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1. Jun HJ, Kim WS, Yang JH, Yi SY, Ko YH, Lee J, Jung CW, Kang SW, Park K: Orbital infiltration as the first site of relapse of primary testicular T-cell lymphoma. Cancer Res Treat; 2007 Mar;39(1):40-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital infiltration as the first site of relapse of primary testicular T-cell lymphoma.
  • The pathologic diagnosis of the radical orchiectomy specimen was peripheral T-cell lymphoma, unspecified (PTCL-u).
  • After first-line chemotherapy with four courses of the CHOP regimen and this was followed by involved-field radiotherapy, he achieved complete remission.
  • Two months later, disease recurred to the left ciliary body of the left eye without evidence of involvement at other sites.
  • Although the patient received intensive chemotherapy with autologous hematopoietic stem cell transplantation, he ultimately died of leptomeningeal seeding.
  • Because both the central nervous system (CNS) and the orbit are sanctuary sites for chemotherapy, orbital infiltration of lymphoma should prompt physicians to evaluate involvement of the CNS and to consider performing prophylactic intrathecal chemotherapy as a treatment option.

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  • (PMID = 19746228.001).
  • [ISSN] 1598-2998
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2739356
  • [Keywords] NOTNLM ; Eye neoplasm / Non-Hodgkin's lymphoma / T cell lymphoma / Testes
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2. Cimino L, Chan CC, Shen D, Masini L, Ilariucci F, Masetti M, Asioli S, Sartori A, Cappuccini L: Ocular involvement in nasal natural killer T-cell lymphoma. Int Ophthalmol; 2009 Aug;29(4):275-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ocular involvement in nasal natural killer T-cell lymphoma.
  • PURPOSE: To describe the clinical, morphologic, and immunohistochemical features of a case of paranasal natural killer/T-cell lymphoma (NKTL) with ocular involvement.
  • In July she underwent a nasal computed tomography (CT) scan and multiple biopsies of the granulomatous tissue in the nasal fossae.
  • The diagnosis was NK/T non-Hodgkin's lymphoma nasal type, stage IV A.
  • In September after the diagnosis of lymphoma the patient underwent a bone marrow biopsy and thoracic and abdominal CT scan.
  • In October she started chemotherapy cycles.
  • RESULTS: A diagnosis of T-lymphoma cells in the vitreous was made; the tumor was most likely originating from her paranasal NKTL.
  • CONCLUSIONS: Nasal and paranasal sinus lymphomas are rare, but aggressive diseases with a tendency to invade tissues and spread to CNS, including the eye.
  • Ocular manifestations prior to systemic ones may be useful to monitor the response to therapy.
  • [MeSH-major] Eye / pathology. Lymphoma, T-Cell / pathology. Natural Killer T-Cells. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Fatal Outcome. Female. Fundus Oculi. Humans. Middle Aged. Neoplasm Invasiveness. Prednisone / therapeutic use. Recurrence. Uveitis / etiology. Vincristine / therapeutic use. Vitreous Body / pathology

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  • (PMID = 18438613.001).
  • [ISSN] 1573-2630
  • [Journal-full-title] International ophthalmology
  • [ISO-abbreviation] Int Ophthalmol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 EY000222-22
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
  • [Other-IDs] NLM/ NIHMS55130; NLM/ PMC2714878
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3. Thakker MM, Perez VL, Moulin A, Cremers SL, Foster CS: Multifocal nodular episcleritis and scleritis with undiagnosed Hodgkin's lymphoma. Ophthalmology; 2003 May;110(5):1057-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multifocal nodular episcleritis and scleritis with undiagnosed Hodgkin's lymphoma.
  • PURPOSE: To report the case of a patient with undiagnosed Hodgkin's lymphoma who presented with coexistent unilateral nodular episcleritis and scleritis.
  • RESULTS: A 20-year-old female presented with a 5-month history of redness and pain in her left eye, with associated symptoms of dyspnea, malaise, and fever.
  • The patient was found to have multifocal nodular episcleritis and scleritis that was not responsive to topical steroids or systemic nonsteroidal anti-inflammatory treatment.
  • A cervical lymph node biopsy showed Reed-Sternberg cells and a chronic lymphocytic infiltrate consistent with nodular sclerosing Hodgkin's lymphoma.
  • Systemic chemotherapy was instituted for the Hodgkin's disease; this therapy abolished the nodular scleritis.
  • CONCLUSIONS: This case raises the possibility of concurrent undiagnosed systemic vasculitis with only an ocular manifestation with Hodgkin's lymphoma, either as a coincidence or as a paraneoplastic syndrome.
  • Moreover, it emphasizes the important role of tissue biopsy in establishing diagnosis and directing treatment.
  • [MeSH-major] Eye Neoplasms / diagnosis. Hodgkin Disease / diagnosis. Scleritis / pathology
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis

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  • [Copyright] Copyright 2003 by the American Academy of Ophthalmology.
  • (PMID = 12750114.001).
  • [ISSN] 0161-6420
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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4. Lee WS, Chan TL, Koh MT, Ariffin WA, Lin HP: Acquired immunodeficiency syndrome presenting as childhood non-Hodgkin's lymphoma. Singapore Med J; 2001 Nov;42(11):530-3
HIV InSite. treatment guidelines - Ophthalmic Manifestations of HIV .

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  • [Title] Acquired immunodeficiency syndrome presenting as childhood non-Hodgkin's lymphoma.
  • Two children with non-Hodgkin's lymphoma (NHL) as the presenting illness of acquired immunodeficiency syndrome (AIDS) are described.
  • In the first case, an 18-month-old boy with stage IV, high-grade,T-cell NHL, the diagnosis of underlying AIDS was suspected only when he developed recurrent and profound opportunistic infection during chemotherapy.
  • She had progressive abdominal distension and swelling of her right eye one year later due to high grade B-cell NHL.
  • She was later found to be sero-positive for HIV during pre-chemotherapy screening.
  • [MeSH-major] Lymphoma, AIDS-Related / etiology. Lymphoma, B-Cell / etiology. Lymphoma, Non-Hodgkin / etiology. Lymphoma, T-Cell / etiology

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  • (PMID = 11876380.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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5. Mudhar HS, Fernando M, Sheard R, Rennie I: Paraneoplastic granulomatous vitritis and retinitis as a presentation of recurrent classical Hodgkin's lymphoma. Int Ophthalmol; 2010 Aug;30(4):341-3
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  • [Title] Paraneoplastic granulomatous vitritis and retinitis as a presentation of recurrent classical Hodgkin's lymphoma.
  • We describe a unique case of a patient with an established diagnosis of Hodgkin's lymphoma in clinical remission who later presented with apparent vitreous inflammation.
  • Since the latter can be a paraneoplastic phenomenon of active Hodgkin's lymphoma in distant organ sites, the haematologists were alerted to the possibility of recurrent lymphoma, despite the patient having no clinical symptoms.
  • Repeat body imaging showed enlarged mediastinal lymph nodes, biopsy of which confirmed recurrent Hodgkin's lymphoma.
  • The patient responded well to systemic chemotherapy with resolution of the visual symptoms.
  • This case report illustrates the importance of vitreous biopsy in this clinical setting and how to interpret the significance of granulomas in this context, and outlines a unique vitreo-retinal paraneoplastic granulomatous presentation in the setting of recurrent Hodgkin's lymphoma and how this diagnosis triggered a prompt review of the patient who had no constitutional symptoms, with hopefully a favourable impact on prognosis given the early recurrent disease detection.
  • [MeSH-major] Eye Diseases / etiology. Granuloma / etiology. Hodgkin Disease / complications. Paraneoplastic Syndromes / etiology. Retinitis / etiology. Vitreous Body
  • [MeSH-minor] Aged. Biopsy. Female. Humans. Inflammation / etiology. Inflammation / pathology. Lymph Nodes / pathology. Mediastinum. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 20076991.001).
  • [ISSN] 1573-2630
  • [Journal-full-title] International ophthalmology
  • [ISO-abbreviation] Int Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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6. Rattray KM, Cole MD, Smith SR: Systemic non-Hodgkin's lymphoma presenting as a serpiginous choroidopathy: report of a case and review of the literature. Eye (Lond); 2000 Oct;14 Pt 5:706-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Systemic non-Hodgkin's lymphoma presenting as a serpiginous choroidopathy: report of a case and review of the literature.
  • Intraocular lymphoma is a rare tumour, the two main types being primary central nervous system non-Hodgkin's lymphoma (CNS-NHL) and, less commonly, systemic lymphoma that has spread to involve the eye.
  • The diagnosis of this case was made based on the temporal relationship between the clinical activity of the choroidopathy and its response to chemotherapy.
  • Diagnosis of intraocular lymphoma on vitreous biopsy is notoriously difficult, and this case is presented along with a review of the literature regarding vitreous biopsy and diagnostic techniques.
  • [MeSH-major] Choroid Neoplasms / diagnosis. Lymphoma, B-Cell / diagnosis. Lymphoma, Follicular / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Fluorescein Angiography. Humans

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  • (PMID = 11116689.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 21
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7. Siepmann K, Rohrbach JM, Duncker G, Zierhut M: [Intraocular non-Hodgkin's lymphoma and its therapy-- a case series of ten patients]. Klin Monbl Augenheilkd; 2004 Apr;221(4):266-72
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  • [Title] [Intraocular non-Hodgkin's lymphoma and its therapy-- a case series of ten patients].
  • [Transliterated title] Das intraokulare Non-Hodgkin-Lymphom und seine Therapie -- eine Fallserie mit 10 Patienten.
  • BACKGROUND: The timely and correct diagnosis of intraocular non-Hodgkin's lymphoma represents a huge challenge to clinicians.
  • Two thirds of intraocular lymphomas are a manifestation of a primary CNS lymphoma (PCNSL) arising outside the lymphatic system and are localized in the brain, the meninges or the spinal chord.
  • Six patients had a concomitant CNS lesion while four patients showed isolated intraocular lymphoma only.
  • The presence of a highly malignant B cell lymphoma was proven by vitreous biopsy in nine cases and by stereotactic biopsy of a CNS lesion in one patient.
  • All patients were treated by intravenous chemotherapy, however, no binding recommendations with regard to treatment exist to date.
  • CONCLUSIONS: We give an overview of all current treatment regimens and their pitfalls.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Eye Neoplasms / drug therapy. Eye Neoplasms / pathology. Lymphoma, Non-Hodgkin / drug therapy. Lymphoma, Non-Hodgkin / pathology. Uveitis / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Humans. Lymphatic Metastasis. Male. Middle Aged. Treatment Outcome

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  • (PMID = 15118956.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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8. Ríhová E, Sisková A, Jandusová J, Kovarík Z, Sach J, Adam P: [Intraocular lymphoma--a clinical study of 14 patients with non-Hodgkin's lymphoma]. Cesk Slov Oftalmol; 2004 Jan;60(1):3-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intraocular lymphoma--a clinical study of 14 patients with non-Hodgkin's lymphoma].
  • AIM: To evaluate the course of clinical picture of intraocular lymphoma, possibilities of examination of this disease and the association with general symptoms of the non-Hodgkin lymphoma (NHL) in patients with manifestations of uveitis.
  • PATIENTS AND METHODS: A retrospective study in 14 patients followed in the period of 1996-2001 in the Center for Diagnostics and Therapy of Uveitis, Ocular Clinic of General Faculty Hospital and 1st Medical Faculty, Charles University in Prague.
  • The time period from the first symptoms to the diagnosis of NHL was 5-38 months (mean, 14.6 month).
  • In two patients the diagnosis of systemic NHL preceded ocular symptoms, in four other patients the diagnosis of systemic or central nervous system NHL (CNS NHL) was established during ocular manifestations of uveitis.
  • Intraocular lymphoma was the only first manifestation of CNS NHL in six patients for the period of 9-34 months (mean, 15.2).
  • Two patients have been so far affected by primary intraocular lymphoma (PIL) for 8 and 14 months respectively, and presently do not display any signs of systemic or CNS NHL.
  • Nine patients were treated with chemotherapy.
  • 50% of patients died until the end of 2001, the survival from the establishment of diagnosis was 20.6 months on the average.
  • CONCLUSIONS: Intraocular lymphoma should be considered as the eye and life-threatening disease.
  • Cytological examination of intraocular fluids in patients with uveitis who do not respond to the therapy with steroids in the usual way may give more precision and shorten the establishment of diagnosis in this masquerade syndrome.
  • Early diagnosis and therapy may improve the prognosis of NHL.
  • [MeSH-major] Eye Neoplasms / diagnosis. Lymphoma, Non-Hodgkin / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Retrospective Studies. Uveitis / diagnosis. Uveitis / etiology

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  • (PMID = 15011301.001).
  • [ISSN] 1211-9059
  • [Journal-full-title] Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti
  • [ISO-abbreviation] Cesk Slov Oftalmol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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9. Claeys A, Trullemans F, Maes J, Hennekes R, Salu P: Diplopia as an initial manifestation of disseminated non-hodgkin's lymphoma. Bull Soc Belge Ophtalmol; 2002;(286):35-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diplopia as an initial manifestation of disseminated non-hodgkin's lymphoma.
  • Ocular examination showed a partial paresis of the left eye (LE) on the left gaze, progressing in a few days towards a total ophthalmoplegia.
  • Further investigation revealed an intra-orbital mass, immunohistologically diagnosed as a Diffuse Large B-cell Lymphoma (DLBCL), according to the WHO classification.
  • Since the patient was in an advanced, disseminated stage of the disease (IVA-E), treatment was based on systemic and intrathecal chemotherapy with a pancranial radiotherapy.
  • We wish to stress that the possibility of orbital malignancy in young adults with acute onset of ophthalmoplegia should be included in the differential diagnosis.
  • [MeSH-major] Diplopia / etiology. Lymphoma, B-Cell / complications. Lymphoma, B-Cell / diagnosis. Optic Nerve Diseases / radiography. Orbital Neoplasms / radiography
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Bronchi / pathology. Bronchoscopy. Fatal Outcome. Humans. Lung / radiography. Male. Pancreatic Neoplasms / pathology. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 12564315.001).
  • [ISSN] 0081-0746
  • [Journal-full-title] Bulletin de la Société belge d'ophtalmologie
  • [ISO-abbreviation] Bull Soc Belge Ophtalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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10. Lim K, Ilsen PF: Optic disk edema in a patient with non-Hodgkin's lymphoma: is there a metastasis to the brain? Optometry; 2001 Jan;72(1):25-35
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  • [Title] Optic disk edema in a patient with non-Hodgkin's lymphoma: is there a metastasis to the brain?
  • This case report will present the manifestations and treatment of non-Hodgkin's lymphoma and review the differential diagnoses of bilateral disk edema.
  • CASE REPORT: A 51-year-old black man manifested symptoms of dizziness and intermittent loss of vision in the left eye for one week.
  • The patient did not return until about 10 weeks later, at which time he presented with a history significant for newly-diagnosed intermediate-grade non-Hodgkin's lymphoma.
  • He had begun chemotherapy one month before the second examination at our clinic; methotrexate therapy for CNS metastasis had been provided at the time of the spinal taps.
  • The patient's disk swelling resolved completely by the end of his six months of chemotherapy.
  • Bilateral disk edema in a patient with a history of non-Hodgkin's lymphoma is strongly suggestive of a metastatic tumor to the brain causing increased intracranial pressure.
  • [MeSH-major] Brain Neoplasms / secondary. Lymphoma, Non-Hodgkin / complications. Papilledema / etiology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 11217003.001).
  • [ISSN] 1529-1839
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Baehring JM, Hochberg FH: Primary lymphoma of the nervous system. Cancer J; 2006 Jan-Feb;12(1):1-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary lymphoma of the nervous system.
  • This review article provides guidelines for the diagnosis, staging, and management of primary nervous system lymphoma based on the results of clinical trials conducted during the last decade.
  • Recent progress in our understanding of the pathogenesis of primary nervous system lymphoma is summarized, and implications of these findings for the development of diagnostic tools and new therapeutic strategies are outlined.
  • We performed a search of the PubMed database (National Center for Biotechnology Information) for articles on primary nervous system lymphoma published between 1970 and May 2005.
  • Primary nervous system lymphoma affects the brain, eye, and meninges as well as cranial, spinal, and peripheral nerves.
  • Although important lessons have been learned from the pathogenesis of extraneural non-Hodgkin's lymphoma, the unique organotropism of primary nervous system lymphoma remains poorly understood.
  • Diagnosis is facilitated by modern imaging techniques and molecular markers.
  • Clinically recognizable "precursors" may exist but frequently elude specific diagnosis.
  • Insight into the peculiar pharmacokinetics of chemotherapy aimed at tumors within the nervous system has led to the development of methotrexate-based regimens that can achieve prolonged progression-free survival without the use of radiation.
  • Long-term survival and, in selected cases, even a cure are possible in primary nervous system lymphoma.
  • Treatment should be provided in specialized multidisciplinary centers.
  • In spite of remarkable progress through methotrexate-based chemotherapy, the majority of patients experience relapse within a few years.
  • Better diagnostic tools are required for earlier diagnosis and monitoring of treatment response.
  • A deeper understanding of the pathogenesis of primary nervous system lymphoma may reveal new therapeutic targets.
  • [MeSH-major] Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Nervous System Neoplasms / diagnosis. Nervous System Neoplasms / therapy
  • [MeSH-minor] Antimetabolites, Antineoplastic / therapeutic use. Combined Modality Therapy. Eye Neoplasms / therapy. Humans. Lymphoma, AIDS-Related / therapy. Magnetic Resonance Imaging. Methotrexate / therapeutic use. Organ Transplantation. Radiotherapy

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  • (PMID = 16613654.001).
  • [ISSN] 1528-9117
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; YL5FZ2Y5U1 / Methotrexate
  • [Number-of-references] 108
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12. Kim SK, Chan CC, Wallace DJ: Management of primary intraocular lymphoma. Curr Oncol Rep; 2005 Jan;7(1):74-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of primary intraocular lymphoma.
  • Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma (PCNSL) in which malignant lymphoid cells invade the retina, vitreous body, or optic nerve head.
  • It is usually a large B-cell non-Hodgkin's lymphoma.
  • PIOL typically presents as a vitritis that is unresponsive to corticosteroid therapy.
  • Diagnosis of PIOL requires pathologic confirmation of malignant cells in specimens of the cerebrospinal fluid, vitreous, or chorioretinal biopsies.
  • The optimal therapy for PIOL has yet to be determined.
  • It is generally believed that PIOL should be treated with a combination of systemic chemotherapy, including high-dose methotrexate and radiotherapy.
  • However, several new developments for PIOL with central nervous system involvement have been reported, including intrathecal therapy and autologous stem-cell transplantation.
  • In addition, intravitreal methotrexate has been successful in the treatment of isolated recurrent ocular disease.
  • This article provides an overview of treatment modalities for initial, recurrent, and relapsed PIOL.
  • [MeSH-major] Eye Neoplasms / diagnosis. Eye Neoplasms / therapy. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Medical Oncology / methods
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Clinical Trials as Topic. Combined Modality Therapy / methods. Humans. Methotrexate / therapeutic use. Radiotherapy / methods. Recurrence. Retina / pathology. Stem Cell Transplantation. Treatment Outcome

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  • (PMID = 15610690.001).
  • [ISSN] 1534-6269
  • [Journal-full-title] Current oncology reports
  • [ISO-abbreviation] Curr Oncol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; YL5FZ2Y5U1 / Methotrexate
  • [Number-of-references] 51
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13. Benzina Z, Khlif H, Sellami D, Sayadi I, Abdelmoula S, Trigui A, Kammoun B, Daoud J, Féki J: [Child orbital lymphoma: about one case]. Tunis Med; 2004 Sep;82(9):884-8
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  • [Title] [Child orbital lymphoma: about one case].
  • BACKGROUND: The non-Hodgkin's lymphomas are a group of neoplasms characterized by proliferation of malignant lymphocytes.
  • CASE REPORT: A 9-year old girl consulted for exophthalmia of the left eye without neither inflammation nor visual function alteration.
  • The biopsy done on a frontal metastasis affirmed the diagnosis of non-Hodgkin's lymphoma.
  • Chemotherapy led to tumour regression and involution of the exophthalmia.
  • The aim of this study is to evaluate the clinical features and treatment of child orbital lymphoma.
  • [MeSH-major] Lymphoma, B-Cell. Orbital Neoplasms
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Child. Exophthalmos / etiology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Orbit / pathology. Time Factors

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  • (PMID = 15693484.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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14. Pache M, Kain H, Buess M, Flammer J, Meyer P: [Primary intraocular lymphoma with unusual clinical presentation and poor outcome]. Klin Monbl Augenheilkd; 2004 May;221(5):401-3
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  • [Title] [Primary intraocular lymphoma with unusual clinical presentation and poor outcome].
  • [Transliterated title] Primäres intraokuläres Lymphom mit untypischer Klinik und ungünstigem Verlauf.
  • BACKGROUND: Primary intraocular lymphoma is a distinct subset of primary non-Hodgkin's lymphoma of the CNS.
  • In general, the primary non-Hodgkin's lymphoma of the CNS is rare, accounting for 1 % of all non-Hodgkin's lymphomas and less than 1 % of all intraocular tumors.
  • HISTORY AND SIGNS: A 70-year-old man was hospitalized in June 2002 because of acute loss of vision on his left eye.
  • An intraocular malignant B-cell lymphoma was determined by immunohistochemistry.
  • General screening revealed no further manifestations of the lymphoma.
  • THERAPY AND OUTCOME: The patient initially refused any therapy until a painful secondary neovascular glaucoma with complete loss of visual function developed, thus prompting us to perform an enucleation.
  • The following immunohistochemical examination confirmed the initial diagnosis.
  • A chemotherapy with high-dose methotrexate and leucovorin rescue was initiated.
  • CONCLUSIONS: Primary intraocular lymphoma can present as diffuse uveitis refractory to corticosteroids.
  • Diagnosis can be difficult and is often delayed.
  • [MeSH-major] Blindness / etiology. Lymphoma, B-Cell / diagnosis. Retinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Bruch Membrane / pathology. Chemotherapy, Adjuvant. Choroid / pathology. Choroid Neoplasms / diagnosis. Choroid Neoplasms / drug therapy. Choroid Neoplasms / pathology. Choroid Neoplasms / surgery. Combined Modality Therapy. Drug Resistance, Neoplasm. Eye Enucleation. Follow-Up Studies. Humans. Leucovorin / administration & dosage. Male. Methotrexate / administration & dosage. Optic Atrophy / pathology. Prognosis. Retina / pathology. Vitrectomy. Vitreous Body / pathology. Vitreous Hemorrhage / diagnosis. Vitreous Hemorrhage / pathology. Vitreous Hemorrhage / surgery

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  • (PMID = 15162291.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; YL5FZ2Y5U1 / Methotrexate
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15. Soldevilla HF, Molina RM, Navarra SV: Breast lymphoma in Sjögren's syndrome complicated by acute monocular blindness. Int J Rheum Dis; 2010 May;13(2):164-70
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  • [Title] Breast lymphoma in Sjögren's syndrome complicated by acute monocular blindness.
  • A 69-year-old hypertensive woman presented with eye and mouth dryness, bilateral parotid gland enlargement, associated with anasarca and proteinuria.
  • She underwent modified radical mastectomy of the right breast, and pathologic report revealed diffuse, small cell, non-Hodgkin's lymphoma of the breast; axillary lymph nodes were negative for tumor.
  • She opted for alternative therapy and did not return to the clinic until 7 months later when she developed sudden monocular blindness in the right eye with no other systemic manifestations.
  • She received pulse methylprednisolone therapy (1 g/day for 3 days) with partial recovery of vision.
  • She is scheduled for lymphoma chemotherapy to include rituximab.
  • [MeSH-major] Blindness / complications. Breast Neoplasms / complications. Lymphoma / complications. Sjogren's Syndrome / complications. Teaching Rounds
  • [MeSH-minor] Aged. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Mastectomy, Radical. Methylprednisolone / therapeutic use. Neoplasm Metastasis / diagnosis. Neuromyelitis Optica / diagnosis. Prednisone / therapeutic use. Radiography, Thoracic

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  • (PMID = 20536602.001).
  • [ISSN] 1756-185X
  • [Journal-full-title] International journal of rheumatic diseases
  • [ISO-abbreviation] Int J Rheum Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] VB0R961HZT / Prednisone; X4W7ZR7023 / Methylprednisolone
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16. Hoffman PM, McKelvie P, Hall AJ, Stawell RJ, Santamaria JD: Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes. Eye (Lond); 2003 May;17(4):513-21
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  • [Title] Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes.
  • AIMS: To assess the clinical features, pathology, mortality (systemic outcome) and ocular complications (visual outcome) of a cohort of patients treated for intraocular lymphoma.
  • METHODS: Retrospective case analysis of medical records and review of pathology of a consecutive series of patients presenting with intraocular lymphoma in Melbourne over 11 years between 1990 and 2000.
  • Most were male (64%) and had bilateral eye involvement (64%).
  • The commonest presentation was vitritis in 12 patients, with a median delay of 4 months before diagnosis.
  • In all, 10 patients had B-cell lymphoma, three patients T-cell lymphoma and one null-cell.
  • Four patients had prior systemic lymphoma.
  • Eight patients had primary central nervous system non-Hodgkin's lymphoma (PCNSL).
  • Treatment included combined radiation to the eye and chemotherapy in 10 patients.
  • A total of 11 patients died of lymphoma (79%).
  • Although currently disease free, one of these has a poor visual outcome with acuity less than 6/60 secondary to ocular complications of treatment.
  • CONCLUSIONS: Our study had 29% with prior systemic lymphoma, 57% associated with PCNSL and 14% with intraocular disease only.
  • [MeSH-major] Eye Neoplasms / pathology. Lymphoma, Non-Hodgkin / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Prognosis. Radiation Injuries / etiology. Radiotherapy / adverse effects. Recurrence. Retrospective Studies. Survival Analysis. Treatment Outcome. Vision Disorders / etiology

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  • (PMID = 12802353.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Kitzmann AS, Pulido JS, Garrity JA, Witzig TE: Histologic findings in T-cell lymphoma infiltration of the optic nerve. Ophthalmology; 2008 May;115(5):e1-6
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  • [Title] Histologic findings in T-cell lymphoma infiltration of the optic nerve.
  • OBJECTIVE: To report the clinical and histologic features of lymphomatous infiltration of the optic nerve by systemic T-cell non-Hodgkin's lymphoma (NHL).
  • METHODS: A 39-year-old man with a diagnosis of peripheral T-cell NHL, stage IV, with CNS involvement and decreased vision was found to have lymphomatous infiltration of the optic nerves.
  • RESULTS: Despite treatment with chemotherapy and an optic nerve sheath fenestration, the patient lost vision in the right eye and subsequently underwent an optic nerve biopsy.
  • The histopathology showed diffuse infiltration with a clonal population of lymphocytic cells that were CD3 positive and CD20 negative, consistent with T-cell NHL.
  • CONCLUSION: Optic nerve infiltration from systemic B-cell lymphoma is rare and has been reported; we report an unusual case of bilateral optic nerve infiltration secondary to peripheral T-cell NHL.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Lymphoma, T-Cell / pathology. Optic Nerve / pathology
  • [MeSH-minor] Adult. Antigens, CD20 / metabolism. Antigens, CD3 / metabolism. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging. Radiotherapy, Adjuvant. Visual Acuity

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  • (PMID = 18321583.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD3
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18. Nayak LM, Deschler DG: Lymphomas. Otolaryngol Clin North Am; 2003 Aug;36(4):625-46
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  • Hodgkin's and non-Hodgkin's lymphomas are an important part of the differential diagnosis of head and neck tumors.
  • Their diagnosis begins with a complete history and physical examination and is confirmed with an appropriately obtained and prepared pathologic specimen.
  • Prognosis and therapy of the lymphomas vary depending on stage and the characteristics of each particular subtype of lymphoma.
  • Low-grade lymphomas and chronic lymphocytic leukemia are characterized by long survival times and are most often treated with palliative intent.
  • Although chemotherapy and radiotherapy remain the mainstays of treatment, immunotherapy demonstrates increasing promise.
  • [MeSH-major] Head and Neck Neoplasms. Lymphoma
  • [MeSH-minor] Hodgkin Disease / pathology. Hodgkin Disease / therapy. Humans. Lymph Nodes / pathology. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Lymphoproliferative Disorders / diagnosis. Magnetic Resonance Imaging. Neoplasm Staging. Prognosis. Reed-Sternberg Cells / pathology. Tomography, X-Ray Computed

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  • (PMID = 14567057.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 86
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19. Lee JL, Kim MK, Lee KH, Hyun MS, Chung HS, Kim DS, Shin SO, Cho HS, Bae SH, Ryoo HM: Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue-type of the orbit and ocular adnexa. Ann Hematol; 2005 Jan;84(1):13-8
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  • [Title] Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue-type of the orbit and ocular adnexa.
  • Non-Hodgkin's lymphomas of the orbit and ocular adnexa (OOA), the majority of which are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue-type (MALT lymphomas), are a rare disorder.
  • The aim of this study was to evaluate the clinical features and treatment outcomes and complications in patients with MALT lymphoma of OOA.
  • Thirty-seven patients with a histologically verified diagnosis of MALT lymphoma of OOA were included in this retrospective, observational case study.
  • Surgical resection alone was attempted as the sole treatment in two patients, but tumor recurred 19 and 24 months after surgery.
  • Combination chemotherapy alone was employed in three patients with stage IIIA(E) or IVA(E).
  • Subgroup analysis of the patients with localized disease, who received radiotherapy as an initial treatment modality, revealed that 3-year OS rate and EFS rate were 100% and 93%, respectively.
  • All disease recurrences were documented histologically as MALT lymphoma.
  • In conclusion complete staging evaluation is needed to select an adequate treatment modality.
  • Radiotherapy alone can produce excellent local control and survival in patients with localized MALT lymphoma of OOA.
  • Systemic chemotherapy should be considered in patients with advanced stages or systemic manifestation.
  • [MeSH-major] Eye Neoplasms. Lymphoma, B-Cell, Marginal Zone
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Orbital Neoplasms / complications. Orbital Neoplasms / pathology. Orbital Neoplasms / therapy. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 15309523.001).
  • [ISSN] 0939-5555
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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20. Ng E, Ilsen PF: Orbital metastases. Optometry; 2010 Dec;81(12):647-57

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  • Radiotherapy and chemotherapy were initiated, but the patient died shortly afterward.
  • An area of the retina appeared elevated; ophthalmic B-scan and computed tomography of the orbits confirmed the presence of a mass, determined to be metastatic lung carcinoma to the right orbit.
  • A course of radiotherapy was initiated, but the patient died 3 days after completing therapy.
  • The last case was a 77-year-old white man with a history of metastasis to the left orbit from non-Hodgkin's lymphoma.
  • On examination, he had proptosis of the left eye, initially thought to be caused by a recurrence of the metastasis.
  • However, a computed tomography scan showed a new meningioma in the same orbit, and treatment was started.
  • Prognosis can be poor, and thus treatment is sometimes palliative in nature, intending to slow the progression of the disease instead of providing a cure.
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Adenocarcinoma / therapy. Aged. Blepharoptosis / etiology. Diplopia / etiology. Esophageal Neoplasms / pathology. Exophthalmos / etiology. Humans. Lung Neoplasms / pathology. Lymphoma, Non-Hodgkin / pathology. Magnetic Resonance Imaging. Male. Meningioma / pathology. Middle Aged. Neoplasms, Second Primary / pathology

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  • [Copyright] Copyright © 2010 American Optometric Association. All rights reserved.
  • (PMID = 21111373.001).
  • [ISSN] 1558-1527
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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