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1. Théou N, Gil S, Devocelle A, Julié C, Lavergne-Slove A, Beauchet A, Callard P, Farinotti R, Le Cesne A, Lemoine A, Faivre-Bonhomme L, Emile JF: Multidrug resistance proteins in gastrointestinal stromal tumors: site-dependent expression and initial response to imatinib. Clin Cancer Res; 2005 Nov 01;11(21):7593-8
Hazardous Substances Data Bank. IMATINIB MESYLATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumors of the digestive tract and respond poorly to chemotherapy.
  • A tyrosine kinase inhibitor treatment, imatinib mesylate, was recently shown to have antitumor effects in metastatic patients.
  • However, this drug is a substrate for multidrug resistance (MDR) proteins.
  • ABCB1 was expressed in all gastric GISTs, but in only 67% of nongastric GISTs.
  • The levels of these MDR proteins in gastric GISTs were higher for ABCB1 (P = 0.007) and lower for ABCC1 (P = 0.004) compared with nongastric GISTs.
  • These results confirm that gastric and nongastric GISTs have different biological characteristics and suggest that MDR proteins do not impair the initial response of the tumor to imatinib.
  • [MeSH-major] Drug Resistance, Multiple. Drug Resistance, Neoplasm. Gastrointestinal Neoplasms / drug therapy. Gene Expression Regulation, Neoplastic. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] ATP Binding Cassette Transporter, Sub-Family G, Member 2. ATP-Binding Cassette Transporters / biosynthesis. ATP-Binding Cassette, Sub-Family B, Member 1 / biosynthesis. Adult. Aged. Antineoplastic Agents / pharmacology. Benzamides. Blotting, Western. Enzyme Inhibitors / therapeutic use. Female. Humans. Imatinib Mesylate. Immunohistochemistry. Leiomyosarcoma / metabolism. Male. Middle Aged. Multidrug Resistance-Associated Proteins / biosynthesis. Neoplasm Proteins / biosynthesis. Protein Kinase Inhibitors / pharmacology. Protein-Tyrosine Kinases / antagonists & inhibitors. Risk

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  • (PMID = 16278376.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / ATP Binding Cassette Transporter, Sub-Family G, Member 2; 0 / ATP-Binding Cassette Transporters; 0 / ATP-Binding Cassette, Sub-Family B, Member 1; 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Enzyme Inhibitors; 0 / Multidrug Resistance-Associated Proteins; 0 / Neoplasm Proteins; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases; Y49M64GZ4Q / multidrug resistance-associated protein 1
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2. Pérez-Gutiérrez S, González-Cámpora R, Amérigo-Navarro J, Beato-Moreno A, Sánchez-León M, Pareja Megía JM, Virizuela-Echaburu JA, López-Beltrán A: Expression of P-glycoprotein and metallothionein in gastrointestinal stromal tumor and leiomyosarcomas. Clinical implications. Pathol Oncol Res; 2007;13(3):203-8

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  • P-GP expression was unrelated to anatomic location (gastric vs. intestinal) in GIST (39/45 vs. 35/43, p=0.770) and in GI-LMS (0/2 vs. 2/6, p=1.000).
  • MT expression was unrelated to the anatomic location (gastric vs. intestinal) in GIST (7/45 vs. 6/43) and GI-LMS (0/2 vs. 1/6) (p=1.000 and p=0.1000, respectively).
  • Differential expression of P-GP and MT might explain the known variability in response to systemic chemotherapy in these tumors.
  • Detection of P-GP and MT seems to add certain prognostic value in GIST (MT) or GI-LMS (P-GP).
  • [MeSH-major] Gastrointestinal Neoplasms / metabolism. Gastrointestinal Stromal Tumors / metabolism. Leiomyosarcoma / metabolism. Metallothionein / metabolism. P-Glycoprotein / metabolism
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Drug Resistance, Neoplasm. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Prognosis. Survival Analysis

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  • (PMID = 17922049.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / P-Glycoprotein; 9038-94-2 / Metallothionein
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3. Swann HM, Holt DE: Canine gastric adenocarcinoma and leiomyosarcoma: a retrospective study of 21 cases (1986-1999) and literature review. J Am Anim Hosp Assoc; 2002 Mar-Apr;38(2):157-64
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  • [Title] Canine gastric adenocarcinoma and leiomyosarcoma: a retrospective study of 21 cases (1986-1999) and literature review.
  • This retrospective study describes the clinical course, treatment, and outcome of 21 dogs with gastric adenocarcinomas (n=19) and leiomyosarcomas (n=2).
  • Medical records from 1986 to 1999 were reviewed for signalment, weight, diagnosis, tumor location, clinical signs, radiographic imaging procedures, surgical procedures, chemotherapy, duration of follow-up monitoring, outcome, cause of death, metastatic rate, metastatic sites, and method of detection of metastasis.
  • Fourteen of 19 (74%) dogs with gastric adenocarcinomas had metastasis.
  • Metastatic sites included gastric lymph nodes, omentum, liver, duodenum, pancreas, spleen, esophagus, adrenal glands, and lungs.
  • Both cases of a gastric leiomyosarcoma had metastatic disease involving the liver (n=2) and duodenum (n=1).
  • Surgery, consisting of either a Billroth I or a gastrojejunostomy, provided immediate relief of the gastric outflow obstruction and clinical improvement in the early postoperative period.
  • The beneficial effects of chemotherapy alone or adjuvant chemotherapy are still unknown.
  • The long-term prognosis for most cases of gastric adenocarcinomas and leiomyosarcomas is poor because of the presence of advanced disease.
  • Surgical resection, however, does alleviate gastric outflow obstruction in the immediate postoperative period.
  • [MeSH-major] Adenocarcinoma / veterinary. Dog Diseases / epidemiology. Leiomyosarcoma / veterinary. Stomach Neoplasms / veterinary
  • [MeSH-minor] Animals. Antineoplastic Agents / therapeutic use. Dogs. Female. Male. Neoplasm Metastasis. Pennsylvania / epidemiology. Records as Topic / veterinary. Retrospective Studies

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  • (PMID = 11908834.001).
  • [ISSN] 0587-2871
  • [Journal-full-title] Journal of the American Animal Hospital Association
  • [ISO-abbreviation] J Am Anim Hosp Assoc
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 22
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4. Nakajima Y, Kakizaki S, Kanda D, Shimada Y, Sohara N, Sato K, Takagi H, Mori M, Watanabe H: Pancreatic and gastric metastases of leiomyosarcoma arising in the left leg. Int J Clin Oncol; 2005 Oct;10(5):342-7
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  • [Title] Pancreatic and gastric metastases of leiomyosarcoma arising in the left leg.
  • Pancreatic or gastric metastases from other primary malignancies are rare, especially from leiomyosarcoma.
  • We report a case of leiomyosarcoma in the left lower leg with metastases to the pancreas and stomach.
  • Two years before presentation at our hospital, he had undergone surgical resection of leiomyosarcoma in the left lower leg and systemic chemotherapy for multiple metastatic tumors in the lung.
  • On admission, endoscopic examination and computed tomography were performed for a routine checkup to exclude esophageal varices and liver tumor.
  • Although the patient had no specific symptoms, multiple gastric and pancreatic metastases were identified by endoscopy and computed tomography, respectively.
  • In general, metastases to the pancreas and stomach are rare.
  • We discuss the clinical and diagnostic findings of pancreatic and gastric metastases by reviewing previously reported cases.
  • [MeSH-major] Leg. Leiomyosarcoma / secondary. Muscle Neoplasms / pathology. Pancreatic Neoplasms / secondary. Stomach Neoplasms / secondary

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  • (PMID = 16247662.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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5. Li J, Liu P, Wang H, Yu J, Xie P, Liu X: [Clinical analysis of 31 patients with gastric stromal tumors]. Zhonghua Nei Ke Za Zhi; 2002 Nov;41(11):742-5
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  • [Title] [Clinical analysis of 31 patients with gastric stromal tumors].
  • OBJECTIVE: To investigate the clinical manifestations, diagnosis and treatment of gastric stromal tumors.
  • METHODS: 31 patients with gastric stromal tumors treated from 1993, 1 - 2001, 9 were analyzed retrospectively.
  • The distribution of gastric tromal tumors is fundus > body > antrum.
  • Diagnosis of this condition is sometimes difficult and treatment is often delayed because patients usually present with nonspecific abdominal symptoms.
  • The main manifestations of gastric stromal tumors are upper gastrointestinal hemorrhage 61.3% (19/31), 7 patients with acute hemorrhage and 12 with chronic hemorrhage.
  • Gastroscopy, ultrasound gastroscopy, computed tomography, B type ultrasound and upper gastrointestinal X-ray series are helpful to diagnosis.
  • But the final diagnosis is decided by pathological and immunohistochemistry examinations.
  • Gastric stromal tumors exhibit consistent immunohistochemical expressions of CD(117) and/or CD(34).
  • The operative treatment is thought of the first choice.
  • Effect of the chemotherapy isn't satisfied.
  • There is no standard chemotherapy for gastric stromal tumors.
  • CONCLUSIONS: Gastric stromal tumor is a kind of separated submucosal tumor which is different from leiomyoma, leiomyosarcoma and neurogenic tumors.
  • Pathological and immunohistochemistry inspectations are very important to make clear diagnosis.
  • Early diagnosis and rational treatment are the keys to improve the prognosis.
  • [MeSH-major] Stomach Neoplasms / physiopathology

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  • (PMID = 12485519.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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6. Vogl TJ, Zangos S, Eichler K, Selby JB, Bauer RW: Palliative hepatic intraarterial chemotherapy (HIC) using a novel combination of gemcitabine and mitomycin C: results in hepatic metastases. Eur Radiol; 2008 Mar;18(3):468-76
Hazardous Substances Data Bank. MITOMYCIN C .

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  • [Title] Palliative hepatic intraarterial chemotherapy (HIC) using a novel combination of gemcitabine and mitomycin C: results in hepatic metastases.
  • To evaluate repeated hepatic intraarterial chemotherapy (HIC) as a palliative treatment option for unresectable cholangiocarcinoma and liver metastases of various origins that were progressive under systemic chemotherapy.
  • Treated tumor entities were colorectal carcinoma (CRC) (n = 12), breast cancer (BC) (n = 12), cholangiocarcinoma (CCC) (n = 10), pancreatic (n = 4), ovarian (n = 3), gastric, cervical, papillary (each n = 2), prostate, esophageal carcinoma, leiomyosarcoma (each n = 1), cancer of unknown primacy (CUP) (n = 5).
  • All patients tolerated the treatment well without any major side effects or complications.
  • HIC with gemcitabine/mitomycin is a safe, minimally invasive, palliative treatment for hepatic metastases that are progressive under systemic chemotherapy.
  • The treatment yields respectable tumor control rates in CRC and BC patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Palliative Care
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Antimetabolites, Antineoplastic / administration & dosage. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Breast Neoplasms / pathology. Cholangiocarcinoma / pathology. Colorectal Neoplasms / pathology. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Female. Humans. Injections, Intra-Arterial. Male. Middle Aged. Mitomycin / administration & dosage. Treatment Outcome

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  • (PMID = 17938935.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 50SG953SK6 / Mitomycin; B76N6SBZ8R / gemcitabine
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7. Neagu S, Zărnescu NO, Costea R, Stamatoiu A, Badea V, Dumitrescu C, Grădinaru S, Sajin M, Ardeleanu C, Pelmuş M: [Gastric stromal tumors--Clinical and histopathological analysis of four cases]. Chirurgia (Bucur); 2003 Sep-Oct;98(5):443-51
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  • [Title] [Gastric stromal tumors--Clinical and histopathological analysis of four cases].
  • BACKGROUND: The aim of this study is to present our experience concerning a rare form of gastric tumor--gastrointestinal stromal tumor (GIST).
  • METHODOLOGY: We reviewed data of four patients with gastric stromal tumors, which have been admitted in our department from 1998-2002.
  • During surgery we discovered proximal gastric tumors with 4, 5, 10 and 20 cm in largest diameter.
  • We performed excision of the whole tumor with a security limit of 2 cm or gastric resection (one case), without limphadenectomy.
  • One patient developed an anastomotic fistula with a good evolution under conservative treatment.
  • Histopathological and immunohistochemical study diagnosed gastric stromal tumors by identifying the CD 117 maker.
  • Postoperatively neither one of our patients received chemotherapy or radiotherapy.
  • The other two patients are in a good condition up to date, without metastasis, one and respectively three years after surgical treatment.
  • CONCLUSIOUS: Correct diagnosis, complete tumor resection and surveillance are essential steps in management of gastric stromal tumors.
  • [MeSH-major] Leiomyosarcoma / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Proto-Oncogene Proteins c-kit / analysis. Retrospective Studies. Stromal Cells / pathology. Treatment Outcome

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  • (PMID = 14999973.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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8. Matsutani T, Onda M, Miyashita M, Hao K, Yokoyama S, Matsuda T, Futami R, Takubo K, Sasajima K: Liver abscesses associated with stromal tumour of the stomach in a young woman. Eur J Gastroenterol Hepatol; 2001 Dec;13(12):1485-9
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  • [Title] Liver abscesses associated with stromal tumour of the stomach in a young woman.
  • She was found to have liver abscesses and a gastric submucosal mass by computed tomography and ultrasonography.
  • Gastroscopy and a barium swallow revealed a round submucosal mass with a giant ulceration in the body of the stomach.
  • Cultures of the fluid from a liver abscess and gastric juice yielded alpha-haemolytic streptococci.
  • The tumour was diagnosed as a stromal tumour of the stomach (leiomyosarcoma) in the final histological report.
  • The patient was discharged on postoperative day 17 without receiving adjuvant radio-chemotherapy.
  • This is a rare case of a liver abscess associated with a stromal tumour of the stomach in a young patient.
  • [MeSH-major] Leiomyosarcoma / complications. Liver Abscess / complications. Liver Abscess / microbiology. Stomach Neoplasms / complications
  • [MeSH-minor] Adult. Candida / isolation & purification. Disease-Free Survival. Female. Humans. Micrococcus / isolation & purification. Neisseria / isolation & purification. Streptococcus pyogenes / isolation & purification. Treatment Outcome

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  • (PMID = 11742198.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Thong-Ngam D, Tangkijvanich P, Mahachai V, Kullavanijaya P: Current status of gastric cancer in Thai patients. J Med Assoc Thai; 2001 Apr;84(4):475-82
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  • [Title] Current status of gastric cancer in Thai patients.
  • To determine the current status in various aspects of gastric cancer in Thai patients, we retrospectively reviewed the records of 119 patients with histologically proven gastric cancer in King Chulalongkorn Memorial Hospital during the five-year period from 1994 to 1998.
  • Lesion location was lower third in 40.3 per cent, middle third in 31.9 per cent, upper third in 15.1 per cent and entire stomach in 3.4 per cent of patients.
  • Adenocarcinoma was the most common histological finding (91.6%), followed by lymphoma and leiomyosarcoma (3.4% each).
  • Management was surgical treatment in 58.9 per cent (total gastrectomy 14.5%, subtotal gastrectomy 33.3% and palliative bypass surgery in 11.1%).
  • Systemic chemotherapy was the primary modality of therapy in 16.8 per cent and was adjuvant therapy in 18.5 per cent.
  • The median survival time of resectable cases was 1.00+/-0.53 years, significantly longer than that of unresectable cases (0.11+/-0.03 years) (p=0.0025).
  • However, the administration of chemotherapy did not improve the survival rate.
  • It is concluded that, in Thailand, gastric cancer continues to be an important health problem and is generally associated with a poor prognosis.
  • [MeSH-major] Stomach Neoplasms / epidemiology

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  • (PMID = 11460956.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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10. Maksimovic S: Double tract reconstruction after total gastrectomy in patients with gastric cancer: our experience. Med Arh; 2010;64(2):116-8
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  • [Title] Double tract reconstruction after total gastrectomy in patients with gastric cancer: our experience.
  • PURPOSE: Gastric cancer (GC) remains one of the most frequent cancers worldwide.
  • The double tract (DT) method is the optimal reconstruction procedure aftertotal gastrectomy for patients with gastric cancer.
  • Tumor diffused in the sections of stomach in 37 cases: cardia and body in 14 cases, body and antrum in 16 cases, and in only body of stomach in 7 cases.
  • In the pathological examination, the tumors of 34 patients were diagnosed as adenocarcinoma, 2 as malignant lymphoma, and i as leiomyosarcoma.
  • CONCLUSIONS: The benefits of this method are (1) a simple procedure;.
  • [MeSH-major] Digestive System Surgical Procedures. Gastrectomy / rehabilitation. Stomach Neoplasms / surgery

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  • (PMID = 20514781.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bosnia and Herzegovina
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11. Jadvar H, Tatlidil R, Garcia AA, Conti PS: Evaluation of recurrent gastric malignancy with [F-18]-FDG positron emission tomography. Clin Radiol; 2003 Mar;58(3):215-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of recurrent gastric malignancy with [F-18]-FDG positron emission tomography.
  • AIM: We retrospectively assessed the use of [(18)F] fluorodeoxyglucose positron emission tomography (FDG PET) in the evaluation of recurrent disease in patients with history of gastric malignancy.
  • MATERIALS AND METHODS: Eighteen patients were referred for FDG PET for evaluation of recurrent gastric cancer.
  • Prior treatments included total (n = 4) or partial gastrectomy (n = 14) followed by chemotherapy alone (n = 7) or combined chemoradiation therapy (n = 2).
  • The interval between the most recent treatment and PET ranged from 3 months to 2 years.
  • RESULTS: PET was concordant with computed tomography (CT) in 12 patients (5 TP, 6 TN, 1 FN).
  • Additional chemotherapy was initiated in these three patients (17% of total) based on PET localization of disease.
  • PET and a gastric anastomosis biopsy were negative in another patient with positive CT.
  • CONCLUSION: FDG PET may be useful in the evaluation of recurrent gastric cancer, and can localize the disease when CT is non-diagnostic.
  • Imaging evaluation with PET may also impact on the clinical management of patients with recurrent gastric cancer.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Fluorodeoxyglucose F18. Leiomyosarcoma / radionuclide imaging. Neoplasm Recurrence, Local / radionuclide imaging. Radiopharmaceuticals. Stomach Neoplasms / radionuclide imaging
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies. Tomography, Emission-Computed / methods. Tomography, X-Ray Computed / methods

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  • [Copyright] Copyright 2003 The Royal College of Radiologists
  • [ErratumIn] Clin Radiol. 2003 Jul;58(7):570
  • (PMID = 12639527.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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12. Kikuchi H, Konn H, Kamiya K, Baba M, Ohta M, Kondo K, Hiramatsu Y, Yamamoto M, Tanaka T, Sugimura H, Ohashi M, Kanda T, Nakamura S: [Two cases of postoperative recurrence of gastric GIST treated by imatinib]. Gan To Kagaku Ryoho; 2004 Oct;31(10):1569-73
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  • [Title] [Two cases of postoperative recurrence of gastric GIST treated by imatinib].
  • Case 1: This 63-year-old Japanese man received a partial gastrectomy for leiomyosarcoma in 1993.
  • Though the response to treatment was SD-PR initially, a CT scan 15 months after initial treatment demonstrated the regrowth of the tumor in his liver.
  • The response to treatment was SD, and continued for 12 months.
  • IM is the treatment of choice for unresectable recurrence of GIST.
  • Both basic and clinical research is necessary to increase the therapeutic efficacy of IM.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Gastrectomy. Gastrointestinal Neoplasms / drug therapy. Leiomyosarcoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Benzamides. Combined Modality Therapy. Drug Administration Schedule. Female. Humans. Imatinib Mesylate. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Middle Aged. Protein-Tyrosine Kinases / antagonists & inhibitors. Thyroid Neoplasms / secondary

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  • (PMID = 15508453.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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13. Rogiers X, Brunken C: Surgical management of hepatic metastatic disease. Saudi Med J; 2000 Jun;21(6):519-22
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  • Radical surgical resection, if possible, is the treatment of choice.
  • Radical resection of metastases from wilms-tumor, carcinoids, carcinoma of the breast, hypernephroma, adrenal tumors, malignant melanoma, leiomyosarcoma and gastric cancer may improve long time survival, however knowledge is too small for giving general directions.
  • Local destructive therapies are only beneficial when a total necrosis of the tumor is reached.
  • Indications for this treatment are quite rare.
  • Both, systemic and local chemotherapy offers only palliation with little influence on long time survival.
  • Adjuvant and neo-adjuvant chemotherapy is applicated under study conditions with encouraging results.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Colorectal Neoplasms / pathology. Europe / epidemiology. Humans. Patient Selection. Proportional Hazards Models. Radiotherapy, Adjuvant. Survival Analysis. Treatment Outcome

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  • (PMID = 11508246.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Saudi Arabia
  • [Number-of-references] 17
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14. Donthireddy KR, Ailawadhi S, Nasser E, Schiff MD, Nwogu CE, Nava HR, Javle MM: Malignant gastroparesis: pathogenesis and management of an underrecognized disorder. J Support Oncol; 2007 Sep;5(8):355-63
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  • [Title] Malignant gastroparesis: pathogenesis and management of an underrecognized disorder.
  • Gastroparesis is a disorder of the stomach caused by delayed gastric emptying in the absence of mechanical obstruction.
  • Gastroparesis has been described as a complication of several malignancies, including gastric, pancreatic, gallbladder, esophageal, and lung cancers, as well as leiomyosarcoma.
  • In the setting of malignancy, gastroparesis may result from the cancer itself or may be a complication of its treatment with such modalities as surgery, radiation therapy, or chemotherapy.
  • Appropriate treatment of MG may help to avoid serious consequences, such as cancer cachexia, intolerance of oral anticancer agents, dehydration, and hospitalization.
  • [MeSH-major] Gastric Emptying. Gastrointestinal Agents / therapeutic use. Gastrointestinal Motility / drug effects. Gastroparesis / etiology. Neoplasms / complications
  • [MeSH-minor] Cathartics / therapeutic use. Humans. Prognosis. Risk Factors

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  • [CommentIn] J Support Oncol. 2007 Sep;5(8):368-70 [17944145.001]
  • [CommentIn] J Support Oncol. 2007 Sep;5(8):366-7 [17944144.001]
  • (PMID = 17944143.001).
  • [ISSN] 1544-6794
  • [Journal-full-title] The journal of supportive oncology
  • [ISO-abbreviation] J Support Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cathartics; 0 / Gastrointestinal Agents
  • [Number-of-references] 52
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15. Horenstein MG, Hitchcock TA, Tucker JA: Dual CD117 expression in gastrointestinal stromal tumor (GIST) and paraganglioma of Carney triad: a case report. Int J Surg Pathol; 2005 Jan;13(1):87-92
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  • We report a 36-year-old white woman with complete Carney triad, including metastatic gastric stromal tumor (GIST), pulmonary chondroma, and nonfunctioning extra-adrenal paraganglioma.
  • [MeSH-major] Chondroma / pathology. Gastrointestinal Stromal Tumors / pathology. Leiomyosarcoma / secondary. Lung Neoplasms / pathology. Paraganglioma, Extra-Adrenal / pathology. Proto-Oncogene Proteins c-kit / analysis
  • [MeSH-minor] Adult. Antigens, CD34 / analysis. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Chromogranins / analysis. Drug Therapy. Female. Humans. Palliative Care. Syndrome

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  • (PMID = 15735861.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Chromogranins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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16. Senderowicz AM: Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies. Leukemia; 2001 Jan;15(1):1-9
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  • [Title] Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.
  • Initial clinical trials with infusional flavopiridol demonstrated activity in some patients with non-Hodgkin's lymphoma, renal, prostate, colon and gastric carcinomas.
  • The first clinical trial of UCN-01 demonstrated very prolonged half-life (approximately 600 h), 100 times longer than the half-life observed in preclinical models.
  • Clinical activity was observed in patients with melanoma, non-Hodgkin's lymphoma and leiomyosarcoma.
  • Of interest, a patient with anaplastic large cell lymphoma refractory to high-dose chemotherapy showed no evidence of disease after 3 years of UCN-01 therapy.
  • Although important questions remain to be answered, these positive experiences will hopefully increase the therapeutic modalities in hematological malignancies.
  • [MeSH-major] Alkaloids / pharmacology. Cyclin-Dependent Kinases / antagonists & inhibitors. Enzyme Inhibitors / pharmacology. Flavonoids / pharmacology. Hematologic Neoplasms / drug therapy. Piperidines / pharmacology
  • [MeSH-minor] Cell Cycle / drug effects. Clinical Trials as Topic. Humans. Retinoblastoma Protein / metabolism. Signal Transduction / drug effects. Staurosporine / analogs & derivatives

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  • (PMID = 11243375.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Enzyme Inhibitors; 0 / Flavonoids; 0 / Piperidines; 0 / Retinoblastoma Protein; 45AD6X575G / alvocidib; 7BU5H4V94A / 7-hydroxystaurosporine; EC 2.7.11.22 / Cyclin-Dependent Kinases; H88EPA0A3N / Staurosporine
  • [Number-of-references] 100
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17. Twelves C, Hoekman K, Bowman A, Vermorken JB, Anthoney A, Smyth J, van Kesteren C, Beijnen JH, Uiters J, Wanders J, Gomez J, Guzmán C, Jimeno J, Hanauske A: Phase I and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours. Eur J Cancer; 2003 Sep;39(13):1842-51
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  • One pCR (melanoma), CR (uterine leiomyosarcoma), one PR (colon stromal sarcoma) and a MR (37% tumour shrinkage, gastric stromal sarcoma) were observed.
  • A further 9 patients with colorectal, mesothelioma, bile duct carcinoma and bladder cancer had SD which lasted for six or more treatment cycles.
  • [MeSH-major] Antineoplastic Agents, Alkylating / pharmacokinetics. Dioxoles / pharmacokinetics. Isoquinolines / pharmacokinetics. Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Cohort Studies. Dose-Response Relationship, Drug. Female. Hematologic Diseases / chemically induced. Humans. Infusions, Intravenous. Male. Maximum Tolerated Dose. Middle Aged. Tetrahydroisoquinolines

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  • (PMID = 12932661.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Dioxoles; 0 / Isoquinolines; 0 / Tetrahydroisoquinolines; 114899-77-3 / trabectedin
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