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Items 1 to 35 of about 35
1. Shamim M: Successful pregnancy outcome after fertility-sparing surgery and chemotherapy for dysgerminoma. J Pak Med Assoc; 2010 Sep;60(9):779-81
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  • [Title] Successful pregnancy outcome after fertility-sparing surgery and chemotherapy for dysgerminoma.
  • Ovarian dysgerminoma is a rare malignancy of the ovary.
  • This is a case report of a 30-year-old female, presenting with a huge ovarian mass along with multiple gallstones; she was treated by fertility-sparing excision of the mass and cholecystectomy, followed by chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dysgerminoma / therapy. Ovarian Neoplasms / therapy

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  • (PMID = 21381594.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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2. Tanaka Y, Fujiwara K, Yamauchi H, Mikami Y, Kohno I: Pregnancy in a woman with a Y chromosome after removal of an ovarian dysgerminoma. Gynecol Oncol; 2000 Dec;79(3):519-21
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  • [Title] Pregnancy in a woman with a Y chromosome after removal of an ovarian dysgerminoma.
  • Therefore, it is recommended that patients with dysgerminoma of the ovary associated with the XY karyotype should undergo a bilateral salpingo-oophorectomy.
  • CASE: We report an extremely rare case of a true hermaphrodite with a 20% 46,XX/80% 46,XY karyotype who became pregnant after removal of an ovarian dysgerminoma.
  • A dysgerminoma with ovotestis was found in the right ovary.
  • Two courses of chemotherapy following a right salpingo-oophorectomy were carried out.
  • CONCLUSION: A unilateral salpingo-oophorectomy followed by combination chemotherapy can be the treatment of choice for any woman who wishes to preserve her capacity for conception at the time of operation for dysgerminoma of the ovary.
  • [MeSH-major] Disorders of Sex Development / genetics. Dysgerminoma / surgery. Ovarian Neoplasms / surgery. Pregnancy Complications, Neoplastic / etiology

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  • [Copyright] Copyright 2000 Academic Press.
  • (PMID = 11104633.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
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3. Jeyakumar A, Cabeza R, Hindenburg A: Late recurrence in ovarian dysgerminoma with successful response to standard adjuvant chemotherapy: a case report and review of the literature. Gynecol Oncol; 2001 May;81(2):314-7
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  • [Title] Late recurrence in ovarian dysgerminoma with successful response to standard adjuvant chemotherapy: a case report and review of the literature.
  • BACKGROUND: Ovarian dysgerminomas are quite amenable to treatment and very good cure rates are achieved even with advanced disease.
  • However, recent literature suggests that late recurrence may be associated with a poorer prognosis and bleomycin/etoposide/cisplatin (BEP) chemotherapy may play only a limited role in its management.
  • We present a patient who had a late recurrence of ovarian dysgerminoma with successful treatment outcome.
  • CASE: A 25-year-old woman was diagnosed with a stage IC ovarian dysgerminoma in 1983 and did not undergo adjuvant treatment.
  • She had late recurrence 12 years later with good treatment response to BEP chemotherapy given in a semiadjuvant fashion.
  • CONCLUSION: Our case demonstrates that BEP chemotherapy still plays an important role in treatment of late recurrence in ovarian dysgerminomas provided there is small volume disease at time of detection.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dysgerminoma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Ovarian Neoplasms / drug therapy
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Neoplasm Staging

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  • [Copyright] Copyright 2001 Academic Press.
  • (PMID = 11330968.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
  • [Number-of-references] 14
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4. Ivanaj A, Pautier P, Rixe O, Duvillard P, Dubard T: Peripheral neuropathy in association with an ovarian dysgerminoma. Gynecol Oncol; 2003 Apr;89(1):168-70
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  • [Title] Peripheral neuropathy in association with an ovarian dysgerminoma.
  • BACKGROUND: Peripheral neuropathy among women with ovarian dysgerminoma has not been so far reported in the literature.
  • CASE: We report a case of an 18-year-old woman with an association of an abdominal relapse of an ovarian dysgerminoma and a polyradiculoneuritis.
  • The normality of neurologic investigations and the disappearance of all sensitive and muscular alterations after tumor ablation and one cycle of chemotherapy are in favor of a paraneoplastic syndrome.
  • CONCLUSION: We describe the first case of a polyradiculoneuritis associated with an ovarian dysgerminoma.
  • The evolution of the paraneoplastic syndrome was favorable after treatment of the tumor.
  • [MeSH-major] Dysgerminoma / complications. Ovarian Neoplasms / complications. Paraneoplastic Polyneuropathy / complications. Polyradiculoneuropathy / complications

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  • (PMID = 12694672.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Ramírez Torres N, Basavilvazo Rodríguez MA, Téllez Márquez A, Robles Robles G, Lemus Rocha R, Hernández Valencia M: [Clinical experience with chemotherapy of the malignant tumor of germinal cells (dysgerminoma) of the ovary]. Ginecol Obstet Mex; 2004 Oct;72:500-7
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  • [Title] [Clinical experience with chemotherapy of the malignant tumor of germinal cells (dysgerminoma) of the ovary].
  • [Transliterated title] Experiencia clínica con el tratamiento a base de quimioterapia del tumor maligno de células germinales (disgerminoma) del ovario.
  • OBJECTIVE: To evaluate two alternative plans of chemotherapy with EP (etoposide, platinum) and BEP (bleomycin, etoposide, platinum) after oncological surgery.
  • MATERIAL AND METHODS: A clinical, longitudinal and descriptive study was done, where the cases with pure dysgerminoma diagnosed in the gynecology-oncology service during the years from 1992 to 2003 were included.
  • Histological study confirmed the pure dysgerminoma, with a mean duration of the symptoms of 5.2 months, the free survival of disease was of 39.6 months and general survival was of 49.5 months.
  • It was administered early chemotherapy in 11 patients, from which 7 received EP and the other 4 received BEP.
  • There were 3 patients rescued with chemotherapy of second line and a patient with radiotherapy to central nervous system.
  • The statistical analysis showed that size of tumor among the recurrent group (24.2 cm) and the group without recurrence (14.5 cm) had significant differences (p = 0.018), the size of the tumor and the free survival of disease did not have significant correlation (p = 0.99), but upon comparing the general survival with the phase of the disease, a significant correlation was found (p = 0.03), where the survival to 5 years was observed in 6 cases (33.3%), of which a case was treated with surgery and without chemotherapy, 4 cases with EP and a case with BEP.
  • [MeSH-major] Dysgerminoma / drug therapy. Ovarian Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Longitudinal Studies. Survival Rate. Time Factors

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  • (PMID = 15790190.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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6. Zuntová A, Sumerauer D, Teslík L, Koutecký J: [Ovarian dysgerminoma in children and adolescents. Retrospective clinico-pathologic study]. Cas Lek Cesk; 2004;143(4):246-52
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  • [Title] [Ovarian dysgerminoma in children and adolescents. Retrospective clinico-pathologic study].
  • BACKGROUND: To review the treatment strategy, follow up and outcome for all patients with pure ovarian dysgerminoma treated in childhood and adolescence.
  • METHODS AND RESULTS: Twenty-one patients younger than 18 years were treated between 1979-2002 in Faculty Hospital Motol for newly diagnosed pure ovarian dysgerminoma.
  • The median age at the time of diagnosis was 12.5 years (range 6 years, 5 months--17 years, 11 months).
  • All patients, except two girls with bilateral dysgerminoma, underwent unilateral adnexectomy or ovarectomy.
  • Ten girls were treated postoperatively with chemotherapy, eight with chemotherapy and radiotherapy (eleven with cisplatine based chemotherapy).
  • Three girls with dysgerminoma confined to the ovary (stage IA) have not received adjuvant chemotherapy.
  • Majority of patients does not have severe treatment sequelae, three pregnancies have occurred so far.
  • CONCLUSIONS: Most patients with dysgerminoma, including those with metastases can expect cure when treated with conservative surgery and cisplatine based chemotherapy.
  • Reduction of treatment toxicity and preservation of reproductive function is a main task.
  • The girls with dysgerminoma confined to the ovary (stage IA) can be treated with fertility sparing surgery, other should be treated with cisplatine based chemotherapy.
  • [MeSH-major] Dysgerminoma. Ovarian Neoplasms

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  • (PMID = 15218724.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
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7. Kdous M, Hachicha R, Gamoudi A, Boussen H, Benna F, Rahal K: [Pure dysgerminoma of the ovary. 12 case reports]. Tunis Med; 2003 Dec;81(12):937-43
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  • [Title] [Pure dysgerminoma of the ovary. 12 case reports].
  • [Transliterated title] Les dysgerminomes ovariens purs. A propos de 12 cas.
  • Data from the files of 12 patients with pur ovarian dysgerminoma managed between January 1970 and december 1990 were evaluated.
  • Pur ovarian dysgerminoma accounts for 2% of all ovarian malignancies and 28% of malignant germ cell tumors.
  • Echography objective ovarian tumor in all cases.
  • Diagnosis was histological.
  • Primary treatment was surgery followed by radiotherapy in 8 cases and chemotherapy in 2 cases.
  • 2 patients developed local recurrences were irradiated and 1 patient developed distant metastases was given chemotherapy in association to radiotherapy.
  • CONCLUSION: Treatment of ovarian dysgerminoma remains controversial.
  • For all other patients, radical surgery followed by radiation therapy or chemotherapy for the advanced stages and recurrents dysgerminoma is the treatment of choice.
  • Prospective randomized clinical trials are needed for a well codified therapeutic strategy.
  • [MeSH-major] Dysgerminoma / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Female. Humans. Infertility, Female / etiology. Middle Aged. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • (PMID = 14986529.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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8. Li YF, Li MD, Wu QL, Liu FY, Li JD, Zou JL, Huang YW: [Clinical analysis of 57 patients with ovarian dysgerminoma]. Ai Zheng; 2002 Jan;21(1):79-82
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  • [Title] [Clinical analysis of 57 patients with ovarian dysgerminoma].
  • BACKGROUND & OBJECTIVE: Ovarian dysgerminoma is an uncommen ovarian malignancy.
  • The aim of this study is to investigate the clinical features and factors related to prognosis of ovarian dysgerminoma.
  • METHOD: The data of 57 patients with pure Ovarian Dysgerminoma were analyzed retrospectively, who were admitted to Cancer Center, Sun Yat-sen University of Medical Sciences from January 1, 1964 to December 31, 2000.
  • Combined modality was given to 52 cases and single-method treatment 5 cases.
  • Of 23 patients in stage I group to whom only chemotherapy were given after operation, 19 cases received 3 or more courses and were well being without recurrence; four patients received only one course and one of them recurred 21 months after operation.
  • In the group of stage II and III cases the 5-year survival rate was 86.7% for those whose chemotherapy courses were > or = 4 and 25.0% for patients who received less than 4 courses of chemotherapy (P < 0.05).
  • CONCLUSIONS: The prognosis of ovarian dysgerminoma is closely related to disease stage and modality of treatment.
  • [MeSH-major] Dysgerminoma / therapy. Ovarian Neoplasms / therapy

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  • (PMID = 12500404.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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9. Hubalek M, Smekal-Schindelwig C, Zeimet AG, Sergi C, Brezinka C, Mueller-Holzner E, Marth C: Chemotherapeutic treatment of a pregnant patient with ovarian dysgerminoma. Arch Gynecol Obstet; 2007 Aug;276(2):179-83
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  • [Title] Chemotherapeutic treatment of a pregnant patient with ovarian dysgerminoma.
  • BACKGROUND: Diagnosis of malignant ovarian tumours during pregnancy is uncommon.
  • This report presents a case of a pregnant woman with ovarian dysgerminoma.
  • CASE REPORT: At 24 weeks gestation, a 33-year-old patient was diagnosed with unilateral ovarian dysgerminoma.
  • After surgery, she received three additional cycles of chemotherapy in an adjuvant setting.
  • CONCLUSION: This case report illustrates the difficulties arising from diagnosis of malignancy during pregnancy.
  • Although combined treatment with paclitaxel and carboplatin is not considered a first-line therapy for ovarian dysgerminoma, in this case report it elicited an excellent response, and there were no adverse effects on the foetus.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Germinoma / drug therapy. Ovarian Neoplasms / drug therapy. Pregnancy Complications, Neoplastic / drug therapy

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  • (PMID = 17342499.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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10. Vicus D, Beiner ME, Klachook S, Le LW, Laframboise S, Mackay H: Pure dysgerminoma of the ovary 35 years on: a single institutional experience. Gynecol Oncol; 2010 Apr;117(1):23-6
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  • [Title] Pure dysgerminoma of the ovary 35 years on: a single institutional experience.
  • OBJECTIVE: The aim of this study was to evaluate clinicopathologic characteristics, long-term outcome and reproductive function in women diagnosed with pure dysgerminoma of the ovary.
  • METHODS: Sixty-five women with stage IA to IIIC pure ovarian dysgerminoma were identified and included in this retrospective study.
  • RESULTS: Median age at diagnosis was 22.2 years (range 8.2-64.1 years).
  • Seventeen patients received chemotherapy (15 adjuvant, 2 for residual disease), 20 received adjuvant radiotherapy and one patient received both.
  • All recurrences occurred within 19 months of primary diagnosis.
  • All patients were successfully salvaged with radiotherapy (2 patients), chemotherapy (1 patient) or a combination of surgery and chemotherapy (3 patients).
  • Overall, median follow up from time of recurrence was 22.5 years (range 9.3-31.4 years).
  • CONCLUSION: The long-term outcome of patients with pure ovarian dysgerminoma is excellent.
  • Recurrences occur within 2 years of diagnosis and are treatable.
  • [MeSH-major] Dysgerminoma / pathology. Dysgerminoma / therapy. Ovarian Neoplasms / pathology. Ovarian Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Child. Combined Modality Therapy. Disease-Free Survival. Female. Fertility. Humans. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Retrospective Studies. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 20097412.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. David YB, Weiss A, Shechtman L, Shalev E: Tumor chemoconversion following surgery, chemotherapy, and normalization of serum tumor markers in a woman with a mixed type germ cell ovarian tumor. Gynecol Oncol; 2002 Mar;84(3):464-7
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  • [Title] Tumor chemoconversion following surgery, chemotherapy, and normalization of serum tumor markers in a woman with a mixed type germ cell ovarian tumor.
  • BACKGROUND: Malignant germ cell tumors of the ovary are often curative after conservative surgery and adjuvant chemotherapy.
  • Persistent tumors despite normalization of serum tumor markers may represent retroconversion to benign masses, but this is rare in ovarian tumors without teratoma elements.
  • CASE: A young woman with a stage IIIC mixed germ cell ovarian tumor containing endodermal and dysgerminoma elements and elevated serum tumor markers underwent conservative surgery followed by chemotherapy.
  • The residual tissue was resected and contained benign tissue.
  • CONCLUSIONS: In cases where masses persist and serum tumor markers normalize, attaining a histological diagnosis, and not chemotherapy, should be considered.
  • [MeSH-major] Biomarkers, Tumor / blood. Germinoma / drug therapy. Germinoma / surgery. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Female. Humans

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  • (PMID = 11855890.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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12. Vicus D, Beiner M, Klachook S, Le L, Ginsburg O, Laframboise S, Mackay H: Dysgerminoma of the ovary 35 years on: A single institutional experience. J Clin Oncol; 2009 May 20;27(15_suppl):e16523

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dysgerminoma of the ovary 35 years on: A single institutional experience.
  • : e16523 Background: Ovarian dysgerminomas are rare but are relatively more common in women under 20 years of age in whom fertility is likely to be an issue.
  • The aim of this study was to review our institutional experience in treating patients (pts) diagnosed with pure dysgerminoma.
  • METHODS: We performed a retrospective chart review of all pts diagnosed with ovarian dysgerminoma at the Princess Margaret Hospital, Toronto, between 1970 and 2005.
  • RESULTS: 65 pts were diagnosed with ovarian dysgerminoma, median age 21.9 years (range 8.1-64.1 yrs).
  • 17 pts received chemotherapy, 15 adjuvant and 2 for residual disease (all post 1988); 8 for stage I, 1 for stage II, and 8 for stage III.
  • 1 pt received a combination of adjuvant chemotherapy and radiation.
  • 6 (9.2%) pts recurred all within 19 months of initial diagnosis.
  • Treatment of recurrent disease was by salvage surgery and chemotherapy (3 pts), radiotherapy (2 pts), and EP (1 pt).
  • All pts who recurred responded to treatment and were alive at last follow up, median follow up 22.5 yrs (range 9.3-31.4 yrs).
  • 15 pts attempted to conceive posttreatment; 6 had received adjuvant treatment; 4 EP; and 2 whole abdominal radiotherapy.
  • CONCLUSIONS: The long-term outcome of patients with an ovarian dysgerminoma is excellent.
  • Recurrences occured within 2 years of diagnosis and are treatable.

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  • (PMID = 27960796.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Varras M, Tsikini A, Polyzos D, Samara Ch, Akrivis Ch: Internal hemorrhage caused by a twisted malignant ovarian dysgerminoma: ultrasonographic findings of a rare case and review of the literature. Clin Exp Obstet Gynecol; 2004;31(1):73-8
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  • [Title] Internal hemorrhage caused by a twisted malignant ovarian dysgerminoma: ultrasonographic findings of a rare case and review of the literature.
  • PURPOSE: Ovarian cancer presents as an acute abdomen very rarely.
  • The purpose of the study is the description of a right ovarian malignant dysgerminoma presenting as an abdominal emergency.
  • The uterus and the left ovary had normal size and echo-texture.
  • Fluid was found in the cul-de-sac and in Morisson's space.
  • An immediate exploratory laparotomy exposed the presence of a twisted right ovarian mass and intraperitoneal hemorrhage.
  • The intra-abdominal hemorrhage ceased when the ovarian pedicle was clamped.
  • Pathologic analysis revealed a malignant dysgerminoma of the right ovary, expanding to the mesosalpinx.
  • The patient was assigned to FIGO Stage IIC and referred for platinum-based chemotherapy.
  • CONCLUSION: Ovarian malignant dysgerminoma may present as an acute abdomen because of torsion, passive blood congestion, rupture of superficial tumoral vessels and subsequent intra-abdominal hemorrhage.
  • Ovarian dysgerminoma should be part of the differential diagnosis in a young woman with acute surgical abdomen and a solid heterogeneous pelvic mass detected by ultrasonographic scan.
  • [MeSH-major] Abdomen, Acute / etiology. Dysgerminoma / complications. Hemoperitoneum / etiology. Ovarian Neoplasms / complications

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  • (PMID = 14998196.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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14. Takemori M, Ichimura T, Nishimura R, Hasegawa K: Ovarian dysgerminoma with massive metastases to para-aortic lymph nodes. Gynecol Obstet Invest; 2000;49(3):211-3
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  • [Title] Ovarian dysgerminoma with massive metastases to para-aortic lymph nodes.
  • We report on a 15-year-old female with left ovarian dysgerminoma accompanied by massive swelling of the para-aortic lymph nodes which was clearly demonstrated by preoperative magnetic resonance imaging (MRI).
  • Metastasis to the para-aortic lymph nodes from dysgerminoma was confirmed by biopsies obtained during surgery.
  • No study has previously reported dysgerminoma with massive para-aortic lymph node metastases clearly demonstrated by MRI.
  • The patient received six cycles of cisplatin-based combination chemotherapy with the BEP regimen (bleomycin, etoposide and cisplatin) after conservative surgery, and no residual para-aortic lymph nodes were detected by MRI or CT after the chemotherapy.
  • [MeSH-major] Dysgerminoma / secondary. Lymphatic Metastasis. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Aorta. Biopsy. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Magnetic Resonance Imaging

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  • [Copyright] Copyright 2000 S. Karger AG, Basel
  • (PMID = 10729765.001).
  • [ISSN] 0378-7346
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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15. Ishibashi M, Nakayama K, Oride A, Yeasmin S, Katagiri A, Iida K, Nakayama N, Miyazaki K: [A case of PEP(BEP)-resistant ovarian dysgerminoma successfully treated by VeIP therapy]. Gan To Kagaku Ryoho; 2009 Mar;36(3):513-7
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  • [Title] [A case of PEP(BEP)-resistant ovarian dysgerminoma successfully treated by VeIP therapy].
  • Ovarian germ cell tumors are malignant tumors which commonly develop during childhood, and which are sensitive to chemotherapy.
  • We have had a case of germ cell tumors which showed resistance to first-line PEP(BEP)chemotherapy.
  • As second-line chemotherapy, VeIP therapy was used, because it is possible that this therapy is effective against recurrent testicular germ cell tumors.
  • She experienced acute abdominal pain and visited the hospital, where she was diagnosed with torsion of an ovarian tumor.
  • An emergency laparotomy and right salpingoophorectomy were performed, the pathological diagnosis being stage Ia ovarian dysgerminoma G1.
  • An MRI revealed an abnormal signal in the left ovary, so we diagnosed this as a recurrence of the dysgerminoma.
  • Then she received chemotherapy PEP(BEP), but after eight months of PEP (BEP), her serum hCG-CTP was again elevated to 14.5 mIU/mL.
  • The recurrent region was detected in the left ovary.
  • A left ovarian cystectomy was performed in which CDDP ip was used.
  • After the operation, the patient again underwent chemotherapy.
  • After 6 courses of this therapy, she had a follow-up operation.
  • She remains without recurrence of this disease 24 months after VeIP therapy.
  • This case suggests that VeIP therapy might be an effective second-line therapy for patients with PEP(BEP)-resistant ovarian dysgerminoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Drug Resistance, Neoplasm / drug effects. Dysgerminoma / drug therapy. Dysgerminoma / pathology. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Bleomycin / therapeutic use. Cisplatin / therapeutic use. Female. Humans. Magnetic Resonance Imaging. Positron-Emission Tomography. Remission Induction. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19295284.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; Q20Q21Q62J / Cisplatin
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16. Prado S, Yazigi R, Garrido J, Gonzalez M, Torres R, Oddo D: Recurrent ovarian dysgerminoma after laparoscopy. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:397-9
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  • [Title] Recurrent ovarian dysgerminoma after laparoscopy.
  • To our knowledge, recurrent dysgerminoma at the site of tumor removal by laparoscopy in a patient with stage IA disease has not been previously reported.
  • A woman with ovarian dysgerminoma treated by laparoscopy and tumor removed through the cul-de-sac recurred the 17 months later at the site of tumor removal.
  • She was successfully treated with etoposide, bleomycin, and cisplatin chemotherapy with complete response.
  • This case illustrates the potential for surgical site implant of an ovarian dysgerminoma; surgeons should follow strict guidelines when performing laparoscopic procedures for ovarian malignancies in order to prevent this type of incident.
  • [MeSH-major] Dysgerminoma / therapy. Gynecologic Surgical Procedures / adverse effects. Laparoscopy / adverse effects. Neoplasm Recurrence, Local. Ovarian Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Remission Induction

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  • (PMID = 16515632.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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17. Desirotte G, Pintiaux A, Foidart JM, Nisolle M: [Four clinical cases of dysgerminoma]. Rev Med Liege; 2008 Sep;63(9):523-7
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  • [Title] [Four clinical cases of dysgerminoma].
  • [Transliterated title] Le cas clinique du mois. Quatre cas de dysgerminomes.
  • Dysgerminoma is an ovarian germ cell tumor occurring more frequently among young women.
  • The efficacy of chemotherapy allows conservative surgery sparing fertility.
  • A stadification surgery will avoid chemotherapy for patients with stage Ia.
  • A ct-scan is performed twice a year and, in case of recurrence, a first or a second chemotherapy should be prescribed.
  • [MeSH-major] Dysgerminoma. Ovarian Neoplasms

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  • (PMID = 19051506.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
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18. Guillem V, Poveda A: Germ cell tumours of the ovary. Clin Transl Oncol; 2007 Apr;9(4):237-43
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  • [Title] Germ cell tumours of the ovary.
  • Germinal cell tumours represent only 2-5% of all cancers of the ovary.
  • Neither the prognosis nor the treatment of these tumours is homogeneous; the low incidence is the reason it is hard to develop prospective studies for establishing prognostic factors and specific treatments.
  • The introduction of adjuvant chemotherapy into initial surgery has improved the prognosis of these patients.
  • The surgical treatment demands the application of the same principles seen in cytoreduction surgery of epithelial cancers of the ovary (maximum possible cytoreduction), though in many cases hysterectomy and double adnexectomy may be obviated.
  • In view of the rarity of these tumours, it is advisable to work within cooperative groups that may have subgroups for the treatment of rare tumours.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal. Ovarian Neoplasms
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor. Carcinoma, Embryonal / diagnosis. Carcinoma, Embryonal / drug therapy. Carcinoma, Embryonal / pathology. Child. Choriocarcinoma / diagnosis. Choriocarcinoma / drug therapy. Choriocarcinoma / pathology. Chorionic Gonadotropin, beta Subunit, Human. Dysgerminoma / diagnosis. Dysgerminoma / drug therapy. Dysgerminoma / pathology. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / pathology. Female. Humans. Neoplasm Staging. Ovary / pathology. Prognosis. Randomized Controlled Trials as Topic. Teratoma / diagnosis. Teratoma / drug therapy. Teratoma / pathology. World Health Organization. alpha-Fetoproteins

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  • (PMID = 17462976.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
  • [Number-of-references] 49
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19. Ayhan A, Bildirici I, Günalp S, Yuce K: Pure dysgerminoma of the ovary: a review of 45 well staged cases. Eur J Gynaecol Oncol; 2000;21(1):98-101
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  • [Title] Pure dysgerminoma of the ovary: a review of 45 well staged cases.
  • PURPOSE: To evaluate the significance of meticulous surgical staging, and whether type of initial surgery or adjuvant therapy impacted on survival in cases of pure ovarian dysgerminoma.
  • METHODS: Retrospective chart review of 45 patients treated for pure ovarian dysgerminoma at a single institute.
  • RESULTS: Of the 45 patients subjected to a surgical staging procedure 30 (67%) had stage I disease, 2 (4%) had stage II, 9 (20%) had stage III, and 4 (9%) had stage IV pure ovarian dysgerminoma.
  • With a median follow-up of 61 months, the overall survival rate for ovarian dysgerminoma in this series was 84%.
  • Significantly lower survival rates were found in patients with advanced stage (stage III-IV) ovarian dysgerminoma (53.9%), when compared with earlier stages (96.9%).
  • As regards recurrence or survival rate, no significant difference was found between patients who were treated conservatively or nonconservatively, whether or not adjuvant chemotherapy or radiotherapy was given.
  • CONCLUSION: After careful surgical staging and confirming unilateral disease, conservative surgery, followed if necessary by adjuvant chemotherapy, seems to be the ideal treatment in cases of pure ovarian dysgerminoma.
  • [MeSH-major] Dysgerminoma / pathology. Neoplasm Staging. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Risk Assessment. Survival Analysis

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  • (PMID = 10726633.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ITALY
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20. Rajbhandari S, Shrestha B, Karki A: Diagnostic dilemma of an unusual pelvic mass in a young girl. JNMA J Nepal Med Assoc; 2007 Oct-Dec;46(168):199-202
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  • Dysgerminoma of ovary is the most common germ cell tumor, accounting for 50% of all germ cell tumor cases.
  • It is rare to find both ovaries to be involved in germ cell tumors.
  • The prognosis of patients with malignant germ cell has improved significantly over the last two decades after the introduction of chemotherapy specially cisplatin.
  • The only exceptions are stage 1, grade 1, immature teratoma and stage 1A dysgerminoima who are followed up after surgery without adjuvant chemotherapy.
  • Normal ovarian functions and fertility can be retained in most patients by following the conservative surgery.
  • [MeSH-major] Dysgerminoma / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Laparotomy. Ovariectomy / methods

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  • (PMID = 18340374.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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21. Novoa Vargas A: [Germinal cancer of the ovary and pregnancy]. Ginecol Obstet Mex; 2001 Jul;69:282-7
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  • [Title] [Germinal cancer of the ovary and pregnancy].
  • [Transliterated title] Cáncer germinal de ovario y embarazo.
  • The association of ovarian cancer with pregnancy, in a young patient with acute abdominal syndrome was reviewed.
  • The prognosis is related to early diagnosis and the stage, therefore ultrasonography is the corner stone to detect these tumors allowing a conservative management, mainly when the fertility must be maintained in younger patients.
  • Chemotherapy is an excellent adjuvant in the midtrimester and can be administered without an important deleterious effect on the fetus.
  • [MeSH-major] Dysgerminoma. Ovarian Neoplasms. Pregnancy Complications, Neoplastic. Teratoma

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  • (PMID = 11588812.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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22. Zuntová A, Sumerauer D, Teslík L, Kabícková E, Koutecký J: [Mixed germ cell tumours of the ovary in childhood and adolescence]. Cesk Patol; 2004 Jul;40(3):92-101
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  • [Title] [Mixed germ cell tumours of the ovary in childhood and adolescence].
  • Mixed germ cell tumours of the ovary are rare malignant neoplasms containing combinations of two or more types of germ cell elements.
  • The aim of the study was to review biopsy examinations, medical records, treatment strategy, follow-up and outcome of all girls treated for mixed germ cell tumour of the ovary at the Department of Pediatric Oncology, University Hospital Motol during the period 1979-2002.
  • The clinical data on surgical treatment, chemotherapy and radiotherapy used and follow-up information were obtained in all girls.
  • Sixteen girls with mixed germ cell tumour of the ovary, age range 3 years 11 months to 17 years 8 months (median 12 years) were treated.
  • All girls presented with unilateral tumour of the ovary and all underwent surgery as an initial treatment.
  • The original diagnosis of mixed histology was confirmed in all cases; in five cases the tumour contained three histologic components, in eleven cases the tumour consisted of two germ cell types.
  • All tumours contained elements of yolk sac tumour, followed by immature teratoma, embryonal carcinoma, dysgerminoma and mature teratoma.
  • At the time of diagnosis three patients had stage I disease, four patients stage II, seven stage III and two stage IV disease.
  • All patients were treated with chemotherapy after surgery, predominantly with platinum-based regimens (PVB, BEP).
  • Overall survival and event-free survival were 80% and 81.3% respectively (median follow-up time 7.6 years).
  • Three patients have died from the disease, two progressed on treatment (MAC), one girl relapsed three months after finishing therapy, no further therapy was administered.
  • One girl underwent resection of tumour of her remaining ovary 24 months after original diagnosis.
  • Microscopic examination should be extensive and careful to find out all types of malignant germ cell elements.
  • Platinum based chemotherapy is effective in the management of children and adolescents with mixed germ cell tumors of the ovary.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 15493415.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
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23. Mohammadianpanah M, Omidvari S, Mosalaei A, Ahmadloo N: Cisplatin-induced hypokalemic paralysis. Clin Ther; 2004 Aug;26(8):1320-3
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  • INTRODUCTION: Profound hypokalemic conditions resulting from cisplatin therapy have been known to produce hypokalemic paralysis in rare cases.
  • CASE SUMMARY: A 15-year-old Persian girl with ovarian dysgerminoma presented with severe generalized weakness and paraplegia 1 week after the fourth course of cisplatin-based chemotherapy.
  • DISCUSSION: Adverse drug reactions are common with cisplatin, but the drug is only rarely associated with hypokalemic paralysis.
  • This adverse drug event--whether isolated or secondary to hypomagnesemia--may be deceptive, leading to a fatal mistake in the oncology setting, and should therefore be precisely differentiated from cancer-related complications.
  • Regular serum electrolyte measurement, the early detection of cation deficiency, and appropriate replacement of cations are all recommended.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Cisplatin / adverse effects. Hypokalemic Periodic Paralysis / chemically induced. Hypokalemic Periodic Paralysis / diagnosis
  • [MeSH-minor] Adolescent. Blood Chemical Analysis. Diagnosis, Differential. Dysgerminoma / drug therapy. Female. Humans. Ovarian Neoplasms / drug therapy. Potassium / administration & dosage

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  • (PMID = 15476912.001).
  • [ISSN] 0149-2918
  • [Journal-full-title] Clinical therapeutics
  • [ISO-abbreviation] Clin Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; RWP5GA015D / Potassium
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24. Palenzuela G, Martin E, Meunier A, Beuzeboc P, Laurence V, Orbach D, Frappaz D: Comprehensive staging allows for excellent outcome in patients with localized malignant germ cell tumor of the ovary. Ann Surg; 2008 Nov;248(5):836-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comprehensive staging allows for excellent outcome in patients with localized malignant germ cell tumor of the ovary.
  • BACKGROUND: The management of malignant germ cell tumors of the ovary (OMGCT) requires multidisciplinary expertise.
  • PATIENTS AND METHODS: Data concerning diagnosis, surgery, and medical decisions were reviewed for all patients seen for postoperative management of OMGCT at the Centre Léon Bérard in Lyon and the Institut Curie in Paris between 1985 and 2003.
  • Sixty patients aged 0.4 to 27.9 years (mean 12.8 years) at diagnosis were included.
  • Relapses occurred in 8 of 24 stage I tumors that were observed (0/8 stage Ia; 5/13 stage Ix (P = 0.044) and 3/3 stage Ic) versus 0/14 stage I treated by adjuvant chemotherapy (P = 0.0015).
  • There was no significant prognostic value for age, stage, level of tumor markers at diagnosis, type of surgery, and type of chemotherapy.
  • Patients with stages Ix and Ic tumors may benefit from adjuvant chemotherapy.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. Child. Dysgerminoma / diagnosis. Dysgerminoma / surgery. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / surgery. Fallopian Tubes / surgery. Female. Humans. Neoplasm Staging. Ovariectomy. Radiotherapy, Adjuvant. Retrospective Studies. Teratoma / diagnosis. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 18948812.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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25. Kasenda B, Harter P, Hirsch T, Ast A, Buhrmann C, Glaser F, Du Bois A: Para-aortic lymph node metastasis in malignant dysgerminoma of the ovary. Acta Obstet Gynecol Scand; 2009;88(11):1288-90
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  • [Title] Para-aortic lymph node metastasis in malignant dysgerminoma of the ovary.
  • Dysgerminomas comprise approximately 2-5% of all ovarian malignancies and mostly affect young adolescent women.
  • Primary comprehensive surgery and adjuvant chemotherapy consisting of bleomycin, etoposide, and cisplatin (BEP) are the current recommended treatment options, the latter reserved for advanced stages (FIGO II-IV).
  • Both were subsequently diagnosed with recurrent malignant dysgerminoma and para-aortic lymph node metastasis.
  • Neither had received comprehensive staging at initial surgery nor adjuvant radio or chemotherapy.
  • Both needed extensive surgery and multiagent chemotherapy for survival and belong to the small percentage of FIGO IA dysgerminoma patients showing a relapse.
  • Comprehensive initial surgery including systematic para-aortic lymphadenectomy and adjuvant chemotherapy at tertiary referral centers is needed to minimize the treatment burden.
  • [MeSH-major] Dysgerminoma / secondary. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / therapeutic use. Cisplatin / therapeutic use. Etoposide / therapeutic use. Female. Humans. Lymphatic Metastasis. Young Adult

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  • (PMID = 19900144.001).
  • [ISSN] 1600-0412
  • [Journal-full-title] Acta obstetricia et gynecologica Scandinavica
  • [ISO-abbreviation] Acta Obstet Gynecol Scand
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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26. Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT, Korean Gynecologic Oncology Group: Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study. Int J Gynecol Cancer; 2009 Jan;19(1):84-7
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  • [Title] Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
  • We evaluated the clinicopathologic characteristics of malignant germ cell tumors in the ovaries of South Korean women and determined the prognostic factors affecting recurrence.
  • Histologically, immature teratoma was the most common tumor type (n = 68), followed by dysgerminoma (n = 54), endodermal sinus tumor (n = 38), mixed form (n = 24), and choriocarcinoma (n = 12).
  • Postoperative chemotherapy was administered in 166 patients, and the most common regimen was bleomycin, etoposide, and cisplatin (n = 120).
  • The results of this study demonstrate that most malignant germ cell tumors of the ovary in Korean women are detected in the early stage and have excellent survival outcomes with conservative operation and platinum-based chemotherapy.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 19258947.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Investigator] Lee JK; Park JJ; Cha MS; Kim JH; Lee JM; Park SY; Kim SC; Lee SK
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27. Boran N, Tulunay G, Caliskan E, Köse MF, Haberal A: Pregnancy outcomes and menstrual function after fertility sparing surgery for pure ovarian dysgerminomas. Arch Gynecol Obstet; 2005 Feb;271(2):104-8
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  • [Title] Pregnancy outcomes and menstrual function after fertility sparing surgery for pure ovarian dysgerminomas.
  • MATERIALS AND METHODS: The medical records of 23 patients with pure ovarian dysgerminoma treated by conservative surgery at SSK Ankara Maternity Hospital between 1991 and 2001 were reviewed retrospectively.
  • Wedge biopsy of contralateral ovary was performed in 17 patients (74%) and tumor was diagnosed in 2 (11.7%).
  • Adjuvant chemotherapy was applied in 16 (70%) of the cases.
  • The sites of recurrences were contralateral ovary in all cases.
  • Three of the primiparous patients delivered after treatment.
  • Five pregnancies occurred in 3 nulliparous patients at the time of primary surgery.
  • CONCLUSION: Fertility sparing treatments are safe in patients with pure ovarian dysgerminoma.
  • [MeSH-major] Dysgerminoma / surgery. Fertility. Menstruation. Ovarian Neoplasms / surgery. Ovariectomy / methods
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Female. Humans. Neoplasm Staging. Pregnancy. Pregnancy Outcome. Retrospective Studies

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  • (PMID = 15007601.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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28. Lu KH, Gershenson DM: Update on the management of ovarian germ cell tumors. J Reprod Med; 2005 Jun;50(6):417-25
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  • [Title] Update on the management of ovarian germ cell tumors.
  • Malignant germ cell tumors of the ovary are rare.
  • In contrast to epithelial ovarian cancer, malignant germ cell tumors occur primarily in girls and young women.
  • In a girl or young woman who presents with a pelvic mass, a gynecologist must consider the diagnosis of an ovarian germ cell tumor in the initial workup.
  • Elevated tumor markers may assist in determining the diagnosis preoperatively.
  • Appropriate intraoperative decision making is crucial to adequately treat and stage the cancer without compromising future fertility.
  • For patients with stage I dysgerminoma or stage I low grade immature teratoma, no additional chemotherapy is indicated.
  • However, patients with stage I disease of other germ cell histologies, as well as advanced-stage disease of all germ cell histologies, require adjuvant treatment with bleomycin, etoposide and cisplatin.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Fertility. Germinoma / drug therapy. Ovarian Neoplasms / drug therapy
  • [MeSH-minor] Combined Modality Therapy. Disease-Free Survival. Female. Humans. Neoplasm Recurrence, Local. Neoplasm Staging. Treatment Outcome

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  • (PMID = 16050566.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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29. Sayedur Rahman M, Al-Sibai MH, Rahman J, Al-Suleiman SA, El-Yahia AR, Al-Mulhim AA, Al-Jama F: Ovarian carcinoma associated with pregnancy. A review of 9 cases. Acta Obstet Gynecol Scand; 2002 Mar;81(3):260-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian carcinoma associated with pregnancy. A review of 9 cases.
  • BACKGROUND: The purpose of this study was to review patients with ovarian cancer in pregnancy, the effectiveness of the available methods of treatment and their prognosis.
  • METHODS: A retrospective review of all women diagnosed to have cancer of the ovary associated with pregnancy who delivered at the authors' hospitals between January 1976 and December 2000.
  • The demography, clinical presentation, time and mode of diagnosis, treatment, pregnancy outcome and maternal survival were noted.
  • RESULTS: The incidence of ovarian carcinoma in pregnancy in the series was 0.08/1000 deliveries.
  • One patient each had dysgerminoma and granulosa cell tumor.
  • Three patients had total abdominal hysterectomy, bilateral salpingo-oophorectomy and omentectomy followed by chemotherapy.
  • Debulking of the tumor was done in a patient in stage III with subsequent chemotherapy.
  • This patient died 13 months from the time of diagnosis of the tumor.
  • CONCLUSIONS: Association of ovarian cancer with pregnancy is a rare occurrence.
  • Early diagnosis and appropriate treatment offers the best prognosis for the patient.
  • The higher survival rates in the series was attributed to a larger number of patients in stage I of the disease and 2 patients with a germ cell tumor and dysgerminoma which have the best prognosis.
  • Aggressive postoperative chemotherapy also contributed to the better outcome.
  • [MeSH-major] Carcinoma / complications. Carcinoma / therapy. Ovarian Neoplasms / complications. Ovarian Neoplasms / therapy. Pregnancy Complications, Neoplastic / mortality. Pregnancy Complications, Neoplastic / therapy

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  • (PMID = 11966485.001).
  • [ISSN] 0001-6349
  • [Journal-full-title] Acta obstetricia et gynecologica Scandinavica
  • [ISO-abbreviation] Acta Obstet Gynecol Scand
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 15
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30. Oltmann SC, Fischer A, Barber R, Huang R, Hicks B, Garcia N: Pediatric ovarian malignancy presenting as ovarian torsion: incidence and relevance. J Pediatr Surg; 2010 Jan;45(1):135-9
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  • [Title] Pediatric ovarian malignancy presenting as ovarian torsion: incidence and relevance.
  • PURPOSE: With ovarian torsion, concern for underlying malignancy in the enlarged ovary has previously driven surgeons to resection.
  • Detorsion alone has been recommended to allow for resolution of edema of the ovary with follow-up ultrasound surveillance to evaluate for a persistent mass, yet is not routine practice.
  • However, the incidence of malignancies presenting as ovarian torsion is not documented.
  • METHOD: After institutional review board exemption (IRB#-022008-095), a 15(1/2)-year retrospective review was conducted to identify cases of operative ovarian torsion in our medical center.
  • RESULTS: A total of 114 patients (mean +/- SEM age, 10 years, 2 days to 19 years +/- 0.53) with operatively proven ovarian torsion were identified.
  • Malignancies consisted of serous borderline tumors (2), juvenile granulosa cell tumor (1), and dysgerminoma (1).
  • All were stage I: the former were stage IA and cured with resection alone, and 1 was a stage IB dysgerminoma, which required chemotherapy.
  • The literature yielded a total of 593 cases of operative ovarian torsion with 9 (1.5%) malignancies and 193 (33%) benign neoplasms.
  • The malignancies were juvenile granulosa cell tumor (n = 4), dysgerminoma (n = 2), serous borderline tumors (n = 2), and 1 undifferentiated adenocarcinoma.
  • CONCLUSION: By combining our series with 13 in the literature, a 1.8% malignancy rate occurred in 707 patients with ovarian torsion, markedly less than the reported malignancy rate of 10% in children with ovarian masses.
  • These data further support the implementation of operative detorsion and close postoperative ovarian surveillance, with reoperation for persistent masses.
  • [MeSH-major] Ovarian Diseases / diagnosis. Ovarian Neoplasms / diagnosis. Torsion Abnormality / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adolescent. Adult. Age Factors. Child. Child, Preschool. Diagnosis, Differential. Dysgerminoma / diagnosis. Dysgerminoma / surgery. Female. Granulosa Cell Tumor / diagnosis. Granulosa Cell Tumor / surgery. Humans. Incidence. Infant

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20105593.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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31. Erdemoglu E, Ozen S: Ovarian gonodoblastoma with yolk sac tumor in a young 46, XX female: case report. Eur J Gynaecol Oncol; 2007;28(6):516-8
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  • [Title] Ovarian gonodoblastoma with yolk sac tumor in a young 46, XX female: case report.
  • BACKGROUND: Gonodoblastomas with ovarian germ cell tumors (OGCTs) other than dysgerminoma are very unusual.
  • This is the first case report of a pure endodermal sinus tumor of the ovary with gonodoblastoma in a 46 XX, female.
  • Fertility sparing surgery was undertaken and revealed a Stage IA endodermal sinus tumor and gonodoblastoma in the same ovary.
  • The patient refused chemotherapy and was followed-up for six months without disease.
  • Tumor markers and immunohistochemical examination may help in the diagnosis of these OGCTs with gonodoblastoma.
  • [MeSH-major] Endodermal Sinus Tumor / genetics. Gonadoblastoma / genetics. Ovarian Neoplasms / genetics

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  • (PMID = 18179152.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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32. Patterson DM, Murugaesu N, Holden L, Seckl MJ, Rustin GJ: A review of the close surveillance policy for stage I female germ cell tumors of the ovary and other sites. Int J Gynecol Cancer; 2008 Jan-Feb;18(1):43-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A review of the close surveillance policy for stage I female germ cell tumors of the ovary and other sites.
  • Ovarian germ cell tumors are rare but very curable at all stages of disease.
  • There is good evidence that surveillance for stage I dysgerminomas is a safe option although many centers worldwide still advocate adjuvant chemotherapy for stage IA nondysgerminomatous tumors, despite the significant risk of developing long-term treatment side effects.
  • Here, we review the safety of our ongoing surveillance program of all stage IA female germ cell tumors.
  • Relapse rates for stage IA nondysgerminomatous tumors and dysgerminomas were 8 of 22 (36%) and 2 of 9 (22%), respectively, plus one patient with mature teratoma and glial implants also relapsed; 10 of these 11 patients (91%) were successfully cured with platinum-based chemotherapy.
  • The overall disease-specific survival of malignant ovarian germ cell tumors was 94%.
  • We have confirmed again that surveillance of all stage IA ovarian germ cell tumors is very safe and that the outcome is comparable with testicular tumors.
  • We question the need for potentially toxic adjuvant chemotherapy in nondysgerminoma patients who have greater than 90% chance of being salvaged with chemotherapy if they relapse later.
  • [MeSH-major] Dysgerminoma / diagnosis. Neoplasm Recurrence, Local / diagnosis. Ovarian Neoplasms / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / metabolism. Female. Humans. Middle Aged. Neoplasm Staging. Population Surveillance. Prognosis. Risk Management. Treatment Outcome

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  • (PMID = 17466047.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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33. Rzepka-Górska I, Błogowska A, Zajaczek S, Zielińska D: [Germinal cell tumors in young and adolescent girls]. Ginekol Pol; 2003 Sep;74(9):840-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Germinal cell tumors in young and adolescent girls].
  • OBJECTIVE: Germ cell tumours are the most common ovarian tumours in childhood and adolescence.
  • This diverse group of tumours derives from germ cells.
  • DESIGN: The aim of this work is presentation of germ cell tumours in the material from our clinic with characteristic clinical features, the scope of operation and effects of many years of observation.
  • MATERIALS AND METHODS: We treated 109 girls with germ cell tumours of the ovary: 13 had malignant tumours: there were 7 patients with dysgerminomas, 2 with endodermal sinus tumour of the ovary, 3 with immature teratomas, 1 with carcinoma embryonale.
  • There can be problems with diagnosis of the syndrome, because developmental features imitate the onset of normal puberty.
  • Most patients with dysgerminoma have stage I of disease and surgery is sufficient.
  • It must be suggested that patients of stage I who wish to preserve childbearing function may be treated with unilateral salpingoophorectomy and adjuvant chemotherapy.
  • Monitoring of the treatment is connected with measurement of biochemical markers.
  • Some of these markers are useful for monitoring of response to therapy.
  • Cytological smears and biopsy specimens from the remaining ovary, peritoneum and subdiaphragmatic area should be obtained laparoscopically.
  • CONCLUSIONS: The sift ultrasonographic investigations can be helpful in the early diagnosis of germ cell tumours of the ovary in girls.
  • Fertility sparing operative treatment is preferred when karyotype is normal.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / therapy. Ovarian Neoplasms / pathology. Ovarian Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / blood. Child. Combined Modality Therapy. Dysgerminoma / pathology. Dysgerminoma / therapy. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / therapy. Female. Germinoma / pathology. Germinoma / therapy. Gonadoblastoma / pathology. Gonadoblastoma / therapy. Gonadotropins / blood. Gonadotropins / genetics. Humans. Poland. Risk Factors. Teratoma / pathology. Teratoma / therapy

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  • (PMID = 14674134.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gonadotropins
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34. Tatekawa Y, Kemmotsu H, Mouri T, Joe K, Ohkawa H: A case of pediatric ovarian dysgerminoma associated with high serum levels and positive immunohistochemical staining of neuron-specific enolase. J Pediatr Surg; 2004 Sep;39(9):1437-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of pediatric ovarian dysgerminoma associated with high serum levels and positive immunohistochemical staining of neuron-specific enolase.
  • At operation, the main tumor arose from the left ovary and was associated with torsion, whereas the other lesions were lymph node metastases.
  • Histopathologic examination indicated that the tumor was a dysgerminoma.
  • The elevated serum levels of tumor markers improved dramatically after the operation and chemotherapy.
  • [MeSH-major] Doxorubicin / analogs & derivatives. Dysgerminoma / enzymology. Neoplasm Proteins / analysis. Ovarian Neoplasms / enzymology. Phosphopyruvate Hydratase / analysis
  • [MeSH-minor] Alkaline Phosphatase / analysis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers. Bleomycin / administration & dosage. CA-125 Antigen / blood. CA-19-9 Antigen / blood. Carboplatin / administration & dosage. Child, Preschool. Chorionic Gonadotropin, beta Subunit, Human / blood. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Female. Humans. Isoenzymes / analysis. L-Lactate Dehydrogenase / blood. Ovariectomy. Torsion Abnormality / etiology. Vinblastine / administration & dosage. alpha-Fetoproteins / analysis

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  • (PMID = 15359410.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / Isoenzymes; 0 / Neoplasm Proteins; 0 / alpha-Fetoproteins; 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; D58G680W0G / pirarubicin; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 3.1.3.1 / Alkaline Phosphatase; EC 4.2.1.11 / Phosphopyruvate Hydratase
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35. Ratnapala SR, Ratnapala SD: Pregnancy after excision of a yolk sac tumour of the ovary followed by chemotherapy. Ceylon Med J; 2004 Dec;49(4):134-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pregnancy after excision of a yolk sac tumour of the ovary followed by chemotherapy.
  • [MeSH-major] Dysgerminoma / diagnosis. Dysgerminoma / therapy. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / therapy. Pregnancy. Pregnancy Outcome. Pregnancy, High-Risk. Yolk Sac / pathology
  • [MeSH-minor] Adult. Cesarean Section. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Ovariectomy / methods. Risk Assessment






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