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1. Kim GH, Choi BG, Lee JN, Park SH, Lee BE, Ryu DY, Song GA, Park DY: [2 cases of gastric mucosa-associated lymphoid tissue lymphoma presenting as a submucosal tumor-like lesion]. Korean J Gastroenterol; 2010 Aug;56(2):103-8
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  • [Title] [2 cases of gastric mucosa-associated lymphoid tissue lymphoma presenting as a submucosal tumor-like lesion].
  • Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the most common form of primary extranodal lymphomas.
  • In most cases, it is developed as multifocal and mucosal lesions, and its initial diagnosis is made by biopsy of suspicious lesions on endoscopy.
  • However, when gastric MALT lymphoma afflict submucosal site without typical mucosal lesion, further procedures are necessary for diagnosis, such as endoscopic mucosal resection and endoscopic ultrasonography.
  • We recently experienced two cases of submucosal tumor-like gastric MALT lymphoma.
  • Treatment modalities included endoscopic mucosal resection, surgery, H. pylori eradication, and/or chemotherapy.
  • [MeSH-major] Gastric Mucosa / pathology. Lymphoma, B-Cell, Marginal Zone / diagnosis
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Endosonography. Female. Gastroscopy. Helicobacter Infections / drug therapy. Helicobacter pylori. Humans. Male. Middle Aged. Stomach Neoplasms / diagnosis

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  • (PMID = 20729622.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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2. Eum EA, Kim H, Kim YM, Woo SJ, Cho JH, Min YJ, Park JH: Anorectal and gastric peripheral T-cell lymphoma, unspecified in a non-AIDS patient. Korean J Intern Med; 2006 Dec;21(4):262-5
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  • [Title] Anorectal and gastric peripheral T-cell lymphoma, unspecified in a non-AIDS patient.
  • We report here on a case of anorectal and gastric peripheral T-cell lymphoma, unspecified (PTCLu) in a non-AIDS patient.
  • Sigmoidoscopy showed anal and rectal submucosal tumor.
  • Multiple round-shaped, flat and elevated lesions were noted on the gastric antrum and body as well.
  • Biopsies of the gastric lesions gave the same diagnosis.
  • He underwent systemic chemotherapy and upfront autologous stem cell transplantation.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / diagnosis. Lymphoma, T-Cell, Peripheral / pathology. Rectal Neoplasms / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Follow-Up Studies. Gastroscopy. Humans. Male. Sigmoidoscopy. Tomography, X-Ray Computed


3. Hirasaki S, Matsubara M, Ikeda F, Taniguchi H, Suzuki S: Gastric inflammatory fibroid polyp treated with Helicobacter pylori eradication therapy. Intern Med; 2007;46(12):855-8
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  • [Title] Gastric inflammatory fibroid polyp treated with Helicobacter pylori eradication therapy.
  • Gastric inflammatory fibroid polyps (IFPs) are rare benign lesions that occur in the distal stomach.
  • We describe a 56-year-old woman with Helicobacter pylori (H. pylori)-positive gastric IFP treated with eradication.
  • Endoscopic examination revealed a submucosal tumor, 35 mm in diameter, with an ulcerated apex at the antrum. H. pylori were positive by both histology and tissue culture, and eradication (a proton pump inhibitor, amoxicillin, and clarithromycin) was performed.
  • After 6 months, the tumor morphologically changed and decreased in size.
  • This case suggests that H. pylori may play a role in the pathogenesis of gastric IFPs.
  • [MeSH-major] Helicobacter Infections / complications. Helicobacter Infections / drug therapy. Helicobacter pylori / isolation & purification. Polyps / drug therapy. Polyps / microbiology. Stomach Neoplasms / drug therapy. Stomach Neoplasms / microbiology
  • [MeSH-minor] Amoxicillin / therapeutic use. Anti-Bacterial Agents / therapeutic use. Clarithromycin / therapeutic use. Drug Therapy, Combination. Female. Gastric Mucosa / microbiology. Humans. Middle Aged. Proton Pump Inhibitors. Treatment Outcome

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  • (PMID = 17575378.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Proton Pump Inhibitors; 804826J2HU / Amoxicillin; H1250JIK0A / Clarithromycin
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4. Taji S, Nomura K, Matsumoto Y, Sakabe H, Yoshida N, Mitsufuji S, Nishida K, Horiike S, Nakamura S, Morita M, Taniwaki M: Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy. World J Gastroenterol; 2005 Jan 7;11(1):89-93
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  • [Title] Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy.
  • AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosa-associated lymphoid tissue (MALT) lymphoma and to determine the clinical value of aneuploidy.
  • METHODS: We studied 13 patients with localized gastric MALT lymphoma of stage E1.
  • Before eradication therapy, the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients.
  • To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissue-fluorescence in situ hybridization (FISH), using chromosome-specific alpha-satellite DNA probes for chromosomes 3,7,12, and 18 and YAC clones for t(11;18)(q21;q21).
  • RESULTS: Seven of the 13 patients had complete regression (CR) in response to H pylori eradication therapy.
  • No patient with CR had submucosal tumor invasion.
  • All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3.
  • CONCLUSION: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities.
  • [MeSH-major] Chromosomes, Human, Pair 3. Helicobacter Infections / drug therapy. Helicobacter pylori. Lymphoma, B-Cell, Marginal Zone / genetics. Stomach Neoplasms / genetics. Trisomy
  • [MeSH-minor] Aged. Anti-Bacterial Agents / therapeutic use. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 18. Female. Follow-Up Studies. Genetic Testing. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Predictive Value of Tests

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  • [CommentIn] World J Gastroenterol. 2005 Dec 14;11(46):7384-5 [16437648.001]
  • (PMID = 15609403.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Other-IDs] NLM/ PMC4205391
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5. Terada T: Gastrointestinal stromal tumor of the digestive organs: a histopathologic study of 31 cases in a single Japanese institute. Int J Clin Exp Pathol; 2009;3(2):162-8
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  • [Title] Gastrointestinal stromal tumor of the digestive organs: a histopathologic study of 31 cases in a single Japanese institute.
  • The author herein reports histopathologic features of 31 surgical cases of gastrointestinal stromal tumor (GIST) of the digestive organs.
  • They consisted of 24 cases of gastric GIST, 1 case of hepatic GIST, 1 case of small intestinal GIST, 4 cases of colon GIST, and 1 case of rectal GIST.
  • Grossly, 23 cases were submucosal tumors, 6 serosa-side tumors, 1 solid tumor in the liver, and 1 rectal polyp.
  • Histologically, 28 cases were of spindle cell type and 3 of epithelioid type.
  • According to mitotic counts and tumor size, the malignant risk was very low in 4 cases, low in 14 cases, intermediate in 9 cases, and high in 4 cases.
  • The chemotherapy was imatinib mesylate in 6 cases, and none in 25 cases.
  • [MeSH-minor] Actins / metabolism. Aged. Aged, 80 and over. Antigens, CD34 / metabolism. Codon. Colonic Neoplasms / pathology. Female. Humans. Immunohistochemistry. Intestinal Neoplasms / pathology. Intestine, Small / pathology. Japan. Liver Neoplasms / pathology. Male. Middle Aged. Point Mutation. Proto-Oncogene Proteins c-kit / metabolism. Receptor, Platelet-Derived Growth Factor alpha / metabolism. Sequence Deletion. Stomach Neoplasms / pathology. Tumor Burden. Vimentin / metabolism

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  • (PMID = 20126584.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Codon; 0 / Vimentin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
  • [Other-IDs] NLM/ PMC2809996
  • [Keywords] NOTNLM ; GIST / KIT / PDGFRA / clinicopathology / desmin / genetics / immunohisology
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6. Hori K, Hanada N, Kusano S, Tsurumoto Y, Sakashita N, Uchino R: [A case of gastric gastrointestinal stromal tumor operated after low-dose chemotherapy with imatinib mesylate]. Gan To Kagaku Ryoho; 2008 Oct;35(10):1749-51
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  • [Title] [A case of gastric gastrointestinal stromal tumor operated after low-dose chemotherapy with imatinib mesylate].
  • Endoscopic findings showed an ulcer on a large submucosal tumor in the stomach.
  • Abodminal CT scan showed a protruding lesion of approximately 13 cm at the lumen of the gastric body.
  • FDG-PET imaging revealed FDG uptake in the gastric body and abdominal cavity.
  • We diagnosed it as GIST with peritoneal dissemination clinically, and treatment with 300 mg of imatinib mesylate was started in December 2006.
  • The main tumor was reduced(reduction rate of 27%)and FDG-PET imaging revealed a decrease in FDG uptake in the main tumor and all disseminated tumors after 5 months of treatment.
  • However, the drug was discontinued for arthritis(grade 3).
  • The present case suggests that low-dose chemotherapy with imatinib mesylate may be useful as a preoperative therapy for a minimal surgery.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Gastrointestinal Stromal Tumors / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Aged. Benzamides. Biopsy. Gastroscopy. Humans. Imatinib Mesylate. Male. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 18931581.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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7. Teraishi F, Suzuki T, Nakamoto M, Chikuba A, Nezu M, Shimamura H, Takiue T, Chikuba H: [Marked response to S-1 chemotherapy for para-aortic lymph node metastasis arising from gastric cancer]. Gan To Kagaku Ryoho; 2007 Nov;34(11):1857-9
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  • [Title] [Marked response to S-1 chemotherapy for para-aortic lymph node metastasis arising from gastric cancer].
  • We report a recurrent case of gastric cancer with para-aortic lymph node metastasis that showed a marked response to systemic chemotherapy consisting of S-1 alone.
  • He had a history of distal gastrectomy due to the advanced gastric cancer.
  • Endoscopy revealed a submucosal tumor-like elevation with central ulcer, and the biopsy specimen was poorly-differentiated adenocarcinoma histologically.
  • CT of the abdomen demonstrated a para-aortic lymph node swelling behind the remnant stomach, indicating an unresectable recurrent gastric cancer.
  • We initially treated the patient with S-1 chemotherapy (60 mgx2/day) by oral administration.
  • His tumor immediately responded to the chemotherapy, and restaging abdominal CT after 2 cycles of chemotherapy showed almost complete regression of lymph node metastasis.
  • The patient has undergone S-1 chemotherapy and currently has remained in remission for more than 21 months with no severe adverse events.
  • The S-1 regime was effective and safe, suggesting that S-1 could be the first-line chemotherapy for recurrent gastric cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Gastric Stump / pathology. Lymph Nodes / pathology. Oxonic Acid / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use
  • [MeSH-minor] Aged. Aorta. Drug Administration Schedule. Drug Combinations. Gastrectomy. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Remission Induction

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  • (PMID = 18030024.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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8. Wada Y, Kamiya N, Asano S, Shinya F: [A case of advanced gastric cancer with Virchow's and paraaortic lymph node metastases successfully resected after combined chemotherapy of low-dose CDDP and 5-FU]. Gan To Kagaku Ryoho; 2001 Jan;28(1):79-82
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  • [Title] [A case of advanced gastric cancer with Virchow's and paraaortic lymph node metastases successfully resected after combined chemotherapy of low-dose CDDP and 5-FU].
  • The patient was a 61-year-old woman who had Stage IV advanced gastric cancer with Virchow's and paraaortic lymph node metastases.
  • The lesions were considered surgically incurable, so she was placed on neoadjuvant chemotherapy consisting of low-dose CDDP and 5-FU.
  • After 3 courses of chemotherapy, the tumor had decreased remarkably in size and Virchow's metastasis had disappeared.
  • She was considered to have a partial response (PR) and underwent distal gastrectomy.
  • Histopathological examination of the primary tumor revealed that almost all cancer cells existed in the mucosal and submucosal layers; few had infiltrated the serosa.
  • The patient received another course of chemotherapy after the operation.
  • Low-dose CDDP and 5-FU therapy was associated with few adverse events in this case, and thought to be effective against advanced gastric cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymph Nodes / pathology. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology
  • [MeSH-minor] Aorta. Cisplatin / administration & dosage. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Humans. Lymphatic Metastasis. Middle Aged

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  • (PMID = 11201385.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; CF regimen
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9. Moldovanu R, Lupaşcu C, Moldovanu CM, Dimofte G, Tuţuianu B, Târcoveanu E, Crumpei F, Ferariu D, Cozma L, Vasilescu A, Filip V, Vlad N: [Gastric stromal tumor. Case report]. Rev Med Chir Soc Med Nat Iasi; 2006 Apr-Jun;110(2):372-6
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  • [Title] [Gastric stromal tumor. Case report].
  • [Transliterated title] Tumoră gastrica stromala. Prezentare de caz.
  • Preoperative endoscopic and barium meal exams showed a submucosal tumor in the gastric fornix.
  • We performed a stapled resection of the gastric fornix associated with Hiss angle reconstruction.
  • CONCLUSIONS: GIST are rare gastric tumors and are usually associated with bleeding and abdominal pain.
  • Surgical resection is a safe and effective treatment.
  • The chemotherapy with tyrosine kinases competitive inhibitors (e.g. imatinib mesylate) is also recommended.
  • [MeSH-major] Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / therapy. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy
  • [MeSH-minor] Antigens, CD34 / analysis. Antineoplastic Agents / therapeutic use. Benzamides. Biomarkers, Tumor / analysis. Gastrectomy / methods. Humans. Imatinib Mesylate. Ki-67 Antigen / analysis. Male. Middle Aged. Piperazines / therapeutic use. Proto-Oncogene Proteins c-kit / analysis. Pyrimidines / therapeutic use. Surgical Stapling. Treatment Outcome

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  • (PMID = 17802947.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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10. Takada J, Watanabe K, Kuraya D, Kina M, Hayashi S, Hamada H, Katsuki Y: [Preoperative S-1/CDDP combination chemotherapy was effective in a case of local advanced gastric cancer]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2451-4
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  • [Title] [Preoperative S-1/CDDP combination chemotherapy was effective in a case of local advanced gastric cancer].
  • INTRODUCTION: The prognosis of type 4 advanced gastric cancer is extremely poor, even the use of multidisciplinary treatment cannot provide satisfactory results.
  • Presented here is a case of highly advanced gastric cancer in which preoperative chemotherapy was effective and resection possible.
  • Type 4 advanced gastric cancer was strongly suspected.
  • Abdominal CT revealed no hepatic mass, but overall thickening of the gastric wall was noticeable and the lymph nodes in the area of the lesser curvature of the stomach and celiac artery were identified.
  • Abdominal ultrasound showed an overall thickening of the gastric wall, and invasion into a portion of the left hepatic lobe and pancreas was suspected.
  • Swelling of the lymph nodes surrounding the stomach was suspected.
  • TREATMENT: Because of gastric cancer with suspected invasion of the left hepatic lobe and pancreas, it was decided to perform preoperative chemotherapy (S-1 + CDDP) and then perform a total gastrectomy.
  • RESULTS: Endoscopy revealed no change in the lesion within the stomach.
  • Abdominal CT showed a reduction in gastric wall thickening.
  • These findings showed preoperative chemotherapy to be effective.
  • Following the chemotherapy, a total gastrectomy in addition to splenectomy and cholecystectomy were performed.
  • Histopathological findings showed MLU, type 5, approx.
  • Along with the formation of fibrous scar tissue, an invasive growth of por 2 poorly differentiated adenocarcinoma was found from the submucosal layer to just beneath the serosal layer.
  • Therapeutic effect of the chemotherapy was Grade 2.
  • Post operative S-1 + CDDP was begun but nausea developed and S-1 was reduced.
  • Because of a decrease of neutrophils and nausea, the therapy was changed to UFT.
  • CONCLUSION: Preoperative chemotherapy (S-1 + CDDP) is a therapy which shows promise in reducing tumor size even in highly advanced gastric cancer.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Stomach Neoplasms / therapy
  • [MeSH-minor] Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Combinations. Female. Gastrectomy. Humans. Middle Aged. Oxonic Acid / administration & dosage. Preoperative Period. Tegafur / administration & dosage

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  • (PMID = 21224603.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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11. Shimada S, Yagi Y, Honmyo U, Shiomori K, Yoshida N, Ogawa M: Involvement of three or more lymph nodes predicts poor prognosis in submucosal gastric carcinoma. Gastric Cancer; 2001;4(2):54-9
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  • [Title] Involvement of three or more lymph nodes predicts poor prognosis in submucosal gastric carcinoma.
  • BACKGROUND: Multivariate analyses has shown that the status of lymph node metastasis and the depth of tumor penetration through the gastric wall are the most important prognostic factors in patients with advanced gastric carcinoma after curative operation.
  • A clinicopathological study was carried out to clarify a simple and optimal prognostic indicator for early gastric cancer.
  • METHODS: Retrospective analyses of 982 patients with early gastric cancer (562 with mucosal [M] and 420 with submucosal [SM] tumor) treated by gastrectomy with D2 lymph node dissection were performed.
  • There were no apparent prognostic indicators in patients with M tumors.
  • All patients with N2 lymph node echelons (according to the Japanese Research Society for Gastric Cancer classification of the draining lymph nodes of the stomach) in the group with one or two positive nodes survived for more than 5 years.
  • CONCLUSION: The sole independent prognostic factor in SM gastric cancer is the involvement of three or more metastatic lymph nodes.
  • We suggest that this simple prognostic indicator for the follow-up of early gastric cancer, and this could lead to potentially effective adjuvant chemotherapy.
  • [MeSH-major] Carcinoma / pathology. Lymphatic Metastasis / pathology. Stomach Neoplasms / pathology

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  • (PMID = 11706761.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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12. Okuda N, Takahashi K, Yagi Y, Ichikawa K, Yamaoka T, Katou T, Kodera Y: [Prolonged complete response obtained by single agent S-1 in a case of peritoneal metastasis from gastric remnant cancer]. Gan To Kagaku Ryoho; 2007 Oct;34(10):1659-61
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  • [Title] [Prolonged complete response obtained by single agent S-1 in a case of peritoneal metastasis from gastric remnant cancer].
  • A 58-year-old man underwent cholecystectomy and partial resection of the stomach with the preoperative diagnosis of acute cholecystitis and submucosal tumor of the stomach.
  • The submucosal tumor was found postoperatively to be a T3 stage gastric cancer with well-differentiated phenotype through histopathologic examination of the resected specimen.
  • The patient rejected a subsequent offer of either reoperation or chemotherapy, and underwent close follow-up.
  • Serum tumor markers rose a few months later, and cancer recurrence was confirmed by the finding of a measurable peritoneal metastasis by computed tomography.
  • He was treated with single agent S-1, obtained a complete response 10 months later, and went on to receive the drug for 42 months.
  • He remains disease-free for over 30 months after cessation of S-1.
  • S-1 is recommended as a first-line chemotherapy for recurrent gastric cancer, but the treatment schedule and follow-up schedule after obtaining a complete response remain an issue.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Gastric Stump. Oxonic Acid / therapeutic use. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / secondary. Stomach Neoplasms / pathology. Tegafur / therapeutic use
  • [MeSH-minor] Drug Combinations. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 17940385.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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13. Niitsu N, Nakamine H, Kohri M, Hayama M, Tamaru J, Iwabuchi K, Tanabe S, Horie R, Higashihara M: Primary gastric T-cell lymphoma not associated with human T-lymphotropic virus type I: a case report and review of the literature. Ann Hematol; 2003 Mar;82(3):197-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary gastric T-cell lymphoma not associated with human T-lymphotropic virus type I: a case report and review of the literature.
  • Primary gastric T-cell lymphoma (PGTL) not associated with human T-lymphotropic virus type I (HTLV-I) is extremely rare and such a case is reported herein.
  • The patient was a 58-year-old Japanese male presenting with submucosal tumor of the stomach identified on endoscopic examination.
  • The lymphoma responded well to chemotherapy and radiation, and the patient was well with no detectable disease 10 months after initiation of therapy.
  • A review of patients with PGTL in the literature revealed a few long-term survivors, and the investigation of therapeutic strategies for PGTL is, therefore, necessary.
  • [MeSH-major] Lymphoma, T-Cell / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Blotting, Southern. Bone Marrow / pathology. Gene Rearrangement, beta-Chain T-Cell Antigen Receptor. Humans. Immunophenotyping. Male. Middle Aged. Neoplasm Staging. Radiotherapy. Receptors, Antigen, T-Cell, alpha-beta / genetics

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  • (PMID = 12634958.001).
  • [ISSN] 0939-5555
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Antigen, T-Cell, alpha-beta
  • [Number-of-references] 23
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14. Takamori H, Kanemitsu K, Tsuji T, Kusano S, Chikamoto A, Okuma T, Iyama K: Metastatic gastric tumor secondary to pancreatic adenocarcinoma. J Gastroenterol; 2005 Feb;40(2):209-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic gastric tumor secondary to pancreatic adenocarcinoma.
  • Metastatic disease, from the pancreas, involving the stomach is an unusual clinical event.
  • We report a patient who suffered from gastric metastasis secondary to pancreatic adenocarcinoma 1 year after pancreatectomy.
  • A 49-year-old woman underwent distal pancreatectomy with intraoperative radiation therapy for cancer of the body of the pancreas in October 2002.
  • Multiple liver metastases were detected on computed tomography (CT) in March 2003.
  • Combination chemotherapy of 5-fluorouracil hepatic arterial continuous infusion and systemic gemcitabine administration led to the disappearance of the liver metastases on CT in September 2003.
  • One month later, she complained of epigastric pain and underwent gastric endoscopy, which revealed a submucosal tumor in the fornix posterior wall.
  • Histological diagnosis of the biopsy specimen was well-differentiated adenocarcinoma, and immunohistochemical studies, using anti-cytokeratin 7 and -20 monoclonal antibodies, were compatible with gastric metastasis from pancreatic carcinoma.
  • A F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) scan revealed a high-uptake lesion, which coincided with the gastric tumor.
  • Histopatholoical examination of the resected specimen revealed submucosal growth of the metastatic cancer (well-differentiated adenocarcinoma).
  • [MeSH-major] Adenocarcinoma / secondary. Pancreatic Neoplasms / pathology. Stomach Neoplasms / secondary
  • [MeSH-minor] CA-19-9 Antigen / blood. Female. Gastric Mucosa / pathology. Gastroscopy. Humans. Immunohistochemistry. Middle Aged. Time Factors

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  • (PMID = 15770407.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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15. Ebisui C, Ohkubo K, Akitake H, Ohtsuka M, Yamanaka C, Maekawa T, Yoshioka S, Hama N, Kashiwazaki M, Taniguchi M, Tsujie M, Konishi M, Fujimoto T: [A case of left inguinal malignant lymphoma occurred after radical operation for gastric cancer and gastrointestinal stromal tumor]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2130-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of left inguinal malignant lymphoma occurred after radical operation for gastric cancer and gastrointestinal stromal tumor].
  • In March 2005, a 70-year-old male patient underwent distal gastrectomy with D2 lymph node dissection for type 3 gastric cancer located in the lower-third of the stomach, and partial gastrectomy for submucosal tumor located in the upper- third of the stomach.
  • A post operative pathological finding of cancer was T2N0P0H0M0 (f-Stage II) and that of submucosal tumor was gastrointestinal stromal tumor.
  • Although the adjuvant chemotherapy of S-1 was administered, it was discontinued because of cerebral infarction.
  • Forty months after the operation, CT scan revealed a left inguinal lymph node swelling and recurrence of gastric cancer was doubted.
  • [MeSH-major] Gastrointestinal Stromal Tumors / surgery. Lymphoma, Follicular / pathology. Stomach Neoplasms / surgery

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  • (PMID = 20037346.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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16. Baba Y, Ishikawa S, Ikeda K, Honda S, Miyanari N, Iyama K, Baba H: A patient with 43 synchronous early gastric carcinomas with a Krukenberg tumor and pericardial metastasis. Gastric Cancer; 2007;10(2):135-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A patient with 43 synchronous early gastric carcinomas with a Krukenberg tumor and pericardial metastasis.
  • Gastroendoscopy disclosed 16 superficial depressed gastric lesions, and the histopathological diagnosis of the biopsy specimens was poorly differentiated adenocarcinoma and signet-ring cell carcinoma.
  • Computed tomography (CT), ultrasonography (US), and positron emission tomography (PET) examinations revealed no other metastasis except for that observed in the ovaries.
  • A postoperative histological examination revealed 43 isolated gastric lesions which were scattered over the entire resected stomach; they were all confined to the mucosa.
  • Cancer cell invasion in the lymphatics was detected only in the submucosal region beneath the main tumor.
  • Both ovarian tumors were diagnosed as metastasis of signet-ring cell carcinoma (Krukenberg tumor).
  • Adjuvant chemotherapy with irinotecan (CPT-11) and low-dose cisplatin (CDDP) was given on an outpatient basis, but 1 year after the surgery, carcinomatous pericarditis occurred.
  • [MeSH-major] Adenocarcinoma / secondary. Heart Neoplasms / secondary. Krukenberg Tumor / secondary. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / secondary. Pericardium / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Cardiac Tamponade / etiology. Cardiac Tamponade / surgery. Fatal Outcome. Female. Gastrectomy. Humans. Lymphatic Metastasis / pathology. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17577625.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Li J, Liu P, Wang H, Yu J, Xie P, Liu X: [Clinical analysis of 31 patients with gastric stromal tumors]. Zhonghua Nei Ke Za Zhi; 2002 Nov;41(11):742-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of 31 patients with gastric stromal tumors].
  • OBJECTIVE: To investigate the clinical manifestations, diagnosis and treatment of gastric stromal tumors.
  • METHODS: 31 patients with gastric stromal tumors treated from 1993, 1 - 2001, 9 were analyzed retrospectively.
  • The distribution of gastric tromal tumors is fundus > body > antrum.
  • Diagnosis of this condition is sometimes difficult and treatment is often delayed because patients usually present with nonspecific abdominal symptoms.
  • The main manifestations of gastric stromal tumors are upper gastrointestinal hemorrhage 61.3% (19/31), 7 patients with acute hemorrhage and 12 with chronic hemorrhage.
  • Gastroscopy, ultrasound gastroscopy, computed tomography, B type ultrasound and upper gastrointestinal X-ray series are helpful to diagnosis.
  • Gastric stromal tumors exhibit consistent immunohistochemical expressions of CD(117) and/or CD(34).
  • The operative treatment is thought of the first choice.
  • Effect of the chemotherapy isn't satisfied.
  • There is no standard chemotherapy for gastric stromal tumors.
  • CONCLUSIONS: Gastric stromal tumor is a kind of separated submucosal tumor which is different from leiomyoma, leiomyosarcoma and neurogenic tumors.
  • Early diagnosis and rational treatment are the keys to improve the prognosis.
  • [MeSH-major] Stomach Neoplasms / physiopathology

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  • (PMID = 12485519.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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18. Ludwig K, Klautke G, Bernhard J, Weiner R: Minimally invasive and local treatment for mucosal early gastric cancer. Surg Endosc; 2005 Oct;19(10):1362-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive and local treatment for mucosal early gastric cancer.
  • BACKGROUND: Early gastric cancer (EGC) can present an indication for local resection procedures under pertain circumstances.
  • METHODS: From 1996 to 2004, of a total of 425 patients with gastric cancer, 58 patients with EGC (13.6%) were prospectively analyzed and observed.
  • Of these, 35 patients had preoperatively diagnosed submucosal infiltration and subsequently underwent gastrectomy and standard lymphnodectomy.
  • One patient displayed lymph node and liver metastasis at the time of diagnosis and received chemotherapy following staging laparoscopy.
  • The rate of lymph node metastasis was 12.5% (n = 35) for submucosal EGC and 4.3% (n = 23) for intramucosal EGC.
  • The average tumor size was 1.2 cm (range 0.3-2.3).
  • The definitive histological findings yielded in all patients tumor-free resection margins without venous or lymphangic infiltration.
  • [MeSH-major] Gastric Mucosa. Gastroscopy. Laparoscopy. Stomach Neoplasms / surgery

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  • (PMID = 16151685.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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19. Tsujitani S, Kaibara N: [Clinical significance of molecular biological detection of micrometastases in gastric carcinoma]. Nihon Geka Gakkai Zasshi; 2001 Oct;102(10):741-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical significance of molecular biological detection of micrometastases in gastric carcinoma].
  • Micrometastases are considered to be a cause of recurrence after curative surgery for gastric cancer.
  • It is important to clarify the clinicopathologic characteristics of micrometastases in the lymph nodes and peritoneal cavity to determine the treatment options in gastric cancer.
  • Micrometastases in the lymph nodes were found in 18% of mucosal cancer, 25% of submucosal cancer, and 65% of T3 (serosal) cancers pecimens, with cancer-free nodes examined by H & E staining.
  • A reduced 5-year survival rate was demonstrated in patients with nodal micrometastases among those with submucosal cancer and those with T3 cancer and cancer-free nodes examined by H & E staining.
  • Molecular biological detection (MBD) of micrometastasis in lavage cytology specimens was performed by RT-PCR of carcinoembryonic antigen mRNA or telomerase activity assay.
  • Therefore indications for lymph node dissection and postoperative chemotherapy should be determined based on the findings of micrometastases in gastric cancer.
  • [MeSH-major] Lymph Nodes / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoembryonic Antigen / analysis. Carcinoembryonic Antigen / genetics. Humans. Keratins / physiology. Lymphatic Metastasis. Peritoneal Neoplasms / secondary. Prognosis. RNA, Messenger / analysis. Survival Rate

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  • (PMID = 11680998.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / RNA, Messenger; 68238-35-7 / Keratins
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20. Iwazawa T, Kinuta M, Yano H, Matsui S, Tamagaki S, Yasue A, Okada K, Kanoh T, Tono T, Nakano Y, Okamoto S, Monden T: An oral anticancer drug, TS-1, enabled a patient with advanced gastric cancer with Virchow's metastasis to receive curative resection. Gastric Cancer; 2002;5(2):96-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An oral anticancer drug, TS-1, enabled a patient with advanced gastric cancer with Virchow's metastasis to receive curative resection.
  • We encountered a patient with advanced gastric cancer, with Virchow's lymph node metastasis, who subsequently underwent curative resection after neoadjuvant chemotherapy with the newly developed oral anticancer drug, TS-1.
  • The patient was a 67-year-old woman who had a type 2 tumor in the middle third of the stomach, and Virchow's lymph node metastasis, which was diagnosed by fine-needle aspiration cytology; she also had swollen paraaortic lymph nodes.
  • Although grade 2 stomatitis interrupted the therapy on day 21 of the second course and on day 7 of the third course, the type 2 tumor showed marked remission (partial response;.
  • Eleven weeks after the completion of the TS-1 treatment, total gastric resection with D3 lymph node dissection was performed.
  • Histopathological examination revealed tumor involvement only in the mucosal and submucosal layers of the stomach and the no. 4d lymph node.
  • Most of the tumor was replaced with fibrosis with granulomatous change in the muscularis propria of the stomach and in the no. 3, no. 6, and no. 7 lymph nodes.
  • This may be the first report of a patient with advanced gastric cancer with Virchow's lymph node metastasis who successfully received curative resection following neoadjuvant chemotherapy with a single oral anticancer drug.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Oxonic Acid / therapeutic use. Pyridines / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use
  • [MeSH-minor] Administration, Oral. Aged. Chemotherapy, Adjuvant. Drug Combinations. Female. Gastrectomy. Humans. Neoplasm Staging

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  • (PMID = 12111585.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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21. Shimoyama S, Nozaki K, Kaminishi M, Motoi N, Murakami T: A rare case of alpha-fetoprotein-producing early gastric cancer. Hepatogastroenterology; 2001 May-Jun;48(39):687-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of alpha-fetoprotein-producing early gastric cancer.
  • Most of the alpha-fetoprotein-producing gastric cancer is advanced at the time of presentation, and alpha-fetoprotein-producing early gastric cancer is extremely rare.
  • Alpha-fetoprotein-producing early gastric cancer was confirmed by immunohistochemistry and serum analysis of alpha-fetoprotein concentration.
  • A 71-year-old-male patient underwent total gastrectomy due to a depressed type of gastric cancer in the upper third of the stomach.
  • Histological examination revealed that the tumor invasion was limited to the submucosal layer, and that the tumor consisted of both well-differentiated, papillo-tubular growth areas and trabecular and medullary growth areas resembling hepatoid carcinoma.
  • The predominance of a strong-bound fraction with lectin, which was demonstrated by lens culinalis agglutinin affinity chromatography, suggests that the alpha-fetoprotein carbohydrate chain species in the present case was a hepatic type.
  • The patient received adjuvant intravenous chemotherapy consisting of 5-fluorouracil and cisplatin, and has been further supported by oral 5-fluorouracil administration.
  • We report here a rare case of alpha-fetoprotein producing early gastric cancer.
  • The alpha-fetoprotein carbohydrate phenotype analysis helps to consider the primary differentiation of alpha-fetoprotein-producing gastric cancer.
  • [MeSH-major] Adenocarcinoma / pathology. Stomach Neoplasms / pathology. alpha-Fetoproteins / metabolism
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Chemotherapy, Adjuvant. Combined Modality Therapy. Gastrectomy. Gastric Mucosa / pathology. Humans. Male. Neoplasm Staging

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  • (PMID = 11462904.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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22. Osako T, Okamura K, Inoue K, Taneda T, Tsuruzoe S, Fukuda S: [Three cases of advanced gastric cancer resected after successful treatment with the novel oral anticancer drug TS-1]. Gan To Kagaku Ryoho; 2001 May;28(5):677-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Three cases of advanced gastric cancer resected after successful treatment with the novel oral anticancer drug TS-1].
  • We operated on 3 patients with advanced gastric cancer after successful treatment with novel oral 5-fluorouracil derivatives (TS-1).
  • In all 3 patients, gastrointestinal fiberscopy revealed a considerable reduction in the tumor after oral administration of TS-1 in our clinic.
  • Pathologically, no cancer cells were found in the resected stomach and a few cancer cells were found only in resected lymph nodes.
  • In case 2, who underwent surgery after an interval of 7 days following oral administration of TS-1 for 14 days, a few cancer cells were found only in the submucosal layer of the stomach and no viable cancer cells remained in the metastasized lymph nodes.
  • The pathological effectiveness of chemotherapy was grade 2 or 3 in each case.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Gastrectomy. Oxonic Acid / therapeutic use. Pyridines / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use
  • [MeSH-minor] Administration, Oral. Aged. Drug Combinations. Humans. Male. Middle Aged. Neoadjuvant Therapy

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  • (PMID = 11383217.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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23. Kusayanagi S, Konishi K, Miyasaka N, Sasaki K, Kurahashi T, Kaneko K, Akita Y, Yoshikawa N, Kusano M, Yamochi T, Kushima M, Mitamura K: Primary small cell carcinoma of the stomach. J Gastroenterol Hepatol; 2003 Jun;18(6):743-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary small cell carcinoma of the stomach.
  • We report on an 80-year-old man with primary gastric small cell carcinoma (SmCC).
  • An upper gastrointestinal examination revealed an irregularly ulcerated tumor, 60 mm in diameter, on the lesser curvature of the stomach body extending to the cardia.
  • An endoscopic biopsy revealed a solid proliferation of intermediate-sized tumor cells with hyperchromatic nuclei and scanty cytoplasm.
  • No tumor was detected on examination of the chest.
  • Therefore, primary gastric SmCC was diagnosed preoperatively.
  • To date, only 38 cases of primary gastric SmCC, including our case, have been reported.
  • In the reported cases of gastric SmCC, the endoscopic findings frequently indicated a submucosal tumor.
  • Gastric SmCC is clinically aggressive and has an extremely poor prognosis, even when discovered at an early stage.
  • Most patients with gastric SmCC die within 1 year of diagnosis.
  • Although a standard treatment for gastric SmCC has not been established, intensive chemotherapy should be considered to promote long-term survival.
  • We believe that careful examination, including immunohistochemical investigation, is necessary for determining the therapeutic strategy whenever gastric SmCC is suspected during endoscopy.
  • [MeSH-major] Carcinoma, Small Cell / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor. Biopsy. Carcinoembryonic Antigen. Chromogranin A. Chromogranins. Endoscopy, Gastrointestinal. Gastric Mucosa / pathology. Humans. Immunohistochemistry. Male. Phosphopyruvate Hydratase

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  • (PMID = 12753162.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Chromogranin A; 0 / Chromogranins; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Number-of-references] 27
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24. Sasaki K, Doi T, Matsumoto G, Tsuruta K, Okamoto A, Funada N: [Metastatic gastrointestinal stromal tumors responded to the treatment with STI571 after polysurgery for recurrent lesions--report of two cases]. Gan To Kagaku Ryoho; 2003 Jul;30(7):1021-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastatic gastrointestinal stromal tumors responded to the treatment with STI571 after polysurgery for recurrent lesions--report of two cases].
  • Two cases of metastatic gastrointestinal stromal tumors (GIST) that had responded to the treatment with STI571 were presented.
  • Case 1 was a 49-year-old woman who had undergone proximal gastrectomy because of a giant submucosal tumor of the stomach.
  • For 21 months after surgery, the patient received repeated tumor removal four times due to hepatic metastasis and/or peritoneal recurrence.
  • Thereafter, the treatment with STI571 at a dose of 400 mg/day was initiated.
  • Case 2 was a 61-year-old man who underwent emergency surgery for a retroperitoneal tumor that had caused massive intestinal hemorrhage resulting in critical shock.
  • The patient underwent the surgery three times for recurrent lesions.
  • Because further tumor removal had become nearly impossible, STI571 at a dose of 400 mg/day was administered 35 months after initial surgery.
  • Six months after treatment the hepatic lesions were shrunk, but the number of retroperitoneal lesions increased.
  • These clinical observations suggest that ST1571 therapy for metastatic lesions from GIST may be preferred over aggressive, repeated tumor removal.
  • [MeSH-major] Liver Neoplasms / drug therapy. Pyrimidines / therapeutic use. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Administration, Oral. Benzamides. Combined Modality Therapy. Drug Administration Schedule. Female. Gastrectomy. Hepatectomy. Humans. Imatinib Mesylate. Male. Middle Aged. Piperazines. Proto-Oncogene Proteins c-kit / analysis. Stromal Cells / pathology

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  • (PMID = 12894723.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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25. Wada Y, Yamamoto T, Kita Y, Fukunishi S, Ashida K: [An autopsy case of encephalopathy associated with small cell carcinoma of the stomach with nonconvulsive status epilepticus resembling Creutzfeldt-Jakob disease]. No To Shinkei; 2003 May;55(5):423-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [An autopsy case of encephalopathy associated with small cell carcinoma of the stomach with nonconvulsive status epilepticus resembling Creutzfeldt-Jakob disease].
  • A 64-year-old man developed progressive dementia and altered consciousness with myoclonus over 2 months.
  • Now CT scans of the abdomen showed enlarged periaortic lymph node and endoscopic ultrasonography disclosed a submucosal tumor of the stomach.
  • Chemotherapy didn't work well for the tumor and the patient underwent a downhill course, although his mental and neurological manifestation were mostly unremarkable.
  • Autopsy confirmed small cell carcinoma originating in the stomach and metastases in the liver and lungs.
  • [MeSH-major] Brain Diseases / pathology. Carcinoma, Small Cell / complications. Creutzfeldt-Jakob Syndrome / diagnosis. Status Epilepticus / diagnosis. Stomach Neoplasms / complications


26. Zenda T, Tominaga K, Choto S, Okada T, Kaneko S, Minato H: [Diffuse large B-cell lymphoma initially manifested by massive ascites and a small gastric lesion, clinically mimicking primary effusion lymphoma (PEL) in the abdominal cavity: a case report and review of the literature on Japanese PEL patients]. Nihon Shokakibyo Gakkai Zasshi; 2007 Dec;104(12):1772-80
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  • [Title] [Diffuse large B-cell lymphoma initially manifested by massive ascites and a small gastric lesion, clinically mimicking primary effusion lymphoma (PEL) in the abdominal cavity: a case report and review of the literature on Japanese PEL patients].
  • While lymphoma cells (diffuse large B-cell lymphoma: DLBCL) were detected in the ascites, pleural effusion, cerebrospinal fluid and bone marrow, no tumor masses other than a submucosal lymphoma lesion in the stomach only 1 cm in diameter were identified.
  • The patient was treated with chemotherapy including rituximab (R-CHOP-ESHAP) and injection of methotrexate and dexamethasone into the medullary cavity as well as radiation to the whole brain, and achieved complete remission 4 months later.
  • The present case suggests that DLBCL can initially manifest as a form of effusion lymphoma with minimum solid tumor component.
  • [MeSH-minor] Ascites / complications. Diagnosis, Differential. Humans. Male. Middle Aged. Stomach Neoplasms / pathology


27. Fujita H, Nishikori M, Takaori-Kondo A, Yoshinaga N, Ohara Y, Ishikawa T, Haga H, Uchiyama T: A case of HIV-associated lymphoproliferative disease that was successfully treated with highly active antiretroviral therapy. Int J Hematol; 2010 May;91(4):692-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of HIV-associated lymphoproliferative disease that was successfully treated with highly active antiretroviral therapy.
  • We report a case of a 41-year-old male with human immunodeficiency virus (HIV)-associated lymphoproliferative disease (LPD) who was successfully treated with highly active antiretroviral therapy (HAART).
  • He presented with epigastralgia, and an upper endoscopic examination revealed submucosal tumors and ulcerations in his stomach.
  • He was treated with CHOP chemotherapy but the response was poor.
  • The gastric and inguinal lymph node specimens were re-evaluated and diagnoses of HIV-LPD and HIV lymphadenitis were made, respectively.
  • He was treated with HAART and achieved complete remission and has remained tumor-free for 20 months.
  • To the best of our knowledge, there is no previous report in which HIV-LPD was successfully treated with antiretroviral therapy alone.
  • It is assumed that HAART resulted in the restoration of anti-tumor immunity in this case, which led to the eradication of LPD cells.
  • [MeSH-major] Antiretroviral Therapy, Highly Active. HIV Infections / complications. HIV Infections / drug therapy. Lymphoproliferative Disorders / virology
  • [MeSH-minor] Adult. Biopsy. Endoscopy, Gastrointestinal. Humans. Lymph Nodes / pathology. Lymphadenitis / diagnosis. Lymphadenitis / immunology. Lymphadenitis / virology. Male. Positron-Emission Tomography. Remission Induction

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  • (PMID = 20217283.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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28. Terashima M, Abe K, Takeda Y, Saito K, Uesugi N, Kato K, Sato K, Maekawa T: [A patient with metastatic gastrointestinal stromal tumor who responded to STI571]. Gan To Kagaku Ryoho; 2002 Apr;29(4):607-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A patient with metastatic gastrointestinal stromal tumor who responded to STI571].
  • We report a case of gastrointestinal stromal tumor (GIST) with multiple hepatic metastases that responded to tyrosine kinase inhibitor STI571.
  • A 30-year-old woman underwent total gastrectomy on July 10, 1998, with a diagnosis of submucosal tumor of the stomach.
  • The patient underwent tumor excision due to peritoneal recurrence on May 1, 2000 and November 13, 2000.
  • Treatment with STI571 at a dose of 400 mg/day for 28 days was initiated on September 14, 2000.
  • CAT scan showed rapid tumor shrinkage after 3 weeks of treatment (reduction rate of 56%) and the response continued after 7 weeks of treatment (reduction rate of 71%).
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Piperazines / therapeutic use. Protein-Tyrosine Kinases / antagonists & inhibitors. Pyrimidines / therapeutic use. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Benzamides. Cell Division. Drug Administration Schedule. Female. Humans. Imatinib Mesylate. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary

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  • (PMID = 11977548.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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29. Shomura H, Nakano S, Funai T, Akabane H, Inagaki M, Yanagida N, Kudo T, Orimo T, Oikawa F, Emoto S, Yoneya R: [A case of metastasis to the stomach from primary adenocarcinoma of the lung cancer]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2481-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of metastasis to the stomach from primary adenocarcinoma of the lung cancer].
  • We report a case of gastric metastasis of lung cancer performed gastrectomy for the primary foci.
  • Four years later, positron emission tomography (PET)-CT revealed a tumor in the stomach and para-aortic lymph nodes swelling.
  • The submucosal tumor was showed in the cardia by endoscopic examination.
  • With the diagnosis of gastric metastasis from lung cancer, she was operated on.
  • Since then, she was treated with adjuvant chemotherapy as an outpatient.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Lung Neoplasms / pathology. Stomach Neoplasms / secondary

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  • (PMID = 21224613.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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30. Kikuchi Y, Matsui T, Hisabe T, Wada Y, Hoashi T, Tsuda S, Yao T, Iwashita A, Imamura K: Deep infiltrative low-grade MALT (mucosal-associated lymphoid tissue) colonic lymphomas that regressed as a result of antibiotic administration: endoscopic ultrasound evaluation. J Gastroenterol; 2005 Aug;40(8):843-7
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  • [Title] Deep infiltrative low-grade MALT (mucosal-associated lymphoid tissue) colonic lymphomas that regressed as a result of antibiotic administration: endoscopic ultrasound evaluation.
  • Since 1997 we have experienced three cases of low-grade colonic mucosal-associated lymphoid tissue (MALT) lymphomas.
  • The depth of tumor invasion was evaluated by endoscopic ultrasonography (EUS) and the mass lesions were all diagnosed as having extended beyond the deep region of the submucosal layer.
  • Although all of these patients tested negative for gastric Helicobacter pylori, their tumor lesions regressed after antibiotic treatment in accordance with H. pylori eradication therapy.
  • In general, consensus has been reached regarding antibiotic therapy for gastric MALT lymphomas.
  • However, as a prerequisite for antibiotic therapy, the therapy has been deemed effective against these gastric tumors if the extent of infiltration, as evaluated by EUS, is limited to the mucosal layer or the superficial region of the submucosal layer.
  • Based on the therapeutic outcomes seen in the three patients studied here, it is suggested that antibiotic therapy might be useful in treating MALT lymphomas of the colon, even in patients with advanced invasive tumors, in contrast to the extent of the lesions in the stomach suitable for antibiotic treatment.
  • The success of the antibiotic treatment also suggests that MALT lymphomas may be caused by unknown luminal microorganisms, other than H. pylori.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Colonic Neoplasms / diagnostic imaging. Colonic Neoplasms / drug therapy. Endosonography. Lymphoma, B-Cell, Marginal Zone / diagnostic imaging. Lymphoma, B-Cell, Marginal Zone / drug therapy
  • [MeSH-minor] Aged. Aged, 80 and over. Amoxicillin / therapeutic use. Clarithromycin / therapeutic use. Female. Helicobacter pylori / isolation & purification. Humans. Male

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  • (PMID = 16143891.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 804826J2HU / Amoxicillin; H1250JIK0A / Clarithromycin
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31. Chou L: [Clinical and research advances in oral AIDS]. Shanghai Kou Qiang Yi Xue; 2001 Sep;10(3):193-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Therefore, knowledge of HIV infection has become a critically important requirement for professionals responsible for oral health care delivery and early detection of HIV infection.
  • Because of decreased gastric acid secretion in most HIV-infected patients, fluconazole, the antifungal drug that can be absorbed easily despite the gastric pH change, would be the best choice for systemic antifungal treatment.
  • Our latest study indicated that the infection of Epstein-Barr virus (EBV) might not be the definitive criteria for the diagnosis of HL and that the reciprocal activation of EBV and HIV within the epithelium may be the critical event in the development of HL.
  • Our study demonstrated that CD4-bearing oral mucosal Langerhans cells (LC) could be the target of HIV infection, the effector to alter LC number and its antigen processing capability, as well as the vector to pass the virus to submucosal memory T cells, which would be responsible for the second pathway of HIV transmission through mucosal contact with HIV.
  • KS has been the most common tumor associated with HIV infection and has been one of the AIDS defining diseases.
  • The latest study indicated that this tumor is related to opportunistic infection of human herpes simplex virus 8.
  • Because of its reactive type nature clinically and histologically, KS has now been considered a pseudomalignancy.
  • Intralesional injection of cytotoxic drugs has been effective in treatment.
  • Since HIV-infected patients have demonstrated a higher propensity for developing allergic and adverse reactions to antibiotics, bleeding tendency and slow wound healing after dental surgery, decreased levels of neutrophil counts, and xerostomia, a modified dental therapy would be essential for management of HIV-infected dental patients.

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  • (PMID = 14993986.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] China
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