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1. Mosqueda Taylor A, Meneses García A, Ruíz Godoy Rivera LM, Suárez Roa Mde L, Luna Ortiz K: Malignant odontogenic tumors. A retrospective and collaborative study of seven cases. Med Oral; 2003 Mar-Apr;8(2):110-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There were six odontogenic carcinomas (two malignant ameloblastomas, two clear cell odontogenic carcinomas, one primary intraosseous carcinoma and one carcinoma arising in an odontogenic cyst) and one ameloblastic fibrosarcoma.
  • Clear cell odontogenic carcinomas occurred in the canine-premolar region, one in the maxilla and one in the mandible (one ia a man and one in a woman), while the remaining lesions affected the posterior region of the mandible, with a male predominance (4:1), which agrees with previously reported cases.
  • Surgical resection was the treatment employed in all carcinomas, while the ameloblastic fibrosarcoma was treated with chemotherapy due to its large extension, but without favorable response.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adult. Aged. Ameloblastoma / pathology. Female. Humans. Male. Mandibular Neoplasms / pathology. Middle Aged. Odontogenic Cysts / pathology. Prospective Studies. Retrospective Studies

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  • (PMID = 12618671.001).
  • [ISSN] 1137-2834
  • [Journal-full-title] Medicina oral : órgano oficial de la Sociedad Española de Medicina Oral y de la Academia Iberoamericana de Patología y Medicina Bucal
  • [ISO-abbreviation] Med Oral
  • [Language] eng; spa
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Spain
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2. Ram H, Mohammad S, Husain N, Gupta PN: Ameloblastic carcinoma. J Maxillofac Oral Surg; 2010 Dec;9(4):415-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastic carcinoma (AC) is a rare aggressive malignant epithelial odontogenic tumor of the maxillofacial skeleton with a distinct predilection in the mandible.
  • It may appear de novo or originate from a pre-existing ameloblastoma or odontogenic cyst.
  • It exhibits cytological features of ameloblastoma and carcinoma.
  • It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption and tooth mobility.
  • Wide local excision is the treatment of choice.
  • Radiotherapy and chemotherapy have limited role in the treatment of ameloblastic carcinomas.

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  • (PMID = 22190836.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177477
  • [Keywords] NOTNLM ; Ameloblastic carcinoma / Ameloblastoma / Odontogenic tumor
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3. Avon SL, McComb J, Clokie C: Ameloblastic carcinoma: case report and literature review. J Can Dent Assoc; 2003 Oct;69(9):573-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastic carcinoma is a rare malignant lesion with characteristic histologic features and behaviour that dictates a more aggressive surgical approach than that of a simple ameloblastoma.
  • It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption and tooth mobility.
  • The tumour cells resemble the cells seen in ameloblastoma, but they show cytologic atypia.
  • Moreover, they lack the characteristic arrangement seen in ameloblastoma.
  • Wide local excision is the treatment of choice.
  • Radiotherapy and chemotherapy seem to be of limited value for the treatment of ameloblastic carcinomas.
  • At the moment, there are too few reported cases to make a definite recommendation regarding treatment.
  • [MeSH-major] Ameloblastoma / pathology. Maxillary Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 14653932.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 22
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4. Weber K, Damron TA, Frassica FJ, Sim FH: Malignant bone tumors. Instr Course Lect; 2008;57:673-88
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant bone tumors represent a small percentage of cancers nationwide and also are much less common than malignant soft-tissue tumors.
  • The rarity of the condition makes it imperative that orthopaedic surgeons in nononcologic practices are able to recognize the symptoms that suggest a possible bony malignancy to avoid inappropriate or delayed treatment.
  • Rare tumors such as chordoma and adamantinoma have anatomic predilections for the sacrum and tibia, respectively.
  • The primary symptom of a patient with a malignant bone tumor is pain, which often occurs at rest or at night.
  • Patients with a likely malignancy require thorough staging to determine the extent of disease and a well-planned biopsy for accurate diagnosis.
  • Knowledge of specific tumor characteristics and treatment options for osteosarcoma, Ewing's sarcoma, chondrosarcoma, malignant fibrous histiocytoma, chordoma, and adamantinoma is important.
  • Patients with osteosarcoma and resectable Ewing's sarcoma are treated with chemotherapy followed by surgical resection.
  • Secondary sarcomas can occur in previously benign bone lesions and require aggressive treatment.
  • The care of patients with primary malignant bone tumors requires a multidisciplinary approach to treatment.

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  • (PMID = 18399615.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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5. Sabo D, Bernd L, Buchner M, Treiber M, Wannenmacher M, Ewerbeck V, Parsch D: [Intraoperative extracorporeal irradiation and replantation in local treatment of primary malignant bone tumors]. Orthopade; 2003 Nov;32(11):1003-12
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  • [Title] [Intraoperative extracorporeal irradiation and replantation in local treatment of primary malignant bone tumors].
  • In 13 patients with primary malignant bone tumors (10 Ewing's sarcoma, 1 parosteal osteosarcoma, 1 adamantinoma recurrence, and 1 MFH) local therapy was performed as intraoperative extracorporeal irradiation and replantation (IEIR) of the involved bone segment (5 tibia, 2 femur, and 6 pelvis).
  • Of the 13 patients (69%), 9 are alive at the time of the follow-up (5 CDF, 4 AWM(treated)) and 4 patients died of disease (DOD).
  • IEIR must be seen as an extraordinary reconstruction procedure in cases where established procedures such as endoprosthesis, biological reconstructions, or rotationplasties cannot be used or are refused by the patient.
  • [MeSH-minor] Adolescent. Adult. Aged. Ameloblastoma / drug therapy. Ameloblastoma / pathology. Ameloblastoma / radiotherapy. Ameloblastoma / surgery. Child, Preschool. Combined Modality Therapy. Female. Femoral Neoplasms / drug therapy. Femoral Neoplasms / pathology. Femoral Neoplasms / radiotherapy. Femoral Neoplasms / surgery. Follow-Up Studies. Histiocytic Sarcoma / drug therapy. Histiocytic Sarcoma / pathology. Histiocytic Sarcoma / radiotherapy. Histiocytic Sarcoma / surgery. Humans. Male. Neoadjuvant Therapy. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Osteosarcoma / drug therapy. Osteosarcoma / pathology. Osteosarcoma / radiotherapy. Osteosarcoma / surgery. Radiotherapy Dosage. Sarcoma, Ewing / drug therapy. Sarcoma, Ewing / pathology. Sarcoma, Ewing / radiotherapy. Sarcoma, Ewing / surgery. Tibia / pathology. Tibia / surgery

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  • (PMID = 14615850.001).
  • [ISSN] 0085-4530
  • [Journal-full-title] Der Orthopade
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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6. Grünwald V, Le Blanc S, Karstens JH, Weihkopf T, Kuske M, Ganser A, Schöffski P: Metastatic malignant ameloblastoma responding to chemotherapy with paclitaxel and carboplatin. Ann Oncol; 2001 Oct;12(10):1489-91
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  • [Title] Metastatic malignant ameloblastoma responding to chemotherapy with paclitaxel and carboplatin.
  • We report an unusual case of metastatic ameloblastoma, involving lung and pleura. that repeatedly responded to systemic treatment with paclitaxel and carboplatin. suggesting principle chemosensitivity of this rare disease.

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  • (PMID = 11762824.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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7. Kitsoulis P, Charchanti A, Paraskevas G, Marini A, Karatzias G: Adamantinoma. Acta Orthop Belg; 2007 Aug;73(4):425-31
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  • [Title] Adamantinoma.
  • Adamantinoma is one of the rarest low-grade malignant bone tumours, representing less than 1% of them.
  • Fisher in 1913 named this tumour adamantinoma because of its similarity to ameloblastoma of the jaw.
  • Young males are more prone to develop adamantinoma than females.
  • Wide tumour excision and limb salvage reconstruction surgery, or an amputation, are the current surgical treatment options.
  • Radiotherapy and chemotherapy have not been shown to be effective modalities of treatment.
  • [MeSH-major] Adamantinoma. Bone Neoplasms

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  • (PMID = 17939469.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 58
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8. Fujii H, Honoki K, Enomoto Y, Kasai T, Kido A, Amano I, Kumamoto M, Morishita T, Mii Y, Nonomura A, Takakura Y: Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report. Virchows Arch; 2006 Nov;449(5):579-84
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  • [Title] Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report.
  • Recent studies have advocated the genotypic and phenotypic delineation of a novel Ewing's sarcoma histologic variant showing epithelial features defined as "adamantinoma-like Ewing's sarcoma".
  • We described an 18-year-old girl with a primary small round-cell sarcoma of the right tibia showing polyphenotypic differentiation with epithelioid features.
  • The neoplastic cells had mainly round or oval nuclei with fine chromatin with a portion of epithelial arrangements.
  • The diagnosis of the lesion was confirmed as Ewing's sarcoma by the presence of the EWS-FLI1 fusion transcript, and could be defined as the so-called "adamantinoma-like Ewing's sarcoma".
  • After wide excision and high-dose chemotherapy with peripheral blood stem cell transfusion, the patient has been well and continuously event-free for 3 years since the initial diagnosis.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Protein c-fli-1 / genetics. Sarcoma, Ewing / pathology

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  • (PMID = 17016721.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
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9. Abada RL, Kadiri F, Tawfik N, Benchakroun N, Bouchbika Z, Chekkoury AI, Benchakroun Y, Benider A: [Multiple metastases of a mandibular ameloblastoma]. Rev Stomatol Chir Maxillofac; 2005 Jun;106(3):177-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiple metastases of a mandibular ameloblastoma].
  • INTRODUCTION: Ameloblastoma is a benign odontogenic tumor which can be locally aggressive and invasive.
  • Metastases are rare but possible and must be considered as a malignant form of the tumor.
  • OBSERVATION: A 50-year-old woman presented a jugal metastasis of a mandibular ameloblastom which had been treated several times 28 years earlier.
  • Six months after resection of the metastasis, the patient developed multiple cervical node metastases which were removed by radical curettage.
  • Five months later, new metastases developed on the scalp and three months later a voluminous metastasis involving the right hemiface extended to the base of the skull.
  • DISCUSSION: The absence of any histological sign of malignity in the primary tumor and in the metastases, as observed in our patient, is remarkable.
  • The time to development of a metastasis is generally very long and metastases usually remain asymptomatic.
  • Progression is very slow, like for the primary tumor.
  • Several factors predictive of metastasis have been described: female gender, age at onset of primary tumor (2nd to 3rd decade) and multiple local recurrences.
  • There is no standard treatment for metastases.
  • Chemotherapy is not effective.
  • Surgical resection remains the treatment of choice.
  • [MeSH-major] Ameloblastoma / secondary. Mandibular Neoplasms / pathology

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  • (PMID = 15976707.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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10. Jeon DG, Lee SY, Kim JW: Bone primary sarcomas undergone unplanned intralesional procedures - the possibility of limb salvage and their oncologic results. J Surg Oncol; 2006 Dec 1;94(7):592-8
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  • An unplanned surgical excision occurs when tumors are removed without the appropriate preoperative evaluation and consideration for the need to obtain tumor-free margins.
  • Residual tumor tissue as a result of unplanned excision of soft tissue sarcoma is a risk factor for local recurrence.
  • There were 22 (88%) cases of osteosarcomas, 2 (8%) MFH of bone and 1 (4%) adamantinoma.
  • RESULTS: Lung metastasis developed in 6 (24%) cases.
  • Limb salvage procedures are worthwhile in cases whose initial radiographic findings simulate benign lesions, showing favorable response to neoadjuvant chemotherapy.
  • The relative contraindication to the limb salvage is cases with a history of a pathologic fracture and extensive operative fixation.
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Curettage. Female. Humans. Lower Extremity / surgery. Male. Middle Aged. Neoplasm Recurrence, Local. Soft Tissue Neoplasms / mortality. Soft Tissue Neoplasms / surgery. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17066433.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Campbell D, Jeffrey RR, Wallis F, Hulks G, Kerr KM: Metastatic pulmonary ameloblastoma. An unusual case. Br J Oral Maxillofac Surg; 2003 Jun;41(3):194-6
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  • [Title] Metastatic pulmonary ameloblastoma. An unusual case.
  • We present a patient who had a large metastatic pulmonary ameloblastoma resected 25 years after removal of an apparently benign primary ameloblastoma of the jaw.
  • It highlights three areas: problems with the histopathological diagnosis of pulmonary metastases using fine needle aspiration; a noted radiological improvement after a 5-year course of oral cyclophosphamide, in keeping with occasional patients who have responded to chemotherapy; and the technical difficulties of resection of a large pulmonary metastasis, particularly when it is adherent to the mediastinum.
  • [MeSH-major] Ameloblastoma / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents, Alkylating / therapeutic use. Biopsy, Needle. Carcinoma, Squamous Cell / pathology. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Humans. Male. Mediastinal Neoplasms / pathology. Middle Aged. Neoplasm Recurrence, Local / pathology. Time Factors

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  • (PMID = 12804548.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 8N3DW7272P / Cyclophosphamide
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12. Sauk JJ, Nikitakis NG, Scheper MA: Are we on the brink of nonsurgical treatment for ameloblastoma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):68-78
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  • [Title] Are we on the brink of nonsurgical treatment for ameloblastoma?
  • OBJECTIVE: Recent identification of altered molecular signaling pathways in neoplasia has begun to elucidate mechanisms of oncogenesis, differentiation, and tumor progression, and to suggest plausible nonsurgical considerations for treatment.
  • Here we review the sonic hedgehog (SHH) and PI3K/Akt/mTOR signaling pathways, their role in ameloblastoma, a locally aggressive odontogenic tumor, and evidence for consideration of therapeutic approaches that target these molecular pathways.
  • STUDY DESIGN: This is a comprehensive review of the literature regarding alterations in signaling mechanisms associated with ameloblastomas.
  • In addition, this review attempts to explore and discuss possible inhibitors to these pathways that may have utility in treating ameloblastoma.
  • RESULTS: The expression of SHH signaling molecules in ameloblastomas at the mRNA and protein levels has intimated that these molecules may play a role in cell proliferation of these tumors.
  • Immunohistochemical analysis has revealed aberrant signaling in the PI3K/Akt/mTOR pathway in ameloblastomas and appears to be a valuable tool for elucidating pathogenesis and aggressiveness, and selecting optimal therapeutics.
  • CONCLUSION: The understanding of altered pathways in ameloblastoma may soon provide nonsurgical options for the treatment of this condition.
  • Thus, tumors that entirely depend on active SHH signaling for survival/growth and maintenance may well be susceptible targets for combined chemotherapy with SHH-specific inhibitors together with PI3K, Akt, or mTOR blocking agents.
  • [MeSH-major] Ameloblastoma / drug therapy. Signal Transduction / drug effects
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Hedgehog Proteins / antagonists & inhibitors. Hedgehog Proteins / physiology. Humans. Intracellular Signaling Peptides and Proteins / antagonists & inhibitors. Intracellular Signaling Peptides and Proteins / physiology. Phosphatidylinositol 3-Kinases / antagonists & inhibitors. Phosphatidylinositol 3-Kinases / physiology. Protein-Serine-Threonine Kinases / antagonists & inhibitors. Protein-Serine-Threonine Kinases / physiology. Proto-Oncogene Proteins c-akt / antagonists & inhibitors. Proto-Oncogene Proteins c-akt / physiology. TOR Serine-Threonine Kinases. Transcription Factors / antagonists & inhibitors. Transcription Factors / physiology

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20418126.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / SHH protein, human; 0 / Transcription Factors; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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13. Nishimori H, Takahashi S, Nagasaki E, Kobayashi T, Yokoyama M, Shinozaki E, Mishima Y, Terui Y, Chin K, Mizunuma N, Ito Y, Inamura K, Hatake K: [An autopsied case of metastatic endocrine carcinoma of the pancreas with primary site difficult to identify]. Gan To Kagaku Ryoho; 2005 May;32(5):671-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 40-year-old man suffering from right cheek swelling was first diagnosed with ameloblastoma or anaplastic poorly-differentiated carcinoma of the head and neck region.
  • He received 2 courses of CDDP/TXT chemotherapy (cisplatin 75 mg/m2, docetaxel 80 mg/m2) and achieved a partial response, but his carcinoma of the pancreas recurred.
  • He also achieved a partial response with 2 courses of CBDCA/TXL regimen (carboplatin AUC=6, paclitaxel 200 mg/m2), but later died from his progressive disease.
  • This case was close to a cancer with an unknown primary (CUP) site, and several favorable sub-sets of CUP have been identified, which are responsive to systemic chemotherapy.
  • Poorly-differentiated neuroendocrine carcinomas like this case are highly sensitive to chemotherapy, and a careful pathological diagnosis may clarify its sensitivity to chemotherapy and the prognosis.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Cisplatin / administration & dosage. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / pathology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Metastasis. Paclitaxel / administration & dosage. Taxoids / administration & dosage

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  • (PMID = 15918570.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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14. Diba R, Saadati HG, Esmaeli B: Outcomes of dacrocystorhinostomy in patients with head and neck tumors. J Clin Oncol; 2004 Jul 15;22(14_suppl):5584

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The tumor diagnoses were as follows: squamous cell carcinoma (SCCA), 18 patients (16 had paranasal-sinus SCCA and 2 had skin SCCA); chondrosarcoma, 3; sinonasal carcinoma, 2; adenoid cystic carcinoma, 2; sinonasal papilloma, 2; esthesioneuroblastoma, 1; hemangiopericytoma,1; ameloblastoma,1; and ostoesarcoma,1.
  • Six patients had had silicone intubation at the time of maxillectomy but later developed epiphora and nasolacrimal duct blockage.
  • Ten patients had radiotherapy and 14 had chemotherapy and radiotherapy before DCR.
  • The mean time between completion of radiotherapy and DCR was 24 months (median, 31.5 months), and the mean time between completion of chemotherapy and DCR was 21.5 months (median, 12.5 months).
  • In 1 of these 4 patients, tumor recurrence in the nasal cavity was the cause; he subsequently underwent a total rhinectomy.
  • None of the patients who had had radiotherapy developed osteoradionecrosis.
  • Two patients had mild wound infections, which resolved after 1 week of systemic antibiotic therapy.

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  • (PMID = 28014063.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Atanasov DT, Indjov SI, Lalabonova HK, Neichev DS: Sarcomas of the mandible. Literature review and case reports. Folia Med (Plovdiv); 2004;46(2):31-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The present study reports three cases (osteogenic sarcoma, fibrosarcoma, chondrosarcoma) with specific clinical and radiographic characteristics, demonstrating the differences between the various types of sarcomas.
  • Special attention is paid to the first clinical signs and symptoms, and to the differential diagnosis with inflammatory conditions (post-extraction alveolitis, chronic odontogenic osteomyelitis), benign tumors (osteoblastoclastoma, ameloblastoma, odontogenic cysts, fibrous dysplasia) and centrally developing jaw carcinomas.
  • Particular emphasis is given to CT imaging and morphological examinations in making an accurate diagnosis and providing adequate treatment.
  • Early diagnosis and precise surgical treatment (total resection or hemiexarticulation, or neck dissection if submandibular or cervical metastases are present) are essential to achieve satisfactory management of these malignant neoplasms.
  • The radiotherapy and chemotherapy administered according to the histologic features of the tumor are also of significance.

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  • (PMID = 15506548.001).
  • [ISSN] 0204-8043
  • [Journal-full-title] Folia medica
  • [ISO-abbreviation] Folia Med (Plovdiv)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Bulgaria
  • [Number-of-references] 21
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16. Van Dam SD, Unni KK, Keller EE: Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience. J Oral Maxillofac Surg; 2010 Dec;68(12):2962-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience.
  • PURPOSE: To provide a comprehensive review of metastasizing (malignant) ameloblastoma, establish a new baseline of valid cases using histologic criteria and minimum documentation, and report 3 cases from the Mayo Clinic files.
  • PATIENTS AND METHODS: Ninety-eight original reports of "metastasizing," "malignant," or "atypical" ameloblastoma were reviewed.
  • The following data were gathered for reports that demonstrated well-differentiated ameloblastoma at the metastatic site: gender, ethnicity, age at time of primary tumor diagnosis, histologic pattern of primary tumor, anatomic sites of primary and metastatic tumors, interval from diagnosis of primary to diagnosis of metastasis, number of recurrences preceding metastasis, treatment responses to radiation and/or chemotherapy, presence of hypercalcemia, and length of survival after metastasis.
  • RESULTS: Twenty-seven valid reports of metastasizing (malignant) ameloblastoma were identified; 81% originated in the mandible, recurring on average 4 times before metastasis.
  • The average time from diagnosis of primary to metastasis was 18 years.
  • Those patients who had succumbed to their disease had an average survival time of 3 years after diagnosis of metastasis.
  • CONCLUSIONS: Metastasis of well-differentiated ameloblastoma occurs more rarely than previously believed.
  • Metastasis to the lungs bilaterally, by the hematogenous route, usually follows multiple failed attempts at primary tumor control.
  • Treatment of metastasizing (malignant) ameloblastoma should include close observation, thoracotomy with wedge resections, or experimental chemotherapeutic combinations.
  • [MeSH-major] Ameloblastoma / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology

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  • [Copyright] Copyright © 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20970910.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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17. Ricard AS, Majoufre-Lefebvre C, Siberchicot F, Laurentjoye M: A multirecurrent ameloblastoma metastatic to the lung. Rev Stomatol Chir Maxillofac; 2010 Apr;111(2):98-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A multirecurrent ameloblastoma metastatic to the lung.
  • INTRODUCTION: The ameloblastoma is a rare tumor of odontogenic epithelial origin.
  • We present a case of a multirecurrent ameloblastoma of the mandible metastatic to the lung.
  • OBSERVATION: We present a case of a mandibular malignant ameloblastoma in a 42-year old man with widespread pulmonary metastases.
  • DISCUSSION: Ameloblastoma metastasis often occurs in the lung.
  • The curative treatment is surgical.
  • The results of palliative chemotherapy and radiotherapy are not always efficient.
  • [MeSH-major] Ameloblastoma / pathology. Ameloblastoma / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology. Mandibular Neoplasms / surgery

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  • (PMID = 20347463.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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18. Zhang L, Zeng D, Huang H, Wang J, Tao Q, Pan C, Xu J, Zhang B, Wang A: Tissue inhibitor of metalloproteinase-2 inhibits ameloblastoma growth in a new mouse xenograft disease model. J Oral Pathol Med; 2010 Jan;39(1):94-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tissue inhibitor of metalloproteinase-2 inhibits ameloblastoma growth in a new mouse xenograft disease model.
  • BACKGROUND: Ameloblastomas are odontogenic neoplasms characterized by local invasiveness.
  • This study was conducted to develop a new animal model of ameloblastoma and to address the role of tissue inhibitor of metalloproteinase-2 (TIMP-2) and matrix metalloproteinase-2 (MMP-2) in the growth and invasiveness of ameloblastomas.
  • METHOD: Donated fresh human ameloblastoma tissue was finely minced, screened, and subcutaneously implanted in three locations on each of 10 BALB/c-nu/nu nude mice.
  • RESULTS: The ameloblastoma xenografts were established with high frequency and contained a variety of typical features, validating this new model system.
  • CONCLUSIONS: We successfully established a new experimental model of ameloblastoma consisting of subcutaneous human xenografts in nude mice.
  • In addition, we demonstrated the successful introduction of the TIMP-2 gene in tumor xenograft cells in vivo, resulting in xenograft growth inhibition.
  • [MeSH-major] Ameloblastoma / drug therapy. Neoplasm Transplantation. Soft Tissue Neoplasms / drug therapy. Tissue Inhibitor of Metalloproteinase-2 / therapeutic use. Transplantation, Heterologous
  • [MeSH-minor] Adult. Animals. Blotting, Western. Disease Models, Animal. Female. Genetic Vectors / therapeutic use. Humans. Matrix Metalloproteinase 2. Matrix Metalloproteinase Inhibitors. Mice. Mice, Inbred BALB C. Mice, Nude. Neoplasm Invasiveness. Plasmids / therapeutic use. Reverse Transcriptase Polymerase Chain Reaction. Subcutaneous Tissue / surgery. Transfection. Tumor Cells, Cultured

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  • (PMID = 19895658.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Matrix Metalloproteinase Inhibitors; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.24 / Mmp2 protein, mouse
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19. Diba R, Saadati H, Esmaeli B: Outcomes of dacryocystorhinostomy in patients with head and neck tumors. Head Neck; 2005 Jan;27(1):72-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The tumor diagnoses were squamous cell carcinoma (n = 18), chondrosarcoma (n = 3), sinonasal carcinoma (n = 2), adenoid cystic carcinoma (n = 2), sinonasal papilloma (n = 2), esthesioneuroblastoma (n = 1); hemangiopericytoma (n = 1); ameloblastoma (n = 1), and osteosarcoma (n = 1).
  • Twenty-eight patients had a maxillectomy or other sinus surgeries, 10 had radiotherapy, and 14 had chemotherapy and radiotherapy before DCR.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Ethmoid Bone / surgery. Female. Humans. Male. Maxilla / surgery. Middle Aged. Paranasal Sinuses / surgery. Radiotherapy, Adjuvant. Recurrence. Retrospective Studies. Sphenoid Bone / surgery. Treatment Outcome

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  • [Copyright] Copyright 2004 Wiley Periodicals, Inc.
  • (PMID = 15565560.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Kelly JM, Belding BA, Schaefer AK: Acanthomatous ameloblastoma in dogs treated with intralesional bleomycin. Vet Comp Oncol; 2010 Jun;8(2):81-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acanthomatous ameloblastoma in dogs treated with intralesional bleomycin.
  • Acanthomatous ameloblastoma (AA) is a benign gingival tumour that often invades bone.
  • This retrospective study evaluated the efficacy of intralesional (IL) bleomycin as a treatment for AA.
  • One to sixteen treatments were administered (median, 5).
  • Local recurrence was not observed during the study period, with a median follow-up time of 842 days.
  • Adverse effects were limited to wound formation with bone exposure (n = 4), mild tissue reactions (n = 3), local swelling (n = 2) and local infection (n = 1).
  • The conclusions of this study show IL bleomycin is an effective treatment for canines with AA.
  • [MeSH-major] Ameloblastoma / veterinary. Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Dog Diseases / drug therapy. Gingival Neoplasms / veterinary
  • [MeSH-minor] Animals. Dogs. Female. Injections, Intralesional / veterinary. Male. Retrospective Studies. Treatment Outcome

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  • (PMID = 20579320.001).
  • [ISSN] 1476-5829
  • [Journal-full-title] Veterinary and comparative oncology
  • [ISO-abbreviation] Vet Comp Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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21. Dudek AZ, Murthaiah PK, Franklin M, Truskinovsky AM: Metastatic adamantinoma responds to treatment with receptor tyrosine kinase inhibitor. Acta Oncol; 2010;49(1):101-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic adamantinoma responds to treatment with receptor tyrosine kinase inhibitor.
  • [MeSH-major] Adamantinoma / drug therapy. Adamantinoma / pathology. Antineoplastic Agents / therapeutic use. Indoles / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Pyrroles / therapeutic use
  • [MeSH-minor] Accidents, Traffic. Appendicitis / complications. Enzyme Inhibitors / therapeutic use. Foot / pathology. Fractures, Bone / complications. Humans. Immunohistochemistry. Male. Middle Aged. Psoriasis / complications. Receptor Protein-Tyrosine Kinases / antagonists & inhibitors. Smoking. Tomography, X-Ray Computed. Vitamin B 12 Deficiency / complications

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  • (PMID = 19412810.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Enzyme Inhibitors; 0 / Indoles; 0 / Pyrroles; 0 / sunitinib; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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