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1. Fox P: Anal cancer screening in men who have sex with men. Curr Opin HIV AIDS; 2009 Jan;4(1):64-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE OF REVIEW: To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men.
  • Two recent cohort studies have provided data that suggest that the precursor lesion (high-grade squamous intraepithelial lesion) might not be more prevalent in patients on highly active antiretroviral therapy than in historical pre-highly active antiretroviral therapy cohorts or in HIV-negative men who have sex with men.
  • If substantiated by further studies, this would make it easier to focus intervention with high-resolution anoscopy on a smaller group of patients.
  • This would be helpful because high-resolution anoscopy remains a resource that is both costly and difficult to access in most countries.
  • The sensitivity and specificity of anal cytology is poor and adjuncts to cytology such as p16(ink4a) staining and human papillomavirus viral loads might be utilized to further reduce the number of patients requiring high-resolution anoscopy.
  • Despite the burden of high-grade squamous intraepithelial lesion in HIV negative men who have sex with men, anal cancer remains uncommon in this group.
  • SUMMARY: Although routine anal cytology is not advisable for men who have sex with men at present, be they HIV positive or negative, clinicians should be regularly performing digital rectal examination in those at high risk of anal cancer, both to facilitate early detection of anal cancer and in the interests of health promotion.
  • [MeSH-minor] Anal Canal / pathology. Antiretroviral Therapy, Highly Active. Biomarkers, Tumor / analysis. Clinical Trials as Topic. Early Detection of Cancer. Epidemiologic Studies. HIV Infections / complications. HIV Infections / drug therapy. Humans. Male. Papillomavirus Infections / diagnosis. Papillomavirus Infections / etiology. Papillomavirus Infections / pathology. Proctoscopy. Sensitivity and Specificity. Viral Load

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  • (PMID = 19343830.001).
  • [ISSN] 1746-6318
  • [Journal-full-title] Current opinion in HIV and AIDS
  • [ISO-abbreviation] Curr Opin HIV AIDS
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 25
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2. Kiatpongsan S, Niruthisard S, Mutirangura A, Trivijitsilp P, Vasuratna A, Chaithongwongwatthana S, Lertkhachonsuk R: Role of human papillomavirus DNA testing in management of women with atypical squamous cells of undetermined significance. Int J Gynecol Cancer; 2006 Jan-Feb;16(1):262-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of human papillomavirus DNA testing in management of women with atypical squamous cells of undetermined significance.
  • To find the sensitivity, specificity, and positive and negative predictive values of the high-risk group human papillomavirus (HPV) DNA testing as a triage tool to detect high-grade squamous intraepithelial lesions (HSILs, ie, cervical intraepithelial neoplasia [CIN] 2 or worse) in women with a cytologic smear showing atypical squamous cells of undetermined significance (ASC-US).
  • All new cases with cytologic smears showing ASC-US that presented in King Chulalongkorn Memorial Hospital from January 2003 to November 2003, excluding known cases of HSILs and pregnancies, were enrolled.
  • Cervical cell samplings were done by cervical cytobrush technique and tested for high-risk group HPV with the Hybrid Capture 2 (HC2) test.
  • Of the 90 ASC-US cases enrolled, the pathologic results were normal in 30.0%, squamous metaplasia in 16.7%, CIN 1 in 37.8%, CIN 2 in 1.1%, CIN 3 in 11.1%, and microinvasive cervical carcinoma in 3.3%.
  • The prevalence of HSILs and the prevalence of high-risk HPV detection were 15.6% and 38.9%, respectively.
  • Using pathologic results from cervical biopsy as the gold standard, the HC2 has the sensitivity, specificity, and positive and negative predictive values of 85.7%, 69.7%, 34.3%, and 96.4%, respectively, to detect HSILs.
  • High-risk group HPV detection can be used as an additional triage test to detect HSILs in women having ASC-US with high sensitivity and negative predictive value.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Cervical Intraepithelial Neoplasia / virology. DNA, Viral / analysis. Papillomaviridae / isolation & purification. Uterine Cervical Neoplasms / virology
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Cohort Studies. DNA Probes, HPV. Female. Humans. Immunohistochemistry. Middle Aged. Papillomavirus Infections / diagnosis. Papillomavirus Infections / drug therapy. Risk Assessment. Sensitivity and Specificity. Thailand. Triage


3. Kirmizis D, Papagianni A, Dogrammatzi F, Skoura L, Belechri AM, Alexopoulos E, Efstratiadis G, Memmos D: Effects of simvastatin on markers of inflammation, oxidative stress and endothelial cell apoptosis in patients on chronic hemodialysis. J Atheroscler Thromb; 2010 Dec 26;17(12):1256-65
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  • METHODS: In 25 hyperlipidemic HD patients who received 10 mg of simvastatin for 6 months and another 25 controls, the extended lipid profile and serum hsIL-6, MCP-1, sICAM-1, sVCAM-1, and sE-selectin, plasma oxLDL, and serum sFas and sFasL levels were determined at baseline, 3 months and 6 months.
  • RESULT: Simvastatin treatment resulted in significant reductions in serum lipid levels at 3 months and beyond, compared to at baseline.
  • CONCLUSION: In conclusion, in hyperlipidemic HD patients, simvastatin treatment resulted in a significant reduction in markers of endothelial dysfunction, inflammation, oxidative stress, endothelial cell apoptosis and peripheral blood monocyte stimulation.
  • [MeSH-major] Kidney Failure, Chronic / drug therapy. Simvastatin / pharmacology
  • [MeSH-minor] Apoptosis / drug effects. Biomarkers / blood. C-Reactive Protein / analysis. Case-Control Studies. Endothelial Cells / drug effects. Humans. Hypolipidemic Agents / pharmacology. Inflammation / drug therapy. Lipids / blood. Monocytes / drug effects. Oxidative Stress / drug effects. Renal Dialysis

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  • (PMID = 20885069.001).
  • [ISSN] 1880-3873
  • [Journal-full-title] Journal of atherosclerosis and thrombosis
  • [ISO-abbreviation] J. Atheroscler. Thromb.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Hypolipidemic Agents; 0 / Lipids; 9007-41-4 / C-Reactive Protein; AGG2FN16EV / Simvastatin
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4. Zanoschi Ch, Anton C, Anton E, Costăchescu G, Teleman S, Costăchescu G, Ciupilan I, Cărăuleanu M, Cărăuleanu A, Leica V, Pânzaru C, Grigore M, Merticaru I, Huianu O, Huianu L, Chifan M: [Cervugid ovules in cervico-vaginal infections and cervix uteri precancerous conditions treatment]. Rev Med Chir Soc Med Nat Iasi; 2004 Jul-Sep;108(3):628-34
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  • [Title] [Cervugid ovules in cervico-vaginal infections and cervix uteri precancerous conditions treatment].
  • This medicine was authorized by the National Drug Agency (ANM, Bucureşti) in 2001.
  • RESULTS AND DISCUSSION: Healing of the subjective symptoms in 98%, healing of the leukorrhea--as a main objective symptom--in 95%; The Bethesda system cytotest was one of the inflammatory type in the most of the cases and there wew found in 85 cases: 6 ASCUS, 41 LSIL, and 37 HSIL.
  • Cervugid may be considered as an important agent in the treatment of the precancerous affections af the cervix uteri on the following reasons: zhe cure of the infections caused by chlamydia, involved in the etiology of cervical neoplasms, the cure of the HPV infection under episome form, classified in the Bethesda system within the ASCUS, AGUS or LSIL classes.
  • When the cytotest was in the HSIL class, a conization in the LLETZ method was performed.
  • In addition, it is active on chlamydia and mycoplasms, always sensitive to chloramphenicol therapy.
  • [MeSH-major] Anti-Infective Agents / therapeutic use. Anti-Inflammatory Agents / therapeutic use. Chloramphenicol / therapeutic use. Hydrocortisone / analogs & derivatives. Metronidazole / therapeutic use. Nystatin / therapeutic use. Precancerous Conditions / drug therapy. Uterine Cervical Dysplasia / drug therapy. Uterine Cervicitis / drug therapy. Vaginitis / drug therapy
  • [MeSH-minor] Administration, Intravaginal. Adolescent. Adult. Aged. Aged, 80 and over. Anti-Bacterial Agents / therapeutic use. Antifungal Agents / therapeutic use. Antiprotozoal Agents / therapeutic use. Drug Combinations. Female. Humans. Middle Aged. Papanicolaou Test. Treatment Outcome. Vaginal Smears

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  • (PMID = 15832988.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Infective Agents; 0 / Anti-Inflammatory Agents; 0 / Antifungal Agents; 0 / Antiprotozoal Agents; 0 / Cervugid; 0 / Drug Combinations; 1400-61-9 / Nystatin; 140QMO216E / Metronidazole; 3X7931PO74 / hydrocortisone acetate; 66974FR9Q1 / Chloramphenicol; WI4X0X7BPJ / Hydrocortisone
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5. Dursun P, Gultekin M, Bozdag G, Usubutun A, Uner A, Celik NY, Yuce K, Ayhan A: Primary cervical lymphoma: report of two cases and review of the literature. Gynecol Oncol; 2005 Sep;98(3):484-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this article, two cases of cervical lymphoma are presented with a review of the available literature.
  • Pap smear was reported as HSIL at another institution.
  • Radiological evaluation revealed a cervical mass with a 3 cm diameter.
  • We performed abdominal hysterectomy plus bilateral salphingo-oopherectomy and the patient was treated with adjuvant 6 cycles of CHOP chemotherapy.
  • Routine cytological smear revealed HSIL.
  • Due to discordance between cytology and histology, LEEP was performed under colposcopic examination, which revealed follicular lymphoma grade III.
  • This patient was treated with 6 cycles CHOP chemotherapy without any surgery.


6. Fox PA, Nathan M, Francis N, Singh N, Weir J, Dixon G, Barton SE, Bower M: A double-blind, randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high-grade anal intraepithelial neoplasia in HIV-positive MSM on HAART, with long-term follow-up data including the use of open-label imiquimod. AIDS; 2010 Sep 24;24(15):2331-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A double-blind, randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high-grade anal intraepithelial neoplasia in HIV-positive MSM on HAART, with long-term follow-up data including the use of open-label imiquimod.
  • OBJECTIVE: To determine whether imiquimod was more effective than placebo for the treatment of high-grade anal canal intraepithelial neoplasia (HG-ACIN).
  • METHODS: Sixty-four HIV-positive patients were randomized to self-application of imiquimod cream or matched placebo into the anal canal three times a week for 4 months.
  • Response was assessed by cytology, high-resolution anoscopy and biopsy 2 months after therapy.
  • All patients who failed to resolve were offered treatment with open-label imiquimod for a further 4 months.
  • RESULTS: Fifty-three patients completed the study, of which 28 patients were on active drug and 25 patients on placebo.
  • In the imiquimod group, four patients resolved and eight patients downgraded to low-grade squamous intraepithelial lesion (LSIL) with a median follow-up of 33 months.
  • Imiquimod was significantly associated with a positive outcome (P = 0.003).
  • Twenty-one patients entered a second open-label phase of treatment.
  • Five of these patients cleared their anal canal intraepithelial neoplasia (ACIN) and four patients downgraded to LSIL.
  • During this extended follow-up period, 61% have exhibited sustained absence of high-grade squamous intraepithelial lesion (HSIL).
  • CONCLUSION: This study demonstrates the effectiveness of imiquimod for the treatment of ACIN, and the benefit of prolonged or repeated treatments.
  • This form of therapy is likely to be especially valuable for patients with widespread multifocal ACIN who are otherwise difficult to treat, and should be considered as an adjunct to ablative therapy.
  • [MeSH-major] Aminoquinolines / administration & dosage. Anus Neoplasms / drug therapy. Carcinoma, Squamous Cell / drug therapy. HIV Infections / drug therapy. HIV-1 / drug effects
  • [MeSH-minor] Administration, Cutaneous. Adult. Antiretroviral Therapy, Highly Active. Double-Blind Method. Homosexuality, Male. Humans. Male


7. Katakura T, Kobayashi M, Herndon DN, Suzuki F: Effect of IL-12 and soluble IL-4 receptor on the herpesvirus infection in human SCID chimeras whose Th2 cells predominate. Immunol Cell Biol; 2004 Aug;82(4):421-6
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  • Th2 cytokines, commonly detected in burn patients, have been shown as inhibitors for the generation of Th1 cells that are essential for the host's resistance against herpes simplex virus type 1 (HSV-1) infection.
  • In this study, the possibility of immunological treatment through the regulation of Th1/Th2 responses was examined in two kinds of human severe combined immunodeficiency (SCID) chimera models reflecting human immune functions.
  • SCID mice injected with a mixture of PBMC from a healthy donor and Th2 cells experimentally generated from the same healthy PBMC (Th2 SCID chimeras) were more susceptible to HSV-1 infection when compared with SCID mice injected with healthy donor PBMC (healthy SCID chimeras).
  • When Th2 SCID chimeras were individually treated with human IL-12 (hIL-12) or human soluble IL-4 receptor (hsIL-4R), hIFN-gamma was not produced in their sera after antihuman CD3 mAb stimulation.
  • However, hIFN-gamma production in sera of Th2 SCID chimeras treated with the combination therapy of hIL-12 and hsIL-4R was recovered at levels observed in healthy SCID chimeras.
  • When Th2 SCID chimeras infected with HSV-1 were treated with saline, hIL-12, hsIL-4R or a combination of hIL-12 and hsIL-4R, 13%, 13%, 25% or 100% of them survived, respectively.
  • Also, Th1 responses (hIFN-gamma production) were demonstrated in Th2 SCID chimeras that became resistant against HSV-1 infection after the combination treatment.
  • These results suggest that individuals whose Th2 cells predominated may be immunologically controlled by the combination treatment between a Th1 response inducer and a Th2 response inhibitor.
  • [MeSH-major] Herpes Simplex / drug therapy. Herpes Simplex / immunology. Herpesvirus 1, Human. Interleukin-12 / therapeutic use. Receptors, Interleukin-4 / therapeutic use. Th2 Cells / immunology
  • [MeSH-minor] Animals. Burns / complications. Chimera. Disease Models, Animal. Drug Therapy, Combination. Humans. Interferon-gamma / blood. Male. Mice. Mice, SCID. Recombinant Proteins / therapeutic use

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  • (PMID = 15283853.001).
  • [ISSN] 0818-9641
  • [Journal-full-title] Immunology and cell biology
  • [ISO-abbreviation] Immunol. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Receptors, Interleukin-4; 0 / Recombinant Proteins; 187348-17-0 / Interleukin-12; 82115-62-6 / Interferon-gamma
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8. Ayas S, Karateke A, Aköz I, Kir G, Yenidede I: Primary serous carcinoma of the fallopian tube with synchronous cervical epidermoid carcinoma in situ: a case report. Eur J Gynaecol Oncol; 2007;28(6):501-2
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  • In this report we present a rare case of primary carcinoma of the fallopian tube with synchronous cervical high-grade squamous intraepithelial lesion (HSIL).
  • A 39-year-old women was admitted to our hospital for routine gynecological examination and underwent surgery because of the finding of HSIL on a routine papanicolaou smear.
  • The histological diagnosis on cervical biopsy and conization material were of cervical intraepithelial neoplasia III (CIN III).
  • Postoperatively the patient received six cycles of adjuvant chemotherapy (carboplatin and paclitaxel) and is still under routine control.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Fallopian Tube Neoplasms / diagnosis. Uterine Cervical Neoplasms / diagnosis


9. Fadare O, Parkash V, Carcangiu ML, Hui P: Epithelioid trophoblastic tumor: clinicopathological features with an emphasis on uterine cervical involvement. Mod Pathol; 2006 Jan;19(1):75-82
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  • All five tumors were invasive, nodular lesions consisting of epithelioid intermediate trophoblastic cells that were mononuclear with abundant eosinophilic cytoplasm, along with zones of hyaline material and necrotic debris.
  • In three cases of cervical involvement, the neoplastic cells focally replaced endocervical surface and glandular epithelium, simulating high-grade squamous intraepithelial lesions.
  • All patients received total hysterectomy and various regimes of adjuvant chemotherapy.
  • In summary, with its unusual ability to simulate an invasive squamous cell carcinoma and other epithelioid neoplasms, epithelioid trophoblastic tumor frequently poses a diagnostic challenge, especially when involving the uterine cervix.
  • High index of suspicion and an awareness of elevation of serum chorionic gonadotropin are crucial in reaching a correct diagnosis.

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  • (PMID = 16258513.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 9035-54-5 / Placental Lactogen
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10. Berkova Z, Kaufmann RH, Unger ER, Reeves WC, Adam E: The effect of time interval between referral and colposcopy on detection of human papillomavirus DNA and on outcome of biopsy. Am J Obstet Gynecol; 2003 Apr;188(4):932-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of time interval between referral and colposcopy on detection of human papillomavirus DNA and on outcome of biopsy.
  • OBJECTIVE: This study was undertaken to assess the effect of the time interval between referral cytology and the outcome of colposcopically directed biopsy in relation to human papillomavirus (HPV) DNA detected by polymerase chain reaction in women referred after abnormal Papanicolaou (Pap) smears.
  • STUDY DESIGN: The study enrolled 453 women who were referred for colposcopic examination after two Pap smears were reported as atypical squamous cells of undetermined significance (ASCUS) or low-grade intraepithelial lesions (LSIL) and 553 women who were referred with a single smear reported as high-grade squamous intraepithelial lesions (HSIL).
  • RESULTS: The results in both patient groups were evaluated in time intervals of 60 days or more, 61 to 120 days, and more than 120 days between referral and colposcopy.
  • Women of all race/ethnic backgrounds referred with HSIL were seen within 60 days in a significantly larger proportion than women referred with ASCUS/LSIL.
  • Women referred with ASCUS/LSIL had an increasing frequency of negative HPV findings with the prolonged time intervals.
  • In women referred with a single smear of HSIL, there was a significantly decreasing trend over time in detection of low-risk and unidentified types of HPV and an increasing trend of HPV DNA negative results.
  • CONCLUSION: The frequency of high-risk HPV DNA was similar in patients referred with ASCUS/LSIL or HSIL.
  • In both referral groups, there was a time-dependent increase of negative biopsy results and a decreased frequency of low-risk HPV or of unidentified HPV types.
  • This suggests that the initial abnormality on the Pap smear associated with other than high-risk HPV types may regress over time.
  • The presence of high-risk HPV DNA does not predict the actual histologically verifiable tissue changes but indicates a lower probability of negative biopsy results in all time intervals between referral and biopsy.
  • [MeSH-minor] Adult. Biopsy. Female. Humans. Papanicolaou Test. Time Factors. Vaginal Smears

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  • (PMID = 12712088.001).
  • [ISSN] 0002-9378
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / 200-92-0537
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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11. Oprica M, Van Dam AM, Lundkvist J, Iverfeldt K, Winblad B, Bartfai T, Schultzberg M: Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse. Acta Neuropathol; 2004 Jul;108(1):69-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The effects of chronic overexpression of human soluble IL-1ra (hsIL-1ra) were studied in a mouse model of permanent focal cerebral ischemia.
  • A transgenic mouse strain (Tg hsIL-1ra+/-) has been developed using the promoter for glial fibrillary acidic protein (GFAP) to limit the overexpression to the CNS.
  • Analysis of the neurological scores, infarct volume and edema formation revealed no differences between Tg hsIL-1ra+/- and wild-type (WT) mice.
  • The cerebral ischemia resulted in pronounced astrocyte proliferation and microglial activation, as well as induction of inflammatory markers in both Tg hsIL-1ra+/- and WT mice, with no major differences between the two genotypes.
  • Interestingly, hsIL-1ra expression in astrocytes was reduced in infarcted areas as compared to non-ischemic regions and sham-operated controls.
  • In conclusion, transgenic overexpression of hsIL1-ra was not neuroprotective in this cerebral ischemia model, possibly due to insufficient levels for protection against the extensive lesion, or an up-regulation of compensatory inflammatory signals due to the lifetime blockade of IL-1 receptors.
  • [MeSH-minor] Animals. Brain Edema / etiology. Brain Edema / genetics. Brain Edema / metabolism. Brain Edema / pathology. Brain Infarction / etiology. Brain Infarction / genetics. Brain Infarction / metabolism. Brain Infarction / pathology. Caspase 1 / metabolism. Disease Models, Animal. Fluorescent Antibody Technique / methods. Glial Fibrillary Acidic Protein / genetics. Glial Fibrillary Acidic Protein / metabolism. Infarction, Middle Cerebral Artery / complications. Infarction, Middle Cerebral Artery / drug therapy. Infarction, Middle Cerebral Artery / genetics. Interleukin 1 Receptor Antagonist Protein. Interleukin-1 / metabolism. Mice. Mice, Inbred C57BL. Mice, Transgenic. Neurologic Examination. Regional Blood Flow / physiology

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  • (PMID = 15138779.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / IL1RN protein, human; 0 / Il1rn protein, mouse; 0 / Interleukin 1 Receptor Antagonist Protein; 0 / Interleukin-1; 0 / Sialoglycoproteins; EC 3.4.22.36 / Caspase 1
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12. Trimble C, Lin CT, Hung CF, Pai S, Juang J, He L, Gillison M, Pardoll D, Wu L, Wu TC: Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe. Vaccine; 2003 Sep 8;21(25-26):4036-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We have previously linked Mycobacterium tuberculosis heat shock protein 70 (HSP70) to human papillomavirus type 16 (HPV-16) E7 in the context of a DNA vaccine.
  • The success of our strategy has led to two phases I/II clinical trial proposals in patients with HPV-16 associated high-grade squamous intraepithelial lesion (HSIL) of the cervix and in patients with advanced HPV-associated head and neck squamous cell carcinoma (HNSCC).
  • [MeSH-minor] Animals. Antibody Specificity. Biolistics. Cytokines / biosynthesis. Female. Flow Cytometry. HSP70 Heat-Shock Proteins / immunology. Injections, Intramuscular. Interferon-gamma / biosynthesis. Mice. Mice, Inbred C57BL. Papilloma / drug therapy. Papilloma / pathology. Papilloma / prevention & control. Papillomaviridae / immunology. Plasmids / genetics. Vaccines, DNA / administration & dosage. Vaccines, DNA / immunology

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  • (PMID = 12922140.001).
  • [ISSN] 0264-410X
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cancer Vaccines; 0 / Cytokines; 0 / HSP70 Heat-Shock Proteins; 0 / Vaccines, DNA; 82115-62-6 / Interferon-gamma
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13. Caprara L, Monari F, De Bianchi PS, Amadori A, Bondi A: [ASCUS in screening]. Pathologica; 2001 Dec;93(6):645-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The significance and use of the cytological diagnosis "atypical squamous cells of undetermined significance" (ASCUS) remain a major problem in cervical cancer screening.
  • The prevalence of diagnoses of low-grade squamous intraepithelial lesions (LG-SIL) decreased progressively with age while that of high-grade SIL was slightly higher between 30 and 39 years.
  • The observed peak reflects the prevalence of (1) cytological changes closely associated with perimenopausal age and at least compatible with the ASCUS diagnosis, and (2) cytological abnormalities induced by hormone replacement therapy.
  • [MeSH-minor] Adult. Aged. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Cervical Intraepithelial Neoplasia / diagnosis. Cervical Intraepithelial Neoplasia / pathology. Epithelial Cells / drug effects. Epithelial Cells / ultrastructure. Estrogens / pharmacology. False Positive Reactions. Female. Hormone Replacement Therapy. Humans. Italy. Menopause. Middle Aged. Neoplastic Stem Cells / ultrastructure. Progesterone / pharmacology. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / pathology


14. Buxant F, Bucella D, Anaf V, Simon P, Noël JC: Glucocorticoid receptor expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix. Eur J Gynaecol Oncol; 2009;30(3):259-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Glucocorticoid receptor expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix.
  • OBJECTIVES: Glucocorticoids (GCs) are used in cancer treatment to cause programmed cell death in transformed cells of the hematopoietic system and to lessen side-effects as nausea, vomiting, edema formation and allergies to specific chemotherapeutic agents.
  • Moreover, recently GCs were described as inhibitors of some chemotherapy or radiation-induced apoptosis.
  • METHODS: To clarify the issue, we tested by immunohistochemistry the expression status of GR in normal cervix epithelium (n = 30), in low-grade cervical intraepithelial neoplasia (LSIL) (n = 30), in high-grade cervical intraepithelial neoplasia (HSIL) (n = 30) and in invasive squamous cell carcinoma (ISCC) (n = 30).
  • All the patients with these lesions have a corresponding liquid-based cytology and were proved to be HPV-positive by using hybrid capture 2 methodology with probes against high-risk oncogenic HPvs. The evaluation of GR expression was performed by using the H-score system and an H-score > 50 was considered positive.
  • RESULT: GR expression was observed in normal epithelium, LSIL, HSIL and ISCC.
  • CONCLUSION: Because GCs could play a positive role in the progression of cancer, our demonstration of GR persistence in cervix cancer cells raises concern about the widespread combined use of GCs with antineoplastic drugs or agents in the clinical management of cervix cancer in women.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Cervical Intraepithelial Neoplasia / metabolism. Receptors, Glucocorticoid / metabolism. Uterine Cervical Neoplasms / metabolism


15. Feng W, Duan X, Liu J, Xiao J, Brown RE: Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions. Int J Clin Exp Pathol; 2009;2(3):249-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions.
  • Activation of Akt and mTOR are also observed in cervical squamous cell carcinoma and, the expression of phosphorylated mTOR was reported to serve as a marker to predict response to chemotherapy and survival of cervical cancer patients.
  • Therefore, we investigated: a) the expression level of EGFR in cervical squamous cell carcinoma (SCC) and high-grade squamous intraepithelial lesions (HSIL) versus non-neoplastic cervical squamous epithelium;.
  • b) the state of activation of the mTOR pathway in these same tissues; and c) any impact of these signal transduction molecules on cell cycle.
  • Formalin-fixed paraffin-embedded tissue microarray blocks containing 20 samples each of normal cervix, HSIL and invasive SCC, derived from a total of 60 cases of cervical biopsies and cervical conizations were examined.
  • We found that plasmalemmal EGFR expression was limited to the basal/parabasal cells (2-3+, EI = 67) in normal cervical epithelium (NL), but was diffusely positive in all HSIL (EI = 237) and SCC (EI 226).
  • The pattern of cytoplasmic p-mTOR and nuclear p-p70S6K expression was similar to that of EGFR; all showed a significantly increased EI in HSIL/SCC versus NL (p<0.02).
  • Nuclear translocation of p-mTOR was observed in all SCC lesions (EI = 202) and was significantly increased versus both HSIL (EI = 89) and NL (EI = 54) with p<0.015 and p<0.0001, respectively.
  • Concomitant increases in MI and proportion of nuclear Ki-67 and Skp2 expression were noted in HSIL and SCC.
  • In conclusion, morphoproteomic analysis reveals constitutive activation and overexpression of the mTOR pathway in HSIL and SCC as evidenced by: increased nuclear translocation of pmTOR and p-p70S6K, phosphorylated at putative sites of activation, Ser2448 and Thr389, respectively; correlative overexpression of the upstream signal transducer, EGFR, and increases in cell cycle correlates, Skp2 and mitotic indices.
  • These results suggest that the mTOR pathway plays a key role in cervical carcinogenesis and targeted therapies may be developed for SCC as well as its precursor lesion, HSIL.






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