[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 22 of about 22
1. Lee HL, Liu YY, Yeh CN, Chiang KC, Chen TC, Jan YY: Primary squamous cell carcinoma of the liver: a successful surgically treated case. World J Gastroenterol; 2006 Sep 7;12(33):5419-21
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary squamous cell carcinoma of the liver: a successful surgically treated case.
  • Primary squamous cell carcinoma (SCC) of the liver is rare.
  • Primary SCC of the liver has been reported to be associated with hepatic teratoma, hepatic cyst, or hepatolithiasis.
  • Complete remission of poorly differentiated SCC of the liver could be achieved by systemic chemotherapy followed by surgery or remarkably respond to hepatic arterial injection of low dose chemotherapeutic drugs.
  • Here we report the first case of primary SCC of the liver presenting as a solid tumor and receiving successful hepatic resection with 9-mo disease free survival.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery
  • [MeSH-minor] Adult. Disease-Free Survival. Humans. Liver / pathology. Liver / ultrasonography. Male. Remission Induction. Treatment Outcome. Ultrasonography

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Pathol Int. 2003 Feb;53(2):90-7 [12588436.001]
  • [Cites] Kurume Med J. 2003;50(1-2):71-5 [12971268.001]
  • [Cites] Eur J Gastroenterol Hepatol. 2004 Oct;16(10):1051-6 [15371931.001]
  • [Cites] Cancer. 1976 Nov;38(5):2002-5 [991114.001]
  • [Cites] Gut. 1990 Nov;31(11):1333-4 [2253922.001]
  • [Cites] Cell Prolif. 2005 Dec;38(6):407-21 [16300653.001]
  • [Cites] HPB Surg. 1992 Apr;5(3):203-8 [1510892.001]
  • [Cites] J Surg Oncol. 1994 Nov;57(3):210-2 [7967614.001]
  • [Cites] Acta Cytol. 1996 Mar-Apr;40(2):339-45 [8629424.001]
  • [Cites] Tumori. 2005 Jan-Feb;91(1):71-2 [15850008.001]
  • [Cites] Aust N Z J Surg. 1991 Sep;61(9):720-2 [1877947.001]
  • (PMID = 16981283.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4088220
  •  go-up   go-down


2. Eghtesad B, Marsh WJ, Cacciarelli T, Geller D, Reyes J, Jain A, Fontes P, Devera M, Fung J: Liver transplantation for growing teratoma syndrome: report of a case. Liver Transpl; 2003 Nov;9(11):1222-4
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver transplantation for growing teratoma syndrome: report of a case.
  • Liver transplantation is a well-established treatment for liver failure and for a selected group of patients with hepatic tumors.
  • The growing teratoma syndrome refers to the phenomenon whereby germ cell tumors enlarge after chemotherapy despite complete eradication of malignant cells and normalization of serum tumor markers.
  • We present the case of a young patient with rapidly growing teratomatous masses in his liver who was treated with liver transplantation from a live donor.
  • [MeSH-major] Liver Neoplasms / secondary. Liver Neoplasms / surgery. Liver Transplantation. Teratoma / pathology. Teratoma / surgery. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Neoplasm Invasiveness. Orchiectomy. Syndrome. Tomography, X-Ray Computed


3. Hartmann JT, Rick O, Oechsle K, Kuczyk M, Gauler T, Schöffski P, Schleicher J, Mayer F, Teichmann R, Kanz L, Bokemeyer C: Role of postchemotherapy surgery in the management of patients with liver metastases from germ cell tumors. Ann Surg; 2005 Aug;242(2):260-6
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of postchemotherapy surgery in the management of patients with liver metastases from germ cell tumors.
  • OBJECTIVE: To evaluate the role of postchemotherapy adjunctive surgery in patients with liver metastases from germ cell cancer (GCT).
  • PATIENTS AND METHODS: Forty-three male patients with nonseminoma were treated in different multicenter treatment protocols between 1990 and 1999, and they underwent hepatic surgery.
  • RESULTS: Thirty-five of 43 patients (81%) were initially diagnosed with liver metastases and advanced GCT, and 8 patients (19%) presented with metachronous liver metastases after a median interval of 16 months (range, 6-103 months).
  • Twelve patients (28%) had isolated liver metastases after completion of chemotherapy, while 31 patients (72%) had additional residual extrahepatic tumor masses.
  • Liver surgery included tumor excision or segmentectomy in 32 patients (74%) and hepatectomy (right/left) or resection of multiple segments in 11 patients (26%).
  • Histologic analysis of postchemotherapy resected residua yielded necrosis in 67%, teratoma in 12%, and viable cancer in 21%.
  • Additional resections at other sites have been performed in 31 patients revealing necrosis in 61% (n = 19), teratoma in 29% (n = 9), and vital carcinoma in 10% (n = 3).
  • In 39% of patients, histologic findings differed among liver and other resection sites.
  • Refractoriness to chemotherapy was associated with a shorter survival after surgery, and a trend was seen in patients with elevation of AFP.
  • CONCLUSION: The high rate of viable cancer and teratoma found in liver specimens, differing histologic results at residual tumor locations, and the high survival rate achieved support a multidisciplinary approach including resection of liver masses since no accurate selection of patients can narrow the use of surgery.
  • [MeSH-major] Germinoma / secondary. Germinoma / surgery. Liver Neoplasms / secondary. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Hepatectomy. Humans. Male. Middle Aged. Neoplasm, Residual / pathology. Teratoma / drug therapy. Teratoma / mortality. Teratoma / secondary. Teratoma / surgery. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Ann Surg Oncol. 1999 Oct-Nov;6(7):640-4 [10560848.001]
  • [Cites] N Engl J Med. 1997 Jul 24;337(4):242-53 [9227931.001]
  • [Cites] Cancer. 2001 Aug 1;92(3):578-87 [11505402.001]
  • [Cites] Ann Oncol. 2002 Jul;13(7):1017-28 [12176779.001]
  • [Cites] J Clin Oncol. 2003 Sep 1;21(17):3310-7 [12947067.001]
  • [Cites] J Clin Oncol. 2003 Nov 15;21(22):4083-91 [14568987.001]
  • [Cites] Ann Oncol. 2004 Sep;15(9):1377-99 [15319245.001]
  • [Cites] Ann Thorac Surg. 1983 Nov;36(5):524-8 [6195980.001]
  • [Cites] Br J Cancer. 1984 Nov;50(5):601-9 [6093838.001]
  • [Cites] Cancer. 1986 Mar 1;57(5):978-83 [3002596.001]
  • [Cites] Cancer. 1989 Feb 1;63(3):440-5 [2912523.001]
  • [Cites] J Clin Oncol. 1990 Oct;8(10):1683-94 [2170590.001]
  • [Cites] J Urol. 1991 Feb;145(2):300-2; discussion 302-3 [1988722.001]
  • [Cites] Cancer. 1994 Aug 15;74(4):1329-34 [8055456.001]
  • [Cites] Br J Cancer. 1994 Nov;70(5):960-5 [7524606.001]
  • [Cites] J Clin Oncol. 1995 May;13(5):1177-87 [7537801.001]
  • [Cites] J Clin Oncol. 1996 Jun;14(6):1765-9 [8656244.001]
  • [Cites] Ann Oncol. 1997 Jun;8(6):531-8 [9261521.001]
  • [Cites] Eur J Cancer. 1997 May;33(6):843-7 [9291803.001]
  • [Cites] Br J Urol. 1997 Oct;80(4):653-7 [9352708.001]
  • [Cites] J Clin Oncol. 1997 Feb;15(2):594-603 [9053482.001]
  • [Cites] J Clin Oncol. 2001 Jan 1;19(1):81-8 [11134198.001]
  • (PMID = 16041217.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1357732
  •  go-up   go-down


Advertisement
4. Moll A, Krenauer A, Bierbach U, Till H, Hirsch W, Leuschner I, Schmitz N, Wittekind C, Aigner T: Mixed hepatoblastoma and teratoma of the liver in a 3-year-old child: a unique combination and clinical challenge. Diagn Pathol; 2009;4:37

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed hepatoblastoma and teratoma of the liver in a 3-year-old child: a unique combination and clinical challenge.
  • Primary liver tumors in children are rare with malignant hepatoblastoma being the most common neoplasm.
  • In this report, we describe the diagnosis and clinical management of a large liver tumor in a 3-year-old child that displayed the features of both, conventional hepatoblastoma and malignant teratoma.
  • Histological and immunohistological examination of the resected tumor specimen additionally showed tumor areas of very different differentiation pattern intermixed with each other, namely areas of hepatoblastoma-typical and neuroblastoma-like morphology as well as areas of rhadomyosarcomatous differentiation.After chemotherapy the tumor size increased and an extended right hemihepatectomy was performed.
  • Post-operatively, the general condition of the child improved and adjuvant chemotherapy was started two weeks later.
  • 36 months after initial diagnosis the patient is healthy, in good general condition, and without any sign of residual tumor disease.Overall, we describe the diagnosis and clinical management of a large liver tumor in a 3-year-old child that displayed the features of both, conventional hepatoblastoma and malignant teratoma and was designated as mixed hepatoblastoma and teratoma.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Surg Oncol. 2007 Nov;16(3):195-203 [17714939.001]
  • [Cites] Diagn Pathol. 2009;4:17 [19523243.001]
  • [Cites] J Clin Oncol. 2000 Feb;18(4):832-9 [10673525.001]
  • [Cites] Histopathology. 2003 Sep;43(3):306-8 [12940789.001]
  • [Cites] Indian J Pathol Microbiol. 2003 Oct;46(4):658-9 [15025371.001]
  • [Cites] Pediatr Radiol. 2006 Mar;36(3):183-6 [16404556.001]
  • [Cites] J Clin Oncol. 1991 Dec;9(12):2167-76 [1720452.001]
  • [Cites] Cancer. 1993 Nov 15;72(10):2910-3 [8221556.001]
  • [Cites] J Clin Gastroenterol. 1993 Dec;17(4):308-10 [8308217.001]
  • [Cites] Eur J Surg Oncol. 2005 Dec;31(10):1160-5 [16157464.001]
  • [Cites] Cancer. 1986 Jun 1;57(11):2168-74 [2421866.001]
  • (PMID = 19909520.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2784753
  •  go-up   go-down


5. Gordon MS, Battiato LA, Finch D, Goulet R Jr, Einhorn LH: Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. Am J Clin Oncol; 2001 Jun;24(3):269-71
Hazardous Substances Data Bank. ALL-TRANS-RETINOIC ACID .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor.
  • A patient with nonseminomatous germ cell cancer, treated with standard chemotherapy, subsequently developed a pathologically confirmed metastatic undifferentiated adenocarcinoma (non-germ-cell elements) arising from residual teratoma.
  • Disease was present in both lobes of the liver and was deemed unresectable at the time of presentation.
  • After 60 days of oral therapy at a dose of 150 mg/m2/d (50 mg/m2 three times daily), the patient was found to have complete radiologic resolution of his hepatic metastases.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Germinoma / drug therapy. Neoplasms, Second Primary / drug therapy. Teratoma / drug therapy. Testicular Neoplasms / drug therapy. Tretinoin / therapeutic use


6. Yokoi Y, Suzuki S, Baba S, Ohzeki T, Yajima S, Okada S, Okumura T, Konno H, Nakamura S: Aggressive hepatectomy for complete remission of metastatic germ cell tumor following chemotherapy: report of a case. Hepatogastroenterology; 2003 Jul-Aug;50(52):1136-9
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive hepatectomy for complete remission of metastatic germ cell tumor following chemotherapy: report of a case.
  • A 12-year-old girl presented with hemoperitoneum caused by disseminated liver tumors accompanying a retroperitoneal germ cell tumor and was rescued by transcatheter hepatic arterial embolization.
  • Following systemic chemotherapy, the liver tumors decreased in size and number, although the retroperitoneal tumor was resistant to therapy.
  • We simultaneously resected the retroperitoneal tumor, and the liver lesions by extended left lobectomy combined with resection of the three major (right, middle, and left) hepatic veins, while preserving the inferior right hepatic vein.
  • The postoperative course was uneventful, and liver regeneration evaluated by serial computed tomography was almost completed by three months following surgery.
  • Pathological examination of the resected tumors revealed benign (mature) teratomas.
  • Since complete removal of tumors critically influences the outcome in patients with mature teratoma, aggressive surgery is advocated for extensive tumors.
  • The present case clearly demonstrated that extended hepatectomy with resection of three major hepatic veins is feasible and provides an opportunity for achieving complete remission in patients with metastatic germ cell tumor of the liver.
  • [MeSH-major] Germinoma / surgery. Hepatectomy. Liver Neoplasms / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Child. Embolization, Therapeutic. Female. Hemoperitoneum / etiology. Hemoperitoneum / therapy. Humans. Remission Induction

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12845998.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  •  go-up   go-down


7. Kobayashi N, Koizumi T, Eguchi T, Hyogotani A, Saito G, Hamanaka K, Shiina T, Kurai M, Kondo R, Yoshida K, Amano J: A mediastinal somatic-type germ cell tumor with hepatic metastasis successfully treated by multiple modalities. Anticancer Res; 2010 Dec;30(12):5117-20
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A mediastinal somatic-type germ cell tumor with hepatic metastasis successfully treated by multiple modalities.
  • Rhabdomyosarcoma in the mediastinum coexisting with metastatic non-seminomatous germ cell tumor, so-called somatic-type malignancy, is a rare carcinoma and has poor survival.
  • This study reports a case of diffuse and huge hepatic metastasis of non-seminomatous germ cell tumor associated with coexisting embryonal rhabdomyosarcoma in the mediastinum.
  • A 31-year-old man presented with abdominal pain and was found to have multiple abnormal hepatic masses on abdominal computed tomography (CT).
  • Chemotherapy was initiated because the hepatic lesion was diagnosed as choriocarcinoma, based on histological findings and the elevation of chorionic gonadotropin β-subunit and α-fetoprotein.
  • After six cycles of bleomycin, etoposide and cisplatin chemotherapy the metastatic liver tumors showed complete response.
  • The histological findings revealed mature teratoma with embryonal rhabdomyosarcoma.
  • The patient has remained well for over six years after the treatment without any signs of disease recurrence.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / drug therapy. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Mediastinal Neoplasms / drug therapy. Rhabdomyosarcoma, Embryonal / drug therapy. Teratoma / drug therapy

  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • Hazardous Substances Data Bank. BLEOMYCIN .
  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • Hazardous Substances Data Bank. ETOPOSIDE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21187499.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
  •  go-up   go-down


8. Liu H, Ye Z, Kim Y, Sharkis S, Jang YY: Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes. Hepatology; 2010 May;51(5):1810-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patient-specific iPS cells have been derived not only for disease modeling but also as sources for cell replacement therapy.
  • Here we show for the first time reprogramming of human endoderm-derived cells (i.e., primary hepatocytes) to pluripotency.
  • Hepatocyte-derived iPS cells appear indistinguishable from hES cells with respect to colony morphology, growth properties, expression of pluripotency-associated transcription factors and surface markers, and differentiation potential in embryoid body formation and teratoma assays.
  • In addition, these cells are able to directly differentiate into definitive endoderm, hepatic progenitors, and mature hepatocytes.
  • CONCLUSION: The technology to develop endoderm-derived human iPS cell lines, together with other established cell lines, will provide a foundation for elucidating the mechanisms of cellular reprogramming and for studying the safety and efficacy of differentially originated human iPS cells for cell therapy.
  • For the study of liver disease pathogenesis, this technology also provides a potentially more amenable system for generating liver disease-specific iPS cells.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Nature. 2009 Oct 1;461(7264):649-3 [19718018.001]
  • [Cites] Cell Res. 2009 Nov;19(11):1233-42 [19736565.001]
  • [Cites] Nat Biotechnol. 2009 Nov;27(11):1033-7 [19826408.001]
  • [Cites] Nat Genet. 2009 Dec;41(12):1350-3 [19881528.001]
  • [Cites] Cell Stem Cell. 2009 Dec 4;5(6):584-95 [19951687.001]
  • [Cites] Blood. 2009 Dec 24;114(27):5473-80 [19797525.001]
  • [Cites] Hepatology. 2010 Jan;51(1):329-35 [19877180.001]
  • [Cites] Nat Genet. 2002 Oct;32(2):312-5 [12355088.001]
  • [Cites] Cancer Res. 1993 Jun 15;53(12):2884-7 [8389246.001]
  • [Cites] Oncogene. 2006 Jun 26;25(27):3778-86 [16799619.001]
  • [Cites] Cell. 2006 Aug 25;126(4):663-76 [16904174.001]
  • [Cites] Cell. 2007 Nov 30;131(5):861-72 [18035408.001]
  • [Cites] Science. 2007 Dec 21;318(5858):1917-20 [18029452.001]
  • [Cites] Nature. 2008 Jan 10;451(7175):141-6 [18157115.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2883-8 [18287077.001]
  • [Cites] Stem Cells. 2008 May;26(5):1117-27 [18292207.001]
  • [Cites] Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):855-70 [18624675.001]
  • [Cites] Science. 2008 Aug 1;321(5889):699-702 [18276851.001]
  • [Cites] Nat Biotechnol. 2008 Aug;26(8):916-24 [18594521.001]
  • [Cites] Nat Biotechnol. 2008 Nov;26(11):1276-84 [18931654.001]
  • [Cites] Nature. 2009 Jan 8;457(7226):200-4 [19020503.001]
  • [Cites] Nat Biotechnol. 2009 Apr;27(4):353-60 [19330000.001]
  • [Cites] Cell Stem Cell. 2009 Jul 2;5(1):111-23 [19570518.001]
  • [Cites] Nat Biotechnol. 2009 Aug;27(8):743-5 [19590502.001]
  • [Cites] PLoS One. 2009;4(9):e7076 [19763270.001]
  • [Cites] Cancer. 2001 Jul 1;92(1):136-45 [11443619.001]
  • [CommentIn] Hepatology. 2010 Sep;52(3):1169; author reply 1169-70 [20812362.001]
  • (PMID = 20432258.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK070971-04; United States / NIDDK NIH HHS / DK / R01 DK070971; United States / NIDDK NIH HHS / DK / DK O70971; United States / NIDDK NIH HHS / DK / R01 DK070971-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HGF protein, human; 0 / activin A; 104625-48-1 / Activins; 62229-50-9 / Epidermal Growth Factor; 67256-21-7 / Hepatocyte Growth Factor
  • [Other-IDs] NLM/ NIHMS221023; NLM/ PMC2925460
  •  go-up   go-down


9. Cöl C: Immature teratoma in both mediastinum and liver of a 21-Year-old female patient. Acta Med Austriaca; 2003;30(1):26-8
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immature teratoma in both mediastinum and liver of a 21-Year-old female patient.
  • We present a case of an immature teratoma of the liver and the mediastinum.
  • Abdominal ultrasonography showed a liver tumor which is located in the right lobe and composed of cystic and solid elements.
  • Computed tomography (CT) also showed a big mass which contained multiple high density, nodular, semi-solid, heterogenic structures in the liver and another mass which contained multiple low density cystic lesions in the anterior mediastinum.
  • Right hepatic lobectomy was performed for liver tumour.
  • Intraoperative frozen sections of the liver tumor revealed teratoma.
  • But the final pathological diagnosis was immature teratoma.
  • Chemotherapy was given after surgery.
  • The patient tolerated the procedure well and her postoperative course was unremarkable.
  • At the first follow up 4 months after surgery she was alive and well and there was no evidence of recurrence, but the patient died within seven months with hepatic recurrence and spreading metastasis.
  • [MeSH-major] Liver Neoplasms / pathology. Liver Neoplasms / surgery. Teratoma / pathology. Teratoma / surgery
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Biopsy, Needle. Combined Modality Therapy. Female. Humans. Tomography, X-Ray Computed. Ultrasonography

  • Genetic Alliance. consumer health - Teratoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12558563.001).
  • [ISSN] 0303-8173
  • [Journal-full-title] Acta medica Austriaca
  • [ISO-abbreviation] Acta Med. Austriaca
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  •  go-up   go-down


10. Fan Q, Huang H, Lian L, Lang J: Characteristics, diagnosis and treatment of hepatic metastasis of pure immature ovarian teratoma. Chin Med J (Engl); 2001 May;114(5):506-9
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characteristics, diagnosis and treatment of hepatic metastasis of pure immature ovarian teratoma.
  • OBJECTIVE: To analyze the characteristics of hepatic metastasis of pure immature ovarian teratoma and explore its proper diagnosis and treatment.
  • METHODS: Eighteen cases of hepatic metastasis of pure immature ovarian teratoma were included in this study.
  • The clinical stage, operation, chemotherapy and histopathology of primary and secondary tumors as well as the data from long term follow-ups were analyzed retrospectively.
  • RESULTS: All of the hepatic metastatic tumors were located on the surface of the liver.
  • The hepatic metastatic rate was 16.7% (3/18) in the standard adjuvant chemotherapy group but increased markedly to 31.2% (15/48) in the irregular chemotherapy group.
  • The surgical resection rate of hepatic metastasis of pure immature ovarian teratoma was 94.4% (17/18).
  • The follow-up time ranged from 3 to 205 months with a mean of 20.9 months.
  • CONCLUSIONS: The hepatic metastatic rate of pure immature ovarian teratoma could be decreased using standard adjuvant chemotherapy.
  • Suitable surgical treatment could reduce complications and improve the prognosis for patients.
  • [MeSH-major] Liver Neoplasms / secondary. Ovarian Neoplasms / pathology. Teratoma / pathology

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11780414.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  •  go-up   go-down


11. Fan Q, Huang H, Lian L: [The characteristics diagnosis and treatment of hepatic metastasis of simple immature ovarian teratoma]. Zhonghua Fu Chan Ke Za Zhi; 2000 Oct;35(10):613-6
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The characteristics diagnosis and treatment of hepatic metastasis of simple immature ovarian teratoma].
  • OBJECTIVE: To analyze the characteristics of hepatic metastasis of pure immature ovarian teratoma and explore proper diagnosis and treatment.
  • METHODS: A total of 18 cases with hepatic metastasis of pure immature ovarian teratoma were involved in this study.
  • The clinical stage, operation, chemotherapy and histopathology of primary and secondary tumor as well as the data of long term follow-up were analyzed retrospectively.
  • RESULTS: All of the hepatic metastatic tumor located on the surface of liver, 66.1% (11/18) of them was clinically stage 3 and 44.4% (8/18) was grade 1 at first operation.
  • The hepatic metastatic rate was 16.7% (3/18) in standard adjuvant chemotherapy group but increased obviously to 31.2% (15/48) in irregular chemotherapy group.
  • The surgical resection rate of hepatic metastasis of pure immature ovarian teratoma was 94.4% (17/18).
  • The follow-up time ranged from 3-205 months with the mean of 20.9 months.
  • CONCLUSIONS: The hepatic metastatic rate of pure immature ovarian teratoma could be decreased by using standard adjuvant chemotherapy.
  • Suitable surgical treatment could reduce complication and improve the prognosis of this kind of patients.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Teratoma / diagnosis

  • Genetic Alliance. consumer health - Teratoma.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11372414.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


12. Howman-Giles R, Holland AJ, Mihm D, Montfort JM, Arbuckle S, Kellie S: Somatic malignant transformation in a sacrococcygeal teratoma in a child and the use of F18FDG PET imaging. Pediatr Surg Int; 2008 Apr;24(4):475-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Somatic malignant transformation in a sacrococcygeal teratoma in a child and the use of F18FDG PET imaging.
  • Biopsy revealed an adenocarcinoma most likely arising from a sacrococcygeal teratoma (SCT).
  • F(18)FDG Positron Emission Tomography (PET) scan confirmed marked metabolic activity in the tumour mass and regional lymph node involvement.
  • After chemotherapy repeat CT and PET studies revealed a poor response but no evidence of peritoneal or distant metastases.
  • Radical abdomino-pelvic and gluteal surgery was performed with removal of the entire tumour confirmed as a moderately differentiated adenocarcinoma arising in an immature teratoma.
  • Follow up imaging including PET scanning 5 months after her surgery revealed widespread peritoneal, hepatic and pulmonary metastases.
  • [MeSH-major] Adenocarcinoma. Fluorodeoxyglucose F18. Neoplasms, Multiple Primary. Positron-Emission Tomography. Radiopharmaceuticals. Teratoma
  • [MeSH-minor] Cell Transformation, Neoplastic / pathology. Child. Female. Humans. Sacrococcygeal Region. Treatment Outcome

  • Genetic Alliance. consumer health - Sacrococcygeal Teratoma.
  • Genetic Alliance. consumer health - Teratoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Br J Radiol. 2002 Jul;75(895):620-3 [12145137.001]
  • [Cites] J Pediatr Surg. 2004 Jul;39(7):1003-13 [15213888.001]
  • [Cites] Eur J Pediatr Surg. 1997 Jun;7(3):152-5 [9241501.001]
  • [Cites] J Pediatr Surg. 1992 Aug;27(8):1075-8; discussion 1078-9 [1403540.001]
  • [Cites] J Nucl Med. 2007 Jan;48 Suppl 1:78S-88S [17204723.001]
  • [Cites] J Pediatr Surg. 2006 Sep;41(9):1513-6 [16952583.001]
  • [Cites] Med Pediatr Oncol. 1998 Jul;31(1):8-15 [9607423.001]
  • [Cites] Ann Oncol. 2000 Mar;11(3):263-71 [10811491.001]
  • [Cites] J Pediatr Surg. 1992 Nov;27(11):1447-50 [1282543.001]
  • [Cites] Pediatr Surg Int. 2002 Sep;18(5-6):384-7 [12415361.001]
  • [Cites] J Clin Oncol. 1999 Apr;17(4):1212 [10561181.001]
  • [Cites] J Pediatr Surg. 1998 Feb;33(2):171-6 [9498381.001]
  • [Cites] J Urol. 1998 Mar;159(3):859-63 [9474169.001]
  • [Cites] J Urol. 1994 Oct;152(4):1144-9 [8072083.001]
  • [Cites] BMJ. 2004 Apr 24;328(7446):1002-6 [15105327.001]
  • [Cites] Cancer. 1995 Jun 1;75(11):2663-8 [7743467.001]
  • [Cites] J Urol. 1998 Jan;159(1):133-8 [9400455.001]
  • [Cites] J Clin Oncol. 1986 Oct;4(10):1493-9 [2428948.001]
  • [Cites] J Pediatr Surg. 1974 Jun;9(3):389-98 [4843993.001]
  • [Cites] J Clin Oncol. 1991 Oct;9(10):1782-92 [1717667.001]
  • [Cites] Cancer. 1985 Aug 15;56(4):860-3 [2990657.001]
  • [Cites] Int J Gynecol Pathol. 2002 Jul;21(3):261-7 [12068172.001]
  • [Cites] Pediatr Surg Int. 2003 Apr;19(1-2):47-51 [12721723.001]
  • [Cites] Cancer. 1992 Nov 15;70(10):2568-75 [1384951.001]
  • [Cites] Eur J Nucl Med Mol Imaging. 2005 Jan;32(1):23-30 [15290124.001]
  • (PMID = 17828545.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  •  go-up   go-down


13. You YN, Leibovitch BC, Que FG: Hepatic metastasectomy for testicular germ cell tumors: is it worth it? J Gastrointest Surg; 2009 Apr;13(4):595-601
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic metastasectomy for testicular germ cell tumors: is it worth it?
  • BACKGROUND: Chemotherapy is highly effective for metastatic germ cell tumor (GCT), but experience with resection of hepatic metastases from GCT is limited.
  • METHODS: Fifteen patients with GCT metastatic to the liver underwent 16 hepatic operations (1975-2002).
  • Pre-resection therapy, surgical pathology, and operative outcomes were reviewed.
  • Hepatic histology included: necrosis (33%), viable tumor (27%), mature teratoma (13%), and benign histology (27%).
  • Concomitant resection of extrahepatic disease (14 patients, 93%) found necrosis (53%), mature teratoma (27%), and viable tumor (13%).
  • The 10-year overall survival was 62% from diagnosis.
  • CONCLUSION: Resection of post-chemotherapy hepatic disease is safe, even when combined with resection of extrahepatic residual disease.
  • The varied histologic findings, lack of reliable predictors, and prolonged survival achieved support a multidisciplinary approach which includes surgical resection of hepatic metastases.
  • [MeSH-major] Hepatectomy. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / secondary

  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Ann Surg. 2005 Aug;242(2):260-6 [16041217.001]
  • [Cites] J Clin Oncol. 1997 Feb;15(2):594-603 [9053482.001]
  • [Cites] N Engl J Med. 1997 Jul 24;337(4):242-53 [9227931.001]
  • [Cites] J Urol. 2004 Jan;171(1):168-71 [14665869.001]
  • [Cites] J Urol. 2004 May;171(5):1835-8 [15076288.001]
  • [Cites] Ann Surg. 2008 Jan;247(1):125-35 [18156932.001]
  • [Cites] J Clin Oncol. 2006 Dec 10;24(35):5512-8 [17158536.001]
  • [Cites] Ann Thorac Surg. 1998 Nov;66(5):1709-14 [9875776.001]
  • [Cites] J Urol. 2006 Nov;176(5):1921-6 [17070212.001]
  • [Cites] J Clin Oncol. 2007 Dec 10;25(35):5603-8 [17998544.001]
  • [Cites] Cancer. 2003 Jan 1;97(1):63-70 [12491506.001]
  • [Cites] Cancer. 2001 Aug 1;92(3):578-87 [11505402.001]
  • [Cites] Curr Ther Endocrinol Metab. 1997;6:387-92 [9174777.001]
  • [Cites] J Clin Oncol. 2007 Mar 20;25(9):1033-7 [17261854.001]
  • [Cites] Ann Surg. 1990 Sep;212(3):290-3; discussion 293-4 [2168694.001]
  • [Cites] Urol Clin North Am. 2007 May;34(2):235-43; abstract x [17484928.001]
  • [Cites] Ann Surg Oncol. 2008 Jan;15(1):207-18 [17963007.001]
  • [Cites] J Pathol. 2007 Sep;213(1):65-71 [17634958.001]
  • [Cites] Ann Oncol. 2006 Sep;17 Suppl 10:x31-5 [17018745.001]
  • [Cites] Urol Clin North Am. 2007 May;34(2):199-217; abstract ix [17484925.001]
  • [Cites] Surgery. 2007 Jan;141(1):9-18 [17188163.001]
  • [Cites] Semin Urol Oncol. 2002 Nov;20(4):262-71 [12489059.001]
  • [Cites] Ann Surg Oncol. 1999 Oct-Nov;6(7):640-4 [10560848.001]
  • [Cites] Urol Clin North Am. 2007 May;34(2):187-97; abstract ix [17484924.001]
  • [Cites] Ann Oncol. 2004 Sep;15(9):1377-99 [15319245.001]
  • (PMID = 19190967.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


14. Tannuri AC, Tannuri U, Gibelli NE, Romão RL: Surgical treatment of hepatic tumors in children: lessons learned from liver transplantation. J Pediatr Surg; 2009 Nov;44(11):2083-7
MedlinePlus Health Information. consumer health - Liver Transplantation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of hepatic tumors in children: lessons learned from liver transplantation.
  • The objective of the present study was to describe our experience in liver resections, in the light of liver transplantation, emphasizing the indications for surgery, surgical techniques, complications, and results.
  • METHODS: The medical records of 53 children who underwent liver resection for primary or metastatic hepatic tumors were reviewed.
  • After neoadjuvant chemotherapy, tumor resectability was evaluated by another CT scan.
  • Surgery was performed by surgeons competent in liver transplantation.
  • As in liver living donor operation, vascular anomalies were investigated.
  • The main arterial anomalies found were the right hepatic artery emerging from the superior mesenteric artery and left hepatic artery from left gastric artery.
  • Hilar structures were dissected very close to liver parenchyma.
  • The hepatic artery and portal vein were dissected and ligated near their entrance to the liver parenchyma to avoid damaging the hilar vessels of the other lobe.
  • During dissection of the suprahepatic veins, the venous infusion was decreased to reduce central venous pressure and potential bleeding from hepatic veins and the vena cava.
  • RESULTS: Fifty-three children with hepatic tumors underwent surgical treatment, 47 patients underwent liver resections, and in 6 cases, liver transplantation was performed because the tumor was considered unresectable.
  • Ten children presented with other malignant tumors-3 undifferentiated sarcomas, 2 hepatocellular carcinomas, 2 fibrolamellar hepatocellular carcinomas, a rhabdomyosarcoma, an immature ovarian teratoma, and a single neuroblastoma.
  • Six children had benign tumors-4 mesenchymal hamartoma, 1 focal nodular hyperplasia, and a mucinous cystadenoma.
  • Hepatic resections included 22 right lobectomies, 9 right trisegmentectomies, 8 left lobectomies, 5 left trisegmentectomies, 2 left segmentectomies, and 1 case of monosegment (segment IV) resection.
  • CONCLUSION: The resection of hepatic tumors in children requires expertise in pediatric surgical practice, and many lessons learned from liver transplantation can be applied to hepatectomies.
  • [MeSH-major] Liver Neoplasms / surgery. Liver Transplantation / methods
  • [MeSH-minor] Age Factors. Blood Loss, Surgical. Carcinoma, Hepatocellular / mortality. Carcinoma, Hepatocellular / surgery. Follow-Up Studies. Hepatectomy / methods. Hepatoblastoma / mortality. Hepatoblastoma / surgery. Humans. Infant. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / surgery. Postoperative Complications / etiology. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

  • Genetic Alliance. consumer health - Transplantation.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19944212.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


15. Verma M, Agarwal S, Mohta A: Primary mixed germ cell tumour of the liver--a case report. Indian J Pathol Microbiol; 2003 Oct;46(4):658-9
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mixed germ cell tumour of the liver--a case report.
  • Germ cell tumours in liver are uncommon.
  • Primary mixed malignant germ cell tumours of liver are even rare.
  • Here we describe a case of primary mixed malignant germ cell tumour of left lobe of liver in a two and half year old male boy.
  • This is the first reported case of primary mixed malignant germ cell tumour with components of yolk sac tumour and mature teratoma in an infant.
  • Ultrasonography and computed tomography of the abdomen revealed a large hepatic mass.
  • Left lobectomy of liver was done and chemotherapy was initiated.
  • Histopathology of specimen disclosed yolk sac tumour and mature teratoma.
  • Widespread intrahepatic metastasis developed and patient died due to liver dysfunction after six months of left lobectomy.
  • [MeSH-major] Germinoma / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Child, Preschool. Endodermal Sinus Tumor / pathology. Humans. Male. Teratoma / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15025371.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  •  go-up   go-down


16. Beck SD, Foster RS, Bihrle R, Koch MO, Wahle GR, Donohue JP: Aortic replacement during post-chemotherapy retroperitoneal lymph node dissection. J Urol; 2001 May;165(5):1517-20
Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aortic replacement during post-chemotherapy retroperitoneal lymph node dissection.
  • PURPOSE: We reviewed the records of 15 patients with metastatic germ cell cancer who underwent aortic resection and replacement during post-chemotherapy retroperitoneal lymph node dissection to determine the morbidity and the therapeutic benefit.
  • MATERIALS AND METHODS: Between 1970 and 1998, 1,250 patients underwent post-chemotherapy retroperitoneal lymph node dissection.
  • RESULTS: In addition to aortic replacement 11 patients underwent 15 additional procedures, including nephrectomy in 7, vena caval resection in 3, pulmonary resection in 1, small bowel resection in 2, 1 hepatic resection in 1 and L4 vertebrectomy in 1.
  • Three patients (20%) had teratoma and 12 (80%) had viable tumor in the retroperitoneal specimen.
  • All 4 patients who underwent post-chemotherapy retroperitoneal lymph node dissection and aortic replacement after induction chemotherapy alone have no evidence of disease.
  • Only 1 of the 11 patients who received salvage chemotherapy with or without previous post-chemotherapy retroperitoneal lymph node dissection have no evidence of disease.
  • CONCLUSIONS: Aortic resection at post-chemotherapy retroperitoneal lymph node dissection is justified based on therapeutic benefit and morbidity.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Aorta, Abdominal / surgery. Blood Vessel Prosthesis Implantation. Germinoma / surgery. Lymph Node Excision. Testicular Neoplasms / pathology
  • [MeSH-minor] Cisplatin / administration & dosage. Humans. Lymphatic Metastasis. Male. Retroperitoneal Space. Retrospective Studies. Salvage Therapy

  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11342909.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
  •  go-up   go-down


17. Buccoliero AM, Castiglione F, Maio V, Moncini D, Sardi I, Taddei A, Martin A, Messineo A, Taddei GL: Teratoid hepatoblastoma. Fetal Pediatr Pathol; 2008;27(6):274-81
MedlinePlus Health Information. consumer health - Neuroblastoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present the case of a Middle Eastern child, diagnosed and treated at 8 months of age for a hepatic neuroblastoma.
  • After surgical removal of a 7 cm mass of the left liver lobe at our institution when the child was 15 months of age, the tumor was reclassified as a teratoid hepatoblastoma.
  • The tumor was composed of fetal and embryonal hepatic tissue, undifferentiated tissue, and a teratoid background of loose mesenchymal tissue containing osteoid, squamous, and mucinous epithelium.
  • We speculate on the histogenesis of teratoid hepatoblastoma and discuss its association with chemotherapy.
  • [MeSH-major] Hepatoblastoma / diagnosis. Liver Neoplasms / diagnosis. Neuroblastoma / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Humans. Infant. Male

  • Genetic Alliance. consumer health - Hepatoblastoma.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19065325.001).
  • [ISSN] 1551-3823
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


18. Kinoshita Y, Tajiri T, Souzaki R, Tatsuta K, Higashi M, Izaki T, Takahashi Y, Taguchi T: Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. J Pediatr Hematol Oncol; 2008 Jun;30(6):447-50
Faculty of 1000. commentaries/discussion - See the articles recommended by F1000Prime's Faculty of more than 8,000 leading experts in Biology and Medicine. (subscription/membership/fee required).

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study.
  • RESULTS: In all cases of hepatoblastoma and yolk sac tumor, both the total AFP and the L3 fraction were high, either before treatment or in the presence of malignant tumors.
  • Most of the cases of neonatal immature teratoma showed a high total AFP level during the neoinfantile period, however, the L3 fraction was around 10%, and decreased after surgical treatment.
  • Only 1 case of the immature teratoma demonstrated malignant transformation, when the patient was 8 months old.
  • As the total AFP and the AFP-L3 fraction were proportionally elevated, the patient was treated with additional surgical resection and chemotherapy.
  • In the case of neonatal mature teratoma, the L3 fraction was below 0.5%, even when the total AFP level was high.
  • DISCUSSION: Our results indicated that the level of the L3 fraction accurately confirmed the existence, or the malignant potential of hepatic tumor or germ cell tumor.
  • [MeSH-major] Biomarkers, Tumor / blood. Hepatoblastoma / blood. Liver Neoplasms / blood. Neoplasms, Germ Cell and Embryonal / blood. alpha-Fetoproteins / analysis

  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18525461.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Lectins; 0 / Protein Isoforms; 0 / alpha-Fetoproteins
  •  go-up   go-down


19. Minowada S, Okano Y, Miyazaki J, Homma Y, Kitamura T: Multidisciplinary treatment of advanced testicular tumor with bulky liver metastasis. Urol Int; 2001;67(2):178-80
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multidisciplinary treatment of advanced testicular tumor with bulky liver metastasis.
  • He had multiple bulky metastases in the liver and retroperitoneum with an extraordinarily elevated serum alpha-fetoprotein (23,500 ng/ml).
  • He received multidisciplinary treatment consisting of systemic chemotherapy, cytoreductive left hepatic lobectomy, percutaneous ablation therapy, transarterial chemoembolization, and external beam irradiation for median segments of the liver.
  • The efficient combination treatment normalized the tumor markers within 6 months and has maintained complete serological remission for 4.7 years.
  • [MeSH-major] Carcinoma, Embryonal / secondary. Endodermal Sinus Tumor / secondary. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Neoplasms, Multiple Primary / secondary. Teratoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Male. Neoplasm Staging

  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2001 S. Karger AG, Basel.
  • (PMID = 11490219.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


20. Albert A, Cruz O, Montaner A, Vela A, Badosa J, Castañón M, Morales L: [Congenital solid tumors. A thirteen-year review]. Cir Pediatr; 2004 Jul;17(3):133-6
MedlinePlus Health Information. consumer health - Wilms Tumor.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This is an interesting group of tumors because their type, relative incidence, natural history and response to treatment differ from those seen in older children.
  • There were 8 teratomas (3 sacrocoxigeal, 1 retroperitoneal, 1 in the CNS, 1 orbitary and two oronasal), two hepatic tumors (1 hepatoblastoma, 1 hemangioendothelioma, two CNS tumors, two giant nevus (one on a hamartoma), and one each Wilms tumor, infantile fibrosarcoma and myofibroblastic tumor.
  • Treatment was surgical resection alone in 17 cases (68%) and surgery + chemotherapy in 8 (32%) (5 neuroblastomas, one CNS tumor, one Wilms tumor and one presacral teratoma who developed a yolk sac tumor); 3 patients died (11%): one at surgery, one of tumoural airway obstruction at birth and one with craniopharyngioma.
  • Among the 14 tumors that were initially not malignant, two can be locally agressive, one was an immature teratoma, the giant nevus with hamartoma developed in situ melanoma, the other nevus had meningeal melanosis with hydrocephalus, and one mature presacral teratoma developed a yolk sac tumor.
  • CONCLUSIONS: Diagnosis of congenital tumors is performed earlier in recent years due to the wide use of prenatal ultrasound.
  • Their natural history is more benign than in other age groups, except for CNS tumors and very large or obstructing tumors.
  • Complete surgical excision is the treatment of choice, most cases not need adjuvant chemotherapy.
  • We ought to pass this message on to our colleagues in prenatal diagnosis, so parents get reliable information.
  • [MeSH-major] Central Nervous System Neoplasms / congenital. Kidney Neoplasms / congenital. Liver Neoplasms / congenital. Neuroblastoma / congenital. Skin Neoplasms / congenital. Soft Tissue Neoplasms / congenital. Teratoma / congenital. Wilms Tumor / congenital
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Infant, Newborn. Male. Neoplasm Recurrence, Local. Postoperative Complications. Pregnancy. Prenatal Diagnosis. Time Factors

  • MedlinePlus Health Information. consumer health - Kidney Cancer.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • MedlinePlus Health Information. consumer health - Neuroblastoma.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15503950.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


21. Rao S, Azmy A, Carachi R: Neonatal tumours: a single-centre experience. Pediatr Surg Int; 2002 Sep;18(5-6):306-9
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present our experience of managing neonatal tumours in a tertiary reference centre to study the incidence, pathology and types, efficacy of treatment, and impact of antenatal diagnosis on the management in our practice in a retrospective study of case-notes and pathology reports.
  • Teratomas were the commonest type (n = 33, 40%) followed by neuroblastomas (NB) (14), renal (13), soft-tissue (10), hepatic (4), and miscellaneous tumours (2).
  • Surgery remains the mainstay of treatment.
  • Chemotherapy has also become safer.
  • Therapeutic complications were responsible for 50% of deaths before 1986; from 1986 onwards, there has been no therapy-related mortality.
  • The small numbers of neonatal tumours seen by individual centres underline the need for an international effort to optimise therapy and improve understanding of these tumours.
  • [MeSH-minor] Female. Humans. Infant, Newborn. Kidney Neoplasms / surgery. Male. Neuroblastoma / surgery. Retrospective Studies. Soft Tissue Neoplasms / surgery. Teratoma / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12415344.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


22. Yamamoto H, Quinn G, Asari A, Yamanokuchi H, Teratani T, Terada M, Ochiya T: Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology; 2003 May;37(5):983-93
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application.
  • Embryonic stem (ES) cells provide a unique source for tissue regeneration.
  • After transplantation into the carbon tetrachloride-injured mouse liver, ES-derived green fluorescent protein-positive cells were incorporated into liver tissue and rescued mice from hepatic injury.
  • No teratoma formation was observed in the transplant recipients.
  • In conclusion, ES cells can provide a valuable tool for studying the molecular basis for differentiation of hepatocytes and form the basis for cell therapies.
  • [MeSH-major] Drug-Induced Liver Injury / therapy. Hepatocytes / cytology. Stem Cell Transplantation. Stem Cells / cytology
  • [MeSH-minor] Albumins / genetics. Animals. Carbon Tetrachloride. Cell Differentiation. Cells, Cultured. Female. Green Fluorescent Proteins. Immunohistochemistry. Indicators and Reagents / metabolism. Liver Regeneration. Luminescent Proteins / genetics. Male. Mice. Mice, Inbred Strains

  • MedlinePlus Health Information. consumer health - Drug Reactions.
  • MedlinePlus Health Information. consumer health - Stem Cells.
  • Hazardous Substances Data Bank. CARBON TETRACHLORIDE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12717379.001).
  • [ISSN] 0270-9139
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins; 0 / Indicators and Reagents; 0 / Luminescent Proteins; 147336-22-9 / Green Fluorescent Proteins; CL2T97X0V0 / Carbon Tetrachloride
  •  go-up   go-down






Advertisement