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1. Kinjo S, Sakurai S, Hirato J, Sunose Y: Embryonal sarcoma of the liver with chondroid differentiation. World J Gastrointest Oncol; 2010 May 15;2(5):247-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Embryonal sarcoma of the liver with chondroid differentiation.
  • Computed tomography revealed that the tumor, measuring 14.5 cm × 10.4 cm, occupied the anterior and medial segments of the liver and consisted of multicystic and solid lesions.
  • The preoperative diagnosis was a hepatic cystadenocarcinoma.
  • The final diagnosis was embryonal sarcoma of the liver (ESL).
  • At 6 mo follow-up, the patient is alive with the disease and undergoing chemotherapy.

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  • (PMID = 21160625.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999185
  • [Keywords] NOTNLM ; Adult / Chondroid differentiation / Immunohistochemistry / Liver tumor / Undifferentiated sarcoma
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2. Lee JA, Kim TW, Min JH, Byon SJ, Jang SH, Choi SY, Kim HJ: [A case of undifferentiated (embryonal) liver sarcoma mimicking klatskin tumor in an adult]. Korean J Gastroenterol; 2010 Feb;55(2):144-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of undifferentiated (embryonal) liver sarcoma mimicking klatskin tumor in an adult].
  • Undifferentiated sarcoma is an uncommon primary malignant tumor of the liver typically occurring in older children.
  • It is also referred to as malignant mesenchymoma, fibromyxosarcoma, or mesenchymal sarcoma.
  • We experienced a case of undifferentiated sarcoma in 72-year-old male.
  • Contrast enhanced liver CT scan revealed a 3.4 cm heterogeneously enhancing, ill-defined, and low attenuated mass in the left liver and subtle intrahepatic duct dilatation.
  • We did ultrasonography guided liver biopsy.
  • These tumor cells were positive for vimentin only, and the tumor was consistent with undifferentiated sarcoma of the liver.
  • [MeSH-major] Liver Neoplasms / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Aged. Bile Ducts, Intrahepatic / pathology. Diagnosis, Differential. Dilatation, Pathologic. Humans. Klatskin Tumor / diagnosis. Male. Positron-Emission Tomography. Tomography, X-Ray Computed. Tuberculosis / diagnostic imaging. Tuberculosis / drug therapy. Ultrasonography. Vimentin / metabolism

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  • (PMID = 20168062.001).
  • [ISSN] 2233-6869
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Vimentin
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3. Lenze F, Birkfellner T, Lenz P, Hussein K, Länger F, Kreipe H, Domschke W: Undifferentiated embryonal sarcoma of the liver in adults. Cancer; 2008 May 15;112(10):2274-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Undifferentiated embryonal sarcoma of the liver in adults.
  • BACKGROUND: Undifferentiated embryonal sarcoma of the liver (UESL), a rare tumor that predominantly affects children, generally has been considered an aggressive neoplasm with an unfavorable prognosis.
  • More recent reports have indicated that modern multimodal treatment and supportive care improve the survival of children with UESL.
  • Data regarding the treatment and survival of adults have not been reviewed comprehensively, and only a few adult patients with UESL have been reported in the literature.
  • METHODS: The authors analyzed demographics, treatment, and actuarial survival of all reported cases of UESL in patients aged >or=15 years (n = 67 patients).
  • Patients who underwent complete tumor resection followed by adjuvant chemotherapy survived over a median follow-up of 28.5 months and had significantly better survival compared with patients who underwent surgical treatment alone.
  • CONCLUSIONS: To the authors' knowledge, this is the first report to demonstrate a significant effect on survival for adjuvant chemotherapy after complete surgical resection of UESL in adults.
  • The role of neoadjuvant chemotherapy was not evaluated in this study.
  • In the case study presented herein, combined therapy with surgery and chemotherapy led to a complete, sustained remission that has lasted for >6 years to date.
  • [MeSH-major] Liver Neoplasms / mortality. Liver Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / mortality. Neoplasms, Germ Cell and Embryonal / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Immunoenzyme Techniques. Male. Middle Aged. Survival Rate. Tomography, X-Ray Computed

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18361435.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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4. Sakellaridis T, Panagiotou I, Georgantas T, Micros G, Rontogianni D, Antiochos C: Undifferentiated embryonal sarcoma of the liver mimicking acute appendicitis. Case report and review of the literature. World J Surg Oncol; 2006;4:9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Undifferentiated embryonal sarcoma of the liver mimicking acute appendicitis. Case report and review of the literature.
  • BACKGROUND: Undifferentiated embryonal sarcoma (UES) of liver is a rare malignant neoplasm, which affects mostly the pediatric population accounting for 13% of pediatric hepatic malignancies, a few cases has been reported in adults.
  • CASE PRESENTATION: We report a case of undifferentiated embryonal sarcoma of the liver in a 20-year-old Caucasian male.
  • The patient was referred to us for further investigation after a laparotomy in a district hospital for spontaneous abdominal hemorrhage, which was due to a liver mass.
  • After a through evaluation with computed tomography scan and magnetic resonance imaging of the liver and taking into consideration the previous history of the patient, it was decided to surgically explore the patient.
  • Patient developed disseminated intravascular coagulation one day after the surgery and died the next day.
  • The prognosis is poor but recent evidence has shown that long-term survival is possible after complete surgical resection with or without postoperative chemotherapy.

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  • [Cites] Eur J Gastroenterol Hepatol. 2000 Nov;12(11):1247-51 [11111784.001]
  • [Cites] Chirurg. 2000 Jan;71(1):101-5 [10663012.001]
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  • (PMID = 16504010.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1403776
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5. Bisogno G, Pilz T, Perilongo G, Ferrari A, Harms D, Ninfo V, Treuner J, Carli M: Undifferentiated sarcoma of the liver in childhood: a curable disease. Cancer; 2002 Jan 1;94(1):252-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Undifferentiated sarcoma of the liver in childhood: a curable disease.
  • BACKGROUND: Undifferentiated (embryonal) sarcoma of the liver (UESL) is a rare childhood hepatic tumor, and it is generally considered an aggressive neoplasm with an unfavorable prognosis.
  • METHODS: The Soft Tissue Sarcoma Italian and German Cooperative Groups enrolled 17 children with UESL in studies conducted between 1979 and 1995.
  • They were treated using the same multimodal approach as for patients with sarcomas including conservative surgery at diagnosis, multiagent chemotherapy, and second-look operation in cases of residual disease.
  • Eight underwent complete tumor resection either at diagnosis or after preoperative chemotherapy, and all are currently alive.
  • After initial chemotherapy tumor reduction was evident in six of nine evaluable cases.
  • Modern multimodal treatment and supportive therapy have improved survival.
  • [MeSH-major] Liver Neoplasms / therapy. Sarcoma / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Infant. Male. Neoplasm Staging. Remission Induction

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  • [Copyright] Copyright 2002 American Cancer Society.
  • (PMID = 11815984.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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6. Kim KT, Han SY, Park EH, Jang JS, Roh MH, Lee SW, Jeong JS: [A case of the treatment in an adult with hepatic undifferentiated (embryonal) sarcoma]. Korean J Hepatol; 2007 Mar;13(1):96-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of the treatment in an adult with hepatic undifferentiated (embryonal) sarcoma].
  • Undifferentiated embryonal sarcoma is a rare primary malignant neoplasm of the liver.
  • Undifferentiated sarcoma of the liver in adult is an uncommon hepatic tumor of mesenchymal origin, generally considered an aggressive neoplasm with an unfavorable prognosis.
  • We present a case of undifferentiated sarcoma in a 61-year-old woman.
  • US guided liver biopsy was done and pathological findings of the liver specimen revealed that isolated or grouped round pleomorphic cells and spindle to stellate cells were present.
  • She was diagnosed as having undifferentiated sarcoma of the liver.
  • She received seven courses of VAIA chemotherapy by CWS protocols.
  • Chemotherapy was efficacious and the size of the tumor decreased considerably after the treatment.
  • [MeSH-major] Liver Neoplasms / diagnosis. Liver Neoplasms / drug therapy. Sarcoma / diagnosis. Sarcoma / drug therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dactinomycin / therapeutic use. Doxorubicin / therapeutic use. Female. Humans. Ifosfamide / therapeutic use. Middle Aged. Tomography, X-Ray Computed. Vincristine / therapeutic use

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  • (PMID = 17380080.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide; VAIA protocol
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7. Iqbal K, Xian ZM, Yuan C: Undifferentiated liver sarcoma -- rare entity: a case report and review of the literature. J Med Case Rep; 2008;2:20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Undifferentiated liver sarcoma -- rare entity: a case report and review of the literature.
  • INTRODUCTION: Undifferentiated Liver Sarcoma, also known as Undifferentiated Embryonal Sarcoma of the Liver, is a rare, highly malignant neoplasm which affects mostly the pediatric population, although a few cases have been reported in adults.
  • CASE PRESENTATION: We report a case of undifferentiated liver sarcoma in a 14-year-old Chinese boy who presented with non-specific right hypochondriac pain.
  • Exploratory laparotomy with tumor resection was performed, followed by adjuvant chemotherapy.
  • CONCLUSION: Undifferentiated Liver Sarcoma is a rare, highly malignant hepatic neoplasm affecting almost exclusively the pediatric population.
  • The prognosis is poor but recent evidence shows that long-term survival is possible after complete surgical resection and postoperative chemotherapy.

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  • [Cites] Chirurg. 2000 Jan;71(1):101-5 [10663012.001]
  • [Cites] J Pediatr Surg. 2002 Oct;37(10):1419-23 [12378446.001]
  • [Cites] Eur J Surg Oncol. 2004 May;30(4):421-7 [15063896.001]
  • [Cites] Cancer. 1992 Jan 1;69(1):39-44 [1727674.001]
  • [Cites] Radiology. 1997 Jun;203(3):779-83 [9169704.001]
  • [Cites] Cancer. 1978 Jul;42(1):336-48 [208754.001]
  • [Cites] Abdom Imaging. 1993;18(2):176-9 [8439759.001]
  • [Cites] Br J Radiol. 1997 Mar;70:314-6 [9166061.001]
  • [Cites] Cancer. 1992 Jan 1;69(1):52-9 [1727675.001]
  • (PMID = 18218141.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2253550
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8. McCarthy FP, Harris M, Kornman L: Management of undifferentiated embryonal sarcoma of the liver in pregnancy. Obstet Gynecol; 2007 Feb;109(2 Pt2):558-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of undifferentiated embryonal sarcoma of the liver in pregnancy.
  • BACKGROUND: Undifferentiated embryonal sarcoma of the liver is a rare mesenchymal neoplasm with a poor prognosis.
  • Our patient was a woman whose pregnancy was complicated by the recurrence of metastatic undifferentiated embryonal sarcoma of the liver.
  • CASE: In the medical literature only two other women have been described with metastatic undifferentiated embryonal sarcoma of the liver in pregnancy.
  • This is the first reported case of undifferentiated embryonal sarcoma of the liver recurring in and requiring treatment during pregnancy.
  • The patient gave birth to a healthy son before requiring further palliative chemotherapy.
  • CONCLUSION: This case highlights the fact that cancer not infrequently complicates pregnancy and can require treatment, in this case with radio frequency ablation.
  • [MeSH-major] Liver Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Prenatal Diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Catheter Ablation. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Infant, Newborn. Magnetic Resonance Imaging. Male. Pregnancy


9. Wei ZG, Tang LF, Chen ZM, Tang HF, Li MJ: Childhood undifferentiated embryonal liver sarcoma: clinical features and immunohistochemistry analysis. J Pediatr Surg; 2008 Oct;43(10):1912-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Childhood undifferentiated embryonal liver sarcoma: clinical features and immunohistochemistry analysis.
  • PURPOSE: The aim of the study was to report on 3 cases of childhood undifferentiated embryonal liver sarcoma (UELS) and to highlight the clinical features, laboratory findings, diagnosis, and management of this rare disease.
  • METHODS: The patients' age, sex, clinical features, laboratory findings, pathologic results, and therapy were reviewed.
  • Histopathologic evaluation of the mass confirmed the diagnosis of UELS.
  • Surgery with chemotherapy was performed in 2 cases.
  • CONCLUSION: The diagnosis of UELS depends mainly on the pathologic findings.
  • Undifferentiated embryonal liver sarcoma should be included in the differential diagnosis of mass in the liver, especially with well-defined heterogeneous imaging findings and normal AFP.
  • Diagnosis and management should be made early as UELS is a potentially treatable tumor.
  • [MeSH-major] Biomarkers, Tumor / analysis. Liver Neoplasms / pathology. Neoplasm Proteins / analysis. Neoplasms, Germ Cell and Embryonal / pathology. Sarcoma / pathology
  • [MeSH-minor] Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Cisplatin / administration & dosage. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Desmin / analysis. Dexamethasone / administration & dosage. Doxorubicin / administration & dosage. Fatal Outcome. Female. Hepatectomy. Humans. Ifosfamide / administration & dosage. Male. Neoadjuvant Therapy. Remission Induction. Vimentin / analysis. Vinblastine / administration & dosage

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  • (PMID = 18926232.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / Desmin; 0 / Neoplasm Proteins; 0 / Vimentin; 5V9KLZ54CY / Vinblastine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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10. Kim DY, Kim KH, Jung SE, Lee SC, Park KW, Kim WK: Undifferentiated (embryonal) sarcoma of the liver: combination treatment by surgery and chemotherapy. J Pediatr Surg; 2002 Oct;37(10):1419-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Undifferentiated (embryonal) sarcoma of the liver: combination treatment by surgery and chemotherapy.
  • BACKGROUND/PURPOSE: Undifferentiated (embryonal) sarcoma of the liver (USL) is a rare malignancy found in older children, and the most appropriate treatment strategy has been controversial.
  • The authors report the tumor's clinical characteristics and the results of management in 6 children and recommend the best treatment plans based on these findings.
  • RESULTS: The mean age at diagnosis of USL was 10.3 years (range, 7 to 13 years).
  • Three children underwent primary complete resection without preoperative chemotherapy.
  • However, complete resection was possible at second-look operation after chemotherapy.
  • Two children underwent complete resection after chemotherapy.
  • Preoperative chemotherapy allowed successful resection of 3 USL, which were initially considered unresectable.
  • Chemotherapy according to the the Third Intergroup Rhabdomyosarcoma Study (IRS III) was administered to all except one child who refused further postoperative chemotherapy after having had severe complications during the first cycle of chemotherapy.
  • One child with partial resection died of sepsis at 22 months after diagnosis during postoperative chemotherapy after complete surgical removal of the tumor.
  • Five children are alive without recurrence at 40, 45, 48, 60, and 122 months, respectively, after diagnosis.
  • CONCLUSION: The combined therapy of surgery and chemotherapy in USL can improve the prognosis.
  • [MeSH-major] Liver Neoplasms / drug therapy. Liver Neoplasms / surgery. Mesenchymoma / drug therapy. Mesenchymoma / surgery
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy. Female. Hepatectomy. Humans. Male. Prognosis. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright 2002, Elsevier Science (USA). All rights reserved.
  • (PMID = 12378446.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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11. Nicol K, Savell V, Moore J, Teot L, Spunt SL, Qualman S, Children's Oncology Group, Soft Tissue Sarcoma Committee: Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: a Children's Oncology Group study. Pediatr Dev Pathol; 2007 Mar-Apr;10(2):89-97
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: a Children's Oncology Group study.
  • Morphologically, the distinction between undifferentiated embryonal sarcoma of the liver (UESL) and biliary tract rhabdomyosarcoma (RMS) can be uncertain because of some shared pathologic similarities.
  • Patients with UESL have been consistently but erroneously enrolled in Children's Oncology Group (COG) treatment protocols because UESL was equated with RMS, despite the differing primary treatment modalities of these entities.
  • Establishing the correct diagnosis of these distinct clinical and pathologic entities is important, as surgery alone may be curative in UESL, whereas initial chemotherapy is often recommended for the treatment of biliary tract RMS.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Biomarkers, Tumor / analysis. Liver Neoplasms / diagnosis. Rhabdomyosarcoma / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Child. Child, Preschool. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. MyoD Protein / metabolism. Myogenin / metabolism. Neoplasm Proteins / metabolism. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome


12. Anavi BL, Moumdjiev IN, Stoyanova AA, Sapunarova KG, Tashev PV, Dureva-Popova MK: A case of undifferentiated (embryonal) sarcoma of the liver: fine needle aspiration cytology diagnosis by one cell type. Folia Med (Plovdiv); 2001;43(3):53-8
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  • [Title] A case of undifferentiated (embryonal) sarcoma of the liver: fine needle aspiration cytology diagnosis by one cell type.
  • We present the first case in Bulgaria of cytologically verified undifferentiated (embryonal) sarcoma of the liver.
  • A large formation was found in the right liver lobe on ultrasound examination, which was polycystic on CT scan.
  • In the scanty specimen obtained by fine-needle aspiration biopsy under ultrasound control a characteristic prevalence of polygonal cells within mesenchyme tissue was found.
  • The cells are pathognomonic of undifferentiated (embryonal) sarcoma of the liver.
  • After preoperative chemotherapy with ifosfamide, vincristine and actinomycin D (CEVAIE, CWS--96) resection of the tumor including IV, V, VI and VII liver segments was performed.
  • The cytological diagnosis was histologically verified.
  • The patient had a mechanical subileus episode after the 6th course of chemotherapy.
  • The case indicates that the unique cell appearance in embryonal sarcoma of the liver provides a correct diagnosis even in a scanty specimen.
  • [MeSH-major] Liver Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Sarcoma / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biopsy, Needle. Child. Combined Modality Therapy. Female. Humans

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  • (PMID = 11930835.001).
  • [ISSN] 0204-8043
  • [Journal-full-title] Folia medica
  • [ISO-abbreviation] Folia Med (Plovdiv)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bulgaria
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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13. Jiménez Fuertes M, López Andújar R, de Juan Burgueño M, Moya Herráiz A, Sanjuán Rodríguez F, Montalvá Orón E, Pareja Ibars E, Mir Pallardó J: [Hepatic undifferentiated (embryonal) sarcoma in an adult: a case report and literature review]. Gastroenterol Hepatol; 2008 Jan;31(1):12-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hepatic undifferentiated (embryonal) sarcoma in an adult: a case report and literature review].
  • [Transliterated title] Sarcoma indiferenciado (embrionario) de hígado del adulto: informe de un caso y revisión de la literatura médica.
  • Undifferentiated (embryonal) sarcoma of the liver (USL) is a rare malignant hepatic tumor in adults.
  • We report the case of a 40-year-old man with USL who was successfully treated with surgical resection and chemotherapy using ifosfamide and adriamycin.
  • Although the prognosis of the disease remains generally poor, long term survival has been achieved in patients with a combination of surgery and chemotherapy.
  • [MeSH-major] Liver Neoplasms / diagnosis. Sarcoma / diagnosis

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  • (PMID = 18218274.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 44
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14. Küpeli S, Yalçin B, Cil BE, Akçören Z, Büyükpamukçu M: Undifferentiated embryonal sarcoma of the liver in a child complicated by haemorrhage. Pediatr Radiol; 2008 Nov;38(11):1259-61
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  • [Title] Undifferentiated embryonal sarcoma of the liver in a child complicated by haemorrhage.
  • Undifferentiated embryonal sarcoma (UES) of the liver is a rare malignant neoplasm that mostly affects children younger than 15 years of age.
  • The tumour was managed by embolization of the right hepatic artery and treated successfully with chemotherapy and surgical resection.
  • Prophylactic embolization of the feeding artery should be undertaken before a biopsy procedure if there is the possibility of tumour rupture, in the presence of signs of intratumoral or peritumoral bleeding, or in the presence of a vascular liver mass.
  • [MeSH-major] Hemorrhage / etiology. Liver Neoplasms / complications. Neoplasms, Germ Cell and Embryonal / complications
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Combined Modality Therapy. Diagnosis, Differential. Embolization, Therapeutic / methods. Humans. Male. Tomography, X-Ray Computed

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  • [Cites] J Pediatr Surg. 2002 Oct;37(10):1419-23 [12378446.001]
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  • (PMID = 18688607.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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15. Tokunaga Y, Ryo J, Hoppou T, Kitaoka A, Tokuka A, Osumi K, Tanaka T: Hepatic undifferentiated (embryonal) sarcoma in an adult: a case report and review of the literature. Eur J Gastroenterol Hepatol; 2000 Nov;12(11):1247-51
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  • [Title] Hepatic undifferentiated (embryonal) sarcoma in an adult: a case report and review of the literature.
  • Undifferentiated (embryonal) sarcoma of the liver (USL) is a rare malignant tumour with a poor prognosis.
  • The absence of specific symptoms, the rapid tumour growth, the normality of the common tumour markers, and the consequential delay in the diagnosis often result in significant enlargement of the tumour.
  • We report here a 27-year-old male with USL who has been treated successfully with surgical resection and adjuvant chemotherapy using ifosfamide, adriamycin and cisplatin.
  • Although the prognosis of the disease remains generally poor, long-term survival has been achieved recently in patients with a combination of surgery and multi-agent chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols. Liver Neoplasms / drug therapy. Liver Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Germ Cell and Embryonal / surgery
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Cisplatin. Doxorubicin. Hepatectomy. Humans. Ifosfamide. Male

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  • (PMID = 11111784.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; IAP protocol
  • [Number-of-references] 37
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16. Akerboom-Straberger BM, Lotgering FK: Embryonal sarcoma of the liver in pregnancy, associated with HELLP syndrome. Am J Obstet Gynecol; 2004 Feb;190(2):556-7
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  • [Title] Embryonal sarcoma of the liver in pregnancy, associated with HELLP syndrome.
  • After cesarean section, a 30-year-old patient with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count in association with preeclampsia) had fever, jaundice, loss of ascites, and a cardiac murmur.
  • Magnetic resonance imaging showed a tumor extending from the left lobe of the liver into the inferior vena cava, right atrium, and ventricle.
  • The biopsy specimen revealed an embryonal sarcoma of the liver.
  • On the second day of chemotherapy, the patient died of intra-abdominal hemorrhage from the tumor.
  • [MeSH-major] Carcinoma, Embryonal / complications. HELLP Syndrome / complications. Liver Neoplasms / complications. Pregnancy Complications, Neoplastic


17. Baron PW, Majlessipour F, Bedros AA, Zuppan CW, Ben-Youssef R, Yanni G, Ojogho ON, Concepcion W: Undifferentiated embryonal sarcoma of the liver successfully treated with chemotherapy and liver resection. J Gastrointest Surg; 2007 Jan;11(1):73-5
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  • [Title] Undifferentiated embryonal sarcoma of the liver successfully treated with chemotherapy and liver resection.
  • Undifferentiated embryonal sarcoma is the third most common malignant tumor of the liver in children, accounting for 13% of hepatic malignancies in this age group.
  • It has been considered an aggressive neoplasm with very poor prognosis until the late 1980s, when long-term survivors were reported after multiagent chemotherapy followed by resection.
  • We, herein, report two pediatric cases of undifferentiated embryonal sarcoma treated successfully with surgical resection after neoadjuvant chemotherapy based on therapy used in childhood soft tissue sarcomas and in childhood hepatic malignancies.
  • The first patient also had a concurrent cerebellar tumor (pilocytic astrocytoma), for which he first underwent craniotomy and resection, delaying the liver tumor resection by 10 weeks.
  • They are alive and tumor free at 48 months (case no. 1) and 18 months (case no. 2) following neoadjuvant chemotherapy and liver resection.
  • [MeSH-major] Liver Neoplasms / drug therapy. Liver Neoplasms / surgery. Sarcoma / drug therapy. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy. Hepatectomy. Humans. Male. Neoadjuvant Therapy

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  • [Cites] Surg Today. 1992;22(5):451-5 [1421867.001]
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  • (PMID = 17390190.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. Uchiyama M, Iwafuchi M, Yagi M, Iinuma Y, Kanada S, Yamazaki S, Ohtaki M, Shirai Y: Treatment of ruptured undifferentiated sarcoma of the liver in children: a report of two cases and review of the literature. J Hepatobiliary Pancreat Surg; 2001;8(1):87-91
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  • [Title] Treatment of ruptured undifferentiated sarcoma of the liver in children: a report of two cases and review of the literature.
  • Undifferentiated (embryonal) sarcoma of the liver (USL) is a highly malignant tumor of early life.
  • Treatment choices for USL, especially with intraperitoneal rupture, are uncertain.
  • More aggressive chemotherapy has been associated with this change.
  • Of 8 patients with tumor rupture whose details have been reported (including the 2 present patients) after resection of the tumor, 4 died, 1 was alive with disease, and 3 were free of disease at 8, 49, and 58 months, respectively, after diagnosis.
  • Ruptured USL should be treated with combination chemotherapy including CDDP and ADR, as well as with curative resection.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / drug therapy. Liver Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Germ Cell and Embryonal / surgery

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  • (PMID = 11294295.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 26
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19. Chowdhary SK, Trehan A, Das A, Marwaha RK, Rao KL: Undifferentiated embryonal sarcoma in children: beware of the solitary liver cyst. J Pediatr Surg; 2004 Jan;39(1):E9-12
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  • [Title] Undifferentiated embryonal sarcoma in children: beware of the solitary liver cyst.
  • Undifferentiated embryonal sarcoma (UES) of liver is a rare form of liver tumor in children.
  • It may have an atypical presentation leading to delay in diagnosis.
  • Preoperative chemotherapy was successful in shrinking the tumors in 2 children to allow anatomic liver resection with tumor-free margin.
  • Both remain free of recurrence 2 years after completing treatment.
  • [MeSH-major] Cysts / diagnosis. Liver Diseases / diagnosis. Liver Neoplasms / diagnosis. Sarcoma / diagnosis
  • [MeSH-minor] Abdominal Pain / etiology. Child. Child, Preschool. Combined Modality Therapy. Diagnosis, Differential. Female. Fever / etiology. Humans. Male

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  • (PMID = 14694398.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Charfi S, Ayadi L, Toumi N, Frikha F, Daoud E, Makni S, Frikha M, Beyrouti MI, Sellami-Boudawara T: Cystic undifferentiated sarcoma of liver in children: a pitfall diagnosis in endemic hydatidosis areas. J Pediatr Surg; 2008 Jun;43(6):E1-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic undifferentiated sarcoma of liver in children: a pitfall diagnosis in endemic hydatidosis areas.
  • Undifferentiated (embryonal) sarcoma (UES) of the liver is a very rare pediatric neoplasm with an aggressive behavior.
  • Multimodal treatment including complete surgical resection and chemotherapy has improved survival.
  • The diagnosis of hydatid cyst was initially presumed.
  • A complete tumor resection after 3 cycles of chemotherapy was performed.
  • Adjuvant chemotherapy was instituted.
  • Differential diagnosis with hydatid cyst may be problematic in endemic hydatidosis areas.
  • [MeSH-major] Echinococcosis, Hepatic / pathology. Liver Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Sarcoma / pathology
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Adolescent. Biopsy, Needle. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Endemic Diseases. Endosonography / methods. Female. Follow-Up Studies. Hepatectomy / methods. Humans. Immunohistochemistry. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. Tunisia

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  • (PMID = 18558156.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Almogy G, Lieberman S, Gips M, Pappo O, Edden Y, Jurim O, Simon Slasky B, Uzieli B, Eid A: Clinical outcomes of surgical resections for primary liver sarcoma in adults: results from a single centre. Eur J Surg Oncol; 2004 May;30(4):421-7
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  • [Title] Clinical outcomes of surgical resections for primary liver sarcoma in adults: results from a single centre.
  • BACKGROUND: Primary hepatic sarcoma is a rare tumour with a poor prognosis.
  • METHODS: From 1997 to 2002 eight patients had liver resection for primary sarcoma of the liver at our institution.
  • The clinical characteristics, imaging findings, surgical procedures, adjuvant therapy and outcome were retrospectively reviewed.
  • There were two patients each with angiosarcoma (AS), leiomyosarcoma (LMS), and undifferentiated embryonal sarcoma (UES), one patient with epithelioid hemangioendothelioma (EHE) and one patient with malignant peripheral nerve sheath sarcoma (PNSS).
  • Preoperative diagnosis of a primary liver sarcoma was made in 7/8 cases, either by fine needle aspiration (n = 5) or angiography (n = 2).
  • Two patients developed complications and there was one death.
  • Systemic chemotherapy led to tumour regression in both patients with UES which enabled a second hepatic resection.
  • CONCLUSIONS: The majority of patients with primary liver sarcoma present with right upper quadrant pain, fever and a liver mass.
  • Differentiating the rare primary liver sarcoma from the much more common hepatocellular carcinoma (HCC) may aid in planning therapy.
  • Liver resection combined with adjuvant chemotherapy are the mainstays of treatment for UES in the adult.
  • [MeSH-major] Liver Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Diagnosis, Differential. Female. Hepatectomy / methods. Humans. Length of Stay. Liver Function Tests. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15063896.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. Yu DC, Tandon R, Bohlke AK, Steiner RB, Haque S, Florman SS: Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. J La State Med Soc; 2009 Jan-Feb;161(1):41-4
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  • [Title] Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature.
  • BACKGROUND: Undifferentiated (embryonal) sarcoma (UES) of the liver is a malignant hepatic neoplasm accounting for 7% of pediatric hepatic tumors.
  • Current use of multimodal therapy, including chemotherapy and surgery, has greatly improved survival.
  • Tumor rupture is uncommon and, prior to the adjuvant use of sarcoma based chemotherapy regimens, was thought to be poor prognostic sign.
  • CASE PRESENTATION AND DISCUSSION: A 10-year-old girl presented with acute worsening of abdominal pain while being worked up for liver mass.
  • She subsequently received adjuvant chemotherapy and radiation.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / surgery. Sarcoma / surgery

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  • (PMID = 19278169.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Kelly MJ, Martin L, Alonso M, Altura RA: Liver transplant for relapsed undifferentiated embryonal sarcoma in a young child. J Pediatr Surg; 2009 Dec;44(12):e1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver transplant for relapsed undifferentiated embryonal sarcoma in a young child.
  • Undifferentiated embryonal sarcoma of the liver is a rare hepatic malignancy of childhood with a historically poor prognosis.
  • Recent improvements in outcomes have been reported in small numbers of cases with the use of combination therapy involving aggressive surgical resection and chemotherapy.
  • Here we report a case of undifferentiated embryonal sarcoma of the liver that recurred along surgical hepatic vein margins in a 9-year-old boy who subsequently underwent orthotopic liver transplantation from a cadaveric donor.
  • [MeSH-major] Liver Neoplasms / surgery. Liver Transplantation / methods. Neoplasms, Germ Cell and Embryonal / surgery. Sarcoma / surgery
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy. Humans. Male. Recurrence. Tomography, X-Ray Computed. Treatment Outcome


24. Shinoda H, Yoshida A, Teruya-Feldstein J: Malignant histiocytoses/disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor. Appl Immunohistochem Mol Morphol; 2009 Jul;17(4):338-44
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  • [Title] Malignant histiocytoses/disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor.
  • We describe a case of a 24-year-old man with a large anterior mediastinal mass showing a nonseminomatous germ cell tumor then subsequently developed hemophagocytic syndrome involving the bone marrow and liver.
  • During the course of chemotherapy, he developed profound thrombocytopenia, eccymoses, and bleeding.
  • He had moderate splenomegaly and splenectomy was performed to restore adequate hematologic reserve to permit further chemotherapy.
  • The patient was refractory to therapy and ultimately died 5 months after diagnosis.

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  • (PMID = 18987551.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / S100 Proteins
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25. Corapçioglu F, Sarper N, Demir H, Güvenç BH, Sözübir S, Akansel G, Berk FS: A child with undifferentiated sarcoma of the liver complicated with bronchobiliary fistula and detected by hepatobiliary scintigraphy. Pediatr Hematol Oncol; 2004 Jul-Aug;21(5):427-33
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  • [Title] A child with undifferentiated sarcoma of the liver complicated with bronchobiliary fistula and detected by hepatobiliary scintigraphy.
  • Undifferentiated (embryonal) sarcoma of the liver (USL) is a rare malignant mesenchymal tumor principally affecting patients of pediatric age.
  • Bronchobiliary fistula is a very rare complication in patients with liver tumor.
  • To the authors' knowledge, this is the first report of a bronchobiliary fistula resulting from tumor invasion in a child with liver sarcoma.
  • A 12-year-old boy was diagnosed to have USL of the right liver lobe, invading the diaphragm.
  • An extended right hepatectomy and total resection of the mass was performed, leaving patchy tumoral invasion of the anterior diaphragmatic surface followed by combined chemotherapy regimen.
  • Hepatobiliary scintigraphy is the useful diagnostic procedure to define bronchobiliary fistula in children with liver tumor and clinical suspicion of bronchobiliary fistula.
  • [MeSH-major] Biliary Tract Diseases / complications. Biliary Tract Diseases / radionuclide imaging. Bronchial Fistula / complications. Bronchial Fistula / radionuclide imaging. Liver Neoplasms / complications. Sarcoma / complications. Technetium Tc 99m Disofenin

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  • (PMID = 15205086.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] QTJ2VIW97T / Technetium Tc 99m Disofenin
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26. Chuang WY, Lin JN, Hung IJ, Hsueh C: Undifferentiated sarcoma of the liver. Chang Gung Med J; 2002 Jun;25(6):399-404
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  • [Title] Undifferentiated sarcoma of the liver.
  • Undifferentiated (embryonal) sarcoma of the liver (USL) is a rare primary hepatic malignancy principally affecting patients of pediatric age.
  • Recently, long-term disease-free survival has been achieved in cases which underwent aggressive multimodal treatment.
  • Postoperative chemotherapy was recommended, but was refused by the patient's family.
  • A recurrent liver mass was found 171 days after the operation.
  • Chemotherapy was refused once again by the patient's family, and she was lost to follow-up for 5 months.
  • She was admitted and received chemotherapy with vincristine, ifosfamide, and cisplatin.
  • [MeSH-major] Liver Neoplasms / pathology. Sarcoma / pathology

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  • (PMID = 12173670.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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27. Michael H, Lucia J, Foster RS, Ulbright TM: The pathology of late recurrence of testicular germ cell tumors. Am J Surg Pathol; 2000 Feb;24(2):257-73
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  • A total of 91 men had histologically documented late recurrences of testicular germ cell tumors characterized by a complete response to treatment with a subsequent disease-free interval of at least 2 years and no evidence of a second primary lesion.
  • Ninety percent of the patients for whom information was available received chemotherapy shortly after their initial diagnosis of testicular germ cell tumors; most of the other patients were known to have stage I disease initially.
  • Thus, teratoma was the most common type of neoplasm in late recurrences.
  • Excluding teratoma coexisting with other types of neoplasms, yolk sac tumor was the most frequent type of tumor in patients with late recurrence.
  • It occurred in 47% of patients, either alone or with teratoma, another nonteratomatous germ cell tumor type, or a "nongerm cell malignant tumor."
  • Unusual types of yolk sac tumor, including glandular, parietal, clear cell, and pleomorphic patterns, were seen frequently in late recurrences and often raised differential diagnostic problems with "nongerm cell" carcinomas.
  • A smaller number of late recurrences consisted of other types of neoplasms.
  • Most of these nonteratomatous germ cell tumors other than yolk sac tumor were embryonal carcinoma, although rarely seminoma and choriocarcinoma were encountered.
  • "Nongerm cell malignant tumors," including both sarcomas and carcinomas of various types, occurred in 23% of late-recurrence patients, either alone or with a nonteratomatous germ cell tumor.
  • Late recurrences were seen in many different sites in these patients, including the retroperitoneum, abdomen, pelvis, liver, mediastinum, lung, bone (femur, vertebra, and rib), lymph nodes outside the retroperitoneum and mediastinum (supraclavicular, neck, and axillary regions), scrotum and inguinal regions, adrenal gland, chest wall, and buttocks.
  • Patients whose late recurrences consisted of pure "nongerm cell malignant tumor" or pure germ cell tumor (yolk sac tumor or other types) had a much worse prognosis: Only 36% to 37% were alive with no evidence of disease.
  • Patients with two different types of nonteratomatous malignancies in their late recurrences had a dismal clinical course: Only 17% with both yolk sac tumor and other nonteratomatous germ cell tumor had no evidence of disease, whereas no patient with both nonteratomatous germ cell tumor and "nongerm cell malignant tumor" was disease free.
  • Furthermore, late recurrence is not likely to respond to chemotherapy and is best treated by surgical excision when possible.
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Embryonal / complications. Carcinoma, Embryonal / pathology. Carcinoma, Embryonal / therapy. Choriocarcinoma / complications. Choriocarcinoma / pathology. Choriocarcinoma / therapy. Endodermal Sinus Tumor / complications. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / therapy. Fluorescent Antibody Technique, Direct. Humans. Male. Neoplasm Staging. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Sarcoma / complications. Sarcoma / pathology. Sarcoma / therapy. Seminoma / complications. Seminoma / pathology. Seminoma / therapy. Teratoma / complications. Teratoma / pathology. Teratoma / therapy

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  • (PMID = 10680894.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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28. Czauderna P, Popadiuk S, Korzon M, Stoba C, Szymik-Kantorowicz S, Sawicz-Birkowska K, Lopatka B, Bogusławska-Jaworska J, Kowalczyk J, Sopyło B, Madziara W, Juszkiewicz P, Swiatkiewicz V, Skotnicka-Klonowicz G, Włodarczyk A: Multicenter retrospective analysis of various primary pediatric malignant hepatic tumors--management in a series of 47 Polish patients (1985-1995). Eur J Pediatr Surg; 2001 Apr;11(2):82-5
MedlinePlus Health Information. consumer health - Liver Cancer.

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  • Forty-seven children treated in various Polish centers between 1985 and 1995 for primary malignant liver tumors were retrospectively analyzed.
  • There were 6 hepatocarcinoma (HCC) cases and 2 cases of undifferentiated sarcoma (UDS).
  • In 44% of HB patients the tumor involved both liver lobes.
  • 18% of children with HB presented with pulmonary metastases at diagnosis.
  • Chemotherapy was applied in 92% of cases (preoperatively in 67%).
  • Overall survival of patients with hepatoblastoma was 43.6%, while it was 50% for hepatocarcinoma and 100% for undifferentiated sarcoma (2 cases only).
  • Mean observation time was 58 months.
  • Involvement of both lobes of the liver and multifocality of the tumor were other adverse prognostic factors.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hepatoblastoma / surgery. Liver Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / surgery
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Poland / epidemiology. Retrospective Studies. Survival Rate

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  • (PMID = 11371041.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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29. Szumera M, Czauderna P, Popadiuk S, Renke J, Sznurkowska K, Gołebiewski J, Korzon M: [Pulmonary metastases in children with solid tumours--own experiences]. Med Wieku Rozwoj; 2006 Jul-Sep;10(3 Pt 1):665-75
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • At the moment of the diagnosis lung metastases were present in 19.2% of patients while in the rest (80.8%) occurred during and after treatment.
  • Secondary metastases in lungs occurred within 4-48 months after the diagnosis.
  • The after-surgery chemotherapy for tumour recurrence was introduced in each case.
  • RESULTS: In the analysed group 14 (53.8%) children are alive with the overall survival time 8-120 months.
  • The rest 12 (46.2%) are dead with the survival time 6-24 months.
  • Time of occurrence was statistically insignificant (p=0.26).
  • The active search for lung metastases at the moment of diagnosis, treatment and follow-up combined with complete surgery procedures may prolong survival.
  • There is a need to find new methods of lung metastases treatment.
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Carcinoma, Embryonal / secondary. Carcinoma, Embryonal / surgery. Carcinoma, Hepatocellular / secondary. Carcinoma, Hepatocellular / surgery. Child. Endocrine Gland Neoplasms / pathology. Endocrine Gland Neoplasms / surgery. Female. Follow-Up Studies. Humans. Liver Neoplasms / pathology. Liver Neoplasms / surgery. Male. Neuroblastoma / secondary. Neuroblastoma / surgery. Oncology Service, Hospital / statistics & numerical data. Osteosarcoma / secondary. Osteosarcoma / surgery. Poland. Prognosis. Retrospective Studies. Sarcoma, Ewing / secondary. Sarcoma, Ewing / surgery. Treatment Outcome

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  • (PMID = 17317898.001).
  • [Journal-full-title] Medycyna wieku rozwojowego
  • [ISO-abbreviation] Med Wieku Rozwoj
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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30. Almogy G, Pappo O, Gips M, Lieberman S, Edden Y, Eid A: Improved survival with surgery and systemic chemotherapy for undifferentiated embryonal sarcoma of the liver. Isr Med Assoc J; 2005 Oct;7(10):672-3
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improved survival with surgery and systemic chemotherapy for undifferentiated embryonal sarcoma of the liver.
  • [MeSH-major] Liver Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Female. Hepatectomy. Humans

  • Genetic Alliance. consumer health - Embryonal Sarcoma.
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  • (PMID = 16259353.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Israel
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