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1. Alshayeb H, Wall BM: Non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis: rare case of long term remission with chemotherapy: a case report. Cases J; 2009;2:7201

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis: rare case of long term remission with chemotherapy: a case report.
  • INTRODUCTION: Although membranoproliferative glomerulonephritis has been reported to occur in association with non-Hodgkin's lymphoma, information concerning the long term effects of treatment of non-Hodgkin's lymphoma on the associated membranoproliferative glomerulonephritis is limited.
  • Kidney biopsy was consistent with membranoproliferative glomerulonephritis, type 1.
  • Bone marrow biopsy performed in the evaluation of periaortic lymphadenopathy, hepatosplenomegaly, and thrombocytopenia confirmed the diagnosis of low grade B-cell non-Hodgkin's lymphoma.
  • The patient's renal function improved and proteinuria resolved after initial treatment of non-Hodgkin's lymphoma with chemotherapy.
  • CONCLUSION: Membranoproliferative glomerulonephritis has been known to be associated with both chronic lymphocytic leukemia and non-Hodgkin's lymphoma, particularly with B cell lymphocytic type non-Hodgkin's lymphoma.
  • There is limited information available concerning the effects of treatment of non-Hodgkin's lymphoma on the progression of non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis.
  • This report presented a rare case of non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis, that continued to be in remission during eleven years of follow up after initial chemotherapy treatment of lymphoma.

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  • (PMID = 20181193.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827065
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2. Jorge S, Lopes JA, Gonçalves S, Esteves G, Alves do Carmo J: Acute kidney injury requiring dialysis: a very unusual presentation of non-Hodgkin's lymphoma. NDT Plus; 2010 Aug;3(4):338-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute kidney injury requiring dialysis: a very unusual presentation of non-Hodgkin's lymphoma.
  • Acute kidney injury due to lymphomatous infiltration of the kidneys is uncommon, and it is rarely the initial manifestation of the lymphoma.
  • Here, we present a case of lymphomatous infiltration of the kidneys resulting in acute kidney injury requiring dialysis, as the initial presentation of non-Hodgkin's lymphoma.
  • Renal biopsy established the diagnosis, and renal function completely recovered after chemotherapy.

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  • (PMID = 25949424.001).
  • [ISSN] 1753-0784
  • [Journal-full-title] NDT plus
  • [ISO-abbreviation] NDT Plus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4421531
  • [Keywords] NOTNLM ; acute kidney injury / non-Hodgkin’s lymphoma
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3. Jimenez VH: Coexistence between renal cell cancer and Hodgkin's lymphoma: a rare coincidence. BMC Urol; 2006;6:10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence between renal cell cancer and Hodgkin's lymphoma: a rare coincidence.
  • BACKGROUND: Renal cell carcinoma is the most common kidney tumor in adults and accounts for approximately 3% of adult malignancies.
  • In addition, treatment associated second malignancies (usually leukemias and lymphomas but also solid tumors) have been described in long term survivors of Hodgkin's lymphoma (HL), Non Hodgkin's lymphoma and in various pediatric tumors.
  • We performed a thorax CT scan that showed lymph nodes enlargement and subsequently by presence of abdominal pain was performed an abdominal and pelvis CT scan that showed a right kidney tumor of 4 x 5 cms besides of abdominal lymph nodes enlargement.
  • A radical right nephrectomy was designed and Hodgkin's lymphoma was diagnosed in the abdominal lymph nodes while renal cell tumor exhibited a renal cell cancer.
  • CONCLUSION: We described the first case reported in the medical literature of the coexistence between Hodgkin's lymphoma and renal cell cancer.
  • Previous reports have shown the relationship of lymphoid neoplasms with solid tumors, but they have usually described secondary forms of cancer related to chemotherapy.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Hodgkin Disease / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis

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  • (PMID = 16549035.001).
  • [ISSN] 1471-2490
  • [Journal-full-title] BMC urology
  • [ISO-abbreviation] BMC Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1435921
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4. Roldán-Valadez E, Ortega-López N, Cervera-Ceballos E, Valdivieso-Cárdenas G, Vega-González I, Granados-García M: Whole-body (18)F-FDG PET/CT in primary non-Hodgkin's lymphoma of the thyroid associated with Hashimoto's thyroiditis and bilateral kidney infiltration. Rev Esp Med Nucl; 2008 Jan-Feb;27(1):34-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Whole-body (18)F-FDG PET/CT in primary non-Hodgkin's lymphoma of the thyroid associated with Hashimoto's thyroiditis and bilateral kidney infiltration.
  • Due to the history of Hashimoto's thyroiditis and a rapid increase in size of the thyroid gland, diagnoses of thyroid lymphoma and anaplastic thyroid cancer were considered.
  • Fine needle aspiration was insufficient for diagnosis, and the product of thyroidectomy confirmed the diagnosis of diffuse large B-cell lymphoma.
  • A positron emission tomography/computed tomography scan was performed in our institution for staging, revealing nodal and extranodal metastasis.
  • Chemotherapy using cyclophosphamide, vincristine and dexamethasone (COP modified) led to a dramatic response of the tumor and a complete resolution of compressive symptoms.
  • [MeSH-major] Diagnostic Errors. Hashimoto Disease / radionuclide imaging. Kidney / pathology. Lymphoma, Large B-Cell, Diffuse / radionuclide imaging. Positron-Emission Tomography. Thyroid Neoplasms / radionuclide imaging. Tomography, X-Ray Computed. Whole Body Imaging
  • [MeSH-minor] Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Dexamethasone / administration & dosage. Female. Fluorodeoxyglucose F18. Goiter, Nodular / diagnosis. Humans. Radiopharmaceuticals. Remission Induction. Thyroidectomy. Thyroxine / therapeutic use. Vincristine / administration & dosage

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  • (PMID = 18208780.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 8N3DW7272P / Cyclophosphamide; Q51BO43MG4 / Thyroxine
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5. García-Suárez J, de Miguel D, Krsnik I, Barr-Alí M, Hernanz N, Burgaleta C: Spontaneous gas gangrene in malignant lymphoma: an underreported complication? Am J Hematol; 2002 Jun;70(2):145-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous gas gangrene in malignant lymphoma: an underreported complication?
  • We report a case of spontaneous gas gangrene (SGG), the most rapidly progressive form of clostridial infection, in a patient with non-Hodgkin's lymphoma (NHL).
  • A 43-year-old man with NHL developed fatal C. perfringens-associated SGG and massive hemolysis during induction chemotherapy.
  • Common features of all reports are a delayed diagnosis and a fatal outcome.
  • Awareness of this condition should result in prompt antibiotic therapy at the onset of typical presenting symptoms in any lymphoma patient, especially if risk factors are present.
  • [MeSH-major] Gas Gangrene / complications. Lymphoma, Non-Hodgkin / complications
  • [MeSH-minor] Acute Kidney Injury / etiology. Adult. Clostridium perfringens. Disseminated Intravascular Coagulation / etiology. Fatal Outcome. Hemolysis. Humans. Male. Risk Factors

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  • [Copyright] Copyright 2002 Wiley-Liss, Inc.
  • (PMID = 12111788.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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6. Pagano L, Mele L, Fianchi L, Melillo L, Martino B, D'Antonio D, Tosti ME, Posteraro B, Sanguinetti M, Trapè G, Equitani F, Carotenuto M, Leone G: Chronic disseminated candidiasis in patients with hematologic malignancies. Clinical features and outcome of 29 episodes. Haematologica; 2002 May;87(5):535-41
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  • BACKGROUND AND OBJECTIVES: To evaluate the characteristics of patients affected by hematologic malignancies who developed a chronic disseminated candidiasis (CDC), and to ascertain the factors that influenced the outcome, in a retrospective study conducted between January 1990 and December 2000, in 4 Hematology Divisions.
  • RESULTS: Twenty-eight patients (male/female 14/14; average age 42 years, range 12-67) developed a CDC.
  • Twenty had acute myeloid leukemia, 5 had acute lymphocytic leukemia and 3 had non-Hodgkin's lymphoma.
  • All patients received chemotherapy, including cytarabine for 21 of them (75%).
  • Before the infection, 22 patients (79%) were neutropenic (absolute neutrophil count < 0.5 x 10(9)/L) for an average of 20 days (8-36), but at CDC diagnosis only 3 patients (11%) were neutropenic.
  • Before diagnosis of CDC, 9 patients (32%) had a candidemia.
  • Ten patients had other organs involved: lung in 6 patients (21%), kidney in 4 patients (14%), other sites 2 patients (7%).
  • Abdominal ultrasonography was positive in 96% of patients (27/28), and abdominal computed tomography-scan was positive in 100% of cases in which it was performed (21/21).
  • By 30 days after diagnosis 4 patients had died, 1 from infection, and 3 progression of the hematologic malignancy without signs of active CDC.
  • Within 3 months from diagnosis 14 out of the remaining 24 patients (58%) received further chemotherapy: in particular, 2 patients underwent transplantation procedures.
  • The major problem of this fungal complication is correlated to the delay in the following treatment for the hematologic malignancy with a high risk of progression of malignancy.
  • [MeSH-major] Candidiasis / diagnosis. Hematologic Neoplasms / microbiology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Chronic Disease. Female. Humans. Male. Middle Aged. Opportunistic Infections / diagnosis. Opportunistic Infections / drug therapy. Opportunistic Infections / etiology. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 12010669.001).
  • [ISSN] 0390-6078
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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7. Tadokoro J, Gunji H, Handa T, Aoyagi M, Nakamura Y, Saito K, Furusawa S: [Primary renal non-Hodgkin's lymphoma presenting as immune thrombocytopenia]. Rinsho Ketsueki; 2001 Jan;42(1):41-6
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  • [Title] [Primary renal non-Hodgkin's lymphoma presenting as immune thrombocytopenia].
  • Computed tomography of the abdomen showed enlargement of the bilateral kidneys with multiple low-density areas, although neither lymphadenopathy nor hepatosplenomegaly was evident.
  • After amelioration of the thrombocytopenia by prednisolone therapy, open renal biopsy was performed and a diagnosis of diffuse large B-cell non-Hodgkin's lymphoma was made.
  • The patient achieved complete remission after CHOP therapy.
  • This was thought to be a rare case of primary renal non-Hodgkin's lymphoma initially presenting as immune thrombocytopenia, which was treated successfully by chemotherapy.
  • [MeSH-major] Kidney Neoplasms / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Thrombocytopenia / etiology

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  • (PMID = 11235133.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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8. Ogino J, Kawakatsu C, Hirasawa A, Sato T, Kawamura S, Nishikawa T, Wakabayashi Y: [Primary renal non-Hodgkin's lymphoma presenting as massive macrohematuria and bladder tamponade]. Rinsho Ketsueki; 2001 Nov;42(11):1101-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary renal non-Hodgkin's lymphoma presenting as massive macrohematuria and bladder tamponade].
  • Abdominal ultrasonography and computed tomography revealed bilateral renal tumors.
  • Percutaneous needle biopsy of the left renal tumor was performed, and the final diagnosis was non-Hodgkin's lymphoma (diffuse mixed, B cell type, CSIIA).
  • After six courses of chemotherapy, the tumor lesions were markedly reduced, and at present there is no evidence of recurrence.
  • [MeSH-major] Hematuria / etiology. Kidney Neoplasms / complications. Lymphoma, Non-Hodgkin / complications. Urinary Bladder Diseases / etiology

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  • (PMID = 11808078.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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9. Taylor AL, Bowles KM, Callaghan CJ, Wimperis JZ, Grant JW, Marcus RE, Bradley JA: Anthracycline-based chemotherapy as first-line treatment in adults with malignant posttransplant lymphoproliferative disorder after solid organ transplantation. Transplantation; 2006 Aug 15;82(3):375-81
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  • [Title] Anthracycline-based chemotherapy as first-line treatment in adults with malignant posttransplant lymphoproliferative disorder after solid organ transplantation.
  • BACKGROUND: Recommended first-line treatment for posttransplant lymphoproliferative disorder (PTLD) is reduction in immunosuppressive therapy, irrespective of histopathological type.
  • Second-line treatment with chemotherapy is generally reserved for tumors that fail to respond to reduced immunosuppression.
  • In view of the similarities between monomorphic PTLD and non-Hodgkin's lymphoma in the general population, our policy is to treat monomorphic PTLD with anthracycline-based chemotherapy as first-line treatment.
  • METHODS: A retrospective single-center analysis of 18 adults who developed PTLD following liver or kidney transplantation was undertaken, with particular emphasis on tumor histology, treatment received, and clinical outcome.
  • RESULTS: Of the 18 patients with PTLD, 13 had high-grade malignant lymphoma on diagnostic biopsy and received anthracycline-based chemotherapy and reduction in immunosuppression as first-line therapy.
  • Nine (69%) of the 13 patients achieved complete remission and eight (62%) remained in complete remission five years after diagnosis.
  • There was no graft loss from rejection or drug toxicity.
  • Four (22%) patients had polymorphic PTLD on diagnostic biopsy (of which two were re-classified as monomorphic) and one had a low-grade malignant lymphoma.
  • All five patients were treated by reduction in immunosuppression without chemotherapy and were in complete remission at a median of two years after diagnosis.
  • Overall, complete remission was seen in 14 out of 18 patients (78%) at one year following diagnosis.
  • CONCLUSION: The use of anthracycline-based chemotherapy and reduction of immunosuppression as first-line treatment in adults with monomorphic PTLD is well tolerated and achieves sustained complete remission in around 70% of patients with a low risk of graft loss.
  • [MeSH-major] Anthracyclines / therapeutic use. Kidney Transplantation. Lymphoma / drug therapy. Lymphoma / pathology. Lymphoproliferative Disorders / drug therapy. Lymphoproliferative Disorders / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Female. Humans. Male. Middle Aged. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 16906036.001).
  • [ISSN] 0041-1337
  • [Journal-full-title] Transplantation
  • [ISO-abbreviation] Transplantation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anthracyclines
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10. Turk HM, Ozet A, Ozturk M, Komurcu S, Kuzhan O, Arpaci F, Ozturk B, Safali M: Isolated renal relapse of a case with non-Hodgkin's lymphoma. Med Oncol; 2010 Jun;27(2):434-8
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  • [Title] Isolated renal relapse of a case with non-Hodgkin's lymphoma.
  • Transthoracic needle aspiration from the mass revealed findings consistent with nodular sclerosis variety of Hodgkin's disease.
  • Ten months later CT scan showed three hypodense masses in the right kidney.
  • Ultrasound guided renal biopsy revealed diffuse large B cell lymphoma.
  • Retrospective re-evaluation of the archival specimens of the mediastinal mass was also consistent with diffuse large B cell lymphoma.
  • After induction chemotherapy (four cycles of DHAP) she underwent high dose chemotherapy (BEAM) and autologous peripheral blood stem cell transplantation.
  • In conclusion, renal involvement during advanced lymphoma is quite common but isolated renal relapse in NHL is a rare situation.
  • Although renal infiltration generally shows a poor prognosis, long-term survival may be achieved with high dose chemotherapy and autologous peripheral blood stem cell transplantation.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Kidney Neoplasms / therapy. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / therapy

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  • (PMID = 19437146.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Akcali Z, Ozyilkan O, Moray G, Emiroglu R, Haberal M: Treatment results in renal transplant recipients with non-Hodgkin's lymphoma. Transplant Proc; 2003 Jun;35(4):1404-7
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  • [Title] Treatment results in renal transplant recipients with non-Hodgkin's lymphoma.
  • The purpose of this study was to investigate the incidence of non-Hodgkin's lymphoma (NHL), response to treatment, and survival time in renal transplant recipients at our center who developed this form of neoplasia.
  • Complete remission was achieved in eight cases, and five of these individuals were still alive at the time of writing.
  • (1) progressive gastric adenocarcinoma 9 years after being diagnosed with NHL, (2) stage III NHL cured with chemotherapy, but died of infection 2 years after NHL diagnosis, and (3) recurrent intestinal lymphoma, with death during second line chemotherapy.
  • The median time from transplantation to diagnosis of NHL was 66 months.
  • At the time of writing, the median survival time for the eight patients who achieved complete remission was 41.5 months.
  • The study showed that treatment of localized disease (skin or intestinal NHL) with surgery and/or radiotherapy/chemotherapy leads to complete remission and long survival times; however, patients in remission are at risk for other causes of death.
  • [MeSH-major] Kidney Transplantation / statistics & numerical data. Lymphoma, Non-Hodgkin / epidemiology. Postoperative Complications / epidemiology
  • [MeSH-minor] Adult. Cadaver. Female. Humans. Incidence. Living Donors. Male. Middle Aged. Survival Analysis. Time Factors. Tissue Donors. Turkey / epidemiology

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  • (PMID = 12826172.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Gellrich J, Hakenberg OW, Naumann R, Manseck A, Lossnitzer A, Wirth MP: Primary renal non-Hodgkin's lymphoma - a difficult differential diagnosis. Onkologie; 2002 Jun;25(3):273-7
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  • [Title] Primary renal non-Hodgkin's lymphoma - a difficult differential diagnosis.
  • INTRODUCTION: Primary renal lymphoma (PRL) as a clinical entity is not undisputed because the kidneys do not contain lymphatic tissue and the mechanism of development of PRLs is unclear.
  • Although there are no clearly defined diagnostic criteria for renal lymphomas, abdominal and thoracic computed tomography as well as renal and bone marrow biopsy are recommended.
  • 3 cases of renal lymphoma are reported and their diagnosis and management discussed.
  • CASE REPORTS: Between 1996 and 2001, 3 male patients with renal lymphoma were diagnosed and treated at our institution.
  • Patient No. 2 presented with a large renal mass which, on biopsy, was diagnosed as a lymphoma.
  • Patient No. 3 showed lymphoma on renal biopsy and bone marrow involvement.
  • All 3 patients were treated with systemic chemotherapy which resulted in death of disease in 2 patients and a complete remission in 1 patient after adjuvant radiotherapy and nephrectomy.
  • If diagnosed early, cure is possible, and multimodal treatment should be considered.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Lymphoma, B-Cell / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Bone Marrow / pathology. Cyclophosphamide / administration & dosage. Diagnosis, Differential. Diagnostic Imaging. Doxorubicin / administration & dosage. Hematuria / etiology. Humans. Kidney / pathology. Male. Middle Aged. Prednisone / administration & dosage. Vincristine / administration & dosage

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  • [Copyright] Copyright 2002 S. Karger GmbH, Freiburg
  • (PMID = 12119463.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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13. Janssen-Heijnen ML, van Spronsen DJ, Lemmens VE, Houterman S, Verheij KD, Coebergh JW: A population-based study of severity of comorbidity among patients with non-Hodgkin's lymphoma: prognostic impact independent of International Prognostic Index. Br J Haematol; 2005 Jun;129(5):597-606
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A population-based study of severity of comorbidity among patients with non-Hodgkin's lymphoma: prognostic impact independent of International Prognostic Index.
  • Over 60% of patients aged over 70 years, diagnosed with non-Hodgkin's lymphoma (NHL) in the Netherlands have serious comorbidity.
  • We studied the independent influence of comorbidity on choice of treatment, dose reductions, treatment-related toxicity and prognosis, using data from a random sample of 381 patients from the population-based Eindhoven Cancer Registry.
  • About 45% of patients over 60 years of age with NHL had high impact comorbidity at the time of cancer diagnosis.
  • The proportion of patients with aggressive NHL who received chemotherapy decreased from 85% in patients aged 40-60 years to 70% in those over 60 years.
  • About 65% of systematically treated patients with aggressive NHL suffered from treatment-related toxicity.
  • Dose reductions are frequently unavoidable for patients with severe comorbidity, poor performance status or chemotherapy-related toxicity.
  • Whether the less frequent prescription of (full dose) chemotherapy for patients with advanced age and/or with comorbidity is justified remains a question for debate.
  • [MeSH-major] Diabetes Mellitus, Type 1 / complications. Heart Diseases / complications. Kidney Failure, Chronic / complications. Lymphoma, Non-Hodgkin / complications. Neoplasms / complications. Pulmonary Disease, Chronic Obstructive / complications
  • [MeSH-minor] Adult. Age Factors. Aged. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Female. Humans. Logistic Models. Male. Middle Aged. Netherlands. Prognosis. Survival Rate. Treatment Outcome


14. Geetha N, Jayasree K, Ittiyavirah AK, Lali VS, Nair MK: Renal relapse in bilateral synchronous testicular lymphoma. Am J Clin Oncol; 2000 Jun;23(3):290-1
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  • [Title] Renal relapse in bilateral synchronous testicular lymphoma.
  • Bilateral synchronous testicular lymphoma is an uncommon presentation of non-Hodgkin's lymphoma.
  • A young man with non-Hodgkin's lymphoma of both testes synchronously is described here.
  • He underwent bilateral orchiectomy, received chemotherapy, and was in complete remission when there was a relapse in the kidneys.
  • Salvage chemotherapy was given.
  • The patient developed progression of the residual lesion subsequently and was started on palliation with chlorambucil and prednisolone.
  • He was alive at 34 months after diagnosis with disease.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Kidney Neoplasms / drug therapy. Lymphoma, Non-Hodgkin / drug therapy. Neoplasms, Multiple Primary / drug therapy. Neoplasms, Multiple Primary / surgery. Orchiectomy. Testicular Neoplasms / drug therapy. Testicular Neoplasms / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Humans. Male. Prednisolone / administration & dosage. Recurrence. Remission Induction. Salvage Therapy. Tomography, X-Ray Computed. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 10857896.001).
  • [ISSN] 0277-3732
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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15. Kose F, Sakalli H, Mertsoylu H, Sezer A, Kocer E, Tokmak N, Kilinc F, Ozyilkan O: Primary renal lymphoma: report of four cases. Onkologie; 2009 Apr;32(4):200-2
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  • [Title] Primary renal lymphoma: report of four cases.
  • BACKGROUND: Although secondary renal involvement from systemic lymphoma is very frequent, primary renal lymphoma is a rare entity.
  • CASE REPORTS: Here, we report 4 cases of primary renal lymphoma presenting with unilateral renal masses, which after radiological and clinical examination were assumed to be renal cell carcinoma.
  • 3 patients were diagnosed with Non-Hodgkin's lymphoma by nephrectomy and one patient was diagnosed by open renal biopsy.
  • Histopathological subtypes were diffuse large B cell lymphoma in 2 cases and non-Hodgkin's lymphoma of small B cell type in the others.
  • While 3 of the patients were treated with systemic chemotherapy, the fourth patient refused chemotherapy.
  • 2 patients (no. 2 and 3) were still in complete remission and were followed regularly in the second and first year after diagnosis, respectively.
  • CONCLUSIONS: Since it is difficult to diagnose primary renal lymphoma, most patients with this kind of tumor undergo radical nephrectomy, and diagnosis of primary renal lymphoma is delayed.
  • The authors believe that both the delayed diagnosis due to anatomical difficulties and the histological aggressive characteristics of this disease are equally responsible for the poor outcome in the case of primary renal lymphoma.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Kidney Neoplasms / therapy. Lymphoma / diagnosis. Lymphoma / therapy

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19372716.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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16. Katsura Y, Suzukawa K, Kojima H, Yoshida C, Shimizu S, Mukai H, Hasegawa Y, Imagawa S, Mori N, Nagasawa T: Cytotoxic T-cell lymphoma arising in Behçet disease. Int J Hematol; 2003 Apr;77(3):282-5
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  • [Title] Cytotoxic T-cell lymphoma arising in Behçet disease.
  • The case of a 49-year-old man with peripheral T-cell lymphoma arising in Behcet disease (BD) is reported.
  • A diagnosis of incomplete BD was made, and the patient was treated with immunosuppressive agents for 9 months.
  • A left perirenal mass emerged, and a computed tomography-guided needle biopsy of the tumor revealed the infiltration of small- and medium-sized lymphoma cells.
  • A diagnosis of non-Hodgkin's lymphoma (diffuse medium, T-cell) was made.
  • Standard combination chemotherapy diminished the perirenal and orbital lesions.
  • Lymphoma cell infiltration in the esophagus was detected after chemotherapy, and the patient died of massive bleeding from the gastrointestinal tract.
  • Non-Hodgkin's lymphoma is rarely associated with BD, and only 7 cases have been reported in the literature.
  • We have summarized the published case reports of malignant lymphoma arising in BD.
  • To our knowledge, this case report is the first to describe cytotoxic T-cell lymphoma arising in Behçet disease.
  • [MeSH-major] Behcet Syndrome / complications. Lymphoma, T-Cell / etiology. T-Lymphocytes, Cytotoxic / pathology
  • [MeSH-minor] Antigens, CD / analysis. Clone Cells / immunology. Humans. Immunosuppressive Agents / therapeutic use. Kidney Neoplasms. Male. Middle Aged. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 12731673.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Immunosuppressive Agents
  • [Number-of-references] 25
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17. Dufau JP, Patte JH, Ceccaldi B, Fagot T, Sylvestre A, Le Vagueresse R: [Non-Hodgkin lymphoma mimicking renal carcinoma: apropos of 1 case of follicular lymphoma]. Ann Pathol; 2000 May;20(3):253-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Non-Hodgkin lymphoma mimicking renal carcinoma: apropos of 1 case of follicular lymphoma].
  • Primary renal non-Hodgkin's lymphoma (NHL) is unusual, in contrast to the frequent renal involvement in disseminated NHL.
  • We report a case of follicular lymphoma presenting initially as a renal mass.
  • The median age at diagnosis is 64 years with a male predominance.
  • The existence of renal non-Hodgkin lymphoma mimicking renal carcinoma must be recognized.
  • Nephrectomy followed by chemotherapy permits long disease free survival.
  • [MeSH-major] Kidney Neoplasms. Lymphoma, Follicular / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Humans. Nephrectomy. Tomography, X-Ray Computed


18. Alkhunaizi AM, Daabil RA, Dawamneh MF: Acute kidney injury secondary to lymphomatous infiltration and the role of kidney biopsy. Saudi Med J; 2008 Dec;29(12):1808-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute kidney injury secondary to lymphomatous infiltration and the role of kidney biopsy.
  • We report a 47-year-old male patient who developed acute kidney injury requiring hemodialysis, associated with massive enlargement of both kidneys.
  • A kidney biopsy established the diagnosis of non-Hodgkin's lymphoma.
  • The patient received chemotherapy with good response.
  • This case demonstrates that the kidney could be the primary organ involved in non-Hodgkin's lymphoma.
  • In addition, we have shown that renal biopsy is adequate to make a diagnosis of lymphoma without the need to do more invasive testing.
  • [MeSH-major] Acute Kidney Injury / etiology. Acute Kidney Injury / pathology. Kidney / pathology. Lymphoma, Non-Hodgkin / complications. Lymphoma, Non-Hodgkin / pathology
  • [MeSH-minor] Biopsy. Humans. Kidney Glomerulus / pathology. Male. Middle Aged

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  • (PMID = 19082238.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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19. Ozaltin F, Yalçin B, Orhan D, Sari N, Caglar M, Besbas N, Bakkaloglu A: An unusual cause of acute renal failure: renal lymphoma. Pediatr Nephrol; 2004 Aug;19(8):912-4
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  • [Title] An unusual cause of acute renal failure: renal lymphoma.
  • Renal involvement is a common finding in non-Hodgkin's lymphoma (NHL).
  • The diagnosis of B-cell NHL was established by tru-cut biopsy of the kidneys and the patient had an excellent response to high-dose chemotherapy with no major complication.
  • The presence of extrarenal involvement in the testes and the retroperitoneal lymph nodes made the diagnosis of primary renal lymphoma debatable.
  • However, considering the delay in diagnosis and the high proliferative rate of B-cell NHL, we might postulate that the disease had originated primarily in the kidneys.
  • We recommend that in NHL cases with severe renal involvement, full-dose chemotherapy should be instituted with meticulous clinical and laboratory follow-up in order to improve clinical and renal failure status rapidly and to avoid further dissemination of NHL.
  • [MeSH-major] Acute Kidney Injury / etiology. Kidney Neoplasms / complications. Lymphoma, B-Cell / complications

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  • (PMID = 15206030.001).
  • [ISSN] 0931-041X
  • [Journal-full-title] Pediatric nephrology (Berlin, Germany)
  • [ISO-abbreviation] Pediatr. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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20. Snanoudj R, Durrbach A, Leblond V, Caillard S, Hurault De Ligny B, Noel C, Rondeau E, Moulin B, Mamzer-Bruneel MF, Lacroix C, Charpentier B: Primary brain lymphomas after kidney transplantation: presentation and outcome. Transplantation; 2003 Sep 27;76(6):930-7
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  • [Title] Primary brain lymphomas after kidney transplantation: presentation and outcome.
  • BACKGROUND: Non-Hodgkin's lymphoma is the second most frequent neoplasia following solid-organ transplantation.
  • METHODS: Twenty-five kidney transplant patients with histologically proven PTBL from 11 French centers were retrospectively investigated.
  • Median overall delay between transplantation and lymphoma was 18 months (4-264).
  • Six of 10 patients with late posttransplantation brain lymphomas (PTBL) occurrence (>3 years) had been recently switched from azathioprine to mycophenolate mofetil (median switch lymphoma delay 14 months).
  • Cerebral computed tomography (CT) scans and magnetic resonance imaging (MRI) revealed multifocal lesions (n=18), with a ring contrast enhancement (n=20) similar to cerebral abscesses, as observed in HIV-related brain lymphomas.
  • Histology showed large B-cell non-Hodgkin's lymphoma in 87.5% of cases; Epstein-Barr virus (EBV) was detected in 95%.
  • After lymphoma diagnosis, immunosuppressive treatment was reduced in all patients, and all but one received complementary treatment by surgery (n=2), anti-CD21 antibodies (n=2), chemotherapy including high-dose intravenous methotrexate (n=7), encephalic radiotherapy (n=5), or chemotherapy plus radiotherapy (n=8).
  • Treatment by radiotherapy is associated with better survival.
  • [MeSH-major] Brain Neoplasms / epidemiology. Kidney Transplantation / adverse effects. Lymphoma / epidemiology
  • [MeSH-minor] Adult. Antilymphocyte Serum / therapeutic use. Female. Follow-Up Studies. Humans. Immunosuppressive Agents / therapeutic use. Intracranial Hypertension / epidemiology. Male. Middle Aged. Nervous System Diseases / epidemiology. Postoperative Complications. Retrospective Studies. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 14508356.001).
  • [ISSN] 0041-1337
  • [Journal-full-title] Transplantation
  • [ISO-abbreviation] Transplantation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antilymphocyte Serum; 0 / Immunosuppressive Agents
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21. van den Bosch J, Kropman RF, Blok P, Wijermans PW: Disappearance of a mucosa-associated lymphoid tissue (MALT) lymphoma of the urinary bladder after treatment for Helicobacter pylori. Eur J Haematol; 2002 Mar;68(3):187-8
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  • [Title] Disappearance of a mucosa-associated lymphoid tissue (MALT) lymphoma of the urinary bladder after treatment for Helicobacter pylori.
  • A non-Hodgkin's lymphoma of the MALT type of the urinary bladder, stage I A-E, was diagnosed.
  • Radiotherapy was advised, but the patient refused this kind of treatment.
  • Because of the known relationship of a gastric MALT lymphoma and Helicobacter pylori, the patient was treated with HP eradication therapy.
  • Afterwards the lymphoma disappeared.
  • This is the first known case of the disappearance of a MALT lymphoma of the urinary bladder after treatment with HP eradication therapy.
  • [MeSH-major] Helicobacter Infections / drug therapy. Helicobacter pylori. Lymphoma, B-Cell, Marginal Zone / microbiology. Urinary Bladder Neoplasms / microbiology
  • [MeSH-minor] Biopsy. Humans. Immunophenotyping. Kidney Calculi / diagnosis. Kidney Calculi / therapy. Male. Middle Aged. Remission Induction. Urinary Bladder / immunology. Urinary Bladder / pathology

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  • (PMID = 12028368.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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22. Maino A, Garigali G, Grande R, Messa P, Fogazzi GB: Urinary balantidiasis: diagnosis at a glance by urine sediment examination. J Nephrol; 2010 Nov-Dec;23(6):732-7
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  • [Title] Urinary balantidiasis: diagnosis at a glance by urine sediment examination.
  • A 56-year-old Caucasian man with non-Hodgkin's lymphoma, who had previously been treated with prolonged intensive chemotherapy, was hospitalized for an acute and reversible kidney injury of multifactorial origin.
  • In spite of this, due to the previous chemotherapy, the patient was treated with oral metrodinazole.

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  • (PMID = 20349417.001).
  • [ISSN] 1121-8428
  • [Journal-full-title] Journal of nephrology
  • [ISO-abbreviation] J. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] Human balantidiasis
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23. Zimoń T, Jarmoliński T, Peregud-Pogorzelski J, Nowakowska J: [Acute renal failure as complication of neoplastic disease in children]. Pol Merkur Lekarski; 2002 Dec;13(78):497-9

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  • Three cases of acute renal failure (ARF) requiring renal replacement therapy (RRT) in the course of neoplastic disease were presented.
  • In 11-yr-old boy ARF was the first clinical presentation of non-Hodgkin's lymphoma.
  • Chemotherapy brought restoration of renal function.
  • As a conclusion we emphasize complex etiology of ARF in such patients as well as the necessity of early introduction of RRT and thorough diagnosis and proper management of the causes of impaired renal function.
  • [MeSH-major] Acute Kidney Injury. Renal Replacement Therapy / utilization
  • [MeSH-minor] Adolescent. Child. Diagnosis, Differential. Female. Humans. Leg / physiopathology. Leukemia, Myeloid, Acute / complications. Leukemia, Myeloid, Acute / therapy. Lymphoma, Non-Hodgkin / complications. Lymphoma, Non-Hodgkin / therapy. Male. Myosarcoma / complications. Myosarcoma / therapy. Time Factors

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  • (PMID = 12666450.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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24. Healy CM, Tobin AM, Kirby B, Flint SR: Oral lesions as an initial manifestation of dermatomyositis with occult malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Feb;101(2):184-7
Hazardous Substances Data Bank. VINCRISTINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Investigations for an occult malignancy in this patient resulted in the identification of a non-Hodgkin's lymphoma in her right kidney.
  • Commencement of chemotherapy rapidly resulted in complete resolution of her oral and skin lesions.
  • [MeSH-major] Dermatomyositis / complications. Gingivitis / etiology. Kidney Neoplasms / complications. Leukemia, B-Cell / complications. Oral Ulcer / etiology
  • [MeSH-minor] Aged. Antineoplastic Agents / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cyclophosphamide / administration & dosage. Diagnosis, Differential. Doxorubicin / administration & dosage. Female. Glucocorticoids / therapeutic use. Humans. Mouth Mucosa / pathology. Prednisolone / administration & dosage. Prednisolone / therapeutic use. Vincristine / administration & dosage

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  • Hazardous Substances Data Bank. DOXORUBICIN .
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  • (PMID = 16448919.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Glucocorticoids; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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25. Martín-Gómez MA, Peña M, Cabello M, Burgos D, Gutierrez C, Sola E, Acedo C, Bailén A, Gonzalez-Molina M: Posttransplant lymphoproliferative disease: a series of 23 cases. Transplant Proc; 2006 Oct;38(8):2448-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Between 1979 and 2005, this center performed 1614 kidney transplants, and 23 patients had PTLD.
  • Serology for Epstein Barr virus (EBV) was negative in nine patients at the time of transplant, and in five it became positive on diagnosis of PTLD.
  • The predominant disorder was non-Hodgkin's lymphoma (NHL), either polymorphous (n = 11) or monomorphous (n = 7).
  • The base therapy consisted of reducing or suspending calcineurin inhibitors and the addition of sirolimus and antivirals.
  • Three patients received rituximab, and five chemotherapy.
  • The disease progressed in 36% of the polymorphous NHL, in 67% of the monomorphous, and in 100% of the Hodgkin's lymphoma, whereas 10 patients had remission.
  • Renal function worsened on diagnosis in eight patients, and the graft was infiltrated in five (confirmed histologically).
  • We conclude that in most cases EBV is positive on diagnosis of the PTLD, an age older than 55 years affords a poor prognosis, and lymphocyte infiltration of the graft is common, as is worsening renal function.
  • [MeSH-major] Kidney Transplantation / adverse effects. Lymphoproliferative Disorders / epidemiology. Postoperative Complications / epidemiology
  • [MeSH-minor] Humans. Incidence. Kidney Function Tests. Retrospective Studies. Risk Factors. Survival Analysis

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  • (PMID = 17097963.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Liu GH, Li HZ, Wang HJ, Mao QZ, Xia M, Xie Y, Xue C, Wang H, Ji ZG: [Occurrence, types, and therapies of malignant tumors in recipients of renal transplantation]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2009 Jun;31(3):288-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Occurrence, types, and therapies of malignant tumors in recipients of renal transplantation].
  • OBJECTIVE: To investigate the types and therapies of malignancies in renal allograft recipients.
  • METHODS: We retrospectively analyzed the occurrence, types, and therapies of malignancies in 498 renal allograft recipients who had received operations in Peking Union Medical College Hospital from May 1986 to October 2008.
  • RESULTS: Among 498 renal allograft recipients, 18 patients (3.6% ) were diagnosed with malignancies, which included bladder cancer (n = 5), renal pyloric cancer or ureteric cancer (n = 4), leukemia or lymphoma (n = 3), hepatic cancer (n = 2), skin cancer, rectum carcinoma, pulmonary carcinoma and thymoma (n = 1 each).
  • One non-Hodgkin's lymphoma patient died 11 months after chemotherapy.
  • Five cases with advanced unresectable malignancies died 8 to 17 months after the diagnosis.
  • [MeSH-major] Kidney Transplantation. Neoplasms. Postoperative Complications

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  • (PMID = 19621511.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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27. Bates WD, Gray DW, Dada MA, Chetty R, Gatter KC, Davies DR, Morris PJ: Lymphoproliferative disorders in Oxford renal transplant recipients. J Clin Pathol; 2003 Jun;56(6):439-46
Hazardous Substances Data Bank. CYCLOSPORIN A .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Non-Hodgkin's lymphomas (NHLs) occur frequently during the first year after transplantation, more so in North America than in Europe.
  • METHODS: This study audited and correlated the demographic, clinical, pathological, and outcome features of post-transplant lymphoproliferative disorders (PTLDs) in a large centre in Oxford, and assessed whether the time of onset fitted more with the European or North American pattern.
  • RESULTS: There were 1383 renal transplants in the study period and 27 patients developed lymphoma: 26 NHLs and one Hodgkin's disease (1.95%).
  • The mean time of diagnosis after transplant was 46 months.
  • Management included reduction of immunosuppression, surgical excision, antiviral treatment, radiotherapy, and chemotherapy.
  • CONCLUSIONS: PTLDs occurred in 2% of renal transplant patients, presenting both in the first year in association with cyclosporin use, as in North America, but also in subsequent years, giving an overall presentation time later than the international mean.
  • [MeSH-major] Immunosuppression / adverse effects. Kidney Transplantation. Lymphoma / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Cyclosporine / adverse effects. Female. Humans. Immunosuppressive Agents / adverse effects. Male. Middle Aged. Postoperative Period. Prospective Studies. Registries. Treatment Outcome

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  • (PMID = 12783971.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
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28. Fukuno K, Tsurumi H, Yamada T, Oyama M, Moriwaki H: Graft failure due to hemophagocytic syndrome after autologous peripheral blood stem cell transplantation. Int J Hematol; 2001 Feb;73(2):262-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a female patient with B-cell non-Hodgkin's lymphoma (NHL) with graft failure due to HPS 12 days after autologous peripheral blood stem cell transplantation (PBSCT).
  • Autologous PBSCT was carried out during unconfirmed/uncertain complete remission according to the Cotswolds classification after 6 cycles of biweekly (cyclophosphamide, doxorubicin, vincristine, and prednisolone) therapy and 3 courses of salvage chemotherapy including etoposide.
  • The patient developed a high fever on day 2 post-PBSCT.
  • Although high-dose methylprednisolone therapy was continued, her white blood cell count further decreased to 0.3 x 10(9)/L, and the patient died of multiple organ failure on day 29 post-PBSCT.
  • A computed tomography scan did not identify recurrent NHL, and necropsy specimens from the bone marrow, liver, and kidney revealed no neoplastic infiltration.
  • HPS may have been induced by infection with methicillin-resistant Staphylococcus aureus rather than by lymphoma-associated HPS.
  • [MeSH-major] Hematopoietic Stem Cell Transplantation / adverse effects. Histiocytosis, Non-Langerhans-Cell / diagnosis. Histiocytosis, Non-Langerhans-Cell / etiology. Lymphoma, B-Cell / therapy

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  • (PMID = 11372742.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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