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1. Pertile D, Scabini S, Romairone E, Scordamaglia R, Rimini E, Ferrando V: Gastric Abrikosoff tumor (granular cell tumor): case report. G Chir; 2010 Oct;31(10):433-4
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  • [Title] Gastric Abrikosoff tumor (granular cell tumor): case report.
  • Granular Cells Tumor (GCT), also called Abrikosoff tumor, is very uncommon lesion of neural derivation.
  • It is characterized by the presence of granular cell; benign and malignamt counterparts are known, even if the second ones are rare.
  • Surgical en-block excision is curative for both benign an malignant forms.
  • Radiotherapy and chemotherapy are not effective.
  • We report the case of a 45 year old man who had a cytologic diagnosis of fusocellular stromal tumor of the gastric fundus during examination for gastritis.
  • He underwent a wedge resection of the gastric wall: at the histological examination neoplastic cells had a granular cytoplasm and immunoassay was positive for S100 protein, PGP 9.5 and NSE.
  • [MeSH-major] Granular Cell Tumor. Stomach Neoplasms

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  • (PMID = 20939949.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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2. Kinkor Z, Hes O: [Pleomorphic epithelioid/clear cell malignant tumor of the uterus exhibiting both myoid and melanocytic differentiation--leiomyosarcoma or PEComa? A case report and a review of the literature]. Cesk Patol; 2007 Jul;43(3):103-8
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  • [Title] [Pleomorphic epithelioid/clear cell malignant tumor of the uterus exhibiting both myoid and melanocytic differentiation--leiomyosarcoma or PEComa? A case report and a review of the literature].
  • [Transliterated title] Pleomorfni epiteloidni a svetlobunecný maligní tumor delohy s myoidní a melanocytární diferenciací--leiomyosarkom nebo PECom? Kazuistika a prehled literatury.
  • The neoplasm broadly invaded myometrium with no evidence of endometrial cavity involvement.
  • Microscopically, the tumor displayed solid mosaic pattern and consisted of large epithelioid cells with ample eosinophilic, finely granular cytoplasm ongoing apparent clear cell change elsewhere.
  • No obvious stigmata of tuberous sclerosis were found and a five months follow-up after chemotherapy indicated no progression of disease.
  • With some uncertainty the tumor was finally rendered as pleomorphic leiomyosarcoma with peculiar melanocytic differentiation.
  • Reviewed is the literature and discussed is the differential diagnosis.


3. Rocha LA, Rizo VH, Romañach MJ, de Almeida OP, Vargas PA: Oral metastasis of alveolar soft-part sarcoma: a case report and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Apr;109(4):587-93
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  • Alveolar soft-part sarcoma (ASPS) is a rare malignant neoplasm with uncertain histogenesis and with a distinctive morphology.
  • A 27-year-old male patient, who was under chemotherapy treatment for ASPS of the thigh, presented in our dental clinic with a painless and pedunculated nodule on the right tuber maxillae.
  • An incisional biopsy was performed and the diagnosis of metastatic ASPS was made.
  • Histologically, the tumor was characterized by a proliferation of polyhedral cells in pseudoalveolar pattern.
  • Tumor cells were large, showing granular cytoplasm, periodic acid-Schiff positive diastase-resistant intracytoplasmic material, and vesicular nuclei with prominent nucleoli.
  • Unfortunately, the patient died 2 months after the diagnosis of the oral metastasis.
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Cell Nucleolus / ultrastructure. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Diagnosis, Differential. Fatal Outcome. Gingival Diseases / diagnosis. Granuloma, Giant Cell / diagnosis. Granuloma, Pyogenic / diagnosis. Humans. Male. Muscle Neoplasms / pathology. Thigh / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20303057.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Shi Y, Morgenstern N: Granular cell astrocytoma. Arch Pathol Lab Med; 2008 Dec;132(12):1946-50
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  • [Title] Granular cell astrocytoma.
  • Granular cell astrocytoma (GCA) is a rare type of malignant brain tumor with distinct morphologic features and aggressive clinical behavior.
  • It is characterized by a prominent component of bland-looking granular cells.
  • The tumor cells are usually positive for glial fibrillary acidic protein, S100, CD68, and epithelial membrane antigen.
  • Loss of 9p and 10q were identified in almost all cases of GCA, but they are not specific for this tumor.
  • Surgical excision plus postoperative chemotherapy or radiotherapy is the choice for most patients with GCA.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Granular Cell Tumor / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Astrocytes / metabolism. Astrocytes / pathology. Diagnosis, Differential. Glial Fibrillary Acidic Protein / metabolism. Humans. Middle Aged. S100 Proteins / metabolism

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  • (PMID = 19061297.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins
  • [Number-of-references] 22
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5. Rodini CO, Suzuki DE, Nakahata AM, Pereira MC, Janjoppi L, Toledo SR, Okamoto OK: Aberrant signaling pathways in medulloblastomas: a stem cell connection. Arq Neuropsiquiatr; 2010 Dec;68(6):947-52
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  • [Title] Aberrant signaling pathways in medulloblastomas: a stem cell connection.
  • Medulloblastoma is a highly malignant primary tumor of the central nervous system.
  • It represents the most frequent type of solid tumor and the leading cause of death related to cancer in early childhood.
  • Current treatment includes surgery, chemotherapy and radiotherapy which may lead to severe cognitive impairment and secondary brain tumors.
  • New perspectives for therapeutic development have emerged with the identification of stem-like cells displaying high tumorigenic potential and increased radio- and chemo-resistance in gliomas.
  • Under the cancer stem cell hypothesis, transformation of neural stem cells and/or granular neuron progenitors of the cerebellum are though to be involved in medulloblastoma development.
  • From the clinical viewpoint, modulation of signaling pathways such as TGFβ, regulating neural stem cell proliferation and tumor development, might be attempted as an alternative strategy for future drug development aiming at more efficient therapies and improved clinical outcome of patients with pediatric brain cancers.

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  • (PMID = 21243257.001).
  • [ISSN] 1678-4227
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Transforming Growth Factor beta
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6. Chiang MJ, Fang TJ, Li HY, Chen IH, Lee KF: Malignant granular cell tumor in larynx mimicking laryngeal carcinoma. Am J Otolaryngol; 2004 Jul-Aug;25(4):270-3
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  • [Title] Malignant granular cell tumor in larynx mimicking laryngeal carcinoma.
  • Under the impression of malignant laryngeal tumor with lung metastasis, he underwent direct laryngeal biopsy and excision.
  • Pathologic findings showed malignant granular cell tumor.
  • Postoperative palliative chemotherapy was done for his lung metastasis.
  • The laryngeal tumor has not recurred after a 14-month follow-up.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Laryngeal Neoplasms / diagnosis. Lung Neoplasms / secondary
  • [MeSH-minor] Aged. Carcinoma / diagnosis. Chemotherapy, Adjuvant. Deglutition Disorders / etiology. Diagnosis, Differential. Dyspnea / etiology. Humans. Immunohistochemistry. Laryngoscopy. Male. Palliative Care

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  • (PMID = 15239036.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. VanDeusen JB, Caligiuri MA: New developments in anti-tumor efficacy and malignant transformation of human natural killer cells. Curr Opin Hematol; 2003 Jan;10(1):55-9
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  • [Title] New developments in anti-tumor efficacy and malignant transformation of human natural killer cells.
  • For decades, the driving force behind many immunologic studies has been the hope of augmenting anti-cancer therapy through targeted immune-based strategies.
  • The question remains: can immune cells be successfully manipulated to augment chemotherapy and aid in the elimination of malignancy?
  • Such efforts have included work with natural killer (NK) cells, large granular lymphocytes that contribute to the early innate immune response by nonspecifically killing pathogens, virus-infected cells, and tumor cells, and by producing important early immunoregulatory cytokines such as interferon gamma (IFN-gamma).
  • These qualities have made NK cells attractive candidates for therapy aimed at boosting host immunity against tumor cells and infectious pathogens.
  • Recent advances in our understanding of how NK cells select targets for killing have improved our ability to design and test more effective immune-targeted therapies.
  • NK leukemias and lymphomas, while rare, represent a significant challenge to the patients and physicians coping with them, as most lack effective treatment strategies.
  • This brief review will summarize current directions in NK cell immune therapy and give an update on the classification and treatment of NK malignancies.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Cytotoxicity, Immunologic. Hematologic Neoplasms / pathology. Hematologic Neoplasms / therapy. Killer Cells, Natural / pathology

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  • (PMID = 12483112.001).
  • [ISSN] 1065-6251
  • [Journal-full-title] Current opinion in hematology
  • [ISO-abbreviation] Curr. Opin. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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8. Lauro S, Trasatti L, Bria E, Gelibter A, Larosa G, Vecchione A: Malignant bronchial Abrikossoff's tumor and small cell lung cancer: a case report and review. Anticancer Res; 2001 Jan-Feb;21(1B):563-5
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  • [Title] Malignant bronchial Abrikossoff's tumor and small cell lung cancer: a case report and review.
  • Bronchoscopy showed an endobronchial mass; washing cytology was negative and histology findings suggested diagnosis of granular cell tumor (GCT), also called Abrikossoff's tumor.
  • After 3 weeks a new washing cytology test revealed the presence of small cell lung cancer (SCLC).
  • A CT-scan and chest radiography showed a 30% increase in the maximum diameter of the lesion, clinically defining the primary neoplasm as malignant.
  • The patient was referred to our institution and started chemotherapy with cisplatin and etoposide.
  • After 6 cycles of treatment, the CT scan showed complete, disappearance of the neoplasm and bronchoscopy examination showed no endobronchial lesion, defining the mucosal surface as normal.
  • We have reviewed and summarized the international literature with regard to bronchial localization of malignant granular cell tumor and its association with SCLC, therefore concluding that our case is the first malignant endobronchial GCT linked to SCLC.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoma, Small Cell / pathology. Granular Cell Tumor / pathology. Lung Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bronchoalveolar Lavage Fluid / cytology. Bronchoscopy. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Humans. Male. Middle Aged. Remission Induction. Smoking / adverse effects. Tomography, X-Ray Computed

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  • (PMID = 11299804.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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9. Ayadi L, Chaari C, Kallel R, Ayadi K, Khabir A, Jlidi R, Daoud J, Frikha M, Makni S, Sellami-Boudawara T: [Ewing sarcoma osseous and extraosseous : a clinicopathologic study of 29 cases]. Tunis Med; 2010 May;88(5):301-5
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  • [Transliterated title] Sarcome d'Ewing Osseux et Extra Osseux : Etude anatomo-clinique de 29 cas.
  • BACKGROUND: Ewing's sarcoma (ES) is a rare tumour accounting for 10% of primary malignant bone tumours in children and 3% of all childhood malignancies.
  • ES belongs to a group of small round cell tumours.
  • AIM: In this review, we will describe the main clinicopathological features of this rare tumour and discuss its prognosis.
  • RESULTS: 12 patients were male and 17 were female (ratio: 0,8) with a median age of 16 years.
  • The medium size of the tumor was 10,6 cm (range:3-25cm).
  • 27,5% of patients presented with metastatic disease at time of diagnosis.
  • Microscopically, tumour tissue was composed of round, small, blue cells with fine granular chromatin.
  • Tumour cells strongly coexpressed CD99 and vimentin (100%).
  • Systemic treatment consisted of adjuvant chemotherapy (84,2%).
  • Local control was based on and surgery (57,9%) or radiation therapy (36,8%).
  • A good response to chemotherapy was obtained in 37.5%; 13,7% of patients were alive without disease (medium follow up: 169 mois); 34,5% of patients developed metastases (medium follow up : 23 months) and 10,3% developed recurrences (medium follow up :13 months).
  • CONCLUSION: Our study emphasizes two points : the great size of the tumor and the frequent location in flat bone which may explain the poor prognosis of Ewing sarcoma in our series despite the multidisciplinary treatment.

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  • (PMID = 20517824.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
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10. Yilmaz AD, Unlu RE, Orbay H, Sensoz O: Recurrent granular cell tumor: how to treat. J Craniofac Surg; 2007 Sep;18(5):1187-9
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  • [Title] Recurrent granular cell tumor: how to treat.
  • Granular cell tumor is an uncommon lesion usually located in the head and neck region (50%) with a female sex predominance.
  • It is believed to be of primitive neuroectodermal origin.
  • Granular cell tumor has a peculiar clinical behavior ranging from clearly benign, locally aggressive, or manifestly malignant.
  • Treatment is surgical excision, but recurrences are possible.
  • In this article, we present a case of recurrent benign granular cell tumor with the discussion of the treatment modalities.
  • The patient was a 16-year-old girl with a 3-year history of a painless mass on the right side of her neck.
  • The mass was excised two times at different centers and diagnosed as granular cell tumor after the pathologic examination.
  • The time interval between the operations and recurrences was approximately 1 year.
  • The lesion was excised under local anesthesia with a 1-cm safe margin and the resulting defect was closed primarily after undermining of the wound edges.
  • Postoperatively, the wound began to heal with a hypertrophic scar and immediate precautions were taken.
  • Topical steroid treatment and silicone blocks were applied.
  • [MeSH-major] Granular Cell Tumor / pathology. Head and Neck Neoplasms / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adolescent. Cicatrix, Hypertrophic / drug therapy. Female. Humans

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  • (PMID = 17912112.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Kim YH, Kwon R, Jung GJ, Roh MH, Han SY, Kwon HC, Jeong JS, Shin TB, Oh JY, Lee KN: Extrapulmonary small-cell carcinoma of the liver. J Hepatobiliary Pancreat Surg; 2004;11(5):333-7
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  • [Title] Extrapulmonary small-cell carcinoma of the liver.
  • A 53-year-old man was admitted to our hospital for the evaluation of a mass (13 x 10 cm) in the left lobe of the liver seen by imaging studies.
  • On subsequent biopsy of the mass, the lesion was histologically diagnosed as malignant small round-cell tumor, consistent with metastatic small-cell carcinoma.
  • On pathological examination, the mass showed a yellowish-gray granular appearance with multifocal hemorrhage and necrosis.
  • The phenotypes shown by immunohistochemistry revealed characteristic patterns of small-cell carcinoma (neuron-specific enolase [NSE]+, synaptophysin+, c-Kit+, cluster designation [CD]56+, epithelial membrane antigen [EMA]+, cytokeratin [CK]7-).
  • High resolution-computed tomography (HRCT) revealed inactive pulmonary tuberculosis with small calcified tuberculoma in the right upper lobe.
  • The postoperative course was uneventful, and platinum-based chemotherapy (cisplatin, etoposide) was initiated.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Comorbidity. Humans. Immunohistochemistry. Male. Middle Aged. Tomography, X-Ray Computed. Tuberculoma / epidemiology. Tuberculoma / radiography. Tuberculosis, Pulmonary / epidemiology. Tuberculosis, Pulmonary / radiography

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  • (PMID = 15549433.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Ye L, Wu XL, Xu L, Huang Q, Sun L, He Y, Yang KX: [Ovarian steroid cell tumor, not otherwise specified: a clinicopathologic study]. Zhonghua Bing Li Xue Za Zhi; 2007 Aug;36(8):516-20
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  • [Title] [Ovarian steroid cell tumor, not otherwise specified: a clinicopathologic study].
  • OBJECTIVE: To study the clinicopathologic features, diagnostic criteria, differential diagnosis and treatment options of ovarian steroid cell tumor, not otherwise specified (NOS).
  • METHODS: Light microscopy and immunohistochemical study was carried out in 8 cases of ovarian steroid cell tumor, NOS.
  • RESULTS: The 7 cases of benign ovarian steroid cell tumor, NOS were composed mainly of polygonal cells with granular eosinophilic cytoplasm and larger cells with vacuolated cytoplasm.
  • They resembled the architecture of normal adrenal gland, with formation of cell nests and trabeculae.
  • The single case of malignant ovarian steroid cell tumor had evidence of significant cellular pleomorphism, haemorrhage and coagulative tumor necrosis.
  • Immunohistochemical study showed that the tumor cells expressed calretinin and alpha-inhibin.
  • Differential diagnosis included oxyphilic granulosa cell tumor, thecoma, Sertoli cell tumor and clear cell carcinoma.
  • The treatment options of benign ovarian steroid cell tumor, NOS was local excision or ipsilateral salpingo-oophorectomy, while the malignant counterpart should be treated with a combination of surgery and chemotherapy, including administration of GnRH agonist.
  • CONCLUSIONS: Ovarian steroid cell tumor, NOS, is the most common type of ovarian steroid cell tumors.
  • Most of which are associated with a benign clinical outcome.
  • Immunohistochemistry is an important adjunct for diagnosis.
  • The treatment options of ovarian steroid cell tumor, NOS depend on its malignant potential.
  • [MeSH-minor] Adolescent. Adult. Calbindin 2. Diagnosis, Differential. Female. Granulosa Cell Tumor / pathology. Humans. Ovariectomy / methods. Sertoli Cell Tumor / pathology. Thecoma / pathology. Young Adult

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  • (PMID = 17980097.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
  • [Number-of-references] 27
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13. Hao LS, Zhu X, Zhao LH, Qian K, Zhou Y, Bu J, Wu XT: Clear cell adenocarcinoma of colorectum: a case report and review of the literature. Acta Gastroenterol Belg; 2007 Apr-Jun;70(2):235-8
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  • [Title] Clear cell adenocarcinoma of colorectum: a case report and review of the literature.
  • Primary clear cell adenocarcinoma of the colorectum is a rare neoplasm, which differs from ordinary carcinomas of the colorectum in morphological features, but shares some traits of clear cell carcinoma of other organs.
  • The tumor is usually composed of polygonal or oval cells with abundant granular and clear cytoplasm.
  • We report the first case of clear cell adenocarcinoma of the colorectum in China and review the related published cases.
  • The tumor was located in descending colon of a 37-year-old man, and was rich in glycogen but poor in mucin.
  • By immunoperoxidase and histochemical staining, we clarified the clinicopathological characteristics, diagnosis and differential diagnoses, and pursued its potential pathogenesis.
  • In our case, necrosis, high mitotic activity and lymph node metastasis may suggest a highly malignant tumor and an advanced pathological stage.
  • Nevertheless, the patient has survived for one year with the help of operation and postoperative adjuvant chemotherapy.
  • Regardless of the stage and differentiation, surgical therapy and proper adjuvant chemotherapy are effective means to treat the clear cell adenocarcinoma of the colorectum.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Colectomy / methods. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Colonoscopy. Diagnosis, Differential. Follow-Up Studies. Humans. Male

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  • (PMID = 17715642.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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14. Katayama T, Watari M: [An advanced aged case of intrapulmonary metastasis of non-small cell lung cancer successfully controlled with S-1 capsule therapy alone for an extended period]. Gan To Kagaku Ryoho; 2007 May;34(5):753-6
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  • [Title] [An advanced aged case of intrapulmonary metastasis of non-small cell lung cancer successfully controlled with S-1 capsule therapy alone for an extended period].
  • About 7 months after surgery for a non-small cell lung cancer StageIII B, granular shadows were noted on his bilateral lungs on CT; and the level of CA 19-9 , a tumor marker, had increased.
  • These findings led to a diagnosis of intrapulmonary tumor metastasis.
  • Treatment with a platinum-based antineoplastic agent was recommended,but the patient refused it because of his age.
  • Because the tumor appeared to increase in size, treatment was initiated using S-1 capsules (hereafter abbreviated to S-1) alone.
  • Each course consisted of S-1 at a dosage of 100 mg/body/day, twice daily for 21 days, followed by 14 days of drug withdrawal.
  • After the completion of one course, the level of the tumor marker was reduced to normal.
  • Malignant phenomenon exceeding grade 3 was no longer recognized,and it was possible to deliver the scheduled dosage of S-1 throughout the entire series of courses.
  • It has been about 18 months after the S-1 single therapy was started.
  • This therapy is still being continued.
  • [MeSH-major] Antimetabolites, Antineoplastic / administration & dosage. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy. Oxonic Acid / administration & dosage. Tegafur / administration & dosage
  • [MeSH-minor] Aged, 80 and over. Drug Administration Schedule. Drug Combinations. Humans. Male. Quality of Life. Tomography, X-Ray Computed

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  • (PMID = 17496451.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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15. Uchida N, Tsuzuki Y, Ando T, Mochida Y, Yoshikawa M, Sekihara M, Kobayashi M, Ide M, Ohno Y, Kuwano H: Malignant proliferating trichilemmal tumor in the skin over the breast: a case report. Breast Cancer; 2000 Jan;7(1):79-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant proliferating trichilemmal tumor in the skin over the breast: a case report.
  • A proliferating trichilemmal tumor is relatively uncommon.
  • It is composed of multiple cysts consisting of squamous epithelium with trichilemmal keratinization without granular layer interposition.
  • We describe a 67-year-old woman with a malignant proliferating trichilemmal tumor in the skin over the breast.
  • We first misdiagnosed the disease as a primary squamous cell carcinoma of the breast with a metastatic lymph node in the axilla because of the disease site and our unfamiliarity with the disease.
  • Eight months postoperatively, a tumor appeared in her right axilla and progressively enlarged.
  • We subsequently excised the tumor.
  • To the best of our knowledge, only one case of a proliferating trichilemmal tumor occurring in the skin over the breast has been reported.
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Axilla. Carcinoma, Squamous Cell / diagnosis. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Diagnostic Errors. Doxorubicin / administration & dosage. Fadrozole / administration & dosage. Female. Fluorouracil / administration & dosage. Humans. Lymphatic Metastasis. Mastectomy, Radical. Mitomycin / administration & dosage. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / surgery

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  • (PMID = 11029776.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; H3988M64PU / Fadrozole; U3P01618RT / Fluorouracil
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16. Takahashi T, Otani I, Okuda M, Inoue M, Ito K, Sakai M, Koie H, Yamaya Y, Watari T, Sato T, Kanayama K, Tokuriki M: Malignant transformation of T-cell large granular lymphocyte leukemia in a dog. J Vet Med Sci; 2007 Jun;69(6):677-81
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  • [Title] Malignant transformation of T-cell large granular lymphocyte leukemia in a dog.
  • The peripheral lymphocytes were comprised of mostly large granular lymphocytes (LGLs), and flow cytometry showed that they were mostly CD3+8+ T lymphocytes.
  • Clonal rearrangement of the T-cell receptor gene was identified in the peripheral blood, and the dog was therefore diagnosed with LGL chronic leukemia.
  • The dog was subclinical without treatment until hospitalization on day 154, at which point the lymphocytes looked like lymphoblasts and the surface markers changed to CD3-8-.
  • This was regarded as malignant transformation from LGL chronic leukemia to the acute type.
  • Sequential chemotherapy was started, but the dog died on day 190.
  • Necropsy revealed tumor cell infiltration into the heart, skin, and brain.

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  • (PMID = 17611371.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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17. Tsuchido K, Yamada M, Satou T, Otsuki Y, Shimizu S, Kobayashi H: Cytology of sclerosing epithelioid fibrosarcoma in pleural effusion. Diagn Cytopathol; 2010 Oct;38(10):748-53
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  • A 32-year-old man had noticed a tumor in his left buttock 5 years earlier but had not sought treatment because the tumor had been painless.
  • He visited our hospital because the tumor had gradually increased in size.
  • The resected tumor was 12 × 8 × 6 cm in size and had a delineated margin.
  • The histological diagnosis was sclerosing epithelioid fibrosarcoma with a negative surgical margin.
  • Multiple tumor nodules were recognized in both lungs 9 months after the initial surgery, and an excisional biopsy was performed.
  • A histological examination revealed a metastasis of sclerosing epithelioid fibrosarcoma, and chemotherapy was initiated.
  • Pleural disseminations were detected 4 years after the chemotherapy, and the pleural effusion was sampled for cytological examination.
  • The cytological examination revealed several medium-sized cell clusters with moderate overcrowding and an epithelioid cell arrangement; numerous histiocytes and lymphocytes and a small amount of mesothelial cells were observed in the background.
  • The nuclei were pleomorphic with oval, spindle, or cleaved shapes and occasional multinucleation; they were located eccentrically in the cytoplasm and exhibited uniformly fine granular chromatin, a thin nuclear membrane, and several small nucleoli.
  • The above cytological features, coupled with the clinical findings, enabled a diagnosis of sclerosing epithelioid fibrosarcoma.
  • [MeSH-major] Cytodiagnosis. Fibrosarcoma / secondary. Pleural Effusion, Malignant / pathology
  • [MeSH-minor] Adult. Buttocks / pathology. Epithelioid Cells / pathology. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Male. Sclerosis / pathology. Soft Tissue Neoplasms / secondary

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20091700.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Gomard-Mennesson E, Isaac S, Freymond N, Guibert B, Pacheco Y, Devouassoux G: [Pulmonary metastases from Abrikossoff's tumour. Transformation capability of a benign granular cell tumour]. Rev Mal Respir; 2007 Sep;24(7):900-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pulmonary metastases from Abrikossoff's tumour. Transformation capability of a benign granular cell tumour].
  • INTRODUCTION: Abrikossoff's tumour or granular cell tumour is usually benign involving multiple anatomical sites, most frequently the head, neck and airways.
  • Occasional observations of aggressive malignant tumours have been reported, associated with a poor prognosis.
  • CASE REPORT: We report the case of a mammary Abrikossoff's tumour, initially considered benign and treated solely by local surgery.
  • Seven years later the tumour was responsible for the development of sub-cutaneous and pulmonary metastases.
  • Local surgery was again the only treatment given in the absence of evidence for the effectiveness of alternative treatment with chemotherapy or radiotherapy.
  • CONCLUSION: This original observation reports the case of a benign granular cell tumour that underwent malignant transformation after an interval of 7 years as indicated by the clinical progress and the cellular proliferation index Ki-67.
  • [MeSH-major] Breast Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Granular Cell Tumor / secondary. Lung Neoplasms / secondary
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Follow-Up Studies. Humans. Ki-67 Antigen / analysis. S100 Proteins / analysis. Skin Neoplasms / secondary

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  • (PMID = 17925675.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / S100 Proteins
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19. Wang J, Zhu XZ, Zhang RY: [Malignant granular cell tumor: a clinicopathologic analysis of 10 cases with review of literature]. Zhonghua Bing Li Xue Za Zhi; 2004 Dec;33(6):497-502
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  • [Title] [Malignant granular cell tumor: a clinicopathologic analysis of 10 cases with review of literature].
  • OBJECTIVE: To investigate the clinicopathologic features of malignant granular cell tumor (MGCT) and evaluate the histologic criteria for diagnosis of malignancy.
  • Electron microscopy was carried out in 3 cases with available fresh or formalin-fixed tissues.
  • The main presenting symptom was a painless nodule or mass located in the subcutis or deep soft tissue.
  • One case had peripheral nerve symptoms.
  • The tumor size ranged from 2 to 11 cm (mean size = 4.8 cm).
  • Microscopically, the tumor was composed of nests or sheets of polygonal cells which possessed abundant eosinophilic granular cytoplasm and closely resembled its benign counterpart.
  • After careful assessment, 9 cases exhibited at least 3 of the following suspicious features: enlarged vesicular nuclei with prominent nucleoli, nuclear pleomorphism, high nuclear-to-cytoplasmic ratio, spindling of tumor cells, appreciable mitotic activity, and tumor necrosis.
  • In addition, a hitherto undescribed feature characterized by multinucleated tumor cells was observed in 1 case.
  • The remaining case demonstrated benign-appearing features but behaved in a malignant fashion.
  • Follow-up information available in 7 patients revealed local recurrence in 5, metastasis in 4 and tumor-related deaths in 2 patients.
  • In exceptional circumstances, however, the diagnosis relies on clinicopathologic correlation.
  • Wide local excision with regional lymph node dissection remains the mainstay of treatment.
  • Chemotherapy and radiotherapy however have not been shown to significantly improve the clinical course of the disease.
  • The morphologic spectrum of MGCT also includes a rare multinucleated variant.
  • [MeSH-major] Breast Neoplasms / pathology. Granular Cell Tumor / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 15634442.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / S100 Proteins; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Number-of-references] 32
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20. Yokoo H, Kamiya M, Sasaki A, Hirato J, Nakazato Y, Kurachi H: Neurofibromatosis type 1-associated unusual pleomorphic astrocytoma displaying continual malignant progression. Pathol Int; 2001 Jul;51(7):570-7
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  • [Title] Neurofibromatosis type 1-associated unusual pleomorphic astrocytoma displaying continual malignant progression.
  • Patients with neurofibromatosis type 1 (NF1) often have gliomas as a complication, most of which are benign pilocytic astrocytomas which have arisen in optic pathways.
  • In the present case, a 17-year-old girl (at death) with stigmata of NF1, initially had a bulky tumor mass in the left thalamus, developing into the lateral ventricle, at 13 years of age.
  • Partially resected tissue samples showed pleomorphic astrocytoma with abundant xanthoma cells and degenerative structures such as Rosenthal fibers (RF) and eosinophilic granular bodies.
  • The residual tumor was subtotally resected 6 months later, and the tumor histology was essentially similar as before, accompanying the regenerative structures; this was believed to be a good prognostic indicator.
  • After a 2-year, disease-free interval, multiple tumor relapse occurred in June 1997.
  • Partially resected tumor tissues were composed of monotonous small anaplastic cells with prominent proliferative activity.
  • Surprisingly, the tumor cells had retained eosinophilic granules within the cell bodies.
  • Postoperative chemotherapy with procarbazine, MCNU and vincristine (PCV) suppressed the residual tumor dramatically, but the regrowing tumor finally became uncontrollable, leading to the patient's death.
  • TP53 mutation was not detected, while p27 immunopositivity was constantly high during malignant progression, suggesting acquisition of proliferative activity to overcome p53 and p27 inhibitory functions.
  • A review of previously published reports failed to reveal any cases of this type.
  • [MeSH-minor] Adolescent. Antigens, Nuclear. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. DNA Primers / chemistry. DNA, Neoplasm / analysis. Fatal Outcome. Female. Humans. Microfilament Proteins / analysis. Neoplasm Recurrence, Local. Neoplasms, Second Primary / pathology. Nitrosourea Compounds / therapeutic use. Nuclear Proteins / analysis. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Procarbazine / therapeutic use. Tumor Suppressor Protein p53 / analysis. Vincristine / therapeutic use

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  • (PMID = 11472572.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / Biomarkers, Tumor; 0 / DNA Primers; 0 / DNA, Neoplasm; 0 / Microfilament Proteins; 0 / Muscle Proteins; 0 / Nitrosourea Compounds; 0 / Nuclear Proteins; 0 / Tagln protein, mouse; 0 / Tumor Suppressor Protein p53; 35S93Y190K / Procarbazine; 5J49Q6B70F / Vincristine; RYH2T97J77 / ranimustine
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21. Lemos LB, Qu Z, Garg K, Papasozomenos S: Pseudoneoplastic proliferation of histiocytes with paclitaxel-induced ultrastructural changes in a mastectomy specimen. Ann Diagn Pathol; 2004 Oct;8(5):299-304
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 49-year-old Hispanic woman with a T4N1M0 infiltrating duct carcinoma of the left breast underwent four courses of FAC (doxorubicin 86 mg, 5-fluorouracil 860 mg, cyclophosphamide 86 mg, and dexamethasone 10 mg) adjuvant chemotherapy plus four courses of paclitaxel (Taxol; Bristol-Myers Squibb Oncology, Princeton, NJ) and subsequent mastectomy.
  • The tumor shrunk from 6.5 cm to 2.5 cm after the treatment.
  • The residual tumor in the surgical specimen measured 1.5 cm with eight positive out of 24 axillary lymph nodes.
  • The tumor showed typical chemotherapy changes and a massive proliferation of histiocytes that mimicked a neoplasm.
  • A nodular proliferation of the same cells in one axillary node raised the impression of a second malignant tumor in the breast spreading to the node.
  • These findings ruled out histiocytoid carcinoma, granular cell tumor, and Erdheim-Chester disease.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / secondary. Histiocytes / ultrastructure. Mastectomy. Paclitaxel / therapeutic use
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Biomarkers, Tumor. Cell Proliferation / drug effects. Chemotherapy, Adjuvant. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Fluorouracil / administration & dosage. Humans. Intermediate Filaments / drug effects. Intermediate Filaments / ultrastructure. Lymph Nodes / pathology. Lymphatic Metastasis. Mastectomy, Modified Radical. Middle Aged. Sentinel Lymph Node Biopsy. Tubulin / analysis

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  • (PMID = 15494938.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Biomarkers, Tumor; 0 / Tubulin; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; P88XT4IS4D / Paclitaxel; U3P01618RT / Fluorouracil; CAF protocol
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22. Nicoletti F, Arcella A, Iacovelli L, Battaglia G, Giangaspero F, Melchiorri D: Metabotropic glutamate receptors: new targets for the control of tumor growth? Trends Pharmacol Sci; 2007 May;28(5):206-13
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  • [Title] Metabotropic glutamate receptors: new targets for the control of tumor growth?
  • Cancer stem cells are currently a target for the treatment of malignant tumors.
  • Transformed neural stem-progenitor cells of the brain subventricular zone and the external granular layer of the cerebellum are the putative cells of origin of malignant gliomas and medulloblastomas, which are the most frequent malignant brain tumors in adults and children, respectively.
  • At least two receptor subtypes - mGlu(3) and mGlu(4) receptors - control the proliferation of brain tumor cells, whereas mGlu(1) receptors have been implicated in the development of melanomas.
  • We believe that individual mGlu receptor subtypes represent new potential targets for the treatment of several malignant tumors, including brain tumors.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Brain Neoplasms / drug therapy. Drug Delivery Systems. Receptors, Metabotropic Glutamate / drug effects
  • [MeSH-minor] Adult. Animals. Cell Proliferation. Child. Colorectal Neoplasms / drug therapy. Colorectal Neoplasms / physiopathology. Drug Resistance, Neoplasm. Gene Expression. Humans. Ligands. Melanoma / drug therapy. Melanoma / physiopathology. Neoplastic Stem Cells / drug effects. Skin Neoplasms / drug therapy. Skin Neoplasms / physiopathology

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  • (PMID = 17433452.001).
  • [ISSN] 0165-6147
  • [Journal-full-title] Trends in pharmacological sciences
  • [ISO-abbreviation] Trends Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Ligands; 0 / Receptors, Metabotropic Glutamate
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