada A, Matsui T, Takahashi T: Chronic eosinophilic leukemia with the FIP1L1-PDGFRalpha fusion gene in a patient with a history of combination chemotherapy. Int J Hematol; 2006 Feb;83(2):152-5
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  • [Title] Chronic eosinophilic leukemia with the FIP1L1-PDGFRalpha fusion gene in a patient with a history of combination chemotherapy.
  • He had developed intra-abdominal non-Hodgkin's lymphoma and in 1992 had received 3 courses of combination chemotherapy with doxorubicin (Adriamycin), cyclophosphamide, vincristine, methotrexate, bleomycin, and prednisolone.
  • The patient was orally given prednisolone (10 mg/day) and cyclophosphamide (50 mg/day) as HES treatment without a subsequent improvement of the eosinophilia.
  • Treatment with imatinib mesylate (300 mg/day) promptly brought about complete remission.
  • Although a number of similar eosinophilic cases have been reported, our patient may be the first such patient with a history of chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Hypereosinophilic Syndrome / etiology. Oncogene Proteins, Fusion / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics. mRNA Cleavage and Polyadenylation Factors / genetics
  • [MeSH-minor] Adult. Benzamides. Chronic Disease. Humans. Imatinib Mesylate. Lymphoma, Non-Hodgkin / complications. Lymphoma, Non-Hodgkin / drug therapy. Male. Molecular Sequence Data. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Sequence Analysis, DNA

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  • (PMID = 16513534.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzamides; 0 / Oncogene Proteins, Fusion; 0 / Piperazines; 0 / Pyrimidines; 0 / mRNA Cleavage and Polyadenylation Factors; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / FIP1L1-PDGFRA fusion protein, human; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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14. Alkhunaizi AM, Daabil RA, Dawamneh MF: Acute kidney injury secondary to lymphomatous infiltration and the role of kidney biopsy. Saudi Med J; 2008 Dec;29(12):1808-10
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  • We report a 47-year-old male patient who developed acute kidney injury requiring hemodialysis, associated with massive enlargement of both kidneys.
  • A part from intra-abdominal lymphadenopathy, there was no other organ or lymph node involvement.
  • A kidney biopsy established the diagnosis of non-Hodgkin's lymphoma.
  • The patient received chemotherapy with good response.
  • This case demonstrates that the kidney could be the primary organ involved in non-Hodgkin's lymphoma.
  • In addition, we have shown that renal biopsy is adequate to make a diagnosis of lymphoma without the need to do more invasive testing.
  • [MeSH-major] Acute Kidney Injury / etiology. Acute Kidney Injury / pathology. Kidney / pathology. Lymphoma, Non-Hodgkin / complications. Lymphoma, Non-Hodgkin / pathology

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  • (PMID = 19082238.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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15. Kunisaki Y, Muta T, Yamano Y, Kobayashi Y: Detection of two cell populations corresponding to distinct maturation stages in API-2/MLT-positive mucosa-associated lymphoid tissue lymphoma cells proliferating in pleural effusion. Int J Hematol; 2003 Nov;78(4):357-61
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  • [Title] Detection of two cell populations corresponding to distinct maturation stages in API-2/MLT-positive mucosa-associated lymphoid tissue lymphoma cells proliferating in pleural effusion.
  • A 66-year-old man was admitted to our hospital because of an intra-abdominal tumor and pleural effusion (PE).
  • Computed tomography scans showed extensive thickening of the gastric wall and bilateral massive PE without lymph node or pulmonary involvement.
  • The diagnosis was gastric mucosa-associated lymphoid tissue (MALT) lymphoma infiltrating to the PE, PB, and BM.
  • The patient had a good response to fludarabine treatment, which was followed with rituximab therapy.
  • In general, gastric MALT lymphoma cells have a tendency to differentiate into plasma cells.
  • In this article, we show that the cell character of API-2/MLT-positive MALT lymphoma is preserved even when the cells are disseminated.
  • This is the first published case, to our knowledge, in which two differentiation stages of MALT lymphoma cells infiltrating into PE have been confirmed by flow cytometric analysis.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / pathology. Oncogene Proteins, Fusion / analysis. Pleural Effusion, Malignant / pathology
  • [MeSH-minor] Aged. Antigens, Differentiation, B-Lymphocyte / analysis. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. B-Lymphocytes / pathology. Cell Adhesion Molecules / analysis. Cell Differentiation. Cell Division. Humans. Immunophenotyping. Male. Neoplasm, Residual. Stomach Neoplasms / diagnosis. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology

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  • (PMID = 14686495.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / API2-MALT1 fusion protein, human; 0 / Antigens, Differentiation, B-Lymphocyte; 0 / Cell Adhesion Molecules; 0 / Oncogene Proteins, Fusion
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16. Culić S, Kuljis D, Armanda V, Jankovic S: Successful management of bleeding with recombinant factor VIIa (NovoSeven) in a patient with Burkitt lymphoma and thrombosis of the left femoral and left common iliac veins. Pediatr Blood Cancer; 2007 Sep;49(3):332-5
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  • [Title] Successful management of bleeding with recombinant factor VIIa (NovoSeven) in a patient with Burkitt lymphoma and thrombosis of the left femoral and left common iliac veins.
  • We present the case of an 18-year-old female with Burkitt lymphoma involving the intra-abdominal and inguinal lymph nodes.
  • Chemotherapy and anticoagulant treatment resulted in mild thrombocytopenia and a prolonged prothrombin time, respectively, which exacerbated postoperative bleeding following surgical removal of a deep inguinal necrosis.
  • The patient has since achieved complete remission and subsequent antithrombotic therapy has resolved the vascular occlusion.
  • [MeSH-major] Factor VIIa / therapeutic use. Femoral Vein. Iliac Vein. Postoperative Hemorrhage / drug therapy. Venous Thrombosis / surgery
  • [MeSH-minor] Adolescent. Anticoagulants / adverse effects. Antineoplastic Agents / adverse effects. Burkitt Lymphoma / complications. Burkitt Lymphoma / drug therapy. Female. Heparin, Low-Molecular-Weight / adverse effects. Humans. Recombinant Proteins / therapeutic use. Thrombocytopenia / chemically induced. Thrombocytopenia / complications

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  • [Copyright] Copyright (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16514611.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Antineoplastic Agents; 0 / Heparin, Low-Molecular-Weight; 0 / Recombinant Proteins; EC 3.4.21.21 / Factor VIIa
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17. Crysandt M, Neumann B, Das M, Engelbertz V, Bendel M, Galm O, Osieka R, Jost E: Intraperitoneal application of rituximab in refractory mantle cell lymphoma with massive ascites resulting in local and systemic response. Eur J Haematol; 2007 Dec;79(6):546-9
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  • [Title] Intraperitoneal application of rituximab in refractory mantle cell lymphoma with massive ascites resulting in local and systemic response.
  • In the past decade, rituximab in combination with polychemotherapy has become the standard approach in most patients with advanced CD20-positive B-cell lymphoma.
  • In mantle cell lymphoma (MCL), follicular lymphoma and diffuse large B-cell lymphoma, rituximab has been used as monotherapy and in combination with various chemotherapy regimens in different treatment situations.
  • Here, we report a 64-yr-old woman who was previously treated with three different chemotherapy regimens for stage IV MCL.
  • The patient's general status declined and she developed massive ascites as the dominant clinical problem.
  • Local, intraperitoneal administration of rituximab was initiated as an experimental treatment approach.
  • After 11 doses of rituximab, the general status of the patient improved significantly, ascites resolved completely and computed tomography (CT) scans demonstrated a partial remission of intra-abdominal lymph nodes and splenomegaly.
  • Furthermore, we observed a regression of mediastinal lymph nodes, pleural effusion and centrocytes in peripheral blood as well as improvement of anaemia.
  • The response to the experimental treatment has maintained for more than 6 months.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Ascites / drug therapy. Infusions, Parenteral / methods. Lymphoma, Mantle-Cell / drug therapy
  • [MeSH-minor] Anemia / drug therapy. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Agents / administration & dosage. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Middle Aged. Rituximab. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • (PMID = 17903214.001).
  • [ISSN] 1600-0609
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
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18. Lasota J, Nordling S, Miettinen M: Testicular diffuse large cell lymphoma with tubule preservation--molecular genetic evidence of transformation from previous follicular lymphoma. Virchows Arch; 2000 Mar;436(3):276-83
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  • [Title] Testicular diffuse large cell lymphoma with tubule preservation--molecular genetic evidence of transformation from previous follicular lymphoma.
  • They may be primary manifestation of lymphoma or represent a relapse of a previous non-Hodgkin's lymphoma.
  • This report details a testicular large cell lymphoma, which was proven to be large cell transformation of a low-grade follicular lymphoma biopsied 8 years earlier.
  • Initially, a 38-year old man was diagnosed with cervical lymphadenopathy, and biopsy was interpreted as reactive follicular hyperplasia; no treatment was given, and the lymphadenopathy resolved spontaneously.
  • The patient died 7 months later with evidence for intra-abdominal and central nervous system lymphoma after a brief but temporary response to M-BACOD chemotherapy.
  • Orchiectomy specimen and gastroscopic biopsy showed diffuse large B-cell lymphoma (CD20+), which infiltrated between well-preserved tubules in the testis.
  • Histological comparison with 20 testicular lymphomas without previous lymphoma showed tubule infiltration in all cases, suggesting that the tubule-preserving infiltration pattern could be a histological marker for secondary lymphoma involvement in testis.
  • On re-examination, the lymph node 8 years prior was verified as follicular, predominantly small, cleaved cell lymphoma with bcl2-positive follicles.
  • The earlier follicular lymphoma and the subsequent diffuse large cell lymphoma were analyzed using polymerase chain reaction and showed identical sequences of the t(14;18) translocation and immunoglobulin heavy chain gene rearrangement.
  • Analysis of the VH-gene sequences from the follicular lymphoma revealed sequence heterogeneity consistent with ongoing mutation.
  • However, the transformed diffuse large cell lymphoma had no intraclonal variation, with the sequence matching with one of the subclones from the low-grade follicular lymphoma.
  • These results confirm that the large cell transformation of follicular lymphoma occurs in a single follicular lymphoma cell.
  • This case also indicates that the selection of the transformed clone can be part of the natural history of disease and can occur without exposure to chemotherapy.
  • [MeSH-major] Cell Transformation, Neoplastic. Genes, Immunoglobulin. Lymphoma, Follicular / genetics. Lymphoma, Follicular / pathology. Lymphoma, Large B-Cell, Diffuse / genetics. Lymphoma, Large B-Cell, Diffuse / pathology. Testicular Neoplasms / genetics. Testicular Neoplasms / pathology

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  • (PMID = 10782887.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY
  • [Chemical-registry-number] 0 / Immunoglobulin Heavy Chains
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19. Ting JY, Chan SY, Lung DC, Ho AC, Chiang AK, Ha SY, Tsoi NN, Chan GC: Intra-abdominal Rhizopus microsporus infection successfully treated by combined aggressive surgical, antifungal, and iron chelating therapy. J Pediatr Hematol Oncol; 2010 Aug;32(6):e238-40
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  • [Title] Intra-abdominal Rhizopus microsporus infection successfully treated by combined aggressive surgical, antifungal, and iron chelating therapy.
  • We report 2 cases of unusual intra-abdominal Rhizopus microsporus infection in children with acute leukemia as a result of an unprecedented outbreak due to oral intake of contaminated allopurinol tablets and ready-to-eat food items.
  • Among the 2 patients, one of them survived after aggressive combined surgical, antifungal (AmBisome, Caspofungin, and Posaconazole) and iron chelation therapy.
  • [MeSH-major] Abdomen / microbiology. Antifungal Agents / therapeutic use. Immunocompromised Host. Iron Chelating Agents / therapeutic use. Mucormycosis / immunology. Mucormycosis / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy. Humans. Leukemia, Myeloid, Acute / drug therapy. Leukemia, Myeloid, Acute / physiopathology. Male. Neutropenia / chemically induced. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / physiopathology. Rhizopus

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  • (PMID = 20661158.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Iron Chelating Agents
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20. Lefor AT: Laparoscopic interventions in lymphoma management. Semin Laparosc Surg; 2000 Jun;7(2):129-39
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic interventions in lymphoma management.
  • The role of the surgeon in the care of the patient with lymphoma is limited mostly to obtaining a diagnosis.
  • Laparoscopy can play a significant role in the care of the patient requiring accurate intra-abdominal staging.
  • The staging procedure is conducted in a fashion identical to the open procedure, including multiple liver biopsies, a splenectomy, and multiple lymph node biopsies.
  • Patients with non-Hodgkin's lymphoma almost never require staging, and laparoscopy may play a role in obtaining tissue for diagnosis in a small fraction of patients.
  • Patients with Hodgkin's disease who have diffuse disease (stages III and IV) never need staging because they will all receive chemotherapy.
  • Likewise, patients with limited disease (stage I) are usually treated with radiation therapy alone.
  • The laparoscopic approach to this procedure may afford benefits to the patient including decreased hospitalization, morbidity, and reduced delays in obtaining definitive treatment.
  • [MeSH-major] Hodgkin Disease / pathology. Laparoscopy. Lymphoma, Non-Hodgkin / pathology

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  • [Copyright] Copyright 2000 by W.B. Saunders Company
  • (PMID = 11320483.001).
  • [ISSN] 1071-5517
  • [Journal-full-title] Seminars in laparoscopic surgery
  • [ISO-abbreviation] Semin Laparosc Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 55
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21. Ariad S, Benharroch D, Lupu L, Davidovici B, Dupin N, Boshoff C: Early peripheral lymph node involvement of human herpesvirus 8-associated, body cavity-based lymphoma in a human immunodeficiency virus-negative patient. Arch Pathol Lab Med; 2000 May;124(5):753-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early peripheral lymph node involvement of human herpesvirus 8-associated, body cavity-based lymphoma in a human immunodeficiency virus-negative patient.
  • Human herpesvirus 8 is also found in an unusual clinicopathologic form of body cavity-based B-cell lymphoma, which has been named primary effusion lymphoma (PEL) and occurs primarily in HIV-positive patients.
  • We describe a case of an HHV-8-associated lymphoma, with ascites, pleural effusion, and axillary lymphadenopathy in an HIV-negative patient.
  • The pleural fluid contained large atypical lymphoid cells and was suggestive of lymphoma but could not provide a conclusive diagnosis of PEL.
  • The lymph node contained groups of large anaplastic lymphoid cells.
  • Polymerase chain reaction for HHV-8 performed on the lymph node specimen was positive, establishing the diagnosis of PEL.
  • The patient did not respond to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine sulfate, and prednisone and progressively developed, massive intra-abdominal solid tumor formation.
  • To our knowledge, this is the first report of a case of PEL that demonstrates peripheral lymph node involvement at diagnosis and the first report of PEL in an Israeli patient.
  • [MeSH-major] HIV Seronegativity. Herpesvirus 8, Human / isolation & purification. Lymph Nodes / pathology. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / virology
  • [MeSH-minor] Aged. Antigens, CD30 / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Axilla. Biopsy. Fatal Outcome. Humans. Male. Mucin-1 / analysis. Pleural Effusion, Malignant / etiology. Pleural Effusion, Malignant / radiography. Polymerase Chain Reaction

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  • (PMID = 10782162.001).
  • [ISSN] 0003-9985
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Mucin-1
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22. Ugur H, Tacyildiz N, Yavuz G, Unal E, Sayili A, Emir S, Kansu A, Kuloglu Z, Bahar K: Obstructive jaundice: an unusual initial manifestation of intra-abdominal non-Hodgkin lymphoma in a child. Pediatr Hematol Oncol; 2006 Jan-Feb;23(1):87-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Obstructive jaundice: an unusual initial manifestation of intra-abdominal non-Hodgkin lymphoma in a child.
  • Although surgical drainage is one of the initial treatment choices in some cases, usually lymphomatous masses rapidly response to chemotherapy and jaundice decreases due to regression of the mass, without any surgical procedure.
  • Histological examination of the specimen, which was taken from the mass by endoscopic biopsy, revealed Burkitt lymphoma infiltrating the duodenum.
  • Chemotherapy including cyclophosphamide was started immediately.
  • In conclusion, biliary tract obstruction due to non-Hodgkin lymphoma can be effectively treated with chemotherapy alone without any surgical procedure.
  • [MeSH-major] Abdominal Neoplasms / pathology. Jaundice, Obstructive / etiology. Lymphoma, Non-Hodgkin / pathology
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Burkitt Lymphoma / pathology. Cyclophosphamide / therapeutic use. Duodenal Neoplasms / pathology. Female. Humans. Treatment Outcome

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  • (PMID = 16326418.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 8N3DW7272P / Cyclophosphamide
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23. Brihi E, Akoum R, Saade M, Chahine G: Abdominal irradiation after chemotherapy in non-Hodgkin's lymphoma: review of 32 patients. Mol Immunol; 2003 Jul;39(17-18):1121-8
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  • [Title] Abdominal irradiation after chemotherapy in non-Hodgkin's lymphoma: review of 32 patients.
  • OBJECTIVE: Our objective is to evaluate the efficacy and toxicity of abdominal irradiation after chemotherapy in the management of Non-Hodgkin's Lymphoma.
  • METHODS: Between 1982 and 1997, 32 patients underwent abdominal irradiation; as adjuvant treatment to chemotherapy (5 patients), as curative treatment for residual mass (9 patients) or as salvage treatment for refractory disease (18 patients).
  • The dose administered to the total abdomen was 18-20 Gy at the rate of 1.5-1.8 Gy per daily fraction followed by a boost to gross disease up to a total dose of 40-44 Gy.
  • The local control was significantly better in patients with follicular type lymphoma than in those with the diffuse type.
  • CONCLUSION: Adjuvant whole abdominal irradiation is feasible and efficient in patients with Non-Hodgkin's Lymphoma at high risk of intra-abdominal failure.
  • Abdominal irradiation for residual disease consolidates remission with acceptable toxicity.
  • Salvage radiotherapy for abdominal failure after chemotherapy provides significant palliation and prolongation of survival.
  • [MeSH-major] Lymphoma, Non-Hodgkin / drug therapy. Lymphoma, Non-Hodgkin / radiotherapy
  • [MeSH-minor] Abdomen. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Humans. Male. Middle Aged. Prednisone / administration & dosage. Radiotherapy, Adjuvant / adverse effects. Recurrence. Safety. Survival Rate. Treatment Failure. Vincristine / administration & dosage

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  • (PMID = 12835089.001).
  • [ISSN] 0161-5890
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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