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Items 1 to 29 of about 29
1. Stefanowicz J, Izycka-Swieszewska E, Drozyńska E, Pienczk J, Połczyńska K, Czauderna P, Sierota D, Bień E, Stachowicz-Stencel T, Kosiak W, Balcerska A: Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics. Folia Neuropathol; 2008;46(3):176-85
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  • In two of the children the onset of neurological symptoms was connected with a vaccination and in one with viral infection.
  • All cases were in stage II or III of the disease, with no metastases or MYCN amplification.
  • The group included two ganglioneuroblastomas, one ganglioneuroma and one differentiating neuroblastoma.
  • Immunohistochemical analysis of inflammatory infiltrations revealed mixed type populations of lymphocytes with prevalence of the cytotoxic type (CD8 and CD56-positive cells).
  • All patients were treated by surgery alone or with adjuvant chemotherapy with a positive outcome.


2. Santos A, Calvet L, Terrier-Lacombe MJ, Larsen A, Bénard J, Pondarré C, Aubert G, Morizet J, Lavelle F, Vassal G: In vivo treatment with CPT-11 leads to differentiation of neuroblastoma xenografts and topoisomerase I alterations. Cancer Res; 2004 May 1;64(9):3223-9
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  • [Title] In vivo treatment with CPT-11 leads to differentiation of neuroblastoma xenografts and topoisomerase I alterations.
  • Topoisomerase I inhibitors, such as CPT-11, are potent anticancer drugs against neuroblastoma (NB).
  • Prolonged stable disease was observed, resulting in an overall tumor growth delay of 115 days.
  • During treatment, tumors differentiated into ganglioneuroblastomas (GGNB), which reverted into an immature phenotype when treatment was discontinued.
  • The full-length Mr 100,000 topo I protein was present in both pre and post-treatment immature NB xenografts.
  • [MeSH-major] Camptothecin / analogs & derivatives. Camptothecin / pharmacology. Enzyme Inhibitors / pharmacology. Neuroblastoma / drug therapy. Neuroblastoma / enzymology. Topoisomerase I Inhibitors
  • [MeSH-minor] Animals. Antineoplastic Agents, Phytogenic / pharmacology. Cell Differentiation / drug effects. Cell Division / drug effects. Child. Child, Preschool. DNA Topoisomerases, Type I / metabolism. Female. Humans. Infant. Infant, Newborn. Male. Mice. Mice, Nude. Retinaldehyde / pharmacology. Xenograft Model Antitumor Assays

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  • (PMID = 15126363.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Enzyme Inhibitors; 0 / Topoisomerase I Inhibitors; 472-86-6 / 13-cis-retinal; 7673326042 / irinotecan; EC 5.99.1.2 / DNA Topoisomerases, Type I; RR725D715M / Retinaldehyde; XT3Z54Z28A / Camptothecin
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3. Kanakaraj G, Zamzuri I, Abdullah J, Mohd Ghazali M, Mahamood Z, Shafiee A, Madhavan M, Rahman MT: Extradural spinal cord and intraabdominal ganglioneuroblastoma. Med J Malaysia; 2005 Dec;60(5):663-6

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  • [Title] Extradural spinal cord and intraabdominal ganglioneuroblastoma.
  • We report a rare case of a giant extradural and intraabdominal ganglioneuroblastoma in a young Malay girl who presented to a paediatrician initially at 5 days of life with a palpable abdominal mass.
  • She subsequently underwent vascular embolisation followed by the removal of this large tumour both via the abdomen and through a laminectomy approach and subsequently refused chemotherapy.
  • [MeSH-major] Abdominal Neoplasms / pathology. Ganglioneuroblastoma / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 16515125.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Malaysia
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4. Lara-Bohórquez C, González-Cámpora R, Mendoza-García E, Ríos-Martín JJ, Pareja-Megía MJ, López-Beltrán A: TP53, BCL-2, p21Waf1/Cip1 and metallothionein as markers of differentiation, response to treatment and prognosis in neuroblastic tumors. Anal Quant Cytol Histol; 2008 Apr;30(2):105-12
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  • [Title] TP53, BCL-2, p21Waf1/Cip1 and metallothionein as markers of differentiation, response to treatment and prognosis in neuroblastic tumors.
  • OBJECTIVE: To identify markers of response to therapy in neuroblastic tumors.
  • STUDY DESIGN: A total of 58 patients with neuroblastic tumor (38 neuroblastomas, 13 ganglioneuroblastomas and 7 ganglioneuromas) were included in the study.
  • TP53, BCL-2, p21Waf1/Cip1 and metallothionein were included as a biologic approach to tumor differentiation, response to therapy and prognosis.
  • RESULTS: Patients who died of disease had the following immunophenotype: BCL-2 (9 of 10), nuclear TP53 (7 of 10) and metallothionein (7 of 10).
  • TP-53 expression was related to clinical stage (p = 0.062) and disease outcome (p = 0.0218).
  • All patients in whom treatment failed expressed metallothionein (3 of 3).
  • CONCLUSION: TP53, BCL-2, p21Waf1/Cip1 and metallothionein had limited value reflecting tumor maturation (differentiation) or predicting response to therapy.

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  • (PMID = 18561747.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 9038-94-2 / Metallothionein
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5. Sabatino G, Lauriola L, Sioletic S, Puca A: Occipital ganglio-neuroblastoma in an adult. Acta Neurochir (Wien); 2009 May;151(5):495-6
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  • [Title] Occipital ganglio-neuroblastoma in an adult.
  • INTRODUCTION: Ganglioneuroblastomas (GNBs) are embryonic neoplasms, whose behaviour are not well established; 80% of cases occur in the first decade, while only two cases in the adulthood had been reported.
  • CLINICAL REPORT: This 60-year-old female presented with a 2-month history of headache, vertigo, amnesia.
  • A diagnosis of GNB was made from histopathological examination and immunohistochemistry.
  • She underwent fractioned radiotherapy (60 Gy) and chemotherapy with Temozolomide.
  • She remained disease free 18 months after diagnosis.
  • DISCUSSION: Recent observations suggest that in spite of an embryonal appearance, these tumours are circumscribed and have a better prognosis than malignant gliomas.
  • [MeSH-major] Brain Neoplasms / diagnosis. Ganglioneuroblastoma / diagnosis. Neoplasms, Second Primary / diagnosis. Occipital Lobe / radiography

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  • (PMID = 19262982.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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6. Miyauchi J, Kiyotani C, Shioda Y, Kumagai M, Honna T, Matsuoka K, Masaki H, Aiba M, Hata J, Tsunematsu Y: Unusual chromaffin cell differentiation of a neuroblastoma after chemotherapy and radiotherapy: report of an autopsy case with immunohistochemical evaluations. Am J Surg Pathol; 2004 Apr;28(4):548-53
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  • [Title] Unusual chromaffin cell differentiation of a neuroblastoma after chemotherapy and radiotherapy: report of an autopsy case with immunohistochemical evaluations.
  • Ganglionic neuronal differentiation of childhood neuroblastoma is seen with increasing age, leading to more differentiated tumors called ganglioneuroblastomas or ganglioneuromas.
  • Tumor cells with a chromaffin-cell nature have only been detected using histochemical techniques in neuroblastoma cell lines or focal areas of certain in vivo tumors.
  • We describe a neuroblastoma that exhibited an unusual differentiation toward chromaffin cells in a patient that had been treated with surgery, intensive chemotherapy, and radiotherapy.
  • Although a biopsy specimen of the retroperitoneal primary tumor was extensively necrotic, possibly because of a previous chemotherapy regimen, surgically resected metastatic tumors of bilateral ovaries were viable and diagnosed as poorly differentiated neuroblastomas according to the International Neuroblastoma Pathology Classification system.
  • However, metastatic tumors of bilateral lungs examined at the time of autopsy exhibited histologic features similar to those of a pheochromocytoma/paraganglioma, and immunohistochemical examinations demonstrated that these tumors were composed of extra-adrenal chromaffin cells.
  • [MeSH-minor] Cell Differentiation. Child, Preschool. Combined Modality Therapy. Fatal Outcome. Female. Humans. Immunohistochemistry. Ovarian Neoplasms / secondary

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  • (PMID = 15087676.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Kitauchi T, Kagebayashi Y, Hosokawa Y, Otani T, Yoshida K, Ohzono S, Hirao Y, Matsumoto K, Okumura H: [A case of long-term survival neuroblastoma with conservative therapy]. Hinyokika Kiyo; 2002 Feb;48(2):71-3
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  • [Title] [A case of long-term survival neuroblastoma with conservative therapy].
  • We report a case of long-term survival in a patient with neuroblastoma treated with conservative therapy.
  • A 2-year-old female patient who presented with a lower abdominal mass was diagnosed with neuroblastoma.
  • Histopathological diagnosis of para-aortic lymph node was ganglioneuroblastoma.
  • Postoperatively 50 Gy-radiation and chemotherapy were performed.
  • At age 17, needle biopsy of the tumor was performed, and the histopathological diagnosis was ganglioneuroma.
  • [MeSH-major] Abdominal Neoplasms / therapy. Neuroblastoma / therapy
  • [MeSH-minor] Adolescent. Combined Modality Therapy. Female. Ganglioneuroblastoma / pathology. Humans. Hydronephrosis / complications. Hydronephrosis / surgery. Survivors

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  • (PMID = 11968730.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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8. Hussein HA, Goda HA: Paravertebral neurogenic tumors with intraspinal extension: preoperative evaluation and surgical approach. J Egypt Natl Canc Inst; 2009 Mar;21(1):12-22

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  • Benign schwannoma were diagnosed in 5 cases, malignant schwannoma in 3, neurofibromatosis in one case, neuroblastoma in 3 cases, ganglioneuroblastoma in 2 cases and ganglioneuroma in 2 cases.
  • C-T guided biopsy can select patients with pathological diagnosis that could be sensitive to pre operative chemotherapy and/or radiotherapy to facilitate surgery.

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  • (PMID = 20601967.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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9. Duhem-Tonnelle V, Vinchon M, Defachelles AS, Cotten A, Dhellemmes P: Mature neuroblastic tumors with spinal cord compression: report of five pediatric cases. Childs Nerv Syst; 2006 May;22(5):500-5
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  • Whereas neuroblastomas (NB) are relatively common and are generally treated with chemotherapy, mature neuroblastic tumors (MNT), which include intermixed ganglioneuroblastomas (iGNB) and ganglioneuromas (GN), are less common and the role of surgery is more prominent.
  • The neurological and oncological outcomes were generally favorable after surgical resection, followed by orthotic treatment.
  • In one case with neurofibromatosis type 1, the tumor was inoperable and the child died of tumor progression several years later.
  • In case of subtotal removal, tumor remnants can stay stable without oncological treatment.

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  • (PMID = 16369850.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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10. Spugnini EP, Citro G, Dotsinsky I, Mudrov N, Mellone P, Baldi A: Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy. Vet J; 2008 Nov;178(2):291-3
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  • [Title] Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy.
  • A diagnosis of ganglioneuroblastoma was suggested by the tumour appearance following histopathological staining with haematoxylin and eosin and haematoxylin/van Gieson.
  • Immunohistochemical staining for glial fibrillary acidic protein (GFAP), vimentin, neuron-specific enolase (NSE), neurofilament and S100 further confirmed the diagnosis.
  • The tumour had completely regressed within 1 week of the third ECT application and remained in remission for 402 days at which time a small recurrence was noted.
  • Electrochemotherapy is considered a safe and effective treatment for localised neoplasms of cats and dogs and warrants further investigation.
  • [MeSH-major] Cat Diseases / drug therapy. Electrochemotherapy / veterinary. Ganglioneuroblastoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Cats. Male

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  • (PMID = 17910926.001).
  • [ISSN] 1090-0233
  • [Journal-full-title] Veterinary journal (London, England : 1997)
  • [ISO-abbreviation] Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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11. Johnson TE, Toledano SR: Ganglioneuroblastoma metastatic to the orbit. Ophthal Plast Reconstr Surg; 2003 Jul;19(4):330-3
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  • [Title] Ganglioneuroblastoma metastatic to the orbit.
  • A 10-month-old girl presented with an extensive orbital and cranial metastatic lesion from an adrenal ganglioneuroblastoma.
  • Treatment with chemotherapy alone resulted in complete regression of the tumors with over 7 years of follow-up.
  • Good prognostic indicators included her young age at diagnosis, DNA index of tumor cells of 1.4, and the histologic subtype of neuroblastic tumor.
  • This is the first reported case of ganglioneuroblastoma metastatic to the orbit.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Ganglioneuroblastoma / secondary. Orbital Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Female. Humans. Infant. Nerve Tissue Proteins / analysis. Skull Neoplasms / diagnosis. Skull Neoplasms / drug therapy. Skull Neoplasms / secondary

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  • (PMID = 12878887.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Nerve Tissue Proteins
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12. Averbuch D, Boekhoutt T, Falk R, Engelhard D, Shapiro M, Block C, Polacheck I: Fungemia in a cancer patient caused by fluconazole-resistant Cryptococcus laurentii. Med Mycol; 2002 Oct;40(5):479-84
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  • We report the recent isolation of Cryptococcus laurentii from the blood of a patient given the diagnosis of ganglioneuroblastoma.
  • Repeated recovery of the organism from different blood cultures, and the patient's good response to treatment with amphotericin B support its etiological role. C. laurentii has rarely been implicated as a cause of clinically significant infections.
  • The identity of reported isolates has not always been adequately documented, and some appear to have been isolated from lesions caused by Cryptococcus neoformans, emphasizing the true rarity of disease due to this fungus.
  • [MeSH-major] Antifungal Agents / pharmacology. Cryptococcus / isolation & purification. Fluconazole / pharmacology. Fungemia / etiology. Ganglioneuroblastoma / complications
  • [MeSH-minor] Adolescent. Cryptococcosis / drug therapy. Cryptococcosis / etiology. Drug Resistance, Fungal. Humans. Male. Microbial Sensitivity Tests. Phylogeny

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  • (PMID = 12462527.001).
  • [ISSN] 1369-3786
  • [Journal-full-title] Medical mycology
  • [ISO-abbreviation] Med. Mycol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifungal Agents; 8VZV102JFY / Fluconazole
  • [Number-of-references] 31
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13. Ito A, Uno T, Gunji Y, Yamauchi T, Egami S, Kawarasaki H, Momoi MY: Obstructive jaundice as a presentation of ganglioneuroblastoma. J Pediatr Hematol Oncol; 2005 Feb;27(2):112-4
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  • [Title] Obstructive jaundice as a presentation of ganglioneuroblastoma.
  • Seven cases of obstructive jaundice caused by neuroblastoma have been reported, and only three of these patients had the symptom at the onset of the disease.
  • The authors report a case of ganglioneuroblastoma presenting with obstructive jaundice as a rare initial feature.
  • After the histologic diagnosis with open biopsy, chemotherapy consisting of cisplatin, pirarubicin hydrochloride/doxorubicin, cyclophosphamide, and vincristine was given.
  • The treatment resulted in reduction in the tumor size and relief of the obstructive jaundice.
  • Complete resection of the tumor was possible after five courses of chemotherapy.
  • [MeSH-major] Doxorubicin / analogs & derivatives. Ganglioneuroblastoma / complications. Jaundice, Obstructive / etiology. Retroperitoneal Neoplasms / complications
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Child, Preschool. Cisplatin / administration & dosage. Cyclophosphamide / administration & dosage. Humans. Male. Vincristine / administration & dosage

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  • (PMID = 15701990.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; D58G680W0G / pirarubicin; Q20Q21Q62J / Cisplatin
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14. Lonergan GJ, Schwab CM, Suarez ES, Carlson CL: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics; 2002 Jul-Aug;22(4):911-34
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  • [Title] Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
  • Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma are tumors of the sympathetic nervous system that arise from primitive sympathogonia and are referred to collectively as neuroblastic tumors.
  • They arise wherever sympathetic tissue exists and may be seen in the neck, posterior mediastinum, adrenal gland, retroperitoneum, and pelvis.
  • Ganglioneuroblastoma is composed of both mature gangliocytes and immature neuroblasts and has intermediate malignant potential.
  • Neuroblastoma is the most immature, undifferentiated, and malignant tumor of the three.
  • Treatment consists of surgery and, usually, chemotherapy.
  • Despite recent advances in treatment, including bone marrow transplantation, neuroblastoma remains a relatively lethal tumor, accounting for 10% of pediatric cancers but 15% of cancer deaths in children.
  • [MeSH-minor] Ganglioneuroblastoma / pathology. Ganglioneuroblastoma / radiography. Humans. Magnetic Resonance Imaging. Neoplasm Staging. Prognosis. Risk Factors. Tomography, X-Ray Computed

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  • [Copyright] Copyright RSNA, 2002
  • (PMID = 12110723.001).
  • [ISSN] 0271-5333
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 123
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15. Moukheiber AK, Nicollas R, Roman S, Coze C, Triglia JM: Primary pediatric neuroblastic tumors of the neck. Int J Pediatr Otorhinolaryngol; 2001 Aug 20;60(2):155-61
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  • The histological diagnosis was ganglioneuroblastoma in three cases and neuroblastoma in one case.
  • Cervical computed tomography scan and/or magnetic resonance imaging depicted calcifications within the tumor in 50% of cases and allowed accurate assessment of extension.
  • Surgical treatment was performed in all patients.
  • Neoadjuvant chemotherapy was performed in one case.
  • No evidence of recurrence has been observed with a mean follow-up period of 7 years.
  • [MeSH-major] Ganglioneuroblastoma / diagnosis. Ganglioneuroma / diagnosis. Head and Neck Neoplasms / diagnosis. Neuroblastoma / diagnosis
  • [MeSH-minor] Biopsy, Needle. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Male. Radionuclide Imaging / methods. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 11518594.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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16. Zangeneh F, Young WF Jr, Lloyd RV, Chiang M, Kurczynski E, Zangeneh F: Cushing's syndrome due to ectopic production of corticotropin-releasing hormone in an infant with ganglioneuroblastoma. Endocr Pract; 2003 Sep-Oct;9(5):394-9
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  • [Title] Cushing's syndrome due to ectopic production of corticotropin-releasing hormone in an infant with ganglioneuroblastoma.
  • OBJECTIVE: To report the first recognized case of Cushing's syndrome due to a corticotropin-releasing hormone (CRH)-secreting ganglioneuroblastoma, which was found in an 18-month-old boy with hypertensive encephalopathy.
  • RESULTS: An 18-month-old boy with a history of recent weight gain was admitted because of sudden onset of right fixed esotropia and left facial palsy after episodes of emesis.
  • Despite discordant dynamic endocrine testing and negative somatostatin receptor scintigraphy, computed tomography showed a right 3.6- by 3.0-cm extra-adrenal retroperitoneal mass with central calcification extending 7 cm cephalocaudally.
  • The patient underwent exploratory laparotomy, followed by chemotherapy.
  • Findings on light microscopic and immunohistochemical examination of the retroperitoneal mass were consistent with a ganglioneuroblastoma that expressed CRH, pro-opiomelanocortin, and ACTH.
  • In this case, it was due to ectopic production of CRH by a ganglioneuroblastoma.
  • [MeSH-major] Corticotropin-Releasing Hormone / metabolism. Cushing Syndrome / etiology. Ganglioneuroblastoma / complications. Retroperitoneal Neoplasms / complications
  • [MeSH-minor] Humans. Immunohistochemistry. Infant. Male. Tomography, X-Ray Computed

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  • (PMID = 14583423.001).
  • [ISSN] 1530-891X
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9015-71-8 / Corticotropin-Releasing Hormone
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17. Schiavetti A, Ingrosso A, Picone S, Boscherini B: Growth hormone deficiency after localized ganglioneuroblastoma: A case report. J Pediatr Hematol Oncol; 2006 Sep;28(9):625-6
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  • [Title] Growth hormone deficiency after localized ganglioneuroblastoma: A case report.
  • Growth hormone deficiency (GHD) related to standard dose chemotherapy has rarely been described.
  • We report on a case of localized ganglioneuroblastoma treated by carboplatin/etoposide for 2 courses and surgery, which developed a serious GHD after 56 months.
  • At present, the child is growing on by GH replacement therapy.
  • We discuss about the hypothesis that GHD may be related to chemotherapy and we report a review of previous published cases.
  • [MeSH-major] Adrenal Gland Neoplasms / drug therapy. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Ganglioneuroblastoma / drug therapy. Growth Hormone / deficiency
  • [MeSH-minor] Body Height / drug effects. Carboplatin / adverse effects. Etoposide / adverse effects. Humans. Hypothalamus / drug effects. Hypothalamus / pathology. Infant. Male. Pituitary Gland / drug effects. Pituitary Gland / pathology

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  • (PMID = 17006271.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 9002-72-6 / Growth Hormone; BG3F62OND5 / Carboplatin
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18. Mizuno S, Iida T, Fujita S: Adult-onset adrenal ganglioneuroblastoma - Bone metastasis two years after surgery: report of a case. Surg Today; 2010 May;40(5):482-6
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  • [Title] Adult-onset adrenal ganglioneuroblastoma - Bone metastasis two years after surgery: report of a case.
  • Ganglioneuroblastoma (GNB) is a common type of tumor in children but is rarely seen in adults.
  • Histologically, on gross examination the tumor contained a visible neuroblastomatous nodule with ganglioneuromatous component, and was diagnosed as GNB nodular classical type.
  • Because the prognosis was not favorable, despite surgery and radiation therapy or chemotherapy, it is necessary to closely follow patients with large GNB tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / surgery. Ganglioneuroblastoma / pathology. Ganglioneuroblastoma / surgery. Lumbar Vertebrae / pathology. Spinal Neoplasms / secondary

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  • [Cites] Int Urol Nephrol. 2004;36(4):481-3 [15787320.001]
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  • (PMID = 20425556.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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19. Tang KT, Lee HC, Liang DC, Chen SH, Liu HC, Sheu JC: Neural-crest tumor presenting with chronic diarrhea: a report of three cases. J Formos Med Assoc; 2002 Dec;101(12):864-7
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  • These patients (two girls and one boy aged between 15 to 28 mo) presented with a 3-week to 6-month history of chronic diarrhea of unknown cause.
  • A posterior mediastinal mass or abdominal mass found on sonography and chest roentgenography eventually led to the diagnosis of neural-crest tumor in these patients.
  • Pathology revealed ganglioneuroblastoma in two cases and neuroblastoma in one.
  • All three patients received chemotherapy and underwent surgery.
  • Although one of the patients died of septic shock during chemotherapy, the other two remained free of disease at 30 and 22 months of postoperative follow-up, respectively.


20. Blokker RS, Smit LM, van den Bos C, Overberg PC, Caron HN, Kaspers GJ: [A boy with acute cerebellar ataxia without opsoclonus caused by neuroblastoma]. Ned Tijdschr Geneeskd; 2006 Apr 8;150(14):799-803
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  • [Transliterated title] Een jongen met acute cerebellaire ataxie zonder opsoclonus, door een neuroblastoom.
  • Treatment with a curative intent was successful and consisted of metaiodobenzylguanidine I 131, chemotherapy, tumour resection, chemotherapy again and follow-up treatment with isotretinoin after irradiation.
  • The mean time between initial presentation and diagnosis ofneuroblastoma or ganglioneuroblastoma was 12 months.
  • [MeSH-minor] Acute Disease. Child, Preschool. Humans. Male. Ocular Motility Disorders / epidemiology

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  • (PMID = 16649400.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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21. Corapcioglu F, Mutlu H, Kara B, Inan N, Akansel G, Gürbüz Y, Topcu S: Response to rituximab and prednisolone for opsoclonus-myoclonus-ataxia syndrome in a child with ganglioneuroblastoma. Pediatr Hematol Oncol; 2008 Dec;25(8):756-61
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  • [Title] Response to rituximab and prednisolone for opsoclonus-myoclonus-ataxia syndrome in a child with ganglioneuroblastoma.
  • The neurologic symptoms are generally treated with a number of immunosupressive and immunomodulating agents.
  • He had a diagnosis of ganglionueroblastoma at the thoracal paraspinal region.
  • Rituximab therapy was started and continued for total 8 weeks without any side effect.
  • The authors observed excellent neurologic response in the patient at the 4th week of treatment.
  • Rituximab is a new, promising, and safe therapy for OMA syndrome in children with neuroblastoma.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Ganglioneuroblastoma / drug therapy. Opsoclonus-Myoclonus Syndrome / drug therapy. Prednisolone / therapeutic use


22. De Moerloose B: [The prognostic significance of P-glycoprotein in children with acute lymphoblastic leukemia and neuroblastoma]. Verh K Acad Geneeskd Belg; 2005;67(1):45-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • P-glycoprotein (P-gp), a pump located in the cell membrane, extrudes several clinically important drugs from the cell, and hence causes multidrug resistance (MDR).
  • Children scoring positive had a significantly worse outcome than those with a negative test result.
  • In neuroblastoma, ganglioneuroblastoma and ganglioneuroma, P-gp is detected by different assays: immunocytochemistry, flow cytometric immunological and functional tests and an in vivo imaging technique using 99mTc sestamibi.
  • P-gp was found more frequently in low-stage neuroblastoma, differentiated tumours and tumours after chemotherapy.
  • [MeSH-major] Neuroblastoma / drug therapy. P-Glycoprotein / physiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • [MeSH-minor] Child. Drug Resistance, Multiple / genetics. Drug Resistance, Neoplasm. Flow Cytometry. Humans. Immunohistochemistry / methods. Predictive Value of Tests. Prognosis. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 15828306.001).
  • [ISSN] 0302-6469
  • [Journal-full-title] Verhandelingen - Koninklijke Academie voor Geneeskunde van België
  • [ISO-abbreviation] Verh. K. Acad. Geneeskd. Belg.
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / P-Glycoprotein
  • [Number-of-references] 19
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23. Rohrer T, Trachsel D, Engelcke G, Hammer J: Congenital central hypoventilation syndrome associated with Hirschsprung's disease and neuroblastoma: case of multiple neurocristopathies. Pediatr Pulmonol; 2002 Jan;33(1):71-6
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  • [Title] Congenital central hypoventilation syndrome associated with Hirschsprung's disease and neuroblastoma: case of multiple neurocristopathies.
  • We report on a male infant with the rare combined occurrence of congenital central hypoventilation syndrome (CCHS or Ondine's curse), Hirschsprung's disease (HD), and neuroblastoma.
  • We initiated an attempt at curative chemotherapy.
  • We emphasize the importance of screening CCHS patients for associated illnesses such as neuroblastoma and ganglioneuroblastoma at time of diagnosis.
  • [MeSH-major] Abdominal Neoplasms / complications. Hirschsprung Disease / complications. Neuroblastoma / complications. Sleep Apnea, Central / complications


24. Kang CH, Kim YT, Jeon SH, Sung SW, Kim JH: Surgical treatment of malignant mediastinal neurogenic tumors in children. Eur J Cardiothorac Surg; 2007 Apr;31(4):725-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of malignant mediastinal neurogenic tumors in children.
  • INTRODUCTION: The aim of this study was to identify the role of surgical resection in the treatment of malignant mediastinal neurogenic tumors in children.
  • MATERIALS AND METHODS: Thirty-eight consecutive children, who underwent surgical resection of a malignant mediastinal neurogenic tumor between 1986 and 2004, were included in this study.
  • The tumor cell types were neuroblastoma in 23 patients (60.5%), ganglioneuroblastoma in 14 (36.8%), and malignant neuroepithelioma in 1 (2.6%).
  • Surgery was performed for curative resection in localized tumors and salvage resection of residual mediastinal masses after chemotherapy in stage IV tumors.
  • Of the 16 patients (42.1%) who underwent salvage resection, 14 had neuroblastoma and 2 ganglioneuroblastoma.
  • CONCLUSIONS: Surgical resection of localized malignant mediastinal neurogenic tumor in children showed good long-term survival, and salvage operations after chemotherapy showed acceptable long-term survival.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Ganglioneuroblastoma / mortality. Ganglioneuroblastoma / surgery. Humans. Infant. Infant, Newborn. Male. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Staging. Neuroblastoma / mortality. Neuroblastoma / surgery. Postoperative Complications. Preoperative Care / methods. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 17306984.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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25. Ravindra S, Kini U: Cytomorphology and morphometry of small round-cell tumors in the region of the kidney. Diagn Cytopathol; 2005 Apr;32(4):211-6
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  • Small round-cell tumors (SRCTs), with malignant cell components measuring 10 m or less in diameter with scanty cytoplasm in alcohol-fixed smears, pose a diagnostic challenge at fine-needle aspiration cytology (FNAC), especially when they are situated in and around the kidney and need facilities such as electron microscopy, immunohistochemistry, tissue culture, and cytogenetics for their subtyping.
  • A precise cytodiagnosis of SRCTs is important because a definite diagnosis is mandatory in preoperative diagnostic workup for presurgical chemotherapy in these cases.
  • With this view in mind, an attempt has been made to diagnose SRCTs in the region of the kidney based on cytomorphology and morphometry alone so as to facilitate its diagnosis in a simple cytology laboratory of a developing country where facilities for auxiliary techniques are not easily available.
  • An aspirate with preponderant malignant round cells that were larger or double the size of red blood cells in air-dried smears or measured less than 10 micro in diameter in alcohol-fixed smears was considered as a small blue-cell tumor.
  • Twenty-one were diagnosed as Wilms' tumor (WT), 10 were diagnosed as neuroblastoma (NB), 3 were ganglioneuroblastoma (GNB), 1 was a cellular congenital mesoblastic nephroma (CMN), and 1 was an adrenocortical carcinoma (ACC).
  • The latter were appreciated only on retrospective analysis after histological confirmation.Thus, morphometry in correlation with cytology, clinical history, physical findings, and radiological data is helpful in guided FNA for a definite diagnosis of SRCT in the region of the kidney.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15754373.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Matsuura Y, Kitajima M, Hachisuga T, Tanimoto A, Okura N, Kihara I: Malignant mixed müllerian tumor with malignant neuroectodermal components (teratoid carcinosarcoma) of the ovary: Report of a case with clinicopathologic findings. J Obstet Gynaecol Res; 2010 Aug;36(4):907-11
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  • [Title] Malignant mixed müllerian tumor with malignant neuroectodermal components (teratoid carcinosarcoma) of the ovary: Report of a case with clinicopathologic findings.
  • Malignant mixed müllerian tumor (MMMT) or carcinosarcoma of the female genital tract is a rare neoplasm.
  • Malignant ovarian tumor composed of müllerian epithelial tumor and malignant germ cell tumor is also rare, with most cases composed of endometrioid adenocarcinoma and yolk sac tumor.
  • Ovarian MMMT with malignant neuroectodermal components resembling immature teratoma is extremely rare.
  • Microscopic examination showed a heterogenous mixed tumor composed of malignant epithelial, malignant mesodermal and malignant neuroectodermal components.
  • The cells of ganglioneuroblastoma-like area were positive for neural markers (Synaptophysin, S-100 protein, neuron-specific enolase).
  • In spite of aggressive combination chemotherapy and three times of laparotomy, the patient died of disease 3 years 10 months after the initial treatment.
  • Further cases need to be accumulated to make diagnosis and to determine a successful treatment modality.

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  • (PMID = 20666968.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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27. Aydn GB, Kutluk MT, Yalçn B, Büyükpamukçu M, Kale G, Varan A, Akyüz C, Senocak ME, Büyükpamukçu N: Neuroblastoma in Turkish children: experience of a single center. J Pediatr Hematol Oncol; 2009 Jul;31(7):471-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Histopathologic subtypes were neuroblastoma (NBL) in 462 patients (92.4%) and ganglioneuroblastoma in 38 patients (7.6%).
  • There were 30, 49, 133, 257, 31 patients with stage 1, 2, 3, 4, 4S disease and their 10-year survival rates were 100%, 75.8%, 34.1%, 6.5%, and 59.4%, respectively.
  • Surgical procedure involving total or near total tumor removal improved the survival (P=0.002).
  • Both 5-year overall survival and event free survival rates were higher when partial resection was performed, especially in stage 3 disease (P=0.002 and P=0.02).
  • In multivariate analysis, age above 18 months at diagnosis (P=0.01), stage 4 disease (P<0.001), abdominal primary tumor site (P<0.001), NBL subtype in histopathology (P=0.001), responsiveness to chemotherapy (P<0.001) positive or high Vanillyl mandelic acid levels (P=0.02) and male sex (P=0.008) were the determinants of poor prognosis.
  • CONCLUSIONS: The survival rates in children with local disease are comparable with the results of developed countries; however, the results in children with advanced disease are still not satisfactory.
  • To improve the outcome, especially in children with advanced disease, more effective chemotherapy regimens and molecular therapies should be investigated.
  • Sharing the knowledge and capacity building to improve the treatment results in NBL are also critical for developing countries.
  • [MeSH-minor] Adolescent. Age Distribution. Age of Onset. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Developing Countries / statistics & numerical data. Female. Humans. Infant. Infant, Newborn. Kaplan-Meier Estimate. Male. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Sex Factors. Survival Rate. Turkey

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  • (PMID = 19564739.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. De Bernardi B, Gambini C, Haupt R, Granata C, Rizzo A, Conte M, Tonini GP, Bianchi M, Giuliano M, Luksch R, Prete A, Viscardi E, Garaventa A, Sementa AR, Bruzzi P, Angelini P: Retrospective study of childhood ganglioneuroma. J Clin Oncol; 2008 Apr 1;26(10):1710-6

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  • Diagnosis was confirmed in 45, while 27 were reclassified as ganglioneuroblastoma intermixed (GNBI) and four were reclassified as other PNT subtypes.
  • Six patients developed tumor progression but survived.
  • Two patients developed a late malignancy but survived.
  • None of the 146 patients received chemotherapy.
  • CONCLUSION: Diagnosis was changed to GNBI for approximately one third of 76 reviewed tumors.

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  • (PMID = 18375900.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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29. Hase T, Ohta S, Tani T, Mizukuro T, Mekata E, Naitoh H, Shimadera S, Fujino S, Taga T: Outcome of infants with neuroblastoma detected by mass screening and surgically treated in Shiga Prefecture, Japan: what is the role of surgery? Pediatr Surg Int; 2002 Sep;18(5-6):289-94
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  • To investigate retrospectively the clinical and biological features that influence the outcome of infants with neuroblastoma (NB) detected by mass screening (NBMS), and to construct surgical strategies to deal with NBMS, 20 infants diagnosed as having either NB or ganglioneuroblastoma (GNB) between 1986 and 1998 were enrolled in a study.
  • The following factors were analyzed by multivariate analysis: age, stage according to the Japanese staging system at the time of diagnosis, site of the primary tumor, histologic findings, preoperative urinary vanillylmandelic acid (VMA) and homovanillic acid (HVA) levels, VMA/HVA ratio, lactate dehydrogenase, neuron-specific enolase, Shimada's histologic classification, amplification of the N- myc oncogene by Southern blot analysis, nuclear content, and chromosomal abnormality.
  • Four infants had stage I, 6 stage II, 3 stage III, 3 stage IVB, and 4 stage IV disease.
  • The infant with N- myc-positive NB (stage II) died 23 months after surgery in spite of aggressive postoperative chemotherapy.
  • The N- myc-positive NB case implies that even in locoregional NB detected by NBMS, surgical excision should play a central role in the diagnosis of its oncogenic characteristics and indicate any subsequent therapy.
  • [MeSH-minor] Biomarkers, Tumor / urine. Female. Homovanillic Acid / urine. Humans. Infant. Japan. Male. Mass Screening. Neoplasm Staging. Prognosis. Retrospective Studies. Treatment Outcome. Vanilmandelic Acid / urine

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  • [CommentIn] Pediatr Surg Int. 2002 Sep;18(5-6):288 [12415340.001]
  • (PMID = 12415341.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 55-10-7 / Vanilmandelic Acid; X77S6GMS36 / Homovanillic Acid
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