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1. Miettinen M, Kraszewska E, Sobin LH, Lasota J: A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia. Cancer; 2008 Feb 1;112(3):645-9
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia.
  • BACKGROUND: Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract that are driven by activated KIT-signalling or platelet-derived growth factor receptor-alpha (PDFGRA) signaling.
  • These tumors most commonly occur in the stomach and small intestine and encompass a clinical spectrum from benign to malignant.
  • BACKGROUND: Nine patients (2 with gastric GISTs and 7 with GISTs of the small intestine) developed myeloid leukemia.
  • RESULTS: The leukemias developed 1.7 to 21 years after the GIST (median interval, 6 years).
  • None of the GIST patients had received radiotherapy or chemotherapy prior to the leukemia diagnosis.
  • All but 1 GIST case was found to have a low mitotic rate (0-1 per 50 high-power fields); however, tumor size varied from 3 to 18 cm (median, 4.5 cm).
  • [MeSH-major] Gastrointestinal Stromal Tumors / epidemiology. Intestinal Neoplasms / epidemiology. Leukemia, Myeloid / epidemiology. Stomach Neoplasms / epidemiology


2. McLoughlin MT, Byrne MF: Endoscopic stenting: where are we now and where can we go? World J Gastroenterol; 2008 Jun 28;14(24):3798-803

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Self expanding metal stents (SEMS) play an important role in the management of malignant obstructing lesions in the gastrointestinal tract.
  • The development of the polyflex stent, which is a removable self expanding plastic stent, allows temporary stent insertion for benign esophageal disease and possibly for patients undergoing neoadjuvant chemotherapy prior to esophagectomy.
  • Potential complications of SEMS insertion include perforation, tumour overgrowth or ingrowth, and stent migration.
  • Newer stents are being developed with the aim of increasing technical and clinical success rates, while reducing complication rates.
  • Other areas of development include biodegradable stents for benign disease and radioactive or drug-eluting stents for malignant disease.
  • [MeSH-minor] Colonic Neoplasms / surgery. Esophageal Neoplasms / surgery. Gastrointestinal Neoplasms / surgery. Humans. Intestinal Obstruction / surgery

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  • (PMID = 18609702.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2721435
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3. Korsisaari N, Kasman IM, Forrest WF, Pal N, Bai W, Fuh G, Peale FV, Smits R, Ferrara N: Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice. Proc Natl Acad Sci U S A; 2007 Jun 19;104(25):10625-30
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  • Anti-VEGF-A monoclonal antibodies, in combination with chemotherapy, result in a survival benefit in patients with metastatic colorectal and non-small cell lung cancer, but little is known regarding the impact of anti-VEGF-A therapy on benign or premalignant tumors.
  • The Apc+/min mice have been widely used as a model recapitulating early intestinal adenoma formation.
  • To investigate whether tumor growth in Apc+/min mice is mediated by VEGF-A-dependent angiogenesis, we used two independent approaches to inhibit VEGF-A: monotherapy with a monoclonal antibody (Mab) targeting VEGF-A and genetic deletion of VEGF-A selectively in intestinal epithelial cells.
  • Short-term (3 or 6 weeks) treatment with anti-VEGF-A Mab G6-31 resulted in a nearly complete suppression of adenoma growth throughout the small intestine.
  • Long-term (up to 52 weeks) treatment with Mab G6-31 led to a substantial increase in median survival.
  • Deletion of VEGF-A in intestinal epithelial cells of Apc+/min mice yielded a significant inhibition of tumor growth, albeit of lesser magnitude than that resulting from Mab G6-31 administration.
  • These results establish that inhibition of VEGF-A signaling is sufficient for tumor growth cessation and confers a long-term survival benefit in an intestinal adenoma model.
  • Therefore, VEGF-A inhibition may be a previously uncharacterized strategy for the prevention of the angiogenic switch and growth in intestinal adenomas.
  • [MeSH-minor] Adenoma / blood supply. Adenoma / genetics. Adenoma / immunology. Adenoma / therapy. Animals. Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / pharmacology. Gene Deletion. In Situ Hybridization. Intestinal Neoplasms / blood supply. Intestinal Neoplasms / genetics. Intestinal Neoplasms / immunology. Intestinal Neoplasms / therapy. Mice. Mice, Inbred C57BL. Signal Transduction / immunology. Survival Analysis. Time Factors

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  • (PMID = 17553957.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Vascular Endothelial Growth Factor A
  • [Other-IDs] NLM/ PMC1888576
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4. Huscher A, Bignardi M, Magri E, Vitali E, Pasinetti N, Costa L, Frata P, Magrini SM: Determinants of small bowel toxicity in postoperative pelvic irradiation for gynaecological malignancies. Anticancer Res; 2009 Nov;29(11):4821-6
MedlinePlus Health Information. consumer health - Intestinal Obstruction.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Determinants of small bowel toxicity in postoperative pelvic irradiation for gynaecological malignancies.
  • BACKGROUND: Patients treated with postoperative radiotherapy for endometrial and cervical carcinomas from 1981 to 2000 were retrospectively analysed in order to assess the rate of late small bowel toxicity.
  • PATIENTS AND METHODS: Eight hundred and six patients had received pelvic irradiation, with total doses of 40-55 Gy.
  • Three hundred and eighteen patients had been treated for cervical and 488 for endometrial cancer; 46 had diabetes and 22 vascular diseases; 141 had a history of smoking and 367 were previously submitted to surgery for benign diseases.
  • A CT treatment plan had been applied in 285 patients; 256 had been treated by arc moving therapy, 232 with 2 opposed beams (AP-PA) and 318 with 3 or 4 coplanar beams.
  • Thirty-four women had received chemotherapy.
  • Eighty-one had needed treatment discontinuation due to acute small bowel toxicity.
  • Thirty five patients had bowel obstructions, after a median time of 31 months.
  • [MeSH-major] Endometrial Neoplasms / radiotherapy. Intestinal Fistula / etiology. Intestinal Obstruction / etiology. Intestine, Small / radiation effects. Radiation Injuries / etiology. Uterine Cervical Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Middle Aged. Radiotherapy / adverse effects. Retrospective Studies

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  • (PMID = 20032441.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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5. Hardingham JE, Hewett PJ, Sage RE, Finch JL, Nuttall JD, Kotasek D, Dobrovic A: Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease. Int J Cancer; 2000 Jan 20;89(1):8-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease.
  • Detection of carcinoma cells in the peripheral circulation at presentation may identify a subgroup of patients with micro-metastatic disease who may benefit from adjuvant chemotherapy or radiotherapy.
  • Our aim was to determine the presence and clinical significance of colon carcinoma cells in peripheral blood at the time of surgery.
  • Preoperative peripheral blood samples were collected from 94 patients with CRC and 64 patients undergoing bowel resection for benign conditions (adenoma, diverticular disease or Crohn's colitis).
  • Kaplan-Meier survival analysis showed that detection of epithelial cells in preoperative blood was associated with reduced disease-free and overall survival (log-rank test, p = 0.0001).
  • Surprisingly, circulating epithelial cells were detected in 3/30 (10%) patients resected for adenoma, and in 4/34 (12%) patients resected for benign inflammatory conditions, suggesting that cells from nonmalignant colonic epithelium may also gain entry into the bloodstream in the presence of bowel pathology.
  • [MeSH-major] Colorectal Neoplasms / blood. Epithelial Cells. Intestinal Diseases / blood. Intestinal Mucosa / cytology. Neoplastic Cells, Circulating
  • [MeSH-minor] Adenoma / blood. Adult. Aged. Aged, 80 and over. Biomarkers / analysis. Humans. Immunomagnetic Separation. Inflammatory Bowel Diseases / blood. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction. Survival Analysis. Tumor Cells, Cultured


6. Anyanwu SN, Nwofor AM: Primary jejuno-ileal neoplasms in eastern Nigeria. Niger Postgrad Med J; 2003 Mar;10(1):23-5
MedlinePlus Health Information. consumer health - Intestinal Cancer.

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  • [Title] Primary jejuno-ileal neoplasms in eastern Nigeria.
  • Small intestinal neoplasms are uncommon with reported incidences of less than 1% of GI neoplasms.
  • A retrospective review of cases of small intestinal neoplasms seen by the authors in a ten-year period is presented.
  • Six patients presented with intestinal obstruction, 3 with features of chronic ill-health while 1 was an incidental finding.
  • One patient had a benign lesion (Peutz-Jeghers Syndrome).
  • Treatment offered included resection of small gut in 7 patients and ileo-colectomy in 3 patients.
  • Three patients with lymphosarcoma had a full course of cytotoxic chemotherapy.
  • Neoplasms of the small gut presents late in our environment.
  • [MeSH-major] Ileal Neoplasms. Jejunal Neoplasms
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Infant. Intestinal Neoplasms / etiology. Male. Middle Aged. Nigeria

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  • (PMID = 12717460.001).
  • [ISSN] 1117-1936
  • [Journal-full-title] The Nigerian postgraduate medical journal
  • [ISO-abbreviation] Niger Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Nigeria
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7. Knudsen AL, Bülow S: [Desmoid tumor in familial adenomatous polyposis]. Ugeskr Laeger; 2000 Oct 16;162(42):5628-31
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  • [Title] [Desmoid tumor in familial adenomatous polyposis].
  • [Transliterated title] Desmoid tumor ved familiaer adenomatøs polypose.
  • INTRODUCTION: Desmoid tumors (DT) are rare benign tumors that do not metastasize, but tend to invade locally.
  • DT are frequently seen in patients with familial adenomatous polyposis (FAP), and diagnosis and treatment are often difficult.
  • METHOD: The article presents the clinical picture, diagnosis and treatment of DT in patients registered in the Danish Polyposis Register by the end of 1999.
  • RESULTS: Twenty-seven of 486 patients (6%) had DT.
  • Eighteen patients were alive at the time of evaluation.
  • DT were found in the mesentery in 42%, in the abdominal wall in 40%, in the retroperitoneum in 8% and only 10% on the extremities.
  • Fifty percent of the patients had complications (intestinal obstruction, hydronephrosis or fistulas), and 2/9 deaths were caused by DT.
  • Ninety-three percent were treated with surgery, NSAIDs, antioestogenic drugs, chemotherapy or radiotherapy, but all modalities proved disappointing, except for treatment with a combination of the NSAID sulindac and tamoxifen.
  • DISCUSSION: Surgical excision is recommended in patients with DT in the abdominal wall.
  • First line treatment of mesenteric DT is Clinoril in combination with tamoxifen.
  • Elective surgery may be considered in patients with a small well-defined DT with no signs of invasion of vital structures, and in patients with imminent bowel ischaemia or obstruction.
  • The prognosis for mesenteric DT is grave, and improvement of the therapeutic strategy awaits current international studies.
  • [MeSH-major] Abdominal Neoplasms. Adenomatous Polyposis Coli. Fibromatosis, Aggressive. Peritoneal Neoplasms. Retroperitoneal Neoplasms
  • [MeSH-minor] Adult. Antineoplastic Agents / administration & dosage. Colectomy. Colonic Neoplasms / complications. Colonic Neoplasms / diagnosis. Colonic Neoplasms / surgery. Combined Modality Therapy. Female. Humans. Male. Prognosis. Registries

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  • (PMID = 11059301.001).
  • [ISSN] 0041-5782
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] DENMARK
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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8. Seow-Choen F: The management of desmoids in patients with familial adenomatous polyposis (FAP). Acta Chir Iugosl; 2008;55(3):83-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This risk is about 852 times the risk for the population at large.
  • Desmoids are benign neoplasms that are capable of infiltrating locally with a high risk of recurrence (25-65%) even after extirpating surgery.
  • Simple drug treatment with tamoxifen or NSAIDS like sulindac should be used as first line treatment as it carries a response in 30-50% of patients.
  • Surgery for intra-abdominal desmoids should really only be attempted for intestinal obstruction or ureteric obstruction.
  • Dacarbazine-Doxorubicin chemotherapy may have dramatic response in some cases.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Fibromatosis, Aggressive / therapy

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  • (PMID = 19069698.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Serbia
  • [Number-of-references] 21
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9. Chang WC, Sheu BC, Lin MC, Chow SN, Huang SC: Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report. Int J Gynecol Cancer; 2005 May-Jun;15(3):549-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian of borderline malignancy: a case report.
  • Epithelial ovarian tumors of borderline malignancy are tumors with histologic features and biologic behavior between benign and frankly malignant epithelial ovarian neoplasms.
  • Here, we present a 35-year-old patient with carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian tumor of borderline malignancy.
  • Total hysterectomy, bilateral salpingo-oophorectomy, appendectomy, and omentectomy were performed, and the frozen pathology during operation showed mucinous tumor of borderline malignancy of left ovary on April 18, 2002.
  • The patient was followed at our outpatient department for 19 months after operation and was free of the disease without any adjuvant chemotherapy.
  • It is difficult to determine whether intestinal-type borderline mucinous tumors with intraepithelial carcinoma are associated with a worse prognosis compared with those with epithelial atypia alone due to disparate results in the published literature.
  • However, too few cases of carcinosarcoma-like mural nodule in mucinous tumor have been published to warrant a conclusion regarding their prognosis.
  • [MeSH-major] Carcinosarcoma / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness. Prognosis

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  • (PMID = 15882184.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Paulino AC, Wen BC, Brown CK, Tannous R, Mayr NA, Zhen WK, Weidner GJ, Hussey DH: Late effects in children treated with radiation therapy for Wilms' tumor. Int J Radiat Oncol Biol Phys; 2000 Mar 15;46(5):1239-46
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  • [Title] Late effects in children treated with radiation therapy for Wilms' tumor.
  • PURPOSE: To determine the frequency and types of late effects in children receiving radiation therapy (RT) for Wilms' tumor.
  • MATERIALS AND METHODS: From 1968 to 1994, 55 children received megavoltage RT at our institution as part of treatment for Wilms' tumor.
  • All patients received chemotherapy; the most common agents were actinomycin-D/vincristine/adriamycin in 13 and actinomycin-D/vincristine in 18.
  • RESULTS: Of 42 patients, 13 (31.0%) did not have late effects of treatment.
  • The number of patients who developed muscular hypoplasia, limb length inequality, kyphosis, and iliac wing hypoplasia were seven (16.7%), five (11.9%), three (7.1%), and three (7.1%), respectively.
  • Median time to development of scoliosis was 102 months, with a range of 16-146 months.
  • Only one of 12 Group A patients developed scoliosis.
  • Of 23 patients, five irradiated within 10 days of surgery and one of 19 irradiated after 10 days developed bowel obstruction (p = 0.09, log rank test).
  • Three patients developed hypertension with normal blood urea nitrogen (BUN) and creatinine levels; another patient had chronic renal insufficiency in a nonirradiated kidney.
  • One patient developed diffuse interstitial pneumonitis.
  • Four patients developed benign neoplasms; three were in the RT field (two osteochondroma, one lipoma) and one outside (cervical intraepithelial neoplasia II).
  • CONCLUSIONS: Late effects of therapy were seen in more than two thirds of children treated for Wilms' tumor.
  • [MeSH-major] Kidney Neoplasms / radiotherapy. Radiation Injuries / complications. Wilms Tumor / radiotherapy
  • [MeSH-minor] Child. Child, Preschool. Dose-Response Relationship, Radiation. Female. Fertility / radiation effects. Follow-Up Studies. Humans. Infant. Intestinal Obstruction / etiology. Intestine, Small / radiation effects. Kidney Diseases / etiology. Kyphosis / etiology. Male. Muscles / radiation effects. Neoplasm Staging. Neoplasms, Second Primary / etiology. Puberty, Delayed / etiology. Scoliosis / etiology. Time Factors

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  • (PMID = 10725637.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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11. Atmatzidis KS, Pavlidis TE, Galanis IN, Papaziogas BT, Papaziogas TB: Malignant fibrous histiocytoma of the abdominal cavity: report of a case. Surg Today; 2003;33(10):794-6
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  • Malignant fibrous histiocytoma (MFH) is a soft-tissue sarcoma originating from fibroblast cells, characterized by a high rate of metastasis or recurrence.
  • This tumor rarely develops in the gastrointestinal tract, with no more than 30 cases described in the literature.
  • A computed tomography (CT) scan of the abdomen revealed multiple solid tumors in the peritoneal cavity.
  • We performed exploratory laparotomy and found at least 15 solid whitish tumors attached to the wall of the small intestine, as well as to the parietal peritoneum.
  • All of the tumors were excised, most of which were about 10 cm in diameter.
  • Histopathological findings indicated a stromal tumor consisting of spindle cells, and immunohistochemical examination of the resected specimens established the definite diagnosis of a pleomorphic MFH.
  • The patient had an uneventful postoperative course and was given adjuvant chemotherapy.
  • We review the clinical picture of this tumor in the abdominal cavity, and discuss its diagnosis, pathogenesis, and treatment.
  • [MeSH-major] Histiocytoma, Benign Fibrous / surgery. Intestinal Neoplasms / surgery. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Intestine, Small. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 14513333.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Wu L, Zhang W, Li H, Li L, Kong W, Liu L: [Clinical analysis of 74 cases with ovarian thecoma]. Zhonghua Fu Chan Ke Za Zhi; 2002 Feb;37(2):101-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To study the clinical pathologic characteristics, treatment and prognostic factors of ovarian thecoma.
  • METHODS: From 1958 approximately 1998, a total of 74 patients with benign and malignant thecoma were retrospectively analyzed.
  • RESULTS: The reviewed diagnosis were 8 patients with malignant thecoma, 66 patients were benign thecoma.
  • Nine of 66 patients with benign thecoma appeared cell proliferative activity.
  • Fifteen patients with benign thecoma were evaluated blood serum CA(125), the CA(125) were elevated in 9 of 15 patients.
  • In 2 of 9 patients with cell proliferative activity, the tumors invaded adjacent tissues or relapsed, after received operation and pelvic radiotherapy, they are alive 11 years and 27 years respectively.
  • Among 8 patients with malignant thecoma, 4 patients without postoperation therapy or with non-standard chemotherapy died in 2 years postoperation, the other 4 patients received operation, postoperational radiotherapy or (and) chemotherapy, 1 of 4 patients died of irradiation intestinal fistule 4 years later; two patients are alive without disease more than 10 years, another one for 2 years.
  • CONCLUSIONS: Theca cell tumor of ovary have good prognosis, but we should pay attention to thecomas with proliferative activity.
  • The prognosis of malignant thecomas is poor, postoperative systemic chemotherapy or radiotherapy to the patients with malignant thecomas can improve their survival.
  • [MeSH-major] Ovarian Neoplasms / pathology. Thecoma / pathology

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  • (PMID = 11953075.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Prager GW, Poettler M, Schmidinger M, Mazal PR, Susani M, Zielinski CC, Haitel A: CD98hc (SLC3A2), a novel marker in renal cell cancer. Eur J Clin Invest; 2009 Apr;39(4):304-10
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  • BACKGROUND: In a variety of malignant diseases, molecular targeting represents a therapeutic option, whereby, when compared with chemotherapy, fewer side effects are thought to be expected.
  • Especially in renal cell cancer (RCC), tyrosine kinase-inhibitors have been established as useful and highly effective therapy.
  • However, tyrosine kinase-inhibitors currently approved for RCC treatment lack single molecule specificity and bear a variety of side effects of the gastro-intestinal tract, skin, heart and haematopoietic system.
  • Therefore, the identification of novel cell surface markers is sought, which might lead to novel diagnostic and therapeutic strategies in cancer.
  • MATERIAL AND METHODS: Paraffin-embedded RCCs from a well characterized tissue bank were immunohistochemically quantified for embryonic transmembrane antigen CD98hc (SLC3A2) expression and semi-quantitative analyses were correlated with subtype or grade of differentiation.
  • RESULTS: We found increased CD98hc expression in different types of malign RCCs, among them clear cell (cc)RCC, papillary (p)RCC and chromophobe (ch)RCC, but lack of expression in the benign renal oncocytoma.
  • Furthermore, the more malignant type II pRCC significantly higher expressed CD98hc than the less malignant and more differentiated type I pRCC (type II 83.34%, type I 4.76% CD98hc positive, P < 0.00001; n = 51).
  • The established marker for type I pRCC, Cytokreatin 7, showed 95.24% expression in type I and 26.67% expression in type II pRCC (P < 0.00001, n = 51).
  • In pRCCs, CD98hc might represent a novel and reliable marker for type II pRCC.
  • [MeSH-major] Antigens, CD98 Heavy Chain / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 19292886.001).
  • [ISSN] 1365-2362
  • [Journal-full-title] European journal of clinical investigation
  • [ISO-abbreviation] Eur. J. Clin. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD98 Heavy Chain; 0 / Biomarkers, Tumor
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14. Merchant NB, Parikh AA, Kooby DA: Should all distal pancreatectomies be performed laparoscopically? Adv Surg; 2009;43:283-300
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  • [Title] Should all distal pancreatectomies be performed laparoscopically?
  • There are both enough experience and data (though retrospective) to confirm that LDP with or without spleen preservation appears to be a safe treatment for benign or noninvasive lesions of the pancreas.
  • Based on the fact that LDP can be performed with similar or shorter operative times, blood loss, complication rates, and length of hospital stay than ODP, it can be recommended as the treatment of choice for benign and noninvasive lesions in experienced hands when clinically indicated.
  • It is very difficult to make clear recommendations with regard to laparoscopic resection of malignant pancreatic tumors due to the lack of conclusive data.
  • Potential benefits of laparoscopic resection for cancer include the ability to inspect the abdomen and abort the procedure with minimal damage if occult metastases are identified.
  • This does not delay the onset of palliative chemotherapy, which would be the primary treatment in that circumstance.
  • In fact, there is evidence to suggest that there is a greater likelihood of receiving systemic therapy if a laparotomy is avoided in patients who have radiologically occult metastases.
  • Faster wound healing may also translate into a shorter waiting time before initiating adjuvant chemotherapy and/or radiation therapy.
  • Another aspect that draws some controversy is that of the totally laparoscopic procedure versus the hand-access approach.
  • The HALS approach allows for this, and the opportunity to control bleeding during the procedure.
  • Finally, it is important to remember that if the procedure is failing to progress laparoscopically, or if cancer surgery principles are likely to be violated, the surgeon (and the patient) must be willing to abort the laparoscopic approach and complete the operation using standard open technique.
  • Additional areas of discovery are in staple line reinforcement for left pancreatectomy and suturing technology for pancreatico-intestinal anastomosis.
  • Can we enucleate a small tumor off the pancreatic body by passing an endoscope through the gastric (or colonic) wall, and bring the specimen out via the mouth or anus?
  • Pioneers have already developed a porcine model of left pancreatectomy.

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  • (PMID = 19845186.001).
  • [ISSN] 0065-3411
  • [Journal-full-title] Advances in surgery
  • [ISO-abbreviation] Adv Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 95
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15. Wani I: Mesenteric lymphangioma in adult: a case series with a review of the literature. Dig Dis Sci; 2009 Dec;54(12):2758-62
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  • Mesenteric lymphangioma is a rare benign tumor with nonspecific clinical features.
  • Two patients presented with painless abdominal swelling who were being managed as a case of abdominal tuberculosis and a third one had features of intestinal obstruction.
  • Although rare and difficult to diagnose preoperatively, surgical resection is to be considered gold standard treatment for mesenteric lymphangioma.
  • [MeSH-major] Lymphangioma / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Antitubercular Agents / therapeutic use. Diagnostic Errors. Humans. Intestinal Obstruction / etiology. Male. Mesentery. Middle Aged. Tuberculosis, Gastrointestinal / diagnosis. Tuberculosis, Gastrointestinal / drug therapy. Tuberculosis, Lymph Node / diagnosis. Tuberculosis, Lymph Node / drug therapy. Unnecessary Procedures. Young Adult

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  • [Copyright] © Springer Science+Business Media, LLC 2009
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  • (PMID = 19142726.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents
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16. Masferrer J: Approach to angiogenesis inhibition based on cyclooxygenase-2. Cancer J; 2001 Nov-Dec;7 Suppl 3:S144-50
Hazardous Substances Data Bank. CELECOXIB .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • COX-2 is inducible and is present in inflammatory foci, tumors, and neovasculature.
  • Expression of COX-2 appears to be important in tumor promotion, growth, and metastasis.
  • COX inhibitors have a major role in the treatment of inflammation and pain.
  • Epidemiologic evidence in patients who take nonsteroidal anti-inflammatory drugs links COX inhibition with decreases in malignant esophageal, stomach, colon, lung, and breast tumors.
  • Nonselective COX inhibitors have demonstrated efficacy in control of familial adenomatous polyposis, a disorder associated with the development of thousands of benign intestinal polyps.
  • Angiogenesis is a feature of both benign and malignant disease.
  • Because COX-2 is up-regulated in the neovasculature of the rheumatoid pannus and in malignant tumors and their surrounding stroma, selective COX-2 inhibitors may be able to modify the progression of these disorders through the control of angiogenesis.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antineoplastic Agents / therapeutic use. Cyclooxygenase Inhibitors / therapeutic use. Sulfonamides / therapeutic use
  • [MeSH-minor] Animals. Celecoxib. Colonic Neoplasms / drug therapy. Colonic Neoplasms / enzymology. Cyclooxygenase 2. Cyclooxygenase 2 Inhibitors. Humans. Isoenzymes / biosynthesis. Isoenzymes / drug effects. Membrane Proteins. Neovascularization, Pathologic / prevention & control. Prostaglandin-Endoperoxide Synthases / biosynthesis. Prostaglandin-Endoperoxide Synthases / drug effects. Prostaglandins / metabolism. Pyrazoles

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  • (PMID = 11779086.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 0 / Cyclooxygenase 2 Inhibitors; 0 / Cyclooxygenase Inhibitors; 0 / Isoenzymes; 0 / Membrane Proteins; 0 / Prostaglandins; 0 / Pyrazoles; 0 / Sulfonamides; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; JCX84Q7J1L / Celecoxib
  • [Number-of-references] 38
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17. Eyssartier E, Harper L, Michel JL, Rivière JP, Vanderbecken S, De Napoli-Cocci S: Rapidly growing mature retroperitoneal teratomas. J Pediatr Hematol Oncol; 2009 Sep;31(9):705-6
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  • Retroperitoneal mature teratomas are rare benign tumors, most commonly found in neonates and young adults.
  • In both cases, during the delay between diagnosis and surgery, the tumors practically doubled in size every 10 days.
  • We believe the possibility of rapid growth of these tumors implies that treatment should be conducted as soon as possible.
  • [MeSH-major] Infant, Premature, Diseases / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Abdominal Abscess / diagnosis. Cell Division. Diagnostic Errors. Disease Progression. Early Diagnosis. Enterocolitis, Necrotizing / complications. Enterocolitis, Necrotizing / drug therapy. Enterocolitis, Necrotizing / ultrasonography. Female. Humans. Incidental Findings. Infant. Infant, Newborn. Intestinal Obstruction / etiology. Intestinal Obstruction / surgery. Malnutrition / complications. Nephrectomy. Remission Induction. Tomography, X-Ray Computed. Tumor Burden

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  • (PMID = 19684525.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Kianmanesh R, O'toole D, Sauvanet A, Ruszniewski P, Belghiti J: [Surgical treatment of gastric, enteric, and pancreatic endocrine tumors Part 1. Treatment of primary endocrine tumors]. J Chir (Paris); 2005 May-Jun;142(3):132-49
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  • [Title] [Surgical treatment of gastric, enteric, and pancreatic endocrine tumors Part 1. Treatment of primary endocrine tumors].
  • [Transliterated title] Traitement chirurgical des tumeurs endocrines gastro-entéro-pancréatiques.
  • Endocrine tumors (ET) of the digestive tract (formerly called neuroendocrine tumors) are rare.
  • They are classified into two principal types: gastrointestinal ET's (formerly called carcinoid tumors) which are the most common, and pancreaticoduodenal ET's.
  • Poorly-differentiated ET's have a poor prognosis and are treated by chemotherapy.
  • Surgical excision is the only curative treatment of well-differentiated ET's.
  • The surgical goals are to: 1. prolong survival by resecting the primary tumor and any nodal or hepatic metastases, 2. control the symptoms related to hormonal secretion, 3. prevent or treat local complications.
  • The most common sites of gastrointestinal ET's ( carcinoids) are the appendix and the rectum; these are often small (<1 cm), benign, and discovered fortuitously at the time of appendectomy or colonoscopic removal.
  • Ileal ET's, even if small, are malignant, frequently multiple, and complicated in 30-50% of cases by bowel obstruction, mesenteric invasion, or bleeding.
  • Insulinoma and gastrinoma (cause of the Zollinger-Ellison syndrome) are the most common functional ET's. 80% are sporadic; in these cases, tumor size, location, and malignant potential determine the type of resection which may vary from a simple enucleation to a formal pancreatectomy.
  • In 10-20% of cases, pancreaticoduodenal ET presents in the setting of multiple endocrine neoplasia (NEM type I), an autosomal-dominant genetic disease with multifocal endocrine involvement of the pituitary, parathyroid, pancreas, and adrenal glands.
  • For insulinoma with NEM-I, enucleation of lesions in the pancreatic head plus a caudal pancreatectomy is the most appropriate procedure.
  • For gastrinoma with NEM-I, the benefit of surgical resection for tumors less than 2-3 cm in size is not clear.
  • The lesions are frequently small, multiple, and widespread and recurrence is frequent after excision.
  • [MeSH-major] Carcinoid Tumor / surgery. Carcinoma, Islet Cell / surgery. Carcinoma, Neuroendocrine / surgery. Insulinoma / surgery. Intestinal Neoplasms / surgery. Multiple Endocrine Neoplasia Type 1 / surgery. Pancreatic Neoplasms / surgery. Stomach Neoplasms / surgery. Zollinger-Ellison Syndrome / surgery
  • [MeSH-minor] Adult. Gastrinoma / diagnosis. Gastrinoma / surgery. Glucagonoma / diagnosis. Glucagonoma / surgery. Humans. Liver Neoplasms / secondary. Lymphatic Metastasis. Malignant Carcinoid Syndrome / diagnosis. Malignant Carcinoid Syndrome / surgery. Multicenter Studies as Topic. Pancreatectomy. Postoperative Care. Postoperative Complications. Prognosis. Somatostatinoma / diagnosis. Somatostatinoma / surgery. Vipoma / diagnosis. Vipoma / surgery

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  • (PMID = 16142076.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 236
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19. Guimarães AP, Matos D, Segreto R, Forones NM: [Squamous cell carcinoma of the canal anal]. Arq Gastroenterol; 2001 Jan-Mar;38(1):9-13
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  • BACKGROUND: Anal cancer is an uncommon malignancy accounting for only a small (4%) percentage of intestinal cancer.
  • The authors described the clinical aspects and the treatment of the patients with squamous cell carcinoma of the canal anal.
  • RESULTS: The most common symptoms were rectal bleeding, local tumor and pain.
  • Six of them had previous anal benign disease and two had metastases at the diagnosis.
  • All were submitted to systemic chemotherapy with 5-fluorouracil and mitomycin and radiotherapy with 4500 cGy.
  • The chemo radiation can be a curable treatment in patients with local disease; conversely in patients with residual disease, abdominoperineal resection must be done.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma, Squamous Cell / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Sex Factors

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  • (PMID = 11582966.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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20. Knottenbelt CM, Simpson JW, Tasker S, Ridyard AE, Chandler ML, Jamieson PM, Welsh EM: Preliminary clinical observations on the use of piroxicam in the management of rectal tubulopapillary polyps. J Small Anim Pract; 2000 Sep;41(9):393-7
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  • The remaining cases were diagnosed as benign polyps.
  • All dogs were re-examined after four to six weeks of piroxicam therapy and the extent of haematochezia, tenesmus and faecal mucus production was reduced in all cases.
  • Medical management with piroxicam may provide a non-invasive treatment option for dogs with rectal polyp formation in which surgical treatment is likely to be associated with complications such as incontinence, infection and wound breakdown, or where the owner declines such treatment.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Intestinal Polyps / drug therapy. Intestinal Polyps / veterinary. Piroxicam / therapeutic use. Rectal Neoplasms / drug therapy. Rectal Neoplasms / veterinary
  • [MeSH-minor] Animals. Apoptosis. Cell Cycle. Dogs. Female. Male. Treatment Outcome

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  • (PMID = 11023124.001).
  • [ISSN] 0022-4510
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 13T4O6VMAM / Piroxicam
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21. Blanchard DK, Budde JM, Hatch GF 3rd, Wertheimer-Hatch L, Hatch KF, Davis GB, Foster RS Jr, Skandalakis JE: Tumors of the small intestine. World J Surg; 2000 Apr;24(4):421-9

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  • [Title] Tumors of the small intestine.
  • This collective review includes all available case reports and series of smooth muscle (stromal) tumors of the small intestine in the world literature from 1881 to 1996.
  • The peak incidence of smooth muscle tumors in the small intestine in both male and female patients was between the ages of 50 and 59.
  • Computed tomography was found to detect LM and LMS most successfully and had the additional advantage of locating metastatic disease.
  • The jejunum contained the highest numbers of smooth muscle tumors, followed by the ileum and then the duodenum, with malignant lesions in all locations typically attaining larger diameters than benign tumors.
  • For both benign and malignant smooth muscle tumors of the small intestine, surgery remains the treatment of choice, with little efficacy reported for irradiation, chemotherapy, or both.
  • [MeSH-major] Intestinal Neoplasms / classification. Intestine, Small / pathology. Leiomyoma / classification. Leiomyosarcoma / classification
  • [MeSH-minor] Age Factors. Female. Gastrointestinal Hemorrhage / physiopathology. Humans. Incidence. Lymphatic Metastasis. Male. Middle Aged. Sex Factors. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 10706914.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] UNITED STATES
  • [Number-of-references] 60
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22. Casper ES: Gastrointestinal stromal tumors. Curr Treat Options Oncol; 2000 Aug;1(3):267-73
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  • [Title] Gastrointestinal stromal tumors.
  • The nonepithelial, nonlymphoid tumors of the gastrointestinal tract are heterogeneous in terms of clinical presentation, behavior, pathology, and genetic features.
  • Concepts regarding these tumors have changed rapidly over the past decade as nomenclature has evolved.
  • Many of these tumors have no muscle differentiation, and designations such as leiomyoma or leiomyosarcoma are inappropriate for many of these neoplasms.
  • With an improved understanding of the biology of these tumors, gastrointestinal stromal tumor (GIST) is used as a specific term for tumors of the gastrointestinal tract that lack markers of myogenic differentiation, but stain positive for vimentin, and express CD34 and CD117, the product of the c-kit oncogene.
  • Both benign and malignant types are recognized.
  • In addition to myogenic tumors and GIST, gastrointestinal autonomic nerve tumors (GANT) are also recognized.
  • Complete en bloc surgical resection, when possible, is the cornerstone of therapy.
  • Metastasis tends to occur to the liver and within the peritoneal cavity, especially in patients whose tumors have ruptured spontaneously or been violated by the surgeon.
  • Operation may palliate patients with intestinal obstruction or other symptoms.
  • For patients with unresectable disease, the results with systemic chemotherapy have been dismal.
  • Treatment with doxorubicin/ifosfamide combinations is of dubious value.
  • Hepatic arterial embolization, with and without intra-arterial chemotherapy, results in regression of liver metastases in selected patients.
  • The impact of such treatment on outcome, however, is poorly studied.
  • Aggressive surgical resection of peritoneal metastases with intraperitoneal chemotherapy has been advocated, but requires formal study in large trials.
  • [MeSH-major] Gastrointestinal Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Clinical Trials as Topic. Humans. Radiotherapy. Stromal Cells / pathology. Survival Rate

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  • [Cites] Histopathology. 1991 Jul;19(1):1-11 [1916682.001]
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  • (PMID = 12057170.001).
  • [ISSN] 1527-2729
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 30
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23. Priest JR, Williams GM, Hill DA, Dehner LP, Jaffé A: Pulmonary cysts in early childhood and the risk of malignancy. Pediatr Pulmonol; 2009 Jan;44(1):14-30
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  • Asymptomatic cysts present a therapeutic dilemma: surgical intervention and "conservative" observation have advocates.
  • This unique biology of PPB can inform the cyst management decision.
  • The earliest manifestation of PPB is a malignant lung cyst in young children, clinically and radiographically indistinguishable from benign congenital lung cysts.
  • Histopathologic examination differentiates cystic PPB from the benign cystic variants.
  • Surgical excision of cystic PPB (with or without chemotherapy) cures approximately 85-90% of children.
  • Detailed family history may reveal the hallmarks of PPB in the patient or young relatives: a unique constellation of diseases including lung cysts, cystic nephroma, childhood cancers, stromal sex-chord ovarian tumors, seminomas or dysgerminomas, intestinal polyps, thyroid hyperplasias, and hamartomas.
  • These diagnoses predict that a lung cyst is more likely PPB than a benign congenital cyst.
  • [MeSH-major] Cysts / pathology. Lung Diseases / pathology. Lung Neoplasms / pathology. Pleural Neoplasms / pathology

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  • [Copyright] Copyright 2008 Wiley-Liss, Inc.
  • [CommentIn] Pediatr Pulmonol. 2010 Jan;45(1):103; author reply 104 [19960525.001]
  • (PMID = 19061226.001).
  • [ISSN] 1099-0496
  • [Journal-full-title] Pediatric pulmonology
  • [ISO-abbreviation] Pediatr. Pulmonol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 94
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24. Galimberti A, Compagnoni BM, Lezziero F, Grassi M, Gariboldi M, Ferrante F: [Gastrointestinal stromal tumours and acute haemorrhage: description of four cases]. Chir Ital; 2005 May-Jun;57(3):337-43
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  • [Transliterated title] Tumori stromali del tratto gastroenterico ed emorragia acuta: descrizione di quattro casi.
  • Gastrointestinal stromal tumours are uncommon neoplasias arising from stromal tissue of the intestinal wall.
  • The clinical symptoms of gastrointestinal stromal tumours are related to tumour size and are generally aspecific: acute or chronic bleeding, abdominal pain and palpable mass are some of the most common signs.
  • Surgery is the only curative therapy for gastrointestinal stromal tumours.
  • Chemotherapy or radiotherapy are of no use for metastatic disease, but good results are obtained with ST1571 in advanced disease.
  • In the absence of metastases, it is quite difficult to distinguish between benign and malignant lesions.
  • The most important prognostic factors are number of mitoses and tumour size.
  • [MeSH-major] Duodenal Neoplasms / surgery. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Hemorrhage / surgery. Gastrointestinal Stromal Tumors / complications. Gastrointestinal Stromal Tumors / surgery. Stomach Neoplasms / surgery
  • [MeSH-minor] Acute Disease. Aged. Endosonography. Humans. Male. Middle Aged. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16231822.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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25. Mathieu N: [Risk of long-term treatment with proton pump inhibitors]. Rev Prat; 2008 Sep 15;58(13):1451-4

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  • [Title] [Risk of long-term treatment with proton pump inhibitors].
  • [Transliterated title] Risques des traitements prolongés par les inhibiteurs de la pompe a protons.
  • Proton pump inhibitors (PPIs) have become the mainstay of therapy in acid-related upper gastrointestinal disorders including gastroesophageal reflux disease and peptic ulcer disease.
  • Alltough these medications are generally accepted as safe, the long-term clinical consequences of the inducing hypochlorhydria are not completely clear.
  • Gastric endocrine cell hyperplasia can occur in 10 to 30% of patients without carcinoid tumors.
  • Proton pump inhibitor-associated gastric polyps are totally benign tumors that should not be followed.
  • PPIs do not inhibit intestinal absorption of lipids, iron, phosphorus, magnesium or zinc from food but can affect vitamin B12 status in older patients.
  • [MeSH-minor] Bacterial Infections / chemically induced. Colonic Neoplasms / chemically induced. Gastric Acid / secretion. Gastrins / blood. Gastrins / drug effects. Humans. Polyps / chemically induced. Vitamin B 12 Deficiency / chemically induced

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  • (PMID = 18924330.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Gastrins; 0 / Proton Pump Inhibitors
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26. Colagrande S, Carbone SF, Carusi LM, Cova M, Villari N: Magnetic resonance diffusion-weighted imaging: extraneurological applications. Radiol Med; 2006 Apr;111(3):392-419
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  • The inherent sensitivity to motion and the magnetic susceptibility of Dw sequences nonetheless still create problems in the study of the abdomen due to artefacts caused by the heartbeat and intestinal peristalsis, as well as the presence of various parenchymal-gas interfaces.
  • With regard to the latter, although there are differences between benign forms [focal nodular hyperplasia (FNH), adenoma] and malignant forms [metastasis, hepatocellular carcinoma (HCC)] in their apparent diffusion coefficient (ADC) in the average values for histological type, there is a significant overlap in values when lesions are assessed individually, with the consequent problem of their correct identification.
  • Here it is possible to differentiate mucin-producing tumours of the pancreas from pseudocystic forms on the basis of ADC values even though the limited spatial resolution of Dw imaging does not enable the identification of small lesions.
  • Attempts have therefore been made to use Dw imaging in the characterization of soft-tissue tumours although the findings so far have been disputed.
  • Greater agreement has been found regarding sensitivity of the technique in assessing response of these tumours to chemotherapy: tumour necrosis is thought to increase ADC whereas the persistence of vital neoplastic tissue tends to lower it.
  • Nonetheless, even here, a moderate overlap between ADC values of the two types has been encountered.
  • [MeSH-minor] Bone Diseases / diagnosis. Echo-Planar Imaging. Humans. Kidney Diseases / diagnosis. Liver Diseases / diagnosis. Liver Neoplasms / diagnosis. Pancreatic Diseases / diagnosis. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 16683086.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 63
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27. Ho HS, Ong HS: A rare life-threatening complication of migrated nitinol self-expanding metallic stent (Ultraflex). Surg Endosc; 2004 Feb;18(2):347
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  • Although most migrated stents have a benign outcome, complications do occur.
  • Rare reports of intestinal obstruction have been confined to the stiff plastic and stainless-steel stents.
  • We report the first case of intestinal obstruction secondary to the pliable Nitinol SEMS (Ultraflex) migration.
  • [MeSH-major] Foreign-Body Migration / complications. Ileal Diseases / etiology. Intestinal Obstruction / etiology. Stents / adverse effects
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Aged. Alloys. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Deglutition Disorders / etiology. Deglutition Disorders / surgery. Device Removal. Epirubicin / administration & dosage. Equipment Design. Esophageal Neoplasms / complications. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / surgery. Fluorouracil / administration & dosage. Humans. Laparotomy. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Male. Postoperative Complications / etiology. Postoperative Complications / surgery

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  • (PMID = 15106627.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Alloys; 2EWL73IJ7F / nitinol; 3Z8479ZZ5X / Epirubicin; U3P01618RT / Fluorouracil
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28. Lipkin M: Early development of cancer chemoprevention clinical trials: studies of dietary calcium as a chemopreventive agent for human subjects. Eur J Cancer Prev; 2002 Aug;11 Suppl 2:S65-70
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  • Early cancer chemoprevention clinical trials in human subjects had to be carried out with large numbers of subjects studied for long durations, measuring cancer as an end point.
  • However new findings on abnormal epithelial cell growth and development during the multistage evolution of colonic tumors made it possible to carry out chemoprevention clinical trials in several stages, with fewer subjects studied for shorter durations, thus enabling investigators to analyze increasing numbers of chemopreventive agents and nutritional regimens in clinical trials.
  • Early- and late-stage intermediate biomarker studies in humans have strongly suggested utility for supplemental dietary calcium to inhibit the development of benign and subsequent malignant colonic neoplasms.
  • Preclinical experimental studies have further demonstrated the ability of increased dietary calcium to inhibit the evolution of colonic tumors when they were induced by targeted mutations, dietary factors, and particularly when given over a long duration of lifespan.
  • [MeSH-major] Anticarcinogenic Agents / administration & dosage. Calcium, Dietary / administration & dosage. Chemoprevention / methods. Clinical Trials as Topic. Colonic Neoplasms / prevention & control. Intestinal Mucosa / drug effects. Precancerous Conditions / drug therapy

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  • (PMID = 12570337.001).
  • [ISSN] 0959-8278
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Biomarkers; 0 / Calcium, Dietary
  • [Number-of-references] 44
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