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3. da Silveira RB, Pigozzo RB, Chaim OM, Appel MH, Silva DT, Dreyfuss JL, Toma L, Dietrich CP, Nader HB, Veiga SS, Gremski W: Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from brown spider (Loxosceles intermedia) venom: from cloning to functional characterization. Biochimie; 2007 Mar;89(3):289-300
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  • [Title] Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from brown spider (Loxosceles intermedia) venom: from cloning to functional characterization.
  • The venom contains several toxins, of which the best biochemically and biologically studied is the dermonecrotic toxin, a phospholipase-D.
  • Purified toxin induces cutaneous and systemic loxoscelism, especially necrotic lesions, hematological disturbances and renal failure.
  • Herein, we describe cloning, heterologous expression and purification of two novel dermonecrotic toxins: LiRecDT4 and LiRecDT5.
  • Circular dichroism analysis evidenced correctly folding for toxins but differences in secondary structures.
  • Both proteins were recognized by whole venom serum antibodies and by a specific antibody to dermonecrotic toxin.
  • Also, recombinant toxins with phospholipase activity induced experimental skin lesions and caused a massive inflammatory response in rabbit skin dermis.
  • Nevertheless, toxins displayed different effects upon platelet aggregation, increase in vascular permeability and not caused death in mice.
  • These characteristics in combination with functional studies illustrates that a family of dermonecrotic toxins exists, and includes two novel members that are useful for future structural and functional studies.
  • They will also be useful in biotechnological ends, for example, as inflammatory and platelet aggregating studies, as antigens for serum therapy source and for lipids biochemical research.
  • [MeSH-major] Spider Venoms / genetics. Spider Venoms / metabolism. Spiders / genetics. Toxins, Biological / genetics
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Capillary Permeability / drug effects. Circular Dichroism. Cloning, Molecular. DNA, Complementary / chemistry. DNA, Complementary / genetics. Electrophoresis, Polyacrylamide Gel. Mice. Molecular Sequence Data. Phospholipases / genetics. Phospholipases / metabolism. Phylogeny. Platelet Aggregation / drug effects. Rabbits. Recombinant Proteins / chemistry. Recombinant Proteins / metabolism. Recombinant Proteins / toxicity. Sequence Analysis, DNA. Sequence Homology, Amino Acid. Skin / drug effects. Skin / pathology

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  • (PMID = 17296256.001).
  • [ISSN] 0300-9084
  • [Journal-full-title] Biochimie
  • [ISO-abbreviation] Biochimie
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ DQ431848/ DQ431849
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Recombinant Proteins; 0 / Spider Venoms; 0 / Toxins, Biological; EC 3.1.- / Phospholipases
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4. Mirzaee S, Eriksson S, Albertioni F: Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: implication for the toxicity of nucleoside analogs in animal models. Toxicology; 2010 Jan 12;267(1-3):159-64
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  • [Title] Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: implication for the toxicity of nucleoside analogs in animal models.
  • Cytosolic and mitochondrial deoxynucleoside kinases (dNKs), as well as 5'deoxynucleotidases (5'-dNTs), control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy.
  • The balance in the activities of these two groups of enzymes to a large extent determines both the efficacy and side effects of these drugs.
  • Because of the broad and overlapping substrate specificities of the nucleoside kinases and 5'-NTs, their tissue distribution and roles in the metabolism of both natural nucleosides and their analogs are still not fully elucidated.
  • Here, the activity of dNKs: dCK and TK (TK1 and TK2) as well as 5'-dNTs: CN1, CN2 and dNT (dNT1 and dNT2) were determined in 14 different adult mouse and rat tissues.
  • In most cases tissue activities of TK1, TK2 and dCK were 2-3-fold higher in the mouse, a similar pattern was found with CN1 and dNTs although with several exceptions, e.g., TK2 activities in muscle extracts from rats were 2-10-fold higher than in the mouse.
  • CN2 had higher levels in the testis, spleen, pancreas and diaphragm and lower level in the lung of mouse compared to rat tissues.
  • The result suggests that a major difference in these activity profiles between mouse and rat may account for discrepancies in pharmacological response of the two animals to certain nucleoside compounds, and may help to improve the usefulness of animal models in future efforts of drug discovery.
  • [MeSH-minor] Adipose Tissue / enzymology. Animals. Kidney / enzymology. Liver / enzymology. Male. Mice. Models, Animal. Rats. Rats, Sprague-Dawley. Thymidine Kinase / metabolism

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  • [Copyright] 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19913594.001).
  • [ISSN] 1879-3185
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Nucleosides; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.- / deoxyribonucleoside kinases; EC 2.7.1.21 / Thymidine Kinase; EC 3.1.3.5 / 5'-Nucleotidase
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5. Ray DE, Fry JR: A reassessment of the neurotoxicity of pyrethroid insecticides. Pharmacol Ther; 2006 Jul;111(1):174-93
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  • [Title] A reassessment of the neurotoxicity of pyrethroid insecticides.
  • Their acute toxicity is dominated by pharmacological actions upon the central nervous system (CNS), predominantly mediated by prolongation of the kinetics of voltage-gated sodium channels, although other mechanisms operate.
  • This review summarizes our present understanding of such actions and the pharmacological options to antagonize them.
  • The review also provides an overview of recent studies that suggest additional effects of pyrethroids: developmental neurotoxicity, the production of neuronal death, and action mediated via pyrethroid metabolites.
  • [MeSH-minor] Animals. Animals, Newborn. Biotransformation. Cell Death / drug effects. Central Nervous System / drug effects. Humans. Ion Channels / drug effects. Ion Channels / metabolism. Neurons / drug effects. Neurotoxicity Syndromes / drug therapy

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  • (PMID = 16324748.001).
  • [ISSN] 0163-7258
  • [Journal-full-title] Pharmacology & therapeutics
  • [ISO-abbreviation] Pharmacol. Ther.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0100165
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Insecticides; 0 / Ion Channels; 0 / Pyrethrins
  • [Number-of-references] 197
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6. Rubio E, Moreno JM, Turrión VS, Jimenez M, Lucena JL, Cuervas-Mons V: De novo malignancies and liver transplantation. Transplant Proc; 2003 Aug;35(5):1896-7
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  • INTRODUCTION: De novo tumors (DNTs) are the leading cause of late death among liver transplant recipients with an incidence of 5% to 15%, which is significantly greater than the general population.
  • PATIENTS: Among 410 patients who received liver allografts between March 1986 and December 2000, 32 (7.8%) developed a DNT.
  • Treatment consisted of surgery in 76.7%, radiotherapy in 16.7%, chemotherapy in 13.3%, and reduction of immunosuppression in 10%.
  • RESULTS: The mean survival time in transplant patients of 122.97 months (95% CI; range 98-147 months) was significantly shorter than controls, 156.5 months (95% CI; range 141-171 months).
  • CONCLUSIONS: DNTs, a complication of long-term immunosuppression in patients after liver transplantation, most frequently presented as skin tumors and PTLD.
  • Occurrence of a DNT was an adverse prognostic factor for survival.
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Cause of Death. Follow-Up Studies. Humans. Middle Aged. Postoperative Complications / mortality. Retrospective Studies. Survival Analysis. Time Factors. Transplantation, Homologous

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  • (PMID = 12962838.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Song JH, Kong DS, Seol HJ, Shin HJ: Transventricular Biopsy of Brain Tumor without Hydrocephalus Using Neuroendoscopy with Navigation. J Korean Neurosurg Soc; 2010 Jun;47(6):415-9
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  • [Title] Transventricular Biopsy of Brain Tumor without Hydrocephalus Using Neuroendoscopy with Navigation.
  • OBJECTIVE: It is usually difficult to perform the neuroendoscopic procedure in patients without hydrocephalus due to difficulties with ventricular cannulation.
  • The procedure was indicated for verification of the histological diagnosis of the neoplasm, which was planned to be treated by chemotherapy and/or radiotherapy as the first line treatment, or establishment of the pathological diagnosis for further choice of the most appropriate treatment strategy.
  • The histopathologic diagnosis was established in all of 6 patients : 2 germinomas, 2 astrocytomas, 1 dysembryoplastic neuroepithelial tumor and 1 pineocytoma.
  • The tumor biopsy sites were pineal gland (n = 2), suprasellar area (n = 2), subcallosal area (n = 1) and thalamus (n = 1).
  • There were no operative complications related to the endoscopic procedure.
  • Image-guided neuroendoscopic procedure improved the accuracy of the endoscopic approach and minimized brain trauma.
  • The absence of ventriculomegaly in patients with brain tumor may not be served as a contraindication to endoscopic tumor biopsy.

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  • (PMID = 20617084.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2899026
  • [Keywords] NOTNLM ; Navigation / Neuroendoscopy / Without hydrocephalus
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8. Roux FX, Nataf F: Cerebral oligodendrogliomas in adults and children. Current data and perspectives. Neurochirurgie; 2005 Sep;51(3-4 Pt 2):410-4
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  • Mean survival is 13 years (154 +/- 20 months), with a mortality at 5 and 10 years of 60% +/- 9%, and a risk of recurrence of 54% +/- 9% at 5 years and 46.5% +/- 10.5% at 5 years.
  • The main differential diagnosis of grade A oligo is dysembryoplastic neuroepithelial tumors (DNT).
  • Inversely, thalamic locations, most often grade B, generally present with a motor deficit; complete removal can be achieved in only 15%.
  • The only efficient treatment is chemotherapy, requiring search for chemosensitivity (1p19q deletion, expression of MGMT gene, analysis by MR-spectroscopy and TEP).
  • [MeSH-minor] Adult. Child. Chromosome Deletion. Chromosomes, Human, Pair 1 / genetics. Diagnosis, Differential. Humans. Magnetic Resonance Spectroscopy. Middle Aged. Neoplasm Staging

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  • (PMID = 16292183.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] eng; fre
  • [Publication-type] Journal Article
  • [Publication-country] France
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9. Slotkin TA, Oliver CA, Seidler FJ: Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. Brain Res Dev Brain Res; 2005 Jun 30;157(2):172-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination.
  • The developmental neurotoxicity of chlorpyrifos (CPF) involves mechanisms other than inhibition of cholinesterase.
  • These results indicate that diverse compounds can exert convergent effects on brain development through their shared potential to elicit oxidative stress, and that the net outcome is dependent upon specific developmental stages in which metabolic demand is especially high.
  • Furthermore, given the common use of terbutaline in the therapy of preterm labor, and the nearly ubiquitous exposure of the human population to organophosphorus pesticides, the combined oxidative burden of exposure to both agents may contribute to the worsened neurodevelopmental outcomes noted in animal models of such dual exposures.
  • [MeSH-major] Brain / drug effects. Brain Damage, Chronic / chemically induced. Chlorpyrifos / toxicity. Neurotoxins / toxicity. Oxidative Stress / drug effects. Prenatal Exposure Delayed Effects. Terbutaline / toxicity
  • [MeSH-minor] Adrenergic beta-Agonists / toxicity. Age Factors. Animals. Animals, Newborn. Cell Death / drug effects. Cell Death / physiology. Cell Differentiation / drug effects. Cell Differentiation / physiology. Cholinesterase Inhibitors / toxicity. Critical Period (Psychology). Disease Models, Animal. Dose-Response Relationship, Drug. Drug Synergism. Female. Lipid Peroxidation / drug effects. Lipid Peroxidation / physiology. Nerve Degeneration / chemically induced. Nerve Degeneration / metabolism. Nerve Degeneration / physiopathology. Pregnancy. Rats. Rats, Sprague-Dawley. Thiobarbituric Acid Reactive Substances / metabolism

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  • (PMID = 15963356.001).
  • [ISSN] 0165-3806
  • [Journal-full-title] Brain research. Developmental brain research
  • [ISO-abbreviation] Brain Res. Dev. Brain Res.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES10356; United States / NIEHS NIH HHS / ES / ES10387; United States / NICHD NIH HHS / HD / HD09713
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adrenergic beta-Agonists; 0 / Cholinesterase Inhibitors; 0 / Neurotoxins; 0 / Thiobarbituric Acid Reactive Substances; JCS58I644W / Chlorpyrifos; N8ONU3L3PG / Terbutaline
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10. López JI, Pomposo-Gaztelu I: [Surgical pathology of epilepsy]. Rev Neurol; 2010 May 16;50(10):616-22
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  • INTRODUCTION: The surgical treatment of refractory epilepsy represents a large step forward in the quality of life and survival of many patients, particularly for those whose pathology is located in the temporal lobe.
  • DEVELOPMENT: The causes of refractory epilepsy with a genuinely neurohistological foundation can be either malformative or neoplastic.
  • The former include cortical dysplasias and hippocampal sclerosis, while the latter involve the so-called glioneuronal tumours (dysembryoplastic neuroepithelial tumour, ganglioglioma) and some glial cell-related tumours.
  • Surgery applied to these processes cures epilepsy in a high percentage of cases that are resistant to pharmacological treatment.
  • [MeSH-minor] Brain Neoplasms / complications. Brain Neoplasms / pathology. Brain Neoplasms / surgery. Ganglioglioma / complications. Ganglioglioma / pathology. Ganglioglioma / surgery. Humans. Neuroectodermal Tumors, Primitive / complications. Neuroectodermal Tumors, Primitive / pathology. Neuroectodermal Tumors, Primitive / surgery. Quality of Life. Temporal Lobe / pathology. Temporal Lobe / surgery. Teratoma / complications. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 20473838.001).
  • [ISSN] 1576-6578
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 36
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11. Daumas-Duport C, Varlet P: [Dysembryoplastic neuroepithelial tumors]. Rev Neurol (Paris); 2003 Jul;159(6-7 Pt 1):622-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Dysembryoplastic neuroepithelial tumors].
  • Dysembryoplastic neuroepithelial tumors DNTs are highly polymorphic tumors that arise during embryogenesis.
  • Their differential diagnosis from gliomas is obviously important to spare these young patients with a normal life expectancy the long- term deleterious effect of radiation or chemotherapy.
  • The diagnosis of DNT must be considered when all the following criteria are present: partial seizures with or without secondary generalization, no neurological deficit or a stable congenital deficit, cortical topography on MRI, absence of peri-tumoral edema and of mass effect.
  • In other locations, the diagnosis of DNT has to be suspected in case of discordance between the neurological status of the patient and the topography of the tumor or of unusual radiological features such as contrast enhancement but no mass effect and no edema.
  • Supratentorial cortical DNTs tend now to be detected more systematically by imaging soon after first seizures.
  • DNTs should therefore be operated soon after diagnosis.
  • However, excellent results can also be obtained by epilepsy surgery in patients with long term drug resistant partial seizures.
  • [MeSH-major] Brain Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Neuroepithelial / pathology. Temporal Lobe / pathology

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  • (PMID = 12910070.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 73
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12. Chen L, Xu QZ, Piao YS, Zhang GJ, Yu T, Yang XP, Yang H, Lu DH: [Dysembryoplastic neuroepithelial tumor: a clinicopathologic and immunohistochemical study]. Zhonghua Bing Li Xue Za Zhi; 2007 Aug;36(8):524-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Dysembryoplastic neuroepithelial tumor: a clinicopathologic and immunohistochemical study].
  • OBJECTIVE: To study the clinicopathologic features, immunophenotype and histogenesis of dysembryoplastic neuroepithelial tumor (DNT).
  • METHODS: Fourteen cases of DNT were retrieved from the archival files of the Department.
  • Histologically, the tumor consisted of a heterogeneous admixture of neuronal and glial cells (including 1 simple form case, 8 complex form cases and 5 non-specific form cases).
  • Variable degrees of cortical dysplasia (CD) were found in 10 out of the 11 cases which had sufficient tissue samples for thorough histologic examination.
  • The morphologic appearance of CD included the presence of heterotopic neurons in molecular layer and/or white matter (7 cases), persistent subpial granular cell layer (4 cases), dyslamination (10 cases) and cellular abnormalities.
  • No tumor recurrence was detected.
  • CONCLUSIONS: DNT is frequently associated with CD.
  • The morphologic diagnosis can be confirmed by immunohistochemical study using a panel of antibodies.
  • [MeSH-major] Basic Helix-Loop-Helix Transcription Factors / metabolism. Brain Neoplasms / pathology. Malformations of Cortical Development / pathology. Neoplasms, Neuroepithelial / pathology. Nerve Tissue Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Anticonvulsants / therapeutic use. Child. Child, Preschool. Epilepsy / drug therapy. Epilepsy / etiology. Female. Follow-Up Studies. Humans. Infant. Intermediate Filament Proteins / metabolism. Male. Microtubule-Associated Proteins / metabolism. Nestin. Oligodendroglia / pathology. Retrospective Studies. Young Adult

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  • (PMID = 17980099.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Intermediate Filament Proteins; 0 / MAP2 protein, human; 0 / Microtubule-Associated Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / OLIG2 protein, human
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13. Baisden BL, Brat DJ, Melhem ER, Rosenblum MK, King AP, Burger PC: Dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: a lesion often misdiagnosed as glioma: report of 10 cases. Am J Surg Pathol; 2001 Apr;25(4):494-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: a lesion often misdiagnosed as glioma: report of 10 cases.
  • The authors report a series of 10 low-grade neoplasms arising in the midline anteriorly in the region of the septum pellucidum with many of the histologic features of dysembryoplastic neuroepithelial tumor (DNT).
  • The tumors, in aggregate, had the histologic features of DNT.
  • No patients received adjuvant chemotherapy or radiotherapy.
  • On the basis of both neuroimaging and histopathology, DNT-like lesions should be considered in the differential diagnosis of midline intraventricular tumors in children and young adults.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoplasm Proteins / analysis. Treatment Outcome


14. Rushing EJ, Thompson LD, Mena H: Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy. Ann Diagn Pathol; 2003 Aug;7(4):240-4
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  • [Title] Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy.
  • We describe a case of anaplastic astrocytoma in a 14-year-old boy arising at the site of a dysembryoplastic neuroepithelial tumor (DNT) 3 years after combined radiation and chemotherapy.
  • The subtotally excised superficial right temporoparietal tumor was originally diagnosed as mixed oligoastrocytoma in 1974; the patient was treated with radiation therapy postoperatively.
  • One year later he underwent a craniotomy to remove cyst fluid and no change was reported in the size of the residual tumor.
  • Postoperatively, he received a 6-week course of chemotherapy (lovustine, CCNU).
  • He remained clinically and radiographically stable until 3 years later, when seizure activity returned and imaging studies were consistent with tumor recurrence.
  • Review of the initial biopsy showed cortical fragments containing abundant calcifications and multinodular structures typical of the complex form of DNT, in addition to specific glioneuronal elements.
  • The specimen from the third surgery showed an anaplastic astrocytoma (Ki-67 up to 12%) and morphologic features characteristic of radiation effect.
  • This is the first documented case of malignant transformation of DNT following radiation and adjuvant chemotherapy.
  • The implications of malignant transformation in subtotally excised complex DNTs and the intriguing issue of the contribution of radiation/chemotherapy are discussed.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Neoplasms, Neuroepithelial / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adolescent. Antineoplastic Agents, Alkylating / therapeutic use. Biomarkers, Tumor / metabolism. Combined Modality Therapy. Craniotomy. Fatal Outcome. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Lomustine / therapeutic use. Male

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  • (PMID = 12913847.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 7BRF0Z81KG / Lomustine
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15. Ratel D, Boisseau S, Davidson SM, Ballester B, Mathieu J, Morange M, Adamski D, Berger F, Benabid AL, Wion D: The bacterial nucleoside N(6)-methyldeoxyadenosine induces the differentiation of mammalian tumor cells. Biochem Biophys Res Commun; 2001 Jul 20;285(3):800-5
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  • [Title] The bacterial nucleoside N(6)-methyldeoxyadenosine induces the differentiation of mammalian tumor cells.
  • The possible biological effect of this nucleoside on eukaryotic cells has been studied on different tumor cell lines.
  • The biological effects of N(6)-methyldeoxyadenosine were not restricted to C6.9 glioma cells since differentiation was also observed on pheochromocytoma and teratocarcinoma cell lines and on dysembryoplastic neuroepithelial tumor cells.
  • Furthermore, the finding that a methylated nucleoside found in bacterial DNA induces a biological process might have implications in gene therapy approaches when plasmid DNAs are injected into humans.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cell Differentiation / drug effects. Deoxyadenosines / pharmacology. Glioma / metabolism. Muscle Proteins. Neoplasms, Neuroepithelial / metabolism. PC12 Cells / drug effects. Phosphoric Diester Hydrolases. Teratocarcinoma / metabolism
  • [MeSH-minor] 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase. 2',3'-Cyclic-Nucleotide Phosphodiesterases / biosynthesis. Animals. Antigens, Differentiation / biosynthesis. Blotting, Western. Cell Cycle / drug effects. Microfilament Proteins / metabolism. Rats. Tumor Cells, Cultured

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  • [Copyright] Copyright 2001 Academic Press.
  • (PMID = 11453663.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Antineoplastic Agents; 0 / Deoxyadenosines; 0 / Microfilament Proteins; 0 / Muscle Proteins; 0 / N(6)-methyldeoxyadenosine; 0 / Tagln protein, mouse; EC 3.1.4.- / 2',3'-Cyclic-Nucleotide Phosphodiesterases; EC 3.1.4.- / Phosphoric Diester Hydrolases; EC 3.1.4.37 / 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; EC 3.1.4.37 / CNP protein, human; EC 3.1.4.37 / Cnp protein, mouse; EC 3.1.4.37 / Cnp protein, rat
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16. Banerjee H, Hawkins Z, Yakubu M, Smoot D, Asktorab M, Dutta SK: 2Am-DNT induces cell death and apoptosis in human cells. J Environ Pathol Toxicol Oncol; 2009;28(3):231-4
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  • [Title] 2Am-DNT induces cell death and apoptosis in human cells.
  • During microbial or mammalian cell metabolism, TNT (2,4,6-tinitrotoluene) is reduced to 2Am-DNT (2-amino-4,6-dinitrotoluene), 4Am-DNT, or 2,4-diamino-NT (2,4-diaminonitrotoluelne) depending on the specific organism.
  • The metabolite 2Am-DNT is the most common of the TBT biotransformation pathways in bacterial and fungal species studied to date. in the mammalian liver cells, TNT is metabolized to 2Am-DNT by the P450 enzyme system.
  • Apoptosis is rapidly emerging as a relevant endpoint for detecting low-dose toxin exposure.
  • We report in this study that 2Am-DNT treatment of mammalian cells causes cell death by apoptosis.
  • Apoptotic changes, such as DNA break down, were detected in treated cells by the production of a dark-brown DAB (diaminobenzidine) signal using the Fragel Klenow DNA fragment detection system, by immunohistochemical techniques with fluorescence microscopy, and by using a microplate reader for a single-stranded DNA binding assay.
  • All of these results showed that 2am-DNT is toxic to mammalian cells and induces apoptosis.
  • [MeSH-major] Aniline Compounds / toxicity. Apoptosis / drug effects. Environmental Pollutants / toxicity
  • [MeSH-minor] Breast Neoplasms / drug therapy. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Cell Line, Tumor. Cell Survival / drug effects. DNA Damage. DNA, Single-Stranded / drug effects. DNA, Single-Stranded / metabolism. Female. Humans. In Situ Nick-End Labeling. Microscopy, Fluorescence. Trypan Blue / metabolism

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  • (PMID = 19888910.001).
  • [ISSN] 2162-6537
  • [Journal-full-title] Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • [ISO-abbreviation] J. Environ. Pathol. Toxicol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / DNA, Single-Stranded; 0 / Environmental Pollutants; 189OOM840S / 2-amino-4,6-dinitrotoluene; I2ZWO3LS3M / Trypan Blue
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17. Altinörs N, Calisaneller T, Gülşen S, Ozen O, Ongürü O: Intraventricular dysembryoplastic neuroepithelial tumor: case report. Neurosurgery; 2007 Dec;61(6):E1332-3; discussion E1333
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  • [Title] Intraventricular dysembryoplastic neuroepithelial tumor: case report.
  • OBJECTIVE: The most common localization of dysembryoplastic neuroepithelial tumors (DNTs) is the supratentorial cortex, often in the temporal lobe.
  • However, intraventricular localization of a DNT is extremely rare.
  • CLINICAL PRESENTATION: A 30-year-old woman presented with a 1-year history of epileptic seizures.
  • Based on histopathological and immunohistochemical evaluation, a DNT was diagnosed.
  • The most recent neuroimaging examinations revealed neither residual nor recurrent tumor.
  • CONCLUSION: Because DNTs are surgically curable and neither radiotherapy nor chemotherapy is required after surgery, recognition of an intraventricular DNT in this location is extremely important.
  • [MeSH-major] Cerebral Ventricle Neoplasms. Lateral Ventricles / pathology. Neoplasms, Neuroepithelial

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  • (PMID = 18162864.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Synaptophysin
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18. Brami-Zylberberg F, Beuvon F, Meder JF: [Case no 1. Neuroepithelial dysembryoplastic tumor]. J Radiol; 2003 Jan;84(1):78-9
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  • [Title] [Case no 1. Neuroepithelial dysembryoplastic tumor].
  • [Transliterated title] Cas no 1. Tumeur neuro-épithéliale dysembryoplasique.
  • [MeSH-major] Brain Neoplasms / diagnosis. Frontal Lobe. Neoplasms, Neuroepithelial / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Adolescent. Biopsy. Diagnosis, Differential. Epilepsy / drug therapy. Epilepsy / etiology. Female. Humans. Magnetic Resonance Imaging. Stereotaxic Techniques

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  • (PMID = 12645516.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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19. Slonim AE, Grovit M, Bulone L: Effect of exclusion diet with nutraceutical therapy in juvenile Crohn's disease. J Am Coll Nutr; 2009 Jun;28(3):277-85
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  • [Title] Effect of exclusion diet with nutraceutical therapy in juvenile Crohn's disease.
  • Anti-inflammatory, immunomodulatory, and monoclonal antibody drugs, as well as growth hormone (GH), frequently fail to achieve sustained remission or reverse growth failure.
  • OBJECTIVE: To test whether an exclusion diet with nutraceutical therapy (DNT) could induce sustained clinical remission and weight gain, and if so does this enhance the ability for GH to reverse growth failure.
  • All were treated with DNT.
  • RESULTS: Within 2 months of starting DNT all six patients went into remission, with discontinuation of all pharmacological drugs.
  • One patient with very severe CD had recurrence of CD symptoms after being in complete remission for 18 months, one patient was in remission for 3 years but symptoms recurred when she became less compliant to DNT and one recently treated patient remains in remission after 6 months.
  • With the addition of rhGH, the 4 growing patients had good-excellent growth response CONCLUSION: DNT engendered prolonged remission and restoration of normal weight in moderate-severe juvenile CD patients, providing conditions that enabled rhGH to stimulate growth.
  • These findings justify larger controlled trials to evaluate the long-term benefit of compliance to DNT in both juvenile and adult CD patients.
  • [MeSH-major] Crohn Disease / diet therapy. Dietary Supplements. Growth Disorders / therapy. Human Growth Hormone / therapeutic use. Micronutrients / therapeutic use
  • [MeSH-minor] Adolescent. Amino Acids / therapeutic use. Animals. Boswellia. Cattle. Colostrum. Combined Modality Therapy. Curcuma. Curcumin / therapeutic use. Female. Fishes. Growth / drug effects. Humans. Lactobacillus. Male. Peptides / therapeutic use. Plant Extracts / therapeutic use. Probiotics / therapeutic use. Prospective Studies. Young Adult


20. Xu F, Prescott MF, Liu PX, Chen ZH, Liau G, Gordon EM, Hall FL: Long term inhibition of neointima formation in balloon-injured rat arteries by intraluminal instillation of a matrix-targeted retroviral vector bearing a cytocidal mutant cyclin G1 construct. Int J Mol Med; 2001 Jul;8(1):19-30
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  • Currently, there is no known therapeutic strategy that has been sufficiently effective to warrant its widespread use.
  • In the present study, the anti-proliferative properties of a matrix (collagen)-targeted retroviral vector bearing a mutant cyclin G1 (DNT 41-249) construct was evaluated in vitro and in vivo.
  • [MeSH-minor] 3T3 Cells. Amino Acid Sequence. Angioplasty, Balloon / adverse effects. Animals. Carotid Arteries / chemistry. Carotid Arteries / pathology. Cell Division / drug effects. Cell Division / genetics. Cell Line. Cyclin G. Cyclin G1. DNA, Antisense / genetics. DNA, Recombinant / genetics. Gene Transfer Techniques. Genetic Therapy / methods. Genetic Vectors / administration & dosage. Humans. Immunohistochemistry. Mice. Molecular Sequence Data. Muscle, Smooth, Vascular / cytology. Muscle, Smooth, Vascular / drug effects. Muscle, Smooth, Vascular / metabolism. Mutation. Rats. Retroviridae / genetics. Sequence Homology, Amino Acid. Time Factors. Treatment Outcome

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  • (PMID = 11408944.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CCNG1 protein, human; 0 / Ccng1 protein, mouse; 0 / Ccng1 protein, rat; 0 / Cyclin G; 0 / Cyclin G1; 0 / Cyclins; 0 / DNA, Antisense; 0 / DNA, Recombinant
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21. Brüning T, Thier R, Mann H, Melzer H, Bröde P, Dallner G, Bolt HM: Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene. J Occup Environ Med; 2001 Jul;43(7):610-5
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  • A cohort of 161 underground miners who had been highly exposed to dinitrotoluene (DNT) in the copper-mining industry of the former German Democratic Republic was reinvestigated for signs of subclinical renal damage.
  • The study included a screening of urinary proteins excreted by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and quantitations of the specific urinary proteins alpha 1-microglobulin and glutathione-S-transferase alpha (GST alpha) as biomarkers for damage of the proximal tubule and glutathione-S-transferase pi (GST pi) for damage of the distal tubule.
  • The exposures were categorized semiquantitatively (low, medium, high, and very high), according to the type and duration of professional contact with DNT.
  • A straight dose-dependence of pathological protein excretion patterns with the semiquantitative ranking of DNT exposure was seen.
  • The damage from DNT was directed toward the tubular system.
  • Data on the biomarkers alpha 1-microglobulin, GST alpha, and GST pi consistently demonstrated a dose-dependent increase in tubular damage, which confirmed the results of screening by SDS-PAGE and clearly indicated a nephrotoxic effect of DNT under the given conditions of exposure.
  • Within the cluster of cancer patients observed among the DNT-exposed workers, only in exceptional cases were normal biomarker excretions found.

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  • (PMID = 11464391.001).
  • [ISSN] 1076-2752
  • [Journal-full-title] Journal of occupational and environmental medicine
  • [ISO-abbreviation] J. Occup. Environ. Med.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Dinitrobenzenes; 0 / Isoenzymes; 0 / Membrane Glycoproteins; 0 / SPINT2 protein, human; 9088-41-9 / Trypsin Inhibitor, Kunitz Soybean; EC 2.5.1.18 / GSTP1 protein, human; EC 2.5.1.18 / Glutathione S-Transferase pi; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase alpha
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22. O'Brien DF, Farrell M, Delanty N, Traunecker H, Perrin R, Smyth MD, Park TS, Children's Cancer and Leukaemia Group: The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. Br J Neurosurg; 2007 Dec;21(6):539-49
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  • [Title] The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours.
  • Dysembryoplastic neuroepithelial tumours (DNETs) were incorporated into the new World Health Organization classification of brain tumours as part of the group of glioneuronal tumours in 1993.
  • Large series of patients with DNETs and pharmaco-resistant epilepsy have been reported.
  • DNETs are most often located in the temporal lobe, occurring in both mesial and lateral temporal locations.
  • DNETs have also been reported in the insular cortex, brain stem, cerebellum, occipital lobe and striatum.
  • Approximately 40% of DNETs are cystic, and solitary nodular, multinodular or diffuse forms have been recognized.
  • Approximately 30% of DNETs are associated with subtle cortical dysplastic changes in the adjacent cortex.
  • DNET nodules usually look like oligodendroglioma, whilst between the nodules it may be possible to recognize vertical columns of neurons surrounded by oligodendrocyte-like cells.
  • Cytologically, oligodendroglial-like cells of DNETs are distinguished from oligodendroglioma by larger nuclei with frequent nuclear indentations and multiple, small nucleoli, whilst oligodendrogliomas consistently show nuclear roundness with one or two occasional nucleoli.
  • DNETs are hypodense on CT and demonstrate decreased signal on the T1-weighted images and a hyper-intense signal on T2-weighted MRI.
  • DNETs associated with pharmaco-resistant epilepsy should be removed early to achieve seizure freedom and prevent tumour progression.
  • It is not advocated to use a stereotactic biopsy only, as this may generate an unrepresentative tissue sample consisting of an oligodendroglial component only and may lead to an incorrect diagnosis.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Neoplasms, Neuroepithelial / diagnosis. Neoplasms, Neuroepithelial / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnostic Imaging / methods. Drug Resistance, Neoplasm / physiology. Epilepsy / diagnosis. Epilepsy / therapy. Female. Humans. Infant. Infant, Newborn. Male. Practice Guidelines as Topic

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  • (PMID = 18071981.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 64
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23. Tsuboi Y, Kurimoto M, Nagai S, Kamiyama H, Endo S: Malignant transformation of oligoastrocytoma: a case report. Brain Tumor Pathol; 2007;24(2):63-8
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  • We report a case of oligoastrocytoma resembling dysembryoplastic neuroepithelial tumor (DNT) with malignant transformation.
  • Magnetic resonance imaging (MRI) revealed an extensive left temporal lobe tumor.
  • She underwent partial resection of the tumor under awake surgery, while preserving her language function.
  • The surgical specimen showed that the majority of the tumor was composed of a glioneuronal element.
  • Therefore, our first pathological diagnosis was oligoastrocytoma and DNT.
  • She then underwent radiation therapy.
  • The tumor recurred at the left temporal lobe in June 2005.
  • The pathological diagnosis was anaplastic oligoastrocytoma with a MIB-1 staining index of 79%.
  • She received PAV (procarvazine, ACNU, and vincristine) chemotherapy, and the tumor subsided transiently.
  • Although the histological findings of the first surgical specimen closely resembled those of DNT, radiologic findings and clinical course were different from those of DNT.
  • The authors concluded that this tumor could be a malignant transformation of oligoastrocytoma mimicking DNT, and we wish to give warning that the presence of a glioneuronal component is not an absolute benign hallmark.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Neuroectodermal Tumors, Primitive / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cell Transformation, Neoplastic. Diagnosis, Differential. Female. Humans. In Situ Hybridization, Fluorescence. Magnetic Resonance Imaging. Neurosurgical Procedures. Radiotherapy

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  • (PMID = 18095133.001).
  • [ISSN] 1433-7398
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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24. Mullins CD, Weis KA, Perfetto EM, Subedi PR, Healey PJ: Triptans for migraine therapy: a comparison based on number needed to treat and doses needed to treat. J Manag Care Pharm; 2005 Jun;11(5):394-402
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  • [Title] Triptans for migraine therapy: a comparison based on number needed to treat and doses needed to treat.
  • OBJECTIVE: Managed care and other decision makers need sound comparative information to support the formulary selection process and reimbursement decisions for the treatment of migraine.
  • The objective of this study was to compare currently marketed triptan therapies using number-needed-to-treat (NNT) and doses-needed-to-treat (DNT) measures.
  • DNT was further used to derive triptan treatment cost to achieve 100 successfully treated patients such that the cost-effectiveness of each treatment regime could be compared from the payer perspective.
  • METHODS: Using published meta-analysis data to categorize patients as treatment success or failure, an NNT and a DNT were derived for each triptan.
  • Treatment success was defined as achieving a 2-hour pain response, sustained through 24 hours postdose.
  • Costs were derived by multiplying DNT by the average wholesale price (AWP) minus 15% for each triptan.
  • The highest total triptan cost of treatment was USD 11,136 for naratriptan 2.5 mg.
  • CONCLUSIONS: Eletriptan 40 mg provides the best value in terms of the lowest DNT, assuming an approximately equal AWP discount for each triptan.
  • Future research should further explore the utility of DNT in managed care decision making.
  • [MeSH-major] Migraine Disorders / drug therapy. Serotonin Receptor Agonists / economics. Serotonin Receptor Agonists / therapeutic use
  • [MeSH-minor] Algorithms. Dose-Response Relationship, Drug. Drug Administration Schedule. Drug Costs. Humans. Managed Care Programs / economics. Managed Care Programs / statistics & numerical data. Piperidines / administration & dosage. Piperidines / economics. Piperidines / therapeutic use. Pyrrolidines / administration & dosage. Pyrrolidines / economics. Pyrrolidines / therapeutic use. Recurrence. Time Factors. Treatment Outcome. Triazoles / administration & dosage. Triazoles / economics. Triazoles / therapeutic use. Tryptamines / administration & dosage. Tryptamines / economics. Tryptamines / therapeutic use

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  • [CommentIn] J Manag Care Pharm. 2005 Jun;11(5):419-21 [15934803.001]
  • (PMID = 15934798.001).
  • [ISSN] 1083-4087
  • [Journal-full-title] Journal of managed care pharmacy : JMCP
  • [ISO-abbreviation] J Manag Care Pharm
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Piperidines; 0 / Pyrrolidines; 0 / Serotonin Receptor Agonists; 0 / Triazoles; 0 / Tryptamines; 121679-13-8 / naratriptan; 22QOO9B8KI / eletriptan; 51086HBW8G / rizatriptan
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25. Spalice A, Ruggieri M, Grosso S, Verrotti A, Polizzi A, Magro G, Caltabiano R, Pavone P, Del Balzo F, Platania N, Iannetti P: Dysembryoplastic neuroepithelial tumors: a prospective clinicopathologic and outcome study of 13 children. Pediatr Neurol; 2010 Dec;43(6):395-402
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  • [Title] Dysembryoplastic neuroepithelial tumors: a prospective clinicopathologic and outcome study of 13 children.
  • Dysembryoplastic neuroepithelial tumors (DNETs) are benign intracortical masses that are typically observed in children and young adults and are classified as glioneuronal tumors (WHO grade I).
  • Large and retrospective series of patients with DNETs have been reported, but prospective studies on pediatric cohorts of patients with DNETs have been lacking.
  • The DNETs were located in the frontal (n = 2), temporal (n = 9), or occipital (n = 2) cortex.
  • In 11/13 cases, the seizures were resistant to drug therapy, and all the children had surgery consisting of extended lesionectomy coupled with neuronavigation.
  • This first prospective study with follow-up monitoring of a childhood population with DNETs confirms, on a long-term basis, that the coupled strategy of extended lesionectomy and neuronavigation has good outcome for long-term seizure control.
  • [MeSH-major] Brain Neoplasms / pathology. Cerebral Cortex / pathology. Neoplasms, Neuroepithelial / pathology. Seizures / pathology
  • [MeSH-minor] Adolescent. Child. Electroencephalography. Female. Humans. Male. Prospective Studies. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21093729.001).
  • [ISSN] 1873-5150
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Markowska-Woyciechowska A, Zub L, Jarus-Dziedzic K, Rabczyński J, Paradowski B, Budrewicz S, Jabłoński P: [Dysembryoplastic neuroepithelial tumor (DNT)--case report and literature review]. Neurol Neurochir Pol; 2000 Sep-Oct;34(5):1031-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Dysembryoplastic neuroepithelial tumor (DNT)--case report and literature review].
  • [Transliterated title] Dysembrioplastyczny nowotwór neuroepitelialny (DNT)--opis przypadku i przeglad piśmiennictwa.
  • Neuroepithelial dysembryoplastic tumour was first described by Daumas-Duport in 1988 and in WHO classification was included into the group of neuronal and mixed neuroglial tumours.
  • This is a benign and very rare tumor with a good prognosis occurring in children and young adults.
  • The tumour caused characteristic clinical symptoms: epileptic fits, supratentorial, intracortical localisation, most often in temporal lobe and specific nodular architecture with heterogenic cell composition.
  • CT examination revealed a tumour in the left parietal lobe.
  • Histological findings showed a typical texture of DNT.
  • The tumour has no tendency for recurrence even in case of incomplete removal and does not require chemotherapy nor radiotherapy which is significantly important for accurate diagnosis, in order to avoid an aggressive therapy in young patients.
  • [MeSH-minor] Adult. Epilepsy / etiology. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 11253470.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 20
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28. Engelhard HH, Stelea A, Cochran EJ: Oligodendroglioma: pathology and molecular biology. Surg Neurol; 2002 Aug;58(2):111-7; discussion 117
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  • RESULTS: On histologic examination, oligodendrogliomas must be differentiated from tumors including the fibrillary astrocytoma, clear cell ependymoma, central neurocytoma, and dysembryoplastic neuroepithelial tumor (DNT).
  • There is no specific immunocytochemical marker allowing for the recognition of human oligodendroglial tumor cells.
  • New molecular and genetic markers may aid in grading oligodendrogliomas and identifying patients with a better prognosis or response to chemotherapy.
  • The combination of allelic losses on chromosomes 1p and 19q has been statistically associated with a longer recurrence-free survival after chemotherapy.
  • CONCLUSIONS: A patient with an oligodendroglioma may at times still present a diagnostic challenge for the neuropathologist.
  • Yet making an accurate diagnosis is essential, since the clinical course and optimal therapeutic approach differs from that of other gliomas.
  • [MeSH-major] Biomarkers, Tumor / analysis. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Oligodendroglioma / genetics. Oligodendroglioma / pathology


29. Tatke M, Suri VS, Malhotra V, Sharma A, Sinha S, Kumar S: Dysembryoplastic neuroepithelial tumors: report of 10 cases from a center where epilepsy surgery is not done. Pathol Res Pract; 2001;197(11):769-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dysembryoplastic neuroepithelial tumors: report of 10 cases from a center where epilepsy surgery is not done.
  • Dysembryoplastic neuroepithelial tumor (DNT) is a recently recognized tumor entity with distinctive clinicopathological features and an excellent long-term prognosis.
  • We report 10 cases of DNT out of neurosurgical specimens sent for histopathological examination since 1994.
  • Epilepsy surgery is not done at our center, and all the cases were sent with a clinical diagnosis of glioma.
  • This study therefore reports 4 cases of simple DNT and 6 cases of complex DNT.
  • It is very important to recognize this entity, as surgery cures the patient, and radiotherapy or chemotherapy is not required.
  • [MeSH-major] Brain Neoplasms / pathology. Epilepsies, Partial / pathology. Neoplasms, Neuroepithelial / pathology
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Neoplasm Proteins / analysis. Prospective Studies. Tomography, X-Ray Computed


30. Sarkar C, Sharma MC, Deb P, Singh VP, Chandra PS, Gupta A, Tripathi M, Bhatia M, Gaikwad S, Bal CS, Jain S: Neuropathological spectrum of lesions associated with intractable epilepsies: a 10-year experience with a series of 153 resections. Neurol India; 2006 Jun;54(2):144-50; discussion 150-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuropathological spectrum of lesions associated with intractable epilepsies: a 10-year experience with a series of 153 resections.
  • BACKGROUND: Surgical management of intractable epilepsies is currently an established mode of therapy in various clinical settings.
  • In addition, 20.9% (32 cases) had dual lesions, majority of which included FCD with ganglioglioma (15 cases) or with dysembryoplastic neuroepithelial tumor (12 cases).
  • [MeSH-minor] Adolescent. Adult. Anticonvulsants / therapeutic use. Child. Child, Preschool. Diffuse Cerebral Sclerosis of Schilder / pathology. Diffuse Cerebral Sclerosis of Schilder / surgery. Drug Resistance. Encephalitis / pathology. Female. Humans. Infant. Male. Neurosurgical Procedures. Retrospective Studies. Temporal Lobe / surgery

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  • (PMID = 16804257.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Anticonvulsants
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