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1. Cyriac S, Praveenkumar D, Majhi U, Sagar TG: Follicular dendritic cell sarcoma of the neck with an aggressive and fatal course. J Cancer Res Ther; 2010 Jan-Mar;6(1):114-6
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  • [Title] Follicular dendritic cell sarcoma of the neck with an aggressive and fatal course.
  • Dendritic cell neoplasms are rare malignancies described with an increased frequency.
  • The disease often has an indolent course.
  • Surgery is the main modality though chemotherapy and radiation have also been tried.
  • We present here a case of a 69-year-old male diagnosed to have follicular dendritic cell sarcoma of the neck which had a rapid and fatal course inspite of chemotherapy and radiotherapy.
  • More studies are required to assess the biology of this rare tumor.
  • [MeSH-major] Dendritic Cell Sarcoma, Follicular / pathology. Head and Neck Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Fatal Outcome. Humans. Immunohistochemistry. Male. Radiotherapy

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  • (PMID = 20479564.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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2. Choi BS, Baek JH, Shin YM, Kim JH, Kim HW, Lee SJ, Cha HJ: Follicular dendritic cell sarcoma: a case report and review of the literature. Cancer Res Treat; 2010 Jun;42(2):121-4

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  • [Title] Follicular dendritic cell sarcoma: a case report and review of the literature.
  • Follicular dendritic cells (FDC) are non-lymphoid, non-phagocytic accessory cells of the immune system and these cells are essential for antigen presentation and regulation of the reactions in germinal centers.
  • Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that shows a low-to-intermediate malignant potential.
  • The patient improved after systemic chemotherapy.

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  • (PMID = 20622968.001).
  • [ISSN] 2005-9256
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2901081
  • [Keywords] NOTNLM ; Dendritic cell sarcoma / Dendritic cells / Follicular / Lymph nodes
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3. Toyoda K, Taniguchi J, Kikawa K, Uike N, Haraoka S, Ooshima K, Kikuchi M, Kawanishi H: Follicular dendritic cell sarcoma: ultrastructural and immunohistochemical studies. Intern Med; 2000 Nov;39(11):950-5
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  • [Title] Follicular dendritic cell sarcoma: ultrastructural and immunohistochemical studies.
  • A rare case of follicular dendritic cell (FDC) sarcoma is reported.
  • Computerized tomography showed cervical, supraclavicular, retroperitoneal, and paraaortic lymphadenopathies.
  • Histological findings from a cervical lymph node revealed Hodgkin's disease at first.
  • But tumors that arose both in the cervical and the left interscapular regions during the chemotherapy were immunohistochemically confirmed to be of follicular dendritic cell origin.
  • The ultrastructural findings were consistent with those of FDC sarcoma.
  • FDC sarcoma is a rare nonlymphoid cell-derived malignant tumor originating from the lymphoid tissue.
  • The diagnosis of FDC sarcoma is most accurately established by immunohistochemical methods, using its specific markers.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Dendritic Cells, Follicular / ultrastructure. Sarcoma / pathology. Sarcoma / ultrastructure. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / ultrastructure

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  • (PMID = 11065250.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
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4. Tsunemine H, Akasaka H, Kusama T, Fujimoto K, Motoyama A, Aozasa K, Kodaka T: Hepatic follicular dendritic cell sarcoma favorably controlled by transcatheter arterial chemoembolization. Intern Med; 2010;49(24):2703-7
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  • [Title] Hepatic follicular dendritic cell sarcoma favorably controlled by transcatheter arterial chemoembolization.
  • A 78-year-old woman with multiple tumors in the liver and spleen was diagnosed with follicular dendritic cell (FDC) sarcoma based on the histological picture of splenectomized specimen and its expression of CD21 and CD 23.
  • Since systemic chemotherapies were ineffective for residual liver tumors, transcatheter arterial chemoembolization (TACE) was performed with subsequent tumor reduction.
  • Currently, the patient is alive 27 months after the diagnosis with residual hepatic tumors favorably controlled by repeated TACE.
  • Our experience suggests that TACE is useful for the management of hepatic FDC sarcoma.
  • [MeSH-major] Chemoembolization, Therapeutic. Dendritic Cell Sarcoma, Follicular / therapy. Liver Neoplasms / therapy
  • [MeSH-minor] Aged. Catheterization, Peripheral / methods. Drug Therapy, Combination / methods. Female. Humans

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  • (PMID = 21173546.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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5. Li L, Shi YH, Guo ZJ, Qiu T, Guo L, Yang HY, Zhang X, Zhao XM, Su Q: Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma. World J Gastroenterol; 2010 May 28;16(20):2504-19

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  • [Title] Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma.
  • AIM: To establish a model for prognosis assessment of extranodal follicular dendritic cell (FDC) sarcoma.
  • Six patients had recurrence or metastasis and three remained free of disease.
  • The tumor sizes ranged from 1.5 to 21 cm (mean, 7.4 cm).
  • Surgical resection was performed in 100 patients, followed by radiation and/or chemotherapy in 35 of them.
  • Of the informative cases, 38 (42%) had recurrence or metastasis, and 12 (13%) died of the disease.
  • A size > or = 5 cm (P = 0.003), high-grade histology (P = 0.046) and a mitotic count > or = 5/10 HPF (P = 0.013) were associated with tumor recurrence.
  • CONCLUSION: Extranodal FDC tumors behave like soft tissue sarcomas.
  • [MeSH-major] Dendritic Cell Sarcoma, Follicular / diagnosis. Dendritic Cell Sarcoma, Follicular / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prognosis. Retrospective Studies. Review Literature as Topic. Sarcoma / pathology. Treatment Outcome. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism. Young Adult

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  • (PMID = 20503450.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC2877180
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6. Soriano AO, Thompson MA, Admirand JH, Fayad LE, Rodriguez AM, Romaguera JE, Hagemeister FB, Pro B: Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature. Am J Hematol; 2007 Aug;82(8):725-8
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  • [Title] Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature.
  • Follicular dendritic cell sarcomas (FDCS) are grouped with the histiocytic and dendritic cell neoplasms.
  • The natural history and response to different treatments have not been well established.
  • Information on initial treatment was available in 11 patients, which included surgery alone in one patient, surgery and radiation in two, surgery and chemotherapy in one, chemotherapy alone in three, chemotherapy and radiation in one, surgery followed by radiation and chemotherapy in three patients.
  • In eight patients the initial chemotherapy regimen was cyclophosphamide, doxorubicin, vincristine, and prednisone.
  • Ten patients were alive at a median follow up of 22 months, 3 (23%) of 13 had no evidence of disease, and 7 (53%) of 13 patients were alive with disease.
  • Follicular sarcoma is an aggressive neoplasm.
  • Although most of the patients initially responded to treatment, the majority of them (81%) relapsed.
  • A better understanding of the biology of FDCS could guide our efforts in the development of new treatment modalities for this rare disease.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Treatment Outcome

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  • (PMID = 17373675.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16672
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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7. Suhail Z, Musani MA, Afaq S, Zafar A, Ahmed Ashrafi SK: Follicular dendritic cell sarcoma of tonsil. J Coll Physicians Surg Pak; 2010 Jan;20(1):55-6
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  • [Title] Follicular dendritic cell sarcoma of tonsil.
  • Follicular dendritic cell sarcoma is a very rare entity.
  • We present a new case of follicular dendritic cell sarcoma of the tonsil in a 52 years old woman with no evidence of neck node involvement.
  • The final diagnosis after histological review and immunohistochemical stains was follicular dendritic cell sarcoma.
  • One year follow-up after postoperative chemotherapy showed no evidence of local or regional recurrence.
  • Follicular dendritic cell sarcoma is a rare and underdiagnosed neoplasm.
  • It should be included in the differential diagnosis of any tonsillar mass in adults.
  • Follicular dendritic cell markers such as SR-100, CD21 and/or CD35 are essential for the diagnosis.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Sarcoma / pathology. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 20141695.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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8. Chera BS, Orlando C, Villaret DB, Mendenhall WM: Follicular dendritic cell sarcoma of the head and neck: case report and literature review. Laryngoscope; 2008 Sep;118(9):1607-12
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  • [Title] Follicular dendritic cell sarcoma of the head and neck: case report and literature review.
  • OBJECTIVES/HYPOTHESIS: This article presents a case of a patient with follicular dendritic cell sarcoma (FDS), a rare neoplasm usually of the head and neck, and reviews the literature.
  • He was treated with neck dissection and postoperative irradiation and remains disease free 5.25 years after salvage treatment.
  • Twenty-eight percent of patients received adjuvant radiotherapy; 18% received adjuvant chemotherapy.
  • Fifty percent of patients were alive with no evidence of disease at last follow-up; 9% died from disease.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Head and Neck Neoplasms / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 18596475.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Amiri-Kordestani L, Priebat D, Chia SH: Follicular dendritic cell sarcoma of the neck: case report and review of current diagnostic and management strategies. Ear Nose Throat J; 2010 Jul;89(7):E14-7
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  • [Title] Follicular dendritic cell sarcoma of the neck: case report and review of current diagnostic and management strategies.
  • Follicular dendritic cell sarcoma (FDCS) is a rare malignant neoplasm that can clinically mimic a number of other tumors.
  • The prognosis tends to be worse for patients with large or high-grade tumors and/or an intra-abdominal tumor site.
  • Radiation therapy and/or chemotherapy may be considered for incompletely resected tumors and for tumors with poor prognostic features, but the exact role of adjuvant therapy is unknown.
  • We report a case of cervical FDCS in a 39-year-old black man, and we review the presentation and management of this disorder, with emphasis on the differential diagnosis.
  • [MeSH-major] Dendritic Cell Sarcoma, Follicular / radiography. Dendritic Cell Sarcoma, Follicular / surgery. Head and Neck Neoplasms / radiography. Head and Neck Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Risk Factors

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  • (PMID = 20628972.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Yin WH, Yu GY, Ma Y, Rao HL, Lin SX, Shao CK, Liang Q, Guo N, Chen GQ, Zhou W, Zhao T, Zhu MG: [Follicular dendritic cell sarcoma: a clinicopathologic analysis of ten cases]. Zhonghua Bing Li Xue Za Zhi; 2010 Aug;39(8):522-7
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  • [Title] [Follicular dendritic cell sarcoma: a clinicopathologic analysis of ten cases].
  • OBJECTIVE: To study the clinicopathologic features of follicular dendritic cell sarcoma (FDCS) and its differential diagnosis.
  • Histologically, the tumor cells had whorled, storiform or diffuse growth patterns.
  • Multinucleated tumor giant cells and intranuclear pseudoinclusions were occasionally seen.
  • There was a sprinkling of small lymphocytes and neutrophils within the tumor as well as in the perivascular region.
  • Immunohistochemical study showed that the tumor cells were diffusely or focally positive for CD21, CD23, CD35 and D2-40, but negative for LCA, CD20, CD3, CD1a, HMB45 and CK.
  • The remaining 5 patients were alive and disease-free after surgical excision (+/- chemotherapy and radiotherapy).
  • CONCLUSIONS: FDCS is a rare low to intermediate-grade malignant tumor.
  • Appropriate application of FDC markers, such as CD21, CD35 and D2-40, would be helpful for arriving at a correct diagnosis.
  • Most cases are associated with good prognosis after surgical treatment, with or without chemotherapy and radiotherapy.
  • [MeSH-major] Dendritic Cell Sarcoma, Follicular / pathology. Lymph Nodes / pathology. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Murine-Derived / metabolism. Dendritic Cell Sarcoma, Interdigitating / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lymph Node Excision. Male. Meningioma / pathology. Middle Aged. Nasopharyngeal Neoplasms / pathology. Paraneoplastic Syndromes / complications. Pemphigus / complications. Receptors, Complement 3b / metabolism. Receptors, Complement 3d / metabolism. Receptors, IgE / metabolism. Young Adult

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  • (PMID = 21055030.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Receptors, Complement 3b; 0 / Receptors, Complement 3d; 0 / Receptors, IgE; 0 / monoclonal antibody D2-40
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11. Ludwig A: [Extranodal follicular dendritic cell sarcoma of the tonsils]. HNO; 2006 Sep;54(9):701-4
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  • [Title] [Extranodal follicular dendritic cell sarcoma of the tonsils].
  • [Transliterated title] Extranodales follikuläres dendritisches Sarkom der Tonsille.
  • Follicular dendritic cell (FDC) sarcoma is a rare tumor deriving from dendritic cells of the lymphoid follicle.
  • Only a few cases of extranodal manifestation of FDC sarcoma of the head and neck have been reported.
  • We describe the case of a 47-year-old woman with a FDC sarcoma of the left tonsil that first manifested 11 years ago.
  • She has suffered three recurrences since this time, at continually reducing intervals.
  • The patient underwent local tumor excisions, and then received an adjuvant chemotherapy with doxorubicin and ifosfamide when she presented with the third recurrence.
  • The 11 year follow-up bears out a more aggressive behaviour of FDC sarcoma than first assumed.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Sarcoma / pathology. Tonsillar Neoplasms / pathology

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  • [Cites] ORL J Otorhinolaryngol Relat Spec. 2002 May-Jun;64(3):229-32 [12037393.001]
  • [Cites] Am J Hematol. 1998 Oct;59(2):161-7 [9766802.001]
  • [Cites] Ear Nose Throat J. 2003 Jul;82(7):507-9 [12955835.001]
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  • (PMID = 16389561.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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12. Aboujaoude R, Alvarez JR, Alvarez M, Al-Khan A: Follicular dendritic cell sarcoma in pregnancy: case report and review of the literature. Am J Perinatol; 2006 Nov;23(8):459-61
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  • [Title] Follicular dendritic cell sarcoma in pregnancy: case report and review of the literature.
  • Follicular dendritic cell (FDC) sarcoma is a rare tumor.
  • We describe the case of a 20-year-old woman with a FDC sarcoma diagnosed during pregnancy that initially presented as a painful mass in the right axilla.
  • The patient underwent a tumor excision and chemotherapy.
  • During her postpartum course, she received radiation therapy and chemotherapy.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Pregnancy Complications, Neoplastic / diagnosis. Sarcoma / diagnosis

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  • (PMID = 17094047.001).
  • [ISSN] 0735-1631
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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13. Chan AC, Chan KW, Chan JK, Au WY, Ho WK, Ng WM: Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies. Histopathology; 2001 Jun;38(6):510-8
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  • [Title] Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies.
  • AIMS: Hyaline-vascular Castleman's disease (HVCD) and follicular dendritic cell (FDC) sarcoma occurring in the nasopharynx are both extremely rare.
  • Hyaline- vascular Castleman's disease with FDC overgrowth was diagnosed in a recurrence 8 years later, and a frank FDC sarcoma developed at the same site 11 years after initial presentation.
  • The patient remained disease-free 3 years after excision and adjuvant chemotherapy.
  • The FDC sarcoma comprised swirling fascicles of spindly cells with indistinct cell borders.
  • The tumour cells expressed the FDC markers CD21, CD35 and CNA.42 and in-situ hybridization for Epstein-Barr virus-encoded RNAs was negative.
  • Over-expression of p53 protein was observed in the FDC sarcoma and an increased number of weakly p53-positive spindly cells could also be demonstrated in the HVCD specimen.
  • This finding suggested a possible role of p53 in the evolution from HVCD to FDC sarcoma.
  • Critical analysis of the literature shows that, among the 13 reported cases of FDC sarcoma associated with Castleman's disease, possible progression from the latter to the former is documented in only two cases.
  • CONCLUSIONS: The sequential changes observed in the current case provide further evidence to strengthen the role of HVCD as a possible precursor of FDC sarcoma.
  • [MeSH-major] Dendritic Cells / pathology. Giant Lymph Node Hyperplasia / pathology. Nasopharyngeal Neoplasms / pathology. Nasopharynx / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Antigens, Neoplasm / analysis. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Biomarkers, Tumor / analysis. Biopsy. Cell Transformation, Neoplastic. Chemotherapy, Adjuvant. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Humans. Immunoenzyme Techniques. Male. Prednisone / administration & dosage. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 11422494.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
  • [Number-of-references] 28
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14. Pisani F, Marino M, Sentinelli S, Petti MC: Follicular dendritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin. J Exp Clin Cancer Res; 2008;27:33
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  • [Title] Follicular dendritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin.
  • BACKGROUND: Follicular dendritic cell (FDC) sarcoma is a rare neoplasm arising in lymph nodes but also in extranodal sites from accessory cells of the immune system that are essential for the function of antigen presentation and germinal center reaction regulation.
  • FDC sarcoma has a significant recurrent and metastatic potential and for these reason it should be viewed as an intermediate grade malignancy.
  • Immunohistochemically, tumor cells were diffusely positive for follicular dendritic cell markers CD21, CD23 and negative for cytokeratin.The patient after complete excision of the lymph node underwent five courses of adjuvant chemotherapy with COP plus PEG-liposomal doxorubicin, considering the propensity of the tumor to metastasize.
  • CONCLUSION: These results suggest that this therapeutic modality may be useful in the management of FDC sarcoma.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Dendritic Cell Sarcoma, Follicular / therapy. Doxorubicin / therapeutic use. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Female. Humans. Lymph Nodes / pathology. Middle Aged. Receptors, Complement 3d / immunology. Receptors, IgE / immunology

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  • [Cites] Am J Pathol. 1986 Mar;122(3):562-72 [2420185.001]
  • [Cites] Tumori. 2003 May-Jun;89(3):237-49 [12908776.001]
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  • [Cites] Histopathology. 2001 Jun;38(6):510-8 [11422494.001]
  • [Cites] Mod Pathol. 2002 Jan;15(1):50-8 [11796841.001]
  • [Cites] Histopathology. 2002 Jul;41(1):1-29 [12121233.001]
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  • [Cites] Auris Nasus Larynx. 2002 Oct;29(4):401-3 [12393051.001]
  • [Cites] Oral Oncol. 2003 Jun;39(4):415-9 [12676264.001]
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  • [Cites] Cancer. 1997 Jan 15;79(2):294-313 [9010103.001]
  • (PMID = 18761751.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Receptors, Complement 3d; 0 / Receptors, IgE; 80168379AG / Doxorubicin
  • [Other-IDs] NLM/ PMC2556649
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15. Nakashima T, Kuratomi Y, Shiratsuchi H, Yamamoto H, Yasumatsu R, Yamamoto T, Komiyama S: Follicular dendritic cell sarcoma of the neck; a case report and literature review. Auris Nasus Larynx; 2002 Oct;29(4):401-3
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  • [Title] Follicular dendritic cell sarcoma of the neck; a case report and literature review.
  • Follicular dendritic cell (FDC) sarcomas, also known as dendritic reticulum cell tumors, are uncommon neoplasms arising from antigen-presenting cells in B-lymphofollicles of nodal and extra-nodal sites.
  • We report a case of FDC sarcoma arising in the neck.
  • A 56-year-old female presented with a left neck tumor.
  • Microscopically, the tumor showed spindle-shaped stromal cells with large oval and polygonal nuclei.
  • Adjuvant chemotherapy of cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP) was given.
  • Literature review provides the current information for the diagnosis and treatment of this unusual tumor.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / radiography. Sarcoma / pathology. Sarcoma / radiography
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Middle Aged

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  • (PMID = 12393051.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 9
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16. Yang GC, Wang J, Yee HT: Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. Acta Cytol; 2006 Sep-Oct;50(5):534-8
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  • [Title] Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report.
  • BACKGROUND: Follicular dendritic cell (FDC) tumor is a rare tumor derived from accessory cells in the lymphoid follicles.
  • FDC tumors are typically diagnosed on histology based on immunoreactivity to at least 1 of the FDC markers (CD21, CD23 or CD35) or based on the characteristic ultrastructural feature of long, interwoven, cytoplasmic, dendritic processes connected by desmosomes.
  • CASE: We observed novel cytologic features of FDC sarcoma in a liver fine needle aspirate of a 46-year-old man status post surgery and chemotherapy for FDC sarcoma, originating in the gastrointestinal tract with metastases to the liver, pancreas and spleen.
  • In the Diff-Quik- and Papanicolaou-stained smears, the tumor cells presented in syncytial fragments as well as single cells, as previously reported in the cytologic literature.
  • The tumor cells possessed multipolar cytoplasmic processes rather than unipolar ones, as previously reported.
  • CONCLUSION: The ultrastructural features of a web of interwoven, dendritic, cytoplasmic processes of FDC tumor was demonstrated for the first time on cytology.
  • Observation of this feature may allow the diagnosis to be made on cytology prior to histology, immunohistochemistry or electron microscopy.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Gastrointestinal Neoplasms / pathology. Liver Neoplasms / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Antigens, Surface / analysis. Antigens, Surface / immunology. Antigens, Surface / metabolism. Biomarkers, Tumor / analysis. Biomarkers, Tumor / immunology. Biomarkers, Tumor / metabolism. Biopsy, Needle. Cell Shape. Diagnosis, Differential. Humans. Liver / pathology. Lymph Nodes / pathology. Male. Middle Aged. Papanicolaou Test / methods. Papanicolaou Test / standards. Predictive Value of Tests

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  • (PMID = 17017440.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / Biomarkers, Tumor
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17. Jiang L, Admirand JH, Moran C, Ford RJ, Bueso-Ramos CE: Mediastinal follicular dendritic cell sarcoma involving bone marrow: a case report and review of the literature. Ann Diagn Pathol; 2006 Dec;10(6):357-62
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  • [Title] Mediastinal follicular dendritic cell sarcoma involving bone marrow: a case report and review of the literature.
  • We report a rare case of mediastinal follicular dendritic cell (FDC) sarcoma involving the bone marrow.
  • The patient, a 46-year-old woman, had a clinically aggressive tumor in the anterior mediastinum that was initially diagnosed as a diffuse B-cell lymphoma.
  • She received chemotherapy but showed no significant improvement.
  • The diagnosis of FDC sarcoma was made based on histological examination and immunohistochemical findings, including strong positive staining of tumor cells for CD21, CD23, clusterin, and epidermal growth factor receptor (EGFR) and negative staining for CD20, CD30, CD45, CD1a, S-100, vimentin, and keratin cocktail.
  • Histological examination and immunohistochemical studies of a previous biopsy of the mediastinal mass confirmed the diagnosis of mediastinal FDC sarcoma.
  • The patient was treated with an appropriate chemotherapy regimen; 1 month later, follow-up bone marrow biopsy revealed no tumor cells.
  • Although FDC sarcoma is considered a low-grade tumor, the tumor in the present case not only developed at an unusual location with bone metastasis but also involved bone marrow.
  • This case also highlights the utility of EGFR as an immunohistochemical marker of dendritic cell tumors that could be used as a diagnostic tool and guide for choosing appropriate chemotherapy regimens.
  • [MeSH-major] Bone Marrow / pathology. Dendritic Cells, Follicular / pathology. Mediastinal Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Etoposide / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Immunoenzyme Techniques. Methotrexate / administration & dosage. Middle Aged. Taxoids / administration & dosage. Treatment Outcome

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  • (PMID = 17126255.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Taxoids; 0W860991D6 / Deoxycytidine; 15H5577CQD / docetaxel; 6PLQ3CP4P3 / Etoposide; B76N6SBZ8R / gemcitabine; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate
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18. Khalid T, Folman R: Symptoms in cancer patients and an unusual tumor: Case 3. Follicular dendritic cell sarcoma. J Clin Oncol; 2005 Dec 20;23(36):9425-6
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  • [Title] Symptoms in cancer patients and an unusual tumor: Case 3. Follicular dendritic cell sarcoma.
  • [MeSH-major] Liver Neoplasms / drug therapy. Sarcoma / drug therapy
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / administration & dosage. Dendritic Cells. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Doxorubicin / administration & dosage. Humans. Male. Prednisone / administration & dosage. Tomography, X-Ray Computed. Vinblastine / administration & dosage. Vinblastine / analogs & derivatives. Vincristine / administration & dosage

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  • (PMID = 16361643.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 5J49Q6B70F / Vincristine; 5V9KLZ54CY / Vinblastine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; B76N6SBZ8R / gemcitabine; Q6C979R91Y / vinorelbine; VB0R961HZT / Prednisone; CHOP protocol
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19. Azim HA, Elsedewy E, Azim HA Jr: Imatinib in the treatment of follicular dendritic sarcoma: a case report and review of literature. Onkologie; 2007 Jul;30(7):381-4
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  • [Title] Imatinib in the treatment of follicular dendritic sarcoma: a case report and review of literature.
  • Follicular dendritic cell sarcoma is a rare, malignant, non-lymphoid cell-derived tumor that originates from B-lymphoid follicles of nodal and extranodal sites.
  • Surgery and radiotherapy were considered the mainstay of treatment for localized disease.
  • As for the metastatic setting, classic lymphoma and sarcoma regimens were previously tested with dismal responses.
  • PATIENT AND METHODS: In this report, we examined imatinib in combination with gemcitabine and cisplatin for treating a male patient with metastatic follicular dendritic sarcoma to the liver and lung.
  • RESULTS: The patient achieved complete pathological remission confirmed by positron emission tomography (PET) scan after 8 cycles.
  • CONCLUSION: Our case is the first to report a role for imatinib and to show complete pathological remission in this rare disease.
  • An imatinibbased combination could serve as a good therapeutic option for such cases.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dendritic Cells, Follicular. Head and Neck Neoplasms / drug therapy. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Sarcoma / secondary
  • [MeSH-minor] Benzamides. Biomarkers, Tumor / analysis. Cisplatin / administration & dosage. Cisplatin / adverse effects. Deoxycytidine / administration & dosage. Deoxycytidine / adverse effects. Deoxycytidine / analogs & derivatives. Follow-Up Studies. Humans. Imatinib Mesylate. Lymphatic Metastasis / pathology. Male. Middle Aged. Positron-Emission Tomography. Proto-Oncogene Proteins c-kit / analysis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17596748.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Benzamides; 0 / Biomarkers, Tumor; 0 / Piperazines; 0 / Pyrimidines; 0W860991D6 / Deoxycytidine; 8A1O1M485B / Imatinib Mesylate; B76N6SBZ8R / gemcitabine; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 20
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20. Li J, Duan MH, Han B, Zhang W, Zhou DB, Zhao YQ, Shen T: [Dendritic cell sarcoma: 4 cases report with literature review]. Zhonghua Xue Ye Xue Za Zhi; 2008 Apr;29(4):263-6
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  • [Title] [Dendritic cell sarcoma: 4 cases report with literature review].
  • OBJECTIVE: To describe the clinical and pathological features, treatment and prognosis of dendritic cell sarcoma (DCS).
  • METHODS: A group of DCS was described, including two cases of follicular dendritic cell sarcoma (FDCS), one each of interdigitating dendritic cell sarcoma (IDCS) and langerhans cell sarcoma (LCS).
  • Pathological diagnosis of lymph node biopsy was FDCS with positive CD21 and CD35.
  • Both patients achieved complete remission (CR) after 6 cycles of chemotherapy (CHOP: cyclophosphamide, epirubicin, vindesine, and prednisolone).
  • The diagnosis of LCS was established after excisional biopsy was taken from inguinal lymph node.
  • Electron microscope examination confirmed the presence of Birbeck granule in tumor cells.
  • Four cycles of chemotherapy (including ECHOP, FND) were administered, but the disease progressed.
  • CONCLUSION: DCS is a group of very rare sarcoma, FDCS, IDCS and LCS have different characteristic clinical features, immunophenotype and prognosis.
  • [MeSH-major] Dendritic Cell Sarcoma, Interdigitating

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  • (PMID = 18843982.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 13
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21. Bradshaw EJ, Wood KM, Hodgkinson P, Lucraft H, Windebank KP: Follicular dendritic cell tumour in a 9-year-old child. Pediatr Blood Cancer; 2005 Oct 15;45(5):725-7
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  • [Title] Follicular dendritic cell tumour in a 9-year-old child.
  • Follicular dendritic cell tumour (FDCT) or sarcoma is a rare tumour first described in 1986.
  • Our patient first presented at 9 years of age with a cervical mass that was removed and revealed an apparently benign, but florid reactive process.
  • Radical block dissection showed disease to level III and 6 weeks of radiotherapy was followed by 6 months adjuvant chemotherapy.
  • Three years after completing his final treatment he shows no signs of recurrent disease.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Head and Neck Neoplasms / pathology. Lymph Nodes / pathology

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  • (PMID = 15926163.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Vargas H, Mouzakes J, Purdy SS, Cohn AS, Parnes SM: Follicular dendritic cell tumor: an aggressive head and neck tumor. Am J Otolaryngol; 2002 Mar-Apr;23(2):93-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Follicular dendritic cell tumor: an aggressive head and neck tumor.
  • OBJECTIVE: To characterize the clinicopathologic features of head and neck follicular dendritic cell (FDC) tumor and report the experience of this entity at our institution.
  • STUDY DESIGN: Two case presentations are compared with a retrospective analysis of all published head and neck cases.
  • RESULTS: Thirty four cases of FDC tumor of the head and neck cases have been published.
  • Patients were treated with surgery (17), surgery and chemotherapy (8), and surgery and radiation (9).
  • After the primary treatment, 12 patients had no evidence of disease, whereas 5 were incurable.
  • Of these 13 patients who suffered recurrences, 4 had no evidence of disease after secondary treatment, 6 were alive with disease, and one was lost to follow up.
  • CONCLUSION: FDC tumor is a rare malignant neoplasm that can present in the head and neck region in both lymph nodes and extranodal sites.
  • Surgery has been the mainstay of treatment and should include diligent control of surgical margins.
  • The role of adjuvant therapy remains controversial.
  • We believe that FDC tumor should be viewed and treated as a moderately aggressive head and neck tumor.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Head and Neck Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Middle Aged. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery. Severity of Illness Index. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright 2002, Elsevier Science (USA). All rights reserved.)
  • (PMID = 11893977.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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23. Wu Q, Liu C, Lei L, Yan X, Wang B, Liu X, Yv L, Lv Y: Interdigitating dendritic cell sarcoma involving bone marrow in a liver transplant recipient. Transplant Proc; 2010 Jun;42(5):1963-6
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  • [Title] Interdigitating dendritic cell sarcoma involving bone marrow in a liver transplant recipient.
  • Liver transplantation is an effective treatment for patients with many kinds of liver diseases.
  • However, an increased risk of de novo malignancy has been reported in liver transplant recipients; immunosuppressive drugs have generally been identified as the primary culprit.
  • Interdigitating dendritic cell sarcoma (IDCS) is an exceedingly rare neoplasm arising from antigen-presenting cells of the immune system.
  • In this study, we have reported a case of IDCS with bone marrow involvement occurring in a 61-year-old female liver transplant recipient at 2 years after the procedure.
  • Routine examination revealed an abnormal white blood cell count and elevated serum lactate dehydrogenase.
  • Computerized tomography of the chest, abdomen, and pelvis were negative.
  • To obtain a definite diagnosis, we performed an excisional lymph node biopsy and a bone marrow biopsy.
  • Microscopically, the tumor was composed of spindle cells with pale to eosinophilic cytoplasm, ill-defined cell borders, and large pleomorphic nuclei with prominent nucleoli.
  • Follicular dendritic cell, lymphoid, epithelial, myoepithelial, and melanoma markers were negative.
  • She responded to chemotherapy.
  • This case demonstrates the importance of cancer prevention and early detection for liver transplant recipients.
  • [MeSH-major] Bone Marrow / pathology. Carcinoma, Hepatocellular / surgery. Dendritic Cell Sarcoma, Interdigitating / complications. Liver Neoplasms / surgery. Liver Transplantation / methods
  • [MeSH-minor] Female. Hepatitis B / complications. Humans. Liver Cirrhosis / surgery. Liver Cirrhosis / virology. Lymph Nodes / pathology. Middle Aged. Treatment Outcome

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  • (PMID = 20620556.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Mozek C, Novotny J, Dührsen U, Metz KA: [Lymphadenopathy in the groin. Unusual etiology in a 65-year-old patient]. Internist (Berl); 2004 Jan;45(1):90-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologically a follicular dendritic reticular cell tumor was found.
  • Because there are aggressive forms of this tumor and no established standard therapy, we decided to treat her with surgery followed by a combined radio- and chemotherapy.
  • Despite this treatment 16 months after the first diagnosis a relapse occurred with a metastasis of the follicular dendritic cell tumor in the lung.
  • The optimal management of this kind of tumor is not known.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Groin. Lymph Nodes / pathology. Lymphoma, Large B-Cell, Diffuse / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Prognosis

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  • [Cites] Histopathology. 2002 Jul;41(1):1-29 [12121233.001]
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  • (PMID = 14735246.001).
  • [ISSN] 0020-9554
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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25. Shimazaki K, Ohshima K, Haraoka S, Suzumiya J, Nakamura N, Kikuchi M: Accessory cell tumour: a clinicopathological study of 16 aggressive tumours containing EBV-positive Hodgkin and Reed-Sternberg-like giant cells. Histopathology; 2002 Jan;40(1):12-21
MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accessory cell tumour: a clinicopathological study of 16 aggressive tumours containing EBV-positive Hodgkin and Reed-Sternberg-like giant cells.
  • AIMS: Lymph nodes contain non-lymphoid accessory cells including follicular dendritic cells and interdigitating dendritic cells.
  • We present here the clinicopathological features of 16 cases of accessory cell tumour.
  • Tumour cells were composed of oval-to-spindle cells arranged in diffuse, vague storiform, fascicular and sometimes whorled patterns in a background of small lymphocytes.
  • Electron microscopic examination showed that many of the tumour cells had numerous interwoven long villous cell processes connected by occasional desmosomes.
  • Many tumours were very refractory to chemotherapy and radiation, with a few exceptions, and half of the cases classified initially as stage IV.
  • A short survival time, of 10 months or less, was observed in seven of 16 patients.
  • CONCLUSIONS: Our study identified more aggressive behaviour of accessory cell tumours.
  • [MeSH-major] Dendritic Cells, Follicular / pathology. Herpesvirus 4, Human / isolation & purification. Lymph Nodes / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Reed-Sternberg Cells / pathology. Sarcoma / pathology
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Blotting, Southern. DNA, Neoplasm / analysis. Desmosomes / ultrastructure. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization. Male. Middle Aged. RNA, Viral / analysis

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  • (PMID = 11903594.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / RNA, Viral
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26. Medina M, De Palma G, Ribes-Koninckx C, Calabuig M, Sanz Y: Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients. J Inflamm (Lond); 2008;5:19
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Coeliac disease (CD) is an enteropathy characterized by an aberrant immune response to cereal-gluten proteins.
  • METHODS: The effect of faeces of 26 CD patients with active disease (mean age 5.5 years, range 2.1-12.0 years), 18 symptom-free coeliac disease (SFCD) patients (mean age 5.5 years, range 1.0-12.3 years) on a gluten-free diet for 1-2 years; and 20 healthy children (mean age 5.3 years, range 1.8-10.8 years) on induction of cytokine production and surface antigen expression in peripheral blood mononuclear cells (PBMCs) were determined.
  • RESULTS: Faeces of both active CD and SFCD patients, representing an imbalanced microbiota, significantly increased TNF-alpha production and CD86 expression in PBMCs, while decreased IL-10 cytokine production and CD4 expression compared with control samples.
  • CONCLUSION: The intestinal microbiota of CD patients could contribute to the Th1 pro-inflammatory milieu characteristic of the disease, while B. longum ES1 and B. bifidum ES2 could reverse these deleterious effects.
  • These findings hold future perspectives of interest in CD therapy.

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  • (PMID = 18980693.001).
  • [ISSN] 1476-9255
  • [Journal-full-title] Journal of inflammation (London, England)
  • [ISO-abbreviation] J Inflamm (Lond)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2640389
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