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1. Horta R, Barreto F, Marques M, Rebelo M, Reis JC, Lopes JM, Amarante JM: Epithelial-myoepithelial parotid carcinoma after kidney transplantation. Ecancermedicalscience; 2008;2:92
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  • The occurrence of a second malignant neoplasm (SMN) in patients who have been submitted to kidney transplantation is increasing and causes concern; parotid carcinoma is rarely reported after transplantation and may be related to long-term chemotherapy.Salivary gland carcinomas displaying exclusively myoepithelial differentiation-myoepithelial carcinomas (EMC) are rare, being less than 1% of all salivary gland tumours.
  • EMC arises most commonly in the parotid gland and usually occurs in women.

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  • (PMID = 22275975.001).
  • [ISSN] 1754-6605
  • [Journal-full-title] Ecancermedicalscience
  • [ISO-abbreviation] Ecancermedicalscience
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3234068
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2. Wen XY, Mandelbaum S, Li ZH, Hitt M, Graham FL, Hawley TS, Hawley RG, Stewart AK: Tricistronic viral vectors co-expressing interleukin-12 (1L-12) and CD80 (B7-1) for the immunotherapy of cancer: preclinical studies in myeloma. Cancer Gene Ther; 2001 May;8(5):361-70
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  • A murine stem cell virus (MSCV)-based retroviral vector (MSCV-hIL12.B7) utilized distinct IRES sequences from the encephalomyocarditis virus (EMCV) and the foot-and-mouth disease virus (FMCV), whereas Ad5-based adenovirus vectors contained transcriptional units with two EMCV IRES sequences under the control of murine (AdMh12.B7) or human (AdHh12.B7) cytomegalovirus promoters.
  • These results suggest potential clinical utility of AdMh12.B7 in immunotherapy strategies for the treatment of multiple myeloma and other cancers.
  • [MeSH-major] Adenoviridae / genetics. Antigens, CD80 / genetics. Genetic Vectors. Immunotherapy / methods. Interleukin-12 / genetics. Neoplasms / therapy. Retroviridae / genetics. Tumor Cells, Cultured / drug effects
  • [MeSH-minor] Cytotoxicity Tests, Immunologic. Cytotoxicity, Immunologic. DNA, Complementary. Drug Therapy, Combination. Flow Cytometry. Gene Transfer Techniques. Humans. T-Lymphocytes / immunology

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  • (PMID = 11477456.001).
  • [ISSN] 0929-1903
  • [Journal-full-title] Cancer gene therapy
  • [ISO-abbreviation] Cancer Gene Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD80; 0 / DNA, Complementary; 187348-17-0 / Interleukin-12
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3. Ham KD, Carlson CS: Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys. J Bone Miner Res; 2004 May;19(5):823-9
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  • [Title] Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys.
  • INTRODUCTION: Estrogen replacement therapy (ERT) decreases the risk of osteoporosis and osteoarthritis (OA) in postmenopausal women and has been shown to have direct effects on cells of the bone and cartilage.
  • At necropsy, the proximal tibias of 20 randomly selected animals from each treatment group were embedded in bioplastic and sectioned.
  • Areas and labels were measured in a carefully defined region of the SC bone and epiphyseal/metaphyseal cancellous (EMC) bone, and derived dynamic and static indices were compared between the SC and EMC bone and among the three treatment groups.
  • Student's t-tests and ANOVA were used to compare the data.
  • RESULTS AND CONCLUSIONS: In both the SC and EMC bone, most of the values for the dynamic indices were highest in the OVX control group, intermediate in the SPE group, and lowest in the ERT group.
  • The mineralizing surface, double-labeled surface, and bone formation rate (surface referent) were significantly higher in the SC bone compared with the EMC bone in the OVX control group.
  • In conclusion, the bone turnover indices were higher in the SC bone compared with the EMC bone, and ERT decreased these indices in both sites.
  • [MeSH-major] Bone Remodeling / drug effects. Epiphyses / metabolism. Estrogen Replacement Therapy. Tibia / anatomy & histology. Tibia / metabolism
  • [MeSH-minor] Age Factors. Animals. Body Weight. Calcification, Physiologic / drug effects. Calcification, Physiologic / physiology. Female. Macaca fascicularis. Ovariectomy. Random Allocation

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  • (PMID = 15068506.001).
  • [ISSN] 0884-0431
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / RR14099
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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4. McGrory JE, Rock MG, Nascimento AG, Oliveira AM: Extraskeletal myxoid chondrosarcoma. Clin Orthop Relat Res; 2001 Jan;(382):185-90
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  • [Title] Extraskeletal myxoid chondrosarcoma.
  • The medical records and histologic material of 16 patients with extraskeletal myxoid chondrosarcoma were reviewed.
  • Treatment of the primary site included wide excision or amputation in 13 patients and marginal or intralesional resections with radiation in three patients.
  • Local recurrence developed in four, and metastases developed in six of 13 patients presenting with localized disease.
  • Of six patients who received chemotherapy for systemic disease, four had disease progression and died, and two had a response to chemotherapy (one partial, one complete).
  • The current series suggests that extraskeletal myxoid chondrosarcoma is an intermediate-grade neoplasm with a tendency toward recurrence and metastasis.
  • More effective therapy for systemic disease is needed.
  • [MeSH-major] Chondrosarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Amputation. Chemotherapy, Adjuvant. Disease Progression. Disease-Free Survival. Female. Follow-Up Studies. Humans. Leg / surgery. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Radiotherapy, Adjuvant. Remission Induction. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 11153986.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Schellekens H, Geelen G, Meritet JF, Maury C, Tovey MG: Oromucosal interferon therapy: relationship between antiviral activity and viral load. J Interferon Cytokine Res; 2001 Aug;21(8):575-81
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  • [Title] Oromucosal interferon therapy: relationship between antiviral activity and viral load.
  • Intraperitoneal (i.p.) administration of 20,000 IU recombinant murine IFN-alpha (rMuIFN-alpha) was highly effective in protecting mice challenged i.p. with doses of encephalomyocarditis virus (EMCV) ranging from 44 to 440 LD(50) (p<0.001).
  • ) IFN therapy was also found to be effective in protecting mice challenged with a lethal dose of EMCV.
  • Thus, 40% of animals infected with 44 LD(50) of EMCV and treated o.m. with 20,000 IU rMuIFN-alpha survived infection with a mean survival time of 12.0 +/- 2.46 days relative to a mean of 6.11 +/- 0.38 days in the control group (p<0.05).
  • Oromucosal IFN therapy was found to be ineffective, however, in animals infected with higher doses of EMCV (88-440 LD(50)), even though intraperitoneal administration of the same dose of rMuIFN-alpha resulted in the survival of 90%, 50%, and 60% of animals infected with 88, 220, and 440 LD(50) of EMCV, respectively.
  • These results suggest that oromucosal IFN therapy is effective at relatively low viral load only and that the mechanism of action of oromucosal IFN therapy may be different from that of parenterally administered IFN.
  • Our results suggest that oromucosal IFN therapy may be most effective in chronic viral infections as an alternative to parenterally administered IFN, which is clinically effective but poorly tolerated.
  • [MeSH-major] Antiviral Agents / administration & dosage. Cardiovirus Infections / drug therapy. Cardiovirus Infections / virology. Interferon Type I / administration & dosage. Viral Load
  • [MeSH-minor] Administration, Intranasal. Animals. Encephalomyocarditis virus / drug effects. Injections, Intraperitoneal. Lethal Dose 50. Male. Mice. Mouth Mucosa / drug effects. Mouth Mucosa / virology. Oropharynx. Recombinant Proteins. Survival Rate

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  • (PMID = 11559435.001).
  • [ISSN] 1079-9907
  • [Journal-full-title] Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • [ISO-abbreviation] J. Interferon Cytokine Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Interferon Type I; 0 / Recombinant Proteins
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6. Ben-Dor I, Itsykson P, Goldenberg D, Galun E, Reubinoff BE: Lentiviral vectors harboring a dual-gene system allow high and homogeneous transgene expression in selected polyclonal human embryonic stem cells. Mol Ther; 2006 Aug;14(2):255-67
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  • Genetic modification of human embryonic stem cells (hESCs) is highly valuable for their exploitation in basic science and therapeutic applications.
  • Here we developed lentiviral vectors (LVs) constitutively expressing a reporter and a selectable marker to enable high and homogeneous transgene expression within polyclonal hESCs.
  • LVs carrying GFP and a downstream puromycin resistance gene, linked by the encephalomyocarditis virus (EMCV) or poliovirus internal ribosome entry sites (IRES), allowed homogeneous GFP expression after antibiotic selection.
  • We also developed dual-promoter vectors harboring a reporter and an antibiotic resistance gene under the regulation of human EF1alpha and PGK1 promoters, respectively.
  • In summary, we developed bicistronic and novel dual-promoter LVs that enable high and homogeneous expression of transgenes by polyclonal hESCs after antibiotic selection.
  • [MeSH-minor] Animals. Cell Line. Cell Line, Tumor. CpG Islands / genetics. Cricetinae. Drug Resistance / genetics. Embryo, Mammalian / cytology. Encephalomyocarditis virus. Green Fluorescent Proteins. Humans. Phenotype. Promoter Regions, Genetic. Puromycin / pharmacology

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  • (PMID = 16632408.001).
  • [ISSN] 1525-0016
  • [Journal-full-title] Molecular therapy : the journal of the American Society of Gene Therapy
  • [ISO-abbreviation] Mol. Ther.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS046559-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins; 4A6ZS6Q2CL / Puromycin
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7. Kishimoto C, Takada H, Kawamata H, Umatake M, Ochiai H: Immunoglobulin treatment prevents congestive heart failure in murine encephalomyocarditis viral myocarditis associated with reduction of inflammatory cytokines. J Pharmacol Exp Ther; 2001 Nov;299(2):645-51
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  • [Title] Immunoglobulin treatment prevents congestive heart failure in murine encephalomyocarditis viral myocarditis associated with reduction of inflammatory cytokines.
  • We have previously shown that immunoglobulin therapy suppressed murine coxsackievirus B3 myocarditis.
  • In the present study, we examined the effects of immunoglobulin upon murine myocarditis induced by encephalomyocarditis virus, which is not pathogenic to humans.
  • Antiviral activity of immunoglobulin (Venilon) against encephalomyocarditis virus could not be detected in vitro.
  • The production of cytokines was decreased in virus-infected macrophages by the treatment of immunoglobulin in vitro.
  • Immunoglobulin administration suppressed the development of myocardial necrosis with T-lymphocyte infiltrates in mice not only in the acute viremic but in the chronic aviremic stages concomitantly associated with the reduction of inflammatory cytokines, i.e., tumor necrosis factor-alpha, interferon-gamma, macrophage inflammatory protein-2, and interleukin-6.
  • Taken together, immunoglobulin therapy could have the potential to prevent congestive heart failure.
  • [MeSH-major] Cardiovirus Infections / therapy. Cytokines / biosynthesis. Encephalomyocarditis virus. Heart Failure / prevention & control. Immunization, Passive
  • [MeSH-minor] Animals. Cell Line. Mice. Myocardium / pathology. Organ Size / drug effects

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  • (PMID = 11602677.001).
  • [ISSN] 0022-3565
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines
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8. Gupta P, Bajpai SK, Chandra K, Singh KL, Tandon JS: Antiviral profile of Nyctanthes arbortristis L. against encephalitis causing viruses. Indian J Exp Biol; 2005 Dec;43(12):1156-60
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  • The ethanolic extracts, various fractions and two pure compounds isolated from the plant N. arbortris were tested against Encephalomyocarditis Virus (EMCV) and Semliki Forest Virus (SFV).
  • [MeSH-major] Encephalomyocarditis virus / drug effects. Oleaceae. Seeds. Semliki forest virus / drug effects
  • [MeSH-minor] 1-Butanol / administration & dosage. 1-Butanol / pharmacology. Administration, Oral. Alphavirus Infections / drug therapy. Alphavirus Infections / mortality. Animals. Cardiovirus Infections / drug therapy. Cardiovirus Infections / mortality. Cercopithecus aethiops. Dose-Response Relationship, Drug. Glycosides / administration & dosage. Glycosides / pharmacology. Injections, Intraperitoneal. Iridoids / administration & dosage. Iridoids / pharmacology. Mice. Phytotherapy / methods. Plant Extracts / pharmacology. Vero Cells

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  • (PMID = 16359127.001).
  • [ISSN] 0019-5189
  • [Journal-full-title] Indian journal of experimental biology
  • [ISO-abbreviation] Indian J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Glycosides; 0 / Iridoids; 0 / Plant Extracts; 8PJ61P6TS3 / 1-Butanol
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9. Okada H, Attanucci J, Tahara H, Pollack IF, Bozik ME, Chambers WH, Lotze MT: Characterization and transduction of a retroviral vector encoding human interleukin-4 and herpes simplex virus-thymidine kinase for glioma tumor vaccine therapy. Cancer Gene Ther; 2000 Mar;7(3):486-94
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  • [Title] Characterization and transduction of a retroviral vector encoding human interleukin-4 and herpes simplex virus-thymidine kinase for glioma tumor vaccine therapy.
  • Vaccination with cytokine-transduced tumor cells represents a potentially important approach to the treatment of central nervous system tumors.
  • We have recently demonstrated the therapeutic efficacy of tumor cell vaccines expressing the murine interleukin 4 (IL-4) and the herpes simplex virus-thymidine kinase in a rat brain tumor model in which nonirradiated vaccine cells can be eliminated by the subsequent administration of ganciclovir.
  • An MFG-based retroviral vector was used to generate the recombinant retrovirus, TFG-hIL4-Neo-Tk, in which a long terminal repeat-driven polycistronic transcript encodes three cDNAs that are linked and coexpressed using two intervening internal ribosome entry site fragments from the encephalomyocarditis virus.
  • These data demonstrate the suitability of the TFG-hIL4-Neo-Tk vector for therapeutic studies of cytokine-transduced autologous tumor vaccination in patients with malignant gliomas.
  • [MeSH-major] Cancer Vaccines / genetics. Encephalomyocarditis virus / genetics. Genetic Vectors / therapeutic use. Glioma / therapy. Interleukin-4 / genetics. Simplexvirus / genetics. Thymidine Kinase / genetics. Transfection
  • [MeSH-minor] Animals. Cell Line. Ganciclovir / toxicity. Glial Fibrillary Acidic Protein / biosynthesis. Humans. Lymphocyte Activation. Mice. Phorbol Esters / pharmacology. Rats. Tumor Cells, Cultured / drug effects

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  • (PMID = 10766355.001).
  • [ISSN] 0929-1903
  • [Journal-full-title] Cancer gene therapy
  • [ISO-abbreviation] Cancer Gene Ther.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1KO8-CA70298; United States / NCI NIH HHS / CA / CA68550
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Cancer Vaccines; 0 / Glial Fibrillary Acidic Protein; 0 / Phorbol Esters; 207137-56-2 / Interleukin-4; 20839-06-9 / phorbol-12-myristate; EC 2.7.1.21 / Thymidine Kinase; P9G3CKZ4P5 / Ganciclovir
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10. Olson EJ, Lindgren BR, Carlson CS: Effects of long-term estrogen replacement therapy on bone turnover in periarticular tibial osteophytes in surgically postmenopausal cynomolgus monkeys. Bone; 2008 May;42(5):907-13
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  • [Title] Effects of long-term estrogen replacement therapy on bone turnover in periarticular tibial osteophytes in surgically postmenopausal cynomolgus monkeys.
  • The aims of the present study were to assess the effects of long-term estrogen replacement therapy (ERT) on size and indices of bone turnover in periarticular osteophytes in ovariectomized cynomolgus monkeys and to compare dynamic indices of bone turnover in osteophyte bone with those of subchondral bone (SCB) and epiphyseal/metaphyseal cancellous (EMC) bone.
  • One hundred sixty-five adult female cynomolgus macaques were bilaterally ovariectomized and randomly divided into three age- and weight-matched treatment groups for a 36-month treatment period.
  • Group 1 (OVX control) received no treatment, Group 2 (SPE) received soy phytoestrogens, and Group 3 (ERT) received conjugated equine estrogens in the diet; all monkeys were labeled with calcein before necropsy.
  • A midcoronal, plastic-embedded section of the right proximal tibia from 20 randomly selected animals per treatment group was examined histologically.
  • Forty-nine of the sections (OVX control, n=16; SPE, n=16; ERT, n=17) contained lateral abaxial osteophytes, and static and dynamic histomorphometry measurements were taken from osteophyte bone, SCB from the lateral tibial plateau, and EMC bone.
  • The bone volume, trabecular number, and trabecular thickness in osteophyte bone were considerably higher than in EMC bone; whereas, trabecular separation was considerably lower in osteophyte bone.
  • In all three treatment groups, BS/BV was significantly lower in osteophyte bone vs. EMC bone and significantly higher in osteophyte bone vs. lateral SCB.
  • We conclude that osteophyte area and static and dynamic histomorphometry parameters within periarticular tibial osteophytes in ovariectomized cynomolgus monkeys are not significantly influenced by long-term ERT, but that site differences in static and dynamic bone histomorphometry parameters exist, particularly between EMC and osteophyte bone.

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  • (PMID = 18291743.001).
  • [ISSN] 8756-3282
  • [Journal-full-title] Bone
  • [ISO-abbreviation] Bone
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / R01 RR014099; United States / NCRR NIH HHS / RR / RR014099-13; United States / NIH HHS / OD / T32 OD010993; United States / NCRR NIH HHS / RR / R01 RR014099-13; United States / NCRR NIH HHS / RR / RR18719; United States / NCRR NIH HHS / RR / RR14099; United States / NCRR NIH HHS / RR / T32 RR018719; United States / NCRR NIH HHS / RR / RR018719-03; United States / NCRR NIH HHS / RR / T32 RR018719-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 0 / Estrogens; 0 / Estrogens, Conjugated (USP); 0 / Phytoestrogens
  • [Other-IDs] NLM/ NIHMS47964; NLM/ PMC2435307
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11. Hartley C, Hartley M, Pardoe I, Knight A: Ionic Contra-Viral Therapy (ICVT); a new approach to the treatment of DNA virus infections. Arch Virol; 2006 Dec;151(12):2495-501
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  • [Title] Ionic Contra-Viral Therapy (ICVT); a new approach to the treatment of DNA virus infections.
  • There was normal replication of the RNA virus encephalomyocarditis virus.
  • Antiviral activities of both drugs were influenced by extracellular K(+).
  • Targeting the host cell in this way is fundamentally different to other antiviral drug developments to date and we propose the descriptive term Ionic Contra Viral Therapy (ICVT) for the purpose of definition.
  • [MeSH-major] Antiviral Agents / therapeutic use. DNA Virus Infections / drug therapy. Digoxin / therapeutic use. Furosemide / therapeutic use. Oligonucleotides, Antisense / therapeutic use
  • [MeSH-minor] DNA Viruses / drug effects. DNA Viruses / isolation & purification. Humans. Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors. Sodium-Potassium-Exchanging ATPase / metabolism. Viral Plaque Assay. Virus Replication / drug effects

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  • (PMID = 16932984.001).
  • [ISSN] 0304-8608
  • [Journal-full-title] Archives of virology
  • [ISO-abbreviation] Arch. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Oligonucleotides, Antisense; 73K4184T59 / Digoxin; 7LXU5N7ZO5 / Furosemide; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase
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12. Schmid B, Warnecke A, Fichtner I, Jung M, Kratz F: Development of albumin-binding camptothecin prodrugs using a Peptide positional scanning library. Bioconjug Chem; 2007 Nov-Dec;18(6):1786-99
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  • Designing truly tumor-specific prodrugs remains a challenge in the field of cancer chemotherapy.
  • Our screening experiments at pH 7.4 revealed that Met, Leu, and Lys were preferred amino acids in the position P(1) and Tyr, Phe, and Met in P(2), whereas in P(3) and P(4), the cleavage profiles were less characteristic.
  • On the basis of these results, we developed albumin-binding camptothecin (CPT) prodrugs of the general formula EMC-Arg-P(4)-P(3)-P(2)-P(1)-Ala-CPT (EMC = 6-maleimidocaproic acid) that incorporated two peptide linkers: H-Arg-Ala-Phe-Met-OH and H-Arg-Phe-Tyr-Met-OH (P(4)-P(3)-P(2)-P(1)).
  • Incubation studies with homogenates of HT-29 colon tumor tissue and murine spleen, liver, and kidneys demonstrated cleavage of the peptide linker with CPT-peptide derivatives and CPT being the major cleavage products.
  • Although the peptide sequence is not selectively cleaved in colon tumors, an in vivo study in a HT-29 xenograft model showed that the prodrug EMC-Arg-Arg-Ala-Phe-Met-Ala-CPT demonstrated enhanced antitumor efficacy when compared to CPT [( T/ C max: 17% for the prodrug (2 x 12.5 mg/kg CPT equivalents) and 40% for CPT (3 x 12.5 mg/kg)].

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  • (PMID = 17915955.001).
  • [ISSN] 1043-1802
  • [Journal-full-title] Bioconjugate chemistry
  • [ISO-abbreviation] Bioconjug. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins; 0 / Peptide Library; 0 / Prodrugs; XT3Z54Z28A / Camptothecin
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13. Drilon AD, Popat S, Bhuchar G, D'Adamo DR, Keohan ML, Fisher C, Antonescu CR, Singer S, Brennan MF, Judson I, Maki RG: Extraskeletal myxoid chondrosarcoma: a retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy. Cancer; 2008 Dec 15;113(12):3364-71
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  • [Title] Extraskeletal myxoid chondrosarcoma: a retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy.
  • BACKGROUND: Extraskeletal myxoid chondrosarcoma (EMC) is a genetically distinct sarcoma with a propensity for local recurrence and metastasis despite an indolent course.
  • To the authors' knowledge, there are limited data examining chemotherapy outcomes as a guide to therapeutic decisions for unresectable disease.
  • METHODS: The clinical behavior and treatment responses of 87 patients with EMC who were seen at 2 institutions between 1975 and 2008 were examined.
  • RESULTS: The median age of the patients at the time of diagnosis was 49.5 years, with a male-to-female ratio of 2:1.
  • For patients presenting without metastases, 37% developed local recurrence (median time of 3.3 years) and 26% developed distal recurrence (median time of 3.2 years).
  • Twenty-one patients received 32 evaluable courses of chemotherapy.
  • The median time to disease progression while receiving chemotherapy was 5.2 months.
  • The best physician-assessed response to chemotherapy was stable disease for at least 6 months in 25% of patients, stable disease for <6 months in 41% of patients, and disease progression in 34% of patients.
  • CONCLUSIONS: This retrospective review highlights the poor response rate to chemotherapy and emphasizes aggressive control of localized disease as the primary approach to management.
  • Although there are biases inherent in retrospective analyses, these data provide a benchmark for time to disease progression for the study of new agents for the treatment of patients with this diagnosis.
  • [MeSH-major] Chondrosarcoma / drug therapy. Chondrosarcoma / surgery. Soft Tissue Neoplasms / drug therapy. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Disease-Free Survival. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 18951519.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01 CA047179-15A2; United States / NCI NIH HHS / CA / P01 CA047179-18; United States / NCI NIH HHS / CA / P01-CA47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS139129; NLM/ PMC2779719
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14. Kato J, Kato N, Moriyama M, Goto T, Taniguchi H, Shiratori Y, Omata M: Interferons specifically suppress the translation from the internal ribosome entry site of hepatitis C virus through a double-stranded RNA-activated protein kinase-independent pathway. J Infect Dis; 2002 Jul 15;186(2):155-63
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  • Interferon (IFN) therapy is used worldwide as the best available treatment for hepatitis C virus (HCV) infection; however, little is known about how IFN or other drugs work against liver diseases.
  • The effect of 6 drugs (glycyrrhizin, ursodeoxycholic acid, ribavirin, methylprednisolone, IFN-alpha, and IFN-beta) on HCV RNA translation from the HCV internal ribosome entry site (IRES) was investigated, using a bicistronic reporter containing the HCV IRES.
  • In contrast to HCV IRES, IFN did not suppress either foot-and-mouth disease virus IRES-dependent or encephalomyocarditis virus IRES-dependent translation more than it suppressed cap-dependent translation.
  • [MeSH-major] Anti-Infective Agents / pharmacology. Hepacivirus / drug effects. Interferons / pharmacology. Ribosomes / drug effects
  • [MeSH-minor] Antiviral Agents / pharmacology. Autoantigens / biosynthesis. Blotting, Western. Cholagogues and Choleretics / pharmacology. Encephalomyocarditis virus / metabolism. Foot-and-Mouth Disease Virus / metabolism. Glucocorticoids / pharmacology. Glycyrrhizic Acid / pharmacology. Humans. Methylprednisolone / pharmacology. Protein Biosynthesis / drug effects. Protein Biosynthesis / physiology. RNA, Double-Stranded / genetics. RNA, Double-Stranded / metabolism. RNA, Viral / genetics. RNA, Viral / metabolism. Ribavirin / pharmacology. Ribonucleoproteins / biosynthesis. Tumor Cells, Cultured. Ursodeoxycholic Acid / pharmacology

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  • (PMID = 12134250.001).
  • [ISSN] 0022-1899
  • [Journal-full-title] The Journal of infectious diseases
  • [ISO-abbreviation] J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Antiviral Agents; 0 / Autoantigens; 0 / Cholagogues and Choleretics; 0 / Glucocorticoids; 0 / RNA, Double-Stranded; 0 / RNA, Viral; 0 / Ribonucleoproteins; 0 / SS-B antigen; 49717AWG6K / Ribavirin; 6FO62043WK / Glycyrrhizic Acid; 724L30Y2QR / Ursodeoxycholic Acid; 9008-11-1 / Interferons; X4W7ZR7023 / Methylprednisolone
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15. Lam R, Farrell R, Aziz T, Gibbs E, Giovannoni G, Grossberg S, Oger J: Validating parameters of a luciferase reporter gene assay to measure neutralizing antibodies to IFNbeta in multiple sclerosis patients. J Immunol Methods; 2008 Jul 31;336(2):113-8
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  • Neutralizing antibodies (NAbs) can occur in some multiple sclerosis (MS) patients receiving interferon beta (IFNbeta) therapy.
  • NAbs reduce drug bioavailabity and high NAb titers reduce drug efficacy.
  • We assayed 163 sera from IFNbeta treated MS patients with an optimized luciferase method and compared the results to those obtained with the reference cytopathic effect (CPE) method using A549 cells and an encephalomyocarditis virus (EMCV).
  • The luciferase assay is reliable, appropriately sensitive and requires less time than the currently available NAb methods.
  • [MeSH-major] Antibodies / blood. Biological Assay / methods. Enzyme-Linked Immunosorbent Assay / methods. Interferon-beta / immunology. Multiple Sclerosis / immunology
  • [MeSH-minor] Cell Line. Cytopathogenic Effect, Viral. Encephalomyocarditis virus / physiology. Genes, Reporter. Humans. Luciferases / genetics. Luciferases / metabolism. Neutralization Tests. Reference Values. Sensitivity and Specificity

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  • (PMID = 18511063.001).
  • [ISSN] 0022-1759
  • [Journal-full-title] Journal of immunological methods
  • [ISO-abbreviation] J. Immunol. Methods
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 77238-31-4 / Interferon-beta; EC 1.13.12.- / Luciferases
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16. François C, Duverlie G, Rebouillat D, Khorsi H, Castelain S, Blum HE, Gatignol A, Wychowski C, Moradpour D, Meurs EF: Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis. J Virol; 2000 Jun;74(12):5587-96
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  • Hepatitis C virus (HCV) of genotype 1 is the most resistant to interferon (IFN) therapy.
  • IFN-treated, induced UHCV cells were found to better support the growth of encephalomyocarditis virus (EMCV) than IFN-treated, uninduced cells.
  • The effect of expression of HCV proteins on PKR activity was assayed in a reporter assay and by direct analysis of the in vivo phosphorylation of eIF2alpha after treatment of cells with poly(I)-poly(C).
  • [MeSH-minor] 2',5'-Oligoadenylate Synthetase / biosynthesis. 2',5'-Oligoadenylate Synthetase / metabolism. Cytoplasm / chemistry. Cytoplasm / enzymology. Encephalomyocarditis virus / drug effects. Encephalomyocarditis virus / physiology. Endoplasmic Reticulum / chemistry. Eukaryotic Initiation Factor-2 / metabolism. Gene Expression / drug effects. Gene Expression Regulation, Viral / drug effects. Humans. Microscopy, Confocal. Phosphorylation / drug effects. Poly I-C / pharmacology. Polyproteins / biosynthesis. Polyproteins / genetics. Polyproteins / metabolism. Protein Biosynthesis / drug effects. Tetracycline / pharmacology. Tumor Cells, Cultured. Viral Nonstructural Proteins / biosynthesis. Viral Nonstructural Proteins / genetics. Viral Nonstructural Proteins / metabolism

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  • (PMID = 10823866.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Eukaryotic Initiation Factor-2; 0 / NS-5 protein, hepatitis C virus; 0 / Polyproteins; 0 / Viral Nonstructural Proteins; 0 / Viral Proteins; 24939-03-5 / Poly I-C; 9008-11-1 / Interferons; EC 2.7.11.1 / eIF-2 Kinase; EC 2.7.7.- / 2',5'-Oligoadenylate Synthetase; F8VB5M810T / Tetracycline
  • [Other-IDs] NLM/ PMC112046
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17. Han K, Sun YJ, Shen Z, Zhang JJ, Lin F, Zhao H, Meerani S, Yao Y: Extraskeletal myxoid chondrosarcoma: a case report of complete remission by chemotherapy and review of the literature. BMJ Case Rep; 2010;2010
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  • [Title] Extraskeletal myxoid chondrosarcoma: a case report of complete remission by chemotherapy and review of the literature.
  • Extraskeletal myxoid chondrosarcoma is a rare soft tissue sarcoma.
  • The response rate to chemotherapy has been very poor; with the exception of one reported case which showed promising results, overall results are disappointing because no significant radiologic or clinical responses have been noted with chemotherapy.
  • Here we report the case of a 15-year-old girl who presented with extraskeletal myxoid chondrosarcoma in the sacrococcygeal region which was regarded as unresectable.
  • After four cycles of chemotherapy the mass showed complete remission which has lasted >6 months.

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  • (PMID = 22315646.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029822
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18. Yi JW, Park YK, Choi YM, Hong HP, Chang SG: Bulbous urethra involved in perineal extraskeletal myxoid chondrosarcoma in a child. Int J Urol; 2004 Jun;11(6):436-9
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  • [Title] Bulbous urethra involved in perineal extraskeletal myxoid chondrosarcoma in a child.
  • Extraskeletal myxoid chondrosarcoma is a rare soft-tissue sarcoma that usually occurs in deep soft tissues, especially those of the proximal extremities and limb girdles, but is rare in children.
  • The patient was treated with surgical excision and urethroplasty followed by combination chemotherapy.
  • [MeSH-major] Chondrosarcoma / pathology. Perineum / pathology. Soft Tissue Neoplasms / pathology. Urethral Neoplasms / pathology

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  • (PMID = 15157219.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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19. Cohen L, Dank G, Milgram J: Non-skeletal multicentric chondrosarcoma in the hindlimb of a dog. J Small Anim Pract; 2010 Oct;51(10):553-7
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  • [Title] Non-skeletal multicentric chondrosarcoma in the hindlimb of a dog.
  • Multiple soft tissue masses were palpable within the hindlimb muscles.
  • A tentative diagnosis of sarcoma was made on fine needle aspiration.
  • A computed tomography scan of the hindlimb and thorax confirmed the presence and location of the masses, none of which were associated with the bones of the hindlimb.
  • A diagnosis of chondrosarcoma was confirmed on histopathology with a final diagnosis of extraskeletal chondrosarcoma.
  • A high, hindlimb amputation was performed, and chemotherapy was initiated.
  • [MeSH-major] Bone Neoplasms / veterinary. Chondrosarcoma / veterinary. Dog Diseases / pathology
  • [MeSH-minor] Amputation / veterinary. Animals. Dogs. Female. Hindlimb. Lameness, Animal / pathology. Lameness, Animal / surgery. Neoplasm Metastasis

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  • [Copyright] © 2010 British Small Animal Veterinary Association.
  • (PMID = 21029099.001).
  • [ISSN] 1748-5827
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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20. Chow WA: Update on chondrosarcomas. Curr Opin Oncol; 2007 Jul;19(4):371-6
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  • [Title] Update on chondrosarcomas.
  • PURPOSE OF REVIEW: This paper reviews recent molecular, biologic, developmental therapeutic, and clinical findings in conventional and variant chondrosarcomas.
  • RECENT FINDINGS: The prognosis of chondrosarcomas traditionally correlates with histologic grade and adequacy of surgery.
  • Translational research has validated platelet-derived growth factor receptor, estrogen signaling, matrix metalloproteinase-1, histone deacetylase, methylthioadenosine phosphorylase, and vascular endothelial growth factor-A as potential therapeutic targets.
  • Molecular studies have established that extraskeletal myxoid chondrosarcoma is a unique entity defined by the presence of a fusion gene between the orphan nuclear receptor, CHN/NOR1, and a promiscuous partner, most commonly EWSR1.
  • Clinical studies have shown that development of second malignancies is an uncommon but real risk for chondrosarcoma survivors; the benefit of chemotherapy for dedifferentiated chondrosarcomas remains questionable; and late recurrences of clear cell chondrosarcomas emphasize the need for long-term follow up.
  • SUMMARY: Chondrosarcomas are a heterogeneous group of bone and soft tissue tumors.
  • Recent advances in molecular diagnostics, pathobiology, and developmental therapeutics will aid both scientists and clinicians in improving the classification and therapy of this diverse family of cartilaginous tumors.
  • [MeSH-major] Bone Neoplasms. Chondrosarcoma

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  • (PMID = 17545802.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 53
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21. Fabrizi F, Colucci P, Ponticelli C, Locatelli F: Kidney and liver involvement in cryoglobulinemia. Semin Nephrol; 2002 Jul;22(4):309-18
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  • Mixed cryoglobulins (MCs) are composed of a polyclonal immunoglobulin G (IgG) bound to another immunoglobulin that acts as an anti-IgG rheumatoid factor; 2 types of MCs can be identified.
  • The great majority (up to 90%) of patients with essential MC (EMC) of both types has been related to HCV infection.
  • A well-characterized pattern of glomerular disease termed "cryoglobulinemic glomerulonephritis" is present in individuals with type-II EMCs in serum and IgMk RF being the most frequent monoclonal component.
  • Aspecific and infrequent glomerular lesions occur in EMC patients with type III cryoglobulins.
  • However, cryoglobulinemic GN may have some distinctive features that differentiate it from idiopathic type-I MPGN.
  • Evidence of liver involvement has been found in 60% to 80% of EMC patients.
  • Recent data support the notion that the stage of liver disease in patients with type II or III MC has association with the prevalence of cryoglobulinemia.
  • Few controlled trials have been published on the treatment of HCV-related MC; in addition, the majority of the patients enrolled in these trials had an unclear renal involvement.
  • Interferon (IFN) is an effective drug for the treatment of patients with HCV-associated MC and cryoglobulinemic GN.
  • In the presence of acute cryoglobulinemic GN, IFN does not prevent progression of renal damage; combination therapy with cytotoxic ad anti-inflammatory drugs, and sometimes plasma exchange, is recommended.
  • [MeSH-minor] Antiviral Agents / therapeutic use. Humans. Interferon-alpha / therapeutic use

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  • [Copyright] Copyright 2002, Elsevier Science (USA). All rights reserved.
  • (PMID = 12118396.001).
  • [ISSN] 0270-9295
  • [Journal-full-title] Seminars in nephrology
  • [ISO-abbreviation] Semin. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Interferon-alpha
  • [Number-of-references] 61
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22. Shih WJ, Mitchell B, Magoun S, Wierzbinski B: Localization of (99m)Tc HMDP in an extraskeletal myxoid chondrosarcoma: a case report. J Nucl Med Technol; 2001 Jun;29(2):84-5
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  • [Title] Localization of (99m)Tc HMDP in an extraskeletal myxoid chondrosarcoma: a case report.
  • Extraskeletal myxoid chondrosarcoma of the lower extremity is rare, and slowly progressive.
  • Despite chemotherapy, the patient died 28 mo later.
  • At autopsy, it was confirmed that he had extraskeletal myxoid chondrosarcoma of the right thigh, which had metastasized to the upper arms, left scapula, lungs, pleurae, and right lower quadrant of the abdomen.
  • The myxoid chondroid matrix, a major feature of the extraskeletal myxoid chondrosarcoma, is thought to account for the localization of the bone-imaging agent.
  • [MeSH-major] Chondrosarcoma / radionuclide imaging. Radiopharmaceuticals. Soft Tissue Neoplasms / radionuclide imaging. Technetium Tc 99m Medronate

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  • (PMID = 11376100.001).
  • [ISSN] 0091-4916
  • [Journal-full-title] Journal of nuclear medicine technology
  • [ISO-abbreviation] J Nucl Med Technol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 72945-61-0 / technetium Tc 99m hydroxymethylene diphosphonate; X89XV46R07 / Technetium Tc 99m Medronate
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23. Valk GD, Renders CM, Kriegsman DM, Newton KM, Twisk JW, van Eijk JT, van der Wal G, Wagner EH: Quality of care for patients with type 2 diabetes mellitus in the Netherlands and the United States: a comparison of two quality improvement programs. Health Serv Res; 2004 Aug;39(4 Pt 1):709-25
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  • [Title] Quality of care for patients with type 2 diabetes mellitus in the Netherlands and the United States: a comparison of two quality improvement programs.
  • STUDY SETTING: Primary care in the ExtraMural Clinic (EMC) of the Department of General Practice of the Vrije Universiteit in Amsterdam, the Netherlands, and the Group Health Cooperative (GHC), a group-model health maintenance organization (HMO) in western Washington State in the United States.
  • Only the Dutch program (EMC) included guidelines on the structure of diabetes care and a recall system.
  • DATA COLLECTION: Included were 379 EMC patients, and 2,119 GHC patients with type 2 diabetes mellitus.
  • PRINCIPAL FINDINGS: In the EMC process outcomes and glycemic control improved more than at GHC, however, GHC had better baseline measures.
  • During follow-up, intensification of pharmacotherapy was noted at both sites.
  • [MeSH-major] Diabetes Mellitus, Type 2 / therapy. Family Practice / standards. Health Maintenance Organizations / standards. Health Services Accessibility / standards. Outpatient Clinics, Hospital / standards. Quality Assurance, Health Care / organization & administration
  • [MeSH-minor] Aged. Blood Glucose / metabolism. Cohort Studies. Cultural Characteristics. Female. Health Services Needs and Demand. Humans. Longitudinal Studies. Male. Middle Aged. Netherlands. Outcome Assessment (Health Care). Patient Satisfaction / statistics & numerical data. Time Factors. Washington


24. Zhang J, Yamada O, Sakamoto T, Yoshida H, Araki H, Shimotohno K: Exploiting cis-acting replication elements to direct hepatitis C virus-dependent transgene expression. J Virol; 2005 May;79(10):5923-32
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  • [Title] Exploiting cis-acting replication elements to direct hepatitis C virus-dependent transgene expression.
  • We describe here a novel targeting gene therapy strategy to direct gene expression responsive to hepatitis C virus (HCV).
  • The goal was approached by engineering a construct containing the antisense sequence of the transgene and internal ribosome entry site of encephalomyocarditis virus flanked by 5'- and 3'-end sequences of HCV cDNA that contain cis-acting replication elements.
  • [MeSH-minor] Adenoviridae / genetics. Adenoviridae / metabolism. Cell Line. Cell Line, Transformed. Cell Survival / drug effects. Cytopathogenic Effect, Viral / drug effects. DNA Polymerase II / biosynthesis. DNA Polymerase II / genetics. Encephalomyocarditis virus / genetics. Flucytosine / pharmacology. Gene Expression Regulation, Viral. Genes, Transgenic, Suicide. Genetic Therapy / methods. Genetic Vectors. Humans. Luciferases / genetics. RNA, Small Interfering / genetics. RNA, Viral / biosynthesis. Transfection. Viral Nonstructural Proteins / antagonists & inhibitors. Viral Nonstructural Proteins / genetics

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  • (PMID = 15857978.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NS-5 protein, hepatitis C virus; 0 / RNA, Small Interfering; 0 / RNA, Viral; 0 / Viral Nonstructural Proteins; D83282DT06 / Flucytosine; EC 1.13.12.- / Luciferases; EC 2.7.7.- / DNA Polymerase II; EC 3.5.4.1 / Cytosine Deaminase
  • [Other-IDs] NLM/ PMC1091670
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25. Huang KF, Tzaan WC, Lin CY: Primary intraspinal mesenchymal chondrosarcoma: a case report and literature review. Chang Gung Med J; 2003 May;26(5):370-6
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  • [Title] Primary intraspinal mesenchymal chondrosarcoma: a case report and literature review.
  • Mesenchymal chondrosarcomas are rare malignant tumors of the bone and soft tissue.
  • Extraskeletal mesenchymal chondrosarcomas, especially those that arise in the central nervous system, are even rarer.
  • Therapeutic experience with primary spinal mesenchymal chondrosarcomas is also extremely limited.
  • A T1-weighted magnetic resonance image revealed a hypointense tumor located at the T8 level.
  • Microscopic examination and immunohistochemical studies confirmed the diagnosis of mesenchymal chondrosarcoma.
  • Spinal irradiation and chemotherapy were also administered for prevention of local recurrence and metastasis.
  • Herein, we review the 22 cases of primary intraspinal mesenchymal chondrosarcomas in the literature and discuss their clinical presentations, pathology, imaging studies, treatments, and outcomes.
  • [MeSH-major] Chondrosarcoma, Mesenchymal / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 12934855.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 18
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26. Benvenuti E, Cecchi F, Colombini A, Gori G: Extradural motor cortex stimulation as a method to treat advanced Parkinson's disease: new perspectives in geriatric medicine. Aging Clin Exp Res; 2006 Aug;18(4):347-8
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  • Motor fluctuations not controlled by pharmacological therapy are often encountered in long-term Parkinson's disease (PD).
  • Neurosurgery treatment represented by deep brain stimulation (DBS) was considered a valid alternative to pharmacological treatment.
  • Recently it has been suggested that extradural motor cortex stimulation (EMCS) could be a valid cost-effective alternative to DBS to control motor symptoms in patients affected by Parkinson's disease.
  • The relevant non-invasive surgical technique makes this treatment particularly indicated in geriatric patients.
  • Brain atrophy, cognitive impairment, psychiatric symptoms are not an absolute contraindication to the treatment.
  • We submitted to EMCS an outpatient afferent to our geriatric department, a woman 68 yrs old.
  • If our findings will be confirmed in larger series, a new dimension will be added to the treatment of PD.
  • [MeSH-major] Electric Stimulation Therapy / methods. Motor Cortex / physiology. Parkinson Disease / physiopathology. Parkinson Disease / therapy
  • [MeSH-minor] Aged. Aged, 80 and over. Disease Progression. Geriatrics / methods. Humans. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / methods. Severity of Illness Index. Treatment Outcome

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  • (PMID = 17063072.001).
  • [ISSN] 1594-0667
  • [Journal-full-title] Aging clinical and experimental research
  • [ISO-abbreviation] Aging Clin Exp Res
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Italy
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27. Matsumori A, Nunokawa Y, Yamaki A, Yamamoto K, Hwang MW, Miyamoto T, Hara M, Nishio R, Kitaura-Inenaga K, Ono K: Suppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF-kappaB inhibitor. Eur J Heart Fail; 2004 Mar 1;6(2):137-44
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  • In addition to protecting mice against lethal endotoxemia, SUN C8079 prevented the development of myocarditis due to the encephalomyocarditis virus (EMCV), and inhibited the expressions of proinflammatory cytokines and the iNOS gene in cardiac tissues.
  • CONCLUSION: These findings suggest that the activation of NF-kappaB plays an important role in the pathogenesis of endotoxemia and viral myocarditis, and that the NF-kappaB inhibitor, SUN C8079, may be therapeutic in these disorders.
  • [MeSH-minor] Animals. Cardiovirus Infections / drug therapy. Cardiovirus Infections / prevention & control. Cardiovirus Infections / virology. Cell Nucleus / metabolism. Cells, Cultured. DNA, Complementary / metabolism. Encephalomyocarditis virus. Female. Gene Expression Regulation / drug effects. Humans. In Vitro Techniques. Interleukin-1 / biosynthesis. Interleukin-1 / genetics. Lipopolysaccharides / toxicity. Male. Mice. Mice, Inbred BALB C. Mice, Inbred DBA. Nitric Oxide Synthase Type II. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 14984720.001).
  • [ISSN] 1388-9842
  • [Journal-full-title] European journal of heart failure
  • [ISO-abbreviation] Eur. J. Heart Fail.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Interleukin-1; 0 / Lipopolysaccharides; 0 / NF-kappa B; 0 / Piperidines; 0 / RNA, Messenger; 0 / SUN C8079; 0 / Tumor Necrosis Factor-alpha; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.13.39 / Nos2 protein, mouse
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28. Gao X, Peng L, Adhikari CM, Lin J, Zuo Z: Spironolactone reduced arrhythmia and maintained magnesium homeostasis in patients with congestive heart failure. J Card Fail; 2007 Apr;13(3):170-7
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  • METHODS AND RESULTS: We randomized 116 consecutive patients with CHF into placebo control group (n = 58) and spironolactone group (20 mg daily, n = 58) in addition to conventional therapy.
  • Plasma magnesium concentration (PMC), erythrocyte magnesium concentration (EMC), and erythrocyte magnesium efflux were not different between the 2 groups of patients before treatment.
  • Compared with control patients, patients treated with spironolactone for 6 months had increased PMC and EMC and decreased erythrocyte magnesium efflux.
  • Patients on spironolactone therapy also had a marked decrease of 24-hour mean heart rate, ventricular and atrial premature beats, and the risk of atrial fibrillation/flutter.
  • Pooled data from the 116 patients showed that patients with a higher EMC or a lower sodium-dependent erythrocyte magnesium efflux had a slower heart rate, fewer ventricular premature beats, and a lower risk of atrial fibrillation/flutter.
  • [MeSH-major] Arrhythmias, Cardiac / prevention & control. Heart Failure / complications. Heart Failure / drug therapy. Magnesium Deficiency / complications. Magnesium Deficiency / drug therapy. Mineralocorticoid Receptor Antagonists / therapeutic use. Spironolactone / therapeutic use
  • [MeSH-minor] Dose-Response Relationship, Drug. Double-Blind Method. Erythrocytes / metabolism. Exercise Tolerance / drug effects. Female. Heart Function Tests / drug effects. Homeostasis / drug effects. Humans. Magnesium / blood. Male. Middle Aged. Potassium / blood. Treatment Outcome

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  • (PMID = 17448413.001).
  • [ISSN] 1532-8414
  • [Journal-full-title] Journal of cardiac failure
  • [ISO-abbreviation] J. Card. Fail.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mineralocorticoid Receptor Antagonists; 27O7W4T232 / Spironolactone; I38ZP9992A / Magnesium; RWP5GA015D / Potassium
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29. Graeser R, Chung DE, Esser N, Moor S, Schächtele C, Unger C, Kratz F: Synthesis and biological evaluation of an albumin-binding prodrug of doxorubicin that is cleaved by prostate-specific antigen (PSA) in a PSA-positive orthotopic prostate carcinoma model (LNCaP). Int J Cancer; 2008 Mar 1;122(5):1145-54
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  • We have recently investigated a macromolecular prodrug strategy for improved cancer chemotherapy based on 2 features: (i) rapid and selective binding of thiol-reactive prodrugs to the cysteine-34 position of endogenous albumin after intravenous administration, and (ii) enzymatic release of the albumin-bound drug at the tumor site (Mansour et al., Cancer Res 2003, 63, 4062-4066).
  • In this work, we describe an albumin-binding prodrug, EMC-Arg-Ser-Ser-Tyr-Tyr--Ser-Arg-DOXO [EMC: epsilon-Maleimidocaproic acid; DOXO = doxorubicin; X = amino acid] that is cleaved by PSA.
  • Incubation studies with PSA and tumor homogenates from PSA-positive tumors (LNCaP) demonstrated that the albumin-bound form of the prodrug was efficiently cleaved by PSA at the P(1)-P' (1) scissile bond releasing the doxorubicin dipeptide H-Ser-Arg-DOXO, which was further degraded to doxorubicin as the final cleavage product.
  • In cell culture experiments, the prodrug was approximately 100-fold less active against LNCaP cells than the free drug.
  • Doxorubicin treatment at a dose of 2 x 4 mg/kg caused significant weight loss and mortality (-25%), and did not result in a significant antitumor response at the end of the experiment.
  • [MeSH-major] Albumins / therapeutic use. Antibiotics, Antineoplastic / therapeutic use. Doxorubicin / therapeutic use. Prodrugs / chemical synthesis. Prostate-Specific Antigen / metabolism. Prostatic Neoplasms / drug therapy

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17973264.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins; 0 / Antibiotics, Antineoplastic; 0 / Prodrugs; 80168379AG / Doxorubicin; EC 3.4.21.77 / Prostate-Specific Antigen
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30. Ibrahimi A, Vande Velde G, Reumers V, Toelen J, Thiry I, Vandeputte C, Vets S, Deroose C, Bormans G, Baekelandt V, Debyser Z, Gijsbers R: Highly efficient multicistronic lentiviral vectors with peptide 2A sequences. Hum Gene Ther; 2009 Aug;20(8):845-60
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  • Gene discovery and gene therapy call for advanced technologies to reliably assess gene expression; efficient coupling of gene expression to the expression of reporter genes is critical.
  • Although the encephalomyocarditis virus (EMCV) IRES yielded functional bicistronic vectors, the expression level of the reporter downstream of IRES was consistently lower than that of the upstream transgene.
  • The intrinsic "cleavage" property of the peptide 2A sequences allows each protein to be produced at proportional levels, opening ample possibilities for functional genomics and future gene therapeutic applications.
  • [MeSH-minor] Amino Acid Sequence. Animals. Blotting, Western. Cell Line. Ganciclovir / pharmacology. Gene Expression Regulation / drug effects. Genes, Reporter. Green Fluorescent Proteins / metabolism. Humans. Mice. Plasmids / genetics. Subcellular Fractions / drug effects. Subcellular Fractions / metabolism. Transduction, Genetic

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  • (PMID = 19419274.001).
  • [ISSN] 1557-7422
  • [Journal-full-title] Human gene therapy
  • [ISO-abbreviation] Hum. Gene Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptides; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; P9G3CKZ4P5 / Ganciclovir
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31. Saegusa S, Fei Y, Takahashi T, Sumino H, Moriya J, Kawaura K, Yamakawa J, Itoh T, Morimoto S, Nakahashi T, Iwai K, Matsumoto M, Kanda T: Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression. Cardiovasc Drugs Ther; 2007 Jun;21(3):155-60
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  • PURPOSE: We examined the effects of the angiotensin II receptor type 1 blocker candesartan on myocarditis injury in a murine model of acute myocarditis.
  • We intraperitoneally injected encephalomyocarditis virus in C3H mice, then orally administered candesartan (10 mg/kg/day) or vehicle (control).

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  • (PMID = 17484035.001).
  • [ISSN] 0920-3206
  • [Journal-full-title] Cardiovascular drugs and therapy
  • [ISO-abbreviation] Cardiovasc Drugs Ther
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Angiotensin II Type 1 Receptor Blockers; 0 / Benzimidazoles; 0 / RNA, Messenger; 0 / Tetrazoles; 0 / Tumor Necrosis Factor-alpha; S8Q36MD2XX / candesartan
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32. Liu W, Shimada M, Xiao J, Hu D, Matsumori A: Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis. Life Sci; 2009 Jul 31;85(5-6):235-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MAIN METHODS: Four-week-old male DBA/2 mice were inoculated with 2 pfu of encephalomyocarditis virus (EMCV) and randomized to nifedipine (n=10) or control (n=10) group.
  • [MeSH-major] Calcium Channel Blockers / pharmacology. Cardiovirus Infections / prevention & control. Encephalomyocarditis virus / physiology. Myocarditis / prevention & control. Nifedipine / pharmacology
  • [MeSH-minor] Animals. Biomarkers / metabolism. Collagen Type I / genetics. Collagen Type I / metabolism. Disease Models, Animal. Gene Expression / drug effects. Heart / drug effects. Heart / virology. Interleukin-5 / genetics. Interleukin-5 / metabolism. Male. Mast Cells / drug effects. Mast Cells / enzymology. Mast Cells / pathology. Matrix Metalloproteinases / genetics. Matrix Metalloproteinases / metabolism. Mice. Mice, Inbred DBA. Myocardium / pathology. Necrosis / drug therapy. Polymerase Chain Reaction. RNA, Messenger / metabolism. Stem Cell Factor / genetics. Stem Cell Factor / metabolism. Tryptases / genetics. Tryptases / metabolism. Tumor Necrosis Factor-alpha / genetics. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 19520090.001).
  • [ISSN] 1879-0631
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Calcium Channel Blockers; 0 / Collagen Type I; 0 / Interleukin-5; 0 / RNA, Messenger; 0 / Stem Cell Factor; 0 / Tumor Necrosis Factor-alpha; EC 3.4.21.59 / Tryptases; EC 3.4.24.- / Matrix Metalloproteinases; I9ZF7L6G2L / Nifedipine
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33. Scagnolari C, Vicenzi E, Bellomi F, Stillitano MG, Pinna D, Poli G, Clementi M, Dianzani F, Antonelli G: Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons. Antivir Ther; 2004 Dec;9(6):1003-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons.
  • The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-beta and only weakly sensitive to IFN-alpha and IFN-gamma, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease.
  • [MeSH-major] Interferon Type I / pharmacology. Interferon-gamma / pharmacology. SARS Virus / drug effects. Virus Replication / drug effects
  • [MeSH-minor] Animals. Cercopithecus aethiops. Drug Synergism. GTP-Binding Proteins / genetics. GTP-Binding Proteins / metabolism. Humans. Myxovirus Resistance Proteins. Recombinant Proteins / pharmacology. Vero Cells

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  • (PMID = 15651759.001).
  • [ISSN] 1359-6535
  • [Journal-full-title] Antiviral therapy
  • [ISO-abbreviation] Antivir. Ther. (Lond.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Interferon Type I; 0 / MX1 protein, human; 0 / Myxovirus Resistance Proteins; 0 / Recombinant Proteins; 82115-62-6 / Interferon-gamma; EC 3.6.1.- / GTP-Binding Proteins
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34. Tangjitgamol S, Manusirivithaya S, Lertbutsayanukul C: Adjuvant therapy for early-stage endometrial cancer: a review. Int J Gynecol Cancer; 2007 Sep-Oct;17(5):949-56
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  • [Title] Adjuvant therapy for early-stage endometrial cancer: a review.
  • Most patients with endometrial cancer (EMC) present their symptoms early in their course, leading to an overall favorable outcome.
  • However, some patients who are in early-stage diseases may carry some risk features that would hamper their prognoses.
  • For these early-stage diseases with high risk of recurrences, radiation therapy certainly plays a major role as an adjuvant treatment.
  • To improve the prognoses, other types of adjuvant therapy have been attempted.
  • In this review, various options of adjuvant treatment for this early-stage EMC including radiation therapy, chemotherapy, and hormonal therapy are discussed.
  • [MeSH-major] Carcinoma / therapy. Endometrial Neoplasms / therapy. Neoadjuvant Therapy / methods
  • [MeSH-minor] Female. Humans. Neoplasm Staging

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  • (PMID = 17309664.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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35. Takeda A, Tsuchiya H, Mori Y, Nonomura A, Tomita K: Extraskeletal myxoid chondrosarcoma with multiple skeletal metastases. J Orthop Sci; 2000;5(2):171-4
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  • [Title] Extraskeletal myxoid chondrosarcoma with multiple skeletal metastases.
  • Pulmonary metastases are not unusual in extraskeletal myxoid chondrosarcoma; however, only two patients have been reported with multiple bony metastases.
  • We report here one patient with extraskeletal myxoid chondrosarcoma associated with lung and multiple bony metastases.
  • After chemotherapy, the primary lesion was resected, but lung and multiple bony metastases were found 20 months later.
  • After chemotherapy, the lung metastases were resected, and those in the vertebral bodies were treated with radiotherapy.
  • [MeSH-major] Bone Neoplasms / secondary. Chondrosarcoma / secondary. Lung Neoplasms / secondary
  • [MeSH-minor] Combined Modality Therapy. Femoral Neoplasms / pathology. Femoral Neoplasms / secondary. Femoral Neoplasms / therapy. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Treatment Outcome

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  • (PMID = 10982652.001).
  • [ISSN] 0949-2658
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
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36. Veldhuyzen Van Zanten S, Machado S, Lee J: One-week triple therapy with esomeprazole, clarithromycin and metronidazole provides effective eradication of Helicobacter pylori infection. Aliment Pharmacol Ther; 2003 Jun 1;17(11):1381-7
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  • [Title] One-week triple therapy with esomeprazole, clarithromycin and metronidazole provides effective eradication of Helicobacter pylori infection.
  • AIM: To compare the eradication rates of treatment with esomeprazole, metronidazole and clarithromycin (EMC) vs. omeprazole, metronidazole and clarithromycin (OMC), given for 7 days.
  • OMC treatment was followed by 3 weeks of treatment with 20 mg omeprazole alone; the EMC group received placebo.
  • The eradication of H. pylori was determined by two negative breath tests performed at least 4 and 8 weeks following the completion of treatment.
  • The success rates of EMC/placebo were 76% (144/190) by intention-to-treat and 80% (138/172) by per protocol analysis; for OMC/omeprazole, the rates were 72% (137/189) and 75% (125/167), respectively.
  • The difference between the two treatment groups was not significant.
  • Treatment was well tolerated.
  • [MeSH-major] Anti-Bacterial Agents / administration & dosage. Anti-Ulcer Agents / administration & dosage. Clarithromycin / administration & dosage. Helicobacter Infections / drug therapy. Helicobacter pylori. Metronidazole / administration & dosage. Omeprazole / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Double-Blind Method. Drug Administration Schedule. Drug Therapy, Combination. Esomeprazole. Female. Humans. Male. Middle Aged. Patient Compliance. Treatment Outcome

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  • (PMID = 12786632.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Ulcer Agents; 140QMO216E / Metronidazole; H1250JIK0A / Clarithromycin; KG60484QX9 / Omeprazole; N3PA6559FT / Esomeprazole
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37. Nepomniashchikh TS, Lebedev LR, Riazankin IA, Pozdniakov SG, Gileeva IP, Shchelkunov SN: [Comparative study of variola virus and monkeypox virus interferon-gamma-binding]. Mol Biol (Mosk); 2005 Nov-Dec;39(6):1055-62
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  • Secreted recombinant IFNgammaBPs were isolated from culture medium of infected Sf21 cells through affinity chromatography procedure.
  • Biological activity of the recombinant IFNgammaBPs were studied in the test of protective effect inhibition of hIFNgamma on L68 cells infected with murine encephalomyocarditis virus.
  • A possibility of the elaboration of new therapeutics for anti-hIFNgamma therapy on the base of IFNgammaBPs is discussed.
  • [MeSH-minor] Amino Acid Sequence. Animals. Cell Line. Dose-Response Relationship, Drug. Humans. Molecular Sequence Data. Protein Binding. Recombinant Proteins / genetics. Recombinant Proteins / metabolism. Recombinant Proteins / pharmacology

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  • (PMID = 16358743.001).
  • [ISSN] 0026-8984
  • [Journal-full-title] Molekuliarnaia biologiia
  • [ISO-abbreviation] Mol. Biol. (Mosk.)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Recombinant Proteins; 0 / Viral Proteins; 82115-62-6 / Interferon-gamma
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